Application Information

This drug has been submitted to the FDA under the reference 020262/001.

Names and composition

"TAXOL" is the commercial name of a drug composed of PACLITAXEL.

Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
020262/001 TAXOL PACLITAXEL INJECTABLE/INJECTION 6MG per ML

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
020262/001 TAXOL PACLITAXEL INJECTABLE/INJECTION 6MG per ML
021660/001 ABRAXANE PACLITAXEL FOR SUSPENSION/IV (INFUSION) 100MG per VIAL
075184/001 PACLITAXEL PACLITAXEL INJECTABLE/INJECTION 6MG per ML
075190/001 PACLITAXEL PACLITAXEL INJECTABLE/INJECTION 6MG per ML
075278/001 PACLITAXEL PACLITAXEL INJECTABLE/INJECTION 6MG per ML
075297/001 PACLITAXEL PACLITAXEL INJECTABLE/INJECTION 6MG per ML
075436/001 PACLITAXEL PACLITAXEL INJECTABLE/INJECTION 6MG per ML
076131/001 PACLITAXEL PACLITAXEL INJECTABLE/INJECTION 6MG per ML
076233/001 PACLITAXEL PACLITAXEL INJECTABLE/INJECTION 6MG per ML
077413/001 PACLITAXEL PACLITAXEL INJECTABLE/INJECTION 6MG per ML
077574/001 PACLITAXEL PACLITAXEL INJECTABLE/INJECTION 6MG per ML
078167/001 PACLITAXEL PACLITAXEL INJECTABLE/INJECTION 6MG per ML
090130/001 PACLITAXEL PACLITAXEL INJECTABLE/INJECTION 6MG per ML
091540/001 PACLITAXEL PACLITAXEL INJECTABLE/INJECTION 6MG per ML
207326/001 PACITAXEL PACLITAXEL INJECTABLE/INJECTION 6MG per ML

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Answered questions

Just been told that i have to have taxol weekly for 12 weeks, then the rest of chemo once a week every 3 weeks?
has anyone else done this, what are the side effects, was told hair would thin, not fallout completely yet - that will follow with the 2nd half of my treatment. hope this breast cancer goes away forever Asked by Livia Nevel 1 year ago.

I had Taxol and Herceptin for 12 weeks after Dose Dense AC. Taxol was very easy compared to AC (for me and most women). No nausea. Appetite was great. No mouth sores. White counts were fine, but did develop some anemia. And I did lose the "rest" of my hair (lashes, brows, and body hair), so I'm not sure the "thinning" part they told you was accurate. However, Taxol has a nasty cumulative effect. I was fine, literally like I wasn't even on chemo, for about 6 weeks. Then I started noticing stuff. My legs felt tired ... then the started to get sore (muscles), and then the soreness got worse so I could barely stand for them to be touched. They (legs/ankles/feet) swelled every day, but would return to normal at night ... except for the last few weeks, when they simply refused to release the fluids. I could barely manage 20 minutes on the treadmill each day. Then I could barely pull it off every other day. I would get winded just going up a flight of stairs. Fortunately, the body does recover from these things. A few weeks after I finished things were much better. Now, 6 months after the end of Taxol, all the issues I was having are pretty much gone ... though my legs still swell a bit. I'm thinking that's the Herceptin I'm still getting. The nurses warned me the Taxol would have a cumulative effect, but when I kept feeling good week after week, I though maybe I would be different. Not true. Toward the end, it will be a noticeable effect. Many women have neuropathy issues like tingling and numbness in the extremities. I never had that happen. Some have other pain like joint and bone pain. I didn't have that either, just the leg muscles. Answered by Casie Grunewald 1 year ago.

Sure, in the event you desire to sniff and might be get a illness down beneath. There aren't any regulations as to what you will have to and shouldnt do in the case of hygiene..simply strategies. If that is an sincere query, I could difference ALL your garments as soon as an afternoon and bathe a minimum of everyother day... Answered by Rickey Laprise 1 year ago.


Does taxol make you dizzy?
My relative has one more treatment with it and claims it has made her very light headed. Asked by Odell Jerrel 1 year ago.

i get dizzy when i see lots of blood i work in ahospital Answered by Crystle Tatro 1 year ago.


Question about Cancer drug Taxol?
how does Taxol affect cancer cells? and would it also affect non-cancerous cells? if,so which ones? Asked by Doyle Shepley 1 year ago.

My wife was on 12 weeks of Taxol, and it prevents cancerous cells from dividing properly and attacks normal cells also but they are able to repair themselves. The effects of Taxol can vary according to individual patients. Some experience nerve damage and nerves take a long time to repair, so one can experience numbness in fingers and toes. It can also cause watery eyes and dry mouth. Again once you are finished taking Taxol, your body slowly begins repairing the damage. It has been seven months since my wife's last Taxol treatments and she just this week was able to shuffle a deck of cards without her hands being in pain. Answered by Vanetta Plumb 1 year ago.

