Application Information

This drug has been submitted to the FDA under the reference 018768/001.

Names and composition

"VEPESID" is the commercial name of a drug composed of ETOPOSIDE.

Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
018768/001 VEPESID ETOPOSIDE INJECTABLE/INJECTION 20MG per ML **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
019557/001 VEPESID ETOPOSIDE CAPSULE/ORAL 50MG
019557/002 VEPESID ETOPOSIDE CAPSULE/ORAL 100MG

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
018768/001 VEPESID ETOPOSIDE INJECTABLE/INJECTION 20MG per ML **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
019557/001 VEPESID ETOPOSIDE CAPSULE/ORAL 50MG
019557/002 VEPESID ETOPOSIDE CAPSULE/ORAL 100MG
074166/001 TOPOSAR ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074227/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074228/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074284/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074290/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074320/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074351/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074510/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074513/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074529/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074813/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074968/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074983/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
075635/001 ETOPOSIDE ETOPOSIDE CAPSULE/ORAL 50MG

Ask a doctor

A licensed doctor will try to answer your question for free as quickly as possible. Free of charge during the beta period.

Answered questions

What is the Generic name for?
Anadrol Casodex Cialis VePESID Asked by Kiara Twersky 1 year ago.

Anadrol- Oxymetholone Casodex- Bicalutamide Cialis- Tadalafil VePESID- Etoposide Answered by Jani Delacueva 1 year ago.

La disfunción eréctil es la incapacidad del hombre para lograr y mantener una erección suficiente tanto para su propia y por las necesidades de los socios en la gestión de las relaciones sexuales. Si usted sufre de disfunción eréctil debe intentar esta solución natural que ya ha resuelto este problema para muchos hombres de todo el mundo! [Link] Answered by Logan Shorty 1 year ago.

anadrol = oxymetholone casodex = bicalutamide cialis = tadalafil vepesid = etoposide Answered by Sandy Brumsey 1 year ago.

go to wikipedia then you will find out. that is the best way. Answered by Larisa Shenkel 1 year ago.


Where does the name VP16 come from?
The chemotherapy agent etoposide is also known as VP16. What is the history of the name VP16? Asked by Vanessa Scaringe 1 year ago.

Toposar, VePesid, and Etopophos are trade names for Etoposide. VP-16 and Etoposide Phosphate are other names for Etoposide. In some cases, health care professionals may use the trade names Toposar, VePesid, and Etopophos or other names VP-16 and Etoposide Phosphate when referring to the generic drug name Etoposide. Drug type: VP-16 is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. This medication is classified as a "plant alkaloid" and "topoisomerase II inhibitor." Answered by Mallie Duford 1 year ago.


Is Zyrtec safe with grapefruit?
Asked by Joette Lovitt 1 year ago.

yes its safe in case youre interested: (disregard the numbers.. they were my own notes) Medications that should be avoided with grapefruit amiodarone (Cordarone)8 astemizole (Hismanal)5,9 atorvastatin (Lipitor) budesonide (Entocort)8 buspirone (BuSpar) cerivastatin (Baycol)5,9 cilostazol (Pletal)5 cisapride (Propulsid, Prepulsid)9 colchicine 5 eletriptan (Relpax)5 etoposide (Vepesid)8,10 halofantrine (Halfan) indinavir (Crixivan)10 lovastatin (Mevacor) mifepristone (Mifeprex)5 pimozide (Orap)5 sildenafil (Viagra) simvastatin (Zocor) sirolimus (Rapamune)5 terfenadine (Seldane)1,9 ziprasidone (Geodon)5 Use with grapefruit with caution albendazole (Albenza) carbamazepine (Tegretol)3 clomipramine (Anafranil)8 cyclosporine (Neoral)2,3,8 dextromethorphan diazepam (Valium)8 dofetilide (Tikosyn)5 erythromycin (E-mycin) felodipine (Renedil, Plendil) fexofenadine (Allegra)10 gefitinib (Iressa) imatinib mesylate (Gleevec/Glivec) itraconazole (Sporanox)10 losartan (Cozaar) methadone5 methylprednisolone (Medrol)8,9 midazolam (Versed)9 montelukast (Singulair)5 nicardipine (Cardene)8 nifedipine (Procardia) nimodipine (Nimotop) nisoldipine (Sular) pranidipine quetiapine (Seroquel)5 quinidine (Ouinaglute, Quinidex)8 quinine saquinavir (Invirase)2 sertraline (Zoloft) tacrolimus (FK-506, Prograf)2,3,8 tamoxifen (Nolvadex)5 tamsulosin (Flomax)5 tolterodine (Detrol)5 triazolam (Halcion) Medications with no significant interaction with grapefruit Drugs in this section have all been studied with Grapefruit, and found to have minimal/negligible interaction alprazolam (Xanax)4 amlodipine (Norvasc)4 amprenavir (Agenerase)4,10 caffeine4 carvedilol (Coreg)4 clarithromycin (Biaxin) clozapine (Clozaril)4 digoxin (Lanoxin) diltiazem (Cardizem)4 17-B estradiol4 ethinyl estradiol 4,8 haloperidol (Haldol) omeprazole (Losec, Prilosec)4 phenytoin (Dilantin) prednisone (Deltasone) scopolamine (Hyoscine)4 theophylline (Theo-Dur, Uniphyl) verapamil (Calan, Isoptin, Verelan) Medications considered safe for use with grapefruit cetirizine (Zyrtec, Reactine)6 desloratadine (Aerius, Clarinex)7 fluvastatin (Lescol)7 loratadine (Claritin)6 pravastatin (Pravachol)7 rosuvastatin (Crestor)7 Answered by Candis Cogdill 1 year ago.

