Application Information

This drug has been submitted to the FDA under the reference 009053/002.

Names and composition

"PURINETHOL" is the commercial name of a drug composed of MERCAPTOPURINE.


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Answered questions

What are the companies that producethe purinethol?
i have achilde that suffers from leukemia for 2 years and his medication including purinethol to prevent relapse of the disease and i cannot find the drug her in my country so please i want to know what are the companies that produce this drug and how can i obtain a large amount of this drug for my son? Asked by Karma Kresse 2 years ago.

PURINETHOL (mercaptopurine) is a potent drug. It should not be used unless a diagnosis of acute lymphatic leukemia has been adequately established and the responsible physician is knowledgeable in assessing response to chemotherapy. PURINETHOL (mercaptopurine) was synthesized and developed by Hitchings, Elion, and associates at the Wellcome Research Laboratories. It is one of a large series of purine analogues which interfere with nucleic acid biosynthesis and has been found active against human leukemias. Answered by Connie Dicorcia 2 years ago.

Is there a generic drug for Purinethol (Mercaptopurine)?
Where is the cheapest place to get it with a prescription if I will be paying for it out of pocket with no RX insurance benefit. Asked by Nova Desanctis 2 years ago.

Mercaptopurine is the generic of Purinethol. It's very expensive, though. Your best bet is to call all of your local pharmacies and go with the one that has the best price. Answered by Shonta Gammell 2 years ago.

Does Mercaptopurine (aka Purinethol) interact with Ortho-Cyclen birth control?
And is it safe to take the Mercaptopurine in the morning and drink alcohol at night? (I am taking it for Lupus) Asked by Charla Mcmains 2 years ago.

Mercaptopurine Oral Back to Drug Overview Thiopurines/Allopurinol; Oxypurinol This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. Medical warning: Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information. How the interaction occurs: When these two medicines are taken together, your body may not process thiopurines properly. What might happen: The blood levels of your thiopurine may increase and cause toxic effects such as fever, chills, easy bruising or bleeding, black or tarry stools, blood in urine, or mouth or lip sores. What you should do about this interaction: Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these two medicines together. They may already be aware of this drug interaction and may be monitoring you for it. If you develop any of the symptoms above, contact your doctor. It may be necessary to adjust the dose of your medicine. Do not start, stop, or change the dosage of any medicine before checking with them first. no you should not be drinking with that type of medications Answered by Hal Schroedter 2 years ago.

WBC slightly low, causes?
my last blood work showed my WBC to be slightly low, was good last year. Dr was not concened. what can cause this? Asked by Charlena Molinari 2 years ago.

White Blood Cell (WBC) count and Differential White blood cells (also called leukocytes) are your body's mobile defense system against infections. Like a SWAT team, white blood cells travel in the bloodstream to areas of infection and destroy harmful bacteria. A normal WBC count is 4.8 - 10.8 thousand cells per cubic millimeter, but varies from day to day depending upon the circumstances. The WBC count can be temporarily decreased when the body defends itself against a viral infection such as the common cold. A low WBC is an expected side effect of some medications such as Imuran and Purinethol, often used to treat inflammatory bowel disease such as ulcerative colitis and Crohn's disease. A low WBC count (leukopenia) is the norm during chemotherapy treatments. Like all blood cells, WBCs are made in the bone marrow. Chemotherapy selectively focuses its killing power on rapidly dividing cells, such as cancer cells. That is how it kills cancer cells and not the patient. Unfortunately, the cells in the bone marrow also divide rapidly and are attacked by most chemotherapy agents and the WBC count falls. If it drops too low, chemotherapy is temporarily halted while the bone marrow recovers. A high WBC count (leukocytosis) is often found when the body is attacked by more serious infections such as bacterial pneumonia or diverticulitis. It is not unusual to see values around 15,000 to 30,000 during a serious bacterial infection. As the infection responds to antibiotic treatment, the WBC count quickly returns to normal. An extreme elevation in the WBC count is seen when cancer of the blood cells develops, a serious condition called leukemia. In this instance the WBC may be well over 100,000. Not all WBCs are the same. In fact, there are five different types of white blood cells that together make up the total WBC count. Some are better at fighting infection while others focus on supporting the immune system. Others may be involved in allergic reactions. If the doctor orders a CBC with differential, or smear, the lab will break down the WBC count into the different types of white blood cells. This information is sometimes useful in determining the type and severity of an infection, allergic reactions, and other blood disorders. AND Here is a discussion on Health Boards: Question hi ! well this is my first time on Healthboards, and I am here to see if I can help one of my BEST friends out. Well, my friend is LOW on his White Blood Cells. Does anyone know how serious this is, and do you guys know how to increase your WBC and what to do and not do to improve the situation? THANK YOU GUYS SO MUCH for taking your time in reading this. I would really HOPE that you guys will REPLY to this. THANKS ! =] Answer: Low white cell counts can be caused by chronic infection, recent regemin of antibiotics, for no reason in particular, and of course AIDS, and lymphomas. The most common reason is that some people do not absorb Vitamin B-12 and Folic Acid well and that cuts down on the formation of white blood cells. You can go pretty low on WBC's as long as the ones you have are healthy and have all the necessary immunity against opportunistic infections. Answered by Karlene Villalobos 2 years ago.

