VEREGEN Ressources

Application Information

This drug has been submitted to the FDA under the reference 021902/001.

Names and composition

"VEREGEN" is the commercial name of a drug composed of SINECATECHINS.

Answered questions

Could I have warts?
I have also had anal sex with a I dont know how I could have it. Asked by Tiera Buzick 4 months ago.

Genital warts (or Condyloma, Condylomata acuminata, or venereal warts) is a highly contagious sexually transmitted infection caused by some sub-types of human papillomavirus (HPV). It is spread through direct skin-to-skin contact during oral, genital, or anal sex with an infected partner. Genital warts are the most easily recognized sign of genital HPV infection. They can be caused by strains 6, 11, 30, 42, 43, 44, 45, 51, 52 and 54 of genital HPV; types 6 and 11 are responsible for 90% of genital warts cases.[1] Most people who acquire those strains never develop warts or any other symptoms. HPV also causes many cases of cervical cancer; types 16 and 18 account for 70% of cases. Genital warts often occur in clusters and can be very tiny or can spread into large masses in the genital or penis area. In women they occur on the outside and inside of the vagina, on the opening (cervix) to the womb (uterus), or around the anus. They are approximately as prevalent in men, but the symptoms may be less obvious. When present, they usually are seen on the tip of the penis. They also may be found on the shaft of the penis, on the scrotum, or around the anus. Rarely, genital warts also can develop in the mouth or throat of a person who has had oral sex with an infected person. The viral particles are able to penetrate the skin and mucosal surfaces through microscopic abrasions in the genital area, which occur during sexual activity. Once cells are invaded by HPV, a latency (quiet) period of months to years may occur. HPV virus can last from 3 months to 2 years without a symptom.[citation needed] Having sex with a partner whose HPV infection is latent and demonstrates no outward symptoms still leaves one vulnerable to becoming infected. Contents [hide] 1 Treatment 2 Misdiagnosis cautions 3 References 4 External links [edit] Treatment Genital warts may disappear without treatment, but sometimes eventually develop a fleshy, small raised growth. There is no way to predict whether they will grow or disappear. Depending on the size and location of the wart, and other factors, a doctor will offer one of several ways to treat them. Sinecatechines (Veregen) [also Polyphenon E]: according to the manufacturer's product information, this is a new, high-tech ointment made of several green-tea-extracted catechines. The ointment has an immuno-modulatory effect and also directly acts on infected cells, while messengers (Cytokines, Interferon) are released, and cells of the immune system invade and destroy infected cells of the warts. It is FDA-approved but VERY expensive. Imiquimod (Aldara) a topical immune response cream, applied to the affected area A 20% podophyllin anti-mitotic solution, applied to the affected area and later washed off A 0.5% podofilox solution, applied to the affected area but not to be washed off A 5% 5-fluorouracil (5-FU) cream Trichloroacetic acid (TCA) Pulsed dye laser Liquid nitrogen cryosurgery Electric or laser cauterization Condylox Podophyllin and podofilox should not be used during pregnancy, as they are absorbed by the skin and could cause birth defects in the fetus. 5-fluorouracil cream should not be used while trying to become pregnant or if the person taking the medication could be pregnant. Small warts can be removed by freezing (cryosurgery), burning (electrocautery), or laser treatment. Surgery is occasionally used to remove large warts that have not responded to other treatment. Some doctors inject the antiviral drug interferon-alpha directly into the warts, to treat warts that have returned after removal by traditional means. The drug is expensive, and does not reduce the rate that the warts return[citation needed]. Although treatments can remove the warts, they do not remove the HPV virus, so warts can recur after treatment. Traditional theories postulated that the virus remained in the body for a lifetime. However, new studies using sensitive DNA techniques have shown that through immunological response the virus can either be cleared or suppressed to levels below what PCR tests can measure. [2] According to the Center for Disease Control's report on HPV to Congress in 2004, studies have shown that 70% of new HPV infections clear within one year, and as many as 91% clear within two years. The median duration of new infections is typically eight months. The gradual development of an effective immune response is thought to be the likely mechanism for HPV DNA clearance. The state of the immune system determines the chances of removing the virus entirely and can be affected by factors such as HIV infection, certain medications, stress, or illness.[3] There is even some suggestion that effective treatment of the wart may aid the body's immune response[citation needed]. [edit] Misdiagnosis cautions It is a common misconception among men that hirsuties papillaris genitalis are genital warts. Hirsuties papillaris genitalis is not contagious and no treatment for it is necessary. Some may deem it unsightly and there are various methods of ridding the penis of the condition such as carbon dioxide laser treatment. Genital warts (condylomata) should not be confused with Molluscum contagiosum (MC), which is often transmitted sexually, but does not occur internally as do condylomata. MC looks like small warts, which are much smaller than condylomata genital warts. It does not increase the risk of cervical cancer for women. Genital warts should not be confused with Fordyce's spots, which are considered benign. Answered by Rosalva Colee 4 months ago.