Cozaar And Grapefruit Answered by Cole Rosek 1 year ago.

Thanks for the answers! Answered by Caren Brynga 1 year ago.


Can orange and apple juice interfere with some medications?
Asked by Hortense Votsmier 1 year ago.

it is a theory. Not sure if its fact or fiction, but its possible Answered by April Bunche 1 year ago.


I am on High Blood pressuremedicine(diovan hct).is it safe for me to drink chamomile tea everyday?
I am on high blood pressure medicine(diovan hct).is it safe for me to drink chamomile tea everyday? Asked by Wilson Peraha 1 year ago.

Chamomile is an extremely mild and gentle relaxant herb. The only negative reaction I am aware of with it is that some people who are allergic to ragweed, goldenrod (Solidago), asters, chrysanthemums are also allergic to chamomile. This is taken from www.hbcprotocols.com/sleep/chamomile.htm... Prescription Drugs Chamomile contains chemicals that may increase the time blood needs to clot. When it is taken with antiplatelet or anticoagulant drugs, the effect of the antiplatelet or anticoagulant may be increased, resulting in uncontrolled bleeding. Antiplatelet drugs include Plavix and Ticlid Anticoagulants include heparin and warfarin When chamomile is used with prescription drugs that promote sleepiness, the effects of the prescription drug may be exaggerated, resulting in sedation or mental impairment. Prescription drugs that can cause sleepiness include: Anticonvulsants such as carbamazepine (Tegretol), phenytoin (Dilantin), and valproic acid (Depakote) Barbiturates such as phenobarbital Benzodiazepines such as alprazolam (Xanax) and diazepam (Valium) Drugs for insomnia such as zaleplon (Sonata) and zolpidem (Ambien) Tricyclic antidepressants such as amitriptyline (Elavil), amoxapine, doxepin and nortriptyline Chamomile is broken down by certain enzymes in the liver, therefore it may interfere with the use of prescription drugs that are processed by the same enzymes. These drugs may include: Allergy drugs such as fexofenadine (Seldane) Antifungal drugs such as itraconazole (Sporanox) and ketoconazole (Nizoral) Cancer drugs such as etoposide (VePesid), paclitaxel (Onxol, Taxol), vinblastine, or vincristine Drugs for high cholesterol such as lovastatin (Mevacor) Oral contraceptives Non-prescription Drugs Chamomile can affect the ability of blood to clot after. Aspirin can also delay clotting, so chamomile should not be taken at the same time as aspirin. The sleep-producing effects of over-the-counter products containing diphenhydramine can be enhanced by taking chamomile concurrently. Diphenhydramine is contained in many over-the-counter sleep aids as well as in some cough and cold products, therefore caution should be used when taking these medications with chamomile because excessive drowsiness may result. Answered by Lorene Kressierer 1 year ago.

Your best (and safest) bet would be to ask a pharmacist if there are any interactions listed between the drugs and supplements you're taking. Doctors and pharmacists both have access to a database of drug and supplement interactions and they can tell you quickly if you can safely take them together or not.... anyone here will just have a best guess from searching on the internet (which isn't always accurate, as we all know) ;-) Good luck! Answered by Lisa Zeegers 1 year ago.

It would specify this on the medication info leaflet if it was'nt safe. Like on my cholesterol medication it says dont have Grapefruit juice. Answered by Willie Mollet 1 year ago.

Hi all i know is that some tea doesn't work well with vitamins it actually bugger up the vitamin so i recommend that see your Doctor/pharmacist Answered by Nita Maroon 1 year ago.


