Application Information

This drug has been submitted to the FDA under the reference 009149/002.

Names and composition

"THORAZINE" is the commercial name of a drug composed of CHLORPROMAZINE HYDROCHLORIDE.

Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
009149/002 THORAZINE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 10MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
009149/007 THORAZINE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 25MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
009149/011 THORAZINE CHLORPROMAZINE HYDROCHLORIDE INJECTABLE/INJECTION 25MG per ML **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
009149/013 THORAZINE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 50MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
009149/018 THORAZINE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 100MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
009149/020 THORAZINE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 200MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
009149/022 THORAZINE CHLORPROMAZINE HYDROCHLORIDE SYRUP/ORAL 10MG per 5ML **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
009149/024 THORAZINE CHLORPROMAZINE SUPPOSITORY/RECTAL 25MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
009149/032 THORAZINE CHLORPROMAZINE HYDROCHLORIDE CONCENTRATE/ORAL 30MG per ML **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
009149/033 THORAZINE CHLORPROMAZINE SUPPOSITORY/RECTAL 100MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
009149/043 THORAZINE CHLORPROMAZINE HYDROCHLORIDE CONCENTRATE/ORAL 100MG per ML **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
011120/016 THORAZINE CHLORPROMAZINE HYDROCHLORIDE CAPSULE, EXTENDED RELEASE/ORAL 30MG
011120/017 THORAZINE CHLORPROMAZINE HYDROCHLORIDE CAPSULE, EXTENDED RELEASE/ORAL 75MG
011120/018 THORAZINE CHLORPROMAZINE HYDROCHLORIDE CAPSULE, EXTENDED RELEASE/ORAL 150MG
011120/019 THORAZINE CHLORPROMAZINE HYDROCHLORIDE CAPSULE, EXTENDED RELEASE/ORAL 200MG
011120/020 THORAZINE CHLORPROMAZINE HYDROCHLORIDE CAPSULE, EXTENDED RELEASE/ORAL 300MG

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
009149/002 THORAZINE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 10MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
009149/007 THORAZINE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 25MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
009149/011 THORAZINE CHLORPROMAZINE HYDROCHLORIDE INJECTABLE/INJECTION 25MG per ML **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
009149/013 THORAZINE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 50MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
009149/018 THORAZINE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 100MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
009149/020 THORAZINE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 200MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
009149/022 THORAZINE CHLORPROMAZINE HYDROCHLORIDE SYRUP/ORAL 10MG per 5ML **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
009149/032 THORAZINE CHLORPROMAZINE HYDROCHLORIDE CONCENTRATE/ORAL 30MG per ML **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
009149/043 THORAZINE CHLORPROMAZINE HYDROCHLORIDE CONCENTRATE/ORAL 100MG per ML **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
011120/016 THORAZINE CHLORPROMAZINE HYDROCHLORIDE CAPSULE, EXTENDED RELEASE/ORAL 30MG
011120/017 THORAZINE CHLORPROMAZINE HYDROCHLORIDE CAPSULE, EXTENDED RELEASE/ORAL 75MG
011120/018 THORAZINE CHLORPROMAZINE HYDROCHLORIDE CAPSULE, EXTENDED RELEASE/ORAL 150MG
011120/019 THORAZINE CHLORPROMAZINE HYDROCHLORIDE CAPSULE, EXTENDED RELEASE/ORAL 200MG
011120/020 THORAZINE CHLORPROMAZINE HYDROCHLORIDE CAPSULE, EXTENDED RELEASE/ORAL 300MG
040224/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE CONCENTRATE/ORAL 100MG per ML
040231/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE CONCENTRATE/ORAL 30MG per ML
080340/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 25MG
080340/002 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 50MG
080340/003 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 200MG
080365/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE INJECTABLE/INJECTION 25MG per ML
080370/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE INJECTABLE/INJECTION 25MG per ML
080403/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 25MG
080403/002 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 50MG
080403/003 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 100MG
080403/004 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 10MG
080403/005 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 200MG
080439/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 10MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
080439/002 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 25MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
080439/003 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 50MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
080439/004 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 100MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
080439/005 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 200MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
080983/004 SONAZINE CHLORPROMAZINE HYDROCHLORIDE CONCENTRATE/ORAL 30MG per ML
080983/005 SONAZINE CHLORPROMAZINE HYDROCHLORIDE CONCENTRATE/ORAL 100MG per ML
083040/001 SONAZINE CHLORPROMAZINE HYDROCHLORIDE SYRUP/ORAL 10MG per 5ML
083329/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE INJECTABLE/INJECTION 25MG per ML
083386/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 10MG
083549/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 10MG
083549/002 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 25MG
083549/003 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 50MG
083574/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 100MG
083575/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 200MG
084112/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 25MG
084113/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 50MG
084114/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 100MG
084115/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 200MG
084411/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 50MG
084412/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 100MG
084413/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 200MG
084414/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 10MG
084415/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 25MG
084423/001 PROMAPAR CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 25MG
084789/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 100MG
084800/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 50MG
084801/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 25MG
084802/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 200MG
084803/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 10MG
084911/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE INJECTABLE/INJECTION 25MG per ML
085331/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 10MG
085331/002 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 25MG
085331/003 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 50MG
085331/004 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 100MG
085331/005 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 200MG
085484/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 50MG
085591/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE INJECTABLE/INJECTION 25MG per ML
085748/002 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 200MG
085750/002 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 10MG
085751/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 25MG
085752/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 100MG
085956/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 25MG
085957/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 100MG
085958/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 200MG
085959/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 10MG
085960/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 50MG
086712/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE SYRUP/ORAL 10MG per 5ML
086863/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE CONCENTRATE/ORAL 100MG per ML
086885/001 PROMAPAR CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 200MG
086886/001 PROMAPAR CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 10MG
086887/001 PROMAPAR CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 50MG
086888/001 PROMAPAR CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 100MG
087032/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE CONCENTRATE/ORAL 30MG per ML
087053/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE CONCENTRATE/ORAL 100MG per ML
087645/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 25MG
087646/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 50MG
087783/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 10MG
087865/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 25MG
087878/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 50MG
087880/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 200MG
087884/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 100MG
088038/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE TABLET/ORAL 10MG
088157/001 CHLORPROMAZINE HYDROCHLORIDE INTENSOL CHLORPROMAZINE HYDROCHLORIDE CONCENTRATE/ORAL 30MG per ML
088158/001 CHLORPROMAZINE HYDROCHLORIDE INTENSOL CHLORPROMAZINE HYDROCHLORIDE CONCENTRATE/ORAL 100MG per ML
089563/001 CHLORPROMAZINE HYDROCHLORIDE CHLORPROMAZINE HYDROCHLORIDE INJECTABLE/INJECTION 25MG per ML

Ask a doctor

A licensed doctor will try to answer your question for free as quickly as possible. Free of charge during the beta period.

Answered questions

Mrs S. has been taking Thorazine for about 1 year?
She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the... Asked by Imogene Ngin 2 years ago.

She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the nursing diagnosis for this patient. a) What interventions would be used for this diagnosis? b) How would the nurse evaluate the outcome of the interventions? Answered by Maxwell Poulisse 2 years ago.

thorazine is bound to have more severe side effects.. clozaril is an atypical antipsychotic drug, so it will be LESS likely to cause tardive dyskenesia and akathisia and other similarly devastating side effects (thanks to its anticholinergic properties). However, there is recent evidence that such drugs may increase the likelihood of metabolic disturbances (leading to diabetes) and cardiovascular disease. There are also sexual functioning side effects, but that is common to many psychotropic meds...Note that slow titration of dosing of Clozaril significantly decreases the likelihood of orthostatic hypotension, so the switch is right on the money for this mrs. s....... I would say the switch from thorazine to clozaril is not a bad idea. I have no idea what you mean by "knowledge deficit" and "nursing diagnosis", I'm coming from a clinical psych perspective, but hope this helps! Answered by Brianna Kuck 2 years ago.


What is thorazine used for?
Asked by Lavonda Dyals 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Prince Pacius 2 years ago.

Thorazine Uses Answered by Arturo Palazola 2 years ago.

I don't know all of its uses, but I was given Thorazine for migraines. Answered by Charolette Kolis 2 years ago.

It is a old anti-psychotic. They use to use it a lot in psychiatric hospitals to calm down patients. It is also used for migraines at times. Answered by Val Lyden 2 years ago.

To mess with kids minds! Answered by Tyler Narcisse 2 years ago.

PAIN!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!... Answered by Janella Giardini 2 years ago.

Chlorpromazine was the first antipsychotic drug, used during the 1950s and 1960s. Used as chlorpromazine hydrochloride and sold under the tradenames Largactil® and Thorazine®, it has sedative, hypotensive and antiemetic properties as well as anticholinergic and antidopaminergic effects. It has also anxiolytic (alleviation of anxiety) properties. Today, chlorpromazine is considered a typical antipsychotic. Chlorpromazine acts as an antagonist (blocking agent) on different postsynaptic receptors: on dopaminergic-receptors (subtypes D1, D2, D3 and D4, different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), on alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism—controversial), and on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side effects). Additionally, chlorpromazine is a weak presynaptic inhibitor of dopamine reuptake, which may lead to (mild) antidepressive and antiparkinsonian effects. This action could also account for psychomotor agitation and amplification of psychosis (very rarely noted in clinical use). [edit] Peripheral Antagonist to H1 receptors (antiallergic effects), H2 receptors (reduction of forming of gastric juice), M1/M2-receptors (dry mouth, reduction in forming of gastric juice) and some 5-HT receptors (different anti-allergic/gastrointestinal actions). Because it acts on so many receptors, chlorpromazine is often referred to as "dirty drug", whereas the atypical neuroleptic amisulpride for example acts only on central D2/D3-receptors and is therefore a "clean drug". This distinction is not a positive or negative value judgment on the drug, rather it is a neutral term which merely describes the agent's relative pharmacology. [edit] History The drug had been developed by Laboratoires Rhône-Poulenc in 1950 but they sold the rights in 1952 to Smith-Kline & French (today's GlaxoSmithKline). The drug was being sold as an antiemetic when its other use was noted. Smith-Kline was quick to encourage clinical trials and in 1954 the drug was approved in the US for psychiatric treatment. Over 100 million people were treated but the popularity of the drug fell from the late 1960s as the severe extrapyramidal side effects and tardive dyskinesia became more of a concern. From chlorpromazine a number of other similar neuroleptics were developed (e.g. triflupromazine, trifluoperazine). Previously used as an antihistamine and antiemetic its effects on mental state were first reported by the French doctor Henri Laborit in 1951 or 1952 (different sources) as sedation without narcosis. It became possible to cause 'artificial hibernation' in patients, if used as a cocktail together with pethidine and hydergine. Patients with shock, severe trauma or burns, become, if treated so, sedated, without anxiety and unreponsive/indifferent to painful external stimuli like minor surgical interventions. It was first used for psychiatric patients by Pierre Deniker and Jean Delay in 1953. Drug treatment with chlorpromazine went beyond simple sedation with patients showing improvements in thinking and emotional behaviour. Ironically, the antipsychotic properties of chlorpromazine appear to be unrelated to its sedative properties. During long term therapy some tolerance to the sedation effect develops. Chlorpromazine substituted and eclipsed the old therapies of electro- and insulin shocks and other methods such as psychosurgical means (lobotomy) causing permanent brain injury. Chlorpromazine has given approximately 70% of all schizophrenic patients a complete remission or near so and a normal, gainful human life. Before the era of neuroleptics, starting with chlorpromazine, positive long-term results for psychotic patients were only 20%. [edit] Side effects Side effects of chlorpromazine are typical of early generation neuroleptics. They include extrapyramidal side effects such as tardive dyskinesia and akathisia. A particularly severe side effect is the neuroleptic malignant syndrome which occurs in approximately 0.05% and can be fatal. Also, chlorpromazine may lower seizure threshold. Additional side effects include dry mouth, increased appetite with weight gain, constipation and urinary retention. Glucose tolerance may be impaired. An allergic skin rash and photosensitivity may occur. Other important and severe side effects are a strong reduction in the number of white blood cells, referred to as leukopenia, or, in extreme cases, even agranulocytosis may result, which may lead to death via uncontrollable infections and/or sepsis. Chlorpromazine is the neuroleptic drug with the highest rates (0.5% to 1%) of liver toxicity of the cholestatic type. The sedation effect combined with indifference to physical stimuli, anecdotally known as the "thorazine shuffle," has long been associated with the drug. The image of psychiatric patients staggering mute around a padded cell has earned those particular side effects a place in mainstream pop culture. [edit] Interactions Chlorpromazine intensifies the central depressive action of drugs with such activity (tranquilizers, barbiturates, narcotics, antihistamines, OTC-antiemetics etc.). A dose reduction of chlorpromazine or the other drug may be necessary. Chlorpromazine also intensifies the actions and undesired side effects of antihypertensive medications and anticholinergic drugs. The combination of chlorpromazine with other antipsychotics may result in increased central depression, hypotension and extrapyramidal side effects, but may sometimes enhance the clinical results of therapy. The anti-worm drug (antihelminthic) piperazine may intensify extrapyramidal side effects. In general, all neuroleptics may lead to seizures in combination with tramadol (Ultram). Chlorpromazine may increase the insulin needs of diabetic patients. Drugs like SSRIs, St. John's Wort and barbiturates can inhibit various CYP-isoenzymes such as CYP2D6, needed for metabolization of chlorpromazine and/or its metabolites. Theoretically, this should increase the half-lives of chlorpromazine and possibly its metabolites, dosing changes necessary. The exact clinical significance of this enzyme induction and its therapeutic consequences are unknown at present time and remain to be evaluated. [edit] Uses [edit] Common uses [edit] As an antipsychotic The use of chlorpromazine has been primarily replaced by newer generation of atypical antipsychotics which have an improved side effect profile. Chlorpromazine is classified as a low- to moderate-potency antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of manic depression as well as amphetamine-induced psychoses. Chlorpromazine formerly was the drug of choice to treat LSD (and other psychedelic/hallucinogen) intoxication in a hospital setting, resulting in it gaining an erroneous reputation as the LSD "antidote". Now haloperidol is more commonly used in such situations. [edit] Other uses It has also been used in porphyria, as part of tetanus treatment and for behavioral problems in children. It still is well recommended for short term management of severe anxiety and aggressive episodes. Resistant and severe hiccups, severe nausea/emesis and preanesthetic conditioning have been other indications in the past. It can be used to treat amphetamine overdose. [1] [edit] Off-label and controversial uses Chlorpromazine is occasionally used off-label for treatment of severe migraine. Sometimes it is used in small doses to improve nausea/emesis opioid-treated cancer patients encounter and to intensify and prolong the analgesic action of the opioids given. Interestingly, it remains controversial whether or not chlorpromazine has its own analgesic properties. Analgesic properties may result from a central action on the hypothalamus; the patient may feel the pain much less than before. Other mechanisms may be an interaction with opioid receptors centrally and/or in the spinal cord. Some experts on the contrary say that chlorpromazine, like other phenothiazines, may even have antianalgesic properties. Chlorpromazine has been proposed as useful in newborns for the treatment of opioid withdrawal, if the mother was opioid-dependent. The latter indication remains highly controversial. Chlorpromazine, as well as other neuroleptics, may also be used to alleviate the symptoms of alcohol withdrawal (chlorpromazine may lower the seizure-threshold in alcoholics). It has a unique action in cholera, reducing the loss of water by approximately 30%. In Germany, the brand of chlorpromazine drug Propaphenin® has additional indications for insomnia and itching skin disease. [edit] Veterinary uses Chlorpromazine is primarily used as an antiemetic in dogs and cats. It is also sometimes used as a preanesthetic and muscle relaxant in cattle, swine, sheep, and goats. It is generally contraindicated for use with horses, due to a high incidence of ataxia and altered mentation. [edit] Dosage In any case, use is determined by an attending physician. The following information is intended to serve as a guideline: A wide range is covered from 25 mg oral or intramuscular for mild sedation, every 8 hours, up to 100 mg every 6 hours for severely disturbed patients. Different qualified sources give 800 mg/day to 1,200 mg/day as highest dose. At least there is one small clinical trial in treatment-resistant patients with a daily dose of 1,200 mg chlorpromazine (and 4 mg Benztropine to counteract early extrapyramidal side effects, which were anticipated with this unusual high chlorpromazine dose). Initial doses should be low and be increased gradually. It is recommended that most of the daily dose (e.g. 2/3) is given at bedtime for maximum hypnotic activity and minimal daytime sedation and hypotension. In the USA there are controlled release forms of Thorazine (e.g. 300 mg). After the individual dose is well established, such a CR capsule can be given with the evening meal as a single dose, covering the next 24 hours. The lowest dosage compatible with good therapeutic effect should be given. Dosage in ambulatory patients should be particularly low (minimizing sedation and hypotension). The direct i.v.-injection of undiluted solution is contraindicated (massive fall in blood pressure, cardiovascular collapse), for i.v.-infusion of dilutions the (hospitalized) patient should be lying and the infusion rate should be as slow as possible. Afterwards the patient should rest in the lying position for at least 30 minutes. [edit] Necessary examinations and laboratory checks during treatment All patients treated with chlorpromazine on a long-term-basis should have regularly checked their blood-pressure, pulse rate, laboratory-tests (liver function tests, kidney-values, blood cell counts including differenciated white blood counts, counts of red blood cells and thrombocytes), ECG and EEG. The frequency of all checks should be determined for the individual patient and may be done in shorter intervals during the first 3 months of treatment and less often afterwards. Some side effects seem to appear more frequently during the first months of therapy (sedation, hypotension, liver damage) while others do not (e.g. tardive dyskinesia). [edit] Discontinuation of treatment Also, in regular intervals the treating physician should evaluate whether continued treatment is needed. If not, the drug should never be stopped suddenly, due to very unpleasant 'withdrawal-symptoms', such as agitation, sleeplessness, states of anxiety, etc. However, these symptoms definitely do not indicate psychological or physical dependence. The dose should rather be slowly tapered down at a rate of approximately 20–25% per week or even slower to avoid the aforementioned bothersome symptoms. Chlorpromazine is derived from phenothiazine, and has an aliphatic side chain, typical for low to middle potency neuroleptics. The oral bioavailability is estimated to be 30–50% due to extensive first pass metabolization in the liver. Its elimination-halflife is 16–30 hours. It has many active metabolites (approx. 75 different ones) with greatly varying halflives and own pharmacological profiles. The CYP-450 isoenzymes 1A2 and 2D6 are needed for metabolization of chlorpromazine and the subtype 2D6 is inhibited by chlorpromazine (NB: possible interactions with other drugs). Answered by Chante Mcredmond 2 years ago.


What are some reasons why a person might be prescribed 200 mg of thorazine?
...from a medical prospective. Asked by Dierdre Mcconney 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Ja Guitierrez 2 years ago.

The warding off man or woman will have angry through a comment the have shyed away from man or woman made. The warding off man or woman will have a few prejudice towards the have shyed away from man or woman. The have shyed away from man or woman might remind the warding off man or woman of an ex-boyfriend or ex-female friend or different man or woman who the warding off man or woman desires to omit. Maybe anybody instructed the warding off man or woman that the have shyed away from man or woman does not like him/her. But the object is, why do you care? Answered by Tamiko Rockers 2 years ago.

It's an anti-psychotic, for bipolar disorder or schizophrenia. Answered by Marin Lehrfeld 2 years ago.


What is Thorazine, Lorazepam and Compazine? What are they used for?
Asked by Lou Moxness 2 years ago.

Chlorpromazine is classified as a low-potency typical antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of bipolar disorder, as well as amphetamine-induced psychoses. Low-potency antipsychotics have more anticholinergic side effects, such as dry mouth, sedation, and constipation, and lower rates of extrapyramidal side effects, while high-potency antipsychotics (such as haloperidol) have the reverse profile. Chlorpromazine has also been used in porphyria and as part of tetanus treatment. It still is recommended for short-term management of severe anxiety and psychotic aggression. Resistant and severe hiccups, severe nausea/emesis, and preanesthetic conditioning are other uses. Symptoms of delirium in medically-hospitalized AIDS patients have been effectively treated with low doses of chlorpromazine Answered by Jacqui Rease 2 years ago.

They are antipsycotic drugs used to treat manic depression, schizophrenia Answered by Ashli Pavlovich 2 years ago.


Is 25 mg of Thorazine safe to take for anxiety?
Asked by Matilde Pequeno 2 years ago.

Thorazine, at 25 mg, is used for chronic hiccups, nausea and vomitting, sedation before surgery, and sometimes anxiety. However, it is anti-psychotic, a tranquilizer, and very old school, so if it was not prescribed to you, don't tske it. This may just be a question of general curiosity, but if you need meds for anxiety, there are more suitable ones than thorazine. See the doc. to get the right one for you! Answered by Maude Ball 2 years ago.

Thorazine is not an anti-anxiety drug. It is an antipsychotic drug. Please do not take ANY prescription medication unless under the direction of your personal physician. Answered by Lennie Cuddington 2 years ago.

I think I would speak to a Pharmacist before listening to someone on Yahoo answers. Answered by Marshall Revermann 2 years ago.

The potential for causing chronic movement disorders makes it far from ideal. Answered by Jill Caver 2 years ago.

It has more potential side effects than newer drugs. For example, seizures, heat exhaustion, drowsiness. Answered by Odis Baranski 2 years ago.


Is it true that Thorazine is as dangerous and the Psychiatric critics say it is?
From Psychiatric critics they criticize Thorazine a lot and say it messes people up like Lobotomy. Here is an example website criticizing Thorazine: http://www.sntp.net/drugs/thorazine.htm Asked by Doris Hollon 2 years ago.

Thorazine is no more dangerous than the others. Staying on it for too long can lead to specific complications, which is true with other anti-psychotics. It isn't used as much these days, but it is still a consideration for some people. It's OK to critisize thorazine, but no more so than for other such drugs. Answered by Doreen Vanderkam 2 years ago.

Wow! Normally, I don't answer questions that want to learn more and more detail. As in your case, because they require a long process, and it is the risk of not solve all of yours problems. I would suggest to proceed analytically with the help of keywords to be included in Yahoo! From what you climb, narrowing the field with new keywords, until you will be fully satisfied. good luck! Answered by Kirsten Golar 2 years ago.


Is Thorazine(Chlorpromazine) an older anti-psychotic?
I was prescribed this recently for Bipolar Disorder. Is it an older anti-psychotic?Thanks Asked by Jocelyn Okorududu 2 years ago.

Thorazine was one of the first anti-psychotics, created in 1950. It is still occasionally used in the treatment of schizophrenia and bipolar disorder, but not as often as it was a few decades ago. It's a low potency anti-psychotic, so there is a lower chance of experiencing unwanted side effects. Answered by Larae Zotos 2 years ago.


How long will thorazine take to get in my urine stream?
i want to take a thorazine but i have a drug test at 10:00am and dont know what time yo take it so i can pass the drug test and still take it tonight Asked by Madelene Galuski 2 years ago.

To my understanding, Thorazine is an anti-psychotic medication. It's not typically screened for on a drug test. However, if you do register with a false positive in another drug category as a result of this medication, all you have to do is show proof of a prescription and you're in the clear. Thorazine is excreted primarily through the urine and has a half-life from 10 to 40 hours. Answered by Mollie Denkins 2 years ago.

You can't wait until after the test to take it - just to be on the safe side? Answered by Lady Strength 2 years ago.


About Thorazine/Largactil?
I have read alot about this drug, but I would like to hear from somone that has actually used it, or someone who knows someone who has used it.How sedating/tranquilizing is it? What are the main side-effects, and what pills do I need to counteract these side-effects? Asked by Eladia Raboin 2 years ago.

About counteraction - I'm not sure. You'd have to take it to know if you'd have any counteractions, first. I took Thorazine for about a month for sleep. It never made me tired. It would, however, keep me asleep for 8-12 hrs once I laid down and fell asleep. Not a good drug if you need to be knocked out (in my opinion). I'm sure you've heard it called 'the chemical lobotomy'. I didn't feel like it erased too much of my personality, and I was still heavily addicted to drugs and it never made me seek/want drugs less. I really don't remember much from taking it. I snorted it once, and it burned like a SOB, but it knocked me out right away. Answered by Donita Kniffen 2 years ago.


Mrs S. has been taking Thorazine for about 1 year?
She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the... Asked by Ernesto Ekstrand 2 years ago.

She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the nursing diagnosis for this patient. a) What interventions would be used for this diagnosis? b) How would the nurse evaluate the outcome of the interventions? Answered by Jonnie Klee 2 years ago.

thorazine is bound to have more severe side effects.. clozaril is an atypical antipsychotic drug, so it will be LESS likely to cause tardive dyskenesia and akathisia and other similarly devastating side effects (thanks to its anticholinergic properties). However, there is recent evidence that such drugs may increase the likelihood of metabolic disturbances (leading to diabetes) and cardiovascular disease. There are also sexual functioning side effects, but that is common to many psychotropic meds...Note that slow titration of dosing of Clozaril significantly decreases the likelihood of orthostatic hypotension, so the switch is right on the money for this mrs. s....... I would say the switch from thorazine to clozaril is not a bad idea. I have no idea what you mean by "knowledge deficit" and "nursing diagnosis", I'm coming from a clinical psych perspective, but hope this helps! Answered by Georgetta Stocker 2 years ago.


What is thorazine used for?
Asked by Vanda Pharao 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Sarai Bonaccorso 2 years ago.

Thorazine Uses Answered by Carmelina Bruh 2 years ago.

I don't know all of its uses, but I was given Thorazine for migraines. Answered by Lashunda Ramy 2 years ago.

It is a old anti-psychotic. They use to use it a lot in psychiatric hospitals to calm down patients. It is also used for migraines at times. Answered by Melvin Shibi 2 years ago.

To mess with kids minds! Answered by Hassie Austgen 2 years ago.

PAIN!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!... Answered by Winfred Blankenbecler 2 years ago.

Chlorpromazine was the first antipsychotic drug, used during the 1950s and 1960s. Used as chlorpromazine hydrochloride and sold under the tradenames Largactil® and Thorazine®, it has sedative, hypotensive and antiemetic properties as well as anticholinergic and antidopaminergic effects. It has also anxiolytic (alleviation of anxiety) properties. Today, chlorpromazine is considered a typical antipsychotic. Chlorpromazine acts as an antagonist (blocking agent) on different postsynaptic receptors: on dopaminergic-receptors (subtypes D1, D2, D3 and D4, different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), on alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism—controversial), and on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side effects). Additionally, chlorpromazine is a weak presynaptic inhibitor of dopamine reuptake, which may lead to (mild) antidepressive and antiparkinsonian effects. This action could also account for psychomotor agitation and amplification of psychosis (very rarely noted in clinical use). [edit] Peripheral Antagonist to H1 receptors (antiallergic effects), H2 receptors (reduction of forming of gastric juice), M1/M2-receptors (dry mouth, reduction in forming of gastric juice) and some 5-HT receptors (different anti-allergic/gastrointestinal actions). Because it acts on so many receptors, chlorpromazine is often referred to as "dirty drug", whereas the atypical neuroleptic amisulpride for example acts only on central D2/D3-receptors and is therefore a "clean drug". This distinction is not a positive or negative value judgment on the drug, rather it is a neutral term which merely describes the agent's relative pharmacology. [edit] History The drug had been developed by Laboratoires Rhône-Poulenc in 1950 but they sold the rights in 1952 to Smith-Kline & French (today's GlaxoSmithKline). The drug was being sold as an antiemetic when its other use was noted. Smith-Kline was quick to encourage clinical trials and in 1954 the drug was approved in the US for psychiatric treatment. Over 100 million people were treated but the popularity of the drug fell from the late 1960s as the severe extrapyramidal side effects and tardive dyskinesia became more of a concern. From chlorpromazine a number of other similar neuroleptics were developed (e.g. triflupromazine, trifluoperazine). Previously used as an antihistamine and antiemetic its effects on mental state were first reported by the French doctor Henri Laborit in 1951 or 1952 (different sources) as sedation without narcosis. It became possible to cause 'artificial hibernation' in patients, if used as a cocktail together with pethidine and hydergine. Patients with shock, severe trauma or burns, become, if treated so, sedated, without anxiety and unreponsive/indifferent to painful external stimuli like minor surgical interventions. It was first used for psychiatric patients by Pierre Deniker and Jean Delay in 1953. Drug treatment with chlorpromazine went beyond simple sedation with patients showing improvements in thinking and emotional behaviour. Ironically, the antipsychotic properties of chlorpromazine appear to be unrelated to its sedative properties. During long term therapy some tolerance to the sedation effect develops. Chlorpromazine substituted and eclipsed the old therapies of electro- and insulin shocks and other methods such as psychosurgical means (lobotomy) causing permanent brain injury. Chlorpromazine has given approximately 70% of all schizophrenic patients a complete remission or near so and a normal, gainful human life. Before the era of neuroleptics, starting with chlorpromazine, positive long-term results for psychotic patients were only 20%. [edit] Side effects Side effects of chlorpromazine are typical of early generation neuroleptics. They include extrapyramidal side effects such as tardive dyskinesia and akathisia. A particularly severe side effect is the neuroleptic malignant syndrome which occurs in approximately 0.05% and can be fatal. Also, chlorpromazine may lower seizure threshold. Additional side effects include dry mouth, increased appetite with weight gain, constipation and urinary retention. Glucose tolerance may be impaired. An allergic skin rash and photosensitivity may occur. Other important and severe side effects are a strong reduction in the number of white blood cells, referred to as leukopenia, or, in extreme cases, even agranulocytosis may result, which may lead to death via uncontrollable infections and/or sepsis. Chlorpromazine is the neuroleptic drug with the highest rates (0.5% to 1%) of liver toxicity of the cholestatic type. The sedation effect combined with indifference to physical stimuli, anecdotally known as the "thorazine shuffle," has long been associated with the drug. The image of psychiatric patients staggering mute around a padded cell has earned those particular side effects a place in mainstream pop culture. [edit] Interactions Chlorpromazine intensifies the central depressive action of drugs with such activity (tranquilizers, barbiturates, narcotics, antihistamines, OTC-antiemetics etc.). A dose reduction of chlorpromazine or the other drug may be necessary. Chlorpromazine also intensifies the actions and undesired side effects of antihypertensive medications and anticholinergic drugs. The combination of chlorpromazine with other antipsychotics may result in increased central depression, hypotension and extrapyramidal side effects, but may sometimes enhance the clinical results of therapy. The anti-worm drug (antihelminthic) piperazine may intensify extrapyramidal side effects. In general, all neuroleptics may lead to seizures in combination with tramadol (Ultram). Chlorpromazine may increase the insulin needs of diabetic patients. Drugs like SSRIs, St. John's Wort and barbiturates can inhibit various CYP-isoenzymes such as CYP2D6, needed for metabolization of chlorpromazine and/or its metabolites. Theoretically, this should increase the half-lives of chlorpromazine and possibly its metabolites, dosing changes necessary. The exact clinical significance of this enzyme induction and its therapeutic consequences are unknown at present time and remain to be evaluated. [edit] Uses [edit] Common uses [edit] As an antipsychotic The use of chlorpromazine has been primarily replaced by newer generation of atypical antipsychotics which have an improved side effect profile. Chlorpromazine is classified as a low- to moderate-potency antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of manic depression as well as amphetamine-induced psychoses. Chlorpromazine formerly was the drug of choice to treat LSD (and other psychedelic/hallucinogen) intoxication in a hospital setting, resulting in it gaining an erroneous reputation as the LSD "antidote". Now haloperidol is more commonly used in such situations. [edit] Other uses It has also been used in porphyria, as part of tetanus treatment and for behavioral problems in children. It still is well recommended for short term management of severe anxiety and aggressive episodes. Resistant and severe hiccups, severe nausea/emesis and preanesthetic conditioning have been other indications in the past. It can be used to treat amphetamine overdose. [1] [edit] Off-label and controversial uses Chlorpromazine is occasionally used off-label for treatment of severe migraine. Sometimes it is used in small doses to improve nausea/emesis opioid-treated cancer patients encounter and to intensify and prolong the analgesic action of the opioids given. Interestingly, it remains controversial whether or not chlorpromazine has its own analgesic properties. Analgesic properties may result from a central action on the hypothalamus; the patient may feel the pain much less than before. Other mechanisms may be an interaction with opioid receptors centrally and/or in the spinal cord. Some experts on the contrary say that chlorpromazine, like other phenothiazines, may even have antianalgesic properties. Chlorpromazine has been proposed as useful in newborns for the treatment of opioid withdrawal, if the mother was opioid-dependent. The latter indication remains highly controversial. Chlorpromazine, as well as other neuroleptics, may also be used to alleviate the symptoms of alcohol withdrawal (chlorpromazine may lower the seizure-threshold in alcoholics). It has a unique action in cholera, reducing the loss of water by approximately 30%. In Germany, the brand of chlorpromazine drug Propaphenin® has additional indications for insomnia and itching skin disease. [edit] Veterinary uses Chlorpromazine is primarily used as an antiemetic in dogs and cats. It is also sometimes used as a preanesthetic and muscle relaxant in cattle, swine, sheep, and goats. It is generally contraindicated for use with horses, due to a high incidence of ataxia and altered mentation. [edit] Dosage In any case, use is determined by an attending physician. The following information is intended to serve as a guideline: A wide range is covered from 25 mg oral or intramuscular for mild sedation, every 8 hours, up to 100 mg every 6 hours for severely disturbed patients. Different qualified sources give 800 mg/day to 1,200 mg/day as highest dose. At least there is one small clinical trial in treatment-resistant patients with a daily dose of 1,200 mg chlorpromazine (and 4 mg Benztropine to counteract early extrapyramidal side effects, which were anticipated with this unusual high chlorpromazine dose). Initial doses should be low and be increased gradually. It is recommended that most of the daily dose (e.g. 2/3) is given at bedtime for maximum hypnotic activity and minimal daytime sedation and hypotension. In the USA there are controlled release forms of Thorazine (e.g. 300 mg). After the individual dose is well established, such a CR capsule can be given with the evening meal as a single dose, covering the next 24 hours. The lowest dosage compatible with good therapeutic effect should be given. Dosage in ambulatory patients should be particularly low (minimizing sedation and hypotension). The direct i.v.-injection of undiluted solution is contraindicated (massive fall in blood pressure, cardiovascular collapse), for i.v.-infusion of dilutions the (hospitalized) patient should be lying and the infusion rate should be as slow as possible. Afterwards the patient should rest in the lying position for at least 30 minutes. [edit] Necessary examinations and laboratory checks during treatment All patients treated with chlorpromazine on a long-term-basis should have regularly checked their blood-pressure, pulse rate, laboratory-tests (liver function tests, kidney-values, blood cell counts including differenciated white blood counts, counts of red blood cells and thrombocytes), ECG and EEG. The frequency of all checks should be determined for the individual patient and may be done in shorter intervals during the first 3 months of treatment and less often afterwards. Some side effects seem to appear more frequently during the first months of therapy (sedation, hypotension, liver damage) while others do not (e.g. tardive dyskinesia). [edit] Discontinuation of treatment Also, in regular intervals the treating physician should evaluate whether continued treatment is needed. If not, the drug should never be stopped suddenly, due to very unpleasant 'withdrawal-symptoms', such as agitation, sleeplessness, states of anxiety, etc. However, these symptoms definitely do not indicate psychological or physical dependence. The dose should rather be slowly tapered down at a rate of approximately 20–25% per week or even slower to avoid the aforementioned bothersome symptoms. Chlorpromazine is derived from phenothiazine, and has an aliphatic side chain, typical for low to middle potency neuroleptics. The oral bioavailability is estimated to be 30–50% due to extensive first pass metabolization in the liver. Its elimination-halflife is 16–30 hours. It has many active metabolites (approx. 75 different ones) with greatly varying halflives and own pharmacological profiles. The CYP-450 isoenzymes 1A2 and 2D6 are needed for metabolization of chlorpromazine and the subtype 2D6 is inhibited by chlorpromazine (NB: possible interactions with other drugs). Answered by Doreen Diogo 2 years ago.


