Application Information

This drug has been submitted to the FDA under the reference 091620/001.

Names and composition

"TIGECYCLINE" is the commercial name of a drug composed of TIGECYCLINE.
It belongs to the class Other antibiotics and is used in Bacterial infections (Infections and Infestations)

Answered questions

Antibiotics - Tygacil (Tigecycline) against severe acne?
Recently a new broad spectrum antibiotic was introduced against MRSA Staph. Cocc. Aureus. I require this drug for my son who has severe acne vulgaris withpustules around his face.We have done a great improvement with Pro Active but the deeplocated furuncles remain. I treated him with Norfloxacin but this... Asked by Mirella Dermody 6 months ago.

Recently a new broad spectrum antibiotic was introduced against MRSA Staph. Cocc. Aureus. I require this drug for my son who has severe acne vulgaris with pustules around his face. We have done a great improvement with Pro Active but the deep located furuncles remain. I treated him with Norfloxacin but this is not the ideal drug for Staph soft tissue infections. During adolescence young men frequently face this problem due to hormonal changes. But his case merits a treatment of full course antibiotics. Where in the US can we obtain it. We are residing abroad and can only obtain a foreign prescription. Answered by Williemae Norfleet 6 months ago.

NO. We are too happy to use Antibiotics for everything now. So when we get really sick we are imuned to them and they dont help. Also you body imunity weakens the more you take antibiotics. So while the product may work to rid you of acne, is it really worth it? There are so many other choices out there. Answered by Golda Dysart 6 months ago.

NATURAL ACNE PROTOCOL 1/ Never, ever touch your face. 2/ Use 3 facecloths to wash your face, one to soap on, one to soap off with very hot water, one to rinse off with ice cold water, in that order, once a day. 3/ If you are under 18 take 5,000 IU of vitamin A once a day with a full meal 4/ If you are over 18 take 5,000 IU of vitamin A twice a day with a full meal. Do not get pregnant while taking vitamin A. Do not take any more, like Accutane, it will stop you growing. 5/ Never, ever. pick, squeeze or pop your spot. Read number 1 again. 6/ Do this for 90 days. 7/ Invest in a brand new pillow and 2 new or more pillow cases to �double bag' your pillow. HOT wash every couple of days. Source: A bit of advice given to me as a teenager, a bit of science as I am studying allergic reactions and vitamin A is a part of that. A bit of research: I sat in a lecture at the back and watched the acne prone pick at their faces, those with the worse acne touched their faces 32 times in an hour, the clearest complexions didn't touch their faces even once. I have circumstantial evidence that acne is the result of dermatophyte transfer from hands to face...where it does not get washed off and is well fed by hormones, sweat a nd oil...just a hypothesis... But it would explain why vitamin A is so effective as vitamin causes skin to remove dermatophytes. The secret is never to touch the spots Tips on how to treat acne and achieve perfect clear skin in as little as 7 days? Answered by Quyen Demirjian 6 months ago.

iv had mild acne and that was bad enough it was such a confidence breaker. i just wanted to cry all the time and not leave the house. it really makes you miserable. id been to the doctors and theyd given me topical treatment but that never made any difference as acne is caused from inside, its not because of dirt or makeup. i read online tho of people having success with the pill dianette so i went to the docs and told her i wanted to try it. she checked my blood pressure and agreed it would be good to try. my skin cleared up wonderfully, my forehead was never greasy and it was lovly and smooth to touch. it was so great to go out and not be thinkn constantly about whether people are looking at ur skin. i even had compliments off people about it. after being on it a year and having near perfect skin i came off it. my skin stayed fine coz i was happy in my job n life etc. but a few wks before startin uni (and around time of the month) i had this huge red bump on my chin. i was petrified my skin would break out and i didnt want that for uni. it would ruin all the confidence id built. so i asked the doc to go back on it. its ok as long as u dont smoke! also i tried a topical antibiotic called Duac which is good to put on spots. if you do try dianette, and i recommend it to anyone suffering. you may feel sick the 1st few days as it is altering ur hormones. also i find it works better if u take it 1st thing in the morning as soon as u wake up, keep it and some water by ur bed! hope this helped! i havent found anythin more successful. coz the truth is no1 wants to faff around with a 20step facial regime every morning! Answered by Santina Melso 6 months ago.

