VIDAZA Ressources

Application Information

This drug has been submitted to the FDA under the reference 050794/001.

Names and composition

"VIDAZA" is the commercial name of a drug composed of AZACITIDINE.

Answered questions

My mother has been diagnosed with leukemia?
My mother is 76, had breast cancer more than 10 years ago, and underwent a mastectomy and chemo at that time for treatment. Now, she has developed leukemia, and her doctor is giving her a few months to live & recommending Vidaza to prolong her life by a bit.My wife and I recently had twins and we were able to... Asked by Nadia Fryling 4 months ago.

My mother is 76, had breast cancer more than 10 years ago, and underwent a mastectomy and chemo at that time for treatment. Now, she has developed leukemia, and her doctor is giving her a few months to live & recommending Vidaza to prolong her life by a bit. My wife and I recently had twins and we were able to successfully save stem cells from the umbilical cord of one of our twins. Is it possible these stem cells can be used to treat her? The answer to my question, and any other thoughts are appreciated. Answered by Toney Ivon 4 months ago.

Stem cell transplants and bone marrow transplants are done for patients with leukemia or lymphoma when treatment has destroyed the bone marrow. If your mother can be put into remission then the transplant can occur. It's useless unless she can be put into remission. A bone marrow transplant or stem cell transplant is used not necessarily as a treatment but it's used to help make sure cancer does not return. In finding a donor blood type is not the only important factor. There are 6 markers they look for in determining how good of a match you are. A 6/6 match is, obviously, the best match but a 5/6 match can also be accepted but there is a slightly greater chance of transplant rejection. The test for a possible match is easy - my children all had their cheek swabbed to test and see how close of a match they were to my 2 year old son E who has AML leukemia. He is on the transplant list right now waiting for a BMT and a matching donor. My 6 year old was the closest match but he was not a close enough match to donate to E. Before the recipient can have the transplant, he or she must go through intense chemotherapy, or sometimes radiation or both, in order to kill all remaining cancerous cells and to make room for the new bone marrow that is about to be transplanted. After the chemotherapy and/or radiation, the bone marrow is introduced directly into the blood. The donated cells are introduced through a port-a-cath or a central line of some kind but my son E has a port (which by the way I think is one of the greatest inventions in the history of medicine - it makes everything so much easier). So there is no actual surgery involved in the transplant on the recipient's side. The new stem cells find their way from the blood into the bones and if everything goes right, the transplant will take hold and the donor's cells will take over and produce healthy cells. Typically, hospitalization lasts for over a month to ensure the transplant was effective and is not being rejected. The patient is kept in isolation with only close family allowed to see them due to the fact that they have no immune system. Full recovery typically takes around a year. I hope this helped you out some and I hope the best for your mother. If you have any more questions feel free to email me ([email protected]) or IM me (crazycanuckj). Answered by Nieves Knetsch 4 months ago.

Its possible. You would have to see if the stem cells are an HLA tissue type match to your mother. The best chance at a match is a full blooded sibling at 1 in 4. After that the best chance is a parent or a child, at 1 in 8. Beyond that direct relationship, its unlikely a person would be a match. Cord blood does give leeway on the match, compared to using marrow donated from an adult. However, being that the cord blood belongs to the grandchild, that is still a lil far down the chain to be a match (but is possible and should be considered if she will be going through the bone marrow transplant.) In all honesty, you are far more likely to be a match to your mother than your child is. However, there are complications. First, your mothers age and over all health other wise. A bone marrow transplant is incredably traumatic. If she has a lot of other health problems, it may not be the best option for her. On top of that, using cord blood adds a couple of complications that dont exist with marrow. Also, one unit of cord blood does not contain enough stem cells to transplant an adult, so if the cord blood was used, they would still have to find a second matching unit, that would need to also be a match with your child. Answered by Demetria Wander 4 months ago.

yes they can--my sister has it n my niece had 2 babys for her-the dumb nurse thru the cord away n was unable to save it after that-my sister paid for the procedure to be done the day after birth. the nurse got fired. (my niece is 18 n we told her no more kids! wait for a donation) good for u to save her or add more life. i hope it works out for u all! havent heard of that drug b4-my sis is getting chemo thru i.v.s but shes 40 Answered by Dionna Limburg 4 months ago.

I certainly would check with her specialist regarding the stem cells. Answered by Timika Warren 4 months ago.


What are the chances of surviving acute leukemia on a 67 year person?
My mother was diagnosed with myeloproliferative syndrome like a pre-leukemia 2 years ago and was being treated with vidaza which kept her stable until recently where her disease turned into acute leukemia, she is 67 years old and she is very weak, the doctor is afraid she might not even be strong enough to survive... Asked by Merri Arocho 4 months ago.

