SAPHRIS Ressources

Application Information

This drug has been submitted to the FDA under the reference 022117/001.

Names and composition

"SAPHRIS" is the commercial name of a drug composed of ASENAPINE MALEATE.

Answered questions

Success stories with Saphris?
This will be my fifth antipsychotic in a year, and I'm honestly getting discouraged. Any success stories? "Unsuccess" stories are welcome too, though. I wanna know what I'm getting into. Asked by Ardis Meuler 6 months ago.

Asenapine( Saphris)is used to treat symptoms of psychotic (mental) disorders, such as schizophrenia, or mania or bipolar disorder. This medicine should not be used to treat behavioral problems in older adult patients who have dementia. This medicine is available only with your doctor's prescription. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. Using this medicine with any other medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects. It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for any unwanted effects. Along with its needed effects, a medicine may cause some unwanted effects.Check with your doctor immediately if any side effects occur. Take care as always! Answered by Robbi Goodspeed 6 months ago.

Saphris and Clozaril ?
How do they work seperate and together? Please Let me Know. Thank You & God Bless! Asked by Betty Gernert 6 months ago.

Saphris is an antipsychotic medication. It works by changing the actions of chemicals in the brain. Clozaril is an antipsychotic medication. It works by changing the actions of chemicals in the brain. Clozaril is used to treat severe schizophrenia symptoms in people who have not responded to other medications. It is also used to help reduce the risk of suicidal behavior in people with schizophrenia or similar disorders. These meds have interactions if used together: CNS depression, tardive dyskinesia, tachycardia, and ECG changes. Anticholinergic effects of these agents may also be additively increased. Excessive anticholinergic effects may result in paralytic ileus, hyperthermia, heat stroke, and the anticholinergic intoxication syndrome. Peripheral symptoms of anticholinergic intoxication commonly include mydriasis, blurred vision, flushed face, fever, dry skin and mucous membranes, tachycardia, urinary retention and constipation. Central symptoms may include memory loss, disorientation, incoherence, hallucinations, psychosis, delirium, hyperactivity, twitching or jerking movements, stereotypy and seizures. Please read the following website, you may want to talk to a pharmacist and your doctor about it though. Answered by Marinda Sleiman 6 months ago.

Just from a quick wiki check both are Atypicals used in the treatment of schizophrenia Clozaril is older and Saphris is the new shiny toy. I am not sure how they work separately. Answered by Gayla Domenice 6 months ago.

How would you compare the sedation and weight gain effects of saphris compared to medications like clozaril or?
risperadal? Asked by Floyd Gowing 6 months ago.

You Definitely Sam, Me I've been advised I seem like Valerie Bertanalli a couple of instances, But on that celeberty seem a like factor it stated I appeared like Jami Lyn Spears LoL in case anybody does not recognise Brittneys litle sister, 35 yrs or so older off the bat simplest factor I can consider of is our pointie chins lol Answered by Thurman Lauzier 6 months ago.

Does paxil make you gain weight? Does Saphris? What about lamictal?
Actually LC I am on max dosages of all three. I am on high blood pressure medicine too. Asked by Tonia Durham 6 months ago.

Saphris?!!! That is adangerous drug, Beth, do you HAVE to take it? Paxil as far as I know is safer, my mother takes iy and she has a history of weight problems but has not gained on this medication. I wi;ll have to look up lamictal. be very careful to keep an eye on blood pressure with saphris, god i hate those type of drugs they do not promote healing they just do chemical reactions in your brain. Answered by Gisela Vignovich 6 months ago.

Has Saphris (asenapine) improved your life?
Did you have any bad side-effects? If so, how long into treatment? What dosage works best for you? thank you. Asked by Shawnta Parris 6 months ago.

I love Saphris! I tried Seroquel, Abilify, Geodon... all with horrible side effects. With the Saphris I did gain a little weight at the beginnig but it stopped after about 10 lbs... other than that the only side effect is the nasty taste and a little numbing of the tongue. I sleep better than I have in my entire life! And not like Lunesta where I slept so hard I slept throuh my smoke alarm, it is like perfectly normal sleep... no hangover.... nothing. I love it. And it does a bang up job keeping the mania in control without making me feel like a zombie. Horribly expensive but it is so worth it! Answered by Jeffrey Sitar 6 months ago.