What are some reasons why a person might be prescribed 200 mg of thorazine?
...from a medical prospective. Asked by Isaura Foecke 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Rosario Babjeck 2 years ago.

The warding off man or woman will have angry through a comment the have shyed away from man or woman made. The warding off man or woman will have a few prejudice towards the have shyed away from man or woman. The have shyed away from man or woman might remind the warding off man or woman of an ex-boyfriend or ex-female friend or different man or woman who the warding off man or woman desires to omit. Maybe anybody instructed the warding off man or woman that the have shyed away from man or woman does not like him/her. But the object is, why do you care? Answered by Kerry Goepel 2 years ago.

It's an anti-psychotic, for bipolar disorder or schizophrenia. Answered by Amy Clancey 2 years ago.


What is Thorazine, Lorazepam and Compazine? What are they used for?
Asked by Shaunda Swider 2 years ago.

Chlorpromazine is classified as a low-potency typical antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of bipolar disorder, as well as amphetamine-induced psychoses. Low-potency antipsychotics have more anticholinergic side effects, such as dry mouth, sedation, and constipation, and lower rates of extrapyramidal side effects, while high-potency antipsychotics (such as haloperidol) have the reverse profile. Chlorpromazine has also been used in porphyria and as part of tetanus treatment. It still is recommended for short-term management of severe anxiety and psychotic aggression. Resistant and severe hiccups, severe nausea/emesis, and preanesthetic conditioning are other uses. Symptoms of delirium in medically-hospitalized AIDS patients have been effectively treated with low doses of chlorpromazine Answered by Lyda Smallen 2 years ago.

They are antipsycotic drugs used to treat manic depression, schizophrenia Answered by Monika Latino 2 years ago.


Is 25 mg of Thorazine safe to take for anxiety?
Asked by Josie Hornak 2 years ago.

Thorazine, at 25 mg, is used for chronic hiccups, nausea and vomitting, sedation before surgery, and sometimes anxiety. However, it is anti-psychotic, a tranquilizer, and very old school, so if it was not prescribed to you, don't tske it. This may just be a question of general curiosity, but if you need meds for anxiety, there are more suitable ones than thorazine. See the doc. to get the right one for you! Answered by Rochell Sthilaire 2 years ago.

Thorazine is not an anti-anxiety drug. It is an antipsychotic drug. Please do not take ANY prescription medication unless under the direction of your personal physician. Answered by Bailey Brisco 2 years ago.

I think I would speak to a Pharmacist before listening to someone on Yahoo answers. Answered by Frankie Behunin 2 years ago.

The potential for causing chronic movement disorders makes it far from ideal. Answered by Annalisa Strada 2 years ago.

It has more potential side effects than newer drugs. For example, seizures, heat exhaustion, drowsiness. Answered by Marchelle Hargers 2 years ago.


Is it true that Thorazine is as dangerous and the Psychiatric critics say it is?
From Psychiatric critics they criticize Thorazine a lot and say it messes people up like Lobotomy. Here is an example website criticizing Thorazine: http://www.sntp.net/drugs/thorazine.htm Asked by Darron Brofman 2 years ago.

Thorazine is no more dangerous than the others. Staying on it for too long can lead to specific complications, which is true with other anti-psychotics. It isn't used as much these days, but it is still a consideration for some people. It's OK to critisize thorazine, but no more so than for other such drugs. Answered by Inez Sgueglia 2 years ago.

Wow! Normally, I don't answer questions that want to learn more and more detail. As in your case, because they require a long process, and it is the risk of not solve all of yours problems. I would suggest to proceed analytically with the help of keywords to be included in Yahoo! From what you climb, narrowing the field with new keywords, until you will be fully satisfied. good luck! Answered by Jerome Hummel 2 years ago.


Is Thorazine(Chlorpromazine) an older anti-psychotic?
I was prescribed this recently for Bipolar Disorder. Is it an older anti-psychotic?Thanks Asked by Jayson Rodick 2 years ago.

Thorazine was one of the first anti-psychotics, created in 1950. It is still occasionally used in the treatment of schizophrenia and bipolar disorder, but not as often as it was a few decades ago. It's a low potency anti-psychotic, so there is a lower chance of experiencing unwanted side effects. Answered by Rosanne Wenker 2 years ago.


How long will thorazine take to get in my urine stream?
i want to take a thorazine but i have a drug test at 10:00am and dont know what time yo take it so i can pass the drug test and still take it tonight Asked by My Decraene 2 years ago.

To my understanding, Thorazine is an anti-psychotic medication. It's not typically screened for on a drug test. However, if you do register with a false positive in another drug category as a result of this medication, all you have to do is show proof of a prescription and you're in the clear. Thorazine is excreted primarily through the urine and has a half-life from 10 to 40 hours. Answered by Carrie Skibbe 2 years ago.

You can't wait until after the test to take it - just to be on the safe side? Answered by Audry Chowdhury 2 years ago.


About Thorazine/Largactil?
I have read alot about this drug, but I would like to hear from somone that has actually used it, or someone who knows someone who has used it.How sedating/tranquilizing is it? What are the main side-effects, and what pills do I need to counteract these side-effects? Asked by Errol Grine 2 years ago.

About counteraction - I'm not sure. You'd have to take it to know if you'd have any counteractions, first. I took Thorazine for about a month for sleep. It never made me tired. It would, however, keep me asleep for 8-12 hrs once I laid down and fell asleep. Not a good drug if you need to be knocked out (in my opinion). I'm sure you've heard it called 'the chemical lobotomy'. I didn't feel like it erased too much of my personality, and I was still heavily addicted to drugs and it never made me seek/want drugs less. I really don't remember much from taking it. I snorted it once, and it burned like a SOB, but it knocked me out right away. Answered by Adaline Cappleman 2 years ago.


Mrs S. has been taking Thorazine for about 1 year?
She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the... Asked by Fidela Puidokas 2 years ago.

She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the nursing diagnosis for this patient. a) What interventions would be used for this diagnosis? b) How would the nurse evaluate the outcome of the interventions? Answered by Brande Chean 2 years ago.

thorazine is bound to have more severe side effects.. clozaril is an atypical antipsychotic drug, so it will be LESS likely to cause tardive dyskenesia and akathisia and other similarly devastating side effects (thanks to its anticholinergic properties). However, there is recent evidence that such drugs may increase the likelihood of metabolic disturbances (leading to diabetes) and cardiovascular disease. There are also sexual functioning side effects, but that is common to many psychotropic meds...Note that slow titration of dosing of Clozaril significantly decreases the likelihood of orthostatic hypotension, so the switch is right on the money for this mrs. s....... I would say the switch from thorazine to clozaril is not a bad idea. I have no idea what you mean by "knowledge deficit" and "nursing diagnosis", I'm coming from a clinical psych perspective, but hope this helps! Answered by Renna Mcglothlen 2 years ago.


What is thorazine used for?
Asked by Zula Cokins 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Walker Schech 2 years ago.

Thorazine Uses Answered by Michal Kuney 2 years ago.

I don't know all of its uses, but I was given Thorazine for migraines. Answered by Dorethea Stefanow 2 years ago.

It is a old anti-psychotic. They use to use it a lot in psychiatric hospitals to calm down patients. It is also used for migraines at times. Answered by Dagmar Dicocco 2 years ago.

To mess with kids minds! Answered by Leanna Ruffing 2 years ago.

PAIN!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!... Answered by Niki Russnak 2 years ago.

Chlorpromazine was the first antipsychotic drug, used during the 1950s and 1960s. Used as chlorpromazine hydrochloride and sold under the tradenames Largactil® and Thorazine®, it has sedative, hypotensive and antiemetic properties as well as anticholinergic and antidopaminergic effects. It has also anxiolytic (alleviation of anxiety) properties. Today, chlorpromazine is considered a typical antipsychotic. Chlorpromazine acts as an antagonist (blocking agent) on different postsynaptic receptors: on dopaminergic-receptors (subtypes D1, D2, D3 and D4, different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), on alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism—controversial), and on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side effects). Additionally, chlorpromazine is a weak presynaptic inhibitor of dopamine reuptake, which may lead to (mild) antidepressive and antiparkinsonian effects. This action could also account for psychomotor agitation and amplification of psychosis (very rarely noted in clinical use). [edit] Peripheral Antagonist to H1 receptors (antiallergic effects), H2 receptors (reduction of forming of gastric juice), M1/M2-receptors (dry mouth, reduction in forming of gastric juice) and some 5-HT receptors (different anti-allergic/gastrointestinal actions). Because it acts on so many receptors, chlorpromazine is often referred to as "dirty drug", whereas the atypical neuroleptic amisulpride for example acts only on central D2/D3-receptors and is therefore a "clean drug". This distinction is not a positive or negative value judgment on the drug, rather it is a neutral term which merely describes the agent's relative pharmacology. [edit] History The drug had been developed by Laboratoires Rhône-Poulenc in 1950 but they sold the rights in 1952 to Smith-Kline & French (today's GlaxoSmithKline). The drug was being sold as an antiemetic when its other use was noted. Smith-Kline was quick to encourage clinical trials and in 1954 the drug was approved in the US for psychiatric treatment. Over 100 million people were treated but the popularity of the drug fell from the late 1960s as the severe extrapyramidal side effects and tardive dyskinesia became more of a concern. From chlorpromazine a number of other similar neuroleptics were developed (e.g. triflupromazine, trifluoperazine). Previously used as an antihistamine and antiemetic its effects on mental state were first reported by the French doctor Henri Laborit in 1951 or 1952 (different sources) as sedation without narcosis. It became possible to cause 'artificial hibernation' in patients, if used as a cocktail together with pethidine and hydergine. Patients with shock, severe trauma or burns, become, if treated so, sedated, without anxiety and unreponsive/indifferent to painful external stimuli like minor surgical interventions. It was first used for psychiatric patients by Pierre Deniker and Jean Delay in 1953. Drug treatment with chlorpromazine went beyond simple sedation with patients showing improvements in thinking and emotional behaviour. Ironically, the antipsychotic properties of chlorpromazine appear to be unrelated to its sedative properties. During long term therapy some tolerance to the sedation effect develops. Chlorpromazine substituted and eclipsed the old therapies of electro- and insulin shocks and other methods such as psychosurgical means (lobotomy) causing permanent brain injury. Chlorpromazine has given approximately 70% of all schizophrenic patients a complete remission or near so and a normal, gainful human life. Before the era of neuroleptics, starting with chlorpromazine, positive long-term results for psychotic patients were only 20%. [edit] Side effects Side effects of chlorpromazine are typical of early generation neuroleptics. They include extrapyramidal side effects such as tardive dyskinesia and akathisia. A particularly severe side effect is the neuroleptic malignant syndrome which occurs in approximately 0.05% and can be fatal. Also, chlorpromazine may lower seizure threshold. Additional side effects include dry mouth, increased appetite with weight gain, constipation and urinary retention. Glucose tolerance may be impaired. An allergic skin rash and photosensitivity may occur. Other important and severe side effects are a strong reduction in the number of white blood cells, referred to as leukopenia, or, in extreme cases, even agranulocytosis may result, which may lead to death via uncontrollable infections and/or sepsis. Chlorpromazine is the neuroleptic drug with the highest rates (0.5% to 1%) of liver toxicity of the cholestatic type. The sedation effect combined with indifference to physical stimuli, anecdotally known as the "thorazine shuffle," has long been associated with the drug. The image of psychiatric patients staggering mute around a padded cell has earned those particular side effects a place in mainstream pop culture. [edit] Interactions Chlorpromazine intensifies the central depressive action of drugs with such activity (tranquilizers, barbiturates, narcotics, antihistamines, OTC-antiemetics etc.). A dose reduction of chlorpromazine or the other drug may be necessary. Chlorpromazine also intensifies the actions and undesired side effects of antihypertensive medications and anticholinergic drugs. The combination of chlorpromazine with other antipsychotics may result in increased central depression, hypotension and extrapyramidal side effects, but may sometimes enhance the clinical results of therapy. The anti-worm drug (antihelminthic) piperazine may intensify extrapyramidal side effects. In general, all neuroleptics may lead to seizures in combination with tramadol (Ultram). Chlorpromazine may increase the insulin needs of diabetic patients. Drugs like SSRIs, St. John's Wort and barbiturates can inhibit various CYP-isoenzymes such as CYP2D6, needed for metabolization of chlorpromazine and/or its metabolites. Theoretically, this should increase the half-lives of chlorpromazine and possibly its metabolites, dosing changes necessary. The exact clinical significance of this enzyme induction and its therapeutic consequences are unknown at present time and remain to be evaluated. [edit] Uses [edit] Common uses [edit] As an antipsychotic The use of chlorpromazine has been primarily replaced by newer generation of atypical antipsychotics which have an improved side effect profile. Chlorpromazine is classified as a low- to moderate-potency antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of manic depression as well as amphetamine-induced psychoses. Chlorpromazine formerly was the drug of choice to treat LSD (and other psychedelic/hallucinogen) intoxication in a hospital setting, resulting in it gaining an erroneous reputation as the LSD "antidote". Now haloperidol is more commonly used in such situations. [edit] Other uses It has also been used in porphyria, as part of tetanus treatment and for behavioral problems in children. It still is well recommended for short term management of severe anxiety and aggressive episodes. Resistant and severe hiccups, severe nausea/emesis and preanesthetic conditioning have been other indications in the past. It can be used to treat amphetamine overdose. [1] [edit] Off-label and controversial uses Chlorpromazine is occasionally used off-label for treatment of severe migraine. Sometimes it is used in small doses to improve nausea/emesis opioid-treated cancer patients encounter and to intensify and prolong the analgesic action of the opioids given. Interestingly, it remains controversial whether or not chlorpromazine has its own analgesic properties. Analgesic properties may result from a central action on the hypothalamus; the patient may feel the pain much less than before. Other mechanisms may be an interaction with opioid receptors centrally and/or in the spinal cord. Some experts on the contrary say that chlorpromazine, like other phenothiazines, may even have antianalgesic properties. Chlorpromazine has been proposed as useful in newborns for the treatment of opioid withdrawal, if the mother was opioid-dependent. The latter indication remains highly controversial. Chlorpromazine, as well as other neuroleptics, may also be used to alleviate the symptoms of alcohol withdrawal (chlorpromazine may lower the seizure-threshold in alcoholics). It has a unique action in cholera, reducing the loss of water by approximately 30%. In Germany, the brand of chlorpromazine drug Propaphenin® has additional indications for insomnia and itching skin disease. [edit] Veterinary uses Chlorpromazine is primarily used as an antiemetic in dogs and cats. It is also sometimes used as a preanesthetic and muscle relaxant in cattle, swine, sheep, and goats. It is generally contraindicated for use with horses, due to a high incidence of ataxia and altered mentation. [edit] Dosage In any case, use is determined by an attending physician. The following information is intended to serve as a guideline: A wide range is covered from 25 mg oral or intramuscular for mild sedation, every 8 hours, up to 100 mg every 6 hours for severely disturbed patients. Different qualified sources give 800 mg/day to 1,200 mg/day as highest dose. At least there is one small clinical trial in treatment-resistant patients with a daily dose of 1,200 mg chlorpromazine (and 4 mg Benztropine to counteract early extrapyramidal side effects, which were anticipated with this unusual high chlorpromazine dose). Initial doses should be low and be increased gradually. It is recommended that most of the daily dose (e.g. 2/3) is given at bedtime for maximum hypnotic activity and minimal daytime sedation and hypotension. In the USA there are controlled release forms of Thorazine (e.g. 300 mg). After the individual dose is well established, such a CR capsule can be given with the evening meal as a single dose, covering the next 24 hours. The lowest dosage compatible with good therapeutic effect should be given. Dosage in ambulatory patients should be particularly low (minimizing sedation and hypotension). The direct i.v.-injection of undiluted solution is contraindicated (massive fall in blood pressure, cardiovascular collapse), for i.v.-infusion of dilutions the (hospitalized) patient should be lying and the infusion rate should be as slow as possible. Afterwards the patient should rest in the lying position for at least 30 minutes. [edit] Necessary examinations and laboratory checks during treatment All patients treated with chlorpromazine on a long-term-basis should have regularly checked their blood-pressure, pulse rate, laboratory-tests (liver function tests, kidney-values, blood cell counts including differenciated white blood counts, counts of red blood cells and thrombocytes), ECG and EEG. The frequency of all checks should be determined for the individual patient and may be done in shorter intervals during the first 3 months of treatment and less often afterwards. Some side effects seem to appear more frequently during the first months of therapy (sedation, hypotension, liver damage) while others do not (e.g. tardive dyskinesia). [edit] Discontinuation of treatment Also, in regular intervals the treating physician should evaluate whether continued treatment is needed. If not, the drug should never be stopped suddenly, due to very unpleasant 'withdrawal-symptoms', such as agitation, sleeplessness, states of anxiety, etc. However, these symptoms definitely do not indicate psychological or physical dependence. The dose should rather be slowly tapered down at a rate of approximately 20–25% per week or even slower to avoid the aforementioned bothersome symptoms. Chlorpromazine is derived from phenothiazine, and has an aliphatic side chain, typical for low to middle potency neuroleptics. The oral bioavailability is estimated to be 30–50% due to extensive first pass metabolization in the liver. Its elimination-halflife is 16–30 hours. It has many active metabolites (approx. 75 different ones) with greatly varying halflives and own pharmacological profiles. The CYP-450 isoenzymes 1A2 and 2D6 are needed for metabolization of chlorpromazine and the subtype 2D6 is inhibited by chlorpromazine (NB: possible interactions with other drugs). Answered by Etsuko Berkson 2 years ago.


What are some reasons why a person might be prescribed 200 mg of thorazine?
...from a medical prospective. Asked by Nana Ulmer 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Marylou Wares 2 years ago.

The warding off man or woman will have angry through a comment the have shyed away from man or woman made. The warding off man or woman will have a few prejudice towards the have shyed away from man or woman. The have shyed away from man or woman might remind the warding off man or woman of an ex-boyfriend or ex-female friend or different man or woman who the warding off man or woman desires to omit. Maybe anybody instructed the warding off man or woman that the have shyed away from man or woman does not like him/her. But the object is, why do you care? Answered by Arthur Ezer 2 years ago.

It's an anti-psychotic, for bipolar disorder or schizophrenia. Answered by Eugene Dreckman 2 years ago.


What is Thorazine, Lorazepam and Compazine? What are they used for?
Asked by Keila Valis 2 years ago.

Chlorpromazine is classified as a low-potency typical antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of bipolar disorder, as well as amphetamine-induced psychoses. Low-potency antipsychotics have more anticholinergic side effects, such as dry mouth, sedation, and constipation, and lower rates of extrapyramidal side effects, while high-potency antipsychotics (such as haloperidol) have the reverse profile. Chlorpromazine has also been used in porphyria and as part of tetanus treatment. It still is recommended for short-term management of severe anxiety and psychotic aggression. Resistant and severe hiccups, severe nausea/emesis, and preanesthetic conditioning are other uses. Symptoms of delirium in medically-hospitalized AIDS patients have been effectively treated with low doses of chlorpromazine Answered by Fabiola Collica 2 years ago.

They are antipsycotic drugs used to treat manic depression, schizophrenia Answered by Phillip Hannigan 2 years ago.


Is 25 mg of Thorazine safe to take for anxiety?
Asked by Loris Wintle 2 years ago.

Thorazine, at 25 mg, is used for chronic hiccups, nausea and vomitting, sedation before surgery, and sometimes anxiety. However, it is anti-psychotic, a tranquilizer, and very old school, so if it was not prescribed to you, don't tske it. This may just be a question of general curiosity, but if you need meds for anxiety, there are more suitable ones than thorazine. See the doc. to get the right one for you! Answered by Trudie Nocket 2 years ago.

Thorazine is not an anti-anxiety drug. It is an antipsychotic drug. Please do not take ANY prescription medication unless under the direction of your personal physician. Answered by Kris Walizer 2 years ago.

I think I would speak to a Pharmacist before listening to someone on Yahoo answers. Answered by Joana Waldall 2 years ago.

The potential for causing chronic movement disorders makes it far from ideal. Answered by Laquita Mikulich 2 years ago.

It has more potential side effects than newer drugs. For example, seizures, heat exhaustion, drowsiness. Answered by Dania Paeth 2 years ago.


Is it true that Thorazine is as dangerous and the Psychiatric critics say it is?
From Psychiatric critics they criticize Thorazine a lot and say it messes people up like Lobotomy. Here is an example website criticizing Thorazine: http://www.sntp.net/drugs/thorazine.htm Asked by Valeri Riippi 2 years ago.

Thorazine is no more dangerous than the others. Staying on it for too long can lead to specific complications, which is true with other anti-psychotics. It isn't used as much these days, but it is still a consideration for some people. It's OK to critisize thorazine, but no more so than for other such drugs. Answered by Rafael Patts 2 years ago.

Wow! Normally, I don't answer questions that want to learn more and more detail. As in your case, because they require a long process, and it is the risk of not solve all of yours problems. I would suggest to proceed analytically with the help of keywords to be included in Yahoo! From what you climb, narrowing the field with new keywords, until you will be fully satisfied. good luck! Answered by Jeane Zarate 2 years ago.


Is Thorazine(Chlorpromazine) an older anti-psychotic?
I was prescribed this recently for Bipolar Disorder. Is it an older anti-psychotic?Thanks Asked by Danial Creveling 2 years ago.

Thorazine was one of the first anti-psychotics, created in 1950. It is still occasionally used in the treatment of schizophrenia and bipolar disorder, but not as often as it was a few decades ago. It's a low potency anti-psychotic, so there is a lower chance of experiencing unwanted side effects. Answered by Modesta Dumdei 2 years ago.


How long will thorazine take to get in my urine stream?
i want to take a thorazine but i have a drug test at 10:00am and dont know what time yo take it so i can pass the drug test and still take it tonight Asked by Gerri Petts 2 years ago.

To my understanding, Thorazine is an anti-psychotic medication. It's not typically screened for on a drug test. However, if you do register with a false positive in another drug category as a result of this medication, all you have to do is show proof of a prescription and you're in the clear. Thorazine is excreted primarily through the urine and has a half-life from 10 to 40 hours. Answered by Karin Ponder 2 years ago.

You can't wait until after the test to take it - just to be on the safe side? Answered by Scotty Cherney 2 years ago.


About Thorazine/Largactil?
I have read alot about this drug, but I would like to hear from somone that has actually used it, or someone who knows someone who has used it.How sedating/tranquilizing is it? What are the main side-effects, and what pills do I need to counteract these side-effects? Asked by Lael Mutschler 2 years ago.

About counteraction - I'm not sure. You'd have to take it to know if you'd have any counteractions, first. I took Thorazine for about a month for sleep. It never made me tired. It would, however, keep me asleep for 8-12 hrs once I laid down and fell asleep. Not a good drug if you need to be knocked out (in my opinion). I'm sure you've heard it called 'the chemical lobotomy'. I didn't feel like it erased too much of my personality, and I was still heavily addicted to drugs and it never made me seek/want drugs less. I really don't remember much from taking it. I snorted it once, and it burned like a SOB, but it knocked me out right away. Answered by Jody Pechal 2 years ago.


Mrs S. has been taking Thorazine for about 1 year?
She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the... Asked by Gwendolyn Alexnder 2 years ago.

She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the nursing diagnosis for this patient. a) What interventions would be used for this diagnosis? b) How would the nurse evaluate the outcome of the interventions? Answered by Wilbur Gennett 2 years ago.

thorazine is bound to have more severe side effects.. clozaril is an atypical antipsychotic drug, so it will be LESS likely to cause tardive dyskenesia and akathisia and other similarly devastating side effects (thanks to its anticholinergic properties). However, there is recent evidence that such drugs may increase the likelihood of metabolic disturbances (leading to diabetes) and cardiovascular disease. There are also sexual functioning side effects, but that is common to many psychotropic meds...Note that slow titration of dosing of Clozaril significantly decreases the likelihood of orthostatic hypotension, so the switch is right on the money for this mrs. s....... I would say the switch from thorazine to clozaril is not a bad idea. I have no idea what you mean by "knowledge deficit" and "nursing diagnosis", I'm coming from a clinical psych perspective, but hope this helps! Answered by Gerard Lishman 2 years ago.


What is thorazine used for?
Asked by Hollis Biggerstaff 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Freeda Souliere 2 years ago.

Thorazine Uses Answered by Donnie Crumpacker 2 years ago.

I don't know all of its uses, but I was given Thorazine for migraines. Answered by Rashad Aldinger 2 years ago.

It is a old anti-psychotic. They use to use it a lot in psychiatric hospitals to calm down patients. It is also used for migraines at times. Answered by Vi Maust 2 years ago.

To mess with kids minds! Answered by Carin Bugge 2 years ago.

PAIN!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!... Answered by Vivian Mattix 2 years ago.

Chlorpromazine was the first antipsychotic drug, used during the 1950s and 1960s. Used as chlorpromazine hydrochloride and sold under the tradenames Largactil® and Thorazine®, it has sedative, hypotensive and antiemetic properties as well as anticholinergic and antidopaminergic effects. It has also anxiolytic (alleviation of anxiety) properties. Today, chlorpromazine is considered a typical antipsychotic. Chlorpromazine acts as an antagonist (blocking agent) on different postsynaptic receptors: on dopaminergic-receptors (subtypes D1, D2, D3 and D4, different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), on alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism—controversial), and on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side effects). Additionally, chlorpromazine is a weak presynaptic inhibitor of dopamine reuptake, which may lead to (mild) antidepressive and antiparkinsonian effects. This action could also account for psychomotor agitation and amplification of psychosis (very rarely noted in clinical use). [edit] Peripheral Antagonist to H1 receptors (antiallergic effects), H2 receptors (reduction of forming of gastric juice), M1/M2-receptors (dry mouth, reduction in forming of gastric juice) and some 5-HT receptors (different anti-allergic/gastrointestinal actions). Because it acts on so many receptors, chlorpromazine is often referred to as "dirty drug", whereas the atypical neuroleptic amisulpride for example acts only on central D2/D3-receptors and is therefore a "clean drug". This distinction is not a positive or negative value judgment on the drug, rather it is a neutral term which merely describes the agent's relative pharmacology. [edit] History The drug had been developed by Laboratoires Rhône-Poulenc in 1950 but they sold the rights in 1952 to Smith-Kline & French (today's GlaxoSmithKline). The drug was being sold as an antiemetic when its other use was noted. Smith-Kline was quick to encourage clinical trials and in 1954 the drug was approved in the US for psychiatric treatment. Over 100 million people were treated but the popularity of the drug fell from the late 1960s as the severe extrapyramidal side effects and tardive dyskinesia became more of a concern. From chlorpromazine a number of other similar neuroleptics were developed (e.g. triflupromazine, trifluoperazine). Previously used as an antihistamine and antiemetic its effects on mental state were first reported by the French doctor Henri Laborit in 1951 or 1952 (different sources) as sedation without narcosis. It became possible to cause 'artificial hibernation' in patients, if used as a cocktail together with pethidine and hydergine. Patients with shock, severe trauma or burns, become, if treated so, sedated, without anxiety and unreponsive/indifferent to painful external stimuli like minor surgical interventions. It was first used for psychiatric patients by Pierre Deniker and Jean Delay in 1953. Drug treatment with chlorpromazine went beyond simple sedation with patients showing improvements in thinking and emotional behaviour. Ironically, the antipsychotic properties of chlorpromazine appear to be unrelated to its sedative properties. During long term therapy some tolerance to the sedation effect develops. Chlorpromazine substituted and eclipsed the old therapies of electro- and insulin shocks and other methods such as psychosurgical means (lobotomy) causing permanent brain injury. Chlorpromazine has given approximately 70% of all schizophrenic patients a complete remission or near so and a normal, gainful human life. Before the era of neuroleptics, starting with chlorpromazine, positive long-term results for psychotic patients were only 20%. [edit] Side effects Side effects of chlorpromazine are typical of early generation neuroleptics. They include extrapyramidal side effects such as tardive dyskinesia and akathisia. A particularly severe side effect is the neuroleptic malignant syndrome which occurs in approximately 0.05% and can be fatal. Also, chlorpromazine may lower seizure threshold. Additional side effects include dry mouth, increased appetite with weight gain, constipation and urinary retention. Glucose tolerance may be impaired. An allergic skin rash and photosensitivity may occur. Other important and severe side effects are a strong reduction in the number of white blood cells, referred to as leukopenia, or, in extreme cases, even agranulocytosis may result, which may lead to death via uncontrollable infections and/or sepsis. Chlorpromazine is the neuroleptic drug with the highest rates (0.5% to 1%) of liver toxicity of the cholestatic type. The sedation effect combined with indifference to physical stimuli, anecdotally known as the "thorazine shuffle," has long been associated with the drug. The image of psychiatric patients staggering mute around a padded cell has earned those particular side effects a place in mainstream pop culture. [edit] Interactions Chlorpromazine intensifies the central depressive action of drugs with such activity (tranquilizers, barbiturates, narcotics, antihistamines, OTC-antiemetics etc.). A dose reduction of chlorpromazine or the other drug may be necessary. Chlorpromazine also intensifies the actions and undesired side effects of antihypertensive medications and anticholinergic drugs. The combination of chlorpromazine with other antipsychotics may result in increased central depression, hypotension and extrapyramidal side effects, but may sometimes enhance the clinical results of therapy. The anti-worm drug (antihelminthic) piperazine may intensify extrapyramidal side effects. In general, all neuroleptics may lead to seizures in combination with tramadol (Ultram). Chlorpromazine may increase the insulin needs of diabetic patients. Drugs like SSRIs, St. John's Wort and barbiturates can inhibit various CYP-isoenzymes such as CYP2D6, needed for metabolization of chlorpromazine and/or its metabolites. Theoretically, this should increase the half-lives of chlorpromazine and possibly its metabolites, dosing changes necessary. The exact clinical significance of this enzyme induction and its therapeutic consequences are unknown at present time and remain to be evaluated. [edit] Uses [edit] Common uses [edit] As an antipsychotic The use of chlorpromazine has been primarily replaced by newer generation of atypical antipsychotics which have an improved side effect profile. Chlorpromazine is classified as a low- to moderate-potency antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of manic depression as well as amphetamine-induced psychoses. Chlorpromazine formerly was the drug of choice to treat LSD (and other psychedelic/hallucinogen) intoxication in a hospital setting, resulting in it gaining an erroneous reputation as the LSD "antidote". Now haloperidol is more commonly used in such situations. [edit] Other uses It has also been used in porphyria, as part of tetanus treatment and for behavioral problems in children. It still is well recommended for short term management of severe anxiety and aggressive episodes. Resistant and severe hiccups, severe nausea/emesis and preanesthetic conditioning have been other indications in the past. It can be used to treat amphetamine overdose. [1] [edit] Off-label and controversial uses Chlorpromazine is occasionally used off-label for treatment of severe migraine. Sometimes it is used in small doses to improve nausea/emesis opioid-treated cancer patients encounter and to intensify and prolong the analgesic action of the opioids given. Interestingly, it remains controversial whether or not chlorpromazine has its own analgesic properties. Analgesic properties may result from a central action on the hypothalamus; the patient may feel the pain much less than before. Other mechanisms may be an interaction with opioid receptors centrally and/or in the spinal cord. Some experts on the contrary say that chlorpromazine, like other phenothiazines, may even have antianalgesic properties. Chlorpromazine has been proposed as useful in newborns for the treatment of opioid withdrawal, if the mother was opioid-dependent. The latter indication remains highly controversial. Chlorpromazine, as well as other neuroleptics, may also be used to alleviate the symptoms of alcohol withdrawal (chlorpromazine may lower the seizure-threshold in alcoholics). It has a unique action in cholera, reducing the loss of water by approximately 30%. In Germany, the brand of chlorpromazine drug Propaphenin® has additional indications for insomnia and itching skin disease. [edit] Veterinary uses Chlorpromazine is primarily used as an antiemetic in dogs and cats. It is also sometimes used as a preanesthetic and muscle relaxant in cattle, swine, sheep, and goats. It is generally contraindicated for use with horses, due to a high incidence of ataxia and altered mentation. [edit] Dosage In any case, use is determined by an attending physician. The following information is intended to serve as a guideline: A wide range is covered from 25 mg oral or intramuscular for mild sedation, every 8 hours, up to 100 mg every 6 hours for severely disturbed patients. Different qualified sources give 800 mg/day to 1,200 mg/day as highest dose. At least there is one small clinical trial in treatment-resistant patients with a daily dose of 1,200 mg chlorpromazine (and 4 mg Benztropine to counteract early extrapyramidal side effects, which were anticipated with this unusual high chlorpromazine dose). Initial doses should be low and be increased gradually. It is recommended that most of the daily dose (e.g. 2/3) is given at bedtime for maximum hypnotic activity and minimal daytime sedation and hypotension. In the USA there are controlled release forms of Thorazine (e.g. 300 mg). After the individual dose is well established, such a CR capsule can be given with the evening meal as a single dose, covering the next 24 hours. The lowest dosage compatible with good therapeutic effect should be given. Dosage in ambulatory patients should be particularly low (minimizing sedation and hypotension). The direct i.v.-injection of undiluted solution is contraindicated (massive fall in blood pressure, cardiovascular collapse), for i.v.-infusion of dilutions the (hospitalized) patient should be lying and the infusion rate should be as slow as possible. Afterwards the patient should rest in the lying position for at least 30 minutes. [edit] Necessary examinations and laboratory checks during treatment All patients treated with chlorpromazine on a long-term-basis should have regularly checked their blood-pressure, pulse rate, laboratory-tests (liver function tests, kidney-values, blood cell counts including differenciated white blood counts, counts of red blood cells and thrombocytes), ECG and EEG. The frequency of all checks should be determined for the individual patient and may be done in shorter intervals during the first 3 months of treatment and less often afterwards. Some side effects seem to appear more frequently during the first months of therapy (sedation, hypotension, liver damage) while others do not (e.g. tardive dyskinesia). [edit] Discontinuation of treatment Also, in regular intervals the treating physician should evaluate whether continued treatment is needed. If not, the drug should never be stopped suddenly, due to very unpleasant 'withdrawal-symptoms', such as agitation, sleeplessness, states of anxiety, etc. However, these symptoms definitely do not indicate psychological or physical dependence. The dose should rather be slowly tapered down at a rate of approximately 20–25% per week or even slower to avoid the aforementioned bothersome symptoms. Chlorpromazine is derived from phenothiazine, and has an aliphatic side chain, typical for low to middle potency neuroleptics. The oral bioavailability is estimated to be 30–50% due to extensive first pass metabolization in the liver. Its elimination-halflife is 16–30 hours. It has many active metabolites (approx. 75 different ones) with greatly varying halflives and own pharmacological profiles. The CYP-450 isoenzymes 1A2 and 2D6 are needed for metabolization of chlorpromazine and the subtype 2D6 is inhibited by chlorpromazine (NB: possible interactions with other drugs). Answered by Rosalind Boyas 2 years ago.


What are some reasons why a person might be prescribed 200 mg of thorazine?
...from a medical prospective. Asked by Sergio Harbin 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Darren Ingmire 2 years ago.

The warding off man or woman will have angry through a comment the have shyed away from man or woman made. The warding off man or woman will have a few prejudice towards the have shyed away from man or woman. The have shyed away from man or woman might remind the warding off man or woman of an ex-boyfriend or ex-female friend or different man or woman who the warding off man or woman desires to omit. Maybe anybody instructed the warding off man or woman that the have shyed away from man or woman does not like him/her. But the object is, why do you care? Answered by Demetrius Schemm 2 years ago.

It's an anti-psychotic, for bipolar disorder or schizophrenia. Answered by Venice Burbridge 2 years ago.


What is Thorazine, Lorazepam and Compazine? What are they used for?
Asked by Sanjuanita Didonatis 2 years ago.