My mother was diagnosed with myeloproliferative syndrome like a pre-leukemia 2 years ago and was being treated with vidaza which kept her stable until recently where her disease turned into acute leukemia, she is 67 years old and she is very weak, the doctor is afraid she might not even be strong enough to survive this new chemo treatment that she will go through. Does anybody know or has gone through to a similar case? Any percentages of chance of survival? Answered by Akilah Jui 4 months ago.

It's always heart breaking when our parents get sick. Survival rates are not good in adults. At 67 and without treatment, the 5yr survival rate is less than 5%. With aggressive chemo/radiation, the 5 year survival rate for all adults is 50%, approximately 35% for people over the age of 65. She'll spend much of the first year of that time sick from the treatment. If the doctors are concerned, she is probably not a good candidate for surviving treatment. Even with aggressive treatment the disease had a high probability of reoccurring again after a few years. By the age of 75, for acute cases hospice care and pain management is generally preferred instead of aggressive adjuvant therapy. 67 to get fatal cancer is really young and a horrible tragedy. Answered by Dung Goold 4 months ago.

My mother developed acute leukemia at the age of 72. She was considered too old for a bone marrow transplant, so her only chance for survival was to have massive chemotherapy to kill all the bone marrow in her system with hopes that her body could regenerate healthy bone marrow afterwards. It would have required a lenthy stay in an isolation unit in the hospital. Even so, the odds were against her survival. In her case, she developed a lung condition (her lungs were damaged from an earlier infection) and didn't live long enough to begin chemotherapy. Acute leukemia is tough for older adults to beat. Answered by Shelli Shelpman 4 months ago.

seek for solutions to get help for my 28 365 days previous son. Has a intense white blood count number and themes with cardiovascular device. He became continuously a wellbeing youngster except kidney themes at the same time as he became born and that were a situation for years. i do not favor to loss him and that i basically love him a lot. He has the great heart interior the international for each person. Any assistance please Answered by Eura Bouvia 4 months ago.


As my husband has aml m0m1 age26 45/of bloats after first chemo 2/ say me the best treatment to overcome .?
Asked by Leslie Woodgate 4 months ago.

I'm guessing you mean 45% blasts after first cycle. The treatment of AML depends on the subtype, morphology, and cytogenetics of AML and the patient’s overall health. In many cases, a team of doctors will work with the patient to determine the best treatment plan. The most successful treatment for AML depends on the results of the first treatment, so it is important for patients to have the initial treatment at a center experienced with AML. Patients are also encouraged to consider clinical trials as a treatment option when making treatment plan decisions. A clinical trial is a research study to test a new treatment to prove it is safe, effective, and possibly better than standard treatment. Your doctor can help you review all treatment options. Researchers are looking at the use of existing drugs given in different doses and schedules, as well as new drugs. Specific research includes the use of drugs called hypomethylating therapy, such as azacitidine (Mylosar, Vidaza), and the new drug laromustine (Cloretazine, Onrigin). Targeted therapy. Targeted therapy is a treatment that targets specific genes, proteins, or the tissue environment that contributes to cancer growth and survival. Researchers are studying ways to block the products of specific mutations found in AML cells. For example, about 30% of patients with AML have mutations in a gene that makes a protein called FLT3, which can increase the growth of AML cells. Drugs that block FLT3 are being tested in clinical trials. Other targeted therapies are being researched that could block the proteins in AML cells that cause resistance to chemotherapy (keeps the chemotherapy from working). Specific targeted therapy drugs being researched include gemtuzumab ozogamicin (Mylotarg), sorafenib (Nexavar), and tipifarnib (Zarnestra). Immunotherapy. Immunotherapy (also called biologic therapy) is designed to boost the body’s natural defenses to fight the cancer. It uses materials either made by the body or in a laboratory to bolster, target, or restore immune system function. Researchers are specifically looking at the use of antibodies directed against the AML cells. In short this is only something that can be discussed in depth with your husbands treating doctor for the best treatment option. Answered by Allie Ripke 4 months ago.