How do drugs halt mitosis?
Maligant tumors are sometimes treated with drugs that halt mitosis, and thus stop the production of new cancer cells. two such drugs, vincristine sulfate and vinblastine sulfate, interfere with the formation of spindle fibers. how could this action halt mitosis?Some drugs can also interfere with DNA... Asked by Junko Tarzia 1 year ago.

Maligant tumors are sometimes treated with drugs that halt mitosis, and thus stop the production of new cancer cells. two such drugs, vincristine sulfate and vinblastine sulfate, interfere with the formation of spindle fibers. how could this action halt mitosis? Some drugs can also interfere with DNA synthesis in treated cells. How could this action halt mitosis? Answered by Curt Stroud 1 year ago.

Catagories of Chemotherapy Drugs: In general, chemotherapy agents can be divided into three main categories based on their mechanism of action. Stop the synthesis of pre DNA molecule building blocks: These agents work in a number of different ways. DNA building blocks are folic acid, heterocyclic bases, and nucleotides, which are made naturally within cells. All of these agents work to block some step in the formation of nucleotides or deoxyribonucleotides (necessary for making DNA). When these steps are blocked, the nucleotides, which arethe building blocks of DNA and RNA, can not be synthesized. Thus the cells can not replicate because they cannot make DNA without the nucleotides. Examples of drugs in this class include 1) methotrexate (Abitrexate®),2) fluorouracil (Adrucil®), 3) hydroxyurea (Hydrea®), and 4) mercaptopurine (Purinethol®). Directly damage the DNA in the nucleus of the cell: These agents chemically damage DNA and RNA. They disrupt replication of the DNA and either totally halt replication or cause the manufacture of nonsense DNA or RNA (i.e. the new DNA or RNA does not code for anything useful). Examples of drugs in this class include cisplatin (Platinol®) and 7) antibiotics - daunorubicin (Cerubidine®), doxorubicin (Adriamycin®), and etoposide (VePesid®). Effect the synthesis or breakdown of the mitotic spindles: Mitotic spindles serve as molecular railroads with "North and South Poles" in the cell when a cell starts to divide itself into two new cells. These spindles are very important because they help to split the newly copied DNA such that a copy goes to each of the two new cells during cell division. These drugs disrupt the formation of these spindles and therefore interrupt cell division. Examples of drugs in this class of 8) miotic disrupters include: Vinblastine (Velban®), Vincristine (Oncovin®) and Pacitaxel (Taxol®). Answered by Jinny Zalamea 1 year ago.

Drugs that interfere with the normal progression of mitosis belong to the most successful chemotherapeutic compounds currently used for anti-cancer treatment. Classically, these drugs are represented by microtubule binding drugs that inhibit the function of the mitotic spindle in order to halt the cell cycle in mitosis and to induce apoptosis in tumor cells. However, these compounds act not only on proliferating tumor cells, but exhibit significant side effects on non-proliferating cells including neurons that are highly dependent on intracellular transport processes mediated by microtubules. Therefore, there is a particular interest in developing novel anti-mitotic drugs that target non-microtubule structures. In fact, recently several novel drugs that target mitotic kinesins or the Aurora and polo-like kinases have been developed and are currently tested in clinical trials. In addition, approaches of cell cycle checkpoint abrogation during mitosis and at the G2/M transition inducing mitosis-associated tumor cell death are promising new strategies for anti-cancer therapy. It is expected that this "next generation" of anti-mitotic drugs will be as successful as the classical anti-microtubule drugs, while avoiding some of the adverse side effect Answered by Necole Kannady 1 year ago.

spindle fibers are used to move the chromosome and orgenelles to opposite sides if you cant dupliccate DNA then you cannot spilt a chromosome for the daughter cells Answered by Collene Landruth 1 year ago.


What is the Generic name for?
Anadrol Casodex Cialis VePESID Asked by Gale Lifland 1 year ago.

Anadrol- Oxymetholone Casodex- Bicalutamide Cialis- Tadalafil VePESID- Etoposide Answered by Catherin Slinkard 1 year ago.

La disfunción eréctil es la incapacidad del hombre para lograr y mantener una erección suficiente tanto para su propia y por las necesidades de los socios en la gestión de las relaciones sexuales. Si usted sufre de disfunción eréctil debe intentar esta solución natural que ya ha resuelto este problema para muchos hombres de todo el mundo! [Link] Answered by Bettyann Preheim 1 year ago.

anadrol = oxymetholone casodex = bicalutamide cialis = tadalafil vepesid = etoposide Answered by Mary Wehrle 1 year ago.

go to wikipedia then you will find out. that is the best way. Answered by Shanon Bastianelli 1 year ago.