Chlorpromazine is classified as a low-potency typical antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of bipolar disorder, as well as amphetamine-induced psychoses. Low-potency antipsychotics have more anticholinergic side effects, such as dry mouth, sedation, and constipation, and lower rates of extrapyramidal side effects, while high-potency antipsychotics (such as haloperidol) have the reverse profile. Chlorpromazine has also been used in porphyria and as part of tetanus treatment. It still is recommended for short-term management of severe anxiety and psychotic aggression. Resistant and severe hiccups, severe nausea/emesis, and preanesthetic conditioning are other uses. Symptoms of delirium in medically-hospitalized AIDS patients have been effectively treated with low doses of chlorpromazine Answered by Izetta Carretero 2 years ago.

They are antipsycotic drugs used to treat manic depression, schizophrenia Answered by Sommer Bramel 2 years ago.


Is 25 mg of Thorazine safe to take for anxiety?
Asked by Alison Sams 2 years ago.

Thorazine, at 25 mg, is used for chronic hiccups, nausea and vomitting, sedation before surgery, and sometimes anxiety. However, it is anti-psychotic, a tranquilizer, and very old school, so if it was not prescribed to you, don't tske it. This may just be a question of general curiosity, but if you need meds for anxiety, there are more suitable ones than thorazine. See the doc. to get the right one for you! Answered by Alvin Cumley 2 years ago.

Thorazine is not an anti-anxiety drug. It is an antipsychotic drug. Please do not take ANY prescription medication unless under the direction of your personal physician. Answered by Thomas Zevallos 2 years ago.

I think I would speak to a Pharmacist before listening to someone on Yahoo answers. Answered by Jeneva Havlick 2 years ago.

The potential for causing chronic movement disorders makes it far from ideal. Answered by Elicia Megeath 2 years ago.

It has more potential side effects than newer drugs. For example, seizures, heat exhaustion, drowsiness. Answered by Marla Siebold 2 years ago.


Is it true that Thorazine is as dangerous and the Psychiatric critics say it is?
From Psychiatric critics they criticize Thorazine a lot and say it messes people up like Lobotomy. Here is an example website criticizing Thorazine: http://www.sntp.net/drugs/thorazine.htm Asked by Belia Teoh 2 years ago.

Thorazine is no more dangerous than the others. Staying on it for too long can lead to specific complications, which is true with other anti-psychotics. It isn't used as much these days, but it is still a consideration for some people. It's OK to critisize thorazine, but no more so than for other such drugs. Answered by Dominique Mochel 2 years ago.

Wow! Normally, I don't answer questions that want to learn more and more detail. As in your case, because they require a long process, and it is the risk of not solve all of yours problems. I would suggest to proceed analytically with the help of keywords to be included in Yahoo! From what you climb, narrowing the field with new keywords, until you will be fully satisfied. good luck! Answered by Maureen Amendola 2 years ago.


Is Thorazine(Chlorpromazine) an older anti-psychotic?
I was prescribed this recently for Bipolar Disorder. Is it an older anti-psychotic?Thanks Asked by Cristina Rieff 2 years ago.

Thorazine was one of the first anti-psychotics, created in 1950. It is still occasionally used in the treatment of schizophrenia and bipolar disorder, but not as often as it was a few decades ago. It's a low potency anti-psychotic, so there is a lower chance of experiencing unwanted side effects. Answered by Barney Prohaska 2 years ago.


How long will thorazine take to get in my urine stream?
i want to take a thorazine but i have a drug test at 10:00am and dont know what time yo take it so i can pass the drug test and still take it tonight Asked by Lane Harvat 2 years ago.

To my understanding, Thorazine is an anti-psychotic medication. It's not typically screened for on a drug test. However, if you do register with a false positive in another drug category as a result of this medication, all you have to do is show proof of a prescription and you're in the clear. Thorazine is excreted primarily through the urine and has a half-life from 10 to 40 hours. Answered by Stephenie Ossenfort 2 years ago.

You can't wait until after the test to take it - just to be on the safe side? Answered by Melodi Bownds 2 years ago.


About Thorazine/Largactil?
I have read alot about this drug, but I would like to hear from somone that has actually used it, or someone who knows someone who has used it.How sedating/tranquilizing is it? What are the main side-effects, and what pills do I need to counteract these side-effects? Asked by Henrietta Atcheson 2 years ago.

About counteraction - I'm not sure. You'd have to take it to know if you'd have any counteractions, first. I took Thorazine for about a month for sleep. It never made me tired. It would, however, keep me asleep for 8-12 hrs once I laid down and fell asleep. Not a good drug if you need to be knocked out (in my opinion). I'm sure you've heard it called 'the chemical lobotomy'. I didn't feel like it erased too much of my personality, and I was still heavily addicted to drugs and it never made me seek/want drugs less. I really don't remember much from taking it. I snorted it once, and it burned like a SOB, but it knocked me out right away. Answered by Meaghan Walkowski 2 years ago.


Mrs S. has been taking Thorazine for about 1 year?
She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the... Asked by Joslyn Cretsinger 2 years ago.

She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the nursing diagnosis for this patient. a) What interventions would be used for this diagnosis? b) How would the nurse evaluate the outcome of the interventions? Answered by Corrine Broaden 2 years ago.

thorazine is bound to have more severe side effects.. clozaril is an atypical antipsychotic drug, so it will be LESS likely to cause tardive dyskenesia and akathisia and other similarly devastating side effects (thanks to its anticholinergic properties). However, there is recent evidence that such drugs may increase the likelihood of metabolic disturbances (leading to diabetes) and cardiovascular disease. There are also sexual functioning side effects, but that is common to many psychotropic meds...Note that slow titration of dosing of Clozaril significantly decreases the likelihood of orthostatic hypotension, so the switch is right on the money for this mrs. s....... I would say the switch from thorazine to clozaril is not a bad idea. I have no idea what you mean by "knowledge deficit" and "nursing diagnosis", I'm coming from a clinical psych perspective, but hope this helps! Answered by Denisha Frontz 2 years ago.


What is thorazine used for?
Asked by Kathe Jarboe 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Monika Stelzl 2 years ago.

Thorazine Uses Answered by Etsuko Hepperly 2 years ago.

I don't know all of its uses, but I was given Thorazine for migraines. Answered by Kenia Degrace 2 years ago.

It is a old anti-psychotic. They use to use it a lot in psychiatric hospitals to calm down patients. It is also used for migraines at times. Answered by Laine Brazille 2 years ago.

To mess with kids minds! Answered by Fransisca Daloia 2 years ago.

PAIN!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!... Answered by Pam Stoppenbach 2 years ago.

Chlorpromazine was the first antipsychotic drug, used during the 1950s and 1960s. Used as chlorpromazine hydrochloride and sold under the tradenames Largactil® and Thorazine®, it has sedative, hypotensive and antiemetic properties as well as anticholinergic and antidopaminergic effects. It has also anxiolytic (alleviation of anxiety) properties. Today, chlorpromazine is considered a typical antipsychotic. Chlorpromazine acts as an antagonist (blocking agent) on different postsynaptic receptors: on dopaminergic-receptors (subtypes D1, D2, D3 and D4, different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), on alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism—controversial), and on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side effects). Additionally, chlorpromazine is a weak presynaptic inhibitor of dopamine reuptake, which may lead to (mild) antidepressive and antiparkinsonian effects. This action could also account for psychomotor agitation and amplification of psychosis (very rarely noted in clinical use). [edit] Peripheral Antagonist to H1 receptors (antiallergic effects), H2 receptors (reduction of forming of gastric juice), M1/M2-receptors (dry mouth, reduction in forming of gastric juice) and some 5-HT receptors (different anti-allergic/gastrointestinal actions). Because it acts on so many receptors, chlorpromazine is often referred to as "dirty drug", whereas the atypical neuroleptic amisulpride for example acts only on central D2/D3-receptors and is therefore a "clean drug". This distinction is not a positive or negative value judgment on the drug, rather it is a neutral term which merely describes the agent's relative pharmacology. [edit] History The drug had been developed by Laboratoires Rhône-Poulenc in 1950 but they sold the rights in 1952 to Smith-Kline & French (today's GlaxoSmithKline). The drug was being sold as an antiemetic when its other use was noted. Smith-Kline was quick to encourage clinical trials and in 1954 the drug was approved in the US for psychiatric treatment. Over 100 million people were treated but the popularity of the drug fell from the late 1960s as the severe extrapyramidal side effects and tardive dyskinesia became more of a concern. From chlorpromazine a number of other similar neuroleptics were developed (e.g. triflupromazine, trifluoperazine). Previously used as an antihistamine and antiemetic its effects on mental state were first reported by the French doctor Henri Laborit in 1951 or 1952 (different sources) as sedation without narcosis. It became possible to cause 'artificial hibernation' in patients, if used as a cocktail together with pethidine and hydergine. Patients with shock, severe trauma or burns, become, if treated so, sedated, without anxiety and unreponsive/indifferent to painful external stimuli like minor surgical interventions. It was first used for psychiatric patients by Pierre Deniker and Jean Delay in 1953. Drug treatment with chlorpromazine went beyond simple sedation with patients showing improvements in thinking and emotional behaviour. Ironically, the antipsychotic properties of chlorpromazine appear to be unrelated to its sedative properties. During long term therapy some tolerance to the sedation effect develops. Chlorpromazine substituted and eclipsed the old therapies of electro- and insulin shocks and other methods such as psychosurgical means (lobotomy) causing permanent brain injury. Chlorpromazine has given approximately 70% of all schizophrenic patients a complete remission or near so and a normal, gainful human life. Before the era of neuroleptics, starting with chlorpromazine, positive long-term results for psychotic patients were only 20%. [edit] Side effects Side effects of chlorpromazine are typical of early generation neuroleptics. They include extrapyramidal side effects such as tardive dyskinesia and akathisia. A particularly severe side effect is the neuroleptic malignant syndrome which occurs in approximately 0.05% and can be fatal. Also, chlorpromazine may lower seizure threshold. Additional side effects include dry mouth, increased appetite with weight gain, constipation and urinary retention. Glucose tolerance may be impaired. An allergic skin rash and photosensitivity may occur. Other important and severe side effects are a strong reduction in the number of white blood cells, referred to as leukopenia, or, in extreme cases, even agranulocytosis may result, which may lead to death via uncontrollable infections and/or sepsis. Chlorpromazine is the neuroleptic drug with the highest rates (0.5% to 1%) of liver toxicity of the cholestatic type. The sedation effect combined with indifference to physical stimuli, anecdotally known as the "thorazine shuffle," has long been associated with the drug. The image of psychiatric patients staggering mute around a padded cell has earned those particular side effects a place in mainstream pop culture. [edit] Interactions Chlorpromazine intensifies the central depressive action of drugs with such activity (tranquilizers, barbiturates, narcotics, antihistamines, OTC-antiemetics etc.). A dose reduction of chlorpromazine or the other drug may be necessary. Chlorpromazine also intensifies the actions and undesired side effects of antihypertensive medications and anticholinergic drugs. The combination of chlorpromazine with other antipsychotics may result in increased central depression, hypotension and extrapyramidal side effects, but may sometimes enhance the clinical results of therapy. The anti-worm drug (antihelminthic) piperazine may intensify extrapyramidal side effects. In general, all neuroleptics may lead to seizures in combination with tramadol (Ultram). Chlorpromazine may increase the insulin needs of diabetic patients. Drugs like SSRIs, St. John's Wort and barbiturates can inhibit various CYP-isoenzymes such as CYP2D6, needed for metabolization of chlorpromazine and/or its metabolites. Theoretically, this should increase the half-lives of chlorpromazine and possibly its metabolites, dosing changes necessary. The exact clinical significance of this enzyme induction and its therapeutic consequences are unknown at present time and remain to be evaluated. [edit] Uses [edit] Common uses [edit] As an antipsychotic The use of chlorpromazine has been primarily replaced by newer generation of atypical antipsychotics which have an improved side effect profile. Chlorpromazine is classified as a low- to moderate-potency antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of manic depression as well as amphetamine-induced psychoses. Chlorpromazine formerly was the drug of choice to treat LSD (and other psychedelic/hallucinogen) intoxication in a hospital setting, resulting in it gaining an erroneous reputation as the LSD "antidote". Now haloperidol is more commonly used in such situations. [edit] Other uses It has also been used in porphyria, as part of tetanus treatment and for behavioral problems in children. It still is well recommended for short term management of severe anxiety and aggressive episodes. Resistant and severe hiccups, severe nausea/emesis and preanesthetic conditioning have been other indications in the past. It can be used to treat amphetamine overdose. [1] [edit] Off-label and controversial uses Chlorpromazine is occasionally used off-label for treatment of severe migraine. Sometimes it is used in small doses to improve nausea/emesis opioid-treated cancer patients encounter and to intensify and prolong the analgesic action of the opioids given. Interestingly, it remains controversial whether or not chlorpromazine has its own analgesic properties. Analgesic properties may result from a central action on the hypothalamus; the patient may feel the pain much less than before. Other mechanisms may be an interaction with opioid receptors centrally and/or in the spinal cord. Some experts on the contrary say that chlorpromazine, like other phenothiazines, may even have antianalgesic properties. Chlorpromazine has been proposed as useful in newborns for the treatment of opioid withdrawal, if the mother was opioid-dependent. The latter indication remains highly controversial. Chlorpromazine, as well as other neuroleptics, may also be used to alleviate the symptoms of alcohol withdrawal (chlorpromazine may lower the seizure-threshold in alcoholics). It has a unique action in cholera, reducing the loss of water by approximately 30%. In Germany, the brand of chlorpromazine drug Propaphenin® has additional indications for insomnia and itching skin disease. [edit] Veterinary uses Chlorpromazine is primarily used as an antiemetic in dogs and cats. It is also sometimes used as a preanesthetic and muscle relaxant in cattle, swine, sheep, and goats. It is generally contraindicated for use with horses, due to a high incidence of ataxia and altered mentation. [edit] Dosage In any case, use is determined by an attending physician. The following information is intended to serve as a guideline: A wide range is covered from 25 mg oral or intramuscular for mild sedation, every 8 hours, up to 100 mg every 6 hours for severely disturbed patients. Different qualified sources give 800 mg/day to 1,200 mg/day as highest dose. At least there is one small clinical trial in treatment-resistant patients with a daily dose of 1,200 mg chlorpromazine (and 4 mg Benztropine to counteract early extrapyramidal side effects, which were anticipated with this unusual high chlorpromazine dose). Initial doses should be low and be increased gradually. It is recommended that most of the daily dose (e.g. 2/3) is given at bedtime for maximum hypnotic activity and minimal daytime sedation and hypotension. In the USA there are controlled release forms of Thorazine (e.g. 300 mg). After the individual dose is well established, such a CR capsule can be given with the evening meal as a single dose, covering the next 24 hours. The lowest dosage compatible with good therapeutic effect should be given. Dosage in ambulatory patients should be particularly low (minimizing sedation and hypotension). The direct i.v.-injection of undiluted solution is contraindicated (massive fall in blood pressure, cardiovascular collapse), for i.v.-infusion of dilutions the (hospitalized) patient should be lying and the infusion rate should be as slow as possible. Afterwards the patient should rest in the lying position for at least 30 minutes. [edit] Necessary examinations and laboratory checks during treatment All patients treated with chlorpromazine on a long-term-basis should have regularly checked their blood-pressure, pulse rate, laboratory-tests (liver function tests, kidney-values, blood cell counts including differenciated white blood counts, counts of red blood cells and thrombocytes), ECG and EEG. The frequency of all checks should be determined for the individual patient and may be done in shorter intervals during the first 3 months of treatment and less often afterwards. Some side effects seem to appear more frequently during the first months of therapy (sedation, hypotension, liver damage) while others do not (e.g. tardive dyskinesia). [edit] Discontinuation of treatment Also, in regular intervals the treating physician should evaluate whether continued treatment is needed. If not, the drug should never be stopped suddenly, due to very unpleasant 'withdrawal-symptoms', such as agitation, sleeplessness, states of anxiety, etc. However, these symptoms definitely do not indicate psychological or physical dependence. The dose should rather be slowly tapered down at a rate of approximately 20–25% per week or even slower to avoid the aforementioned bothersome symptoms. Chlorpromazine is derived from phenothiazine, and has an aliphatic side chain, typical for low to middle potency neuroleptics. The oral bioavailability is estimated to be 30–50% due to extensive first pass metabolization in the liver. Its elimination-halflife is 16–30 hours. It has many active metabolites (approx. 75 different ones) with greatly varying halflives and own pharmacological profiles. The CYP-450 isoenzymes 1A2 and 2D6 are needed for metabolization of chlorpromazine and the subtype 2D6 is inhibited by chlorpromazine (NB: possible interactions with other drugs). Answered by Clarice Douet 2 years ago.


What are some reasons why a person might be prescribed 200 mg of thorazine?
...from a medical prospective. Asked by Enid Bylund 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Kylie Ornstein 2 years ago.

The warding off man or woman will have angry through a comment the have shyed away from man or woman made. The warding off man or woman will have a few prejudice towards the have shyed away from man or woman. The have shyed away from man or woman might remind the warding off man or woman of an ex-boyfriend or ex-female friend or different man or woman who the warding off man or woman desires to omit. Maybe anybody instructed the warding off man or woman that the have shyed away from man or woman does not like him/her. But the object is, why do you care? Answered by Eugenie Byrom 2 years ago.

It's an anti-psychotic, for bipolar disorder or schizophrenia. Answered by Pauline Sigmund 2 years ago.


What is Thorazine, Lorazepam and Compazine? What are they used for?
Asked by Catherine Lachowsky 2 years ago.

Chlorpromazine is classified as a low-potency typical antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of bipolar disorder, as well as amphetamine-induced psychoses. Low-potency antipsychotics have more anticholinergic side effects, such as dry mouth, sedation, and constipation, and lower rates of extrapyramidal side effects, while high-potency antipsychotics (such as haloperidol) have the reverse profile. Chlorpromazine has also been used in porphyria and as part of tetanus treatment. It still is recommended for short-term management of severe anxiety and psychotic aggression. Resistant and severe hiccups, severe nausea/emesis, and preanesthetic conditioning are other uses. Symptoms of delirium in medically-hospitalized AIDS patients have been effectively treated with low doses of chlorpromazine Answered by Darwin Napier 2 years ago.

They are antipsycotic drugs used to treat manic depression, schizophrenia Answered by Chas Cichon 2 years ago.


Is 25 mg of Thorazine safe to take for anxiety?
Asked by Rosetta Kozusko 2 years ago.

Thorazine, at 25 mg, is used for chronic hiccups, nausea and vomitting, sedation before surgery, and sometimes anxiety. However, it is anti-psychotic, a tranquilizer, and very old school, so if it was not prescribed to you, don't tske it. This may just be a question of general curiosity, but if you need meds for anxiety, there are more suitable ones than thorazine. See the doc. to get the right one for you! Answered by Jamie Domenick 2 years ago.

Thorazine is not an anti-anxiety drug. It is an antipsychotic drug. Please do not take ANY prescription medication unless under the direction of your personal physician. Answered by Marisol Hoogland 2 years ago.

I think I would speak to a Pharmacist before listening to someone on Yahoo answers. Answered by Tanja Tish 2 years ago.

The potential for causing chronic movement disorders makes it far from ideal. Answered by Eladia Iossa 2 years ago.

It has more potential side effects than newer drugs. For example, seizures, heat exhaustion, drowsiness. Answered by Ula Rashad 2 years ago.


Is it true that Thorazine is as dangerous and the Psychiatric critics say it is?
From Psychiatric critics they criticize Thorazine a lot and say it messes people up like Lobotomy. Here is an example website criticizing Thorazine: http://www.sntp.net/drugs/thorazine.htm Asked by Verda Carthens 2 years ago.

Thorazine is no more dangerous than the others. Staying on it for too long can lead to specific complications, which is true with other anti-psychotics. It isn't used as much these days, but it is still a consideration for some people. It's OK to critisize thorazine, but no more so than for other such drugs. Answered by Laci Salamacha 2 years ago.

Wow! Normally, I don't answer questions that want to learn more and more detail. As in your case, because they require a long process, and it is the risk of not solve all of yours problems. I would suggest to proceed analytically with the help of keywords to be included in Yahoo! From what you climb, narrowing the field with new keywords, until you will be fully satisfied. good luck! Answered by Marianne Youngstrom 2 years ago.


Is Thorazine(Chlorpromazine) an older anti-psychotic?
I was prescribed this recently for Bipolar Disorder. Is it an older anti-psychotic?Thanks Asked by Adaline Pirrello 2 years ago.

Thorazine was one of the first anti-psychotics, created in 1950. It is still occasionally used in the treatment of schizophrenia and bipolar disorder, but not as often as it was a few decades ago. It's a low potency anti-psychotic, so there is a lower chance of experiencing unwanted side effects. Answered by Hertha Feno 2 years ago.


How long will thorazine take to get in my urine stream?
i want to take a thorazine but i have a drug test at 10:00am and dont know what time yo take it so i can pass the drug test and still take it tonight Asked by Harry Lefever 2 years ago.

To my understanding, Thorazine is an anti-psychotic medication. It's not typically screened for on a drug test. However, if you do register with a false positive in another drug category as a result of this medication, all you have to do is show proof of a prescription and you're in the clear. Thorazine is excreted primarily through the urine and has a half-life from 10 to 40 hours. Answered by Kasie Goossens 2 years ago.

You can't wait until after the test to take it - just to be on the safe side? Answered by David Drevs 2 years ago.


About Thorazine/Largactil?
I have read alot about this drug, but I would like to hear from somone that has actually used it, or someone who knows someone who has used it.How sedating/tranquilizing is it? What are the main side-effects, and what pills do I need to counteract these side-effects? Asked by Gene Hegler 2 years ago.

About counteraction - I'm not sure. You'd have to take it to know if you'd have any counteractions, first. I took Thorazine for about a month for sleep. It never made me tired. It would, however, keep me asleep for 8-12 hrs once I laid down and fell asleep. Not a good drug if you need to be knocked out (in my opinion). I'm sure you've heard it called 'the chemical lobotomy'. I didn't feel like it erased too much of my personality, and I was still heavily addicted to drugs and it never made me seek/want drugs less. I really don't remember much from taking it. I snorted it once, and it burned like a SOB, but it knocked me out right away. Answered by Roslyn Jadlowiec 2 years ago.


Mrs S. has been taking Thorazine for about 1 year?
She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the... Asked by Marquita Eckols 2 years ago.

She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the nursing diagnosis for this patient. a) What interventions would be used for this diagnosis? b) How would the nurse evaluate the outcome of the interventions? Answered by Anabel Rovira 2 years ago.

thorazine is bound to have more severe side effects.. clozaril is an atypical antipsychotic drug, so it will be LESS likely to cause tardive dyskenesia and akathisia and other similarly devastating side effects (thanks to its anticholinergic properties). However, there is recent evidence that such drugs may increase the likelihood of metabolic disturbances (leading to diabetes) and cardiovascular disease. There are also sexual functioning side effects, but that is common to many psychotropic meds...Note that slow titration of dosing of Clozaril significantly decreases the likelihood of orthostatic hypotension, so the switch is right on the money for this mrs. s....... I would say the switch from thorazine to clozaril is not a bad idea. I have no idea what you mean by "knowledge deficit" and "nursing diagnosis", I'm coming from a clinical psych perspective, but hope this helps! Answered by Delcie Rueluas 2 years ago.


What is thorazine used for?
Asked by Chang Enstad 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Kallie Knipfel 2 years ago.

Thorazine Uses Answered by Darby Sorrick 2 years ago.

I don't know all of its uses, but I was given Thorazine for migraines. Answered by Guillermina Aspacio 2 years ago.

It is a old anti-psychotic. They use to use it a lot in psychiatric hospitals to calm down patients. It is also used for migraines at times. Answered by Donna Cockrin 2 years ago.

To mess with kids minds! Answered by Madison Birky 2 years ago.

PAIN!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!... Answered by Pei Tease 2 years ago.

Chlorpromazine was the first antipsychotic drug, used during the 1950s and 1960s. Used as chlorpromazine hydrochloride and sold under the tradenames Largactil® and Thorazine®, it has sedative, hypotensive and antiemetic properties as well as anticholinergic and antidopaminergic effects. It has also anxiolytic (alleviation of anxiety) properties. Today, chlorpromazine is considered a typical antipsychotic. Chlorpromazine acts as an antagonist (blocking agent) on different postsynaptic receptors: on dopaminergic-receptors (subtypes D1, D2, D3 and D4, different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), on alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism—controversial), and on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side effects). Additionally, chlorpromazine is a weak presynaptic inhibitor of dopamine reuptake, which may lead to (mild) antidepressive and antiparkinsonian effects. This action could also account for psychomotor agitation and amplification of psychosis (very rarely noted in clinical use). [edit] Peripheral Antagonist to H1 receptors (antiallergic effects), H2 receptors (reduction of forming of gastric juice), M1/M2-receptors (dry mouth, reduction in forming of gastric juice) and some 5-HT receptors (different anti-allergic/gastrointestinal actions). Because it acts on so many receptors, chlorpromazine is often referred to as "dirty drug", whereas the atypical neuroleptic amisulpride for example acts only on central D2/D3-receptors and is therefore a "clean drug". This distinction is not a positive or negative value judgment on the drug, rather it is a neutral term which merely describes the agent's relative pharmacology. [edit] History The drug had been developed by Laboratoires Rhône-Poulenc in 1950 but they sold the rights in 1952 to Smith-Kline & French (today's GlaxoSmithKline). The drug was being sold as an antiemetic when its other use was noted. Smith-Kline was quick to encourage clinical trials and in 1954 the drug was approved in the US for psychiatric treatment. Over 100 million people were treated but the popularity of the drug fell from the late 1960s as the severe extrapyramidal side effects and tardive dyskinesia became more of a concern. From chlorpromazine a number of other similar neuroleptics were developed (e.g. triflupromazine, trifluoperazine). Previously used as an antihistamine and antiemetic its effects on mental state were first reported by the French doctor Henri Laborit in 1951 or 1952 (different sources) as sedation without narcosis. It became possible to cause 'artificial hibernation' in patients, if used as a cocktail together with pethidine and hydergine. Patients with shock, severe trauma or burns, become, if treated so, sedated, without anxiety and unreponsive/indifferent to painful external stimuli like minor surgical interventions. It was first used for psychiatric patients by Pierre Deniker and Jean Delay in 1953. Drug treatment with chlorpromazine went beyond simple sedation with patients showing improvements in thinking and emotional behaviour. Ironically, the antipsychotic properties of chlorpromazine appear to be unrelated to its sedative properties. During long term therapy some tolerance to the sedation effect develops. Chlorpromazine substituted and eclipsed the old therapies of electro- and insulin shocks and other methods such as psychosurgical means (lobotomy) causing permanent brain injury. Chlorpromazine has given approximately 70% of all schizophrenic patients a complete remission or near so and a normal, gainful human life. Before the era of neuroleptics, starting with chlorpromazine, positive long-term results for psychotic patients were only 20%. [edit] Side effects Side effects of chlorpromazine are typical of early generation neuroleptics. They include extrapyramidal side effects such as tardive dyskinesia and akathisia. A particularly severe side effect is the neuroleptic malignant syndrome which occurs in approximately 0.05% and can be fatal. Also, chlorpromazine may lower seizure threshold. Additional side effects include dry mouth, increased appetite with weight gain, constipation and urinary retention. Glucose tolerance may be impaired. An allergic skin rash and photosensitivity may occur. Other important and severe side effects are a strong reduction in the number of white blood cells, referred to as leukopenia, or, in extreme cases, even agranulocytosis may result, which may lead to death via uncontrollable infections and/or sepsis. Chlorpromazine is the neuroleptic drug with the highest rates (0.5% to 1%) of liver toxicity of the cholestatic type. The sedation effect combined with indifference to physical stimuli, anecdotally known as the "thorazine shuffle," has long been associated with the drug. The image of psychiatric patients staggering mute around a padded cell has earned those particular side effects a place in mainstream pop culture. [edit] Interactions Chlorpromazine intensifies the central depressive action of drugs with such activity (tranquilizers, barbiturates, narcotics, antihistamines, OTC-antiemetics etc.). A dose reduction of chlorpromazine or the other drug may be necessary. Chlorpromazine also intensifies the actions and undesired side effects of antihypertensive medications and anticholinergic drugs. The combination of chlorpromazine with other antipsychotics may result in increased central depression, hypotension and extrapyramidal side effects, but may sometimes enhance the clinical results of therapy. The anti-worm drug (antihelminthic) piperazine may intensify extrapyramidal side effects. In general, all neuroleptics may lead to seizures in combination with tramadol (Ultram). Chlorpromazine may increase the insulin needs of diabetic patients. Drugs like SSRIs, St. John's Wort and barbiturates can inhibit various CYP-isoenzymes such as CYP2D6, needed for metabolization of chlorpromazine and/or its metabolites. Theoretically, this should increase the half-lives of chlorpromazine and possibly its metabolites, dosing changes necessary. The exact clinical significance of this enzyme induction and its therapeutic consequences are unknown at present time and remain to be evaluated. [edit] Uses [edit] Common uses [edit] As an antipsychotic The use of chlorpromazine has been primarily replaced by newer generation of atypical antipsychotics which have an improved side effect profile. Chlorpromazine is classified as a low- to moderate-potency antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of manic depression as well as amphetamine-induced psychoses. Chlorpromazine formerly was the drug of choice to treat LSD (and other psychedelic/hallucinogen) intoxication in a hospital setting, resulting in it gaining an erroneous reputation as the LSD "antidote". Now haloperidol is more commonly used in such situations. [edit] Other uses It has also been used in porphyria, as part of tetanus treatment and for behavioral problems in children. It still is well recommended for short term management of severe anxiety and aggressive episodes. Resistant and severe hiccups, severe nausea/emesis and preanesthetic conditioning have been other indications in the past. It can be used to treat amphetamine overdose. [1] [edit] Off-label and controversial uses Chlorpromazine is occasionally used off-label for treatment of severe migraine. Sometimes it is used in small doses to improve nausea/emesis opioid-treated cancer patients encounter and to intensify and prolong the analgesic action of the opioids given. Interestingly, it remains controversial whether or not chlorpromazine has its own analgesic properties. Analgesic properties may result from a central action on the hypothalamus; the patient may feel the pain much less than before. Other mechanisms may be an interaction with opioid receptors centrally and/or in the spinal cord. Some experts on the contrary say that chlorpromazine, like other phenothiazines, may even have antianalgesic properties. Chlorpromazine has been proposed as useful in newborns for the treatment of opioid withdrawal, if the mother was opioid-dependent. The latter indication remains highly controversial. Chlorpromazine, as well as other neuroleptics, may also be used to alleviate the symptoms of alcohol withdrawal (chlorpromazine may lower the seizure-threshold in alcoholics). It has a unique action in cholera, reducing the loss of water by approximately 30%. In Germany, the brand of chlorpromazine drug Propaphenin® has additional indications for insomnia and itching skin disease. [edit] Veterinary uses Chlorpromazine is primarily used as an antiemetic in dogs and cats. It is also sometimes used as a preanesthetic and muscle relaxant in cattle, swine, sheep, and goats. It is generally contraindicated for use with horses, due to a high incidence of ataxia and altered mentation. [edit] Dosage In any case, use is determined by an attending physician. The following information is intended to serve as a guideline: A wide range is covered from 25 mg oral or intramuscular for mild sedation, every 8 hours, up to 100 mg every 6 hours for severely disturbed patients. Different qualified sources give 800 mg/day to 1,200 mg/day as highest dose. At least there is one small clinical trial in treatment-resistant patients with a daily dose of 1,200 mg chlorpromazine (and 4 mg Benztropine to counteract early extrapyramidal side effects, which were anticipated with this unusual high chlorpromazine dose). Initial doses should be low and be increased gradually. It is recommended that most of the daily dose (e.g. 2/3) is given at bedtime for maximum hypnotic activity and minimal daytime sedation and hypotension. In the USA there are controlled release forms of Thorazine (e.g. 300 mg). After the individual dose is well established, such a CR capsule can be given with the evening meal as a single dose, covering the next 24 hours. The lowest dosage compatible with good therapeutic effect should be given. Dosage in ambulatory patients should be particularly low (minimizing sedation and hypotension). The direct i.v.-injection of undiluted solution is contraindicated (massive fall in blood pressure, cardiovascular collapse), for i.v.-infusion of dilutions the (hospitalized) patient should be lying and the infusion rate should be as slow as possible. Afterwards the patient should rest in the lying position for at least 30 minutes. [edit] Necessary examinations and laboratory checks during treatment All patients treated with chlorpromazine on a long-term-basis should have regularly checked their blood-pressure, pulse rate, laboratory-tests (liver function tests, kidney-values, blood cell counts including differenciated white blood counts, counts of red blood cells and thrombocytes), ECG and EEG. The frequency of all checks should be determined for the individual patient and may be done in shorter intervals during the first 3 months of treatment and less often afterwards. Some side effects seem to appear more frequently during the first months of therapy (sedation, hypotension, liver damage) while others do not (e.g. tardive dyskinesia). [edit] Discontinuation of treatment Also, in regular intervals the treating physician should evaluate whether continued treatment is needed. If not, the drug should never be stopped suddenly, due to very unpleasant 'withdrawal-symptoms', such as agitation, sleeplessness, states of anxiety, etc. However, these symptoms definitely do not indicate psychological or physical dependence. The dose should rather be slowly tapered down at a rate of approximately 20–25% per week or even slower to avoid the aforementioned bothersome symptoms. Chlorpromazine is derived from phenothiazine, and has an aliphatic side chain, typical for low to middle potency neuroleptics. The oral bioavailability is estimated to be 30–50% due to extensive first pass metabolization in the liver. Its elimination-halflife is 16–30 hours. It has many active metabolites (approx. 75 different ones) with greatly varying halflives and own pharmacological profiles. The CYP-450 isoenzymes 1A2 and 2D6 are needed for metabolization of chlorpromazine and the subtype 2D6 is inhibited by chlorpromazine (NB: possible interactions with other drugs). Answered by Stefani Dillard 2 years ago.


What are some reasons why a person might be prescribed 200 mg of thorazine?
...from a medical prospective. Asked by Hollie Simoes 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Myrta Kuss 2 years ago.

The warding off man or woman will have angry through a comment the have shyed away from man or woman made. The warding off man or woman will have a few prejudice towards the have shyed away from man or woman. The have shyed away from man or woman might remind the warding off man or woman of an ex-boyfriend or ex-female friend or different man or woman who the warding off man or woman desires to omit. Maybe anybody instructed the warding off man or woman that the have shyed away from man or woman does not like him/her. But the object is, why do you care? Answered by Venetta Caprario 2 years ago.

It's an anti-psychotic, for bipolar disorder or schizophrenia. Answered by Lavenia Montey 2 years ago.


What is Thorazine, Lorazepam and Compazine? What are they used for?
Asked by Lynell Bastine 2 years ago.

Chlorpromazine is classified as a low-potency typical antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of bipolar disorder, as well as amphetamine-induced psychoses. Low-potency antipsychotics have more anticholinergic side effects, such as dry mouth, sedation, and constipation, and lower rates of extrapyramidal side effects, while high-potency antipsychotics (such as haloperidol) have the reverse profile. Chlorpromazine has also been used in porphyria and as part of tetanus treatment. It still is recommended for short-term management of severe anxiety and psychotic aggression. Resistant and severe hiccups, severe nausea/emesis, and preanesthetic conditioning are other uses. Symptoms of delirium in medically-hospitalized AIDS patients have been effectively treated with low doses of chlorpromazine Answered by Ola Crouthamel 2 years ago.

They are antipsycotic drugs used to treat manic depression, schizophrenia Answered by Lasandra Juras 2 years ago.


Is 25 mg of Thorazine safe to take for anxiety?
Asked by Kurtis Aye 2 years ago.

