How do drugs halt mitosis?
Maligant tumors are sometimes treated with drugs that halt mitosis, and thus stop the production of new cancer cells. two such drugs, vincristine sulfate and vinblastine sulfate, interfere with the formation of spindle fibers. how could this action halt mitosis?Some drugs can also interfere with DNA...
Asked by April Durney 4 months ago.
Maligant tumors are sometimes treated with drugs that halt mitosis, and thus stop the production of new cancer cells. two such drugs, vincristine sulfate and vinblastine sulfate, interfere with the formation of spindle fibers. how could this action halt mitosis? Some drugs can also interfere with DNA synthesis in treated cells. How could this action halt mitosis? Answered by Jamison Kinstle 4 months ago.
Catagories of Chemotherapy Drugs: In general, chemotherapy agents can be divided into three main categories based on their mechanism of action. Stop the synthesis of pre DNA molecule building blocks: These agents work in a number of different ways. DNA building blocks are folic acid, heterocyclic bases, and nucleotides, which are made naturally within cells. All of these agents work to block some step in the formation of nucleotides or deoxyribonucleotides (necessary for making DNA). When these steps are blocked, the nucleotides, which arethe building blocks of DNA and RNA, can not be synthesized. Thus the cells can not replicate because they cannot make DNA without the nucleotides. Examples of drugs in this class include 1) methotrexate (Abitrexate®),2) fluorouracil (Adrucil®), 3) hydroxyurea (Hydrea®), and 4) mercaptopurine (Purinethol®). Directly damage the DNA in the nucleus of the cell: These agents chemically damage DNA and RNA. They disrupt replication of the DNA and either totally halt replication or cause the manufacture of nonsense DNA or RNA (i.e. the new DNA or RNA does not code for anything useful). Examples of drugs in this class include cisplatin (Platinol®) and 7) antibiotics - daunorubicin (Cerubidine®), doxorubicin (Adriamycin®), and etoposide (VePesid®). Effect the synthesis or breakdown of the mitotic spindles: Mitotic spindles serve as molecular railroads with "North and South Poles" in the cell when a cell starts to divide itself into two new cells. These spindles are very important because they help to split the newly copied DNA such that a copy goes to each of the two new cells during cell division. These drugs disrupt the formation of these spindles and therefore interrupt cell division. Examples of drugs in this class of 8) miotic disrupters include: Vinblastine (Velban®), Vincristine (Oncovin®) and Pacitaxel (Taxol®). Answered by Daryl Dornon 4 months ago.
Drugs that interfere with the normal progression of mitosis belong to the most successful chemotherapeutic compounds currently used for anti-cancer treatment. Classically, these drugs are represented by microtubule binding drugs that inhibit the function of the mitotic spindle in order to halt the cell cycle in mitosis and to induce apoptosis in tumor cells. However, these compounds act not only on proliferating tumor cells, but exhibit significant side effects on non-proliferating cells including neurons that are highly dependent on intracellular transport processes mediated by microtubules. Therefore, there is a particular interest in developing novel anti-mitotic drugs that target non-microtubule structures. In fact, recently several novel drugs that target mitotic kinesins or the Aurora and polo-like kinases have been developed and are currently tested in clinical trials. In addition, approaches of cell cycle checkpoint abrogation during mitosis and at the G2/M transition inducing mitosis-associated tumor cell death are promising new strategies for anti-cancer therapy. It is expected that this "next generation" of anti-mitotic drugs will be as successful as the classical anti-microtubule drugs, while avoiding some of the adverse side effect Answered by Joshua Sampaga 4 months ago.
spindle fibers are used to move the chromosome and orgenelles to opposite sides if you cant dupliccate DNA then you cannot spilt a chromosome for the daughter cells Answered by Sharri Yacko 4 months ago.
What are the benefits and limitations of the extractions of drugs from plants?
Am willing to award 15 points for the best answer, Describe and evaluate the benefits and limitations of extractions of drugs from plants and extractions of drugs from plants applications as well as their effect on life and society.How extractions of drugs from plants and it's...
Asked by Tillie Embry 4 months ago.
Am willing to award 15 points for the best answer, Describe and evaluate the benefits and limitations of extractions of drugs from plants and extractions of drugs from plants applications as well as their effect on life and society. How extractions of drugs from plants and it's applications interact with social, economical, political environment and cultural factors. Answered by Ericka Rubenzer 4 months ago.
I will try my best to give you some information on the subject. economical, sociological, political ramifications would require hundreds of pages and months of study and fact finding. Many pharmaceuticals are so complex that it is not economically feasible to synthesise it in a laboratory. e.g. the anti-cancer drugs vincristine sulfate and vinblastine sulfate are so complex that plant extraction is the only economical production method. ( form the mediterranean periwinkel plant). Some chemicals, like antibiotics are used long before their chemical structure is discovered, and they are are extracted from bacterial or fungal fermentation). . A good example is penecillin. The exact molecular structure was determined decades after its first use. And laboratory synthesis was effected 50 years after Alexander Fleming's first discovery. It is still cheaper to extract the basic beta lactam molecule and modify it chemically in order to make newer semi sybthetic derivatives. (like ampicillin, cloxacillin, methicillin etc.). There are problems with natural plant exctracts. The source plant can be rare and in danger of going extinct if heavily exploited. A good example is the anticancer drugs taxol and paclitaxel. The source pacific yew tree is an uncommon plant and in danger. A bacterial alternate source has recently been discovered.. Hope that helps. Doc. Dan. Answered by Daron Babeu 4 months ago.