Taxol (or Paclitaxel) works on all fast growing cells - cancerous or non-cancerous. Cancer is a result of uncontrolled cell division. Chemo (including taxol) inhibits these cells from dividing and puts a tab on uncontrolled growths in the body. The other fast growing cells are hair follicles and lining of the intestine. A person on Taxol is bound to lose hair and may have upset bowels. Blood cells also divide fast hence you may see an abrupt drop in your blood count which makes the immune system weak. Answered by Nelson Dedominicis 1 year ago.

Taxol is a mitotic inhibitor it works be interfering with the microtubules that normal cell division requires. It effects normal cells too but because cancer cells divide more rapidly it affects them more. It may induce programmed cell death in cancer cells also Answered by Lashonda Dubon 1 year ago.

To the best of my knowledge it affect all quickly dividing cells, I think it disrupts cell replication at a particular stage (sorry don't remember the stage). It can affect the digestive mucosa cells and the peripheral nerves in your hands and feet. Sometimes these effects are reversible and sometimes not. Answered by Glenn Svatos 1 year ago.

No, 90% of chemotherapy drugs are non-specific -- they simply kill every cell they come in contact with. Hence all the nasty side effects. Answered by Meridith Patolot 1 year ago.


What is the drug taxol used for? Is it effective?
I have a friend with breast cancer and she will be using this shortly. Asked by Kirby Bellanca 1 year ago.

All of the answers above are correct. So I will give you my personal experience with taxol. First of all, taxol is extremely toxic and is very effective in treating cancer. However, like all cancers, the effectiveness of the chemotherapeutic agent also depends on the type of cancer, the stage of the cancer, and the body's response to the drug. I had 6 rounds to taxol administered every 3 weeks. Due to the toxicity of taxol, I believe 6 taxol treatments is the maximum and can be administered no closer than 3 weeks apart. Longer is ok but not less than 3 weeks. Expect to go to the lab several days before having chemo to see how well the liver is metabolizing the drug. Also expect to go to the doctor or lab to get additional blood work done (7-10 days after chemo) to see what the blood counts are. If the counts are low, then you can get the shots that will boost your counts. In addition, if counts are low, ask the doctor for a referral to a nutritionist that works with cancer patients. Taxol is administered through an IV drip (mine was over 3 hours just for the taxol alone). Stay hydrated and drink plenty of fluids to plump up the veins. It will make it easier to adm. chemo. Since taxol is very toxic, it may "burn/hardened" the vein making it difficult to reuse the vein the next time. Answered by Maryam Midthun 1 year ago.

Taxol is a cancer (antineoplastic) medication. Taxol interferes with the growth of cancer cells and slows their growth and spread in the body. It is used in the treatment of breast, ovary and lung cancers, and AIDS-related Kaposi's sarcoma. It's the newest most effective treatment Answered by Nicky Coventry 1 year ago.

Taxol is a cancer (antineoplastic) medication. Taxol interferes with the growth of cancer cells and slows their growth and spread in the body. It is used in the treatment of breast, ovary and lung cancers, and AIDS-related Kaposi's sarcoma Answered by Mina Hazelett 1 year ago.

Taxol is similar in how it works on the body, similar to Taxotere. Both are derivatives of the Yew Tree and can be very toxic on the human body. (as are many other chemotherapy drugs). It is one of the more commonly prescribed therapies in breast cancer treatment. Answered by Allyson Brobeck 1 year ago.


Brief me bout whether taxol is produced by plants or from fungi present as a endophyte in pacific yew tree?
Asked by Dedra Ganiban 1 year ago.

Taxol is found in the bark of the Pacific Yew (Taxus brevifolia). But there is an endophyte growing there. Taxomyces andreanae, a fungal endophyte, was isolated from the phloem (inner bark) of the Pacific yew, Taxus brevifolia. The fungus is hyphomyceteous and, when grown in a semi-synthetic liquid medium, produced taxol and related compounds. Answered by Albertina Sallee 1 year ago.


How long does leg pain from taxol last?
my mom and sister started taxol treaments last friday. sunday they woke up with horrible leg pains. i am just wondering if any one has gone through this and how long before the pain started to go away. and any recomendations as how to deal with the pain. thanks for any help anyone can give me. Asked by Jamika Meua 1 year ago.

Well I looked up Taxol to be sure I got the information right. It says "if you have any side effects, like swelling, pain, muscle or joint pain, call your doctor right away and tell him because you may be having an allergic reaction" So, I say, let your Dr know. As far as dealing with the pain, if your Dr takes you off it and gives you something else, the pain will go away. That's why it's important that you let him know. My Oncologist wanted to put me on Taxol and I refused. That's just my personal choice. I hate all those drugs. Good luck and call OK. Answered by Tracey Palmore 1 year ago.

Everyone reacts a bit differently, but for me the worst was from about the 3rd to 6th day after treatments. To ease the pain warm baths help a bit, Advil or something stronger, and if they can manage it mild exercise like walking. www.breastcancer.org is an excellent site for information Answered by Mercedez Gouldie 1 year ago.