Thorazine, at 25 mg, is used for chronic hiccups, nausea and vomitting, sedation before surgery, and sometimes anxiety. However, it is anti-psychotic, a tranquilizer, and very old school, so if it was not prescribed to you, don't tske it. This may just be a question of general curiosity, but if you need meds for anxiety, there are more suitable ones than thorazine. See the doc. to get the right one for you! Answered by Judie Seigworth 2 years ago.

Thorazine is not an anti-anxiety drug. It is an antipsychotic drug. Please do not take ANY prescription medication unless under the direction of your personal physician. Answered by Polly Pellot 2 years ago.

I think I would speak to a Pharmacist before listening to someone on Yahoo answers. Answered by Jeannette Slentz 2 years ago.

The potential for causing chronic movement disorders makes it far from ideal. Answered by Sigrid Lopze 2 years ago.

It has more potential side effects than newer drugs. For example, seizures, heat exhaustion, drowsiness. Answered by Assunta Kunkel 2 years ago.


Is it true that Thorazine is as dangerous and the Psychiatric critics say it is?
From Psychiatric critics they criticize Thorazine a lot and say it messes people up like Lobotomy. Here is an example website criticizing Thorazine: http://www.sntp.net/drugs/thorazine.htm Asked by Alease Petrocco 2 years ago.

Thorazine is no more dangerous than the others. Staying on it for too long can lead to specific complications, which is true with other anti-psychotics. It isn't used as much these days, but it is still a consideration for some people. It's OK to critisize thorazine, but no more so than for other such drugs. Answered by Joann Iacovetto 2 years ago.

Wow! Normally, I don't answer questions that want to learn more and more detail. As in your case, because they require a long process, and it is the risk of not solve all of yours problems. I would suggest to proceed analytically with the help of keywords to be included in Yahoo! From what you climb, narrowing the field with new keywords, until you will be fully satisfied. good luck! Answered by Daysi Champa 2 years ago.


Is Thorazine(Chlorpromazine) an older anti-psychotic?
I was prescribed this recently for Bipolar Disorder. Is it an older anti-psychotic?Thanks Asked by Altha Ruppert 2 years ago.

Thorazine was one of the first anti-psychotics, created in 1950. It is still occasionally used in the treatment of schizophrenia and bipolar disorder, but not as often as it was a few decades ago. It's a low potency anti-psychotic, so there is a lower chance of experiencing unwanted side effects. Answered by Wonda Fossey 2 years ago.


How long will thorazine take to get in my urine stream?
i want to take a thorazine but i have a drug test at 10:00am and dont know what time yo take it so i can pass the drug test and still take it tonight Asked by Lawanna Simeon 2 years ago.

To my understanding, Thorazine is an anti-psychotic medication. It's not typically screened for on a drug test. However, if you do register with a false positive in another drug category as a result of this medication, all you have to do is show proof of a prescription and you're in the clear. Thorazine is excreted primarily through the urine and has a half-life from 10 to 40 hours. Answered by Vilma Linsin 2 years ago.

You can't wait until after the test to take it - just to be on the safe side? Answered by Carissa Weipert 2 years ago.


About Thorazine/Largactil?
I have read alot about this drug, but I would like to hear from somone that has actually used it, or someone who knows someone who has used it.How sedating/tranquilizing is it? What are the main side-effects, and what pills do I need to counteract these side-effects? Asked by Hilma Bozzo 2 years ago.

About counteraction - I'm not sure. You'd have to take it to know if you'd have any counteractions, first. I took Thorazine for about a month for sleep. It never made me tired. It would, however, keep me asleep for 8-12 hrs once I laid down and fell asleep. Not a good drug if you need to be knocked out (in my opinion). I'm sure you've heard it called 'the chemical lobotomy'. I didn't feel like it erased too much of my personality, and I was still heavily addicted to drugs and it never made me seek/want drugs less. I really don't remember much from taking it. I snorted it once, and it burned like a SOB, but it knocked me out right away. Answered by Modesta Boarts 2 years ago.


Mrs S. has been taking Thorazine for about 1 year?
She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the... Asked by Mia Bilder 2 years ago.

She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the nursing diagnosis for this patient. a) What interventions would be used for this diagnosis? b) How would the nurse evaluate the outcome of the interventions? Answered by Kevin Blomquist 2 years ago.

thorazine is bound to have more severe side effects.. clozaril is an atypical antipsychotic drug, so it will be LESS likely to cause tardive dyskenesia and akathisia and other similarly devastating side effects (thanks to its anticholinergic properties). However, there is recent evidence that such drugs may increase the likelihood of metabolic disturbances (leading to diabetes) and cardiovascular disease. There are also sexual functioning side effects, but that is common to many psychotropic meds...Note that slow titration of dosing of Clozaril significantly decreases the likelihood of orthostatic hypotension, so the switch is right on the money for this mrs. s....... I would say the switch from thorazine to clozaril is not a bad idea. I have no idea what you mean by "knowledge deficit" and "nursing diagnosis", I'm coming from a clinical psych perspective, but hope this helps! Answered by Miss Brotemarkle 2 years ago.


What is thorazine used for?
Asked by Theodore Lindon 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Georgianna Dannard 2 years ago.

Thorazine Uses Answered by Shaunta Robson 2 years ago.

I don't know all of its uses, but I was given Thorazine for migraines. Answered by Sumiko Deschner 2 years ago.

It is a old anti-psychotic. They use to use it a lot in psychiatric hospitals to calm down patients. It is also used for migraines at times. Answered by Jacquline Riche 2 years ago.

To mess with kids minds! Answered by Wendolyn Vilcan 2 years ago.

PAIN!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!... Answered by Verena Napoles 2 years ago.

Chlorpromazine was the first antipsychotic drug, used during the 1950s and 1960s. Used as chlorpromazine hydrochloride and sold under the tradenames Largactil® and Thorazine®, it has sedative, hypotensive and antiemetic properties as well as anticholinergic and antidopaminergic effects. It has also anxiolytic (alleviation of anxiety) properties. Today, chlorpromazine is considered a typical antipsychotic. Chlorpromazine acts as an antagonist (blocking agent) on different postsynaptic receptors: on dopaminergic-receptors (subtypes D1, D2, D3 and D4, different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), on alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism—controversial), and on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side effects). Additionally, chlorpromazine is a weak presynaptic inhibitor of dopamine reuptake, which may lead to (mild) antidepressive and antiparkinsonian effects. This action could also account for psychomotor agitation and amplification of psychosis (very rarely noted in clinical use). [edit] Peripheral Antagonist to H1 receptors (antiallergic effects), H2 receptors (reduction of forming of gastric juice), M1/M2-receptors (dry mouth, reduction in forming of gastric juice) and some 5-HT receptors (different anti-allergic/gastrointestinal actions). Because it acts on so many receptors, chlorpromazine is often referred to as "dirty drug", whereas the atypical neuroleptic amisulpride for example acts only on central D2/D3-receptors and is therefore a "clean drug". This distinction is not a positive or negative value judgment on the drug, rather it is a neutral term which merely describes the agent's relative pharmacology. [edit] History The drug had been developed by Laboratoires Rhône-Poulenc in 1950 but they sold the rights in 1952 to Smith-Kline & French (today's GlaxoSmithKline). The drug was being sold as an antiemetic when its other use was noted. Smith-Kline was quick to encourage clinical trials and in 1954 the drug was approved in the US for psychiatric treatment. Over 100 million people were treated but the popularity of the drug fell from the late 1960s as the severe extrapyramidal side effects and tardive dyskinesia became more of a concern. From chlorpromazine a number of other similar neuroleptics were developed (e.g. triflupromazine, trifluoperazine). Previously used as an antihistamine and antiemetic its effects on mental state were first reported by the French doctor Henri Laborit in 1951 or 1952 (different sources) as sedation without narcosis. It became possible to cause 'artificial hibernation' in patients, if used as a cocktail together with pethidine and hydergine. Patients with shock, severe trauma or burns, become, if treated so, sedated, without anxiety and unreponsive/indifferent to painful external stimuli like minor surgical interventions. It was first used for psychiatric patients by Pierre Deniker and Jean Delay in 1953. Drug treatment with chlorpromazine went beyond simple sedation with patients showing improvements in thinking and emotional behaviour. Ironically, the antipsychotic properties of chlorpromazine appear to be unrelated to its sedative properties. During long term therapy some tolerance to the sedation effect develops. Chlorpromazine substituted and eclipsed the old therapies of electro- and insulin shocks and other methods such as psychosurgical means (lobotomy) causing permanent brain injury. Chlorpromazine has given approximately 70% of all schizophrenic patients a complete remission or near so and a normal, gainful human life. Before the era of neuroleptics, starting with chlorpromazine, positive long-term results for psychotic patients were only 20%. [edit] Side effects Side effects of chlorpromazine are typical of early generation neuroleptics. They include extrapyramidal side effects such as tardive dyskinesia and akathisia. A particularly severe side effect is the neuroleptic malignant syndrome which occurs in approximately 0.05% and can be fatal. Also, chlorpromazine may lower seizure threshold. Additional side effects include dry mouth, increased appetite with weight gain, constipation and urinary retention. Glucose tolerance may be impaired. An allergic skin rash and photosensitivity may occur. Other important and severe side effects are a strong reduction in the number of white blood cells, referred to as leukopenia, or, in extreme cases, even agranulocytosis may result, which may lead to death via uncontrollable infections and/or sepsis. Chlorpromazine is the neuroleptic drug with the highest rates (0.5% to 1%) of liver toxicity of the cholestatic type. The sedation effect combined with indifference to physical stimuli, anecdotally known as the "thorazine shuffle," has long been associated with the drug. The image of psychiatric patients staggering mute around a padded cell has earned those particular side effects a place in mainstream pop culture. [edit] Interactions Chlorpromazine intensifies the central depressive action of drugs with such activity (tranquilizers, barbiturates, narcotics, antihistamines, OTC-antiemetics etc.). A dose reduction of chlorpromazine or the other drug may be necessary. Chlorpromazine also intensifies the actions and undesired side effects of antihypertensive medications and anticholinergic drugs. The combination of chlorpromazine with other antipsychotics may result in increased central depression, hypotension and extrapyramidal side effects, but may sometimes enhance the clinical results of therapy. The anti-worm drug (antihelminthic) piperazine may intensify extrapyramidal side effects. In general, all neuroleptics may lead to seizures in combination with tramadol (Ultram). Chlorpromazine may increase the insulin needs of diabetic patients. Drugs like SSRIs, St. John's Wort and barbiturates can inhibit various CYP-isoenzymes such as CYP2D6, needed for metabolization of chlorpromazine and/or its metabolites. Theoretically, this should increase the half-lives of chlorpromazine and possibly its metabolites, dosing changes necessary. The exact clinical significance of this enzyme induction and its therapeutic consequences are unknown at present time and remain to be evaluated. [edit] Uses [edit] Common uses [edit] As an antipsychotic The use of chlorpromazine has been primarily replaced by newer generation of atypical antipsychotics which have an improved side effect profile. Chlorpromazine is classified as a low- to moderate-potency antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of manic depression as well as amphetamine-induced psychoses. Chlorpromazine formerly was the drug of choice to treat LSD (and other psychedelic/hallucinogen) intoxication in a hospital setting, resulting in it gaining an erroneous reputation as the LSD "antidote". Now haloperidol is more commonly used in such situations. [edit] Other uses It has also been used in porphyria, as part of tetanus treatment and for behavioral problems in children. It still is well recommended for short term management of severe anxiety and aggressive episodes. Resistant and severe hiccups, severe nausea/emesis and preanesthetic conditioning have been other indications in the past. It can be used to treat amphetamine overdose. [1] [edit] Off-label and controversial uses Chlorpromazine is occasionally used off-label for treatment of severe migraine. Sometimes it is used in small doses to improve nausea/emesis opioid-treated cancer patients encounter and to intensify and prolong the analgesic action of the opioids given. Interestingly, it remains controversial whether or not chlorpromazine has its own analgesic properties. Analgesic properties may result from a central action on the hypothalamus; the patient may feel the pain much less than before. Other mechanisms may be an interaction with opioid receptors centrally and/or in the spinal cord. Some experts on the contrary say that chlorpromazine, like other phenothiazines, may even have antianalgesic properties. Chlorpromazine has been proposed as useful in newborns for the treatment of opioid withdrawal, if the mother was opioid-dependent. The latter indication remains highly controversial. Chlorpromazine, as well as other neuroleptics, may also be used to alleviate the symptoms of alcohol withdrawal (chlorpromazine may lower the seizure-threshold in alcoholics). It has a unique action in cholera, reducing the loss of water by approximately 30%. In Germany, the brand of chlorpromazine drug Propaphenin® has additional indications for insomnia and itching skin disease. [edit] Veterinary uses Chlorpromazine is primarily used as an antiemetic in dogs and cats. It is also sometimes used as a preanesthetic and muscle relaxant in cattle, swine, sheep, and goats. It is generally contraindicated for use with horses, due to a high incidence of ataxia and altered mentation. [edit] Dosage In any case, use is determined by an attending physician. The following information is intended to serve as a guideline: A wide range is covered from 25 mg oral or intramuscular for mild sedation, every 8 hours, up to 100 mg every 6 hours for severely disturbed patients. Different qualified sources give 800 mg/day to 1,200 mg/day as highest dose. At least there is one small clinical trial in treatment-resistant patients with a daily dose of 1,200 mg chlorpromazine (and 4 mg Benztropine to counteract early extrapyramidal side effects, which were anticipated with this unusual high chlorpromazine dose). Initial doses should be low and be increased gradually. It is recommended that most of the daily dose (e.g. 2/3) is given at bedtime for maximum hypnotic activity and minimal daytime sedation and hypotension. In the USA there are controlled release forms of Thorazine (e.g. 300 mg). After the individual dose is well established, such a CR capsule can be given with the evening meal as a single dose, covering the next 24 hours. The lowest dosage compatible with good therapeutic effect should be given. Dosage in ambulatory patients should be particularly low (minimizing sedation and hypotension). The direct i.v.-injection of undiluted solution is contraindicated (massive fall in blood pressure, cardiovascular collapse), for i.v.-infusion of dilutions the (hospitalized) patient should be lying and the infusion rate should be as slow as possible. Afterwards the patient should rest in the lying position for at least 30 minutes. [edit] Necessary examinations and laboratory checks during treatment All patients treated with chlorpromazine on a long-term-basis should have regularly checked their blood-pressure, pulse rate, laboratory-tests (liver function tests, kidney-values, blood cell counts including differenciated white blood counts, counts of red blood cells and thrombocytes), ECG and EEG. The frequency of all checks should be determined for the individual patient and may be done in shorter intervals during the first 3 months of treatment and less often afterwards. Some side effects seem to appear more frequently during the first months of therapy (sedation, hypotension, liver damage) while others do not (e.g. tardive dyskinesia). [edit] Discontinuation of treatment Also, in regular intervals the treating physician should evaluate whether continued treatment is needed. If not, the drug should never be stopped suddenly, due to very unpleasant 'withdrawal-symptoms', such as agitation, sleeplessness, states of anxiety, etc. However, these symptoms definitely do not indicate psychological or physical dependence. The dose should rather be slowly tapered down at a rate of approximately 20–25% per week or even slower to avoid the aforementioned bothersome symptoms. Chlorpromazine is derived from phenothiazine, and has an aliphatic side chain, typical for low to middle potency neuroleptics. The oral bioavailability is estimated to be 30–50% due to extensive first pass metabolization in the liver. Its elimination-halflife is 16–30 hours. It has many active metabolites (approx. 75 different ones) with greatly varying halflives and own pharmacological profiles. The CYP-450 isoenzymes 1A2 and 2D6 are needed for metabolization of chlorpromazine and the subtype 2D6 is inhibited by chlorpromazine (NB: possible interactions with other drugs). Answered by Bethany Alvara 2 years ago.


What are some reasons why a person might be prescribed 200 mg of thorazine?
...from a medical prospective. Asked by Nolan Boehlar 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Andy Demilt 2 years ago.

The warding off man or woman will have angry through a comment the have shyed away from man or woman made. The warding off man or woman will have a few prejudice towards the have shyed away from man or woman. The have shyed away from man or woman might remind the warding off man or woman of an ex-boyfriend or ex-female friend or different man or woman who the warding off man or woman desires to omit. Maybe anybody instructed the warding off man or woman that the have shyed away from man or woman does not like him/her. But the object is, why do you care? Answered by Tonya Theil 2 years ago.

It's an anti-psychotic, for bipolar disorder or schizophrenia. Answered by Gerry Dorries 2 years ago.


What is Thorazine, Lorazepam and Compazine? What are they used for?
Asked by Lashaun Guilfoos 2 years ago.

Chlorpromazine is classified as a low-potency typical antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of bipolar disorder, as well as amphetamine-induced psychoses. Low-potency antipsychotics have more anticholinergic side effects, such as dry mouth, sedation, and constipation, and lower rates of extrapyramidal side effects, while high-potency antipsychotics (such as haloperidol) have the reverse profile. Chlorpromazine has also been used in porphyria and as part of tetanus treatment. It still is recommended for short-term management of severe anxiety and psychotic aggression. Resistant and severe hiccups, severe nausea/emesis, and preanesthetic conditioning are other uses. Symptoms of delirium in medically-hospitalized AIDS patients have been effectively treated with low doses of chlorpromazine Answered by Tomasa Wingenter 2 years ago.

They are antipsycotic drugs used to treat manic depression, schizophrenia Answered by Alisa Heimark 2 years ago.


Is 25 mg of Thorazine safe to take for anxiety?
Asked by Deja Niblett 2 years ago.

Thorazine, at 25 mg, is used for chronic hiccups, nausea and vomitting, sedation before surgery, and sometimes anxiety. However, it is anti-psychotic, a tranquilizer, and very old school, so if it was not prescribed to you, don't tske it. This may just be a question of general curiosity, but if you need meds for anxiety, there are more suitable ones than thorazine. See the doc. to get the right one for you! Answered by Tiffani Galustian 2 years ago.

Thorazine is not an anti-anxiety drug. It is an antipsychotic drug. Please do not take ANY prescription medication unless under the direction of your personal physician. Answered by Hyun Holifield 2 years ago.

I think I would speak to a Pharmacist before listening to someone on Yahoo answers. Answered by Veta Gazaille 2 years ago.

The potential for causing chronic movement disorders makes it far from ideal. Answered by Madison Gutknecht 2 years ago.

It has more potential side effects than newer drugs. For example, seizures, heat exhaustion, drowsiness. Answered by Hilaria Flemmon 2 years ago.


Is it true that Thorazine is as dangerous and the Psychiatric critics say it is?
From Psychiatric critics they criticize Thorazine a lot and say it messes people up like Lobotomy. Here is an example website criticizing Thorazine: http://www.sntp.net/drugs/thorazine.htm Asked by Bebe Garon 2 years ago.

Thorazine is no more dangerous than the others. Staying on it for too long can lead to specific complications, which is true with other anti-psychotics. It isn't used as much these days, but it is still a consideration for some people. It's OK to critisize thorazine, but no more so than for other such drugs. Answered by Edwardo Hallinan 2 years ago.

Wow! Normally, I don't answer questions that want to learn more and more detail. As in your case, because they require a long process, and it is the risk of not solve all of yours problems. I would suggest to proceed analytically with the help of keywords to be included in Yahoo! From what you climb, narrowing the field with new keywords, until you will be fully satisfied. good luck! Answered by Aron Flott 2 years ago.


Is Thorazine(Chlorpromazine) an older anti-psychotic?
I was prescribed this recently for Bipolar Disorder. Is it an older anti-psychotic?Thanks Asked by Laurel Sampaga 2 years ago.

Thorazine was one of the first anti-psychotics, created in 1950. It is still occasionally used in the treatment of schizophrenia and bipolar disorder, but not as often as it was a few decades ago. It's a low potency anti-psychotic, so there is a lower chance of experiencing unwanted side effects. Answered by Shaquita Stefanich 2 years ago.


How long will thorazine take to get in my urine stream?
i want to take a thorazine but i have a drug test at 10:00am and dont know what time yo take it so i can pass the drug test and still take it tonight Asked by Bret Repko 2 years ago.

To my understanding, Thorazine is an anti-psychotic medication. It's not typically screened for on a drug test. However, if you do register with a false positive in another drug category as a result of this medication, all you have to do is show proof of a prescription and you're in the clear. Thorazine is excreted primarily through the urine and has a half-life from 10 to 40 hours. Answered by Steffanie Clos 2 years ago.

You can't wait until after the test to take it - just to be on the safe side? Answered by Demetrice Buttray 2 years ago.


About Thorazine/Largactil?
I have read alot about this drug, but I would like to hear from somone that has actually used it, or someone who knows someone who has used it.How sedating/tranquilizing is it? What are the main side-effects, and what pills do I need to counteract these side-effects? Asked by Zina Roop 2 years ago.

About counteraction - I'm not sure. You'd have to take it to know if you'd have any counteractions, first. I took Thorazine for about a month for sleep. It never made me tired. It would, however, keep me asleep for 8-12 hrs once I laid down and fell asleep. Not a good drug if you need to be knocked out (in my opinion). I'm sure you've heard it called 'the chemical lobotomy'. I didn't feel like it erased too much of my personality, and I was still heavily addicted to drugs and it never made me seek/want drugs less. I really don't remember much from taking it. I snorted it once, and it burned like a SOB, but it knocked me out right away. Answered by Nettie Pase 2 years ago.


Mrs S. has been taking Thorazine for about 1 year?
She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the... Asked by Alline Arent 2 years ago.

She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the nursing diagnosis for this patient. a) What interventions would be used for this diagnosis? b) How would the nurse evaluate the outcome of the interventions? Answered by Meda Micciche 2 years ago.

thorazine is bound to have more severe side effects.. clozaril is an atypical antipsychotic drug, so it will be LESS likely to cause tardive dyskenesia and akathisia and other similarly devastating side effects (thanks to its anticholinergic properties). However, there is recent evidence that such drugs may increase the likelihood of metabolic disturbances (leading to diabetes) and cardiovascular disease. There are also sexual functioning side effects, but that is common to many psychotropic meds...Note that slow titration of dosing of Clozaril significantly decreases the likelihood of orthostatic hypotension, so the switch is right on the money for this mrs. s....... I would say the switch from thorazine to clozaril is not a bad idea. I have no idea what you mean by "knowledge deficit" and "nursing diagnosis", I'm coming from a clinical psych perspective, but hope this helps! Answered by Miranda Casto 2 years ago.


What is thorazine used for?
Asked by Izola Lightcap 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Randi Efrati 2 years ago.

Thorazine Uses Answered by See Habash 2 years ago.

I don't know all of its uses, but I was given Thorazine for migraines. Answered by Dotty Manzay 2 years ago.

It is a old anti-psychotic. They use to use it a lot in psychiatric hospitals to calm down patients. It is also used for migraines at times. Answered by Waylon Reulet 2 years ago.

To mess with kids minds! Answered by Frank Catalli 2 years ago.

PAIN!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!... Answered by Antonina Stodghill 2 years ago.

Chlorpromazine was the first antipsychotic drug, used during the 1950s and 1960s. Used as chlorpromazine hydrochloride and sold under the tradenames Largactil® and Thorazine®, it has sedative, hypotensive and antiemetic properties as well as anticholinergic and antidopaminergic effects. It has also anxiolytic (alleviation of anxiety) properties. Today, chlorpromazine is considered a typical antipsychotic. Chlorpromazine acts as an antagonist (blocking agent) on different postsynaptic receptors: on dopaminergic-receptors (subtypes D1, D2, D3 and D4, different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), on alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism—controversial), and on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side effects). Additionally, chlorpromazine is a weak presynaptic inhibitor of dopamine reuptake, which may lead to (mild) antidepressive and antiparkinsonian effects. This action could also account for psychomotor agitation and amplification of psychosis (very rarely noted in clinical use). [edit] Peripheral Antagonist to H1 receptors (antiallergic effects), H2 receptors (reduction of forming of gastric juice), M1/M2-receptors (dry mouth, reduction in forming of gastric juice) and some 5-HT receptors (different anti-allergic/gastrointestinal actions). Because it acts on so many receptors, chlorpromazine is often referred to as "dirty drug", whereas the atypical neuroleptic amisulpride for example acts only on central D2/D3-receptors and is therefore a "clean drug". This distinction is not a positive or negative value judgment on the drug, rather it is a neutral term which merely describes the agent's relative pharmacology. [edit] History The drug had been developed by Laboratoires Rhône-Poulenc in 1950 but they sold the rights in 1952 to Smith-Kline & French (today's GlaxoSmithKline). The drug was being sold as an antiemetic when its other use was noted. Smith-Kline was quick to encourage clinical trials and in 1954 the drug was approved in the US for psychiatric treatment. Over 100 million people were treated but the popularity of the drug fell from the late 1960s as the severe extrapyramidal side effects and tardive dyskinesia became more of a concern. From chlorpromazine a number of other similar neuroleptics were developed (e.g. triflupromazine, trifluoperazine). Previously used as an antihistamine and antiemetic its effects on mental state were first reported by the French doctor Henri Laborit in 1951 or 1952 (different sources) as sedation without narcosis. It became possible to cause 'artificial hibernation' in patients, if used as a cocktail together with pethidine and hydergine. Patients with shock, severe trauma or burns, become, if treated so, sedated, without anxiety and unreponsive/indifferent to painful external stimuli like minor surgical interventions. It was first used for psychiatric patients by Pierre Deniker and Jean Delay in 1953. Drug treatment with chlorpromazine went beyond simple sedation with patients showing improvements in thinking and emotional behaviour. Ironically, the antipsychotic properties of chlorpromazine appear to be unrelated to its sedative properties. During long term therapy some tolerance to the sedation effect develops. Chlorpromazine substituted and eclipsed the old therapies of electro- and insulin shocks and other methods such as psychosurgical means (lobotomy) causing permanent brain injury. Chlorpromazine has given approximately 70% of all schizophrenic patients a complete remission or near so and a normal, gainful human life. Before the era of neuroleptics, starting with chlorpromazine, positive long-term results for psychotic patients were only 20%. [edit] Side effects Side effects of chlorpromazine are typical of early generation neuroleptics. They include extrapyramidal side effects such as tardive dyskinesia and akathisia. A particularly severe side effect is the neuroleptic malignant syndrome which occurs in approximately 0.05% and can be fatal. Also, chlorpromazine may lower seizure threshold. Additional side effects include dry mouth, increased appetite with weight gain, constipation and urinary retention. Glucose tolerance may be impaired. An allergic skin rash and photosensitivity may occur. Other important and severe side effects are a strong reduction in the number of white blood cells, referred to as leukopenia, or, in extreme cases, even agranulocytosis may result, which may lead to death via uncontrollable infections and/or sepsis. Chlorpromazine is the neuroleptic drug with the highest rates (0.5% to 1%) of liver toxicity of the cholestatic type. The sedation effect combined with indifference to physical stimuli, anecdotally known as the "thorazine shuffle," has long been associated with the drug. The image of psychiatric patients staggering mute around a padded cell has earned those particular side effects a place in mainstream pop culture. [edit] Interactions Chlorpromazine intensifies the central depressive action of drugs with such activity (tranquilizers, barbiturates, narcotics, antihistamines, OTC-antiemetics etc.). A dose reduction of chlorpromazine or the other drug may be necessary. Chlorpromazine also intensifies the actions and undesired side effects of antihypertensive medications and anticholinergic drugs. The combination of chlorpromazine with other antipsychotics may result in increased central depression, hypotension and extrapyramidal side effects, but may sometimes enhance the clinical results of therapy. The anti-worm drug (antihelminthic) piperazine may intensify extrapyramidal side effects. In general, all neuroleptics may lead to seizures in combination with tramadol (Ultram). Chlorpromazine may increase the insulin needs of diabetic patients. Drugs like SSRIs, St. John's Wort and barbiturates can inhibit various CYP-isoenzymes such as CYP2D6, needed for metabolization of chlorpromazine and/or its metabolites. Theoretically, this should increase the half-lives of chlorpromazine and possibly its metabolites, dosing changes necessary. The exact clinical significance of this enzyme induction and its therapeutic consequences are unknown at present time and remain to be evaluated. [edit] Uses [edit] Common uses [edit] As an antipsychotic The use of chlorpromazine has been primarily replaced by newer generation of atypical antipsychotics which have an improved side effect profile. Chlorpromazine is classified as a low- to moderate-potency antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of manic depression as well as amphetamine-induced psychoses. Chlorpromazine formerly was the drug of choice to treat LSD (and other psychedelic/hallucinogen) intoxication in a hospital setting, resulting in it gaining an erroneous reputation as the LSD "antidote". Now haloperidol is more commonly used in such situations. [edit] Other uses It has also been used in porphyria, as part of tetanus treatment and for behavioral problems in children. It still is well recommended for short term management of severe anxiety and aggressive episodes. Resistant and severe hiccups, severe nausea/emesis and preanesthetic conditioning have been other indications in the past. It can be used to treat amphetamine overdose. [1] [edit] Off-label and controversial uses Chlorpromazine is occasionally used off-label for treatment of severe migraine. Sometimes it is used in small doses to improve nausea/emesis opioid-treated cancer patients encounter and to intensify and prolong the analgesic action of the opioids given. Interestingly, it remains controversial whether or not chlorpromazine has its own analgesic properties. Analgesic properties may result from a central action on the hypothalamus; the patient may feel the pain much less than before. Other mechanisms may be an interaction with opioid receptors centrally and/or in the spinal cord. Some experts on the contrary say that chlorpromazine, like other phenothiazines, may even have antianalgesic properties. Chlorpromazine has been proposed as useful in newborns for the treatment of opioid withdrawal, if the mother was opioid-dependent. The latter indication remains highly controversial. Chlorpromazine, as well as other neuroleptics, may also be used to alleviate the symptoms of alcohol withdrawal (chlorpromazine may lower the seizure-threshold in alcoholics). It has a unique action in cholera, reducing the loss of water by approximately 30%. In Germany, the brand of chlorpromazine drug Propaphenin® has additional indications for insomnia and itching skin disease. [edit] Veterinary uses Chlorpromazine is primarily used as an antiemetic in dogs and cats. It is also sometimes used as a preanesthetic and muscle relaxant in cattle, swine, sheep, and goats. It is generally contraindicated for use with horses, due to a high incidence of ataxia and altered mentation. [edit] Dosage In any case, use is determined by an attending physician. The following information is intended to serve as a guideline: A wide range is covered from 25 mg oral or intramuscular for mild sedation, every 8 hours, up to 100 mg every 6 hours for severely disturbed patients. Different qualified sources give 800 mg/day to 1,200 mg/day as highest dose. At least there is one small clinical trial in treatment-resistant patients with a daily dose of 1,200 mg chlorpromazine (and 4 mg Benztropine to counteract early extrapyramidal side effects, which were anticipated with this unusual high chlorpromazine dose). Initial doses should be low and be increased gradually. It is recommended that most of the daily dose (e.g. 2/3) is given at bedtime for maximum hypnotic activity and minimal daytime sedation and hypotension. In the USA there are controlled release forms of Thorazine (e.g. 300 mg). After the individual dose is well established, such a CR capsule can be given with the evening meal as a single dose, covering the next 24 hours. The lowest dosage compatible with good therapeutic effect should be given. Dosage in ambulatory patients should be particularly low (minimizing sedation and hypotension). The direct i.v.-injection of undiluted solution is contraindicated (massive fall in blood pressure, cardiovascular collapse), for i.v.-infusion of dilutions the (hospitalized) patient should be lying and the infusion rate should be as slow as possible. Afterwards the patient should rest in the lying position for at least 30 minutes. [edit] Necessary examinations and laboratory checks during treatment All patients treated with chlorpromazine on a long-term-basis should have regularly checked their blood-pressure, pulse rate, laboratory-tests (liver function tests, kidney-values, blood cell counts including differenciated white blood counts, counts of red blood cells and thrombocytes), ECG and EEG. The frequency of all checks should be determined for the individual patient and may be done in shorter intervals during the first 3 months of treatment and less often afterwards. Some side effects seem to appear more frequently during the first months of therapy (sedation, hypotension, liver damage) while others do not (e.g. tardive dyskinesia). [edit] Discontinuation of treatment Also, in regular intervals the treating physician should evaluate whether continued treatment is needed. If not, the drug should never be stopped suddenly, due to very unpleasant 'withdrawal-symptoms', such as agitation, sleeplessness, states of anxiety, etc. However, these symptoms definitely do not indicate psychological or physical dependence. The dose should rather be slowly tapered down at a rate of approximately 20–25% per week or even slower to avoid the aforementioned bothersome symptoms. Chlorpromazine is derived from phenothiazine, and has an aliphatic side chain, typical for low to middle potency neuroleptics. The oral bioavailability is estimated to be 30–50% due to extensive first pass metabolization in the liver. Its elimination-halflife is 16–30 hours. It has many active metabolites (approx. 75 different ones) with greatly varying halflives and own pharmacological profiles. The CYP-450 isoenzymes 1A2 and 2D6 are needed for metabolization of chlorpromazine and the subtype 2D6 is inhibited by chlorpromazine (NB: possible interactions with other drugs). Answered by August Stick 2 years ago.


What are some reasons why a person might be prescribed 200 mg of thorazine?
...from a medical prospective. Asked by Verona Sookoo 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Love Delenick 2 years ago.

The warding off man or woman will have angry through a comment the have shyed away from man or woman made. The warding off man or woman will have a few prejudice towards the have shyed away from man or woman. The have shyed away from man or woman might remind the warding off man or woman of an ex-boyfriend or ex-female friend or different man or woman who the warding off man or woman desires to omit. Maybe anybody instructed the warding off man or woman that the have shyed away from man or woman does not like him/her. But the object is, why do you care? Answered by Leona Dottin 2 years ago.

It's an anti-psychotic, for bipolar disorder or schizophrenia. Answered by Moon Akhavan 2 years ago.


What is Thorazine, Lorazepam and Compazine? What are they used for?
Asked by Leanora Hinchliffe 2 years ago.

Chlorpromazine is classified as a low-potency typical antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of bipolar disorder, as well as amphetamine-induced psychoses. Low-potency antipsychotics have more anticholinergic side effects, such as dry mouth, sedation, and constipation, and lower rates of extrapyramidal side effects, while high-potency antipsychotics (such as haloperidol) have the reverse profile. Chlorpromazine has also been used in porphyria and as part of tetanus treatment. It still is recommended for short-term management of severe anxiety and psychotic aggression. Resistant and severe hiccups, severe nausea/emesis, and preanesthetic conditioning are other uses. Symptoms of delirium in medically-hospitalized AIDS patients have been effectively treated with low doses of chlorpromazine Answered by Vicky Bossley 2 years ago.

They are antipsycotic drugs used to treat manic depression, schizophrenia Answered by Benton Berlandy 2 years ago.


Is 25 mg of Thorazine safe to take for anxiety?
Asked by Loreta Satmary 2 years ago.

Thorazine, at 25 mg, is used for chronic hiccups, nausea and vomitting, sedation before surgery, and sometimes anxiety. However, it is anti-psychotic, a tranquilizer, and very old school, so if it was not prescribed to you, don't tske it. This may just be a question of general curiosity, but if you need meds for anxiety, there are more suitable ones than thorazine. See the doc. to get the right one for you! Answered by Mariano Keehan 2 years ago.

Thorazine is not an anti-anxiety drug. It is an antipsychotic drug. Please do not take ANY prescription medication unless under the direction of your personal physician. Answered by Ines Liccione 2 years ago.

I think I would speak to a Pharmacist before listening to someone on Yahoo answers. Answered by Terry Vandersteen 2 years ago.

The potential for causing chronic movement disorders makes it far from ideal. Answered by Alysha Lieu 2 years ago.

It has more potential side effects than newer drugs. For example, seizures, heat exhaustion, drowsiness. Answered by Erinn Bobrow 2 years ago.