Causes Of Low Wbc Answered by Dinorah Oberbeck 2 years ago.

This Site Might Help You. RE: WBC slightly low, causes? my last blood work showed my WBC to be slightly low, was good last year. Dr was not concened. what can cause this? Answered by Carole Sadee 2 years ago.

Don't be scare,if your doctor not concern most like only slight low.Some virus infection such as a common cold. will lower your wbc.If you concern wait a while and ask repeat the test. Answered by Katina Jakubczak 2 years ago.

Crohn's Disease and Remicade?
He has improved tremendoulsy on this medication. He has been taking it every 6 weeks for almost a year now. He is, however; skeptical of the side effects. His doctor has told him that Remicade has caused TB in some people. Well now he thinks that he will get it and not be able to be around me or our boys (3 and... Asked by Joshua Begeman 2 years ago.

He has improved tremendoulsy on this medication. He has been taking it every 6 weeks for almost a year now. He is, however; skeptical of the side effects. His doctor has told him that Remicade has caused TB in some people. Well now he thinks that he will get it and not be able to be around me or our boys (3 and newborn) which I think is silly to worry about what could happen insead of appreciateing the good days! But then again, I am not the one with the disease, I'm just a care giver and it's very hard on me to see him hurting like that. I would like him to continue as long as it's working. It's just that not a lot of people have had exp. with Remicade, heck most of the people that we know don't even know what Crohn's Disease is. Answered by Reda Boven 2 years ago.

I was diagnosed with CD 16 years ago, and started getting Remicade infusions every 7-9 weeks about 4 years ago. It's helped quite a bit to keep the disease under control. Your husband needs to make sure that he takes a benadyrl (or equivalent) and tylenol right before the infusion so that any side effects are minimized. The nurse should give him this. Research has shown that remicade is more effective over the long term if you continue to take immunosuppressives such as 6-mp (mercaptopurine/purinethol) or similar meds while you are undergoing Remicade therapy. In addition, if a person gets infusions, stops getting infusions, and then starts getting them again after a period of more than one year, the remicade won't be as effective. It's an expensive drug. Hopefully you have good insurance. When I went to the endoscopy center for my infusions, my co-pay was something like $1500 a time! My doctor and I figured out that, with my insurance, it was better for him to write me a prescription so that I could pick up the Remicade at my local pharmacy and then carry it (in a cooler) to his office where one of his nurses administers the IV. I only have to pay a $30 co-pay for the Remicade, and a $30 co-pay for the office visit. I do have to order the Remicade through the pharmacy a week ahead of time so that it can be ready when I need it, but that's an easy thing to do. My doctor is an hour away from where I live, and I tried to find a local hospital or treatment center where I could get the infusions, but none of them were willing to do so because of liability issues of me bringing the remicade. They were worried that I wouldn't keep it refrigerated properly, but my doctor has been my doctor since I was diagnosed, so he knows that I'd follow the directions with the meds. Anything else you want to know? Just add on to this question, and I'll try to answer for you. Answered by Marquitta Whitecotton 2 years ago.