Try an internal Aloe supplement and another with silver for the infection. The aloe rids your body of toxins and the silver will kill any germ alive and decrease the infection inside his skin. I also had severe acne with those deep painful infections on my face but they have cleaned up with these 2 all natural mineral supplements. My problems were also due to hormones. I now just wash my face with plain hot water and take the supplements. I hated the side effects of what the antibiotics were doing (yeast infections -yuck). The supplements are inexpensive, easy to take and have no negative side effects. email me for more info, Id love to help! Answered by Meggan Marano 6 months ago.

Love the Natural approach. Aloe internal supplement and Silver. Thank you. Answered by Georgeann Coccia 6 months ago.

Is there a treatment for MRSA in the cerebrospinal fluid that is resistant to vancomacyn, daptomacyn and zyvox?
The culture shows resistance to all the known antibiotics. Asked by Earnest Yonkers 6 months ago.

Check tigecycline or quinupristin-dalfopristin. Answered by Melva Rivie 6 months ago.

When they tested the fluid, a preliminary result should have shown what antibiotics were resistant, so I would ask to see that. Since mrsa has become increasingly resistant, they are coming up with new antibiotics everyday. You did not mention levaquin, bactrim, and, tobramycin, which have all treatd forms of mrsa, not sure if you would be resistant to those as well, best way to know is to see the culture result Answered by Tameika Hothan 6 months ago.

What is the best antibiotic?
What is the best (one size fits all) antibiotic & penicillin? Example: If the world ended and we were no longer able to get anymore prescriptions, the best antibiotic and penicillin Asked by Jessie Mcdewitt 6 months ago.

There is no "one size fits all antibiotic." The antibiotics that are effective against some of the widest range and/or most resistant of bacteria such as drugs like Zosyn (piperacillin/tazobactam), Timentin (ticarcillin/clavulanate), Tygacil (tigecycline), Teflaro (ceftaroline fosamil), Zyvoxam, Zyvox (linezolid), Cubicin (daptomycin), and many others are excellent (when used properly) but if they were used to treat fairly basic and simple infections that drugs like Keflex (cephalexin), Amoxil (amoxicillin), Pen Vee K (penicillin VK), and other commonly used oral antibiotics could treat then fairly quickly even what are currently the most effective antibiotics would rapidly lose their effectiveness. In many Scandinavian countries they have moved away from using more advanced antibiotics and as a result rarely need them since it is very uncommon for there to be bacteria that can't be treated with basic medication like penicillin, Keflex, or clindamycin. But if I had to pick I would probably say doxycycline or minocycline (unfortunately after they expire they become toxic) however neither is the best of the best, they are both just really good and treat things from acne to anthrax. Answered by Madeline Widmayer 6 months ago.

Each antibiotic had its own use. Like for a toothache you would get penicillin. I don't think there is an antibiotic for "anything" Answered by Rina Gerould 6 months ago.

there is no best or one size fits all antibiotic.....i work in a hospital, if there was a "best" antibiotic, we would use it with every person who needed antibiotics...... Answered by Theron Bohorquez 6 months ago.

there is no one size fits all antibiotic. antibiotics are for bacterial infections,they do nothing for viruses. antibiotics are specific as to what they can affect. Answered by Carmelita Tunison 6 months ago.

Mrsa treatment?
multiple drug resistance staph aureous Asked by Jamison Theodoropoulo 6 months ago.

