What is the difference between immunosuppressive drugs and rituxan?
is the steroid prednisone considered an immunosuppressive drug?
Asked by Lucienne Gaulding 3 months ago.
Rituxan is a type of immunosuppressive drug; these drugs have a lot of different ways they suppress the immune system. Rituxan's specific mechanism of action is to bind to the CD20 receptor on B-lymphocytes which eventually leads to the cell's death. So Rituxan is targeted to B-cells (a type of lymphocyte)--and yes, it does kill off the lymphocytes that produce antibodies. Here is more detailed information from Lexi-comp online: Rituximab is a monoclonal antibody directed against the CD20 antigen on B-lymphocytes. CD20 regulates cell cycle initiation; and, possibly, functions as a calcium channel. Rituximab binds to the antigen on the cell surface, activating complement-dependent B-cell cytotoxicity; and to human Fc receptors, mediating cell killing through an antibody-dependent cellular toxicity. B-cells are believed to play a role in the development and progression of rheumatoid arthritis. Signs and symptoms of RA are reduced by targeting B-cells and the progression of structural damage is delayed. Prednisone is considered an immunosuppressive drug; it actually belongs to a class of drugs called corticosteroids, and the way these drugs work their many effects is by suppressing the immune system. Here is more detailed information on this from Lexi-comp: prednisone decreases inflammation by suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability; suppresses the immune system by reducing activity and volume of the lymphatic system; suppresses adrenal function at high doses. Antitumor effects may be related to inhibition of glucose transport, phosphorylation, or induction of cell death in immature lymphocytes. Actually, in reading this (last sentence specifically)--it looks like they're saying predinsone may actually have some cytotoxic (cell-killing) activity--I didn't know that. More than likely, if you're talking about a immunosuppressive drug, it generally does just suppress the immune system, and doesn't kill off anything. For example, another monoclonal antibody (like rituximab) is basiliximab; this one works in this way: "Chimeric (murine/human) monoclonal antibody which blocks the alpha-chain of the interleukin-2 (IL-2) receptor complex; this receptor is expressed on activated T lymphocytes and is a critical pathway for activating cell-mediated allograft rejection." That's from Lexi-comp of course because I didn't quite remember how it worked off-hand. But as you can see, this one blocks interleukin-2 which is part of the pathway that enhances the action of the immune system. By blocking this, the immune system is *suppressed*--thus the term "immunosuppressive drugs". Cellcept belongs to another class of drugs that are immunosuppressives (and not cytotoxic--just cytostatic). There are a great many ways immunosuppressive drugs work, those are just a few examples. Hope all this helped some! Answered by Myrtie Martes 3 months ago.
Is rituxan a chemotherapy drug?
Asked by Lacy Parthemer 3 months ago.
Rituxan (rituximab) is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Rituxan is used to treat non-Hodgkin's lymphoma or chronic lymphocytic leukemia. Rituxan is also used in combination with another drug called methotrexate to treat symptoms of adult rheumatoid arthritis. Rituxan is also used in combination with steroid medicines to treat certain rare disorders that cause inflammation of blood vessels and other tissues in the body. Answered by Fonda Bendzus 3 months ago.
Rituxan is used to treat non-Hodgkin's lymphoma or chronic lymphocytic leukemia. Rituxan is also used in combination with another drug called methotrexate. So. yes... Answered by Hana Chesnutt 3 months ago.
Where can we buy Rituximab or Rituxan in the Philippines?
My sister's son is really ill the chemotherapy drug is not working. According to the doctor Rituximab is needed. We looked at the leading drugstore here in the Philippines but can't find any. Thank you very much for any information that could lead us to where we could buy it! (Philippines)
Asked by Catherina Boie 3 months ago.
Rituxan is an anticlonal antibody that targets only the tumor, not the surrounding tissue or body. It works well only with certain cancers. It is given IV (intravenous), is by prescription only, and needs to be given in a clinic or drs. office. That's why you can not get it at a drugstore. I think your sister must have misunderstood that you could buy it in a drugstore. Have her bring her son back to the Dr. so this drug can be administered. Good Luck to your nephew! Answered by Neoma Gividen 3 months ago.
Buy Rituximab Answered by Holley Helwig 3 months ago.
Can anyone tell me about Rituxan therapy?
I am going to start Rituxan therapy only for my Non-Hodgkin's Lymphoma. Can anyone tell me what I might expect for side effects?
Asked by Desire Horsch 3 months ago.