I also suffer from Crohn's and I had 3 injections of Remicade about 8 yrs ago. It didn't work for me and I now have an ileostomy. Has his experience been ok so far? Answered by Lavinia Pheonix 2 years ago.

Puri-nethol (mercaptapurine)?
SECOND NOTE: I said I'm NOT looking for a list of symptoms. Please read the questions properly. Asked by Anika Pietschman 2 years ago.

Hello, I've been put on a 6 month course of a drug called Puri-nethol (you may know it as Mercaptapurine) and I wanted to hear any side-effects that other users have experienced while using it. I understand that alot of these things are a bit personal, but there is a certain level of anonymity here, so anyone who's willing to share their symptoms it would be appreciated. PLEASE NOTEL: I don't want to be given a list of the possible symptoms. I know them. I have researched the drug thoroughly. What I am after is symptoms that real people have gotten. I'd like to get responses from people who are or have been on the drug and have experienced the symptoms for themselves. Thank you. Answered by Irish Delagrange 2 years ago.

I am on mercaptopurine for my Chrons. Is there any harm in my stopping taking it (because of side effects)?
I am 48, and have fairly sever Chron's. My doctor has had me on Asacol, and at times prednasone, but none of it has slowed down the Chrons. About 3 weeks ago, he started me on Mercaptopurine (Purinethol, or 6mp). I have not had any of the benefits yet, but have had very unpleasant side effects (loss of appetite... Asked by Earline Marti 2 years ago.

I am 48, and have fairly sever Chron's. My doctor has had me on Asacol, and at times prednasone, but none of it has slowed down the Chrons. About 3 weeks ago, he started me on Mercaptopurine (Purinethol, or 6mp). I have not had any of the benefits yet, but have had very unpleasant side effects (loss of appetite & weight, stiffening of joints, and considerable shortness of breath). He suggested I stop the 6mp, at first I disagreed, thinking I wanted to give it a chance to work. But now I would like to stop - the only problem is I can't reach him for two more days. So I have not taken the medicine today, and just wonder if it is okay to simply stop taking the medicine, or if I should be doing/taking something else also. Thank you. Answered by Janine Vicory 2 years ago.

You shouldn't have any problems stopping the medication. If you feel fine today after not taking, continue not taking it and when you can reach your doctor, tell him you have discontinued. Whatever you do, do not try to "catch up" on the doses, if you decide to take it. That can cause severe side effects including respiratory arrest. Considering your side effects and the fact that the doctor has suggested stopping the medication, I think you'll be fine with not taking it. Good luck finding a med. that works! Answered by Edris Bertuzzi 2 years ago.

What is the treament for chrons disease
Asked by Kourtney Maloff 2 years ago.