What are two plant generas that are related to taxol that can be used for taxol research?
Asked by Calvin Wims 1 year ago.

The original source of Taxol was the pacific yew (Taxus brevifolia) from which the drug got it's name using Taxus, the scientific name for the plant it came from + -ol, a suffix used for compounds containing alcohol. Later, because of environmental concerns and a relative scaricty of Pacific yews, English yews (Taxus baccata) were used to isolate a similar compound which could be used for to synthesize taxol in the lab. But both of these plants would be from the same genera (Taxus). I'm not aware of any other genera that was used as the source of Taxol, although the action of Taxol was thought to be similar as that of vinca alkaloids. Madagascar periwinkle (Catharanthus roseus) particularly was studied for anti-cancer properties. But how this plant affects tumors is different than the action of Taxol. Answered by Kit Ebel 1 year ago.


Hello.please answer me how do taxol against the cancer?
he or she please answer these question rapidly Asked by Kary Pentek 1 year ago.

English isn't your first language, is it? "How do taxol against the cancer". Could this mean "How does Taxol work to fight cancer"?? I'll go with this. Taxol (paclitaxel) is used as a first-line and subsequent therapy for advanced ovarian cancer; for breast cancer after failure of a combination of chemo for metastatic cancer or relapse within 6 months of adjuvant chemo (Adjuvant means in addition to something else) with anthracycline as the other therapy; as an adjuvant treatment of node-positive breast cancer and is given sequentially to standard doxorunicin-containing chemo; as a first treatment of advanced non-small-cell lung cancer for patients who aren't candidates for curative surgery or radiation. The medication prevents depolymerization of cellular microtubules, inhibiting normal reorganization of the microtubule network needed for mitosis and other vital cellular functions. Which means Taxol prevents cancer cells from dividing (mitosis) and thus reproducing and multiplying. If they can't reproduce, they eventually die off. It also prevents "other vital cellular functions" which may mean cellular metabolism and utilization of glucose. Starve and die. Answered by Graham Ollison 1 year ago.


Breastcancer.Chemotherapy.Expe... with TAXOL ?
After the operation I got 4 times AC treatment, this week for the first time Taxol. I have heavy side effects ! Who got Taxol tratment too and has any tip for me what helps with the pain and loss of feeling in the fingertips ? Will it become less after a few days ?How many mgr of this medication did they... Asked by Joanie Witt 1 year ago.

After the operation I got 4 times AC treatment, this week for the first time Taxol. I have heavy side effects ! Who got Taxol tratment too and has any tip for me what helps with the pain and loss of feeling in the fingertips ? Will it become less after a few days ? How many mgr of this medication did they inject ? Thank you so much ! Answered by Annemarie Danowski 1 year ago.

Hi Shanti, I had the whole gammit ~ surgery (mastectomy), chemo, radiation, & now the hormonal therapy (5 yrs worth). I had the 4 cycles of AC treatment then 4 cycles of the Taxol treatment. Finished chemo Jan '07. The majority of women will have very mild to moderate tingling & it usually is completely gone in 6 mos. It is called "peripheral neuropathy", it is nerve damage, in this case from drugs/toxins. I call it "chemo feet" as it is worse in my feet than hands, but I'm in the 4% group of women who get this side effect to my severity. That is a very small number 4%, so you shouldn't worry. It is also very common in diabetic patients. Most women make full recoveries. I have it, & knowing what I now know I would still do it all over again, as the alternative is even worse. I also went to the internet & did research. There are some very good websites regarding this, contrary to some opinions, but you can also scare yourself if you're not careful. There is medication that you can take for it. It just depends on the severity of it. Please feel free to email me if you have any questions about my post. Good Luck!! Answered by Fallon Demarcus 1 year ago.

Taxol (or Paclitaxel) works on all fast growing cells - cancerous or non-cancerous. Cancer is a result of uncontrolled cell division. Chemo (including taxol) inhibits these cells from dividing and puts a tab on uncontrolled growths in the body. The other fast growing cells are hair follicles and lining of the intestine. A person on Taxol is bound to lose hair and may have upset bowels. Blood cells also divide fast hence you may see an abrupt drop in your blood count which makes the immune system weak. Answered by Ricardo Jondahl 1 year ago.

The dosage I cannot guess. Taxol is given in repeated doses and numbness and tingling are the least thing to worry about. I am not going to tell you all the possible side effects, if your doctor does not want you to know them. Answered by Kelsi Hanoharo 1 year ago.

My wife had a breast removed She decided to use natural health products with excellent results that was 6 years ago Try using a product called Kinotakara chlorophyll and biogreen For further info visit my website on www.rima.k-link.co.nz Answered by Bibi Balduf 1 year ago.

I think this temporary. Ask the doctor. And be wary of people who are offering help via ....their website. Answered by Guillermina Kilbride 1 year ago.


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