Methicillin-resistant Staphylococcus aureus (MRSA) are isolates of the bacterium Staphylococcus aureus that have acquired genes encoding antibiotic resistance to all penicillins, including methicillin and other narrow-spectrum β-lactamase-resistant penicillin antibiotics.[1] The first MRSA was discovered in the UK in 1961, but MRSA are now widespread in the hospital setting. MRSA is commonly termed a superbug. MRSA may also be known as oxacillin-resistant Staphylococcus aureus (ORSA) and multiple-resistant Staphylococcus aureus, while non-methicillin resistant strains of S. aureus are sometimes called methicillin-susceptible Staphylococcus aureus (MSSA) if an explicit distinction must be made. Although MRSA has traditionally been seen as a hospital-associated infection, community-acquired MRSA strains have appeared in recent years, notably in the U.S. and Australia.[2] The abbreviations CA-MRSA (community-associated MRSA) and HA-MRSA (hospital-associated MRSA) are now commonly seen in medical literature. TREATMENT: Vancomycin and teicoplanin are glycopeptide antibiotics used to treat MRSA infections.[13] Teicoplanin is a structural congener of vancomycin that has a similar activity spectrum, but a longer half-life (t½).[14] The oral absorption of vancomycin and teicoplanin are very low and must be administered intravenously in order to control systematic infections.[15] One of the problems with vancomycin is not just that its route of administration is inconvenient, but also that it is inferior in terms of its efficacy compared to antistaphylococcal penicillins.[16][17] Several new strains of MRSA have been found showing antibiotic resistance even to vancomycin and teicoplanin; those new evolutions of the MRSA bacteria are dubbed vancomycin intermediate-resistant Staphylococcus aureus (VISA).[18][19] Linezolid, quinupristin/dalfopristin, daptomycin, tigecycline are used to treat more severe infections that do not respond to the glycopeptides such as vancomycin.[20] Gram-positive MRSA infections can be treated with oral agents such as linezolid, rifampicin+fusidic acid, rifampicin+fluoroquinolone, pristinamycin, co-trimoxazole (trimethoprim-sulfamethoxazole), doxycycline or minocycline, and clindamycin.[21] On 18 May 2006, a team of researchers from Merck Pharmaceuticals published in Nature that they had discovered an entirely new type of antibiotic, called platensimycin, and they have demonstrated that it can be used successfully to fight MRSA.[22][23] An entirely different and promising approach is phage therapy (e.g., at the Tbilisi Institute in Georgia), which reports efficacy against up to 95% of tested Staphylococcus isolates.[24] Raw honey dressings are also being successfully used for prevention and treatment of MRSA.[25][26] It has been reported that use of maggots to treat an MRSA infection has been successful. Studies have been done on diabetic patients and the treatment time has been significantly less than that of other standard treatments. Answered by Louisa Vallon 6 months ago.

Dollyhams Health offers two products namely Essential Body Cleansing Kit and StaphCure for treating MRSA. Answered by Wendie Monath 6 months ago.

I was diagnosed with MRSA after hip replacement. I was put on Vancomycin through an IV for several months. I eventually had to have the replacement redone. The infection was still there. The surgeon was able to scrap and cut the infection away. This was nearly a year ago. I still have pain in the hip. Answered by Dustin Fesenmyer 6 months ago.

It's actually Methicillin Resistant Staphylococcus Aureus. If it diagnosed, it means the lab has tested that isolate of bacteria with several antibiotics and found that it resists Methicillin, which is a type of penicillin made with increased activity against S. Aureus. Typical inpatient treatment would include vancomycin intravenously. Typical outpatient treatment would include trimethoprim-sulfamethoxazole and rifampin, or clindamycin. Answered by Angelic Corvin 6 months ago.

I agree with "puncturelumbar". I'd like to add that trimethoprim-sulfamethoxazole (Bactrim, Septra), rifampin (Rifadin) and clindamycin (Cleocin) are also used for in-patients as well as on an out-patient basis. I pass these meds every shift I work. There are other drugs used depending on the site of infection. Two examples of topicals are Bacitracin ointment in the nose and Silvadene cream on an open wound or gastrostomy tube site. Answered by Krystin Kamal 6 months ago.

The Doctor at The Ottawa General say its nothing to worry about and there is nothing they can give you for it, In other words live with it Answered by Freddie Beachum 6 months ago.

Vancomycin is the antibiotic of choice. Answered by Richelle Sperbeck 6 months ago.

check with doctors. Answered by Kathrin Rovira 6 months ago.

What is the treatment and prognosis of acinetodakter bauminnii?
My mother had a stroke and was in ICU for 3 weeks and then she was moved to a skilled nursing facility. She had pneumonia, surgical and hospital borne. The pneumonia has cleared up, but now the doctors say she has this. What is the treatment and outcome? Asked by Alden Varas 6 months ago.

Acinetobacter baumannii is a species of pathogenic bacteria called aerobic gram-negative bacillus and is naturally sensitive to relatively few antibiotics.Multidrug-resistant A. baumannii is a common problem in many hospitals in the US and Europe. First line treatment is with a carbapenem antibiotic such as imipenem, but carbapenem resistance is increasingly common. Other treatment options include polymyxins, tigecycline and aminoglycosides.[8] Answered by Travis Goens 6 months ago.

Explain anti-infective, dis-infectant, and antibiotic differences and functions.?
Asked by Van Debiasi 6 months ago.