Where does the name VP16 come from?
The chemotherapy agent etoposide is also known as VP16. What is the history of the name VP16? Asked by Julienne Bohac 1 year ago.

Toposar, VePesid, and Etopophos are trade names for Etoposide. VP-16 and Etoposide Phosphate are other names for Etoposide. In some cases, health care professionals may use the trade names Toposar, VePesid, and Etopophos or other names VP-16 and Etoposide Phosphate when referring to the generic drug name Etoposide. Drug type: VP-16 is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. This medication is classified as a "plant alkaloid" and "topoisomerase II inhibitor." Answered by Branda Rumburd 1 year ago.


Is Zyrtec safe with grapefruit?
Asked by Lawana Scrobola 1 year ago.

yes its safe in case youre interested: (disregard the numbers.. they were my own notes) Medications that should be avoided with grapefruit amiodarone (Cordarone)8 astemizole (Hismanal)5,9 atorvastatin (Lipitor) budesonide (Entocort)8 buspirone (BuSpar) cerivastatin (Baycol)5,9 cilostazol (Pletal)5 cisapride (Propulsid, Prepulsid)9 colchicine 5 eletriptan (Relpax)5 etoposide (Vepesid)8,10 halofantrine (Halfan) indinavir (Crixivan)10 lovastatin (Mevacor) mifepristone (Mifeprex)5 pimozide (Orap)5 sildenafil (Viagra) simvastatin (Zocor) sirolimus (Rapamune)5 terfenadine (Seldane)1,9 ziprasidone (Geodon)5 Use with grapefruit with caution albendazole (Albenza) carbamazepine (Tegretol)3 clomipramine (Anafranil)8 cyclosporine (Neoral)2,3,8 dextromethorphan diazepam (Valium)8 dofetilide (Tikosyn)5 erythromycin (E-mycin) felodipine (Renedil, Plendil) fexofenadine (Allegra)10 gefitinib (Iressa) imatinib mesylate (Gleevec/Glivec) itraconazole (Sporanox)10 losartan (Cozaar) methadone5 methylprednisolone (Medrol)8,9 midazolam (Versed)9 montelukast (Singulair)5 nicardipine (Cardene)8 nifedipine (Procardia) nimodipine (Nimotop) nisoldipine (Sular) pranidipine quetiapine (Seroquel)5 quinidine (Ouinaglute, Quinidex)8 quinine saquinavir (Invirase)2 sertraline (Zoloft) tacrolimus (FK-506, Prograf)2,3,8 tamoxifen (Nolvadex)5 tamsulosin (Flomax)5 tolterodine (Detrol)5 triazolam (Halcion) Medications with no significant interaction with grapefruit Drugs in this section have all been studied with Grapefruit, and found to have minimal/negligible interaction alprazolam (Xanax)4 amlodipine (Norvasc)4 amprenavir (Agenerase)4,10 caffeine4 carvedilol (Coreg)4 clarithromycin (Biaxin) clozapine (Clozaril)4 digoxin (Lanoxin) diltiazem (Cardizem)4 17-B estradiol4 ethinyl estradiol 4,8 haloperidol (Haldol) omeprazole (Losec, Prilosec)4 phenytoin (Dilantin) prednisone (Deltasone) scopolamine (Hyoscine)4 theophylline (Theo-Dur, Uniphyl) verapamil (Calan, Isoptin, Verelan) Medications considered safe for use with grapefruit cetirizine (Zyrtec, Reactine)6 desloratadine (Aerius, Clarinex)7 fluvastatin (Lescol)7 loratadine (Claritin)6 pravastatin (Pravachol)7 rosuvastatin (Crestor)7 Answered by Marilou Darwich 1 year ago.

Cozaar And Grapefruit Answered by Laurence Sydney 1 year ago.

Thanks for the answers! Answered by Lianne Orender 1 year ago.


Can orange and apple juice interfere with some medications?
Asked by Maryln Macaulay 1 year ago.

it is a theory. Not sure if its fact or fiction, but its possible Answered by Roslyn Thiem 1 year ago.


I am on High Blood pressuremedicine(diovan hct).is it safe for me to drink chamomile tea everyday?
I am on high blood pressure medicine(diovan hct).is it safe for me to drink chamomile tea everyday? Asked by Jaleesa Vesey 1 year ago.

