Application Information

This drug has been submitted to the FDA under the reference 011838/002.

Names and composition

"TOFRANIL" is the commercial name of a drug composed of IMIPRAMINE HYDROCHLORIDE.

Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
011838/002 TOFRANIL IMIPRAMINE HYDROCHLORIDE INJECTABLE/INJECTION 12.5MG per ML
087844/001 TOFRANIL IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 10MG
087845/001 TOFRANIL IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 25MG
087846/001 TOFRANIL IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 50MG

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
011836/003 PRESAMINE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 25MG
011836/006 PRESAMINE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 10MG
011836/007 PRESAMINE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 50MG
011838/002 TOFRANIL IMIPRAMINE HYDROCHLORIDE INJECTABLE/INJECTION 12.5MG per ML
017895/001 JANIMINE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 10MG
017895/002 JANIMINE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 25MG
017895/003 JANIMINE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 50MG
040751/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 50MG
040903/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 10MG
040903/002 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 25MG
040903/003 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 50MG
081048/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 10MG
081049/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 25MG
081050/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 50MG
083729/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 10MG
083729/003 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 50MG
083729/004 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 25MG
083745/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 25MG
083799/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 10MG
083799/002 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 25MG
083799/003 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 50MG
083827/001 PRAMINE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 10MG
083827/002 PRAMINE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 25MG
083827/003 PRAMINE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 50MG
084252/002 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 25MG
084869/002 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 25MG
084936/002 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 10MG
084937/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 50MG
085133/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 50MG
085200/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 10MG
085220/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 10MG
085221/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 50MG
085875/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 10MG
085877/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 50MG
085878/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 25MG
086267/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 25MG
086268/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 50MG
086269/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 10MG
086765/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE CONCENTRATE/ORAL 25MG per ML
087619/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 25MG
087631/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 50MG
087776/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 25MG
087844/001 TOFRANIL IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 10MG
087845/001 TOFRANIL IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 25MG
087846/001 TOFRANIL IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 50MG
088036/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 10MG
088222/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 25MG
088223/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 50MG
088262/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 25MG
088276/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 50MG
088292/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 10MG
089422/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 10MG
089497/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 25MG
090441/001 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 50MG
090441/002 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 10MG
090441/003 IMIPRAMINE HYDROCHLORIDE IMIPRAMINE HYDROCHLORIDE TABLET/ORAL 25MG

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Answered questions

Does anyone knows about the medicine lyrica and tofranil to Fibromyalgia?
I take tofranil 100mg and lyrica 225mg a day but I still can feel the pain.Does anybody know hoe many mg can I take these two medicine to the most? Asked by Halley Englebert 1 year ago.

Tofranil is a tricyclic antidepressant--one of the classes of drugs used for FMS---but current thinking is that SNRI meds are better.....antidepressant meds work on brain chemicals--which also seem to be a cause of fms symtpoms The meds don't work for everyone...and there are different meds to try ...and a big problem is that many people that they were tested on don't really have fms----they were falsely diagnosed with it....that is something you must continuously research for yourself--if you actually have fms--or something else more treatable. fms is real, but it is actually rare..it is HIGHLY overdiagnosed...i know 4 others that were diagnosed with it--NONE really had it (confirmed that they were misdiagnosed)..most people have something else---some are not physically ill at all. even when you supposedly had all the tests (there are hundreds if not thousands of possible tests and docs often miss positive results in tests they do) and even when you have been to multiple so called specialists...most get it wrong... doctors have missed a number of things that should have been noticed it tests..severe OA in an xray was missed by 4 doctors over 2 years until I pointed it out...they just kept telling me they didn't see a fracture...there is something seriously wrong with my knee--its been injured 3 times---including swelling..docs keep telling me nothing is wrong....i lost the vision in my left eye due to optic nerve damage when I was 5---went to the eye doctor every year--never noticed --and he came highly recommended--a new doc when I was 13 noticed..the damage was easily seen...last June I had a positive blood test result--doc blew it off..September I started getting sicker...January I couldn't function anymore---i kept researching and found the results were significant--made the appointment with the specialists--and got better 2.5 weeks later after suffering for 6 months because the doc missed an important blood test result..IT HAPPENS ALL THE TIME they use fms as a general label for pain...even if they know the pain is due to another condition such as Lymes or MS....or when they are too lazy to put any effort into finding a diagnosis..It is NOT a general label for pain. one major issue is hypothyroid or other thyroid issues.....the in range number is too high--people actually have hypothyroid symtpoms at 3.0....but that is supposedly normal. there are many other things they miss vitamin d deficiency/iron deficiency anemia, lymes (look up lyme literate MD), ms, chiari malformation, celiac, etc FMS is NOT a thyroid issue, cervical spine issue, dehydration...There is NO inflammation with fms. It is NOT due to a vitamin deficiency. i deal with it my educating myself and being open to the possibility it is something else---continuing to research any lead--even though I have been to 2 top specialists..and 12 years of research seems to indicate that the diagnosis is correct MANY people on here have clearly described a condition other than FMS, but have been diagnosed with it…. even after going to a number of 'experts' Source(s): personal experience, extensive research, meeting with 2 top respected researchers, participating in research...people who choose to remain ignorant get what they deserve OA is localized to my foot and is a result of an injury 10 years after fms symptoms started. The knee issue started with an injury 8 YEARS after the fms symptoms and is also a localized issue I had EXCELLENT results on thyroid tests for years prior to actually developing the condition…so I can be sure that wasn’t the problem for the previous 30+ years I had fms symptoms. Even though the thyroid is ‘better’ I still have severe fms symptoms…for example, the other day, it was very painful just using my muscles to turn pages… Answered by Clair Delcambre 1 year ago.