WARNING: FATAL INFUSION REACTIONS, TUMOR LYSIS SYNDROME (TLS), SEVERE MUCOCUTANEOUS REACTIONS, and PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY (PML) Infusion Reactions: RITUXAN administration can result in serious, including fatal, infusion reactions. Deaths within 24 hours of RITUXAN infusion have occurred. Approximately 80% of fatal infusion reactions occurred in association with the first infusion. Carefully monitor patients during infusions. Discontinue RITUXAN infusion and provide medical treatment for Grade 3 or 4 infusion reactions. Tumor Lysis Syndrome (TLS): Acute renal failure requiring dialysis with instances of fatal outcome can occur in the setting of TLS following treatment of non-Hodgkin's lymphoma (NHL) with RITUXAN monotherapy. Severe Mucocutaneous Reactions: Severe, including fatal, mucocutaneous reactions can occur in patients receiving RITUXAN. Progressive Multifocal Leukoencephalopathy (PML): JC virus infection resulting in PML and death can occur in patients receiving RITUXAN. Answered by Rosaria Persechino 3 months ago.
Never heard about Rituxan therapy Answered by Zetta Neish 3 months ago.
Should I treat my Hairy Cell Leukemia with Rituxan?
I had a treatment of Cladribine for Hairy Cell Leukemia in August. My post-treatment bone marrow results show that there are 30% of Hairy Cells left. My doctor proposed treatment with Rituxan. What are the side effects and how often do they appear? Are there more common side affects than others? Are they as bad as...
Asked by Nakisha Sanderfur 3 months ago.
I had a treatment of Cladribine for Hairy Cell Leukemia in August. My post-treatment bone marrow results show that there are 30% of Hairy Cells left. My doctor proposed treatment with Rituxan. What are the side effects and how often do they appear? Are there more common side affects than others? Are they as bad as they sound? After my first treatment of Cladribine my immune system was very weak, will it weaken again after Rituxan? Will I be able to work? If I decide to go through with it, treatments will end around December, will I be safe with a weak immune system? Are there any alternative treatments, that will less weaken my immune system, or are there any safer treatments in general? If I end up choosing Rituxan, do I have to immediately start or can I wait a couple of months? Thank you, I'll be waiting for an answer. I would greatly appreciate your opinion. Answered by Donya Manders 3 months ago.
Most people here are not oncologists. This is an issue for you to discuss with your oncologist - not with us. He or she should be explaining the pros and cons of Rituxan therapy. I always explained the pros and cons for my patients when planning a new treatment. Discussions take a great deal of physician time, but I think it is an essential part of the job. Medicare encourages doctors to run patients through in assembly line fashion. I don't think it can or should be done that way. One of the reasons I retired early was the business aspects of medical practice. That part - sorry to use this word - sucked. There were no business courses in med school. The bureaucracy of Medicare, Medicaid , and 3rd party insurance companies was an aggravation I did not need and the patient did not need. I do admire the British/U.K. system which takes the business off the backs of the doctors. We already have socialized medicine in Medicare and Medicaid. It is not a great stretch to include every citizen so we can focus on patient care and not whether they can pay for it. I know - I switched to a different topic, but that Rituxan will be ridiculously expensive. Has that been explained to you ? - - - - I'd like to acknowledge that "formerly" has an excellent answer. Answered by Amparo Tallacksen 3 months ago.
Like most drugs, there's a list of potential side effects of Rituxan and you really can't predict which side effects you will experience or how severe the effects will be. Most people at least feel like they have the flu for several days after the treatment, and some of these people will feel very sick. Rituxan also carries a small risk of a fatal allergic reaction soon after the injection but this risk is nearly eliminated by close monitoring of the patient and using antihistamines or steroids if necessary. You should plan on being out of commission for maybe 3-4 days, although some people don't have any significant side effects and they are good to the following day. Rituxan looks to be highly effective for hairy cell leukemia, so that's a good reason to consider it. If you have a history of frequent hives or multiple food allergies, you might want to bring this up with your doc and ask if this is likely to make you more likely to experience negative side effects since most of the side effects are caused by allergic reactions. The drug does not have much negative effect on disease-fighting capabilities, and it might even increase immunity to diseases and it reduces inflammatory responses. The risks are similar to risks with the alternative drug in this class (interferon) and probably less than those with chemotherapy. So, this is probably as low a risk as is available except for forgoing treatment. In many cases, hairy cell leukemia does not need to be treated, so unless it is causing you to experience severe symptoms, there is probably no urgency. You might ask your doctor if taking the drug right away has an advantage over waiting since starting now would begin with a lower count of cancer cells. Maybe this doesn't matter. Answered by Charise Dusett 3 months ago.
