Is anyone taking Sprycel and having side effects?
I've been taking Sprycel for about 6 months now and have had very few side effects from it. I know water retention and plural effusion are common with patients taking this drug. Lately though my joints, especially the small joints in my fingers and toes, have begun to swell and hurt very much. I've had...
Asked by Ilana Soliz 3 months ago.
I've been taking Sprycel for about 6 months now and have had very few side effects from it. I know water retention and plural effusion are common with patients taking this drug. Lately though my joints, especially the small joints in my fingers and toes, have begun to swell and hurt very much. I've had to remove all my rings that I wear because they simply wont fit on my swollen fingers anymore! Is anyone else taking Sprycel and having this side effect? I'm trying to figure out if this is relatively common or not before I see my oncologist next month and possibly get him concerned over nothing. I'm drinking plenty of water throughout the day and urinating on a frequent and regular basis so I feel like I can rule water retention out. Any comments are greatly appreciated! Answered by Leena Damm 3 months ago.
Is it safe to take advil or tylenol while on Sprycel??
My mom is on the chemotherapy pill Sprycel and needs to know which is safer to take.
Asked by Elisabeth Ludlam 3 months ago.
Tylenol (acetaminophen) is safe to take. Advil (Ibuprofen) has an interaction with sprycel where it can increase the risk of bleeding somewhat, most likely it wouldn't be a problem but it is always better to be safe than sorry. Hope your mother is doing well with her chemo Answered by Sha Burdg 3 months ago.
HMMMMM... ELVIS PRESLY AND MICHAEL JACKSON TOOK LIKE 100 PILLS DAILY.. AND THEY BOTH REACHED THERE 40'S OR 50'S THATS LONG ENOUGH Answered by Alisha Lufkin 3 months ago.
What are sprycel side effects?
Asked by May Adamitis 3 months ago.
Down below all you need to know Answered by Kraig Sholty 3 months ago.
Has anyone heard about sprycel for chronic myloid leukemia?
Asked by Celeste Dandridge 3 months ago.
Yes. It's for CML patients who don't respond to Gleevec or are intolerant to it. Answered by Mabel Castoral 3 months ago.
Sprycel is another in the class of oral drugs that inhibit the activity of important cellular enzymes called tyrosine kinases. The enzymes in general act like a telegraph system that pass signals in a chain to the nucleus that tell the cell to do something. In normal cells they are usually very tightly regulated but in leukemia the control is negated. The signals tell the cell to keep growing, never stop growing, spread out, ignore control signals from the body, etc. Sprycel was being developed to inhibit a family of kinases important in a number of cancers called the SRC family. Why its being used in CML is the drug also inhibits a key kinase called BCR-ABL that is the key event in the development of Chronic Myeloid Leukemia and some forms of Acute Lymphocytic Leuekmia. Sprycel inhibits the BCR-ABL kinase in a different spot than the standard drug therapy of Gleevec. It is thought that this is why the drug can be effective in cases when Gleevec stopped working or the patient cannot tolerate it. It has been used in people with CML for over 2 years. For patients in Chronic phase, over 90% of the patients have regained normal blood cell counts and about 60% appear to have only normal cells in the bone marrow. The lastest data shows that vast majority (>97%) continue to respond to Sprycel after more than 2 years of therapy. Sprycel is recommended to be taken once a day with or wothour food at a dose of 100 mg. Side effects can be similar to Gleevec with some exceptions. The drug can cause an accumulation of fluid around the lungs called plueral effusion. This can lead to some discomfort while breathing and may occur in about 20 % of cases though it is rarely serious. Many times the patient's was able to re-start Sprycel after stopping the drug until the pleural effusion had cleared. Answered by Hortencia Pelak 3 months ago.
Yes, when Gleevec fails, Sprycel is the usually the next option. It's an oral chemo drug. Answered by Ji Nik 3 months ago.
I have leukemia and taking sprycel wil it be ok to take zpack?
I have a cough and primary doctor gave zpack to take.
Asked by Renay Keir 3 months ago.
Was it a medically qualified doctor who was treating you. Answered by Maryjo Megivern 3 months ago.
