PEGINTRON Ressources

Application Information

This drug has been submitted to the FDA under the reference 103949/001.

Names and composition

"PEGINTRON" is the commercial name of a drug composed of PEGINTERFERON ALFA-2B.

Answered questions

Whats the side effect of using uniferon? how about pegintron?
Asked by Devon Corless 3 months ago.

The most common side effects of pegintron are flu like symptoms, fatigue, anemia, low white blood cell count, injection site tenderness or rash, depression. Actually the anemia is from the ribavirin which are the pills taken with the weekly shots. Can't help you with the uniferon because it's not approved here in the US, but I assume since it's interferon alpha 2b, like the drug rebetron, the side effects will be similar to that. The side effects for rebetron are the same as pegintron, only more severe. The pegylation makes it metabolize differently and thus not as intense when it comes to side effects. Hope this helps. Answered by India Endorf 3 months ago.


Is there any adverse effects when taking pegintron and lamictal ?
Asked by Luigi Nicolette 3 months ago.

well, you are taking the lamictal for bi-polar i suppose. this might need to be increased on your treatment with pegintron. they might also have to add an antianxiety medication as well. pegintron can put you in an aggrivated and depressed state. it is a side effect. the good news is that if you make it through treatment, you might find that your diagnoses of being bipolar might subside! you didn't state what the treatment is for, but if it is for hepatitis b or c and you respond, you might not ever need your lamictal again....viruses do pass the blood brain barrier, along with toxins the liver is not able to filter. could be why you've were diagnosed as beging bi-polar. i was depressed from the age of 12/13 until treatment with interferon and ribavirin. the only reason why i was approved is because a good doctor understand the relationship between viral infections and the mind. without the virus there more than likely would be no depression. as far as i am a ware of, the medications you are taking should be okay, but something else might need to be added or your lamictal might need the increase as you get further along in your treatment. if you notice your symptoms of bi-polar increasing it is just a side effect of the pegintron. ask your doctor and see what he thinks. Answered by Sung Kreitzbender 3 months ago.


Are there better medical cures for Hepatitis C than Ribavarin/Pegintron or analogues from other manufacturers?
I have the treatment for 12 months that did not work. Asked by Desiree Shabazz 3 months ago.

Unfortunately Ribavarin/pegintron is the best FDA approved generally available treatment. There are new treatments currently in research that are likely to be improvements over Ribavarin/Pegintron. These may be available to you as part of a research trial. The website "the body" has a great Q&A website about Hepatitis infection. The website is mostly about HIV and HIV/Hep C coinfection. I still think that you will find alot of useful information in their Hep C sections. Good luck, hope that this was helpful. Answered by Shawana Marcinko 3 months ago.

There is no cure for Hep C. There are treatments to deal with the symptons and prolong quality of life for those infected with it BUT there is NO cure. There is also no vaccine though there is for Hep A and Hep B. Answered by Bettina Oullette 3 months ago.

Look into a Japanese tea- SST, or silymarin- usually in milk thistle, or Arbidol- a Russian herbal compound Answered by Connie Woelfle 3 months ago.

I found some good info here. Answered by Essie Huckabaa 3 months ago.


Any suggestions for coping with the side affects of pegintron/ribovirin treatment for HepC?
I have hepc and cirrhosis. I went on the treatment about 2 yrs ago, but was unable to tolerate it. I'm going to start treatment again, but this time I will start with only interferon and if I'm doing okay, then they will introduce a small dose of ribovirin. I am a patient of Calif Pacific Med Cntr and will... Asked by Keenan Schulder 3 months ago.

I have hepc and cirrhosis. I went on the treatment about 2 yrs ago, but was unable to tolerate it. I'm going to start treatment again, but this time I will start with only interferon and if I'm doing okay, then they will introduce a small dose of ribovirin. I am a patient of Calif Pacific Med Cntr and will probably need a transplant in about 3 yrs. Does anyone know of anything that will help with the horrible side affects? They want me to try to stay on the interferon for a year!! Also, if you have hepc and cirrhosis, do you have almost unbearable pain in muscles and joints? My pain is intense. What does your doctor prescribe for pain? Answered by Maudie Classen 3 months ago.

i have had hep c for 7 years i have tried interferon with ribovirin then pegintron with ribovirin and the side effects are very bad, my dr prescribed 800mg of ibuprofen some drs disagree with the ibuprofen but it worked for me and has not made my liver worse. one specialist told me to stay away from tylenol not that it helped me anyway, i also suffer from severe joint and muscle pain on most days it is so painful to just move, i have been to numerous drs in 2 states and i honestly believe either they do not know enough about hepc or they just do not care people are still very ignorant when it comes to hep c they think right away you used drugs,this is not always the case. i would advise you to speak with your dr about the ibuprofen it helped me with the side effects when i was on treatments and helps me now with the muscle and joint pain i have to do what works for me cause i have a 16 year old who depends on me i cannot be laid up in bed all day cause of the the pain, i wish you lots of luck and i feel for you cause i am going thru the same thing Answered by Leighann Mar 3 months ago.