Chamomile is an extremely mild and gentle relaxant herb. The only negative reaction I am aware of with it is that some people who are allergic to ragweed, goldenrod (Solidago), asters, chrysanthemums are also allergic to chamomile. This is taken from www.hbcprotocols.com/sleep/chamomile.htm... Prescription Drugs Chamomile contains chemicals that may increase the time blood needs to clot. When it is taken with antiplatelet or anticoagulant drugs, the effect of the antiplatelet or anticoagulant may be increased, resulting in uncontrolled bleeding. Antiplatelet drugs include Plavix and Ticlid Anticoagulants include heparin and warfarin When chamomile is used with prescription drugs that promote sleepiness, the effects of the prescription drug may be exaggerated, resulting in sedation or mental impairment. Prescription drugs that can cause sleepiness include: Anticonvulsants such as carbamazepine (Tegretol), phenytoin (Dilantin), and valproic acid (Depakote) Barbiturates such as phenobarbital Benzodiazepines such as alprazolam (Xanax) and diazepam (Valium) Drugs for insomnia such as zaleplon (Sonata) and zolpidem (Ambien) Tricyclic antidepressants such as amitriptyline (Elavil), amoxapine, doxepin and nortriptyline Chamomile is broken down by certain enzymes in the liver, therefore it may interfere with the use of prescription drugs that are processed by the same enzymes. These drugs may include: Allergy drugs such as fexofenadine (Seldane) Antifungal drugs such as itraconazole (Sporanox) and ketoconazole (Nizoral) Cancer drugs such as etoposide (VePesid), paclitaxel (Onxol, Taxol), vinblastine, or vincristine Drugs for high cholesterol such as lovastatin (Mevacor) Oral contraceptives Non-prescription Drugs Chamomile can affect the ability of blood to clot after. Aspirin can also delay clotting, so chamomile should not be taken at the same time as aspirin. The sleep-producing effects of over-the-counter products containing diphenhydramine can be enhanced by taking chamomile concurrently. Diphenhydramine is contained in many over-the-counter sleep aids as well as in some cough and cold products, therefore caution should be used when taking these medications with chamomile because excessive drowsiness may result. Answered by Tiffany Heltzel 1 year ago.

Your best (and safest) bet would be to ask a pharmacist if there are any interactions listed between the drugs and supplements you're taking. Doctors and pharmacists both have access to a database of drug and supplement interactions and they can tell you quickly if you can safely take them together or not.... anyone here will just have a best guess from searching on the internet (which isn't always accurate, as we all know) ;-) Good luck! Answered by Alvera Rabasca 1 year ago.

It would specify this on the medication info leaflet if it was'nt safe. Like on my cholesterol medication it says dont have Grapefruit juice. Answered by Janessa Silvan 1 year ago.

Hi all i know is that some tea doesn't work well with vitamins it actually bugger up the vitamin so i recommend that see your Doctor/pharmacist Answered by Eunice Foskey 1 year ago.


How do drugs halt mitosis?
Maligant tumors are sometimes treated with drugs that halt mitosis, and thus stop the production of new cancer cells. two such drugs, vincristine sulfate and vinblastine sulfate, interfere with the formation of spindle fibers. how could this action halt mitosis?Some drugs can also interfere with DNA... Asked by Taren Bernon 1 year ago.

Maligant tumors are sometimes treated with drugs that halt mitosis, and thus stop the production of new cancer cells. two such drugs, vincristine sulfate and vinblastine sulfate, interfere with the formation of spindle fibers. how could this action halt mitosis? Some drugs can also interfere with DNA synthesis in treated cells. How could this action halt mitosis? Answered by Aisha Kriske 1 year ago.

Catagories of Chemotherapy Drugs: In general, chemotherapy agents can be divided into three main categories based on their mechanism of action. Stop the synthesis of pre DNA molecule building blocks: These agents work in a number of different ways. DNA building blocks are folic acid, heterocyclic bases, and nucleotides, which are made naturally within cells. All of these agents work to block some step in the formation of nucleotides or deoxyribonucleotides (necessary for making DNA). When these steps are blocked, the nucleotides, which arethe building blocks of DNA and RNA, can not be synthesized. Thus the cells can not replicate because they cannot make DNA without the nucleotides. Examples of drugs in this class include 1) methotrexate (Abitrexate®),2) fluorouracil (Adrucil®), 3) hydroxyurea (Hydrea®), and 4) mercaptopurine (Purinethol®). Directly damage the DNA in the nucleus of the cell: These agents chemically damage DNA and RNA. They disrupt replication of the DNA and either totally halt replication or cause the manufacture of nonsense DNA or RNA (i.e. the new DNA or RNA does not code for anything useful). Examples of drugs in this class include cisplatin (Platinol®) and 7) antibiotics - daunorubicin (Cerubidine®), doxorubicin (Adriamycin®), and etoposide (VePesid®). Effect the synthesis or breakdown of the mitotic spindles: Mitotic spindles serve as molecular railroads with "North and South Poles" in the cell when a cell starts to divide itself into two new cells. These spindles are very important because they help to split the newly copied DNA such that a copy goes to each of the two new cells during cell division. These drugs disrupt the formation of these spindles and therefore interrupt cell division. Examples of drugs in this class of 8) miotic disrupters include: Vinblastine (Velban®), Vincristine (Oncovin®) and Pacitaxel (Taxol®). Answered by Anderson Baugess 1 year ago.