You should be fine. A Z-pak is just an antibiotic. I am prone to many sinus infections, and I took quite a few Z-pack's throughout the course of my Leukemia treatment. The Z-pack usually came from my Oncologist, so he was obviously okay with it. Feel better! Answered by Linnea Jadlowiec 3 months ago.
Is my lower stomach pain a side effect of sprycel?
I know for a fact I am not pregnant!!!!!!!!!!! I just started this medicine for my CML about 3 or 4 days ago and so far I'v felt pretty gasy on it and Idk if that's just me or if it's the medicine. my lower belly hurts but not in a gas way in a way that is like everytime i walk it hurts a little. I...
Asked by Lindsay Trimis 3 months ago.
I know for a fact I am not pregnant!!!!!!!!!!! I just started this medicine for my CML about 3 or 4 days ago and so far I'v felt pretty gasy on it and Idk if that's just me or if it's the medicine. my lower belly hurts but not in a gas way in a way that is like everytime i walk it hurts a little. I think it might be fluid in my lower stomach? i'v always felt really sleepy lately and i know this is a side effect but i was on a CML medicine called Gleevce before Sprycel and that was also a side effect and i didnt feel this sleepy! i am seeing my doctor in 4 weeks and i will bring all of this up is i still feel this way but i was hoping i could get some fast answers from everyone online if they have been on this drug or are doctors or know someone who has been on it. thanks. sorry it's so long. Answered by Yon Rardon 3 months ago.
Stomach pain is a side effect, yes. That said, it may not be a normal or acceptable side effect -for you-. Call your hematologist and ask: open communication, especially when you're switching CML meds, is important. Answered by Tilda Dunsworth 3 months ago.
I have CML and my WBC has gone from 41 to 82 in just a week. Is intervenous chemo be given at this time?
Sprycel is no longer working and I've already had Gleevec and interferon in which stopped working after a while. I have a lot of bone pain and I'm on medication for that, but I would like to consider IV Chemo and wonder if that is an option.
Asked by Michele Lamper 3 months ago.
This does sound worrisome, Irish. It may be time for a bone marrow biopsy to find out what is going on. Answered by Renae Levielle 3 months ago.
Have you been informed that the WBC in CML can be cyclical going from almost normal to markedly elevated very quickly? Answered by Adolfo Townsend 3 months ago.
God Bless you with a cure. Answered by Ozell Gromoll 3 months ago.
IV chemo for CML?
Yes I was told that it can be cyclical, but the concern came when my ABL/BCR test was done out of 300 nuclei 296 were positive.
Asked by Tamala Lecates 3 months ago.
Are you on the Gleevec or Sprycel already and starting to break through? If that continues to worsen then they might be considering chemo, but I think it is usually reserved for blast crisis. It is possible that your numbers will go down again, or will respond to an increase or change in the oral medications. In case it continues to worsen, make sure that your MD has contacted a BMT doctor. Best of luck to you. Answered by Sabra Chalfant 3 months ago.
Not sure what you're referring to but the typical therapy for CML involves oral tyrosine kinase inhibitors and not IV chemotherapy. Answered by Rodrick Rassmussen 3 months ago.
Low Levels Of Enzymes Always Found In Cancer...Use The Right Enzymes To Kill Cancer Cells?
Any Natural Sources
Asked by Nidia Sanseverino 3 months ago.
Enzymes (proteins) inhibitors are probably the most effective way to treat cancer with minimum side effects. (see addendum). Targeted drug therapies like Gleevec, Sprycel and, Tasigna do that with Ph+ CML, Ph+ ALL and, GIST. These drugs act by having a higher affinity for bonding the growth substrates than the cancer proteins. This effectively inhibits the cascade of protein signals. Unfortunately, each gene produces a unique protein. So, an enzyme/protein cure for all cancers is not possible. Identification of the key cancer gene(s) for that specific cancer and it's protein produced is a difficult task in itself. Next, an inhibitor must be identified. Often times, the raw ingredient is a totally natural product. (I believe the idea for Gleevec originally came from mushrooms) This inihibitor probably must be refined for effectiveness. Then, the drug needs to be tested in cell cultures (in vitro), then in animal models and, finally in human clinical trials. Cancer is not one disease. The specific set of genetic mutations and its location defines each disease. Addendum: Kenneth C is correct. The drugs I mentioned are not proteins. They are small molecules used as TKIs. My bad. I know Gleevec is synthesized but, based on the book "Magic Orange Pill", the idea came about from natural inhibitors. Answered by Larae Lansing 3 months ago.