Are rebetol and pegintron forms of chemotherapthy?
my dad has hep c. and was taking rebetol/pegintron combo injections and he keeps refering to it as his chemotherapy. but nothing i've read about it says its a cancer treatment. he keeps telling me he has cancer. and that it is his cancer treatment. Asked by Kellie Cangiano 3 months ago.

These are not chemotherapy for cancer, but rather for hepa C: PEG-Intron, peginterferon alfa-2b, is indicated for use alone or in combination with REBETOL (ribavirin, USP) for the treatment of chronic hepatitis C in patients with compensated liver disease who have not been previously treated with interferon alpha and are at least 18 years of age. REBETOL (ribavirin, USP) Capsules and Oral Solution are indicated in combination with INTRON A (interferon alfa-2b, recombinant) Injection for the treatment of chronic hepatitis C in patients 18 years of age and older with compensated liver disease previously untreated with alpha interferon and in patients 18 years of age and older who have relapsed following alpha interferon therapy. Hepatitis C: * Chronic infection: 55%-85% of infected persons * Chronic liver disease: 70% of chronically infected persons * Deaths from chronic liver disease: 1%-5% of infected persons may die * Leading indication for liver transplant Answered by Janette Pellegren 3 months ago.

Rebetrol and PEG-intron are the standard treatment fot hepatitis C. Some people like to use different nomenclature because it makes them feel better. Interferon is sometimes used for cancer and other diseases. But by and large, chemotherapy is reserved for cancer treatments. Hepatitis C also causes hepatomas (liver cancer) and he may be suffering from that. Answered by Bebe Ficke 3 months ago.


Are rebatol and pegintron forms of chemotherapy??
Asked by Jaye Priebe 3 months ago.

These are not chemotherapy for cancer, but rather for hepa C: PEG-Intron, peginterferon alfa-2b, is indicated for use alone or in combination with REBETOL (ribavirin, USP) for the treatment of chronic hepatitis C in patients with compensated liver disease who have not been previously treated with interferon alpha and are at least 18 years of age. REBETOL (ribavirin, USP) Capsules and Oral Solution are indicated in combination with INTRON A (interferon alfa-2b, recombinant) Injection for the treatment of chronic hepatitis C in patients 18 years of age and older with compensated liver disease previously untreated with alpha interferon and in patients 18 years of age and older who have relapsed following alpha interferon therapy. Hepatitis C: * Chronic infection: 55%-85% of infected persons * Chronic liver disease: 70% of chronically infected persons * Deaths from chronic liver disease: 1%-5% of infected persons may die * Leading indication for liver transplant Answered by Tomoko Difrancisco 3 months ago.

Chemotherapy is the use of chemical substances to treat disease. PEG-Intron + Rebetol is an FDA approved combination therapies for Hepatits C Virus (HCV). So, YES it is a form of chemotherapy . I understand the confusion in your mind. I am sure it is because in the modern-day use of the term "chemotherapy", it refers primarily to cytotoxic drugs used to treat cancer. In the real sense however, chemotherapy is suppose to mean any usage of chemical substances to treat disease. For example: using antibiotics is a form of chemotherapy in the real essence of the term. To clarify: PEG-Intron + Rebetol are forms of chemotherapy but not for cancer. It is a treatment for HCV. Answered by Elke Howorth 3 months ago.


Is pegintron and uniferon the same? please explain..thanks?
Asked by Joyce Osterfeld 3 months ago.

