Application Information

This drug has been submitted to the FDA under the reference 012342/003.

Names and composition

"PARNATE" is the commercial name of a drug composed of TRANYLCYPROMINE SULFATE.

Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
012342/003 PARNATE TRANYLCYPROMINE SULFATE TABLET/ORAL EQ 10MG BASE

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
012342/003 PARNATE TRANYLCYPROMINE SULFATE TABLET/ORAL EQ 10MG BASE
040640/001 TRANYLCYPROMINE SULFATE TRANYLCYPROMINE SULFATE TABLET/ORAL EQ 10MG BASE

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Answered questions

I have a lot of questions about parnate?
is it possible that the effects of parnate could be mildly felt within the first few doses? i only started it 3 days ago, and it seems like things don't get me all emotional as they normally do. is this in my head or am i really seeing the parnate working like it should. also, i've read that parnate can... Asked by Jaunita Dokken 1 year ago.

is it possible that the effects of parnate could be mildly felt within the first few doses? i only started it 3 days ago, and it seems like things don't get me all emotional as they normally do. is this in my head or am i really seeing the parnate working like it should. also, i've read that parnate can cause mania in ppl who have bipolar, i don't know yet what my diagnosis is, so how could i tell if i become manic? Answered by Jospeh Kluge 1 year ago.

Parnate (tranylcypromine) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. Stop using tranylcypromine and call your doctor at once if you have any of these serious side effects: frequent headaches, vision problems, sensitivity to light; fast or pounding heart beats, tight feeling in your chest or throat; swelling of your ankles or feet; pale skin, easy bruising or bleeding, unusual weakness; nausea, vomiting, dizziness, sweating, stiffness in your neck; confusion, lack of coordination, feeling light-headed, fainting; or tremors, muscle twitches you cannot control. Less serious side effects may include: feeling restless, weak, or drowsy; nausea, diarrhea or constipation, loss of appetite, stomach pain; chills, numbness or tingly feeling; dry mouth, decreased urination; blurred vision, ringing in your ears; or impotence, difficulty having an orgasm. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. What other drugs will affect Parnate (tranylcypromine)? There are many other medicines that can cause serious medical problems if you take them together with tranylcypromine. Do not take tranylcypromine before telling your doctor about all other prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor, dentist, or other healthcare provider who treats you. Answered by Janey Hickonbottom 1 year ago.

People confuse mood with emotion..... mood affects everything about you. Your energy level, sleep patterns, appetite, emotional response (which emotions you feel and how strongly), your judgment, sexual appetite, etc....... Bipolar is not about being happy one minute then sad the next then mad, that is just having emotions..... The mood swings in Bipolar last a very long time, weeks to months to years and the average Bipolar only swings once or twice a year. People never never understand the true severity of bipolar disorder. They also do not understand that for an "episode" to be considered Bipolar it has to last all day every day for a week....... That's the minimum, in reality the episodes last for weeks or months or even years. There are cases where a person can have more than one or two episodes a year but it is really rare. Also you HAVE TO HAVE the mania (or hypomania) for it to be bipolar. Without mania it is just recurring depression. The mood swings in Bipolar do not usually have a trigger. They come and go very randomly...... If someone with Bipolar is depressed or manic there is nothing you can do to bring them out of their mood short of medication..... This is what Bipolar is like for me. Depression- to tired to get out of bed, shower, brush your teeth..... lie in bed and stare at the ceiling for days at a time, crying a lot, feelings of guilt, and self loathing, may be suicidal but are too tired to even consider planning it, sleep 16 hours a day or more, eating too much or not enough. Manic - over the moon happy, hypersexual (like masturbating 10 times a day or sleeping with numerous men, strangers, your cousin.......decide you are bi because then there are twice as many people to have sex with, decide you are into BDSM and contract to be someones slave for a week), spending your mortgage money on african violets (or some other useless things), driving your car 120 mph, grandiose thoughts (like thinking you can put a new furnace in your house by yourself, or tearing the sideing of the house because youcan put ip new stuff by yourself with a hammer and a hacksaw), quitting your job because you are buying lottery tickets with your last paycheck and you know you will win...... only sleep 2 or 3 hours a night and feel completely rested, can't concentrate, racing thoughts (it sounds like 50 people in your head all talking at the same time), talk really fast and loud because your mouth can't keep up with our mind. Answered by Giselle Lasselle 1 year ago.

hey, sorry to hear your friend is unwell. yes, those are symptoms of panic attacks but nearly also all of them are symptoms of an eating disorder. how ever you have not mentioned anything anout her eating so im not sure. best way is to go to a doctor. good luck xx Answered by Natosha Heckard 1 year ago.