This Site Might Help You. RE: Could I have warts? I have 1 sorta wierd skin bump. It is very small.and near that I have almost invisible bumps that Itch only when being rubbed by something like my underwear or hair. I am scared. could it be jockage? could the skin bump be a skin flap? Answered by Kerri Reisen 4 months ago.

Well....... look at it closely, are there any dark spots? If there are, then you have tiny blood vessels feeding a wart. Warts also bleed when you pick at them. I have never had a wart that iched. It may be just a skin flap. Have it checked if you are worried. Answered by Clarissa Wiley 4 months ago.

What is your opinion on fourchette bumps/patches?
Hello. I went into my OBGYN but my normal doctor wasn't there and instead, I was evaluated by her nurse practitioner. I had my reserves about seeing her, but I really needed to be evaluated for my bumps and also receive a pap smear. I went there because I had noticed a sort of growth on my posterior fourchette... Asked by Sondra Sia 4 months ago.

Hello. I went into my OBGYN but my normal doctor wasn't there and instead, I was evaluated by her nurse practitioner. I had my reserves about seeing her, but I really needed to be evaluated for my bumps and also receive a pap smear. I went there because I had noticed a sort of growth on my posterior fourchette that resembled skin but was rougher in texture. It is raised but not necessarily bumpy if that makes sense. More just like raised skin that might move around if touched. It's a bit tender, but nothing too bad and I can't feel it during my normal day at all. Anyways, I went into the office, and the nurse practitioner examined me but she had to call in another person which kind of concerned me and the nurse's only response was "Looks like genital warts to me." (which is indicative of HPV) That was all she said, and I don't know, it just seemed like they brushed it off rather quickly and didn't really give it a thorough look through or examination. Then they proceeded with the pap smear. As I was leaving, she gave me some Veregen ointment to help remove the "warts" and they gave me some papers on HPV and sent me on my way. Well I just got my results back today, and the pap smear came back as class 1, or normal, and if HPV was detected, wouldn't it come back as at least class 2, or abnormal? I called her up and she was super vague and to be honest, she didn't seem like she knew what she was talking about. Now I'm a neuroscience student, so I'm not completely clueless to medical stuff, so I definitely don't feel comfortable when I get vague answers and I really don't like the paranoid feeling that it might not be what she said it was. Here are some basic facts about the situation/symptoms: 1) I've only had sex with 1 person EVER (in January) and right before we slept together he was tested and all of that for STDs and what not. And this guy is a clean freak and is SUPER careful about that stuff, so I can't imagine it would be him, but then again, I know HPV can be quite elusive, so it's not completely ruled out. 2) The rough bumpy area is located on my posterior fourchette. 3) It is a tad tender, seems swollen since I've started using the cream, but otherwise does not bother me throughout the day. 4) I had been using two different brands of feminine hygiene wipes quite excessively (which I now know NOT to use those anymore because it upsets the pH balance) 5) When I first had sex, it hurt BAD. Like externerally, not internally or anything. And I figured it was normal since it was my first time, but the more we did it, it seemed like it hurt more at the base of my vagina (the fourchette area) and I noticed some bleeding at times. He was a bit rough but I didn't really think anything of it but the main thing was that every single time we had sex, IT BURNED SO BAD WHEN I PEED AFTERWARDS and it was generally sore for about 2 days afterward at the base of my vagina. 6) I noticed it about 3 weeks after we last had sex (which means it could've easily been there longer, that's just when I actually noticed it) 7) I am severely prone to bladder infections and bacterial vaginosis, but I don't know if that's a factor at all. I am generally just on edge on now because I have already been mis-diagnosed once (it was a yeast infection rather than bacterial vaginosis) from this practitioner and she gave me medicine for something that wasn't there, so I just want to be informed of all possibilities. Those are the basic facts surrounding the situation. Here is what I gathered from all my research (which I would love to have your opinion on): 1) Could it be a fourchette fissure or tear of some kind that got irritated or infected either due to basic bacteria buildup or possible inflammation due to the feminine wipes I had been using? 2) If it IS in fact HPV, wouldn't the pap smear show up as abnormal instead of normal? This is what really got me because it came back as perfectly clear and it just seems really off to me. 3) Again with the fissure or tear theory, could it have just been a result of rough sex in which the skin tore and it just got irritated with either wipes or other means? 4) It seems like it is just getting more and more irritated from the use of the Veregen cream and it concerns me because I'm not 100% sure it's actually warts. 5) There's not really a texture to it, more like a rough patchy type of growth. I'm not feeling a cauliflowery texture as is described in most HPV stories. Sorry this is so long, I just wanted to explain what is going on. I am in the process of getting a second opinion (as long as insurance allows), but I would greatly appreciate your opinion on this. Is it seeming more like HPV or something else? Let me know. Thanks in advance for all answers! Answered by Deadra Latif 4 months ago.