No, pegintron is the brand name for pegylated interferon alpha 2b, and uniferon is an albumin-free interferon alpha 2b. The big difference is the peg products (there is also a similar product called Pegasys) are fat-encapsulated which gives the interferon a longer half life. That means that instead of needing 3 shots a week, you'll only have to have one a week. Even more important, while the half life of the pegylated interferons are longer, they do a much better job of suppressing the virus than the uniferon, thus giving the patient a higher chance of clearing the virus. Getz Pharma makes Uniferon and markets pharmaceutical products in Pakistan, Sri Lanka, Vietnam, Thailand, Malaysia, Philippines, Cambodia, Laos, Kenya, Uzebekistan, Kazakhstan and the Kyrghyz Republic. In the US, the non-pegylated interferon is not the standard of treatment anymore, as it's response rates are lower. If you have a choice between the two medications, don't bother with the uniferon and do the pegylated interferon; the results are better and the side effects are less. Personally, I have found the people in our support group tend to do better on the Pegasys brand of pegylated interferon (better response rate and less side effects) than the Pegintron. Pegasys is made by Roche Pharmaceuticals (Hoffman-LaRoche) and PegIntron is made by Schering-Plough. Hope this helps. Best wishes. Answered by Luther Waldal 3 months ago.

Yes basically they are the same. They niether have a decent track record for producing a sustained cure, and both have horrible side effects. I do believe there are better and safer modes of treatment. Seek out and learn as much as possible about all treatment modalities first. Be sure to have viral load before starting treatment and after treatment. 6 months after treatment. GOOD LUCK!!! Answered by Daria Minjarez 3 months ago.

What are you talking about. :-( Answered by Dannie Claybourn 3 months ago.


Any one have good stories about pegintron-ribivirin treatments for hepatitis C?
i want to know other peoples progress and to know if they were cured or did it come back? Asked by Ike Padget 3 months ago.

If you click on my name it takes you to my 360..read from the last page..I blogged treatment. I did the medicine and can say while it wasn't a walk in the park it was worth it. I cleared the virus in '05 and am now sitting with a 2yr undetectable viral load oh...cured? how about SVR= Sustanied Viral Responder that's me! Its gone The 'success rate' for genotypes 2&3 is 85% Genotypes 1a,1b are 50% Genotype 4 I'm not cetain..but I do know its a hard one to clear..tell your husband chin ^ Answered by Temeka Boatman 3 months ago.

I'm glad you asked this question, it's hard to find positive stories on the Internet. I did the treatment in 2004, used the Pegasys product, generic Ribivirin and a ton of herbal products - I had 1b (48 week treatment). It was a long treatment time, but I had minimal side effects. I have been clear since the midpoint of treatment. So cured...yes, they call it SVR as the other person who answered said. I'm writing a book about it, would you be interested in a free copy once it's finished? It would be great if I could get some outside reviews. Answered by Sarita Clinger 3 months ago.


Is lethicin helpful in treating hepatitis c?
prior treatment pegintron and ribavarin Asked by Doreatha Bulow 3 months ago.

if lethicin was a cure for hcv or helped in anyway, you'd be cured by now! Lethicin is found in many foods. Don't fall for "too good to be true" scams. Your money will literally go down the toilet...before you know it, your wasted money would pay for antiviral chemo. HCV is not something to play around with. Do not do anything your doctor advises against. Even good naturopathic doctors (which really aren't doctors) Know that HCV is only helped by antiviral chemotherapy. Answered by Kizzy Mercer 3 months ago.

I would think that the goal of any medication used to treat you would be to prevent cirrhosis and liver cancer from forming since that can be the end result of untreated hep C if it progresses to being cirrhosis. Why would anyone offer a medication that is going to cause cancer since liver cancer is often times fatal. The goal is to save and prolong your life, not cause more problems. You should get this clarified before you agree to anything and do some research on what they want to put in your body and its side effects. Do your homework, and don't take anything that is going to cause cancer. Answered by Eve Swire 3 months ago.

NO! OMG, dont fall for that "quack" crap. Just do what the doctor orders--no booze, no pills, just the weekly injections and the daily ribavirin pills. omg...*smacking my head over and over again* Answered by Bailey Froats 3 months ago.

If you have hep C then you need to see a doctor for correct treatment and control so that you dont pass it on to any one else. Answered by Dulce Trigueiro 3 months ago.


Is anyone dx with hep c?
is anyone on pegintron and how are you doing on it ,I just got on and I am not doing to good ,cant eat or sleep ,just want to know of others that are on it . Asked by Francene Uzzo 3 months ago.