My dr wants me on rituxan after chemo,how long will i have to be on it and are there side affects?
Asked by Barb Swainston 3 months ago.
Rituxan therapy can result in serious side effects, some which can be life-threatening. These include: infusion reactions tumor lysis syndrome (TLS) severe mucocutaneous reactions progressive multifocal leukoencephalopathy (PML) Other serious, potentially life threatening side effects are: hepatitis B infection that may become active again serious infections heart problems low blood cell counts Answered by Lauren Labarriere 3 months ago.
I was suppose to start my period on the day I got my first Rituxan Iv for Arthritis. But it has been 5 days since then and I still havent started. I am 18 and am not sexually active. So there is no chance I am pregnant. I usually have a regular monthly cycle sometimes a day late. Can this IV have caused this?
Asked by Karren Shirvanian 3 months ago.
These side effects may go away on their own as your body becomes used to the Rituxan. Let your doctor or nurse know if any of them are causing you problems or do not go away on their own. Stomach pain or back pain Diarrhea Change in your taste buds Dry eyes Loss of appetite or heartburn Pain in your joints or muscles Numbness or tingling in your hands and feet Feeling depressed or trouble sleeping Special Notes Changes in your menstrual cycle or sperm count may occur. Discuss birth control measures with your doctor as it is not advisable to conceive or to father children while taking this drug. Answered by Zula Altic 3 months ago.
Has anyone had side effects from Rituxan therapy? If so what were they and what helped to control them?
I am going through Rituxan treatments for cancer. My Doctor and Medical team have repeatedly assured me that there are NO side effects from Rituxin, but I feel awful during and for a week or so after. I feel depressed, anxious, paranoid and totally incapable of handling everyday tasks that are no problem for me...
Asked by Valentin Kung 3 months ago.
I am going through Rituxan treatments for cancer. My Doctor and Medical team have repeatedly assured me that there are NO side effects from Rituxin, but I feel awful during and for a week or so after. I feel depressed, anxious, paranoid and totally incapable of handling everyday tasks that are no problem for me before & after treatment. If anyone out there went (or is) going through Retuxin treatments and having similar or any type of side effects. Please tell me what you have done or are doing for them. Thank you in advance. Answered by Enoch Sherfield 3 months ago.
Hi. I have not had Rituxan therapy, but I know a lot of people who have. What you're describing is very unusual. Are you on any other medication, or did you complete chemotherapy and maybe are recovering from that? I assume you have lymphoma. I truly do not think your problems are from Rituxan (although everyone has a different reaction to medication). Share this information with your doctor. Answered by Roseanna Bartosz 3 months ago.
It is possible for any number of side effects to occur with a specific therapy. While what you describe is not a common side effect of rituximab (Rituxan) treatment, they are potential uncommon side effects of the therapy (see website below). Just because you develop side effects to a treatment does not mean you should stop. You should continue to bring up your symptoms with your doctors and decide what the best course of action should be. For example, since your symptoms appear more psychologic in nature, it is possible that an anti-depressant of some sort may help. On the other hand, more medications means more potential for other side effects. So you would have to weigh the risks and benefits. Answered by Ivey Fredricks 3 months ago.
I really had no problems from Rituxan. Now, CHOP on the other hand... Check with your oncologist about your symptoms. Best wishes to you! Answered by Cecily Goist 3 months ago.
Can anyone give me any advice on Rituximab / Rituxan?
I am 20 years old, I have been diagnosed with Lupus (SLE) for seven years now. I have been on a variety of medication including prednisone, cellcept, plaquanil, immuran, and even cytoxan which is another iv chemotherapy type medication. After my last treatment of cytoxan I had been on remission for a little over a...
Asked by Joe Mendez 3 months ago.
I am 20 years old, I have been diagnosed with Lupus (SLE) for seven years now. I have been on a variety of medication including prednisone, cellcept, plaquanil, immuran, and even cytoxan which is another iv chemotherapy type medication. After my last treatment of cytoxan I had been on remission for a little over a year, just to find out a month ago that I am going through a flare again. My doctor wants to start me on Rituximab/Rituxan because he believes that is the only way to stop my flare since the other medications do not seem to be working. After going through cytoxan I am actually really scared on being put on another iv treatment, the effects were horrendous and just by thinking about it makes me sick to my stomach. I have heard the effects of Rituximab/Rituxan are not as bad however I would appreciate if anyone can give me feedback if you have been on this medication or know someone that has, is it really bad? I am coming to the end of the semester, I am currently a junior in university, my gpa is rather great and I would not like this to affect my school activities. Therefore I would like to know how Rituximab or Rituxan affects everyday life when given to you. Thank you so much for your help in advance and I hope someone is able to help me, I am truly going to appreciate it! Answered by Tenisha Culley 3 months ago.