HPV testing is not included in any STI test. There is not HPV test for the external genital area of the male or female. HPV of the external genital area can only be diagnosed with a visible lesion. Some lesions of the external genital area do not look like warts most genital warts do not look like the pictures on the internet. Sometimes an HPV infection of the external genital area can be raised or flat the lesion can be white, pink, flesh or dark brown colored looking more like a mole than a wart. Lesions can be one single or they can be in clustered. Sometimes it is difficult to diagnose lesion that are not more common looking. We can acquire an HPV infection from the first person we engage in sex and with only one sexual act. The virus is the most common STI. Most men and women that have engaged in sex with anyone else has been exposed to the virus. Many women and women carry HPV without showing genital warts. A person may not know they are transmitting the virus. Condoms help but do not give 100% of HPV. Most topical can irritate the sensitive genital tissue. Our Pap test looks for abnormal cell changes of the cervix. No, a Pap test alone is not a test for HPV. A Pap test is not used in diagnosing external genital warts A Pap test with co-testing for HPV is not an all over the screening test for HPV. A Pap test does not collect any cells of the external genital area. You can have HPV and your Pap test be negative. Newer guidelines state that HPV testing should not be done in women under 30 because the virus is so common. HPV co-testing with our Pap is recommended at age 30. HPV co-testing only screens for high risk HPV types of the cervix. Our Pap test and the HPV tests are screening for the cervix only looking. A Pap test can be positive for abnormal cell changes but the HPV test is negative meaning that the cells of the cervix are probably due to low risk HPV types. Most all abnormal cell changes are due to the virus. The genital area is sensitive to many things, so yes you could have an allergic reaction to the wipes you are using. You have doubts that the area is due to HPV, I would get a second opinion from a dermatologist. A dermatologist is a skin specialist and are very informed about many issues that can cause irritation of the genital skin tissue. Second opinions are so valuable when we are in doubt. My HPV infection of the external genital area didn’t look anything like a genital wart. A dermatologist is more likely to take a biopsy of the lesion is they are unsure. My GYN brushed it off as nothing. I talked with my dermatologist and she examined it excised it and sent it to the lab, it was confirmed VIN due to HPV carcinoma in situ. Make an appointment as soon as you can. I would probably discontinue the topical before a second opinion. Good luck in finding your answers. Other conditions that can affect the vulva: Lichen sclerosis lichen planus, Lichen simplex chronicus Vulval intraepithelial neoplasia Answered by Karan Vanderloo 4 months ago.

Fissuring Of Posterior Fourchette Answered by Dawne Ovellette 4 months ago.

Most women that present with posterior fourchette fissures are sexually active and symptoms follow intercourse. Symptoms may be mild, moderate or severe in intensity, and usually resolve within a few days. Answered by Manie Schoenhut 4 months ago.


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