Anti-infective: Something capable of acting against infection, by inhibiting the spread of an infectious agent or by killing the infectious agent outright. Anti-infective is a general term that encompasses antibacterials, antibiotics, antifungals, antiprotozoans and antivirals. Disinfectants are antimicrobial agents that are applied to non-living objects to destroy microorganisms, the process of which is known as disinfection. Disinfectants should generally be distinguished from antibiotics that destroy microorganisms within the body, and from antiseptics, which destroy microorganisms on living tissue. Sanitisers are high level disinfectants that kill over 99.9% of a target microorganism in applicable situations. Very few disinfectants and sanitisers can sterilise (the complete elimination of all microorganisms), and those that can depend entirely on their mode of application. Bacterial endospores are most resistant to disinfectants, however some viruses and bacteria also possess some tolerance. An antibiotic is a chemotherapeutic agent that inhibits or abolishes the growth of micro-organisms, such as bacteria, fungi, or protozoans. The term originally referred to any agent with biological activity against living organisms; however, "antibiotic" now is used to refer to substances with anti-bacterial, anti-fungal, or anti-parasitical activity. The first antibiotic compounds used in modern medicine were produced and isolated from living organisms, such as the penicillin class produced by fungi in the genus Penicillium, or streptomycin from bacteria of the genus Streptomyces. With advances in organic chemistry many antibiotics are now also obtained by chemical synthesis, such as the sulfa drugs. Many antibiotics are relatively small molecules with a molecular weight less than 2000 Da. Unlike previous treatments for infections, which often consisted of administering chemical compounds such as strychnine and arsenic, with high toxicity also against mammals, antibiotics from microbes had no or few side effects and high effective target activity. Most anti-bacterial antibiotics do not have activity against viruses, fungi, or other microbes. Anti-bacterial antibiotics can be categorized based on their target specificity: "narrow-spectrum" antibiotics target particular types of bacteria, such as Gram-negative or Gram-positive bacteria, while broad-spectrum antibiotics affect a wide range of bacteria. The effectiveness of individual antibiotics varies with the location of the infection, the ability of the antibiotic to reach the site of infection, and the ability of the microbe to inactivate or excrete the antibiotic. Some anti-bacterial antibiotics destroy bacteria (bactericidal), whereas others prevent bacteria from multiplying (bacteriostatic). Oral antibiotics are simply ingested, while intravenous antibiotics are used in more serious cases, such as deep-seated systemic infections. Antibiotics may also sometimes be administered topically, as with eye drops or ointments. In the last few years, three new classes of antibiotics have been brought into clinical use. This follows a 40-year hiatus in discovering new classes of antibiotic compounds. These new antibiotics are of the following three classes: cyclic lipopeptides (daptomycin), glycylcyclines (tigecycline), and oxazolidinones (linezolid). Tigecycline is a broad-spectrum antibiotic, while the two others are used for gram-positive infections. These developments show promise as a means to counteract the growing bacterial resistance to existing antibiotics. Answered by Eboni Tortu 6 months ago.

A church is where we meet every Meetinghouse is where we meet on Sundays. We also hold midweek meetings for the Youth and women's Relief Society. Funerals and wedding receptions and some weddings are also held in the meeting houses. The regular meeting houses have the bishops offices. Usually 3-4 wards meet in each buildings, sometimes less. A stake covers like 10 Wards, the Stake center, houses regular wards, but is also where the office of the Stake President is located. The stake center has the baptismal font and the building are usually a little bit larger than a normal Meeting house. When we meet together as a stake for various reasons, the stake center is where we meet. Broadcasts from church leadership like the Annual Women's conference and General conference are shown at the stake Centers. In addition the stake center has all the functions of a regular meetinghouse. A temple is where some very sacred ordinances occur. Weddings/sealings occur at the temple. This is the only place where a marriage can be sealed for time and all eternity (forever). IN the US most LDS weddings occur in the temples. It is not required to marry in the temple, but most do so that the marriage can last forever. IN other countries where Temple marriages are not legally recognized the marriage is performed at the church building and then is sealed in the temple at a later time. There are other sacred ordinances performed in the temple such as the endowment. Regular worship services are not held at the temples. Anybody can go into a regular meetinghouse or stake center. Only worthy LDS members with a temple recommend can enter the temple. Maybe that was too much information, but I hope it answers your question. Answered by Odell Claborn 6 months ago.