Do not increase the dosage on either of the two medications without checking with your physician. Tofranil ia an antidepressant that has been shown to help decrease the pain of fibromyalgia. It is not a pain medication, but is used for pain control with some chronic conditions. It takes 4-6 weeks to develop the full effect of Tofrinil. Lyrica can cause side effects at higher dosages, but should grant considerable pain relief at the dosage you describe. You may not be pain free, but you should be experiencing marked improvement. You can address breakthrough pain with your prescribing physician, but the goal with fibromyalgia is improvement. It may be unrealistic to expect no discomfort at all. Answered by Ty Helsey 1 year ago.

Tofranil isn't really for pain I don't think. I was prescribed tofranil, paxil, and ellivil for severe depression, and an anger disorder. I'm no doctor Answered by Lise Hutson 1 year ago.

Always check with your doctor before changing your medications. My friend has pain medications in addition to the ones to control fibromyalgia itself. She actually has a doctor just for pain management. You may want to ask your doctor specifically for pain medications and if they won't help you look for someone who will. If you want to find out more about fibromyalgia you may want to check out my website below. Answered by Lisabeth Stopyra 1 year ago.


How long do withdrawl symptoms for tofranil last?
I was on 25mg down from 50 and ive stopped taking them. Ive been getting dizzy. Please straight answers only i have a baby and they were making it hard to get up in the morning and now i feel heaps better. I stopped taking them 4 days ago. Asked by Robin Tonner 1 year ago.

I am glad you stopped taking Tofranil. I think this was one of the older antidepressants. If you still need to take medication, there are newer ones that can help make you feel better. I took Tofranil for about ten years and it didn't help me very much This was before all the newer medications came on the market. Best Wishes. I am glad you are feeling better. Answered by Sarita Kukucka 1 year ago.


Anyone had good bad experiences with tofranil?
psy wants me to try tofranil for depression.. anyone have anything to share positive or negative Asked by Emmaline Perschall 1 year ago.

That is a very old antidepressant also known as Imipramine. I took it for about eight years. At that time there weren't many medications for doctors to choose from. It was alright at that time. I believe the newer antidepressants have helped me feel better. I take Cymbalta right now. I would never want to go back to taking Tofranil. I hope you doctor has a good understanding about the newer medications being used today. I hope you find what works best for you. Good Luck. Answered by Bobette Claybrooks 1 year ago.

My youngster age son used to be on imiprimine for awhile. I followed him from the streets of Manila wherein he used to be a thief, drug addict and little one prostitute. He had ADHD, a hair cause mood and used to be in most cases bipolar besides that wasn't a phrase then. He used to be unattainable to manipulate, suicidal, tremendously violent. Drs had him on more than a few meds. They advised me imiprimine used to be a hazardous difficult drug for adults however used to be OK for youngsters (??!!) He did not take it very lengthy considering the fact that it made him sleep in institution. I want I'd recognized approximately antidepressants at the moment. I'm certain he might have performed bigger with the ones. Answered by Iris Brickle 1 year ago.


I'm considering taking Elavil or Tofranil for depression. Does anyone have any experiences with either?
I've been using Celexa but it's been relatively ineffective. I've tried Wellbutrin, but I can't take it anymore. I've heard that either one of these older classes of antidepressants are still a solid choice, but because they're older, they have a higher incidence of side effects. Have you or anyone you know taken... Asked by Carmen Maile 1 year ago.

I've been using Celexa but it's been relatively ineffective. I've tried Wellbutrin, but I can't take it anymore. I've heard that either one of these older classes of antidepressants are still a solid choice, but because they're older, they have a higher incidence of side effects. Have you or anyone you know taken these medications? And how would they rate their experiences? Answered by Dovie Esco 1 year ago.

I take Tofranil. Have taken it for the last 22 years or so. It and therapy saved my life. Take the entire dose at night - it also acts as a sleeper for me. Some dry mouth still - but the majority of the side effects were only at the beginning and went away after a time. Was there a particular question you had? Will check back. Answered by Ariel Nayes 1 year ago.