Can you take xanax for anxiety if you are on parnate?
Asked by Lou Crouter 1 year ago.

If you can't ask your dr....ask a pharmacist. They usually will help if they're not too busy. Remember what happened to Anna Nicole...and to so many other people. Be really careful about mixing medicines....and always tell your dr. every thing you are taking...even if it's aspirin. I take a half mg. of Risperdol for anxiety. I know other people it's helped with anxiety and panic attacks....you might want to ask your dr. about it. I don't know what parnate is. I'm gonna look it up. I need all the information I can get. I don't like to be uninformed about medicines....and their side effects. If something doesn't make me feel right...I don't take it. I have a good dr. who works with me on this till we get it right. Xanax didn't work for me...but it might work for you. Good Luck.PS. I googled parnate...you should too...it says you have to be careful what you even eat when taking it...that it could hurt you if you mixed it with even the wrong food. You need to find out all you can about it..especially before you mix another drug with it. ASK YOUR DR (Read below from Google) .Never take Parnate with the following drugs; the combination can trigger seizures or a dangerous spike in blood pressure: Other MAO inhibitors such as Nardil Antidepressant drugs classified as tricyclics, such as Anafranil, Elavil, and Tofranil Carbamazepine (Tegretol) Cyclobenzaprine (Flexeril) When switching from one of these drugs to Parnate, or vice versa, allow an interval of at least 1 week between medications. Also avoid combining Parnate with any of the following: Antidepressant drugs classified as selective serotonin reuptake inhibitors, such as Paxil, Prozac, and Zoloft Amphetamines such as Adderall and Dexedrine Anesthetics Antihistamines such as Allegra, Benadryl, and Clarinex Blood pressure medications such as Accupril, Lotensin, and Prinivil Bupropion (Wellbutrin) Buspirone (BuSpar) Cold and hay fever remedies that constrict blood vessels Cough remedies containing dextromethorphan Demerol and other narcotic painkillers such as Percodan, OxyContin, and Vicodin Disulfiram (Antabuse) Guanethidine Methyldopa Over-the-counter weight reduction aids Parkinson's disease medications such as Parlodel, Requip, and Sinemet Reserpine Sedatives such as Halcion, Nembutal, and Seconal Tryptophan Water pills such as HydroDIURIL While taking Parnate, you should also avoid foods that contain a high amount of a substance called tyramine, including: Anchovies Avocados Bananas Beer (including nonalcoholic beer) Caviar Cheese (especially strong and aged varieties) Chianti wine Chocolate Dried fruits (including raisins, prunes, and figs) Liqueurs Liver Meat extracts or meat prepared with tenderizers Overripe fruit Pickled herring Pods of broad beans like fava beans Raspberries Sauerkraut Sherry Sour cream Soy sauce Yeast extracts Yogurt Likewise, avoid alcohol and large amounts of caffeine. SORRY THIS IS SO LONG...WANTED YOU TO HAVE THIS INFORMATION. Answered by Lajuana Stasinos 1 year ago.

I don't know what parnate is, but your doctor can look up on the computer to find out if it's okay to mix. I take several antidepressants and whenever I get a new medication, my doctor looks it up first and gives me a printout of any possible side effects. Good Luck! Xanax is great!! Answered by Ramon Millier 1 year ago.


Is Parnate weight neutral?
I've gained too much weight on the SSRIs, and they don't work that well, hence we are trying parnate. Is it weight neutral, or does it cause weight gain/loss? I jsut want to be at my normal weight! Any personal experiences and knowledge would be great Asked by Racheal Lobstein 1 year ago.