I've never taken it. I noticed from various sites that in rare cases, Tardive Dyskenisis (involuntary muscular movement) can occur. If this disorder takes hold, there is no cure. I would consult a doctor about any medicine that can cause this disorder. If you catch Tardive developing early enough and stop taking the medication, the Tardive can eventually go away. Answered by Marlena Moree 6 months ago.

Question about Saphris medication (Long but please, please read)?
My sister takes Saphris for her bipolar and I think because she hallucinates a lot. She takes it at night because it knocks her out, but her doctor told her to take half of one in the morning too since she hasn't stopped hallucinating and her mood swings are getting worse. Well, taking it in the morning is... Asked by Chantelle Zaza 6 months ago.

My sister takes Saphris for her bipolar and I think because she hallucinates a lot. She takes it at night because it knocks her out, but her doctor told her to take half of one in the morning too since she hasn't stopped hallucinating and her mood swings are getting worse. Well, taking it in the morning is making her extremely tired. We went out to eat and she fell asleep, we went to see Man of Steel and she fell asleep (I don't know how she could stay asleep during the movie), we saw The Purge today because she was begging mom to take her to see it and she fell asleep, she fell asleep playing her favorite video game, she fell asleep in the car and wouldn't wake up so dad had to carry her inside and we went to the pool and she fell asleep there too. When she's not asleep she's all quiet and jumpy because she's seeing even worse hallucinations than before (she told me this). She doesn't like taking the Saphris in the morning because of how it makes her feel. She loves to write stories and sing, but her medicine makes it so that it's hard for her to get out of bed. She always plays games with me but now she stops after 20 minutes so she can nap which really worries me. Before when she only took it at night, I would wake her up in the morning and she could barely talk or open her eyes and when she tried to get out of bed I'd have to help her or make her sit up until she was awake enough to move without falling. Now, when she's up I try to have a conversation with her but she responds after a really long pause and usually gives me two or three words at a time. I hate seeing her like this and sometimes it makes me cry because I just want my sister back. Is the medicine supposed to do this? Is there anything else she can take that won't make her tired all the time? Should she just stop taking it all together? Answered by Christa Garlett 6 months ago.

My doctor prescribed Saphris for my Bipolar II but I couldn't take it for long because it gave me terrible orthostatic hypotension. He prescribed another atypical antipsychotic, Abilify. I have taken it for two years. I'm on the maximum dosage and have had no side effects. There is another atypical antipsychotic out there with a minimum side effect profile called Latuda that she might be able to take. I don't think that this sleepiness is a normal side effect of medication. It's one that is interfering with her daily life enjoyment, and y'all need to talk to her doctor and see if there is an alternative medication she could take that will stop the hallucinations and calm the mania. Is she on a mood stabilizer such as Lithium or Lamictal/Lamotrigine? This would help with the mood swings. Get her in to see the doctor ASAP and discuss a change in medication. This should help. Answered by Shan Ohms 6 months ago.

First of all I have sympathy for both you and your sister. I am bipolar myself but I do not hallucinate. If she has worse hallucinations than before she got on the medication this should be brought up to the psychiatrist. As far as drowsiness goes this may also be a problem with the medication and should be discussed. On the other hand every medication has a side effect (trust me I'm on them) and as a family member you need to weigh your options. It's either medication side effects or mental hospital. Both are very difficult but at least medicated she's still in your life. Answered by Gigi Rinderknecht 6 months ago.

I suggest she tells the doctor about the side effects sooner rather than later. Ultimately it is your sister's choice whether to use the meds or not. The doctor may be able to suggest a better alternative. I suggest praying for her- it can't hurt, and may help. Answered by Pok Ozaki 6 months ago.

Anyone ever try Invega or Saphris?
I am currently taking Citalopram (Celexa) 20mg, Invega 6mg and not sure about but have Trazodone 50mg for sleep is it safe with the combo. I take this for Schizoaffective Bipolar 1 Disorder Asked by Young Hanna 6 months ago.

Just wondering if anyone had ever been on Invega or Saphris. Which one works better or what was positive or negative about the meds. Im taking invega now i tried saphris made me tired and shakey but worked better in first couple of days than invega has in a 3 days. no side effects from invega yet except a little nauseus, and dizziness. any info will help thanks Answered by Margurite Granroth 6 months ago.