Hi hon! I just wanted to tell you that pegintron affects everyone differently. Some people have no side effects at all while others have them horribly. I've been on the treatment twice. Once in 8th grade and I was on it again back in March. When I was in 8th grade, I had no side effects at all. All I had was a little redness around the injection sites. But when I took the treatment back in March, I thought I was going to die. Within a month, I had lost 20 lbs because I couldn't eat a thing. At night when I went to bed, I had to have 3 comforters on me because the chills were so bad. I was so weak I would almost pass out while trying to brush my teeth. By the last of April, the docs took me off the meds because I ended up at the ER with all the symptoms of a stroke. It's a long hard road and I hope you can get through it. The treatment hasn't worked for me yet and I have to wait until something new comes on the market with less side effects. But don't give up hope because when my mom took the treatment 8 years ago, she cleared the virus! She got Hep C from a blood transfusion in the 1960's. She has been Hep C free for 8 years now! I got it from my mom when I was born, and I still have hope that one of the newer treatments will clear the virus for me too! Good luck hon! If you need someone to talk to, you can email me. Answered by Jacob Gibb 3 months ago.

Drink lots of water, it will help decrease any nausea you might have. Eat small meals, get some exercise, even if it's just walking a little. Your doctor can prescribe a sleep aid like ambien or something if you are having insomnia. Join a support group and educate yourself about little tricks to keep the side effects at bay. My support group friends helped me so much; they knew exactly what I was going through and their input helped me to learn a lot. I've been clear of the virus for over 7 years. Best wishes to you & remember, attitude is 90% of the battle, so keep a positive attitude and defeat the dragon! Best wishes. Answered by Carlita Schrag 3 months ago.

I dont have hep c or on any meds for it. I am just sorry you are having a hard time. a matter of fact I was just dx with ms. well hang in there! Answered by Marisol Plowden 3 months ago.

I was on peg interferon and ribavirin for 11 months, five years ago. I have been virus free since. What got me through is rest, try to keep busy/moving, drink at least 8 glasses of water, no alcoholic beverages, and I took up Yoga. High impact exercises like running and biking will cause me to get severe headaches and dehydration. You may need to keep a journal on how you feel, what you ate and drink, daily activities, etc. You need to keep getting your blood check since ribavirin lowers your red blood count. Answered by Shanon Loerwald 3 months ago.


Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
103949/001 PEGINTRON PEGINTERFERON ALFA-2B /VIAL 50UG per 0.5ML
103949/002 PEGINTRON PEGINTERFERON ALFA-2B /VIAL 80UG per 0.5ML
103949/003 PEGINTRON PEGINTERFERON ALFA-2B /VIAL 120UG per 0.5ML
103949/004 PEGINTRON PEGINTERFERON ALFA-2B /VIAL 150UG per 0.5ML
103949/005 PEGINTRON PEGINTERFERON ALFA-2B /SYRINGE 50UG per 0.5ML
103949/006 PEGINTRON PEGINTERFERON ALFA-2B /SYRINGE 80UG per 0.5ML
103949/007 PEGINTRON PEGINTERFERON ALFA-2B /SYRINGE 150UG per 0.5ML
103949/008 PEGINTRON PEGINTERFERON ALFA-2B /SYRINGE 120UG per 0.5ML

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
103949/001 PEGINTRON PEGINTERFERON ALFA-2B /VIAL 50UG per 0.5ML
103949/002 PEGINTRON PEGINTERFERON ALFA-2B /VIAL 80UG per 0.5ML
103949/003 PEGINTRON PEGINTERFERON ALFA-2B /VIAL 120UG per 0.5ML
103949/004 PEGINTRON PEGINTERFERON ALFA-2B /VIAL 150UG per 0.5ML
103949/005 PEGINTRON PEGINTERFERON ALFA-2B /SYRINGE 50UG per 0.5ML
103949/006 PEGINTRON PEGINTERFERON ALFA-2B /SYRINGE 80UG per 0.5ML
103949/007 PEGINTRON PEGINTERFERON ALFA-2B /SYRINGE 150UG per 0.5ML
103949/008 PEGINTRON PEGINTERFERON ALFA-2B /SYRINGE 120UG per 0.5ML
103949/009 SYLATRON PEGINTERFERON ALFA-2B /VIAL 296 MCG LYOPHILIZED POWDER PER SINGLE-USE VIAL
103949/010 SYLATRON PEGINTERFERON ALFA-2B /VIAL 444 MCG LYOPHILIZED POWDER PER SINGLE-USE VIAL
103949/011 SYLATRON PEGINTERFERON ALFA-2B /VIAL 888 MCG LYOPHILIZED POWDER PER SINGLE-USE VIAL

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