Is it true that Thorazine is as dangerous and the Psychiatric critics say it is?
From Psychiatric critics they criticize Thorazine a lot and say it messes people up like Lobotomy. Here is an example website criticizing Thorazine: http://www.sntp.net/drugs/thorazine.htm Asked by Kirstie Schear 2 years ago.

Thorazine is no more dangerous than the others. Staying on it for too long can lead to specific complications, which is true with other anti-psychotics. It isn't used as much these days, but it is still a consideration for some people. It's OK to critisize thorazine, but no more so than for other such drugs. Answered by Casandra Restivo 2 years ago.

Wow! Normally, I don't answer questions that want to learn more and more detail. As in your case, because they require a long process, and it is the risk of not solve all of yours problems. I would suggest to proceed analytically with the help of keywords to be included in Yahoo! From what you climb, narrowing the field with new keywords, until you will be fully satisfied. good luck! Answered by Anjanette Plumbar 2 years ago.


Is Thorazine(Chlorpromazine) an older anti-psychotic?
I was prescribed this recently for Bipolar Disorder. Is it an older anti-psychotic?Thanks Asked by Bernard Woolum 2 years ago.

Thorazine was one of the first anti-psychotics, created in 1950. It is still occasionally used in the treatment of schizophrenia and bipolar disorder, but not as often as it was a few decades ago. It's a low potency anti-psychotic, so there is a lower chance of experiencing unwanted side effects. Answered by Normand Gossi 2 years ago.


How long will thorazine take to get in my urine stream?
i want to take a thorazine but i have a drug test at 10:00am and dont know what time yo take it so i can pass the drug test and still take it tonight Asked by Yesenia Gean 2 years ago.

To my understanding, Thorazine is an anti-psychotic medication. It's not typically screened for on a drug test. However, if you do register with a false positive in another drug category as a result of this medication, all you have to do is show proof of a prescription and you're in the clear. Thorazine is excreted primarily through the urine and has a half-life from 10 to 40 hours. Answered by Eun Hartsell 2 years ago.

You can't wait until after the test to take it - just to be on the safe side? Answered by Horace Finkler 2 years ago.


About Thorazine/Largactil?
I have read alot about this drug, but I would like to hear from somone that has actually used it, or someone who knows someone who has used it.How sedating/tranquilizing is it? What are the main side-effects, and what pills do I need to counteract these side-effects? Asked by Sana Towse 2 years ago.

About counteraction - I'm not sure. You'd have to take it to know if you'd have any counteractions, first. I took Thorazine for about a month for sleep. It never made me tired. It would, however, keep me asleep for 8-12 hrs once I laid down and fell asleep. Not a good drug if you need to be knocked out (in my opinion). I'm sure you've heard it called 'the chemical lobotomy'. I didn't feel like it erased too much of my personality, and I was still heavily addicted to drugs and it never made me seek/want drugs less. I really don't remember much from taking it. I snorted it once, and it burned like a SOB, but it knocked me out right away. Answered by Sandee Herbers 2 years ago.


Mrs S. has been taking Thorazine for about 1 year?
She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the... Asked by Elene Arichabala 2 years ago.

She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the nursing diagnosis for this patient. a) What interventions would be used for this diagnosis? b) How would the nurse evaluate the outcome of the interventions? Answered by Sylvia Narum 2 years ago.

thorazine is bound to have more severe side effects.. clozaril is an atypical antipsychotic drug, so it will be LESS likely to cause tardive dyskenesia and akathisia and other similarly devastating side effects (thanks to its anticholinergic properties). However, there is recent evidence that such drugs may increase the likelihood of metabolic disturbances (leading to diabetes) and cardiovascular disease. There are also sexual functioning side effects, but that is common to many psychotropic meds...Note that slow titration of dosing of Clozaril significantly decreases the likelihood of orthostatic hypotension, so the switch is right on the money for this mrs. s....... I would say the switch from thorazine to clozaril is not a bad idea. I have no idea what you mean by "knowledge deficit" and "nursing diagnosis", I'm coming from a clinical psych perspective, but hope this helps! Answered by Glennie Quail 2 years ago.


What is thorazine used for?
Asked by Hunter Leventer 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Nelda Howard 2 years ago.

Thorazine Uses Answered by Barabara Hobden 2 years ago.

I don't know all of its uses, but I was given Thorazine for migraines. Answered by Virgina Daughtrey 2 years ago.

It is a old anti-psychotic. They use to use it a lot in psychiatric hospitals to calm down patients. It is also used for migraines at times. Answered by Trudy Bela 2 years ago.

To mess with kids minds! Answered by Morton Wucherer 2 years ago.

PAIN!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!... Answered by Curtis Seirer 2 years ago.

Chlorpromazine was the first antipsychotic drug, used during the 1950s and 1960s. Used as chlorpromazine hydrochloride and sold under the tradenames Largactil® and Thorazine®, it has sedative, hypotensive and antiemetic properties as well as anticholinergic and antidopaminergic effects. It has also anxiolytic (alleviation of anxiety) properties. Today, chlorpromazine is considered a typical antipsychotic. Chlorpromazine acts as an antagonist (blocking agent) on different postsynaptic receptors: on dopaminergic-receptors (subtypes D1, D2, D3 and D4, different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), on alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism—controversial), and on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side effects). Additionally, chlorpromazine is a weak presynaptic inhibitor of dopamine reuptake, which may lead to (mild) antidepressive and antiparkinsonian effects. This action could also account for psychomotor agitation and amplification of psychosis (very rarely noted in clinical use). [edit] Peripheral Antagonist to H1 receptors (antiallergic effects), H2 receptors (reduction of forming of gastric juice), M1/M2-receptors (dry mouth, reduction in forming of gastric juice) and some 5-HT receptors (different anti-allergic/gastrointestinal actions). Because it acts on so many receptors, chlorpromazine is often referred to as "dirty drug", whereas the atypical neuroleptic amisulpride for example acts only on central D2/D3-receptors and is therefore a "clean drug". This distinction is not a positive or negative value judgment on the drug, rather it is a neutral term which merely describes the agent's relative pharmacology. [edit] History The drug had been developed by Laboratoires Rhône-Poulenc in 1950 but they sold the rights in 1952 to Smith-Kline & French (today's GlaxoSmithKline). The drug was being sold as an antiemetic when its other use was noted. Smith-Kline was quick to encourage clinical trials and in 1954 the drug was approved in the US for psychiatric treatment. Over 100 million people were treated but the popularity of the drug fell from the late 1960s as the severe extrapyramidal side effects and tardive dyskinesia became more of a concern. From chlorpromazine a number of other similar neuroleptics were developed (e.g. triflupromazine, trifluoperazine). Previously used as an antihistamine and antiemetic its effects on mental state were first reported by the French doctor Henri Laborit in 1951 or 1952 (different sources) as sedation without narcosis. It became possible to cause 'artificial hibernation' in patients, if used as a cocktail together with pethidine and hydergine. Patients with shock, severe trauma or burns, become, if treated so, sedated, without anxiety and unreponsive/indifferent to painful external stimuli like minor surgical interventions. It was first used for psychiatric patients by Pierre Deniker and Jean Delay in 1953. Drug treatment with chlorpromazine went beyond simple sedation with patients showing improvements in thinking and emotional behaviour. Ironically, the antipsychotic properties of chlorpromazine appear to be unrelated to its sedative properties. During long term therapy some tolerance to the sedation effect develops. Chlorpromazine substituted and eclipsed the old therapies of electro- and insulin shocks and other methods such as psychosurgical means (lobotomy) causing permanent brain injury. Chlorpromazine has given approximately 70% of all schizophrenic patients a complete remission or near so and a normal, gainful human life. Before the era of neuroleptics, starting with chlorpromazine, positive long-term results for psychotic patients were only 20%. [edit] Side effects Side effects of chlorpromazine are typical of early generation neuroleptics. They include extrapyramidal side effects such as tardive dyskinesia and akathisia. A particularly severe side effect is the neuroleptic malignant syndrome which occurs in approximately 0.05% and can be fatal. Also, chlorpromazine may lower seizure threshold. Additional side effects include dry mouth, increased appetite with weight gain, constipation and urinary retention. Glucose tolerance may be impaired. An allergic skin rash and photosensitivity may occur. Other important and severe side effects are a strong reduction in the number of white blood cells, referred to as leukopenia, or, in extreme cases, even agranulocytosis may result, which may lead to death via uncontrollable infections and/or sepsis. Chlorpromazine is the neuroleptic drug with the highest rates (0.5% to 1%) of liver toxicity of the cholestatic type. The sedation effect combined with indifference to physical stimuli, anecdotally known as the "thorazine shuffle," has long been associated with the drug. The image of psychiatric patients staggering mute around a padded cell has earned those particular side effects a place in mainstream pop culture. [edit] Interactions Chlorpromazine intensifies the central depressive action of drugs with such activity (tranquilizers, barbiturates, narcotics, antihistamines, OTC-antiemetics etc.). A dose reduction of chlorpromazine or the other drug may be necessary. Chlorpromazine also intensifies the actions and undesired side effects of antihypertensive medications and anticholinergic drugs. The combination of chlorpromazine with other antipsychotics may result in increased central depression, hypotension and extrapyramidal side effects, but may sometimes enhance the clinical results of therapy. The anti-worm drug (antihelminthic) piperazine may intensify extrapyramidal side effects. In general, all neuroleptics may lead to seizures in combination with tramadol (Ultram). Chlorpromazine may increase the insulin needs of diabetic patients. Drugs like SSRIs, St. John's Wort and barbiturates can inhibit various CYP-isoenzymes such as CYP2D6, needed for metabolization of chlorpromazine and/or its metabolites. Theoretically, this should increase the half-lives of chlorpromazine and possibly its metabolites, dosing changes necessary. The exact clinical significance of this enzyme induction and its therapeutic consequences are unknown at present time and remain to be evaluated. [edit] Uses [edit] Common uses [edit] As an antipsychotic The use of chlorpromazine has been primarily replaced by newer generation of atypical antipsychotics which have an improved side effect profile. Chlorpromazine is classified as a low- to moderate-potency antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of manic depression as well as amphetamine-induced psychoses. Chlorpromazine formerly was the drug of choice to treat LSD (and other psychedelic/hallucinogen) intoxication in a hospital setting, resulting in it gaining an erroneous reputation as the LSD "antidote". Now haloperidol is more commonly used in such situations. [edit] Other uses It has also been used in porphyria, as part of tetanus treatment and for behavioral problems in children. It still is well recommended for short term management of severe anxiety and aggressive episodes. Resistant and severe hiccups, severe nausea/emesis and preanesthetic conditioning have been other indications in the past. It can be used to treat amphetamine overdose. [1] [edit] Off-label and controversial uses Chlorpromazine is occasionally used off-label for treatment of severe migraine. Sometimes it is used in small doses to improve nausea/emesis opioid-treated cancer patients encounter and to intensify and prolong the analgesic action of the opioids given. Interestingly, it remains controversial whether or not chlorpromazine has its own analgesic properties. Analgesic properties may result from a central action on the hypothalamus; the patient may feel the pain much less than before. Other mechanisms may be an interaction with opioid receptors centrally and/or in the spinal cord. Some experts on the contrary say that chlorpromazine, like other phenothiazines, may even have antianalgesic properties. Chlorpromazine has been proposed as useful in newborns for the treatment of opioid withdrawal, if the mother was opioid-dependent. The latter indication remains highly controversial. Chlorpromazine, as well as other neuroleptics, may also be used to alleviate the symptoms of alcohol withdrawal (chlorpromazine may lower the seizure-threshold in alcoholics). It has a unique action in cholera, reducing the loss of water by approximately 30%. In Germany, the brand of chlorpromazine drug Propaphenin® has additional indications for insomnia and itching skin disease. [edit] Veterinary uses Chlorpromazine is primarily used as an antiemetic in dogs and cats. It is also sometimes used as a preanesthetic and muscle relaxant in cattle, swine, sheep, and goats. It is generally contraindicated for use with horses, due to a high incidence of ataxia and altered mentation. [edit] Dosage In any case, use is determined by an attending physician. The following information is intended to serve as a guideline: A wide range is covered from 25 mg oral or intramuscular for mild sedation, every 8 hours, up to 100 mg every 6 hours for severely disturbed patients. Different qualified sources give 800 mg/day to 1,200 mg/day as highest dose. At least there is one small clinical trial in treatment-resistant patients with a daily dose of 1,200 mg chlorpromazine (and 4 mg Benztropine to counteract early extrapyramidal side effects, which were anticipated with this unusual high chlorpromazine dose). Initial doses should be low and be increased gradually. It is recommended that most of the daily dose (e.g. 2/3) is given at bedtime for maximum hypnotic activity and minimal daytime sedation and hypotension. In the USA there are controlled release forms of Thorazine (e.g. 300 mg). After the individual dose is well established, such a CR capsule can be given with the evening meal as a single dose, covering the next 24 hours. The lowest dosage compatible with good therapeutic effect should be given. Dosage in ambulatory patients should be particularly low (minimizing sedation and hypotension). The direct i.v.-injection of undiluted solution is contraindicated (massive fall in blood pressure, cardiovascular collapse), for i.v.-infusion of dilutions the (hospitalized) patient should be lying and the infusion rate should be as slow as possible. Afterwards the patient should rest in the lying position for at least 30 minutes. [edit] Necessary examinations and laboratory checks during treatment All patients treated with chlorpromazine on a long-term-basis should have regularly checked their blood-pressure, pulse rate, laboratory-tests (liver function tests, kidney-values, blood cell counts including differenciated white blood counts, counts of red blood cells and thrombocytes), ECG and EEG. The frequency of all checks should be determined for the individual patient and may be done in shorter intervals during the first 3 months of treatment and less often afterwards. Some side effects seem to appear more frequently during the first months of therapy (sedation, hypotension, liver damage) while others do not (e.g. tardive dyskinesia). [edit] Discontinuation of treatment Also, in regular intervals the treating physician should evaluate whether continued treatment is needed. If not, the drug should never be stopped suddenly, due to very unpleasant 'withdrawal-symptoms', such as agitation, sleeplessness, states of anxiety, etc. However, these symptoms definitely do not indicate psychological or physical dependence. The dose should rather be slowly tapered down at a rate of approximately 20–25% per week or even slower to avoid the aforementioned bothersome symptoms. Chlorpromazine is derived from phenothiazine, and has an aliphatic side chain, typical for low to middle potency neuroleptics. The oral bioavailability is estimated to be 30–50% due to extensive first pass metabolization in the liver. Its elimination-halflife is 16–30 hours. It has many active metabolites (approx. 75 different ones) with greatly varying halflives and own pharmacological profiles. The CYP-450 isoenzymes 1A2 and 2D6 are needed for metabolization of chlorpromazine and the subtype 2D6 is inhibited by chlorpromazine (NB: possible interactions with other drugs). Answered by Irina Murriel 2 years ago.


What are some reasons why a person might be prescribed 200 mg of thorazine?
...from a medical prospective. Asked by Myrle Viele 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Nilsa Swenk 2 years ago.

The warding off man or woman will have angry through a comment the have shyed away from man or woman made. The warding off man or woman will have a few prejudice towards the have shyed away from man or woman. The have shyed away from man or woman might remind the warding off man or woman of an ex-boyfriend or ex-female friend or different man or woman who the warding off man or woman desires to omit. Maybe anybody instructed the warding off man or woman that the have shyed away from man or woman does not like him/her. But the object is, why do you care? Answered by Amiee Cerar 2 years ago.

It's an anti-psychotic, for bipolar disorder or schizophrenia. Answered by Noel Stoessel 2 years ago.


What is Thorazine, Lorazepam and Compazine? What are they used for?
Asked by Angel Lutke 2 years ago.

Chlorpromazine is classified as a low-potency typical antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of bipolar disorder, as well as amphetamine-induced psychoses. Low-potency antipsychotics have more anticholinergic side effects, such as dry mouth, sedation, and constipation, and lower rates of extrapyramidal side effects, while high-potency antipsychotics (such as haloperidol) have the reverse profile. Chlorpromazine has also been used in porphyria and as part of tetanus treatment. It still is recommended for short-term management of severe anxiety and psychotic aggression. Resistant and severe hiccups, severe nausea/emesis, and preanesthetic conditioning are other uses. Symptoms of delirium in medically-hospitalized AIDS patients have been effectively treated with low doses of chlorpromazine Answered by Zulma Toscani 2 years ago.

They are antipsycotic drugs used to treat manic depression, schizophrenia Answered by Theodore Spessard 2 years ago.


Is 25 mg of Thorazine safe to take for anxiety?
Asked by Robin Albanez 2 years ago.

Thorazine, at 25 mg, is used for chronic hiccups, nausea and vomitting, sedation before surgery, and sometimes anxiety. However, it is anti-psychotic, a tranquilizer, and very old school, so if it was not prescribed to you, don't tske it. This may just be a question of general curiosity, but if you need meds for anxiety, there are more suitable ones than thorazine. See the doc. to get the right one for you! Answered by Kerry Renneker 2 years ago.

Thorazine is not an anti-anxiety drug. It is an antipsychotic drug. Please do not take ANY prescription medication unless under the direction of your personal physician. Answered by Hae Carchidi 2 years ago.

I think I would speak to a Pharmacist before listening to someone on Yahoo answers. Answered by Carmen Lisk 2 years ago.

The potential for causing chronic movement disorders makes it far from ideal. Answered by Lai Durtsche 2 years ago.

It has more potential side effects than newer drugs. For example, seizures, heat exhaustion, drowsiness. Answered by Marnie Fester 2 years ago.


Is it true that Thorazine is as dangerous and the Psychiatric critics say it is?
From Psychiatric critics they criticize Thorazine a lot and say it messes people up like Lobotomy. Here is an example website criticizing Thorazine: http://www.sntp.net/drugs/thorazine.htm Asked by Juan Muncrief 2 years ago.

Thorazine is no more dangerous than the others. Staying on it for too long can lead to specific complications, which is true with other anti-psychotics. It isn't used as much these days, but it is still a consideration for some people. It's OK to critisize thorazine, but no more so than for other such drugs. Answered by Gertha Pownell 2 years ago.

Wow! Normally, I don't answer questions that want to learn more and more detail. As in your case, because they require a long process, and it is the risk of not solve all of yours problems. I would suggest to proceed analytically with the help of keywords to be included in Yahoo! From what you climb, narrowing the field with new keywords, until you will be fully satisfied. good luck! Answered by Eusebia Poundstone 2 years ago.


Is Thorazine(Chlorpromazine) an older anti-psychotic?
I was prescribed this recently for Bipolar Disorder. Is it an older anti-psychotic?Thanks Asked by Talitha Conrady 2 years ago.

Thorazine was one of the first anti-psychotics, created in 1950. It is still occasionally used in the treatment of schizophrenia and bipolar disorder, but not as often as it was a few decades ago. It's a low potency anti-psychotic, so there is a lower chance of experiencing unwanted side effects. Answered by Misha Owston 2 years ago.


How long will thorazine take to get in my urine stream?
i want to take a thorazine but i have a drug test at 10:00am and dont know what time yo take it so i can pass the drug test and still take it tonight Asked by Moshe Dardagnac 2 years ago.

To my understanding, Thorazine is an anti-psychotic medication. It's not typically screened for on a drug test. However, if you do register with a false positive in another drug category as a result of this medication, all you have to do is show proof of a prescription and you're in the clear. Thorazine is excreted primarily through the urine and has a half-life from 10 to 40 hours. Answered by Tatiana Lundquist 2 years ago.

You can't wait until after the test to take it - just to be on the safe side? Answered by Latesha Panowicz 2 years ago.


About Thorazine/Largactil?
I have read alot about this drug, but I would like to hear from somone that has actually used it, or someone who knows someone who has used it.How sedating/tranquilizing is it? What are the main side-effects, and what pills do I need to counteract these side-effects? Asked by Shanel Ruess 2 years ago.

About counteraction - I'm not sure. You'd have to take it to know if you'd have any counteractions, first. I took Thorazine for about a month for sleep. It never made me tired. It would, however, keep me asleep for 8-12 hrs once I laid down and fell asleep. Not a good drug if you need to be knocked out (in my opinion). I'm sure you've heard it called 'the chemical lobotomy'. I didn't feel like it erased too much of my personality, and I was still heavily addicted to drugs and it never made me seek/want drugs less. I really don't remember much from taking it. I snorted it once, and it burned like a SOB, but it knocked me out right away. Answered by Vallie Forsgren 2 years ago.


Mrs S. has been taking Thorazine for about 1 year?
She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the... Asked by Sona Eberwein 2 years ago.

She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the nursing diagnosis for this patient. a) What interventions would be used for this diagnosis? b) How would the nurse evaluate the outcome of the interventions? Answered by Lilliana Kesner 2 years ago.

thorazine is bound to have more severe side effects.. clozaril is an atypical antipsychotic drug, so it will be LESS likely to cause tardive dyskenesia and akathisia and other similarly devastating side effects (thanks to its anticholinergic properties). However, there is recent evidence that such drugs may increase the likelihood of metabolic disturbances (leading to diabetes) and cardiovascular disease. There are also sexual functioning side effects, but that is common to many psychotropic meds...Note that slow titration of dosing of Clozaril significantly decreases the likelihood of orthostatic hypotension, so the switch is right on the money for this mrs. s....... I would say the switch from thorazine to clozaril is not a bad idea. I have no idea what you mean by "knowledge deficit" and "nursing diagnosis", I'm coming from a clinical psych perspective, but hope this helps! Answered by Shelby Greytak 2 years ago.


What is thorazine used for?
Asked by Wes Kobbe 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Alvin Scholin 2 years ago.

Thorazine Uses Answered by Nicholas Ladner 2 years ago.

I don't know all of its uses, but I was given Thorazine for migraines. Answered by Maryam Dicus 2 years ago.

It is a old anti-psychotic. They use to use it a lot in psychiatric hospitals to calm down patients. It is also used for migraines at times. Answered by Sonja Casar 2 years ago.

To mess with kids minds! Answered by Breann Breth 2 years ago.

PAIN!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!... Answered by Anika Bearden 2 years ago.

Chlorpromazine was the first antipsychotic drug, used during the 1950s and 1960s. Used as chlorpromazine hydrochloride and sold under the tradenames Largactil® and Thorazine®, it has sedative, hypotensive and antiemetic properties as well as anticholinergic and antidopaminergic effects. It has also anxiolytic (alleviation of anxiety) properties. Today, chlorpromazine is considered a typical antipsychotic. Chlorpromazine acts as an antagonist (blocking agent) on different postsynaptic receptors: on dopaminergic-receptors (subtypes D1, D2, D3 and D4, different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), on alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism—controversial), and on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side effects). Additionally, chlorpromazine is a weak presynaptic inhibitor of dopamine reuptake, which may lead to (mild) antidepressive and antiparkinsonian effects. This action could also account for psychomotor agitation and amplification of psychosis (very rarely noted in clinical use). [edit] Peripheral Antagonist to H1 receptors (antiallergic effects), H2 receptors (reduction of forming of gastric juice), M1/M2-receptors (dry mouth, reduction in forming of gastric juice) and some 5-HT receptors (different anti-allergic/gastrointestinal actions). Because it acts on so many receptors, chlorpromazine is often referred to as "dirty drug", whereas the atypical neuroleptic amisulpride for example acts only on central D2/D3-receptors and is therefore a "clean drug". This distinction is not a positive or negative value judgment on the drug, rather it is a neutral term which merely describes the agent's relative pharmacology. [edit] History The drug had been developed by Laboratoires Rhône-Poulenc in 1950 but they sold the rights in 1952 to Smith-Kline & French (today's GlaxoSmithKline). The drug was being sold as an antiemetic when its other use was noted. Smith-Kline was quick to encourage clinical trials and in 1954 the drug was approved in the US for psychiatric treatment. Over 100 million people were treated but the popularity of the drug fell from the late 1960s as the severe extrapyramidal side effects and tardive dyskinesia became more of a concern. From chlorpromazine a number of other similar neuroleptics were developed (e.g. triflupromazine, trifluoperazine). Previously used as an antihistamine and antiemetic its effects on mental state were first reported by the French doctor Henri Laborit in 1951 or 1952 (different sources) as sedation without narcosis. It became possible to cause 'artificial hibernation' in patients, if used as a cocktail together with pethidine and hydergine. Patients with shock, severe trauma or burns, become, if treated so, sedated, without anxiety and unreponsive/indifferent to painful external stimuli like minor surgical interventions. It was first used for psychiatric patients by Pierre Deniker and Jean Delay in 1953. Drug treatment with chlorpromazine went beyond simple sedation with patients showing improvements in thinking and emotional behaviour. Ironically, the antipsychotic properties of chlorpromazine appear to be unrelated to its sedative properties. During long term therapy some tolerance to the sedation effect develops. Chlorpromazine substituted and eclipsed the old therapies of electro- and insulin shocks and other methods such as psychosurgical means (lobotomy) causing permanent brain injury. Chlorpromazine has given approximately 70% of all schizophrenic patients a complete remission or near so and a normal, gainful human life. Before the era of neuroleptics, starting with chlorpromazine, positive long-term results for psychotic patients were only 20%. [edit] Side effects Side effects of chlorpromazine are typical of early generation neuroleptics. They include extrapyramidal side effects such as tardive dyskinesia and akathisia. A particularly severe side effect is the neuroleptic malignant syndrome which occurs in approximately 0.05% and can be fatal. Also, chlorpromazine may lower seizure threshold. Additional side effects include dry mouth, increased appetite with weight gain, constipation and urinary retention. Glucose tolerance may be impaired. An allergic skin rash and photosensitivity may occur. Other important and severe side effects are a strong reduction in the number of white blood cells, referred to as leukopenia, or, in extreme cases, even agranulocytosis may result, which may lead to death via uncontrollable infections and/or sepsis. Chlorpromazine is the neuroleptic drug with the highest rates (0.5% to 1%) of liver toxicity of the cholestatic type. The sedation effect combined with indifference to physical stimuli, anecdotally known as the "thorazine shuffle," has long been associated with the drug. The image of psychiatric patients staggering mute around a padded cell has earned those particular side effects a place in mainstream pop culture. [edit] Interactions Chlorpromazine intensifies the central depressive action of drugs with such activity (tranquilizers, barbiturates, narcotics, antihistamines, OTC-antiemetics etc.). A dose reduction of chlorpromazine or the other drug may be necessary. Chlorpromazine also intensifies the actions and undesired side effects of antihypertensive medications and anticholinergic drugs. The combination of chlorpromazine with other antipsychotics may result in increased central depression, hypotension and extrapyramidal side effects, but may sometimes enhance the clinical results of therapy. The anti-worm drug (antihelminthic) piperazine may intensify extrapyramidal side effects. In general, all neuroleptics may lead to seizures in combination with tramadol (Ultram). Chlorpromazine may increase the insulin needs of diabetic patients. Drugs like SSRIs, St. John's Wort and barbiturates can inhibit various CYP-isoenzymes such as CYP2D6, needed for metabolization of chlorpromazine and/or its metabolites. Theoretically, this should increase the half-lives of chlorpromazine and possibly its metabolites, dosing changes necessary. The exact clinical significance of this enzyme induction and its therapeutic consequences are unknown at present time and remain to be evaluated. [edit] Uses [edit] Common uses [edit] As an antipsychotic The use of chlorpromazine has been primarily replaced by newer generation of atypical antipsychotics which have an improved side effect profile. Chlorpromazine is classified as a low- to moderate-potency antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of manic depression as well as amphetamine-induced psychoses. Chlorpromazine formerly was the drug of choice to treat LSD (and other psychedelic/hallucinogen) intoxication in a hospital setting, resulting in it gaining an erroneous reputation as the LSD "antidote". Now haloperidol is more commonly used in such situations. [edit] Other uses It has also been used in porphyria, as part of tetanus treatment and for behavioral problems in children. It still is well recommended for short term management of severe anxiety and aggressive episodes. Resistant and severe hiccups, severe nausea/emesis and preanesthetic conditioning have been other indications in the past. It can be used to treat amphetamine overdose. [1] [edit] Off-label and controversial uses Chlorpromazine is occasionally used off-label for treatment of severe migraine. Sometimes it is used in small doses to improve nausea/emesis opioid-treated cancer patients encounter and to intensify and prolong the analgesic action of the opioids given. Interestingly, it remains controversial whether or not chlorpromazine has its own analgesic properties. Analgesic properties may result from a central action on the hypothalamus; the patient may feel the pain much less than before. Other mechanisms may be an interaction with opioid receptors centrally and/or in the spinal cord. Some experts on the contrary say that chlorpromazine, like other phenothiazines, may even have antianalgesic properties. Chlorpromazine has been proposed as useful in newborns for the treatment of opioid withdrawal, if the mother was opioid-dependent. The latter indication remains highly controversial. Chlorpromazine, as well as other neuroleptics, may also be used to alleviate the symptoms of alcohol withdrawal (chlorpromazine may lower the seizure-threshold in alcoholics). It has a unique action in cholera, reducing the loss of water by approximately 30%. In Germany, the brand of chlorpromazine drug Propaphenin® has additional indications for insomnia and itching skin disease. [edit] Veterinary uses Chlorpromazine is primarily used as an antiemetic in dogs and cats. It is also sometimes used as a preanesthetic and muscle relaxant in cattle, swine, sheep, and goats. It is generally contraindicated for use with horses, due to a high incidence of ataxia and altered mentation. [edit] Dosage In any case, use is determined by an attending physician. The following information is intended to serve as a guideline: A wide range is covered from 25 mg oral or intramuscular for mild sedation, every 8 hours, up to 100 mg every 6 hours for severely disturbed patients. Different qualified sources give 800 mg/day to 1,200 mg/day as highest dose. At least there is one small clinical trial in treatment-resistant patients with a daily dose of 1,200 mg chlorpromazine (and 4 mg Benztropine to counteract early extrapyramidal side effects, which were anticipated with this unusual high chlorpromazine dose). Initial doses should be low and be increased gradually. It is recommended that most of the daily dose (e.g. 2/3) is given at bedtime for maximum hypnotic activity and minimal daytime sedation and hypotension. In the USA there are controlled release forms of Thorazine (e.g. 300 mg). After the individual dose is well established, such a CR capsule can be given with the evening meal as a single dose, covering the next 24 hours. The lowest dosage compatible with good therapeutic effect should be given. Dosage in ambulatory patients should be particularly low (minimizing sedation and hypotension). The direct i.v.-injection of undiluted solution is contraindicated (massive fall in blood pressure, cardiovascular collapse), for i.v.-infusion of dilutions the (hospitalized) patient should be lying and the infusion rate should be as slow as possible. Afterwards the patient should rest in the lying position for at least 30 minutes. [edit] Necessary examinations and laboratory checks during treatment All patients treated with chlorpromazine on a long-term-basis should have regularly checked their blood-pressure, pulse rate, laboratory-tests (liver function tests, kidney-values, blood cell counts including differenciated white blood counts, counts of red blood cells and thrombocytes), ECG and EEG. The frequency of all checks should be determined for the individual patient and may be done in shorter intervals during the first 3 months of treatment and less often afterwards. Some side effects seem to appear more frequently during the first months of therapy (sedation, hypotension, liver damage) while others do not (e.g. tardive dyskinesia). [edit] Discontinuation of treatment Also, in regular intervals the treating physician should evaluate whether continued treatment is needed. If not, the drug should never be stopped suddenly, due to very unpleasant 'withdrawal-symptoms', such as agitation, sleeplessness, states of anxiety, etc. However, these symptoms definitely do not indicate psychological or physical dependence. The dose should rather be slowly tapered down at a rate of approximately 20–25% per week or even slower to avoid the aforementioned bothersome symptoms. Chlorpromazine is derived from phenothiazine, and has an aliphatic side chain, typical for low to middle potency neuroleptics. The oral bioavailability is estimated to be 30–50% due to extensive first pass metabolization in the liver. Its elimination-halflife is 16–30 hours. It has many active metabolites (approx. 75 different ones) with greatly varying halflives and own pharmacological profiles. The CYP-450 isoenzymes 1A2 and 2D6 are needed for metabolization of chlorpromazine and the subtype 2D6 is inhibited by chlorpromazine (NB: possible interactions with other drugs). Answered by Monroe Tibbitts 2 years ago.


What are some reasons why a person might be prescribed 200 mg of thorazine?
...from a medical prospective. Asked by Andrea Voros 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Thresa Gerfin 2 years ago.

The warding off man or woman will have angry through a comment the have shyed away from man or woman made. The warding off man or woman will have a few prejudice towards the have shyed away from man or woman. The have shyed away from man or woman might remind the warding off man or woman of an ex-boyfriend or ex-female friend or different man or woman who the warding off man or woman desires to omit. Maybe anybody instructed the warding off man or woman that the have shyed away from man or woman does not like him/her. But the object is, why do you care? Answered by Andrew Dahlgren 2 years ago.

It's an anti-psychotic, for bipolar disorder or schizophrenia. Answered by Myung Dillow 2 years ago.


What is Thorazine, Lorazepam and Compazine? What are they used for?
Asked by Yolande Mccan 2 years ago.

Chlorpromazine is classified as a low-potency typical antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of bipolar disorder, as well as amphetamine-induced psychoses. Low-potency antipsychotics have more anticholinergic side effects, such as dry mouth, sedation, and constipation, and lower rates of extrapyramidal side effects, while high-potency antipsychotics (such as haloperidol) have the reverse profile. Chlorpromazine has also been used in porphyria and as part of tetanus treatment. It still is recommended for short-term management of severe anxiety and psychotic aggression. Resistant and severe hiccups, severe nausea/emesis, and preanesthetic conditioning are other uses. Symptoms of delirium in medically-hospitalized AIDS patients have been effectively treated with low doses of chlorpromazine Answered by Lincoln Merkwan 2 years ago.

They are antipsycotic drugs used to treat manic depression, schizophrenia Answered by Viki Koepper 2 years ago.


Is 25 mg of Thorazine safe to take for anxiety?
Asked by Vito Wasem 2 years ago.

Thorazine, at 25 mg, is used for chronic hiccups, nausea and vomitting, sedation before surgery, and sometimes anxiety. However, it is anti-psychotic, a tranquilizer, and very old school, so if it was not prescribed to you, don't tske it. This may just be a question of general curiosity, but if you need meds for anxiety, there are more suitable ones than thorazine. See the doc. to get the right one for you! Answered by Adrianna Moscoffian 2 years ago.

Thorazine is not an anti-anxiety drug. It is an antipsychotic drug. Please do not take ANY prescription medication unless under the direction of your personal physician. Answered by Flor Gartenmayer 2 years ago.

I think I would speak to a Pharmacist before listening to someone on Yahoo answers. Answered by Isidro Flechsig 2 years ago.

The potential for causing chronic movement disorders makes it far from ideal. Answered by Trish Dekalb 2 years ago.

It has more potential side effects than newer drugs. For example, seizures, heat exhaustion, drowsiness. Answered by Sanora Dutro 2 years ago.


Is it true that Thorazine is as dangerous and the Psychiatric critics say it is?
From Psychiatric critics they criticize Thorazine a lot and say it messes people up like Lobotomy. Here is an example website criticizing Thorazine: http://www.sntp.net/drugs/thorazine.htm Asked by Yael Lockner 2 years ago.

Thorazine is no more dangerous than the others. Staying on it for too long can lead to specific complications, which is true with other anti-psychotics. It isn't used as much these days, but it is still a consideration for some people. It's OK to critisize thorazine, but no more so than for other such drugs. Answered by Taren Zarlengo 2 years ago.

Wow! Normally, I don't answer questions that want to learn more and more detail. As in your case, because they require a long process, and it is the risk of not solve all of yours problems. I would suggest to proceed analytically with the help of keywords to be included in Yahoo! From what you climb, narrowing the field with new keywords, until you will be fully satisfied. good luck! Answered by Fred Mason 2 years ago.


Is Thorazine(Chlorpromazine) an older anti-psychotic?
I was prescribed this recently for Bipolar Disorder. Is it an older anti-psychotic?Thanks Asked by Misti Lippy 2 years ago.