Drugs that interfere with the normal progression of mitosis belong to the most successful chemotherapeutic compounds currently used for anti-cancer treatment. Classically, these drugs are represented by microtubule binding drugs that inhibit the function of the mitotic spindle in order to halt the cell cycle in mitosis and to induce apoptosis in tumor cells. However, these compounds act not only on proliferating tumor cells, but exhibit significant side effects on non-proliferating cells including neurons that are highly dependent on intracellular transport processes mediated by microtubules. Therefore, there is a particular interest in developing novel anti-mitotic drugs that target non-microtubule structures. In fact, recently several novel drugs that target mitotic kinesins or the Aurora and polo-like kinases have been developed and are currently tested in clinical trials. In addition, approaches of cell cycle checkpoint abrogation during mitosis and at the G2/M transition inducing mitosis-associated tumor cell death are promising new strategies for anti-cancer therapy. It is expected that this "next generation" of anti-mitotic drugs will be as successful as the classical anti-microtubule drugs, while avoiding some of the adverse side effect Answered by Sid Millhiser 1 year ago.

spindle fibers are used to move the chromosome and orgenelles to opposite sides if you cant dupliccate DNA then you cannot spilt a chromosome for the daughter cells Answered by Lady Hudkins 1 year ago.


What is the Generic name for?
Anadrol Casodex Cialis VePESID Asked by Vernie Cicale 1 year ago.

Anadrol- Oxymetholone Casodex- Bicalutamide Cialis- Tadalafil VePESID- Etoposide Answered by Denna Zanella 1 year ago.

La disfunción eréctil es la incapacidad del hombre para lograr y mantener una erección suficiente tanto para su propia y por las necesidades de los socios en la gestión de las relaciones sexuales. Si usted sufre de disfunción eréctil debe intentar esta solución natural que ya ha resuelto este problema para muchos hombres de todo el mundo! [Link] Answered by Magdalene Anstey 1 year ago.

anadrol = oxymetholone casodex = bicalutamide cialis = tadalafil vepesid = etoposide Answered by Krysta Kalaf 1 year ago.

go to wikipedia then you will find out. that is the best way. Answered by Crystal Ringuette 1 year ago.


Where does the name VP16 come from?
The chemotherapy agent etoposide is also known as VP16. What is the history of the name VP16? Asked by Rae Delagol 1 year ago.

Toposar, VePesid, and Etopophos are trade names for Etoposide. VP-16 and Etoposide Phosphate are other names for Etoposide. In some cases, health care professionals may use the trade names Toposar, VePesid, and Etopophos or other names VP-16 and Etoposide Phosphate when referring to the generic drug name Etoposide. Drug type: VP-16 is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. This medication is classified as a "plant alkaloid" and "topoisomerase II inhibitor." Answered by Tilda Combe 1 year ago.


Is Zyrtec safe with grapefruit?
Asked by Kittie Renner 1 year ago.