Invega is just risperdal repackaged so it can be sold for big bucks, since risperdal went off patent. It is the first active metabolite of risperdal, which means it is the drug that your body converts risperdal into in the liver. So you may as well take risperdal, it is generic now, and less expensive, unless you are just using samples. I wouldn't recommend saphris to anyone unless they were desperate - that drug has not been on the market very long - you want to be a guinea pig? the rule of thumb is to wait until a drug has been on the market for 7 years or more before taking it, unless it's a breakthru med or you've failed on all the other meds. those fda trials are short - only 3 to 6 weeks. The fact that zyprexa makes you blimp out and gain 60 pounds or more in a few months - that was somehow overlooked until it had been on the market for a few years. just one example. many drugs get pulled off the market in that 7 year window. risperdal does help quite a few people. if you take antispychotics, you MUST get your blood sugar checked regularly, in case you start to develop diabetes, your cholesterol and triglycerides, and should weigh yourself regularly and have EKG's to check for heartbeat abnormalities (I don't know if you need those regularly, or just once after you've been at a therapeutic dose for awhile). psychiatrists don't order these tests, even though many of them are in the black box warnings on antipsychotic drugs, I guess. I just read less than 1/3 of patients are told to get their blood sugar and cholesterol and triglycerides checked. make sure you don't overheat in the summer - heatstroke is much more likely on these meds. If you keep up on getting the lab tests, if you do develop problems from the medication, those problems will be caught in time, so you are not likely to get permanent problems. you do have to keep in mind how severe the mental illness itself is, in weighing risks and benefits. If you have mild to moderate depression, antipsychotics are not appropriate, but for schizophrenia, bipolar crises, or depression crises, they are. in bipolar or depression, usually antipsychotics should be tapered off when the crisis is over - mood stabilizers for bipolar or antidepressants for depression are the treatments of choice for those conditions. all the best Answered by Raymond Farnan 6 months ago.

Saphris Recreational Answered by Maximo Poutre 6 months ago.

As she shakes her fist And shouts in rage The torrents of rain Drip onto this web page As she appears to the clouds And stares on the sky The droplets nonetheless fall correct into her eye Her screams are muffled No you will pay attention As the thunder explodes And deafens their ear The rain will retain While the shaman holds his rod After the virginal sacrifice To the strong Rain God It was once a problematic rite Followed through the orgy and soiree Do you know the way difficult it's To uncover a virgin in these days? Answered by Aide Guardino 6 months ago.

don't take poison, i got over 50 side effects from it and i am dying from it. Answered by Myles Debuhr 6 months ago.

What's been your experience with Saphris?
I have mixed bipolar. I am currently taking Seroquel but, it doesn't seem to be doing enough. My psychiatrist wants me to switch to Saphris. Does anyone have any personal experience with the drug? Asked by Julio Manspeaker 6 months ago.

I like Saphris very much and I have tried Seroquel, Abilify, Geodon too. The taste is absolutely nasty... it's sublingual - you have to let it disolve under your tongue and can't rinse your mouth out for 10 minutes... Your lips and tongue go a little numb..... also I had a little increased appetite but was careful and didn't gain any weight. Other than that It works well..... Seroquel made me suicidal, Abilify worked but caused severe insomnia, Geodon worked but caused severe anxiety... Everyone is different but I do like Saphris the best. Answered by Buddy Dederich 6 months ago.

Can I take saphris with methadone?
what interations? Decrease in effectivness Asked by Sunday Brailsford 6 months ago.

Here's what I got from a drug-drug interaction checker: methadone ⇔ asenapine Applies to: methadone, Saphris (asenapine) MONITOR CLOSELY: Methadone may cause dose-related prolongation of the QT interval. Coadministration with other agents that can prolong the QT interval may result in elevated risk of ventricular arrhythmias, including ventricular tachycardia and torsade de pointes, because of additive arrhythmogenic potential related to their effects on cardiac conduction. High dosages of methadone alone have been associated with QT interval prolongation and torsade de pointes. In a retrospective study of 17 methadone-treated patients who developed torsade de pointes, the mean daily dose was approximately 400 mg (range 65 to 1000 mg) and the mean corrected QT (QTc) interval on presentation was 615 msec. The daily methadone dose correlated positively with the QTc interval. Fourteen patients had at least one predisposing risk factor for arrhythmia (hypokalemia, hypomagnesemia, concomitant use of a medication known to prolong the QT interval or inhibit the metabolism of methadone, and structural heart disease), but these were not predictive of QTc interval. It is not known if any of the patients had congenital long QT syndrome. MANAGEMENT: Caution is recommended when methadone is administered concomitantly with drugs that prolong the QT interval, particularly in the setting of chronic pain management or methadone maintenance for opioid dependency where high dosages may be employed, or if administered to patients with underlying risk factors. Patients should be advised to seek medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, palpitations, or syncope. If taking drugs that also cause central nervous system and/or hypotensive effects (e.g., psychotropic drugs like tricyclic antidepressants, phenothiazines, and neuroleptics), patients should be made aware of the possibility of additive effects with methadone and counseled to avoid activities requiring mental alertness until they know how these agents affect them. But ultimately speak to your doctor first. Answered by Cherish Garzia 6 months ago.