Thorazine was one of the first anti-psychotics, created in 1950. It is still occasionally used in the treatment of schizophrenia and bipolar disorder, but not as often as it was a few decades ago. It's a low potency anti-psychotic, so there is a lower chance of experiencing unwanted side effects. Answered by Rhett Leveto 2 years ago.


How long will thorazine take to get in my urine stream?
i want to take a thorazine but i have a drug test at 10:00am and dont know what time yo take it so i can pass the drug test and still take it tonight Asked by Sharan Crowley 2 years ago.

To my understanding, Thorazine is an anti-psychotic medication. It's not typically screened for on a drug test. However, if you do register with a false positive in another drug category as a result of this medication, all you have to do is show proof of a prescription and you're in the clear. Thorazine is excreted primarily through the urine and has a half-life from 10 to 40 hours. Answered by Maryjo Stabler 2 years ago.

You can't wait until after the test to take it - just to be on the safe side? Answered by Kimberly Dysart 2 years ago.


About Thorazine/Largactil?
I have read alot about this drug, but I would like to hear from somone that has actually used it, or someone who knows someone who has used it.How sedating/tranquilizing is it? What are the main side-effects, and what pills do I need to counteract these side-effects? Asked by Benny Dann 2 years ago.

About counteraction - I'm not sure. You'd have to take it to know if you'd have any counteractions, first. I took Thorazine for about a month for sleep. It never made me tired. It would, however, keep me asleep for 8-12 hrs once I laid down and fell asleep. Not a good drug if you need to be knocked out (in my opinion). I'm sure you've heard it called 'the chemical lobotomy'. I didn't feel like it erased too much of my personality, and I was still heavily addicted to drugs and it never made me seek/want drugs less. I really don't remember much from taking it. I snorted it once, and it burned like a SOB, but it knocked me out right away. Answered by Jon Demaranville 2 years ago.


Mrs S. has been taking Thorazine for about 1 year?
She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the... Asked by Charles Gilliss 2 years ago.

She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the nursing diagnosis for this patient. a) What interventions would be used for this diagnosis? b) How would the nurse evaluate the outcome of the interventions? Answered by Collen Yeakle 2 years ago.

thorazine is bound to have more severe side effects.. clozaril is an atypical antipsychotic drug, so it will be LESS likely to cause tardive dyskenesia and akathisia and other similarly devastating side effects (thanks to its anticholinergic properties). However, there is recent evidence that such drugs may increase the likelihood of metabolic disturbances (leading to diabetes) and cardiovascular disease. There are also sexual functioning side effects, but that is common to many psychotropic meds...Note that slow titration of dosing of Clozaril significantly decreases the likelihood of orthostatic hypotension, so the switch is right on the money for this mrs. s....... I would say the switch from thorazine to clozaril is not a bad idea. I have no idea what you mean by "knowledge deficit" and "nursing diagnosis", I'm coming from a clinical psych perspective, but hope this helps! Answered by Sheree Partee 2 years ago.


What is thorazine used for?
Asked by Ava Pinela 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Racquel Spatafore 2 years ago.

Thorazine Uses Answered by Melody Peroutka 2 years ago.

I don't know all of its uses, but I was given Thorazine for migraines. Answered by Ria Cravatta 2 years ago.

It is a old anti-psychotic. They use to use it a lot in psychiatric hospitals to calm down patients. It is also used for migraines at times. Answered by Charlene Lovejoy 2 years ago.

To mess with kids minds! Answered by Julian Wilkson 2 years ago.

PAIN!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!... Answered by Rey Janoski 2 years ago.

Chlorpromazine was the first antipsychotic drug, used during the 1950s and 1960s. Used as chlorpromazine hydrochloride and sold under the tradenames Largactil® and Thorazine®, it has sedative, hypotensive and antiemetic properties as well as anticholinergic and antidopaminergic effects. It has also anxiolytic (alleviation of anxiety) properties. Today, chlorpromazine is considered a typical antipsychotic. Chlorpromazine acts as an antagonist (blocking agent) on different postsynaptic receptors: on dopaminergic-receptors (subtypes D1, D2, D3 and D4, different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), on alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism—controversial), and on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side effects). Additionally, chlorpromazine is a weak presynaptic inhibitor of dopamine reuptake, which may lead to (mild) antidepressive and antiparkinsonian effects. This action could also account for psychomotor agitation and amplification of psychosis (very rarely noted in clinical use). [edit] Peripheral Antagonist to H1 receptors (antiallergic effects), H2 receptors (reduction of forming of gastric juice), M1/M2-receptors (dry mouth, reduction in forming of gastric juice) and some 5-HT receptors (different anti-allergic/gastrointestinal actions). Because it acts on so many receptors, chlorpromazine is often referred to as "dirty drug", whereas the atypical neuroleptic amisulpride for example acts only on central D2/D3-receptors and is therefore a "clean drug". This distinction is not a positive or negative value judgment on the drug, rather it is a neutral term which merely describes the agent's relative pharmacology. [edit] History The drug had been developed by Laboratoires Rhône-Poulenc in 1950 but they sold the rights in 1952 to Smith-Kline & French (today's GlaxoSmithKline). The drug was being sold as an antiemetic when its other use was noted. Smith-Kline was quick to encourage clinical trials and in 1954 the drug was approved in the US for psychiatric treatment. Over 100 million people were treated but the popularity of the drug fell from the late 1960s as the severe extrapyramidal side effects and tardive dyskinesia became more of a concern. From chlorpromazine a number of other similar neuroleptics were developed (e.g. triflupromazine, trifluoperazine). Previously used as an antihistamine and antiemetic its effects on mental state were first reported by the French doctor Henri Laborit in 1951 or 1952 (different sources) as sedation without narcosis. It became possible to cause 'artificial hibernation' in patients, if used as a cocktail together with pethidine and hydergine. Patients with shock, severe trauma or burns, become, if treated so, sedated, without anxiety and unreponsive/indifferent to painful external stimuli like minor surgical interventions. It was first used for psychiatric patients by Pierre Deniker and Jean Delay in 1953. Drug treatment with chlorpromazine went beyond simple sedation with patients showing improvements in thinking and emotional behaviour. Ironically, the antipsychotic properties of chlorpromazine appear to be unrelated to its sedative properties. During long term therapy some tolerance to the sedation effect develops. Chlorpromazine substituted and eclipsed the old therapies of electro- and insulin shocks and other methods such as psychosurgical means (lobotomy) causing permanent brain injury. Chlorpromazine has given approximately 70% of all schizophrenic patients a complete remission or near so and a normal, gainful human life. Before the era of neuroleptics, starting with chlorpromazine, positive long-term results for psychotic patients were only 20%. [edit] Side effects Side effects of chlorpromazine are typical of early generation neuroleptics. They include extrapyramidal side effects such as tardive dyskinesia and akathisia. A particularly severe side effect is the neuroleptic malignant syndrome which occurs in approximately 0.05% and can be fatal. Also, chlorpromazine may lower seizure threshold. Additional side effects include dry mouth, increased appetite with weight gain, constipation and urinary retention. Glucose tolerance may be impaired. An allergic skin rash and photosensitivity may occur. Other important and severe side effects are a strong reduction in the number of white blood cells, referred to as leukopenia, or, in extreme cases, even agranulocytosis may result, which may lead to death via uncontrollable infections and/or sepsis. Chlorpromazine is the neuroleptic drug with the highest rates (0.5% to 1%) of liver toxicity of the cholestatic type. The sedation effect combined with indifference to physical stimuli, anecdotally known as the "thorazine shuffle," has long been associated with the drug. The image of psychiatric patients staggering mute around a padded cell has earned those particular side effects a place in mainstream pop culture. [edit] Interactions Chlorpromazine intensifies the central depressive action of drugs with such activity (tranquilizers, barbiturates, narcotics, antihistamines, OTC-antiemetics etc.). A dose reduction of chlorpromazine or the other drug may be necessary. Chlorpromazine also intensifies the actions and undesired side effects of antihypertensive medications and anticholinergic drugs. The combination of chlorpromazine with other antipsychotics may result in increased central depression, hypotension and extrapyramidal side effects, but may sometimes enhance the clinical results of therapy. The anti-worm drug (antihelminthic) piperazine may intensify extrapyramidal side effects. In general, all neuroleptics may lead to seizures in combination with tramadol (Ultram). Chlorpromazine may increase the insulin needs of diabetic patients. Drugs like SSRIs, St. John's Wort and barbiturates can inhibit various CYP-isoenzymes such as CYP2D6, needed for metabolization of chlorpromazine and/or its metabolites. Theoretically, this should increase the half-lives of chlorpromazine and possibly its metabolites, dosing changes necessary. The exact clinical significance of this enzyme induction and its therapeutic consequences are unknown at present time and remain to be evaluated. [edit] Uses [edit] Common uses [edit] As an antipsychotic The use of chlorpromazine has been primarily replaced by newer generation of atypical antipsychotics which have an improved side effect profile. Chlorpromazine is classified as a low- to moderate-potency antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of manic depression as well as amphetamine-induced psychoses. Chlorpromazine formerly was the drug of choice to treat LSD (and other psychedelic/hallucinogen) intoxication in a hospital setting, resulting in it gaining an erroneous reputation as the LSD "antidote". Now haloperidol is more commonly used in such situations. [edit] Other uses It has also been used in porphyria, as part of tetanus treatment and for behavioral problems in children. It still is well recommended for short term management of severe anxiety and aggressive episodes. Resistant and severe hiccups, severe nausea/emesis and preanesthetic conditioning have been other indications in the past. It can be used to treat amphetamine overdose. [1] [edit] Off-label and controversial uses Chlorpromazine is occasionally used off-label for treatment of severe migraine. Sometimes it is used in small doses to improve nausea/emesis opioid-treated cancer patients encounter and to intensify and prolong the analgesic action of the opioids given. Interestingly, it remains controversial whether or not chlorpromazine has its own analgesic properties. Analgesic properties may result from a central action on the hypothalamus; the patient may feel the pain much less than before. Other mechanisms may be an interaction with opioid receptors centrally and/or in the spinal cord. Some experts on the contrary say that chlorpromazine, like other phenothiazines, may even have antianalgesic properties. Chlorpromazine has been proposed as useful in newborns for the treatment of opioid withdrawal, if the mother was opioid-dependent. The latter indication remains highly controversial. Chlorpromazine, as well as other neuroleptics, may also be used to alleviate the symptoms of alcohol withdrawal (chlorpromazine may lower the seizure-threshold in alcoholics). It has a unique action in cholera, reducing the loss of water by approximately 30%. In Germany, the brand of chlorpromazine drug Propaphenin® has additional indications for insomnia and itching skin disease. [edit] Veterinary uses Chlorpromazine is primarily used as an antiemetic in dogs and cats. It is also sometimes used as a preanesthetic and muscle relaxant in cattle, swine, sheep, and goats. It is generally contraindicated for use with horses, due to a high incidence of ataxia and altered mentation. [edit] Dosage In any case, use is determined by an attending physician. The following information is intended to serve as a guideline: A wide range is covered from 25 mg oral or intramuscular for mild sedation, every 8 hours, up to 100 mg every 6 hours for severely disturbed patients. Different qualified sources give 800 mg/day to 1,200 mg/day as highest dose. At least there is one small clinical trial in treatment-resistant patients with a daily dose of 1,200 mg chlorpromazine (and 4 mg Benztropine to counteract early extrapyramidal side effects, which were anticipated with this unusual high chlorpromazine dose). Initial doses should be low and be increased gradually. It is recommended that most of the daily dose (e.g. 2/3) is given at bedtime for maximum hypnotic activity and minimal daytime sedation and hypotension. In the USA there are controlled release forms of Thorazine (e.g. 300 mg). After the individual dose is well established, such a CR capsule can be given with the evening meal as a single dose, covering the next 24 hours. The lowest dosage compatible with good therapeutic effect should be given. Dosage in ambulatory patients should be particularly low (minimizing sedation and hypotension). The direct i.v.-injection of undiluted solution is contraindicated (massive fall in blood pressure, cardiovascular collapse), for i.v.-infusion of dilutions the (hospitalized) patient should be lying and the infusion rate should be as slow as possible. Afterwards the patient should rest in the lying position for at least 30 minutes. [edit] Necessary examinations and laboratory checks during treatment All patients treated with chlorpromazine on a long-term-basis should have regularly checked their blood-pressure, pulse rate, laboratory-tests (liver function tests, kidney-values, blood cell counts including differenciated white blood counts, counts of red blood cells and thrombocytes), ECG and EEG. The frequency of all checks should be determined for the individual patient and may be done in shorter intervals during the first 3 months of treatment and less often afterwards. Some side effects seem to appear more frequently during the first months of therapy (sedation, hypotension, liver damage) while others do not (e.g. tardive dyskinesia). [edit] Discontinuation of treatment Also, in regular intervals the treating physician should evaluate whether continued treatment is needed. If not, the drug should never be stopped suddenly, due to very unpleasant 'withdrawal-symptoms', such as agitation, sleeplessness, states of anxiety, etc. However, these symptoms definitely do not indicate psychological or physical dependence. The dose should rather be slowly tapered down at a rate of approximately 20–25% per week or even slower to avoid the aforementioned bothersome symptoms. Chlorpromazine is derived from phenothiazine, and has an aliphatic side chain, typical for low to middle potency neuroleptics. The oral bioavailability is estimated to be 30–50% due to extensive first pass metabolization in the liver. Its elimination-halflife is 16–30 hours. It has many active metabolites (approx. 75 different ones) with greatly varying halflives and own pharmacological profiles. The CYP-450 isoenzymes 1A2 and 2D6 are needed for metabolization of chlorpromazine and the subtype 2D6 is inhibited by chlorpromazine (NB: possible interactions with other drugs). Answered by Mayra Leleux 2 years ago.


What are some reasons why a person might be prescribed 200 mg of thorazine?
...from a medical prospective. Asked by Francisco Carpinelli 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Adeline Malik 2 years ago.

The warding off man or woman will have angry through a comment the have shyed away from man or woman made. The warding off man or woman will have a few prejudice towards the have shyed away from man or woman. The have shyed away from man or woman might remind the warding off man or woman of an ex-boyfriend or ex-female friend or different man or woman who the warding off man or woman desires to omit. Maybe anybody instructed the warding off man or woman that the have shyed away from man or woman does not like him/her. But the object is, why do you care? Answered by Jordan Pompi 2 years ago.

It's an anti-psychotic, for bipolar disorder or schizophrenia. Answered by Randy Koehly 2 years ago.


What is Thorazine, Lorazepam and Compazine? What are they used for?
Asked by Lorrine Magnani 2 years ago.

Chlorpromazine is classified as a low-potency typical antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of bipolar disorder, as well as amphetamine-induced psychoses. Low-potency antipsychotics have more anticholinergic side effects, such as dry mouth, sedation, and constipation, and lower rates of extrapyramidal side effects, while high-potency antipsychotics (such as haloperidol) have the reverse profile. Chlorpromazine has also been used in porphyria and as part of tetanus treatment. It still is recommended for short-term management of severe anxiety and psychotic aggression. Resistant and severe hiccups, severe nausea/emesis, and preanesthetic conditioning are other uses. Symptoms of delirium in medically-hospitalized AIDS patients have been effectively treated with low doses of chlorpromazine Answered by Barbie Vanderlaan 2 years ago.

They are antipsycotic drugs used to treat manic depression, schizophrenia Answered by Sharda Bishoff 2 years ago.


Is 25 mg of Thorazine safe to take for anxiety?
Asked by Teisha Funari 2 years ago.

Thorazine, at 25 mg, is used for chronic hiccups, nausea and vomitting, sedation before surgery, and sometimes anxiety. However, it is anti-psychotic, a tranquilizer, and very old school, so if it was not prescribed to you, don't tske it. This may just be a question of general curiosity, but if you need meds for anxiety, there are more suitable ones than thorazine. See the doc. to get the right one for you! Answered by Delfina Glasby 2 years ago.

Thorazine is not an anti-anxiety drug. It is an antipsychotic drug. Please do not take ANY prescription medication unless under the direction of your personal physician. Answered by Aurora Zipkin 2 years ago.

I think I would speak to a Pharmacist before listening to someone on Yahoo answers. Answered by Candie Beschorner 2 years ago.

The potential for causing chronic movement disorders makes it far from ideal. Answered by Chassidy Bierschbach 2 years ago.

It has more potential side effects than newer drugs. For example, seizures, heat exhaustion, drowsiness. Answered by Shoshana Lovins 2 years ago.


Is it true that Thorazine is as dangerous and the Psychiatric critics say it is?
From Psychiatric critics they criticize Thorazine a lot and say it messes people up like Lobotomy. Here is an example website criticizing Thorazine: http://www.sntp.net/drugs/thorazine.htm Asked by Carey Manis 2 years ago.

Thorazine is no more dangerous than the others. Staying on it for too long can lead to specific complications, which is true with other anti-psychotics. It isn't used as much these days, but it is still a consideration for some people. It's OK to critisize thorazine, but no more so than for other such drugs. Answered by Robert Neddenriep 2 years ago.

Wow! Normally, I don't answer questions that want to learn more and more detail. As in your case, because they require a long process, and it is the risk of not solve all of yours problems. I would suggest to proceed analytically with the help of keywords to be included in Yahoo! From what you climb, narrowing the field with new keywords, until you will be fully satisfied. good luck! Answered by Guillermo Priore 2 years ago.


Is Thorazine(Chlorpromazine) an older anti-psychotic?
I was prescribed this recently for Bipolar Disorder. Is it an older anti-psychotic?Thanks Asked by Milton Harton 2 years ago.

Thorazine was one of the first anti-psychotics, created in 1950. It is still occasionally used in the treatment of schizophrenia and bipolar disorder, but not as often as it was a few decades ago. It's a low potency anti-psychotic, so there is a lower chance of experiencing unwanted side effects. Answered by Janelle Cerda 2 years ago.


How long will thorazine take to get in my urine stream?
i want to take a thorazine but i have a drug test at 10:00am and dont know what time yo take it so i can pass the drug test and still take it tonight Asked by Kelsie Ragusa 2 years ago.

To my understanding, Thorazine is an anti-psychotic medication. It's not typically screened for on a drug test. However, if you do register with a false positive in another drug category as a result of this medication, all you have to do is show proof of a prescription and you're in the clear. Thorazine is excreted primarily through the urine and has a half-life from 10 to 40 hours. Answered by Hilton Katra 2 years ago.

You can't wait until after the test to take it - just to be on the safe side? Answered by Louetta Mathern 2 years ago.


About Thorazine/Largactil?
I have read alot about this drug, but I would like to hear from somone that has actually used it, or someone who knows someone who has used it.How sedating/tranquilizing is it? What are the main side-effects, and what pills do I need to counteract these side-effects? Asked by Eleni Samora 2 years ago.

About counteraction - I'm not sure. You'd have to take it to know if you'd have any counteractions, first. I took Thorazine for about a month for sleep. It never made me tired. It would, however, keep me asleep for 8-12 hrs once I laid down and fell asleep. Not a good drug if you need to be knocked out (in my opinion). I'm sure you've heard it called 'the chemical lobotomy'. I didn't feel like it erased too much of my personality, and I was still heavily addicted to drugs and it never made me seek/want drugs less. I really don't remember much from taking it. I snorted it once, and it burned like a SOB, but it knocked me out right away. Answered by Leonard Odenheimer 2 years ago.


Mrs S. has been taking Thorazine for about 1 year?
She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the... Asked by Arcelia Marzella 2 years ago.

She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the nursing diagnosis for this patient. a) What interventions would be used for this diagnosis? b) How would the nurse evaluate the outcome of the interventions? Answered by Cleo Biorkman 2 years ago.

thorazine is bound to have more severe side effects.. clozaril is an atypical antipsychotic drug, so it will be LESS likely to cause tardive dyskenesia and akathisia and other similarly devastating side effects (thanks to its anticholinergic properties). However, there is recent evidence that such drugs may increase the likelihood of metabolic disturbances (leading to diabetes) and cardiovascular disease. There are also sexual functioning side effects, but that is common to many psychotropic meds...Note that slow titration of dosing of Clozaril significantly decreases the likelihood of orthostatic hypotension, so the switch is right on the money for this mrs. s....... I would say the switch from thorazine to clozaril is not a bad idea. I have no idea what you mean by "knowledge deficit" and "nursing diagnosis", I'm coming from a clinical psych perspective, but hope this helps! Answered by Desire Beckerdite 2 years ago.


What is thorazine used for?
Asked by Eden Paladin 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Bernie Cockley 2 years ago.

Thorazine Uses Answered by Louis Aegerter 2 years ago.

I don't know all of its uses, but I was given Thorazine for migraines. Answered by Evette Carovski 2 years ago.

It is a old anti-psychotic. They use to use it a lot in psychiatric hospitals to calm down patients. It is also used for migraines at times. Answered by Dahlia Hatstat 2 years ago.

To mess with kids minds! Answered by Ivy Milkowski 2 years ago.

PAIN!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!... Answered by Candra Aylor 2 years ago.

Chlorpromazine was the first antipsychotic drug, used during the 1950s and 1960s. Used as chlorpromazine hydrochloride and sold under the tradenames Largactil® and Thorazine®, it has sedative, hypotensive and antiemetic properties as well as anticholinergic and antidopaminergic effects. It has also anxiolytic (alleviation of anxiety) properties. Today, chlorpromazine is considered a typical antipsychotic. Chlorpromazine acts as an antagonist (blocking agent) on different postsynaptic receptors: on dopaminergic-receptors (subtypes D1, D2, D3 and D4, different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), on alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism—controversial), and on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side effects). Additionally, chlorpromazine is a weak presynaptic inhibitor of dopamine reuptake, which may lead to (mild) antidepressive and antiparkinsonian effects. This action could also account for psychomotor agitation and amplification of psychosis (very rarely noted in clinical use). [edit] Peripheral Antagonist to H1 receptors (antiallergic effects), H2 receptors (reduction of forming of gastric juice), M1/M2-receptors (dry mouth, reduction in forming of gastric juice) and some 5-HT receptors (different anti-allergic/gastrointestinal actions). Because it acts on so many receptors, chlorpromazine is often referred to as "dirty drug", whereas the atypical neuroleptic amisulpride for example acts only on central D2/D3-receptors and is therefore a "clean drug". This distinction is not a positive or negative value judgment on the drug, rather it is a neutral term which merely describes the agent's relative pharmacology. [edit] History The drug had been developed by Laboratoires Rhône-Poulenc in 1950 but they sold the rights in 1952 to Smith-Kline & French (today's GlaxoSmithKline). The drug was being sold as an antiemetic when its other use was noted. Smith-Kline was quick to encourage clinical trials and in 1954 the drug was approved in the US for psychiatric treatment. Over 100 million people were treated but the popularity of the drug fell from the late 1960s as the severe extrapyramidal side effects and tardive dyskinesia became more of a concern. From chlorpromazine a number of other similar neuroleptics were developed (e.g. triflupromazine, trifluoperazine). Previously used as an antihistamine and antiemetic its effects on mental state were first reported by the French doctor Henri Laborit in 1951 or 1952 (different sources) as sedation without narcosis. It became possible to cause 'artificial hibernation' in patients, if used as a cocktail together with pethidine and hydergine. Patients with shock, severe trauma or burns, become, if treated so, sedated, without anxiety and unreponsive/indifferent to painful external stimuli like minor surgical interventions. It was first used for psychiatric patients by Pierre Deniker and Jean Delay in 1953. Drug treatment with chlorpromazine went beyond simple sedation with patients showing improvements in thinking and emotional behaviour. Ironically, the antipsychotic properties of chlorpromazine appear to be unrelated to its sedative properties. During long term therapy some tolerance to the sedation effect develops. Chlorpromazine substituted and eclipsed the old therapies of electro- and insulin shocks and other methods such as psychosurgical means (lobotomy) causing permanent brain injury. Chlorpromazine has given approximately 70% of all schizophrenic patients a complete remission or near so and a normal, gainful human life. Before the era of neuroleptics, starting with chlorpromazine, positive long-term results for psychotic patients were only 20%. [edit] Side effects Side effects of chlorpromazine are typical of early generation neuroleptics. They include extrapyramidal side effects such as tardive dyskinesia and akathisia. A particularly severe side effect is the neuroleptic malignant syndrome which occurs in approximately 0.05% and can be fatal. Also, chlorpromazine may lower seizure threshold. Additional side effects include dry mouth, increased appetite with weight gain, constipation and urinary retention. Glucose tolerance may be impaired. An allergic skin rash and photosensitivity may occur. Other important and severe side effects are a strong reduction in the number of white blood cells, referred to as leukopenia, or, in extreme cases, even agranulocytosis may result, which may lead to death via uncontrollable infections and/or sepsis. Chlorpromazine is the neuroleptic drug with the highest rates (0.5% to 1%) of liver toxicity of the cholestatic type. The sedation effect combined with indifference to physical stimuli, anecdotally known as the "thorazine shuffle," has long been associated with the drug. The image of psychiatric patients staggering mute around a padded cell has earned those particular side effects a place in mainstream pop culture. [edit] Interactions Chlorpromazine intensifies the central depressive action of drugs with such activity (tranquilizers, barbiturates, narcotics, antihistamines, OTC-antiemetics etc.). A dose reduction of chlorpromazine or the other drug may be necessary. Chlorpromazine also intensifies the actions and undesired side effects of antihypertensive medications and anticholinergic drugs. The combination of chlorpromazine with other antipsychotics may result in increased central depression, hypotension and extrapyramidal side effects, but may sometimes enhance the clinical results of therapy. The anti-worm drug (antihelminthic) piperazine may intensify extrapyramidal side effects. In general, all neuroleptics may lead to seizures in combination with tramadol (Ultram). Chlorpromazine may increase the insulin needs of diabetic patients. Drugs like SSRIs, St. John's Wort and barbiturates can inhibit various CYP-isoenzymes such as CYP2D6, needed for metabolization of chlorpromazine and/or its metabolites. Theoretically, this should increase the half-lives of chlorpromazine and possibly its metabolites, dosing changes necessary. The exact clinical significance of this enzyme induction and its therapeutic consequences are unknown at present time and remain to be evaluated. [edit] Uses [edit] Common uses [edit] As an antipsychotic The use of chlorpromazine has been primarily replaced by newer generation of atypical antipsychotics which have an improved side effect profile. Chlorpromazine is classified as a low- to moderate-potency antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of manic depression as well as amphetamine-induced psychoses. Chlorpromazine formerly was the drug of choice to treat LSD (and other psychedelic/hallucinogen) intoxication in a hospital setting, resulting in it gaining an erroneous reputation as the LSD "antidote". Now haloperidol is more commonly used in such situations. [edit] Other uses It has also been used in porphyria, as part of tetanus treatment and for behavioral problems in children. It still is well recommended for short term management of severe anxiety and aggressive episodes. Resistant and severe hiccups, severe nausea/emesis and preanesthetic conditioning have been other indications in the past. It can be used to treat amphetamine overdose. [1] [edit] Off-label and controversial uses Chlorpromazine is occasionally used off-label for treatment of severe migraine. Sometimes it is used in small doses to improve nausea/emesis opioid-treated cancer patients encounter and to intensify and prolong the analgesic action of the opioids given. Interestingly, it remains controversial whether or not chlorpromazine has its own analgesic properties. Analgesic properties may result from a central action on the hypothalamus; the patient may feel the pain much less than before. Other mechanisms may be an interaction with opioid receptors centrally and/or in the spinal cord. Some experts on the contrary say that chlorpromazine, like other phenothiazines, may even have antianalgesic properties. Chlorpromazine has been proposed as useful in newborns for the treatment of opioid withdrawal, if the mother was opioid-dependent. The latter indication remains highly controversial. Chlorpromazine, as well as other neuroleptics, may also be used to alleviate the symptoms of alcohol withdrawal (chlorpromazine may lower the seizure-threshold in alcoholics). It has a unique action in cholera, reducing the loss of water by approximately 30%. In Germany, the brand of chlorpromazine drug Propaphenin® has additional indications for insomnia and itching skin disease. [edit] Veterinary uses Chlorpromazine is primarily used as an antiemetic in dogs and cats. It is also sometimes used as a preanesthetic and muscle relaxant in cattle, swine, sheep, and goats. It is generally contraindicated for use with horses, due to a high incidence of ataxia and altered mentation. [edit] Dosage In any case, use is determined by an attending physician. The following information is intended to serve as a guideline: A wide range is covered from 25 mg oral or intramuscular for mild sedation, every 8 hours, up to 100 mg every 6 hours for severely disturbed patients. Different qualified sources give 800 mg/day to 1,200 mg/day as highest dose. At least there is one small clinical trial in treatment-resistant patients with a daily dose of 1,200 mg chlorpromazine (and 4 mg Benztropine to counteract early extrapyramidal side effects, which were anticipated with this unusual high chlorpromazine dose). Initial doses should be low and be increased gradually. It is recommended that most of the daily dose (e.g. 2/3) is given at bedtime for maximum hypnotic activity and minimal daytime sedation and hypotension. In the USA there are controlled release forms of Thorazine (e.g. 300 mg). After the individual dose is well established, such a CR capsule can be given with the evening meal as a single dose, covering the next 24 hours. The lowest dosage compatible with good therapeutic effect should be given. Dosage in ambulatory patients should be particularly low (minimizing sedation and hypotension). The direct i.v.-injection of undiluted solution is contraindicated (massive fall in blood pressure, cardiovascular collapse), for i.v.-infusion of dilutions the (hospitalized) patient should be lying and the infusion rate should be as slow as possible. Afterwards the patient should rest in the lying position for at least 30 minutes. [edit] Necessary examinations and laboratory checks during treatment All patients treated with chlorpromazine on a long-term-basis should have regularly checked their blood-pressure, pulse rate, laboratory-tests (liver function tests, kidney-values, blood cell counts including differenciated white blood counts, counts of red blood cells and thrombocytes), ECG and EEG. The frequency of all checks should be determined for the individual patient and may be done in shorter intervals during the first 3 months of treatment and less often afterwards. Some side effects seem to appear more frequently during the first months of therapy (sedation, hypotension, liver damage) while others do not (e.g. tardive dyskinesia). [edit] Discontinuation of treatment Also, in regular intervals the treating physician should evaluate whether continued treatment is needed. If not, the drug should never be stopped suddenly, due to very unpleasant 'withdrawal-symptoms', such as agitation, sleeplessness, states of anxiety, etc. However, these symptoms definitely do not indicate psychological or physical dependence. The dose should rather be slowly tapered down at a rate of approximately 20–25% per week or even slower to avoid the aforementioned bothersome symptoms. Chlorpromazine is derived from phenothiazine, and has an aliphatic side chain, typical for low to middle potency neuroleptics. The oral bioavailability is estimated to be 30–50% due to extensive first pass metabolization in the liver. Its elimination-halflife is 16–30 hours. It has many active metabolites (approx. 75 different ones) with greatly varying halflives and own pharmacological profiles. The CYP-450 isoenzymes 1A2 and 2D6 are needed for metabolization of chlorpromazine and the subtype 2D6 is inhibited by chlorpromazine (NB: possible interactions with other drugs). Answered by Liz Lacks 2 years ago.


What are some reasons why a person might be prescribed 200 mg of thorazine?
...from a medical prospective. Asked by Keturah Niemela 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Charissa Touchet 2 years ago.

The warding off man or woman will have angry through a comment the have shyed away from man or woman made. The warding off man or woman will have a few prejudice towards the have shyed away from man or woman. The have shyed away from man or woman might remind the warding off man or woman of an ex-boyfriend or ex-female friend or different man or woman who the warding off man or woman desires to omit. Maybe anybody instructed the warding off man or woman that the have shyed away from man or woman does not like him/her. But the object is, why do you care? Answered by Alan Werger 2 years ago.

It's an anti-psychotic, for bipolar disorder or schizophrenia. Answered by Tabitha Barnes 2 years ago.


What is Thorazine, Lorazepam and Compazine? What are they used for?
Asked by Meghann Manigo 2 years ago.

Chlorpromazine is classified as a low-potency typical antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of bipolar disorder, as well as amphetamine-induced psychoses. Low-potency antipsychotics have more anticholinergic side effects, such as dry mouth, sedation, and constipation, and lower rates of extrapyramidal side effects, while high-potency antipsychotics (such as haloperidol) have the reverse profile. Chlorpromazine has also been used in porphyria and as part of tetanus treatment. It still is recommended for short-term management of severe anxiety and psychotic aggression. Resistant and severe hiccups, severe nausea/emesis, and preanesthetic conditioning are other uses. Symptoms of delirium in medically-hospitalized AIDS patients have been effectively treated with low doses of chlorpromazine Answered by Darryl Washpun 2 years ago.

They are antipsycotic drugs used to treat manic depression, schizophrenia Answered by Violeta Chamlee 2 years ago.


Is 25 mg of Thorazine safe to take for anxiety?
Asked by Aide Mcfall 2 years ago.

Thorazine, at 25 mg, is used for chronic hiccups, nausea and vomitting, sedation before surgery, and sometimes anxiety. However, it is anti-psychotic, a tranquilizer, and very old school, so if it was not prescribed to you, don't tske it. This may just be a question of general curiosity, but if you need meds for anxiety, there are more suitable ones than thorazine. See the doc. to get the right one for you! Answered by Beatris Pavlat 2 years ago.

Thorazine is not an anti-anxiety drug. It is an antipsychotic drug. Please do not take ANY prescription medication unless under the direction of your personal physician. Answered by Mechelle Ellzey 2 years ago.

I think I would speak to a Pharmacist before listening to someone on Yahoo answers. Answered by Kristine Linsenmayer 2 years ago.

The potential for causing chronic movement disorders makes it far from ideal. Answered by Johnna Pasho 2 years ago.

It has more potential side effects than newer drugs. For example, seizures, heat exhaustion, drowsiness. Answered by Joanie Pestoni 2 years ago.


Is it true that Thorazine is as dangerous and the Psychiatric critics say it is?
From Psychiatric critics they criticize Thorazine a lot and say it messes people up like Lobotomy. Here is an example website criticizing Thorazine: http://www.sntp.net/drugs/thorazine.htm Asked by Gertrudis Estess 2 years ago.

Thorazine is no more dangerous than the others. Staying on it for too long can lead to specific complications, which is true with other anti-psychotics. It isn't used as much these days, but it is still a consideration for some people. It's OK to critisize thorazine, but no more so than for other such drugs. Answered by Otelia Bonamico 2 years ago.

Wow! Normally, I don't answer questions that want to learn more and more detail. As in your case, because they require a long process, and it is the risk of not solve all of yours problems. I would suggest to proceed analytically with the help of keywords to be included in Yahoo! From what you climb, narrowing the field with new keywords, until you will be fully satisfied. good luck! Answered by Julissa Fromdahl 2 years ago.


Is Thorazine(Chlorpromazine) an older anti-psychotic?
I was prescribed this recently for Bipolar Disorder. Is it an older anti-psychotic?Thanks Asked by Jordon Amara 2 years ago.

Thorazine was one of the first anti-psychotics, created in 1950. It is still occasionally used in the treatment of schizophrenia and bipolar disorder, but not as often as it was a few decades ago. It's a low potency anti-psychotic, so there is a lower chance of experiencing unwanted side effects. Answered by Luna Vento 2 years ago.


How long will thorazine take to get in my urine stream?
i want to take a thorazine but i have a drug test at 10:00am and dont know what time yo take it so i can pass the drug test and still take it tonight Asked by Rose Olten 2 years ago.

To my understanding, Thorazine is an anti-psychotic medication. It's not typically screened for on a drug test. However, if you do register with a false positive in another drug category as a result of this medication, all you have to do is show proof of a prescription and you're in the clear. Thorazine is excreted primarily through the urine and has a half-life from 10 to 40 hours. Answered by Golda Payden 2 years ago.