Treatment focuses on relieving symptoms of the disease by inducing and then maintaining remission. This is accomplished by prescribing medicines that reduce the inflammation in the intestinal tract. Common drugs used to treat Crohn’s disease are aminosalicylates, steroids, antibiotics, anti-TNF agents, and immunomodulators. The cornerstone for inducing remission in severe Crohn's disease continues to be oral or intravenous corticosteroids such as prednisone. They also have a role in managing less severe disease and in treating small bowel involvement. They are used for short-term therapy and other medications are used to maintain remission following steroids. Steroids work by reducing inflammation throughout the body and thus long-term use is associated with many side effects like osteoporosis, diabetes, and hypertension. Promising results have been obtained with the use of budesonide (Entocort), a corticosteroid with high topical anti-inflammatory activity and low systemic activity (because of extensive hepatic metabolism). This medication, though costly, can reduce the intestinal inflammation while minimizing the side effects that would commonly be experienced with prednisone. Another category of drugs often used in Crohn’s disease is the topically acting 5-aminosalicylates such as mesalamine (Asacol, Pentasa), sulfasalazine (Azulfidine), and balsalazide (Colazal). These medicines are quite safe, but may require large doses. Antibiotic agents, such as metronidazole may be helpful in perianal and/or colonic Crohn’s disease. How antibiotics help Crohn’s disease is not well understood, but the benefit may be the result of altered concentrations of bacteria in the colon and small bowel. Immunomodulatory drugs such as azathioprine (Imuran, Azasan), 6-mercaptopurine (Purinethol), or methotrexate are often effective in maintaining remission of Crohn's disease. These medications are used long-term and require monitoring to prevent adverse effects. They work by changing the way certain inflammatory cells in the intestinal lining respond to inflammatory triggers. Infliximab (Remicade) is a powerful anti-inflammatory drug that blocks the action of a specific molecule called tumor necrosis factor (TNF), a key mediator of the inflammatory process in Crohn’s disease. It is indicated for perianal Crohn’s disease or intestinal disease not responding to the usual first-line medications. This drug is actually a synthetic antibody and is given as an intravenous infusion for both induction and maintenance of remission. Important side effects of this medication are infusion reactions (rash, fever) and, rarely, serious infections. Other medications known as biologicals, of which infliximab is one, are being studied and may emerge as viable therapies for Crohn’s disease in the future. Despite advances in the medical treatment of Crohn's disease, surgery may be necessary to remove the diseased segment of bowel. Surgery is usually reserved for those in whom medical treatment has been ineffective. Other indications for surgery may include: permanent narrowing or an obstruction of the bowel development of a fistula between an involved segment and the bladder, vagina or skin infection in the area of the anus perforation of the bowel abscess (localized infection) within the abdomen Surgery will result in remission but does not represent a cure of the disease. Most patients will have a recurrence of Crohn’s disease after surgery and thus will require additional medical therapy. Despite the serious nature of the disease, treatment often permits the person with Crohn's disease to lead an active and productive life with a normal lifespan. Dietary changes have not been shown to help treat Crohn’s disease because diet does not appear to reduce the inflammation in the intestines. Because weight loss is common when Crohn’s disease is active, it is important that patients maintain a healthy diet with adequate caloric intake. However, weight gain may only be successful after reducing the inflammation with prescription medications. If the bowel becomes narrowed (strictured) because of chronic Crohn’s disease activity, then patients may be at risk of bowel obstruction. In this case, a low residue diet that eliminates non-digestible vegetables may be recommended. For all patients, stopping smoking is an important part of any therapy for this disease. Answered by Tami Petrusky 2 years ago.

Yes... it's spelled chrohn: Crohn's sickness (sometimes called nearby enteritis) is a protracted, episodic, inflammatory situation of the gastrointestinal tract characterised through transmural irritation (affecting the complete wall of the worried bowel) and pass lesions (locations of irritation with locations of ordinary lining in among). Crohn's sickness is a style of inflammatory bowel sickness (IBD) and will impact any facet of the gastrointestinal tract from mouth to anus; consequently, the indicators of Crohn's sickness can fluctuate among affected members. The most important gastrointestinal signs are stomach soreness, diarrhea, that may be bloody, and weight reduction. Crohn's sickness too can rationale headaches external of the gastrointestinal tract akin to epidermis rashes, arthritis, and irritation of the attention Answered by Eveline Cherrez 2 years ago.

What is allopurinol medication?
medication Asked by Veronica Howell 2 years ago.