I've never taken Parnate, but I'm sure I read that it doesn't cause weight gain, because it's one of the more stimulating anti depressants. For more info, you can google it; or get hold of 'Feeling Good' by Dr David Burns; you need the revised, updated version. The last section of the book is all about anti depressants and he does discuss the MAOIs. I'm guessing you already know that on this drug there are several foods you'll have to avoid, as well as many medicines, including some over the counter ones. Good luck. Answered by Juli Killough 1 year ago.

fresh herbs can really zing up a healthy meal try growing some in the kitchen using a strawberry pot preserve the flavor by adding fresh herbs at the end of the cooking process Answered by Elene Finch 1 year ago.

chew gum while cooking to stop snacking Answered by Eldridge Roehrick 1 year ago.

walk around your home yard or neighborhood while on the phone Answered by Soon Connoly 1 year ago.


Question about MAOi Parnate?
Parnate is a very good medication when it works, but there have been two times where I have seen it stop working, what would be the reason for this Asked by Caridad Ouye 1 year ago.

I don't know specifically about Parnate, but I do know that I have had an antidepressant simply stop working for me. My psychiatrist said that it just happens sometimes, and often enough that they call it "poop-out syndrome." My personal thought is that, like any psychoactive drug, a brain can just adapt to the drug, so it stops working. Answered by Peter Dourado 1 year ago.


Has anyone ever used parnate? is it effective?
I've read on http://www.drugdelivery.ca/s3929-s-PARNATE.aspx a lot about parnate but i haven't found anything about it's effectiveness... i've been on lexapro, xanax before and some more but nothing worked for me. i'm severely depressed! Asked by Phung Mammano 1 year ago.

Since you have not responded to any other medications, this is why you are now on Parnate. Parnate is a MonoAmine Oxidase Inhibitor (MAOI). Monoamine Oxidase is an enzyme that breaks down neurotransmitters in the synaptic cleft (mainly serotonin) so the substance can be recycled. This allows for more interaction between the neurotransmitter and the neuron to be stimulated. As this happens throughout the entire central nervous system, mood is elevated and you are more alert. However, unlike with the other treatments that you have tried, you are going to have to make some SERIOUS changes to your diet. Aged foods containing Tyramine will cause your blood pressure to skyrocket (this can lead to a stroke). Foods like: Aged cheeses, chocolate, wines and so on. You ought to consider ECT if your depression is not improving. Answered by Ela Cutten 1 year ago.

I have a cat and a Min Pin dog (bred to rid the home of varmints) so no mice stay in my home over an hour and I live in a grain producing part of the country. It's tricky to keep them out. You can use mouse traps, but place them near the wall and behind the refrigerator or other appliances and under the sink in the kitchen. Caulk all holes, especially those around pipes coming up into the house from outdoors or basement. Mice can squeeze through the smallest hole. Quit feeding them-you have to be meticulous to the max-no crumbs anywhere-put all cereals, etc., on the highest shelf with no way for them to gain entrance. Ugh-I wish you luck-you can do this! Answered by Chantelle Wetz 1 year ago.


A few questions about the MAOI anti-depressant Parnate (Tranylcypromine)?
I guess this mainly goes out to the health-care professionals, but I'm also interested in individuals' experiences taking this medication. I know this may differ greatly depending on the patient, but what is the average length of time people usually stay on the MAOI anti-depressant medication Parnate ? (assuming... Asked by Marcene Kaspar 1 year ago.

I guess this mainly goes out to the health-care professionals, but I'm also interested in individuals' experiences taking this medication. I know this may differ greatly depending on the patient, but what is the average length of time people usually stay on the MAOI anti-depressant medication Parnate ? (assuming that its having a positive effect). I ask because I've heard anecdotal reports from people that its the kind of anti-depressant that one stays on for a long time (6 months? years?). I've also heard that it can be common for the depression to return after you stop taking it (i know this can happen with all anti-depressants, but I've heard it is especially true with Parnate)...any validity to these claims? Thanks for your time! Answered by Dave Aristizabal 1 year ago.

It's an antidepressant you stay on long term in the sense that the people who end up on it don't have your average, easily treatable depression. MAOIs come out of the medicine cabinet for the hard stuff, the world-ending, totally disabling, totally intractable depressions. And they work like nothing else on the planet. There's MAOI formulations out there that have better success rates than brain implants and electroconvulsive therapy As a general statement, a little less than half the people who get depression have it recurrently, and that's independent of the treatment. There's a bit of sampling bias with MAOIs, as the depression recurs, but you're only giving it to people with the really bad cases where they have essentially chronic depression. It's not a function of the drug. Standard length of treatment for antidepressants is twelve months. However, MAOIs are not used standard, and they're generally used for years or even decades once a person is stable on them. Answered by Aleshia Frankl 1 year ago.