Help me, I got New kind of diease from printer ink desyroyed my bone marrow. ATTN:All worlds blood specialist?
My friend passed away may God bless his soul Asked by Sherril Budz 4 months ago.

have been suffering with Myelodysplastic Syndromes since 2001, it started with tiredness, dizziness and shortness of breath. The lowest blood counts are the hemoglobin and red cells, the hemoglobin range from 6.0 to 9.5, and the red cells range from 2.0 to 2.45. The normal value for Hemoglobin is 14.0-10.0 g/dl, the normal red cells are 4.30-5.90 M/cu mm. Myelodysplastic syndromes affect blood cell production and behavior. Blood carries oxygen, chemicals and hormones to the cells in the body and helps remove toxins and waste. Red blood cells carry oxygen to the tissues (muscles, bones, nerves and organs). Low red blood counts or malfunctioning red blood cells can cause anemia. Symptoms are paleness, feeling tired, fast-beating or pounding heart, dizziness, shortness of breath or headaches. The five categories of MDS are: Refractory anemia Refractory anemia with ringed sideroblasts Refractory anemia with excess blasts Refractory anemia in transformation to acute leukemia Chronic myelomonocytic leukemia The disease categories on the lower end of this list are more serious and have a worse prognosis than those at the top. Refractory anemia and refractory anemia with ringed sideroblasts primarily affect the red blood cells and are the most common forms of MDS. Refractory anemia with excess blasts is present when immature white blood cells are found in the bone marrow in abnormally large numbers (five to 20% bone marrow blasts, compared to normal blasts of less than one percent). Refractory anemia with excess blasts in transformation occurs when blasts become markedly increased (more than 20%) and may indicate that MDS will change to an acute form of leukemia. The category that I come under is Refractory Anemia. MDS is difficult to diagnose because of the absence of symptoms in the early stage of the disease. Often it is accidentally discovered during a routine physical exam or blood test. Routine screening tests do not exist for MDS, but if the disease is suspected, the doctor may order these tests: Complete blood count. A small amount of blood is drawn from the arm, and the lab measures red blood cells, white blood cells and platelets in the sample. Bone marrow biopsy An examination of the chromosomes that carry genetic material I get the complete blood count done every week and receive blood transfusion once every three weeks or earlier sometimes. Medicines such as Procrit, Arenesp, Epogen has no effect on me. Revlimid and other similar drugs do not help either. Presently I am given Chemotherapy (Vidaza) for the past 12 months and there has been no positive results so far. Answered by Caroyln Desorcy 4 months ago.

Actually it was my friend who has this disease and he reported to me that he used to sit in a Lucent Technology printer room and the ink particles in the air got in his blood stream through inhelation. Originally that was the diagnosis from doctors hardly any one survive this disease. In his case 20% of baby blood cells produced by bone marrow were dead and appeared black under microscope. One of the worlds greatest doctor is treating him with Chemotherapy and seems like symptoms has somewhat different now. Now it is some kind of severe anemia however he has extra iron in his blood. He took some experimental drug to cure above disease which seems to cause neuropathy at the bottom of his feet which is very painful. So far that has no cure for that side effect also available. Answered by Willodean Caspersen 4 months ago.

Actually it was my friend who has this disease and he reported to me that he used to sit in a Lucent Technology printer room and the ink particles in the air got in his blood stream through inhelation. Originally that was the diagnosis from doctors hardly any one survive this disease. In his case 20% of baby blood cells produced by bone marrow were dead and appeared black under microscope. One of the worlds greatest doctor is treating him with Chemotherapy and seems like symptoms has somewhat different now. Now it is some kind of severe anemia however he has extra iron in his blood. He took some experimental drug to cure above disease which seems to cause neuropathy at the bottom of his feet which is very painful. So far that has no cure for that side effect also available. Answered by Krystyna Sproule 4 months ago.

You have no choice but to keep having blood transfusions and be monitored for any progression of your disease. I don't know of any links between MDS and printer ink. What makes you think that has caused it? Answered by Charity Stillings 4 months ago.


Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
050794/001 VIDAZA AZACITIDINE POWDER/IV (INFUSION), SUBCUTANEOUS 100MG per VIAL

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
050794/001 VIDAZA AZACITIDINE POWDER/IV (INFUSION), SUBCUTANEOUS 100MG per VIAL
201537/001 AZACITIDINE AZACITIDINE POWDER/IV (INFUSION), SUBCUTANEOUS 100MG per VIAL
204949/001 AZACITIDINE AZACITIDINE POWDER/IV (INFUSION), SUBCUTANEOUS 100MG per VIAL
207234/001 AZACITIDINE AZACITIDINE POWDER/IV (INFUSION), SUBCUTANEOUS 100MG per VIAL
207518/001 AZACITIDINE AZACITIDINE POWDER/IV (INFUSION), SUBCUTANEOUS 100MG per VIAL
208216/001 AZACITIDINE AZACITIDINE POWDER/IV (INFUSION), SUBCUTANEOUS 100MG per VIAL

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