GENERIC NAME: allopurinol BRAND NAME: Zyloprim, Aloprim DRUG CLASS AND MECHANISM: Allopurinol is used for treating gout caused by excessive levels of uric acid in the blood (hyperuricemia). Uric acid is a by product from the breakdown of certain proteins (purines) in the body. Hyperuricemia occurs when the body produces more uric acid than it can eliminate. The uric acid forms crystals in joints (gouty arthritis) and tissues, causing inflammation and pain. Elevated blood uric acid levels also can cause kidney disease and stones. Allopurinol prevents the production of uric acid by blocking the activity of the enzyme that converts purines to uric acid. Uric acid levels usually begin to fall within 2-3 days of starting treatment and return to their original levels within 7-10 days after allopurinol is stopped. It may take several months of therapy before attacks of gout are controlled. The FDA approved allopurinol prior to 1982. PRESCRIPTION: Yes GENERIC AVAILABLE: Yes PREPARATIONS: Tablets: 100, 300 mg; Powder for injection: 500 mg STORAGE: Tablets should be stored at room temperature between 15 to 25 C (59-77 F) and in a moisture proof, light- resistant container. Powder should be stored between 20 and 25 C (68-77 F) and not refrigerated. PRESCRIBED FOR: Allopurinol is used for treating acute attacks of gout, erosive destructive gouty joint disease, uric acid deposits in tissues (tophi), gouty kidney disease, and uric acid stones. Allopurinol also is used to prevent elevation of blood uric acid in patients undergoing chemotherapy for the treatment of certain cancers and in patients with recurrent calcium kidney stones and elevated uric acid levels. DOSING: The dose range of allopurinol is 100-800 mg day. It should be taken with food to avoid irritation of the stomach. In order to avoid formation of kidney stones, patients should drink plenty of fluids while taking allopurinol. DRUG INTERACTIONS: Allopurinol increases blood levels of oral mercaptopurine (Purinethol) and azathioprine (Imuran) by reducing their breakdown in the body. Therefore, the dose of mercaptopurine and azathioprine should be reduced in order to avoid toxicity. There is an increased risk of skin rash in patients taking allopurinol in combination with penicillins. PREGNANCY: There are no adequate studies of allopurinol in pregnant women. NURSING MOTHERS: Allopurinol is excreted in breast milk. To avoid adverse effects in the infant, nursing mothers taking allopurinol should consider not breastfeeding. SIDE EFFECTS: Common reactions include diarrhea, nausea, rash and itching, and drowsiness. The most frequent side effect to allopurinol is skin rash. Allopurinol should be discontinued immediately at the first appearance of rash, painful urination, blood in the urine, eye irritation, or swelling of the mouth or lips, because these can be a signs of an impending severe allergic reaction that can be fatal. Allopurinol should be avoided by patients with a prior severe reaction to the drug. Allopurinol can cause a flare-up of gouty arthritis during initial therapy. Therefore, colchicine often is used simultaneously to prevent these flares. Rarely, allopurinol can cause nerve, kidney, and bone marrow damage. Allopurinol can cause a serious allergic liver toxicity that can be fatal. Appetite loss and itching can be signs of liver toxicity. The risk of this reaction increases in patients with kidney impairment. Patients with kidney impairment should receive lower doses of allopurinol. Answered by Faustina Metoyer 2 years ago.

The problem with allopurinol medication is that their designed on the basis of “interruption” mechanism. Xanthine oxidase inhibitors disrupt the purine – uric acid cycle by suppressing the enzyme that helps to break down purine to uric acid. Look, God created xanthine oxidase to help us dispose the excess purine in the body. The degradation of purine happens in the liver, and the end product which is uric acid is released back into the bloodstream to be sent to the kidneys for disposal. Blocking this cycle with allopurinol causes the built up of purine in the liver which leads to all sorts of side effects. Answered by Antionette Antonetty 2 years ago.

It reduces uric acid production and is used to Prevent (not treat) gout. In fact it will make acutr gout worse. It needs to be started when the patient is free from acute gout, started at a low dose (50mg) and increased slowly. Answered by Jeri Firsching 2 years ago.

it blocks the production of uric acid which precipitates in the joints as crystals, which are needle like and cause a lot of pain and swelling. This is known as gout. Answered by Lucille Maiava 2 years ago.

neutralizes uric acid in the system....treats gout. Answered by Corina Yager 2 years ago.

No it doesnt to my knowledge. I am on allopurinol, coreg, spironolactone, diovan, and several others with no side effects! Answered by Idella Sewald 2 years ago.



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