yes its safe in case youre interested: (disregard the numbers.. they were my own notes) Medications that should be avoided with grapefruit amiodarone (Cordarone)8 astemizole (Hismanal)5,9 atorvastatin (Lipitor) budesonide (Entocort)8 buspirone (BuSpar) cerivastatin (Baycol)5,9 cilostazol (Pletal)5 cisapride (Propulsid, Prepulsid)9 colchicine 5 eletriptan (Relpax)5 etoposide (Vepesid)8,10 halofantrine (Halfan) indinavir (Crixivan)10 lovastatin (Mevacor) mifepristone (Mifeprex)5 pimozide (Orap)5 sildenafil (Viagra) simvastatin (Zocor) sirolimus (Rapamune)5 terfenadine (Seldane)1,9 ziprasidone (Geodon)5 Use with grapefruit with caution albendazole (Albenza) carbamazepine (Tegretol)3 clomipramine (Anafranil)8 cyclosporine (Neoral)2,3,8 dextromethorphan diazepam (Valium)8 dofetilide (Tikosyn)5 erythromycin (E-mycin) felodipine (Renedil, Plendil) fexofenadine (Allegra)10 gefitinib (Iressa) imatinib mesylate (Gleevec/Glivec) itraconazole (Sporanox)10 losartan (Cozaar) methadone5 methylprednisolone (Medrol)8,9 midazolam (Versed)9 montelukast (Singulair)5 nicardipine (Cardene)8 nifedipine (Procardia) nimodipine (Nimotop) nisoldipine (Sular) pranidipine quetiapine (Seroquel)5 quinidine (Ouinaglute, Quinidex)8 quinine saquinavir (Invirase)2 sertraline (Zoloft) tacrolimus (FK-506, Prograf)2,3,8 tamoxifen (Nolvadex)5 tamsulosin (Flomax)5 tolterodine (Detrol)5 triazolam (Halcion) Medications with no significant interaction with grapefruit Drugs in this section have all been studied with Grapefruit, and found to have minimal/negligible interaction alprazolam (Xanax)4 amlodipine (Norvasc)4 amprenavir (Agenerase)4,10 caffeine4 carvedilol (Coreg)4 clarithromycin (Biaxin) clozapine (Clozaril)4 digoxin (Lanoxin) diltiazem (Cardizem)4 17-B estradiol4 ethinyl estradiol 4,8 haloperidol (Haldol) omeprazole (Losec, Prilosec)4 phenytoin (Dilantin) prednisone (Deltasone) scopolamine (Hyoscine)4 theophylline (Theo-Dur, Uniphyl) verapamil (Calan, Isoptin, Verelan) Medications considered safe for use with grapefruit cetirizine (Zyrtec, Reactine)6 desloratadine (Aerius, Clarinex)7 fluvastatin (Lescol)7 loratadine (Claritin)6 pravastatin (Pravachol)7 rosuvastatin (Crestor)7 Answered by Eileen Binz 1 year ago.

Cozaar And Grapefruit Answered by Lillia Millman 1 year ago.

Thanks for the answers! Answered by Raymonde Lavertu 1 year ago.


Can orange and apple juice interfere with some medications?
Asked by Kelley Syzdek 1 year ago.

it is a theory. Not sure if its fact or fiction, but its possible Answered by Marquetta Guedes 1 year ago.


I am on High Blood pressuremedicine(diovan hct).is it safe for me to drink chamomile tea everyday?
I am on high blood pressure medicine(diovan hct).is it safe for me to drink chamomile tea everyday? Asked by Tien Zagel 1 year ago.

Chamomile is an extremely mild and gentle relaxant herb. The only negative reaction I am aware of with it is that some people who are allergic to ragweed, goldenrod (Solidago), asters, chrysanthemums are also allergic to chamomile. This is taken from www.hbcprotocols.com/sleep/chamomile.htm... Prescription Drugs Chamomile contains chemicals that may increase the time blood needs to clot. When it is taken with antiplatelet or anticoagulant drugs, the effect of the antiplatelet or anticoagulant may be increased, resulting in uncontrolled bleeding. Antiplatelet drugs include Plavix and Ticlid Anticoagulants include heparin and warfarin When chamomile is used with prescription drugs that promote sleepiness, the effects of the prescription drug may be exaggerated, resulting in sedation or mental impairment. Prescription drugs that can cause sleepiness include: Anticonvulsants such as carbamazepine (Tegretol), phenytoin (Dilantin), and valproic acid (Depakote) Barbiturates such as phenobarbital Benzodiazepines such as alprazolam (Xanax) and diazepam (Valium) Drugs for insomnia such as zaleplon (Sonata) and zolpidem (Ambien) Tricyclic antidepressants such as amitriptyline (Elavil), amoxapine, doxepin and nortriptyline Chamomile is broken down by certain enzymes in the liver, therefore it may interfere with the use of prescription drugs that are processed by the same enzymes. These drugs may include: Allergy drugs such as fexofenadine (Seldane) Antifungal drugs such as itraconazole (Sporanox) and ketoconazole (Nizoral) Cancer drugs such as etoposide (VePesid), paclitaxel (Onxol, Taxol), vinblastine, or vincristine Drugs for high cholesterol such as lovastatin (Mevacor) Oral contraceptives Non-prescription Drugs Chamomile can affect the ability of blood to clot after. Aspirin can also delay clotting, so chamomile should not be taken at the same time as aspirin. The sleep-producing effects of over-the-counter products containing diphenhydramine can be enhanced by taking chamomile concurrently. Diphenhydramine is contained in many over-the-counter sleep aids as well as in some cough and cold products, therefore caution should be used when taking these medications with chamomile because excessive drowsiness may result. Answered by Clyde Bielicki 1 year ago.