You can't wait until after the test to take it - just to be on the safe side? Answered by Patria Darnstaedt 2 years ago.


About Thorazine/Largactil?
I have read alot about this drug, but I would like to hear from somone that has actually used it, or someone who knows someone who has used it.How sedating/tranquilizing is it? What are the main side-effects, and what pills do I need to counteract these side-effects? Asked by Shea Pedulla 2 years ago.

About counteraction - I'm not sure. You'd have to take it to know if you'd have any counteractions, first. I took Thorazine for about a month for sleep. It never made me tired. It would, however, keep me asleep for 8-12 hrs once I laid down and fell asleep. Not a good drug if you need to be knocked out (in my opinion). I'm sure you've heard it called 'the chemical lobotomy'. I didn't feel like it erased too much of my personality, and I was still heavily addicted to drugs and it never made me seek/want drugs less. I really don't remember much from taking it. I snorted it once, and it burned like a SOB, but it knocked me out right away. Answered by Ellyn Girote 2 years ago.


Mrs S. has been taking Thorazine for about 1 year?
She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the... Asked by Rutha Brereton 2 years ago.

She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the nursing diagnosis for this patient. a) What interventions would be used for this diagnosis? b) How would the nurse evaluate the outcome of the interventions? Answered by Lilliana Fiebich 2 years ago.

thorazine is bound to have more severe side effects.. clozaril is an atypical antipsychotic drug, so it will be LESS likely to cause tardive dyskenesia and akathisia and other similarly devastating side effects (thanks to its anticholinergic properties). However, there is recent evidence that such drugs may increase the likelihood of metabolic disturbances (leading to diabetes) and cardiovascular disease. There are also sexual functioning side effects, but that is common to many psychotropic meds...Note that slow titration of dosing of Clozaril significantly decreases the likelihood of orthostatic hypotension, so the switch is right on the money for this mrs. s....... I would say the switch from thorazine to clozaril is not a bad idea. I have no idea what you mean by "knowledge deficit" and "nursing diagnosis", I'm coming from a clinical psych perspective, but hope this helps! Answered by Shemeka Rippelmeyer 2 years ago.


What is thorazine used for?
Asked by Edwina Laizure 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Anderson Statzer 2 years ago.

Thorazine Uses Answered by Richard Ollison 2 years ago.

I don't know all of its uses, but I was given Thorazine for migraines. Answered by Darlena Iwanyszyn 2 years ago.

It is a old anti-psychotic. They use to use it a lot in psychiatric hospitals to calm down patients. It is also used for migraines at times. Answered by Frances Bugg 2 years ago.

To mess with kids minds! Answered by Alisa Scarborough 2 years ago.

PAIN!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!... Answered by Royce Berlingeri 2 years ago.

Chlorpromazine was the first antipsychotic drug, used during the 1950s and 1960s. Used as chlorpromazine hydrochloride and sold under the tradenames Largactil® and Thorazine®, it has sedative, hypotensive and antiemetic properties as well as anticholinergic and antidopaminergic effects. It has also anxiolytic (alleviation of anxiety) properties. Today, chlorpromazine is considered a typical antipsychotic. Chlorpromazine acts as an antagonist (blocking agent) on different postsynaptic receptors: on dopaminergic-receptors (subtypes D1, D2, D3 and D4, different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), on alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism—controversial), and on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side effects). Additionally, chlorpromazine is a weak presynaptic inhibitor of dopamine reuptake, which may lead to (mild) antidepressive and antiparkinsonian effects. This action could also account for psychomotor agitation and amplification of psychosis (very rarely noted in clinical use). [edit] Peripheral Antagonist to H1 receptors (antiallergic effects), H2 receptors (reduction of forming of gastric juice), M1/M2-receptors (dry mouth, reduction in forming of gastric juice) and some 5-HT receptors (different anti-allergic/gastrointestinal actions). Because it acts on so many receptors, chlorpromazine is often referred to as "dirty drug", whereas the atypical neuroleptic amisulpride for example acts only on central D2/D3-receptors and is therefore a "clean drug". This distinction is not a positive or negative value judgment on the drug, rather it is a neutral term which merely describes the agent's relative pharmacology. [edit] History The drug had been developed by Laboratoires Rhône-Poulenc in 1950 but they sold the rights in 1952 to Smith-Kline & French (today's GlaxoSmithKline). The drug was being sold as an antiemetic when its other use was noted. Smith-Kline was quick to encourage clinical trials and in 1954 the drug was approved in the US for psychiatric treatment. Over 100 million people were treated but the popularity of the drug fell from the late 1960s as the severe extrapyramidal side effects and tardive dyskinesia became more of a concern. From chlorpromazine a number of other similar neuroleptics were developed (e.g. triflupromazine, trifluoperazine). Previously used as an antihistamine and antiemetic its effects on mental state were first reported by the French doctor Henri Laborit in 1951 or 1952 (different sources) as sedation without narcosis. It became possible to cause 'artificial hibernation' in patients, if used as a cocktail together with pethidine and hydergine. Patients with shock, severe trauma or burns, become, if treated so, sedated, without anxiety and unreponsive/indifferent to painful external stimuli like minor surgical interventions. It was first used for psychiatric patients by Pierre Deniker and Jean Delay in 1953. Drug treatment with chlorpromazine went beyond simple sedation with patients showing improvements in thinking and emotional behaviour. Ironically, the antipsychotic properties of chlorpromazine appear to be unrelated to its sedative properties. During long term therapy some tolerance to the sedation effect develops. Chlorpromazine substituted and eclipsed the old therapies of electro- and insulin shocks and other methods such as psychosurgical means (lobotomy) causing permanent brain injury. Chlorpromazine has given approximately 70% of all schizophrenic patients a complete remission or near so and a normal, gainful human life. Before the era of neuroleptics, starting with chlorpromazine, positive long-term results for psychotic patients were only 20%. [edit] Side effects Side effects of chlorpromazine are typical of early generation neuroleptics. They include extrapyramidal side effects such as tardive dyskinesia and akathisia. A particularly severe side effect is the neuroleptic malignant syndrome which occurs in approximately 0.05% and can be fatal. Also, chlorpromazine may lower seizure threshold. Additional side effects include dry mouth, increased appetite with weight gain, constipation and urinary retention. Glucose tolerance may be impaired. An allergic skin rash and photosensitivity may occur. Other important and severe side effects are a strong reduction in the number of white blood cells, referred to as leukopenia, or, in extreme cases, even agranulocytosis may result, which may lead to death via uncontrollable infections and/or sepsis. Chlorpromazine is the neuroleptic drug with the highest rates (0.5% to 1%) of liver toxicity of the cholestatic type. The sedation effect combined with indifference to physical stimuli, anecdotally known as the "thorazine shuffle," has long been associated with the drug. The image of psychiatric patients staggering mute around a padded cell has earned those particular side effects a place in mainstream pop culture. [edit] Interactions Chlorpromazine intensifies the central depressive action of drugs with such activity (tranquilizers, barbiturates, narcotics, antihistamines, OTC-antiemetics etc.). A dose reduction of chlorpromazine or the other drug may be necessary. Chlorpromazine also intensifies the actions and undesired side effects of antihypertensive medications and anticholinergic drugs. The combination of chlorpromazine with other antipsychotics may result in increased central depression, hypotension and extrapyramidal side effects, but may sometimes enhance the clinical results of therapy. The anti-worm drug (antihelminthic) piperazine may intensify extrapyramidal side effects. In general, all neuroleptics may lead to seizures in combination with tramadol (Ultram). Chlorpromazine may increase the insulin needs of diabetic patients. Drugs like SSRIs, St. John's Wort and barbiturates can inhibit various CYP-isoenzymes such as CYP2D6, needed for metabolization of chlorpromazine and/or its metabolites. Theoretically, this should increase the half-lives of chlorpromazine and possibly its metabolites, dosing changes necessary. The exact clinical significance of this enzyme induction and its therapeutic consequences are unknown at present time and remain to be evaluated. [edit] Uses [edit] Common uses [edit] As an antipsychotic The use of chlorpromazine has been primarily replaced by newer generation of atypical antipsychotics which have an improved side effect profile. Chlorpromazine is classified as a low- to moderate-potency antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of manic depression as well as amphetamine-induced psychoses. Chlorpromazine formerly was the drug of choice to treat LSD (and other psychedelic/hallucinogen) intoxication in a hospital setting, resulting in it gaining an erroneous reputation as the LSD "antidote". Now haloperidol is more commonly used in such situations. [edit] Other uses It has also been used in porphyria, as part of tetanus treatment and for behavioral problems in children. It still is well recommended for short term management of severe anxiety and aggressive episodes. Resistant and severe hiccups, severe nausea/emesis and preanesthetic conditioning have been other indications in the past. It can be used to treat amphetamine overdose. [1] [edit] Off-label and controversial uses Chlorpromazine is occasionally used off-label for treatment of severe migraine. Sometimes it is used in small doses to improve nausea/emesis opioid-treated cancer patients encounter and to intensify and prolong the analgesic action of the opioids given. Interestingly, it remains controversial whether or not chlorpromazine has its own analgesic properties. Analgesic properties may result from a central action on the hypothalamus; the patient may feel the pain much less than before. Other mechanisms may be an interaction with opioid receptors centrally and/or in the spinal cord. Some experts on the contrary say that chlorpromazine, like other phenothiazines, may even have antianalgesic properties. Chlorpromazine has been proposed as useful in newborns for the treatment of opioid withdrawal, if the mother was opioid-dependent. The latter indication remains highly controversial. Chlorpromazine, as well as other neuroleptics, may also be used to alleviate the symptoms of alcohol withdrawal (chlorpromazine may lower the seizure-threshold in alcoholics). It has a unique action in cholera, reducing the loss of water by approximately 30%. In Germany, the brand of chlorpromazine drug Propaphenin® has additional indications for insomnia and itching skin disease. [edit] Veterinary uses Chlorpromazine is primarily used as an antiemetic in dogs and cats. It is also sometimes used as a preanesthetic and muscle relaxant in cattle, swine, sheep, and goats. It is generally contraindicated for use with horses, due to a high incidence of ataxia and altered mentation. [edit] Dosage In any case, use is determined by an attending physician. The following information is intended to serve as a guideline: A wide range is covered from 25 mg oral or intramuscular for mild sedation, every 8 hours, up to 100 mg every 6 hours for severely disturbed patients. Different qualified sources give 800 mg/day to 1,200 mg/day as highest dose. At least there is one small clinical trial in treatment-resistant patients with a daily dose of 1,200 mg chlorpromazine (and 4 mg Benztropine to counteract early extrapyramidal side effects, which were anticipated with this unusual high chlorpromazine dose). Initial doses should be low and be increased gradually. It is recommended that most of the daily dose (e.g. 2/3) is given at bedtime for maximum hypnotic activity and minimal daytime sedation and hypotension. In the USA there are controlled release forms of Thorazine (e.g. 300 mg). After the individual dose is well established, such a CR capsule can be given with the evening meal as a single dose, covering the next 24 hours. The lowest dosage compatible with good therapeutic effect should be given. Dosage in ambulatory patients should be particularly low (minimizing sedation and hypotension). The direct i.v.-injection of undiluted solution is contraindicated (massive fall in blood pressure, cardiovascular collapse), for i.v.-infusion of dilutions the (hospitalized) patient should be lying and the infusion rate should be as slow as possible. Afterwards the patient should rest in the lying position for at least 30 minutes. [edit] Necessary examinations and laboratory checks during treatment All patients treated with chlorpromazine on a long-term-basis should have regularly checked their blood-pressure, pulse rate, laboratory-tests (liver function tests, kidney-values, blood cell counts including differenciated white blood counts, counts of red blood cells and thrombocytes), ECG and EEG. The frequency of all checks should be determined for the individual patient and may be done in shorter intervals during the first 3 months of treatment and less often afterwards. Some side effects seem to appear more frequently during the first months of therapy (sedation, hypotension, liver damage) while others do not (e.g. tardive dyskinesia). [edit] Discontinuation of treatment Also, in regular intervals the treating physician should evaluate whether continued treatment is needed. If not, the drug should never be stopped suddenly, due to very unpleasant 'withdrawal-symptoms', such as agitation, sleeplessness, states of anxiety, etc. However, these symptoms definitely do not indicate psychological or physical dependence. The dose should rather be slowly tapered down at a rate of approximately 20–25% per week or even slower to avoid the aforementioned bothersome symptoms. Chlorpromazine is derived from phenothiazine, and has an aliphatic side chain, typical for low to middle potency neuroleptics. The oral bioavailability is estimated to be 30–50% due to extensive first pass metabolization in the liver. Its elimination-halflife is 16–30 hours. It has many active metabolites (approx. 75 different ones) with greatly varying halflives and own pharmacological profiles. The CYP-450 isoenzymes 1A2 and 2D6 are needed for metabolization of chlorpromazine and the subtype 2D6 is inhibited by chlorpromazine (NB: possible interactions with other drugs). Answered by Tawny Unick 2 years ago.


What are some reasons why a person might be prescribed 200 mg of thorazine?
...from a medical prospective. Asked by Ayanna Zangari 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Lesley Griglen 2 years ago.

The warding off man or woman will have angry through a comment the have shyed away from man or woman made. The warding off man or woman will have a few prejudice towards the have shyed away from man or woman. The have shyed away from man or woman might remind the warding off man or woman of an ex-boyfriend or ex-female friend or different man or woman who the warding off man or woman desires to omit. Maybe anybody instructed the warding off man or woman that the have shyed away from man or woman does not like him/her. But the object is, why do you care? Answered by Stephenie Clizbe 2 years ago.

It's an anti-psychotic, for bipolar disorder or schizophrenia. Answered by Stanford Deakyne 2 years ago.


What is Thorazine, Lorazepam and Compazine? What are they used for?
Asked by Windy Malabe 2 years ago.

Chlorpromazine is classified as a low-potency typical antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of bipolar disorder, as well as amphetamine-induced psychoses. Low-potency antipsychotics have more anticholinergic side effects, such as dry mouth, sedation, and constipation, and lower rates of extrapyramidal side effects, while high-potency antipsychotics (such as haloperidol) have the reverse profile. Chlorpromazine has also been used in porphyria and as part of tetanus treatment. It still is recommended for short-term management of severe anxiety and psychotic aggression. Resistant and severe hiccups, severe nausea/emesis, and preanesthetic conditioning are other uses. Symptoms of delirium in medically-hospitalized AIDS patients have been effectively treated with low doses of chlorpromazine Answered by Torri Daub 2 years ago.

They are antipsycotic drugs used to treat manic depression, schizophrenia Answered by Tamika Lobingier 2 years ago.


Is 25 mg of Thorazine safe to take for anxiety?
Asked by Katherin Strandberg 2 years ago.

Thorazine, at 25 mg, is used for chronic hiccups, nausea and vomitting, sedation before surgery, and sometimes anxiety. However, it is anti-psychotic, a tranquilizer, and very old school, so if it was not prescribed to you, don't tske it. This may just be a question of general curiosity, but if you need meds for anxiety, there are more suitable ones than thorazine. See the doc. to get the right one for you! Answered by Tina Haigwood 2 years ago.

Thorazine is not an anti-anxiety drug. It is an antipsychotic drug. Please do not take ANY prescription medication unless under the direction of your personal physician. Answered by Dagmar Ester 2 years ago.

I think I would speak to a Pharmacist before listening to someone on Yahoo answers. Answered by Chastity Lowder 2 years ago.

The potential for causing chronic movement disorders makes it far from ideal. Answered by Irma Brazel 2 years ago.

It has more potential side effects than newer drugs. For example, seizures, heat exhaustion, drowsiness. Answered by Ignacio Yokum 2 years ago.


Is it true that Thorazine is as dangerous and the Psychiatric critics say it is?
From Psychiatric critics they criticize Thorazine a lot and say it messes people up like Lobotomy. Here is an example website criticizing Thorazine: http://www.sntp.net/drugs/thorazine.htm Asked by Blake Rygalski 2 years ago.

Thorazine is no more dangerous than the others. Staying on it for too long can lead to specific complications, which is true with other anti-psychotics. It isn't used as much these days, but it is still a consideration for some people. It's OK to critisize thorazine, but no more so than for other such drugs. Answered by Jesusa Villalouos 2 years ago.

Wow! Normally, I don't answer questions that want to learn more and more detail. As in your case, because they require a long process, and it is the risk of not solve all of yours problems. I would suggest to proceed analytically with the help of keywords to be included in Yahoo! From what you climb, narrowing the field with new keywords, until you will be fully satisfied. good luck! Answered by Aretha Summars 2 years ago.


Is Thorazine(Chlorpromazine) an older anti-psychotic?
I was prescribed this recently for Bipolar Disorder. Is it an older anti-psychotic?Thanks Asked by Daisy Parkman 2 years ago.

Thorazine was one of the first anti-psychotics, created in 1950. It is still occasionally used in the treatment of schizophrenia and bipolar disorder, but not as often as it was a few decades ago. It's a low potency anti-psychotic, so there is a lower chance of experiencing unwanted side effects. Answered by Dorthea Roback 2 years ago.


How long will thorazine take to get in my urine stream?
i want to take a thorazine but i have a drug test at 10:00am and dont know what time yo take it so i can pass the drug test and still take it tonight Asked by Lincoln Jalonen 2 years ago.

To my understanding, Thorazine is an anti-psychotic medication. It's not typically screened for on a drug test. However, if you do register with a false positive in another drug category as a result of this medication, all you have to do is show proof of a prescription and you're in the clear. Thorazine is excreted primarily through the urine and has a half-life from 10 to 40 hours. Answered by Darnell Susan 2 years ago.

You can't wait until after the test to take it - just to be on the safe side? Answered by Chad Artale 2 years ago.


About Thorazine/Largactil?
I have read alot about this drug, but I would like to hear from somone that has actually used it, or someone who knows someone who has used it.How sedating/tranquilizing is it? What are the main side-effects, and what pills do I need to counteract these side-effects? Asked by Van Trojahn 2 years ago.

About counteraction - I'm not sure. You'd have to take it to know if you'd have any counteractions, first. I took Thorazine for about a month for sleep. It never made me tired. It would, however, keep me asleep for 8-12 hrs once I laid down and fell asleep. Not a good drug if you need to be knocked out (in my opinion). I'm sure you've heard it called 'the chemical lobotomy'. I didn't feel like it erased too much of my personality, and I was still heavily addicted to drugs and it never made me seek/want drugs less. I really don't remember much from taking it. I snorted it once, and it burned like a SOB, but it knocked me out right away. Answered by Luella Shellhaas 2 years ago.


Mrs S. has been taking Thorazine for about 1 year?
She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the... Asked by Apolonia Mcconnal 2 years ago.

She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the nursing diagnosis for this patient. a) What interventions would be used for this diagnosis? b) How would the nurse evaluate the outcome of the interventions? Answered by Sarah Clesca 2 years ago.

thorazine is bound to have more severe side effects.. clozaril is an atypical antipsychotic drug, so it will be LESS likely to cause tardive dyskenesia and akathisia and other similarly devastating side effects (thanks to its anticholinergic properties). However, there is recent evidence that such drugs may increase the likelihood of metabolic disturbances (leading to diabetes) and cardiovascular disease. There are also sexual functioning side effects, but that is common to many psychotropic meds...Note that slow titration of dosing of Clozaril significantly decreases the likelihood of orthostatic hypotension, so the switch is right on the money for this mrs. s....... I would say the switch from thorazine to clozaril is not a bad idea. I have no idea what you mean by "knowledge deficit" and "nursing diagnosis", I'm coming from a clinical psych perspective, but hope this helps! Answered by Dudley Halgrimson 2 years ago.


What is thorazine used for?
Asked by Napoleon Scoggan 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Camille Ragsdale 2 years ago.

Thorazine Uses Answered by Noel Frederic 2 years ago.

I don't know all of its uses, but I was given Thorazine for migraines. Answered by Jefferson Ollig 2 years ago.

It is a old anti-psychotic. They use to use it a lot in psychiatric hospitals to calm down patients. It is also used for migraines at times. Answered by Carman Weyker 2 years ago.

To mess with kids minds! Answered by Miriam Ichikawa 2 years ago.

PAIN!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!... Answered by Corrina Apa 2 years ago.

Chlorpromazine was the first antipsychotic drug, used during the 1950s and 1960s. Used as chlorpromazine hydrochloride and sold under the tradenames Largactil® and Thorazine®, it has sedative, hypotensive and antiemetic properties as well as anticholinergic and antidopaminergic effects. It has also anxiolytic (alleviation of anxiety) properties. Today, chlorpromazine is considered a typical antipsychotic. Chlorpromazine acts as an antagonist (blocking agent) on different postsynaptic receptors: on dopaminergic-receptors (subtypes D1, D2, D3 and D4, different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), on alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism—controversial), and on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side effects). Additionally, chlorpromazine is a weak presynaptic inhibitor of dopamine reuptake, which may lead to (mild) antidepressive and antiparkinsonian effects. This action could also account for psychomotor agitation and amplification of psychosis (very rarely noted in clinical use). [edit] Peripheral Antagonist to H1 receptors (antiallergic effects), H2 receptors (reduction of forming of gastric juice), M1/M2-receptors (dry mouth, reduction in forming of gastric juice) and some 5-HT receptors (different anti-allergic/gastrointestinal actions). Because it acts on so many receptors, chlorpromazine is often referred to as "dirty drug", whereas the atypical neuroleptic amisulpride for example acts only on central D2/D3-receptors and is therefore a "clean drug". This distinction is not a positive or negative value judgment on the drug, rather it is a neutral term which merely describes the agent's relative pharmacology. [edit] History The drug had been developed by Laboratoires Rhône-Poulenc in 1950 but they sold the rights in 1952 to Smith-Kline & French (today's GlaxoSmithKline). The drug was being sold as an antiemetic when its other use was noted. Smith-Kline was quick to encourage clinical trials and in 1954 the drug was approved in the US for psychiatric treatment. Over 100 million people were treated but the popularity of the drug fell from the late 1960s as the severe extrapyramidal side effects and tardive dyskinesia became more of a concern. From chlorpromazine a number of other similar neuroleptics were developed (e.g. triflupromazine, trifluoperazine). Previously used as an antihistamine and antiemetic its effects on mental state were first reported by the French doctor Henri Laborit in 1951 or 1952 (different sources) as sedation without narcosis. It became possible to cause 'artificial hibernation' in patients, if used as a cocktail together with pethidine and hydergine. Patients with shock, severe trauma or burns, become, if treated so, sedated, without anxiety and unreponsive/indifferent to painful external stimuli like minor surgical interventions. It was first used for psychiatric patients by Pierre Deniker and Jean Delay in 1953. Drug treatment with chlorpromazine went beyond simple sedation with patients showing improvements in thinking and emotional behaviour. Ironically, the antipsychotic properties of chlorpromazine appear to be unrelated to its sedative properties. During long term therapy some tolerance to the sedation effect develops. Chlorpromazine substituted and eclipsed the old therapies of electro- and insulin shocks and other methods such as psychosurgical means (lobotomy) causing permanent brain injury. Chlorpromazine has given approximately 70% of all schizophrenic patients a complete remission or near so and a normal, gainful human life. Before the era of neuroleptics, starting with chlorpromazine, positive long-term results for psychotic patients were only 20%. [edit] Side effects Side effects of chlorpromazine are typical of early generation neuroleptics. They include extrapyramidal side effects such as tardive dyskinesia and akathisia. A particularly severe side effect is the neuroleptic malignant syndrome which occurs in approximately 0.05% and can be fatal. Also, chlorpromazine may lower seizure threshold. Additional side effects include dry mouth, increased appetite with weight gain, constipation and urinary retention. Glucose tolerance may be impaired. An allergic skin rash and photosensitivity may occur. Other important and severe side effects are a strong reduction in the number of white blood cells, referred to as leukopenia, or, in extreme cases, even agranulocytosis may result, which may lead to death via uncontrollable infections and/or sepsis. Chlorpromazine is the neuroleptic drug with the highest rates (0.5% to 1%) of liver toxicity of the cholestatic type. The sedation effect combined with indifference to physical stimuli, anecdotally known as the "thorazine shuffle," has long been associated with the drug. The image of psychiatric patients staggering mute around a padded cell has earned those particular side effects a place in mainstream pop culture. [edit] Interactions Chlorpromazine intensifies the central depressive action of drugs with such activity (tranquilizers, barbiturates, narcotics, antihistamines, OTC-antiemetics etc.). A dose reduction of chlorpromazine or the other drug may be necessary. Chlorpromazine also intensifies the actions and undesired side effects of antihypertensive medications and anticholinergic drugs. The combination of chlorpromazine with other antipsychotics may result in increased central depression, hypotension and extrapyramidal side effects, but may sometimes enhance the clinical results of therapy. The anti-worm drug (antihelminthic) piperazine may intensify extrapyramidal side effects. In general, all neuroleptics may lead to seizures in combination with tramadol (Ultram). Chlorpromazine may increase the insulin needs of diabetic patients. Drugs like SSRIs, St. John's Wort and barbiturates can inhibit various CYP-isoenzymes such as CYP2D6, needed for metabolization of chlorpromazine and/or its metabolites. Theoretically, this should increase the half-lives of chlorpromazine and possibly its metabolites, dosing changes necessary. The exact clinical significance of this enzyme induction and its therapeutic consequences are unknown at present time and remain to be evaluated. [edit] Uses [edit] Common uses [edit] As an antipsychotic The use of chlorpromazine has been primarily replaced by newer generation of atypical antipsychotics which have an improved side effect profile. Chlorpromazine is classified as a low- to moderate-potency antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of manic depression as well as amphetamine-induced psychoses. Chlorpromazine formerly was the drug of choice to treat LSD (and other psychedelic/hallucinogen) intoxication in a hospital setting, resulting in it gaining an erroneous reputation as the LSD "antidote". Now haloperidol is more commonly used in such situations. [edit] Other uses It has also been used in porphyria, as part of tetanus treatment and for behavioral problems in children. It still is well recommended for short term management of severe anxiety and aggressive episodes. Resistant and severe hiccups, severe nausea/emesis and preanesthetic conditioning have been other indications in the past. It can be used to treat amphetamine overdose. [1] [edit] Off-label and controversial uses Chlorpromazine is occasionally used off-label for treatment of severe migraine. Sometimes it is used in small doses to improve nausea/emesis opioid-treated cancer patients encounter and to intensify and prolong the analgesic action of the opioids given. Interestingly, it remains controversial whether or not chlorpromazine has its own analgesic properties. Analgesic properties may result from a central action on the hypothalamus; the patient may feel the pain much less than before. Other mechanisms may be an interaction with opioid receptors centrally and/or in the spinal cord. Some experts on the contrary say that chlorpromazine, like other phenothiazines, may even have antianalgesic properties. Chlorpromazine has been proposed as useful in newborns for the treatment of opioid withdrawal, if the mother was opioid-dependent. The latter indication remains highly controversial. Chlorpromazine, as well as other neuroleptics, may also be used to alleviate the symptoms of alcohol withdrawal (chlorpromazine may lower the seizure-threshold in alcoholics). It has a unique action in cholera, reducing the loss of water by approximately 30%. In Germany, the brand of chlorpromazine drug Propaphenin® has additional indications for insomnia and itching skin disease. [edit] Veterinary uses Chlorpromazine is primarily used as an antiemetic in dogs and cats. It is also sometimes used as a preanesthetic and muscle relaxant in cattle, swine, sheep, and goats. It is generally contraindicated for use with horses, due to a high incidence of ataxia and altered mentation. [edit] Dosage In any case, use is determined by an attending physician. The following information is intended to serve as a guideline: A wide range is covered from 25 mg oral or intramuscular for mild sedation, every 8 hours, up to 100 mg every 6 hours for severely disturbed patients. Different qualified sources give 800 mg/day to 1,200 mg/day as highest dose. At least there is one small clinical trial in treatment-resistant patients with a daily dose of 1,200 mg chlorpromazine (and 4 mg Benztropine to counteract early extrapyramidal side effects, which were anticipated with this unusual high chlorpromazine dose). Initial doses should be low and be increased gradually. It is recommended that most of the daily dose (e.g. 2/3) is given at bedtime for maximum hypnotic activity and minimal daytime sedation and hypotension. In the USA there are controlled release forms of Thorazine (e.g. 300 mg). After the individual dose is well established, such a CR capsule can be given with the evening meal as a single dose, covering the next 24 hours. The lowest dosage compatible with good therapeutic effect should be given. Dosage in ambulatory patients should be particularly low (minimizing sedation and hypotension). The direct i.v.-injection of undiluted solution is contraindicated (massive fall in blood pressure, cardiovascular collapse), for i.v.-infusion of dilutions the (hospitalized) patient should be lying and the infusion rate should be as slow as possible. Afterwards the patient should rest in the lying position for at least 30 minutes. [edit] Necessary examinations and laboratory checks during treatment All patients treated with chlorpromazine on a long-term-basis should have regularly checked their blood-pressure, pulse rate, laboratory-tests (liver function tests, kidney-values, blood cell counts including differenciated white blood counts, counts of red blood cells and thrombocytes), ECG and EEG. The frequency of all checks should be determined for the individual patient and may be done in shorter intervals during the first 3 months of treatment and less often afterwards. Some side effects seem to appear more frequently during the first months of therapy (sedation, hypotension, liver damage) while others do not (e.g. tardive dyskinesia). [edit] Discontinuation of treatment Also, in regular intervals the treating physician should evaluate whether continued treatment is needed. If not, the drug should never be stopped suddenly, due to very unpleasant 'withdrawal-symptoms', such as agitation, sleeplessness, states of anxiety, etc. However, these symptoms definitely do not indicate psychological or physical dependence. The dose should rather be slowly tapered down at a rate of approximately 20–25% per week or even slower to avoid the aforementioned bothersome symptoms. Chlorpromazine is derived from phenothiazine, and has an aliphatic side chain, typical for low to middle potency neuroleptics. The oral bioavailability is estimated to be 30–50% due to extensive first pass metabolization in the liver. Its elimination-halflife is 16–30 hours. It has many active metabolites (approx. 75 different ones) with greatly varying halflives and own pharmacological profiles. The CYP-450 isoenzymes 1A2 and 2D6 are needed for metabolization of chlorpromazine and the subtype 2D6 is inhibited by chlorpromazine (NB: possible interactions with other drugs). Answered by Leonie Wingeier 2 years ago.


What are some reasons why a person might be prescribed 200 mg of thorazine?
...from a medical prospective. Asked by Berniece Wegleitner 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Ludie Becwar 2 years ago.

The warding off man or woman will have angry through a comment the have shyed away from man or woman made. The warding off man or woman will have a few prejudice towards the have shyed away from man or woman. The have shyed away from man or woman might remind the warding off man or woman of an ex-boyfriend or ex-female friend or different man or woman who the warding off man or woman desires to omit. Maybe anybody instructed the warding off man or woman that the have shyed away from man or woman does not like him/her. But the object is, why do you care? Answered by Clare Bronsky 2 years ago.

It's an anti-psychotic, for bipolar disorder or schizophrenia. Answered by Magan Dobes 2 years ago.


What is Thorazine, Lorazepam and Compazine? What are they used for?
Asked by Patrick Dees 2 years ago.

Chlorpromazine is classified as a low-potency typical antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of bipolar disorder, as well as amphetamine-induced psychoses. Low-potency antipsychotics have more anticholinergic side effects, such as dry mouth, sedation, and constipation, and lower rates of extrapyramidal side effects, while high-potency antipsychotics (such as haloperidol) have the reverse profile. Chlorpromazine has also been used in porphyria and as part of tetanus treatment. It still is recommended for short-term management of severe anxiety and psychotic aggression. Resistant and severe hiccups, severe nausea/emesis, and preanesthetic conditioning are other uses. Symptoms of delirium in medically-hospitalized AIDS patients have been effectively treated with low doses of chlorpromazine Answered by Yon Henzel 2 years ago.

They are antipsycotic drugs used to treat manic depression, schizophrenia Answered by Nellie Lessly 2 years ago.


Is 25 mg of Thorazine safe to take for anxiety?
Asked by Amanda Beckles 2 years ago.

Thorazine, at 25 mg, is used for chronic hiccups, nausea and vomitting, sedation before surgery, and sometimes anxiety. However, it is anti-psychotic, a tranquilizer, and very old school, so if it was not prescribed to you, don't tske it. This may just be a question of general curiosity, but if you need meds for anxiety, there are more suitable ones than thorazine. See the doc. to get the right one for you! Answered by Lashunda Hirschberg 2 years ago.

Thorazine is not an anti-anxiety drug. It is an antipsychotic drug. Please do not take ANY prescription medication unless under the direction of your personal physician. Answered by Chana Wewerka 2 years ago.

I think I would speak to a Pharmacist before listening to someone on Yahoo answers. Answered by Melani Palay 2 years ago.

The potential for causing chronic movement disorders makes it far from ideal. Answered by Gilberte Evinger 2 years ago.

It has more potential side effects than newer drugs. For example, seizures, heat exhaustion, drowsiness. Answered by Isreal Kaluna 2 years ago.


Is it true that Thorazine is as dangerous and the Psychiatric critics say it is?
From Psychiatric critics they criticize Thorazine a lot and say it messes people up like Lobotomy. Here is an example website criticizing Thorazine: http://www.sntp.net/drugs/thorazine.htm Asked by Greta Squillace 2 years ago.

Thorazine is no more dangerous than the others. Staying on it for too long can lead to specific complications, which is true with other anti-psychotics. It isn't used as much these days, but it is still a consideration for some people. It's OK to critisize thorazine, but no more so than for other such drugs. Answered by Hwa Castleman 2 years ago.

Wow! Normally, I don't answer questions that want to learn more and more detail. As in your case, because they require a long process, and it is the risk of not solve all of yours problems. I would suggest to proceed analytically with the help of keywords to be included in Yahoo! From what you climb, narrowing the field with new keywords, until you will be fully satisfied. good luck! Answered by Ann Cantella 2 years ago.


Is Thorazine(Chlorpromazine) an older anti-psychotic?
I was prescribed this recently for Bipolar Disorder. Is it an older anti-psychotic?Thanks Asked by Gena Canon 2 years ago.

Thorazine was one of the first anti-psychotics, created in 1950. It is still occasionally used in the treatment of schizophrenia and bipolar disorder, but not as often as it was a few decades ago. It's a low potency anti-psychotic, so there is a lower chance of experiencing unwanted side effects. Answered by Marion Mendizabal 2 years ago.


How long will thorazine take to get in my urine stream?
i want to take a thorazine but i have a drug test at 10:00am and dont know what time yo take it so i can pass the drug test and still take it tonight Asked by Dot Fredericksen 2 years ago.

To my understanding, Thorazine is an anti-psychotic medication. It's not typically screened for on a drug test. However, if you do register with a false positive in another drug category as a result of this medication, all you have to do is show proof of a prescription and you're in the clear. Thorazine is excreted primarily through the urine and has a half-life from 10 to 40 hours. Answered by Arnulfo Ferderer 2 years ago.

You can't wait until after the test to take it - just to be on the safe side? Answered by Porter Walkes 2 years ago.


About Thorazine/Largactil?
I have read alot about this drug, but I would like to hear from somone that has actually used it, or someone who knows someone who has used it.How sedating/tranquilizing is it? What are the main side-effects, and what pills do I need to counteract these side-effects? Asked by Kandi Loukidis 2 years ago.

About counteraction - I'm not sure. You'd have to take it to know if you'd have any counteractions, first. I took Thorazine for about a month for sleep. It never made me tired. It would, however, keep me asleep for 8-12 hrs once I laid down and fell asleep. Not a good drug if you need to be knocked out (in my opinion). I'm sure you've heard it called 'the chemical lobotomy'. I didn't feel like it erased too much of my personality, and I was still heavily addicted to drugs and it never made me seek/want drugs less. I really don't remember much from taking it. I snorted it once, and it burned like a SOB, but it knocked me out right away. Answered by Deon Condry 2 years ago.