Is the antibiotic Colistin a broad spectrum or narrow?
I can not seem to figure out if these antibiotics are narrow or broad spectrum..colistin, Neomycin, Gentamicin, Azithromycin, Trimethoprim, Naldixic acid, Chloramphenicol, Isoniazid, Ethambutol, Rifampin, Streptomycinthanks..could you also explain why each of these are broad/narrow/medium?? if not thats... Asked by Renate Sporysz 6 months ago.

I can not seem to figure out if these antibiotics are narrow or broad spectrum.. colistin, Neomycin, Gentamicin, Azithromycin, Trimethoprim, Naldixic acid, Chloramphenicol, Isoniazid, Ethambutol, Rifampin, Streptomycin thanks..could you also explain why each of these are broad/narrow/medium?? if not thats cool..at least have these as examples of what they are will help out a ton thanks!! Answered by Lionel Rapoza 6 months ago.

Good antibiotic stewardship practices include using a narrow spectrum antibiotic whenever possible. This is especially true when one has either 1. positive culture results to target treatment (assuming not a multi-drug resistant bug) or 2. high index of suspicion of what bug and that bug not multi-drug resistant. Penicillin is generally considered narrow spectrum in the US. Broad spectrum ABX are used when clinician has no idea yet about what bug and believes either a gram positive or gram negative organism could be responsible or a multi-drug resistant one. Use of broad spectrum ABX are associated with inducement of resistance not only of target bug, but others. I will not go into mechanisms of resistance here. Suffice it to say that MRSA, MRSE, multidrug resistant Klebsiella and VRE are only some of the bad strains of bacteria thought d/t overuse of broad spectrum ABX such as levofloxacin. Also note that the broader the spectrum of the ABX used, the more likelihood of overgrowth of yeast &/or Clostridia, thus more side effects like vaginitis, bloody diarrhea, etc. such as with Augmentin and later generation cephalosporins. Answered by Crystal Beile 6 months ago.

Is there any physician or clinical pharmacist to suggest right drugs for the case below:?
which antibiotic is suitable for prophylaxis of pancytopenia induced infections? Asked by Lue Phuong 6 months ago.

25 years, obese male presented to the emergency room after a sudden change in the mental status he was previously well but history of hypertention, in emergency room he show respiratory distress and increase in oxygen demand. Previously he was afebrile(36.8c), B.P:120/60 respiratory rate of 18 breaths/min and 89%oxygen saturation after nasal canolaton-98%. After physical examination .Left bronchi: Inflamation-rhonchi. Assisments: chest x-ray right mid zone and left mid zone show bilateral pneumonia ECG findings - sinus tachycardia rectal body temprature - 41c. Tachypanic (High respiration) 40 breaths/min b.p-60/40 Prescribe any antibiotic-? blood test: W.B.C count-17,000/dl HB level-15.39/dl Pletlet count-129000 Differential count-28%N 48%L Chemistry: Glucose-137/dl Creatinine level-3.1mg/dl PO2=53m/hg Bicarbonates-15mg/dl MRSA-Methecilin resistance staphylococcus aureus If during this period "pancytopenia" occur i.e,All blood cell count decreases. What is the complication in your opinion? if the antibiotic sugested was vancomycin...should we continue it or replace it?after having pancytopenia Answered by Mireya Goodrich 6 months ago.

If he was previously well x hypertension, his current main problem is the bilat pneumonia. it's probably viral pneumonia and not bacterial pneumonia so no antibiotics, treat his symptoms in the ER and have him follow up with his doc in a few days. Not sure what you mean with the MRSA line, are you suggesting he has MRSA? Vancomycin and teicoplanin are glycopeptide antibiotics used to treat MRSA infections but several newly discovered strains of MRSA show antibiotic resistance even to vancomycin and teicoplanin. These new evolutions of the MRSA bacterium have been dubbed Vancomycin intermediate-resistant Staphylococcus aureus (VISA). Linezolid, quinupristin/dalfopristin, daptomycin, and tigecycline are used to treat more severe infections that do not respond to glycopeptides such as vancomycin. Good question Answered by Minh Roofe 6 months ago.

What is the difference between penicillin and amoxicillin?
Asked by Sol Obriant 6 months ago.

