How effective is sorafenib 200 MG (organic name NEXAVAR) IN Malignant melanoma?
my father is 52 years old & has been diaognised with maligant melanoma ! doctors says that as liver is effected by the disease surgery will be of no use ! so they suggest for palliative treatment & started giving interferon to him & also ask us to arrange for new medicine SORAFENIB/NEXAVAR as it is not available in...
Asked by April Cyrulik 6 months ago.
my father is 52 years old & has been diaognised with maligant melanoma ! doctors says that as liver is effected by the disease surgery will be of no use ! so they suggest for palliative treatment & started giving interferon to him & also ask us to arrange for new medicine SORAFENIB/NEXAVAR as it is not available in INDIA & very costly too ?can some body tell us abt its effect specifically in melanoma ? & secondly any other possible, better treatment/medicine for this disease? pls reply early Answered by Enda Jadoo 6 months ago.
Sorafenib is a targeted drug therapy. It is a small molecular inhibitor of Raf kinase, PDGF (platelet-derived growth factor) and VEGF receptor kinase. Other current PDGR, VEGF and, EGFR inhibitor drugs such as Iressa, Tarceva and Avastin have provided some benefit to a select group of patients. These are pretty much anti-angiogenesis drugs. Most of these drugs have been approved for specific cancers Avastin for colon cancer, Iressa for long cancer, Nexavar for kidney cancer. However, these drugs are also used in clinical trials and off-label. Nexavar for melanoma would be off label. Again, the benefits shown so far have been limited for the approved cancers. So, there is little to no data collected for non-approved cancers. When these targeted therapies were designed, they had a rationale of their method of action and a disease location in mind. So, trying these drugs for other cancers is close to a total shot in the dark. I wish I had a better answer but, advanced melanoma is a very difficult to treat disease. From what I've read, there are very encouraging results in the treatment of melanoma from some clinical trials involving engineered vaccines. I know alot of the work is being done at NCI and JHU. I'm not sure if that can help you. Answered by Elicia Tecklenburg 6 months ago.
I'm sure you would receive a Moore actuate answer from a doctor. what do you think? Answered by Heike Saulter 6 months ago.
Is Sorafenib available in India?
Hi please someone tell me is Sorafenib available in India, if not the how can I purchese it and how? I dont have much time , please... Please inform me, I heard it helps to be cured from Liver Cancer.
Asked by Alyssa Kuzel 6 months ago.
Sorafenib, marketed as Nexavar by Bayer India Ltd, is a drug approved for the treatment of advanced renal cell carcinoma (primary kidney cancer) and also Kuver cancer. It has also received "Fast Track" designation by the FDA for the treatment of advanced hepatocellular carcinoma (primary liver cancer), and has since performed well in Phase III trials. This medicine is not being manufactured in India, but Bayer India Ltd., import it from their overseas counterparts and sell it. It is a rarely available medication in India. So Please contact Bayer (India) Ltd., at Bombay and they may be able to help you even by getting it imported. - Answered by Danyel Nino 6 months ago.
off course Sorafenib 200 Mg tablets is Available in India As different Different Trade Names Like Sorafenat 200 Mg : Sorafenib manufactured by Natco Soranib tablets manufactured by Cipla Etc Oddway International is WholesAle Price Exporter & Supplier Of All Cancer Medication WorldWide We Also Deals In gefitinib Tablets , Imatinib , Sorafenib , Erlotinib tablets generic And Branded medication Also Call us for Bulk Order +91-9873336444 Or email Us : i[email protected] Answered by Ferdinand Patella 6 months ago.
Not sure about where sorafenib is available but you could write directly to the company that manufactures this type of chemotherapy. They have a program available to help out patients called the Reach program. Answered by Rob Maciel 6 months ago.
If sorafenib is in india ....at which cost it get....how long it take for liver canser?
Asked by Lashaun Jaques 6 months ago.
Sorafenib is a drug available in many countries. If your doctor thinks you need it they will administer it to you. You should not be concerned with finding your own drugs. Answered by Asia Milleson 6 months ago.
Where can I find articles that pertain to kinase inhibitors imatinib, birb-796, pd166-326, sorafenib, etc?
I am doing research on kinase inhibitors for a specific set of enzymes and I need IC50 data. What are the best search perameters I should set to narrow my field? I have tried pubmed but I need the full text, not abstracts.
Asked by Kam 6 months ago.
Try PubMed.org If you're a student, your school may have free access to many of the articles. Answered by Lucia Radatz 6 months ago.