No, you need to ask your doctor. Narcotic medication such as levomethadyl (Orlaam), or methadone (Dolophine, Methadose). are listed among the drugs that can interact with asenapine Please see the link below for the complete list. Answered by Gertrude Kloiber 6 months ago.

I'm bipolar and was recently put on a medication called saphris aka asenapine . This is a rather new drug in t?
This is about the medication saphris aka asenapine . Looking for information from people. Asked by Rudy Duignan 6 months ago.

Unless this drug is a miracle drug for you, it is not worth the risk to be a human guinea pig. the risks of this drug are not known very well yet - it takes years before most of the risks are discovered, and drug companies actively work to suppress this information, as a routine way of doing business. the rule of thumb that I have seen many times, in fact, i think I even read it in consumer reports, is to make sure a drug has been on the market for at LEAST 7 years before you try it, unless it is a breakthru drug (which saphris is not) or you have exhausted all your other options. the drug companies covered up how zyprexa routinely causes 50+ lbs weight gain, as one example - docs were really ticked off. But then they still invite these drug reps in their offices and prescribe their new drugs when the doc has no idea what the risks are. they seem not to learn. I would recommend you go to and read more, and get this author's book at the library. I exhausted my treatment options (tried 25+ drugs over 15 years and ECT, and most made me worse or did nothing but give me side effects) so I had nothing to lose, and gave up. I just use my light box, exercise, try to do nice things for myself (fished more this summer, for example). And I am somewhat more functional than the past 7 years or so, and more important, have lost the having to claw my face off feeling that I had (literally) for hours every day of my life for many years. So it appears that at least some of the intolerable "bipolar" symptoms were actually medication side effects. Now the bipolar is more like when I was younger - I still can't work, still depressed as hell, etc., but not so desperate to die. my 2 cents anyway. the lying drug company stuff isn't controversial - it's well documented. the 7 year rule of thumb is also nono-controversial and is for all kinds of drugs, not just psych drugs. Answered by Gregory Sveen 6 months ago.

I've been taking Saphris for about 6 months and I love it... I tried Seroquel, Abilify, and Geodon, all with side effects that were not bearable. It causes a bit of hunger but that tapers off after a couple of months so if you can bear it it does go away.... also the taste is horrible! They are supposed to be coming out with a black cherry flavored one but my pharmacy can't find it.. it seems to be on perpetual back order.... so for now I tolerate the taste. It works very well for me and helps with both the depression and the mania... I am more stable than I have been in many years. Seroquel made me suicidally depressed, Abilify made me severely manic, Geodon worked but caused akathesia and anxiety and panic attacks... I do love Saphris. Answered by Bernardo Lostroh 6 months ago.

Psychiatrists claim that a person needs a drug to combat their chemical imbalance in the brain which is causing a persons mental disorder. However, the concept that a brain-based, chemical imbalance underlies mental illness is false. As with all of psychiatric disease models, it has been thoroughly discredited by researchers. -Quakery exposed. Please dont waste your time with labels and so called "cough" "Mental Problems". They dont exist in a biological way. "They vote on disorders and then they become diseases" " Its total fraud" -- Dr. Fred Baughman Neurologist Negative words are abuse, and bullies/parents abuse/ignoring can make children grow up with all types of so called "Mental Problems" or turn them into abusers. They are hurt and pass it on. Jesus name is needed for healing with forgiveness. God wants you to know truth, forgive, and get away from them. Read many many sites under "emotional abuse" and "dealing with bullies". Source(s): Experience with people feeling better repeatedly without pills --Talk to me. I have some questions for you. Answered by Mario Macgregor 6 months ago.


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