Often in the development of drugs a naturally occurring substance (penicillin) will be "built on." So amoxicillin (and some other penicillins) are semi-synthetic, meaning that they are made from the naturally occurring drug penicillin and have the same "molecular base". All drugs in the class are penicillins like ampicillin and amoxicillin. Typically the semi-synthetic's are better in some ways then the natural drugs. So penicillin is only good against gram-positive organisms yet amoxicillin is also effective against some gram-negative organisms. And this is not unique to the penicillins. Tetracyclines are another major class of antibiotics. Tetracycline and a few other related drugs are naturally occurring. But newer semi-synthetics like doxycycline and minocycline even the recently made tigecycline are typically preferred over tetracycline. This happens to all sorts of drugs. Morphine is naturally occurring but many new and more potent semi-synthetics have been created like heroin, oxymorphone, and hydromorphone. Answered by Blanca Poska 6 months ago.

A number of published studies have shown that the MICs of amoxycillin and/or co-amoxyclav are lower than those of ampicillin and/or penicillin for Streptococcus pneumoniae. Other published studies have concluded that the activities of amoxycillin and co-amoxyclav are comparable with that of penicillin for S. pneumoniae. A collection of 5252 S. pneumoniae isolates obtained during a 5 year period (1992- 1996) was analysed to determine differences between the MICs of penicillin, amoxycillin and co-amoxyclav. Among the isolates analysed, 3788 (72%) were penicillin-susceptible, 615 (12%) were penicillin-intermediate and 849 (16%) were penicillin-resistant. Differences between the agents were assessed by examination of MIC distribution functions and simultaneous 95% CIs. In addition, penicillin-intermediate and -resistant isolates were analysed to determine the number and percentage of isolates which had an amoxycillin and co-amoxyclav MIC less than, equal to, or greater than the penicillin MIC. Results showed that the amoxycillin and co-amoxyclav MIC 90s were one two-fold dilution lower than those of penicillin for all isolates collected between 1992- 1993 and 1994- 1996. Simultaneous 95% CIs showed that the mean differences between MICs of amoxycillin and penicillin, and between MICs of co-amoxyclav and penicillin, were less than zero. The majority of the penicillin-intermediate and penicillin-resistant isolates had an amoxycillin and co-amoxyclav MIC less than the penicillin MIC. Answered by Kitty Win 6 months ago.

Are you looking for a chemical difference or a pharmacological one? Answered by Lawanna Plumer 6 months ago.

What is treatment for Staff infection?
I never had "Staff " until 2 years ago,now about every 2 months;It looks like a "Boil " but nothing comes out; Asked by Felicidad Dedic 6 months ago.

Depends heavily on the specific strain of Staph. Some are more resistant than others, but if you're talking about MRSA then our options are more narrowed, especially if we're hoping to use oral medication. For community-acquired MRSA, we can often get away with Bactrim (sulfamethoxazole/trimethoprim) or one of the tetracyclines (e.g. doxycycline, minocycline) or clindamycin, and of course linezolid. Intravenous options include vancomycin, daptomycin, linezolid, quinupristin-dalfopristin, or tigecycline. In any case, you need to see a physician for an appropriate diagnosis and recommendation. Answered by Haydee Ditmore 6 months ago.

I knew a man who has now passed hopefully into rest! who saved a mans leg from definite Amputation at the shock of a local Doctor who said it was impossible in agreement with the experts in hospital ( a university training hospital! ) he apparently had a necrotising staph infection that started just above the ankle and spread to the foot and just beneath the knee it hurt it stank and it oozed slime. It would probably have come under the heading of Leprosy in Old testament days, My elder friend had learned from another man who was in WW1 of a cure of such wicked infections apparently gleaned from a very old book and it was this:- (not very nice) having first prepared two ideal sized vessels and towels- Steep the offending part into a vessel of iced painfully cold water and hold it there until it becomes unbearable but do not remove it even to the point of torture! at this point remove and steep in the vessel also prepared beforehand with exceedingly hot water such that the hand cannot bear this same vessel having an ample helping of common salt stired in this too must be endured as a fierce fight and may need the helping hand of the butcher and baker whom you have not paid in full "they would gladly make you well enough for their means" whilst your wife prepares meat with a crust having supplied spirits of grain for your soul in the fight, this torturous regime need be repeated in turn as many times as can be on this day and then repeated the next, and all things be kept clean that come near the part!!!. OOOOOWCH! I believe that the mans wound was cleaned with old fashioned Carbolic soap thereafter and I have seen the result of such a procedure and it was amazing and apparently the old chap did scream like a Baby!. Good luck. Answered by Felica Jacques 6 months ago.


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