My husband took Tofranil, they worked well but the side affects sucked, he was light headed, when he slept he would jolt a lot in his sleep,constipated and NO sex drive. Everyone is different but this was no good for him, he now takes Anafranil which seems ok for him. Answered by Gertha Kiss 1 year ago.

The only thing i know is that older first generation or second generation medications have ALOT of side effects. if they help you though, they might weigh out. Answered by Madeline Efurd 1 year ago.

Can i tell you something? I have had depression. The best way to get rid of it is to correct every negative thought you have with a positive thought. Think Positive=No medicine can do that. Answered by Jody Turri 1 year ago.

prozac if your depress otherwise idk Answered by Cherlyn Wycuff 1 year ago.


What are side effects of Tofranil?
Can it cause extreme tiredness? Asked by Raven Barsanti 1 year ago.

Yes. Tofranil is a tricyclic antidepressant and all TCAs cause drowsiness. Talk to your doctor about switching to a different drug. Answered by Georgeanna Nyland 1 year ago.


What is the difference between Tofranil and Tofranil-PM?
Asked by Terrell Olinghouse 1 year ago.

Extract from site listed below...; Tofranil is used to treat depression. It is a member of the family of drugs called tricyclic antidepressants. Tofranil-PM, which is usually taken once daily at bedtime, is approved to treat major depression. Answered by Lolita Gorenberg 1 year ago.

Tofranil-PM is meant to be taken at night. Answered by Ruthe Merriwether 1 year ago.


I was wondering if there were any medications in the Tofranil family?
I have been taking Imipramine for over 24 years now and I do not think it is still working, but i am medication sensitive and I can not take ANYTHING in the Prozac family so I was looking for something to change to that is in that same family of medication that I am taking now. Asked by Camilla Morkve 1 year ago.

Wow, Imipramine, that's an old drug. Ask your doctor, I don't know every drug name off hand. But Tofranil is just a brand name for Imipramine, a tricyclic anti-depressent. Nothing in the SSRI family, what about the SNRI's? Answered by Eldora Ahyou 1 year ago.


My doctor told me to take tofranil when needed?
I was prescribed 10mg Tofranil (Imipramine) and I was curious on the dosage instructions my shrink told me?I looked it up and read that it should be taken daily, and it starts to work after a couple of weeks. My doctor said to take it whenever I had a speech or event that would make my anxiety worse, and the... Asked by Celestina Kosack 1 year ago.

I was prescribed 10mg Tofranil (Imipramine) and I was curious on the dosage instructions my shrink told me? I looked it up and read that it should be taken daily, and it starts to work after a couple of weeks. My doctor said to take it whenever I had a speech or event that would make my anxiety worse, and the tofranil would make me calmer? I'm just confused if it works that way because I can't find anything about it like that? Answered by Sixta Bettino 1 year ago.

I've never heard of using this drug in this way but I see no problem with it. Try it - if it works it should be quite safe on an occasional basis. It can cause drowsiness in some folks so you may want to take a trial dose to see if this is a problem. Answered by Claude Dipilato 1 year ago.

You're apparently taking it for some different indication, perhaps as a sleep aid. It's used on a regular basis, and at considerably higher doses, to treat major depression, but it has many other uses as well. This is why you listen to your doctor instead of trying to glean through too much information, most of it unrelated to you, on the internet. Answered by Jewel Guye 1 year ago.

Either take a little each day or one for a few days before a speech. Answered by Nelly Pollitt 1 year ago.


Does taking Provigil with Tofranil wrong ?
Hello every one,I'm on Tofranil 25 for 3 months now. I have a big problem with much sleep and i'm taking Tofranil as they think of Depression as the cause of much sleep. Now I want to try (Modafinil) Provigil trying to solve the sleep problem. Can I take it with Tofranil without problems ?Q2- If I... Asked by Jacquline Scheumann 1 year ago.

Hello every one, I'm on Tofranil 25 for 3 months now. I have a big problem with much sleep and i'm taking Tofranil as they think of Depression as the cause of much sleep. Now I want to try (Modafinil) Provigil trying to solve the sleep problem. Can I take it with Tofranil without problems ? Q2- If I used Modafinil for about 20 day. Can I leave it directly and try taking Ritalin with no time between ?? Q3- I used Modafinil today for the first time and I have a headache. Is this a sign to leave it or should I give it the chance ? Answered by Millie Belangia 1 year ago.

These are excellent questions that you should be discussing with your prescribing physician and/or pharmacist as they know the drug interactions. If you have a regular doctor (one that you see exclusively) and a single pharmacy you take all your prescriptions to they can catch potential drug interactions. I get the sinking feeling that since you're the one trying to make these decisions that you are not consulting a doctor though and that's very concerning. Yahoo Answers isn't the place to get medical advice - please go see someone who's trained for years in this very area to help you. This is not one area where you want to mess around with amateurs! Answered by Thaddeus Switalski 1 year ago.


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