Is anyone taking sorafenib because of thyroid cancer?My mom has been taken it for 4 months and she'll continue?
has anyone taken sorafenib for more than 5 months because of thyroid cancer?
Asked by Willette Janik 6 months ago.
Is she taking if for Medullary thyroid cancer or is she on the Clinical trial for poorly-differentiated thyroid cancer? I've heard of it being taken for a longtime with the former. Answered by Alvaro Hartery 6 months ago.
Sorafenib for liver cancer?
is anybody takin the medication 4 liver cancer n 4 how long,side effects n has it help,anybody gotten off it
Asked by Syble Weekey 6 months ago.
I’m sure the side effects are listed on their website, but obviously not everyone get them. Patients are taken off when it is no longer working. Sorry but The Raschal’s ex did not have liver cancer and would not have taken this drug. Answered by Damien Nelms 6 months ago.
What is the medical drug Sorafenib used to treat liver, renal and other cancers?
Asked by Vincenzo Sanker 6 months ago.
IT IS USED TO TREAT KIDNEY,LIVER,BRAIN,THYROID,LUNGS CANCER IT INHIBITS TYROSINE PROTEIN KINASE ,WHICH INACTIVATES THE CANCER CELLS ITS SIDE EFFECTS ARE SKIN RASH,LOOSEMOTION IT IS GIVEN FOR ADVANCED CANCER Answered by Davida Riemenschneid 6 months ago.
How can the polaxamer molecule be used to increase the water solubility of drugs?
such as sorafenib? any ideas? thanks so much!
Asked by Garnett Kirsopp 6 months ago.
This answer is a bit different than what Cat indicates. Poloxamer is a surfactant as indicated. Sorafenib is fairly water insoluble because it has many nonpolar functional groups. So poloxamer is both soluble in both water and some nonaqueous solvents. Now the goal is to add poloxamer to the drug to make a solution to a solid of the poloxamer-drug-poloxamer 3-d structure. As this sees water... the poloxamer is water soluble and the drug in the middle of the poloxamer gets taken up into the water. THE GOAL IS TO INCREASE THE AMOUNT OF DRUG INTO THE BODY, NOT INTO ANY CELLS (BIOAVAILABILITY). :) Usually at some point the poloxamer and the drug is separated but at this point it is stable enough in the body. This is very similar to how liposomes work for drugs like Caelyx®, Myocet®, Ambisome(R), and Doxil(R). Answered by Harvey Sportsman 6 months ago.
If a drug is water soluble meaning regardless of the physique would not use or want that's for sure excreted interior the urine. Take to illustrate supplements which comprise nutrition C. that's water soluble so which you're able to have it in abundance by way of fact to any extent further would be excreted interior the urine. Answered by Barney Helbing 6 months ago.
The poloxamer molecule is actually a surfactant; it reduces the surface tension of what it is in contact with. This will aid penetration of the drug into the cell membrane. That appears to be one way to get the drug into a cancer cell. Answered by Yvonne Yanda 6 months ago.
Hi please someone tell me is Sorafenib available in India, if not the how can I purchese it and how? I dont ha?
Asked by Lizabeth Koestner 6 months ago.
I doubt anyone here would know what is available in India. Why don’t you ask your doctor? They will need to prescribe it anyway. Answered by Lessie Laffoon 6 months ago.
Liver cancer at age 75?
My father is diagnosed with Hepata cellular carcinoma-HCC, (Liver cancer). His age is 75. He has 7.5 cm X 4 cm tumor and several small tumors in his liver.Symptoms: 1. Weight Loss :Lost 10 kg weight since one year. Still loosing weight. 2. Abdomen pain3. Soure taste, vomiting sensation - unable to...
Asked by Marlo Marren 6 months ago.
My father is diagnosed with Hepata cellular carcinoma-HCC, (Liver cancer). His age is 75. He has 7.5 cm X 4 cm tumor and several small tumors in his liver. Symptoms: 1. Weight Loss :Lost 10 kg weight since one year. Still loosing weight. 2. Abdomen pain 3. Soure taste, vomiting sensation - unable to eat. 4. If taken solid food, irritation in stomach and has to clear his bowls. Today started SORAFENIB 200 mg two times a day. His soure taste and vomiting sensation increased. SORANIB 200 mg Indian version (CIPLA company) which contains SORAFENIB. 1. Does this CIPLAs Soranib 200 (low cost. 30 tablets Rs.1710) works. (SORAFENIB OR NEXAVIR Costs around Rs.2500 each tablet) 2. My second question does this liver cancer is curable or manageable at his Age 3. Explain me about the pain management. 4. Any proven alternate treatment Answered by Roberta Paramo 6 months ago.