I have SLE and I also work with lupus patients. Rituxan is a chemotherapy that was designed to treat non-Hodgkins lymphoma. It has also proven useful in treating lupus that does not respond well to the therapies you already tried. I personally know 3 patients who have taken Rituxan. They do report some of the side effects that you read about. One of them was my teaching partner for a 6 week workshop. She did manage to teach throughout that time, but fatigue was certainly an issue. However, it's hard to tell if the fatigue was from the Rituxan or the lupus itself. Ask your rheumatologist if he/she has other patients who would be willing to sit down and share their experiences with you. Also realize that just as lupus affects each one of us differently, so do the medications. Best of luck to you! Answered by Laurel Reinhold 3 months ago.
Here is a link to a site that talks about Rituximab/Rituxin. It tells about dosage, possible side effects,etc. Just remember one important thing while you are reading it. Everybody is different. No two people react the same to a drug treatment. I hope everything works out for you :) Answered by King Shen 3 months ago.
What are the possible side effects of rituximab (Rituxan)? Some people receiving a rituximab injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel dizzy, weak, nauseated, light-headed, itchy, or if you have a fever, chills, muscle pain, sneezing, sore throat, trouble breathing, or pain in your chest or shoulders. Infusion reactions often occur within the first 24 hours after the start of your rituximab infusion. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Rituximab increases the risk of a serious viral infection of the brain that can lead to disability or death. This risk is higher if you have a weak immune system or are receiving certain medicines. Call your doctor right away if you have symptoms such as change in your mental state, problems with speech or walking, or decreased vision. These symptoms may start gradually and get worse quickly. Call your doctor at once if you have any of these serious side effects, even if they occur several months after you receive rituximab, or after your treatment ends. * sudden numbness or weakness, especially on one side of the body; * confusion, dizziness, loss of balance, blurred vision, and problems with speech or walking; or * chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling; * uneven heartbeats, wheezing or trouble breathing; * urinating more or less than usual; * fever, chills, cough, body aches, flu symptoms; * easy bruising or bleeding; * a red, raised, blistering, scaly, itchy, or peeling skin rash; * severe constipation or stomach pain; * black, bloody, or tarry stools; or * nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Less serious side effects may include: * pain where the IV needle is placed; * headache, back pain; * mild stomach pain, nausea, or diarrhea; * swelling in your hands or feet; * muscle or joint pain; * runny or stuffy nose; or * night sweats. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. What is the most important information I should know about rituximab (Rituxan)? Do not receive this medication if you have ever had a severe allergic reaction to rituximab, or if you are allergic to mouse protein. Some people receiving a rituximab injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel dizzy, weak, nauseated, light-headed, itchy, or if you have a fever, chills, muscle pain, sneezing, sore throat, trouble breathing, or pain in your chest or shoulders. Infusion reactions often occur within the first 24 hours after the start of your rituximab infusion. To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled appointments. If you have hepatitis B you may develop liver symptoms after you stop using this medication, even months after stopping. Your doctor may want to check your liver function at regular visits for several months after you stop using rituximab. Do not miss any scheduled visits. Rituximab increases the risk of a serious viral infection of the brain that can lead to disability or death. This risk is higher if you have a weak immune system or are receiving certain medicines. Call your doctor right away if you have symptoms such as change in your mental state, problems with speech or walking, or decreased vision. These symptoms may start gradually and get worse quickly. Answered by Sol Sheirich 3 months ago.
hi there! i love my slow cooker and usually cook the same meal....Beef strogonoff, which takes up to six hours to cook, obviously the slow cooker cooks things at a much much slower pace than anything else but you will definitley notice a difference in the meat that your cooking! - soooo much nicer, all i can suggest is that you prepare your food many hours before you want to eat it, (ps if you cook sausages in there they dont change colour, they look like they're not cooked because they're still a pinky colour, but left in for long enough - they are cooked) hope this helps? Answered by Felipa Fredric 3 months ago.