Application Information

This drug has been submitted to the FDA under the reference 017788/001.

Names and composition

"RIMSO-50" is the commercial name of a drug composed of DIMETHYL SULFOXIDE.


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Answered questions

Is urea a component of DMSO?
Asked by Kacy Stroope 1 year ago.

Dimethyl sulfoxide (DMSO, RIMSO-50) was the first of two therapies approved by the US FDA for the treatment for IC in the early 1970's. Its use has quickly diminished due to the growing popularity of rescue Instillation's and research that suggests that DMSO can be damaging to the bladder muscle. Many clinics no longer use DMSO treatments. IT ISN"T A GOOD IDEA to have DMSO Tx in my opinion, I had them, made it worse then before! It burns the bladder, and originally was used on animals! If your question relates to having treatments, I strongly suggest to get a second opinion, but if it is for lab testing/experiments, I doubt it very seriously, a waste product of urine would be part of a compound placed into the bladder. I'm saying "no" from what I know. :o) DMSO is a dilute, sterile, and purified version of a chemical that was used for many years as an industrial solvent before being found to have anti-inflammatory, analgesic, muscle relaxant, mast cell stimulation and collagen dissolution properties. Urological Association suggests that DMSO may cause damage to the muscle of the bladder when used at the 50% dosage. In "DMSO - Does it change functional properties in the bladder wall" researchers tested various concentrations of DMSO on strips of bladder muscle to try to determine what, if anything, the DMSO did to muscle. They found that DMSO triggered intense muscle contractions and, at doses higher than a 30% solution, caused what appeared to be long-lasting contractions that could be irreversible. Since the normal FDA approved dosage used for humans is 50%, researchers suggested that the dosage be reduced to, at most, 25% to avoid any possibility of muscle damage. It is dissolved in blood and excreted by the kidney as a component of urine. In addition, a small amount of urea is excreted (along with sodium chloride and water) in sweat. UREA is a waste product, I doubt it would be part of a DMSO cocktail for humans, but maybe in animals it may have some purpose? Answered by Roxanna Correale 1 year ago.

No. And FWIW, DMSO has a big hazard warning on it that says: "MSDS recommends wearing safety glasses because DMSO can cause chronic damage to the eyes.[9] Glove selection is important when working with DMSO. Thick rubber gloves are recommended." Answered by Enedina Scheidel 1 year ago.

No, but the compounds are similar. Urea is a s double bonded to an O, and flanked by two nh2 (amine) groups. DMSO is flanked by two methyl groups instead. Answered by Leann Lovstad 1 year ago.

Are anti-inflammatories such as ibuprofen or prednisone useful in treating IC?
Asked by Diedre Smutnick 1 year ago.

Well, we do not exactly know the caue of interstital cystitis (IC.) There are theories that it could be autoimmune, neurologic, allergic, genetic, etc. Since it is some sort of inflammatory process, anti-inflammatories such as NSAIDs (ie. ibuprofen) and even steroids are helpful, usually in mild diseases. With a very mild case, you can start with dietary modification such as decreasing the intake of highly spiced or acidic foods, alcohol, coffees, teas, herbal teas, green teas, all sodas, concentrated fruit juices, tomatoes, citrus fruit, cranberries, B vitamins, vitamin C, monosodium glutamate, and chocolate. More severe disease may require narcotics for the pain, TCAs, astingents (ie. silver nitrate), transcutaneous electrical nerve stimulation (TENS), which uses mild electrical pulses to relieve pelvic pain and, in some cases, reduce urinary frequency or undergoing cystoscopy with bladder distention. Drugs, such as dimethyl sulfoxide, or DMSO, (Rimso-50) placed into your bladder sometimes is mixed with other medications, such as a local anesthetic may also be helpful. If All else fails, sugrery may be necesssary: ■Bladder augmentation. In this procedure, surgeons remove the damaged portion of the bladder and replace it with a piece of the colon, but the pain still remains and some women need to empty their bladders with a catheter multiple times a day. ■Fulguration. This minimally invasive method involves insertion of instruments through the urethra to burn off ulcers that may be present with interstitial cystitis. ■Resection. This is another minimally invasive method that involves insertion of instruments through the urethra to cut around any ulcers. Answered by Scottie Enrriquez 1 year ago.

IC is interstitial cystitis. It's a long term inflammation of the bladder wall. Ibuprofen may be beneficial in patients with mild discomfort associated with IC. The use of prednisone can be effective in improving symptoms, especially pain, in some patients with ulcerative IC who have failed to respond to standard therapies. Answered by Benito Steinmuller 1 year ago.

prednisone is not really anti inflammatory it is a steroid that works by suppressing the immune response Answered by Lesley Borgen 1 year ago.

what's IC?? Answered by Effie Kristek 1 year ago.

I have the constant need to go pee when i really dont?
and when i do go pee towards the end its hurts a couple time there has been little bit of blood what do you think it is? Asked by Nathanael Chacko 1 year ago.

See your health care provider as soon as possible. Interstitial cystitis is a bladder inflammation but infection is not to blame. Like a urinary-tract infection, the disease can provoke frequent, urgent urination. Unlike an infection, it often causes pain that is actually relieved by urination. No one knows what causes interstitial cystitis, and diagnosis can be difficult. There is no cure, so treatment focuses on symptoms. Many approaches have been tried, including distending the bladder with fluid; infusing the bladder with a chemical called DMSO (Rimso-50); aqnd giving oral medications such as pentosen (Elmiron), the antidepressant amitriptyline (Elavil), and various muscle relaxants for the bladder. None has worked consistently. I hope this helps you. And good luck. Answered by Nannie Amadi 1 year ago.

kidney/bladder infection. See a Doctor. Answered by Terrance Simo 1 year ago.

UTI, urinal tract infection, is very common, antibiotics is the cure Answered by Kelsey Bui 1 year ago.

Those are your mostly likely things, if that isn't it then check into diabetes testing. Answered by Johnie Paradise 1 year ago.


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