Use the right vitamins - Try Vitamin C therapy. A few years ago a cancer specialist came out with a paper that said the best cancer/infection fighter found to date was Interferon. At the time it was $15,000 a gram. The paper also said that Interferon was a by-product of the natural breakdown of Vitamin C in your body. Shortly after that the FDA tried to make Vitamin C by prescription only. Guess why? The FDA has the RDA for Vitamin C set at 64 mg a day, just enough to ward off scurvy. Linus Pauling, who got a Nobel Prize for his work with Vitamin C and a second Nobel Prize for Organic Chemistry, said that 1000 mg a day should be the minimum and 2000 mg a day if you are sick or smoke. He played tennis almost daily until the day he died at 96. Personally, I got sick twice a year for 2 weeks at a time, for more than 20 years, with something to this day the doctors have no idea what it was, but for a week in the middle of those 2 weeks I was flat on my back. I started Vitamin C therapy once I gave up on the doctors. I took enough to be asymptomatic for those 2 weeks. Too much and I got diarrhea and too little and I got sick. Within a narrow range, and it followed a bell curve over those 2 weeks, I was not sick. At the height I was taking 40,000 mg a day and 300,000 over the 2 weeks. After 2 years of that I have not been sick since – more than 15 years. Vitamin C acts as a natural diuretic so you need to drink a lot of water and watch your body in total, but my kidneys did not dissolve as the doctors predicted, or get massive kidney stones as other predicted. I did not dissolve my bones as some predicted or completely calcify my joints as others predicted. I had no side effects at all. It might be something to consider Answered by Nia Ingles 3 months ago.
Gleevec, Sprycel and Tasigna are not enzymes or indeed proteins of any kind. They are small molecules which were designed and synthesised from scratch to bind to certain molecules (which are proteins) in the cancer cell. The molecules which they inhibit are aberrant versions of normal cell signalling molecules called tyrosine kinases - the aberrant versions signal cells to grow and divide and to ignore normal cell death (apoptosis) inducing signals. Although cancer cell metabolism is usually abnormal, the abnormalities differ between types of cancer. This is one reason why any therapy claiming to treat, let alone cure, all forms of cancer by targeting a weakness is a hallmark of snake-oil. I am a haematology biomedical scientist by training and have an MSc in clinical oncology. Answered by Nia Aagaard 3 months ago.
My husband was just diagnosed with cml....?
He is only 26 years old. He starts treatment In January what is his life expectancy? The oncologist says they found it very early. His WBC was 20,000.
Asked by Cole Deases 3 months ago.
I was diagnosed with CML a bit younger than your husband, and I decided to go for a stem cell transplant after long-term oral treatment with gleevec and sprycel. I was originally diagnosed in accelerated phase, but managed to get my counts down to chronic level before undergoing chemo and transplantation. I am alive and healthy 1 year post transplant, and I don't have CML anymore. Some people can live decades on just the oral medications, and some younger people decide to go ahead and undergo transplantation as transplantation is curative in CML. These are things to talk about with his doctor. If his doctor is not an expert in myeloproliferative disorders, find the nearest doctor who is, and ask them what experience they have in dealing with younger CML patients- the expectations and treatments when you're under your 50s-60s with CML understandably need to be different. And start researching transplant centers in your area and their services and track records, because when you're as young as we are with CML, chances are you'll need 'em. Feel free to email me if you have more questions (you can do so by clicking my profile and selecting the email option) as I do have quite a bit of experience dealing with this disease as a younger person. Answered by Slyvia Scace 3 months ago.
Sorry to hearken to that my chum. My best chum had leukaemia and the treatment presently is astonishing- the way they look once you is in basic terms stunning. technologies is so stepped ahead that many of the painful treatments and procedures of only many years in the past at the prompt are not needed. there is an extremely good environment on the wards- the nurses and ward team are the most impressive people you'll ever meet. Its all about preserving your spirits up and a good body of recommendations. regrettably treatment generally lasts a lengthy time period, yet in basic terms shop rolling with the punches and be keen to get by. good success! Answered by Nakesha Linkhart 3 months ago.