Your best (and safest) bet would be to ask a pharmacist if there are any interactions listed between the drugs and supplements you're taking. Doctors and pharmacists both have access to a database of drug and supplement interactions and they can tell you quickly if you can safely take them together or not.... anyone here will just have a best guess from searching on the internet (which isn't always accurate, as we all know) ;-) Good luck! Answered by Cher Attanasio 1 year ago.

It would specify this on the medication info leaflet if it was'nt safe. Like on my cholesterol medication it says dont have Grapefruit juice. Answered by Augustine Weakley 1 year ago.

Hi all i know is that some tea doesn't work well with vitamins it actually bugger up the vitamin so i recommend that see your Doctor/pharmacist Answered by Juanita Quartieri 1 year ago.


How do drugs halt mitosis?
Maligant tumors are sometimes treated with drugs that halt mitosis, and thus stop the production of new cancer cells. two such drugs, vincristine sulfate and vinblastine sulfate, interfere with the formation of spindle fibers. how could this action halt mitosis?Some drugs can also interfere with DNA... Asked by Babara Achor 1 year ago.

Maligant tumors are sometimes treated with drugs that halt mitosis, and thus stop the production of new cancer cells. two such drugs, vincristine sulfate and vinblastine sulfate, interfere with the formation of spindle fibers. how could this action halt mitosis? Some drugs can also interfere with DNA synthesis in treated cells. How could this action halt mitosis? Answered by Willena Marotto 1 year ago.

Catagories of Chemotherapy Drugs: In general, chemotherapy agents can be divided into three main categories based on their mechanism of action. Stop the synthesis of pre DNA molecule building blocks: These agents work in a number of different ways. DNA building blocks are folic acid, heterocyclic bases, and nucleotides, which are made naturally within cells. All of these agents work to block some step in the formation of nucleotides or deoxyribonucleotides (necessary for making DNA). When these steps are blocked, the nucleotides, which arethe building blocks of DNA and RNA, can not be synthesized. Thus the cells can not replicate because they cannot make DNA without the nucleotides. Examples of drugs in this class include 1) methotrexate (Abitrexate®),2) fluorouracil (Adrucil®), 3) hydroxyurea (Hydrea®), and 4) mercaptopurine (Purinethol®). Directly damage the DNA in the nucleus of the cell: These agents chemically damage DNA and RNA. They disrupt replication of the DNA and either totally halt replication or cause the manufacture of nonsense DNA or RNA (i.e. the new DNA or RNA does not code for anything useful). Examples of drugs in this class include cisplatin (Platinol®) and 7) antibiotics - daunorubicin (Cerubidine®), doxorubicin (Adriamycin®), and etoposide (VePesid®). Effect the synthesis or breakdown of the mitotic spindles: Mitotic spindles serve as molecular railroads with "North and South Poles" in the cell when a cell starts to divide itself into two new cells. These spindles are very important because they help to split the newly copied DNA such that a copy goes to each of the two new cells during cell division. These drugs disrupt the formation of these spindles and therefore interrupt cell division. Examples of drugs in this class of 8) miotic disrupters include: Vinblastine (Velban®), Vincristine (Oncovin®) and Pacitaxel (Taxol®). Answered by Joana Goethe 1 year ago.

Drugs that interfere with the normal progression of mitosis belong to the most successful chemotherapeutic compounds currently used for anti-cancer treatment. Classically, these drugs are represented by microtubule binding drugs that inhibit the function of the mitotic spindle in order to halt the cell cycle in mitosis and to induce apoptosis in tumor cells. However, these compounds act not only on proliferating tumor cells, but exhibit significant side effects on non-proliferating cells including neurons that are highly dependent on intracellular transport processes mediated by microtubules. Therefore, there is a particular interest in developing novel anti-mitotic drugs that target non-microtubule structures. In fact, recently several novel drugs that target mitotic kinesins or the Aurora and polo-like kinases have been developed and are currently tested in clinical trials. In addition, approaches of cell cycle checkpoint abrogation during mitosis and at the G2/M transition inducing mitosis-associated tumor cell death are promising new strategies for anti-cancer therapy. It is expected that this "next generation" of anti-mitotic drugs will be as successful as the classical anti-microtubule drugs, while avoiding some of the adverse side effect Answered by Yon Stavsvick 1 year ago.

spindle fibers are used to move the chromosome and orgenelles to opposite sides if you cant dupliccate DNA then you cannot spilt a chromosome for the daughter cells Answered by Kristopher Lapiana 1 year ago.


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