Mrs S. has been taking Thorazine for about 1 year?
She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the... Asked by Lorna Mcgirr 2 years ago.

She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the nursing diagnosis for this patient. a) What interventions would be used for this diagnosis? b) How would the nurse evaluate the outcome of the interventions? Answered by Dominic Coray 2 years ago.

thorazine is bound to have more severe side effects.. clozaril is an atypical antipsychotic drug, so it will be LESS likely to cause tardive dyskenesia and akathisia and other similarly devastating side effects (thanks to its anticholinergic properties). However, there is recent evidence that such drugs may increase the likelihood of metabolic disturbances (leading to diabetes) and cardiovascular disease. There are also sexual functioning side effects, but that is common to many psychotropic meds...Note that slow titration of dosing of Clozaril significantly decreases the likelihood of orthostatic hypotension, so the switch is right on the money for this mrs. s....... I would say the switch from thorazine to clozaril is not a bad idea. I have no idea what you mean by "knowledge deficit" and "nursing diagnosis", I'm coming from a clinical psych perspective, but hope this helps! Answered by Deanna Lett 2 years ago.


What is thorazine used for?
Asked by Lynda Detillion 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Toi Gosling 2 years ago.

Thorazine Uses Answered by Tory Merone 2 years ago.

I don't know all of its uses, but I was given Thorazine for migraines. Answered by Darci Hora 2 years ago.

It is a old anti-psychotic. They use to use it a lot in psychiatric hospitals to calm down patients. It is also used for migraines at times. Answered by Tonja Tatsapaugh 2 years ago.

To mess with kids minds! Answered by Natividad Emigholz 2 years ago.

PAIN!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!... Answered by Maria Lambert 2 years ago.

Chlorpromazine was the first antipsychotic drug, used during the 1950s and 1960s. Used as chlorpromazine hydrochloride and sold under the tradenames Largactil® and Thorazine®, it has sedative, hypotensive and antiemetic properties as well as anticholinergic and antidopaminergic effects. It has also anxiolytic (alleviation of anxiety) properties. Today, chlorpromazine is considered a typical antipsychotic. Chlorpromazine acts as an antagonist (blocking agent) on different postsynaptic receptors: on dopaminergic-receptors (subtypes D1, D2, D3 and D4, different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), on alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism—controversial), and on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side effects). Additionally, chlorpromazine is a weak presynaptic inhibitor of dopamine reuptake, which may lead to (mild) antidepressive and antiparkinsonian effects. This action could also account for psychomotor agitation and amplification of psychosis (very rarely noted in clinical use). [edit] Peripheral Antagonist to H1 receptors (antiallergic effects), H2 receptors (reduction of forming of gastric juice), M1/M2-receptors (dry mouth, reduction in forming of gastric juice) and some 5-HT receptors (different anti-allergic/gastrointestinal actions). Because it acts on so many receptors, chlorpromazine is often referred to as "dirty drug", whereas the atypical neuroleptic amisulpride for example acts only on central D2/D3-receptors and is therefore a "clean drug". This distinction is not a positive or negative value judgment on the drug, rather it is a neutral term which merely describes the agent's relative pharmacology. [edit] History The drug had been developed by Laboratoires Rhône-Poulenc in 1950 but they sold the rights in 1952 to Smith-Kline & French (today's GlaxoSmithKline). The drug was being sold as an antiemetic when its other use was noted. Smith-Kline was quick to encourage clinical trials and in 1954 the drug was approved in the US for psychiatric treatment. Over 100 million people were treated but the popularity of the drug fell from the late 1960s as the severe extrapyramidal side effects and tardive dyskinesia became more of a concern. From chlorpromazine a number of other similar neuroleptics were developed (e.g. triflupromazine, trifluoperazine). Previously used as an antihistamine and antiemetic its effects on mental state were first reported by the French doctor Henri Laborit in 1951 or 1952 (different sources) as sedation without narcosis. It became possible to cause 'artificial hibernation' in patients, if used as a cocktail together with pethidine and hydergine. Patients with shock, severe trauma or burns, become, if treated so, sedated, without anxiety and unreponsive/indifferent to painful external stimuli like minor surgical interventions. It was first used for psychiatric patients by Pierre Deniker and Jean Delay in 1953. Drug treatment with chlorpromazine went beyond simple sedation with patients showing improvements in thinking and emotional behaviour. Ironically, the antipsychotic properties of chlorpromazine appear to be unrelated to its sedative properties. During long term therapy some tolerance to the sedation effect develops. Chlorpromazine substituted and eclipsed the old therapies of electro- and insulin shocks and other methods such as psychosurgical means (lobotomy) causing permanent brain injury. Chlorpromazine has given approximately 70% of all schizophrenic patients a complete remission or near so and a normal, gainful human life. Before the era of neuroleptics, starting with chlorpromazine, positive long-term results for psychotic patients were only 20%. [edit] Side effects Side effects of chlorpromazine are typical of early generation neuroleptics. They include extrapyramidal side effects such as tardive dyskinesia and akathisia. A particularly severe side effect is the neuroleptic malignant syndrome which occurs in approximately 0.05% and can be fatal. Also, chlorpromazine may lower seizure threshold. Additional side effects include dry mouth, increased appetite with weight gain, constipation and urinary retention. Glucose tolerance may be impaired. An allergic skin rash and photosensitivity may occur. Other important and severe side effects are a strong reduction in the number of white blood cells, referred to as leukopenia, or, in extreme cases, even agranulocytosis may result, which may lead to death via uncontrollable infections and/or sepsis. Chlorpromazine is the neuroleptic drug with the highest rates (0.5% to 1%) of liver toxicity of the cholestatic type. The sedation effect combined with indifference to physical stimuli, anecdotally known as the "thorazine shuffle," has long been associated with the drug. The image of psychiatric patients staggering mute around a padded cell has earned those particular side effects a place in mainstream pop culture. [edit] Interactions Chlorpromazine intensifies the central depressive action of drugs with such activity (tranquilizers, barbiturates, narcotics, antihistamines, OTC-antiemetics etc.). A dose reduction of chlorpromazine or the other drug may be necessary. Chlorpromazine also intensifies the actions and undesired side effects of antihypertensive medications and anticholinergic drugs. The combination of chlorpromazine with other antipsychotics may result in increased central depression, hypotension and extrapyramidal side effects, but may sometimes enhance the clinical results of therapy. The anti-worm drug (antihelminthic) piperazine may intensify extrapyramidal side effects. In general, all neuroleptics may lead to seizures in combination with tramadol (Ultram). Chlorpromazine may increase the insulin needs of diabetic patients. Drugs like SSRIs, St. John's Wort and barbiturates can inhibit various CYP-isoenzymes such as CYP2D6, needed for metabolization of chlorpromazine and/or its metabolites. Theoretically, this should increase the half-lives of chlorpromazine and possibly its metabolites, dosing changes necessary. The exact clinical significance of this enzyme induction and its therapeutic consequences are unknown at present time and remain to be evaluated. [edit] Uses [edit] Common uses [edit] As an antipsychotic The use of chlorpromazine has been primarily replaced by newer generation of atypical antipsychotics which have an improved side effect profile. Chlorpromazine is classified as a low- to moderate-potency antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of manic depression as well as amphetamine-induced psychoses. Chlorpromazine formerly was the drug of choice to treat LSD (and other psychedelic/hallucinogen) intoxication in a hospital setting, resulting in it gaining an erroneous reputation as the LSD "antidote". Now haloperidol is more commonly used in such situations. [edit] Other uses It has also been used in porphyria, as part of tetanus treatment and for behavioral problems in children. It still is well recommended for short term management of severe anxiety and aggressive episodes. Resistant and severe hiccups, severe nausea/emesis and preanesthetic conditioning have been other indications in the past. It can be used to treat amphetamine overdose. [1] [edit] Off-label and controversial uses Chlorpromazine is occasionally used off-label for treatment of severe migraine. Sometimes it is used in small doses to improve nausea/emesis opioid-treated cancer patients encounter and to intensify and prolong the analgesic action of the opioids given. Interestingly, it remains controversial whether or not chlorpromazine has its own analgesic properties. Analgesic properties may result from a central action on the hypothalamus; the patient may feel the pain much less than before. Other mechanisms may be an interaction with opioid receptors centrally and/or in the spinal cord. Some experts on the contrary say that chlorpromazine, like other phenothiazines, may even have antianalgesic properties. Chlorpromazine has been proposed as useful in newborns for the treatment of opioid withdrawal, if the mother was opioid-dependent. The latter indication remains highly controversial. Chlorpromazine, as well as other neuroleptics, may also be used to alleviate the symptoms of alcohol withdrawal (chlorpromazine may lower the seizure-threshold in alcoholics). It has a unique action in cholera, reducing the loss of water by approximately 30%. In Germany, the brand of chlorpromazine drug Propaphenin® has additional indications for insomnia and itching skin disease. [edit] Veterinary uses Chlorpromazine is primarily used as an antiemetic in dogs and cats. It is also sometimes used as a preanesthetic and muscle relaxant in cattle, swine, sheep, and goats. It is generally contraindicated for use with horses, due to a high incidence of ataxia and altered mentation. [edit] Dosage In any case, use is determined by an attending physician. The following information is intended to serve as a guideline: A wide range is covered from 25 mg oral or intramuscular for mild sedation, every 8 hours, up to 100 mg every 6 hours for severely disturbed patients. Different qualified sources give 800 mg/day to 1,200 mg/day as highest dose. At least there is one small clinical trial in treatment-resistant patients with a daily dose of 1,200 mg chlorpromazine (and 4 mg Benztropine to counteract early extrapyramidal side effects, which were anticipated with this unusual high chlorpromazine dose). Initial doses should be low and be increased gradually. It is recommended that most of the daily dose (e.g. 2/3) is given at bedtime for maximum hypnotic activity and minimal daytime sedation and hypotension. In the USA there are controlled release forms of Thorazine (e.g. 300 mg). After the individual dose is well established, such a CR capsule can be given with the evening meal as a single dose, covering the next 24 hours. The lowest dosage compatible with good therapeutic effect should be given. Dosage in ambulatory patients should be particularly low (minimizing sedation and hypotension). The direct i.v.-injection of undiluted solution is contraindicated (massive fall in blood pressure, cardiovascular collapse), for i.v.-infusion of dilutions the (hospitalized) patient should be lying and the infusion rate should be as slow as possible. Afterwards the patient should rest in the lying position for at least 30 minutes. [edit] Necessary examinations and laboratory checks during treatment All patients treated with chlorpromazine on a long-term-basis should have regularly checked their blood-pressure, pulse rate, laboratory-tests (liver function tests, kidney-values, blood cell counts including differenciated white blood counts, counts of red blood cells and thrombocytes), ECG and EEG. The frequency of all checks should be determined for the individual patient and may be done in shorter intervals during the first 3 months of treatment and less often afterwards. Some side effects seem to appear more frequently during the first months of therapy (sedation, hypotension, liver damage) while others do not (e.g. tardive dyskinesia). [edit] Discontinuation of treatment Also, in regular intervals the treating physician should evaluate whether continued treatment is needed. If not, the drug should never be stopped suddenly, due to very unpleasant 'withdrawal-symptoms', such as agitation, sleeplessness, states of anxiety, etc. However, these symptoms definitely do not indicate psychological or physical dependence. The dose should rather be slowly tapered down at a rate of approximately 20–25% per week or even slower to avoid the aforementioned bothersome symptoms. Chlorpromazine is derived from phenothiazine, and has an aliphatic side chain, typical for low to middle potency neuroleptics. The oral bioavailability is estimated to be 30–50% due to extensive first pass metabolization in the liver. Its elimination-halflife is 16–30 hours. It has many active metabolites (approx. 75 different ones) with greatly varying halflives and own pharmacological profiles. The CYP-450 isoenzymes 1A2 and 2D6 are needed for metabolization of chlorpromazine and the subtype 2D6 is inhibited by chlorpromazine (NB: possible interactions with other drugs). Answered by Monte Wojtas 2 years ago.


What are some reasons why a person might be prescribed 200 mg of thorazine?
...from a medical prospective. Asked by Leigh Tews 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Bruno Kahao 2 years ago.

The warding off man or woman will have angry through a comment the have shyed away from man or woman made. The warding off man or woman will have a few prejudice towards the have shyed away from man or woman. The have shyed away from man or woman might remind the warding off man or woman of an ex-boyfriend or ex-female friend or different man or woman who the warding off man or woman desires to omit. Maybe anybody instructed the warding off man or woman that the have shyed away from man or woman does not like him/her. But the object is, why do you care? Answered by Phillis Ater 2 years ago.

It's an anti-psychotic, for bipolar disorder or schizophrenia. Answered by Miguel Wekenborg 2 years ago.


What is Thorazine, Lorazepam and Compazine? What are they used for?
Asked by Devona Retherford 2 years ago.

Chlorpromazine is classified as a low-potency typical antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of bipolar disorder, as well as amphetamine-induced psychoses. Low-potency antipsychotics have more anticholinergic side effects, such as dry mouth, sedation, and constipation, and lower rates of extrapyramidal side effects, while high-potency antipsychotics (such as haloperidol) have the reverse profile. Chlorpromazine has also been used in porphyria and as part of tetanus treatment. It still is recommended for short-term management of severe anxiety and psychotic aggression. Resistant and severe hiccups, severe nausea/emesis, and preanesthetic conditioning are other uses. Symptoms of delirium in medically-hospitalized AIDS patients have been effectively treated with low doses of chlorpromazine Answered by Ollie Brad 2 years ago.

They are antipsycotic drugs used to treat manic depression, schizophrenia Answered by Mai Ast 2 years ago.


Is 25 mg of Thorazine safe to take for anxiety?
Asked by Tawny Dirkson 2 years ago.

Thorazine, at 25 mg, is used for chronic hiccups, nausea and vomitting, sedation before surgery, and sometimes anxiety. However, it is anti-psychotic, a tranquilizer, and very old school, so if it was not prescribed to you, don't tske it. This may just be a question of general curiosity, but if you need meds for anxiety, there are more suitable ones than thorazine. See the doc. to get the right one for you! Answered by Yajaira Haskell 2 years ago.

Thorazine is not an anti-anxiety drug. It is an antipsychotic drug. Please do not take ANY prescription medication unless under the direction of your personal physician. Answered by Tera Bezanson 2 years ago.

I think I would speak to a Pharmacist before listening to someone on Yahoo answers. Answered by Hans Pavlas 2 years ago.

The potential for causing chronic movement disorders makes it far from ideal. Answered by Adrien Schnake 2 years ago.

It has more potential side effects than newer drugs. For example, seizures, heat exhaustion, drowsiness. Answered by Christene Maeda 2 years ago.


Is it true that Thorazine is as dangerous and the Psychiatric critics say it is?
From Psychiatric critics they criticize Thorazine a lot and say it messes people up like Lobotomy. Here is an example website criticizing Thorazine: http://www.sntp.net/drugs/thorazine.htm Asked by Precious Caristo 2 years ago.

Thorazine is no more dangerous than the others. Staying on it for too long can lead to specific complications, which is true with other anti-psychotics. It isn't used as much these days, but it is still a consideration for some people. It's OK to critisize thorazine, but no more so than for other such drugs. Answered by Yesenia Schechter 2 years ago.

Wow! Normally, I don't answer questions that want to learn more and more detail. As in your case, because they require a long process, and it is the risk of not solve all of yours problems. I would suggest to proceed analytically with the help of keywords to be included in Yahoo! From what you climb, narrowing the field with new keywords, until you will be fully satisfied. good luck! Answered by Melodie Lieurance 2 years ago.


Is Thorazine(Chlorpromazine) an older anti-psychotic?
I was prescribed this recently for Bipolar Disorder. Is it an older anti-psychotic?Thanks Asked by Whitney Haehn 2 years ago.

Thorazine was one of the first anti-psychotics, created in 1950. It is still occasionally used in the treatment of schizophrenia and bipolar disorder, but not as often as it was a few decades ago. It's a low potency anti-psychotic, so there is a lower chance of experiencing unwanted side effects. Answered by Onie Hatherly 2 years ago.


How long will thorazine take to get in my urine stream?
i want to take a thorazine but i have a drug test at 10:00am and dont know what time yo take it so i can pass the drug test and still take it tonight Asked by Gordon Novikoff 2 years ago.

To my understanding, Thorazine is an anti-psychotic medication. It's not typically screened for on a drug test. However, if you do register with a false positive in another drug category as a result of this medication, all you have to do is show proof of a prescription and you're in the clear. Thorazine is excreted primarily through the urine and has a half-life from 10 to 40 hours. Answered by Neely Fabeck 2 years ago.

You can't wait until after the test to take it - just to be on the safe side? Answered by Jannie Nickols 2 years ago.


About Thorazine/Largactil?
I have read alot about this drug, but I would like to hear from somone that has actually used it, or someone who knows someone who has used it.How sedating/tranquilizing is it? What are the main side-effects, and what pills do I need to counteract these side-effects? Asked by Caroll Capas 2 years ago.

About counteraction - I'm not sure. You'd have to take it to know if you'd have any counteractions, first. I took Thorazine for about a month for sleep. It never made me tired. It would, however, keep me asleep for 8-12 hrs once I laid down and fell asleep. Not a good drug if you need to be knocked out (in my opinion). I'm sure you've heard it called 'the chemical lobotomy'. I didn't feel like it erased too much of my personality, and I was still heavily addicted to drugs and it never made me seek/want drugs less. I really don't remember much from taking it. I snorted it once, and it burned like a SOB, but it knocked me out right away. Answered by Raylene Hasley 2 years ago.


Mrs S. has been taking Thorazine for about 1 year?
She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the... Asked by Clare Manske 2 years ago.

She has been having problems with orthostatic hypotension and akathisia, and has needed to take Cogentin to avoid dystonic reactions. The physician has decided to change her to Clozaril. The patient asks the nurse about the advantages and disadvantages of the new drug. The nurse has chosen Knowledge Deficit as the nursing diagnosis for this patient. a) What interventions would be used for this diagnosis? b) How would the nurse evaluate the outcome of the interventions? Answered by Kymberly Suominen 2 years ago.

thorazine is bound to have more severe side effects.. clozaril is an atypical antipsychotic drug, so it will be LESS likely to cause tardive dyskenesia and akathisia and other similarly devastating side effects (thanks to its anticholinergic properties). However, there is recent evidence that such drugs may increase the likelihood of metabolic disturbances (leading to diabetes) and cardiovascular disease. There are also sexual functioning side effects, but that is common to many psychotropic meds...Note that slow titration of dosing of Clozaril significantly decreases the likelihood of orthostatic hypotension, so the switch is right on the money for this mrs. s....... I would say the switch from thorazine to clozaril is not a bad idea. I have no idea what you mean by "knowledge deficit" and "nursing diagnosis", I'm coming from a clinical psych perspective, but hope this helps! Answered by Mauro Sprowls 2 years ago.


What is thorazine used for?
Asked by Loreen Clattenburg 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Phillip Wytch 2 years ago.

Thorazine Uses Answered by Alexandria Gora 2 years ago.

I don't know all of its uses, but I was given Thorazine for migraines. Answered by Barb Bina 2 years ago.

It is a old anti-psychotic. They use to use it a lot in psychiatric hospitals to calm down patients. It is also used for migraines at times. Answered by Mildred Desnoyers 2 years ago.

To mess with kids minds! Answered by Kristofer Recore 2 years ago.

PAIN!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!... Answered by Chanelle Laurel 2 years ago.

Chlorpromazine was the first antipsychotic drug, used during the 1950s and 1960s. Used as chlorpromazine hydrochloride and sold under the tradenames Largactil® and Thorazine®, it has sedative, hypotensive and antiemetic properties as well as anticholinergic and antidopaminergic effects. It has also anxiolytic (alleviation of anxiety) properties. Today, chlorpromazine is considered a typical antipsychotic. Chlorpromazine acts as an antagonist (blocking agent) on different postsynaptic receptors: on dopaminergic-receptors (subtypes D1, D2, D3 and D4, different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), on alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism—controversial), and on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side effects). Additionally, chlorpromazine is a weak presynaptic inhibitor of dopamine reuptake, which may lead to (mild) antidepressive and antiparkinsonian effects. This action could also account for psychomotor agitation and amplification of psychosis (very rarely noted in clinical use). [edit] Peripheral Antagonist to H1 receptors (antiallergic effects), H2 receptors (reduction of forming of gastric juice), M1/M2-receptors (dry mouth, reduction in forming of gastric juice) and some 5-HT receptors (different anti-allergic/gastrointestinal actions). Because it acts on so many receptors, chlorpromazine is often referred to as "dirty drug", whereas the atypical neuroleptic amisulpride for example acts only on central D2/D3-receptors and is therefore a "clean drug". This distinction is not a positive or negative value judgment on the drug, rather it is a neutral term which merely describes the agent's relative pharmacology. [edit] History The drug had been developed by Laboratoires Rhône-Poulenc in 1950 but they sold the rights in 1952 to Smith-Kline & French (today's GlaxoSmithKline). The drug was being sold as an antiemetic when its other use was noted. Smith-Kline was quick to encourage clinical trials and in 1954 the drug was approved in the US for psychiatric treatment. Over 100 million people were treated but the popularity of the drug fell from the late 1960s as the severe extrapyramidal side effects and tardive dyskinesia became more of a concern. From chlorpromazine a number of other similar neuroleptics were developed (e.g. triflupromazine, trifluoperazine). Previously used as an antihistamine and antiemetic its effects on mental state were first reported by the French doctor Henri Laborit in 1951 or 1952 (different sources) as sedation without narcosis. It became possible to cause 'artificial hibernation' in patients, if used as a cocktail together with pethidine and hydergine. Patients with shock, severe trauma or burns, become, if treated so, sedated, without anxiety and unreponsive/indifferent to painful external stimuli like minor surgical interventions. It was first used for psychiatric patients by Pierre Deniker and Jean Delay in 1953. Drug treatment with chlorpromazine went beyond simple sedation with patients showing improvements in thinking and emotional behaviour. Ironically, the antipsychotic properties of chlorpromazine appear to be unrelated to its sedative properties. During long term therapy some tolerance to the sedation effect develops. Chlorpromazine substituted and eclipsed the old therapies of electro- and insulin shocks and other methods such as psychosurgical means (lobotomy) causing permanent brain injury. Chlorpromazine has given approximately 70% of all schizophrenic patients a complete remission or near so and a normal, gainful human life. Before the era of neuroleptics, starting with chlorpromazine, positive long-term results for psychotic patients were only 20%. [edit] Side effects Side effects of chlorpromazine are typical of early generation neuroleptics. They include extrapyramidal side effects such as tardive dyskinesia and akathisia. A particularly severe side effect is the neuroleptic malignant syndrome which occurs in approximately 0.05% and can be fatal. Also, chlorpromazine may lower seizure threshold. Additional side effects include dry mouth, increased appetite with weight gain, constipation and urinary retention. Glucose tolerance may be impaired. An allergic skin rash and photosensitivity may occur. Other important and severe side effects are a strong reduction in the number of white blood cells, referred to as leukopenia, or, in extreme cases, even agranulocytosis may result, which may lead to death via uncontrollable infections and/or sepsis. Chlorpromazine is the neuroleptic drug with the highest rates (0.5% to 1%) of liver toxicity of the cholestatic type. The sedation effect combined with indifference to physical stimuli, anecdotally known as the "thorazine shuffle," has long been associated with the drug. The image of psychiatric patients staggering mute around a padded cell has earned those particular side effects a place in mainstream pop culture. [edit] Interactions Chlorpromazine intensifies the central depressive action of drugs with such activity (tranquilizers, barbiturates, narcotics, antihistamines, OTC-antiemetics etc.). A dose reduction of chlorpromazine or the other drug may be necessary. Chlorpromazine also intensifies the actions and undesired side effects of antihypertensive medications and anticholinergic drugs. The combination of chlorpromazine with other antipsychotics may result in increased central depression, hypotension and extrapyramidal side effects, but may sometimes enhance the clinical results of therapy. The anti-worm drug (antihelminthic) piperazine may intensify extrapyramidal side effects. In general, all neuroleptics may lead to seizures in combination with tramadol (Ultram). Chlorpromazine may increase the insulin needs of diabetic patients. Drugs like SSRIs, St. John's Wort and barbiturates can inhibit various CYP-isoenzymes such as CYP2D6, needed for metabolization of chlorpromazine and/or its metabolites. Theoretically, this should increase the half-lives of chlorpromazine and possibly its metabolites, dosing changes necessary. The exact clinical significance of this enzyme induction and its therapeutic consequences are unknown at present time and remain to be evaluated. [edit] Uses [edit] Common uses [edit] As an antipsychotic The use of chlorpromazine has been primarily replaced by newer generation of atypical antipsychotics which have an improved side effect profile. Chlorpromazine is classified as a low- to moderate-potency antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of manic depression as well as amphetamine-induced psychoses. Chlorpromazine formerly was the drug of choice to treat LSD (and other psychedelic/hallucinogen) intoxication in a hospital setting, resulting in it gaining an erroneous reputation as the LSD "antidote". Now haloperidol is more commonly used in such situations. [edit] Other uses It has also been used in porphyria, as part of tetanus treatment and for behavioral problems in children. It still is well recommended for short term management of severe anxiety and aggressive episodes. Resistant and severe hiccups, severe nausea/emesis and preanesthetic conditioning have been other indications in the past. It can be used to treat amphetamine overdose. [1] [edit] Off-label and controversial uses Chlorpromazine is occasionally used off-label for treatment of severe migraine. Sometimes it is used in small doses to improve nausea/emesis opioid-treated cancer patients encounter and to intensify and prolong the analgesic action of the opioids given. Interestingly, it remains controversial whether or not chlorpromazine has its own analgesic properties. Analgesic properties may result from a central action on the hypothalamus; the patient may feel the pain much less than before. Other mechanisms may be an interaction with opioid receptors centrally and/or in the spinal cord. Some experts on the contrary say that chlorpromazine, like other phenothiazines, may even have antianalgesic properties. Chlorpromazine has been proposed as useful in newborns for the treatment of opioid withdrawal, if the mother was opioid-dependent. The latter indication remains highly controversial. Chlorpromazine, as well as other neuroleptics, may also be used to alleviate the symptoms of alcohol withdrawal (chlorpromazine may lower the seizure-threshold in alcoholics). It has a unique action in cholera, reducing the loss of water by approximately 30%. In Germany, the brand of chlorpromazine drug Propaphenin® has additional indications for insomnia and itching skin disease. [edit] Veterinary uses Chlorpromazine is primarily used as an antiemetic in dogs and cats. It is also sometimes used as a preanesthetic and muscle relaxant in cattle, swine, sheep, and goats. It is generally contraindicated for use with horses, due to a high incidence of ataxia and altered mentation. [edit] Dosage In any case, use is determined by an attending physician. The following information is intended to serve as a guideline: A wide range is covered from 25 mg oral or intramuscular for mild sedation, every 8 hours, up to 100 mg every 6 hours for severely disturbed patients. Different qualified sources give 800 mg/day to 1,200 mg/day as highest dose. At least there is one small clinical trial in treatment-resistant patients with a daily dose of 1,200 mg chlorpromazine (and 4 mg Benztropine to counteract early extrapyramidal side effects, which were anticipated with this unusual high chlorpromazine dose). Initial doses should be low and be increased gradually. It is recommended that most of the daily dose (e.g. 2/3) is given at bedtime for maximum hypnotic activity and minimal daytime sedation and hypotension. In the USA there are controlled release forms of Thorazine (e.g. 300 mg). After the individual dose is well established, such a CR capsule can be given with the evening meal as a single dose, covering the next 24 hours. The lowest dosage compatible with good therapeutic effect should be given. Dosage in ambulatory patients should be particularly low (minimizing sedation and hypotension). The direct i.v.-injection of undiluted solution is contraindicated (massive fall in blood pressure, cardiovascular collapse), for i.v.-infusion of dilutions the (hospitalized) patient should be lying and the infusion rate should be as slow as possible. Afterwards the patient should rest in the lying position for at least 30 minutes. [edit] Necessary examinations and laboratory checks during treatment All patients treated with chlorpromazine on a long-term-basis should have regularly checked their blood-pressure, pulse rate, laboratory-tests (liver function tests, kidney-values, blood cell counts including differenciated white blood counts, counts of red blood cells and thrombocytes), ECG and EEG. The frequency of all checks should be determined for the individual patient and may be done in shorter intervals during the first 3 months of treatment and less often afterwards. Some side effects seem to appear more frequently during the first months of therapy (sedation, hypotension, liver damage) while others do not (e.g. tardive dyskinesia). [edit] Discontinuation of treatment Also, in regular intervals the treating physician should evaluate whether continued treatment is needed. If not, the drug should never be stopped suddenly, due to very unpleasant 'withdrawal-symptoms', such as agitation, sleeplessness, states of anxiety, etc. However, these symptoms definitely do not indicate psychological or physical dependence. The dose should rather be slowly tapered down at a rate of approximately 20–25% per week or even slower to avoid the aforementioned bothersome symptoms. Chlorpromazine is derived from phenothiazine, and has an aliphatic side chain, typical for low to middle potency neuroleptics. The oral bioavailability is estimated to be 30–50% due to extensive first pass metabolization in the liver. Its elimination-halflife is 16–30 hours. It has many active metabolites (approx. 75 different ones) with greatly varying halflives and own pharmacological profiles. The CYP-450 isoenzymes 1A2 and 2D6 are needed for metabolization of chlorpromazine and the subtype 2D6 is inhibited by chlorpromazine (NB: possible interactions with other drugs). Answered by Erlinda Neuhart 2 years ago.


What are some reasons why a person might be prescribed 200 mg of thorazine?
...from a medical prospective. Asked by Lanelle Saeteun 2 years ago.

Thorazine is used for the treatment of schizophrenia (severe disruptions in thought and perception). It is also prescribed for the short-term treatment of severe behavioral disorders in children, including explosive hyperactivity and combativeness; and for the hyperenergetic phase of manic-depressive illness (severely exaggerated moods). Thorazine is also used to control nausea and vomiting, and to relieve restlessness and apprehension before surgery. It is used as an aid in the treatment of tetanus, and is prescribed for uncontrollable hiccups and acute intermittent porphyria (attacks of severe abdominal pain sometimes accompanied by psychiatric disturbances, cramps in the arms and legs, and muscle weakness). Answered by Dorothea Silvester 2 years ago.

The warding off man or woman will have angry through a comment the have shyed away from man or woman made. The warding off man or woman will have a few prejudice towards the have shyed away from man or woman. The have shyed away from man or woman might remind the warding off man or woman of an ex-boyfriend or ex-female friend or different man or woman who the warding off man or woman desires to omit. Maybe anybody instructed the warding off man or woman that the have shyed away from man or woman does not like him/her. But the object is, why do you care? Answered by Elouise Zinkievich 2 years ago.

It's an anti-psychotic, for bipolar disorder or schizophrenia. Answered by Loren Robuck 2 years ago.


What is Thorazine, Lorazepam and Compazine? What are they used for?
Asked by Meda Be 2 years ago.

Chlorpromazine is classified as a low-potency typical antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of bipolar disorder, as well as amphetamine-induced psychoses. Low-potency antipsychotics have more anticholinergic side effects, such as dry mouth, sedation, and constipation, and lower rates of extrapyramidal side effects, while high-potency antipsychotics (such as haloperidol) have the reverse profile. Chlorpromazine has also been used in porphyria and as part of tetanus treatment. It still is recommended for short-term management of severe anxiety and psychotic aggression. Resistant and severe hiccups, severe nausea/emesis, and preanesthetic conditioning are other uses. Symptoms of delirium in medically-hospitalized AIDS patients have been effectively treated with low doses of chlorpromazine Answered by Carlotta Staelens 2 years ago.

They are antipsycotic drugs used to treat manic depression, schizophrenia Answered by Laronda Loo 2 years ago.


Is 25 mg of Thorazine safe to take for anxiety?
Asked by Williams Demorrett 2 years ago.

Thorazine, at 25 mg, is used for chronic hiccups, nausea and vomitting, sedation before surgery, and sometimes anxiety. However, it is anti-psychotic, a tranquilizer, and very old school, so if it was not prescribed to you, don't tske it. This may just be a question of general curiosity, but if you need meds for anxiety, there are more suitable ones than thorazine. See the doc. to get the right one for you! Answered by Keenan Dawahoya 2 years ago.

Thorazine is not an anti-anxiety drug. It is an antipsychotic drug. Please do not take ANY prescription medication unless under the direction of your personal physician. Answered by Neda Laramie 2 years ago.

I think I would speak to a Pharmacist before listening to someone on Yahoo answers. Answered by Arie Bolado 2 years ago.

The potential for causing chronic movement disorders makes it far from ideal. Answered by Ellamae Goudy 2 years ago.

It has more potential side effects than newer drugs. For example, seizures, heat exhaustion, drowsiness. Answered by Gertrudis Murrell 2 years ago.


Is it true that Thorazine is as dangerous and the Psychiatric critics say it is?
From Psychiatric critics they criticize Thorazine a lot and say it messes people up like Lobotomy. Here is an example website criticizing Thorazine: http://www.sntp.net/drugs/thorazine.htm Asked by Lilliana Hueftle 2 years ago.

Thorazine is no more dangerous than the others. Staying on it for too long can lead to specific complications, which is true with other anti-psychotics. It isn't used as much these days, but it is still a consideration for some people. It's OK to critisize thorazine, but no more so than for other such drugs. Answered by Lorita Riso 2 years ago.

Wow! Normally, I don't answer questions that want to learn more and more detail. As in your case, because they require a long process, and it is the risk of not solve all of yours problems. I would suggest to proceed analytically with the help of keywords to be included in Yahoo! From what you climb, narrowing the field with new keywords, until you will be fully satisfied. good luck! Answered by Laure Swire 2 years ago.


Is Thorazine(Chlorpromazine) an older anti-psychotic?
I was prescribed this recently for Bipolar Disorder. Is it an older anti-psychotic?Thanks Asked by Rudolph Mcclod 2 years ago.

Thorazine was one of the first anti-psychotics, created in 1950. It is still occasionally used in the treatment of schizophrenia and bipolar disorder, but not as often as it was a few decades ago. It's a low potency anti-psychotic, so there is a lower chance of experiencing unwanted side effects. Answered by Sara Bishard 2 years ago.


How long will thorazine take to get in my urine stream?
i want to take a thorazine but i have a drug test at 10:00am and dont know what time yo take it so i can pass the drug test and still take it tonight Asked by Opal Muray 2 years ago.

To my understanding, Thorazine is an anti-psychotic medication. It's not typically screened for on a drug test. However, if you do register with a false positive in another drug category as a result of this medication, all you have to do is show proof of a prescription and you're in the clear. Thorazine is excreted primarily through the urine and has a half-life from 10 to 40 hours. Answered by Euna Finizio 2 years ago.

You can't wait until after the test to take it - just to be on the safe side? Answered by Jere Grauer 2 years ago.


About Thorazine/Largactil?
I have read alot about this drug, but I would like to hear from somone that has actually used it, or someone who knows someone who has used it.How sedating/tranquilizing is it? What are the main side-effects, and what pills do I need to counteract these side-effects? Asked by Yolanda Ozier 2 years ago.

About counteraction - I'm not sure. You'd have to take it to know if you'd have any counteractions, first. I took Thorazine for about a month for sleep. It never made me tired. It would, however, keep me asleep for 8-12 hrs once I laid down and fell asleep. Not a good drug if you need to be knocked out (in my opinion). I'm sure you've heard it called 'the chemical lobotomy'. I didn't feel like it erased too much of my personality, and I was still heavily addicted to drugs and it never made me seek/want drugs less. I really don't remember much from taking it. I snorted it once, and it burned like a SOB, but it knocked me out right away. Answered by Katina Bonsignore 2 years ago.


Related

Browse by letter
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

© Medications.li 2015-2017 - All rights reserved