What you have to realize when they say there is an increased risk of suicide is that the people who take anti depressants in the first place are depressed, and can't handle the pressures of life, and most commonly don't want to live in a life of misery. Those types of people are the most common group of people who take their lives, whether they are on pills or not. Effexor has a few side effects that are pretty common. Dry mouth and excessive sweating are pretty common. So is a dulling in their zest for life. Sexual side effects are also not uncommon. Answered by Bernita Mautner 1 year ago.


Nardil or Parnate experience?
Has anyone had any experience with Nardil or Parnate. I suffer from Social Anxiety and mild depression. What did you use it to treat, what was your experience, did it help you?. and i know that there is a diet for it, did you follow the diet? Asked by Sade Boldery 1 year ago.

Nardil is probably the best drug out there for social anxiety. Don't let people scare you by saying it's an old drug that nobody uses anymore. It is an old drug but a good one that works on every neurotransmitter rather than just dopamine or serotonin. There is a diet to follow but it's not as bad as they used to make it seem - you just can't eat aged foods such as aged cheeses (pizza is okay), aged meats (anything than doesn't require refrigeration - sausages, country ham, etc) and keg beers and some wines. Bottled beer is okay - it's the bacteria in the kegs. Side effects can vary a lot. Some people just find it to be a miracle drug with no side effects. Others find a lot such as weight gain, sleepiness, urinary hesitancy, etc. I am one that had a lot of side effects but found it to be quite successful for social anxiety. I'm disappointed it wasn't a miracle for me like it is for 80% of people but the weight gain was too much. Check out askapatient.com and revolution health for reviews. Hope that helps. I'm getting ready to try Parnate because it's more activating and doesn't cause as much of the tiredness but it supposedly doesn't work as well on anxiety so we will see. Answered by Lenna Delapenha 1 year ago.

can be tried as a last resort, I think you should carry a med to counter the cheese effect, an alpha blocker, I think the diet is strict Answered by Zona Whtie 1 year ago.


Can Topamax and Parnate be taken together?
Is this generally not a combo that is used together? Asked by Renay Leader 1 year ago.

Other than certain foods and drinks interacting with Parnate, I do not see any reported side effects listed if these two medications are taken together. This is something you need to discuss with your doctor, to make sure that it is ok with him/her that you do so. If your doctor approves and you do experience any side effects, you will need to mention this to your doctor immediately. Answered by Son Gunzenhauser 1 year ago.


Experiences with Parnate?
Going to start Parnate at the end of July, and just wanting to hear of some personal experiences with the medication.. side-effects and such. I've read all the cookie-cutter BS that is put out there by the docs and drug companies. I'd rather hear personal experiences from people who actually used it for... Asked by Sal Delmoral 1 year ago.

Going to start Parnate at the end of July, and just wanting to hear of some personal experiences with the medication.. side-effects and such. I've read all the cookie-cutter BS that is put out there by the docs and drug companies. I'd rather hear personal experiences from people who actually used it for depression/anxiety. Answered by Enedina Epperly 1 year ago.

I've never taken this medication but I've heard that's it's rather wonderful! It's meant to be one of the most 'enjoyable' anti depressants as it is stimulating and can produce really significant elevation of mood. It's also been around for a long time. I'm guessing you know that as it's an MAOI there are several foods and many medications, including some over the counter ones, that you will have to avoid, as with these drugs there can be dangerous interactions. Good luck with it. I decided a while back that I might ask my doctor about this drug if my current anti depressant doesn't improve. Answered by Zina Kranock 1 year ago.

This is one of the many drugs I have taken over several years. If I am not mistaken, one of the things my doctor told me was not to drink RED WINE with it. This is an MAO inhibitor and you have to be really careful what you take with it....over the counter meds and certain foods, as stated in one of the answers. and DO NOT DRINK ALCOHOL!!! Answered by Chi Lanctot 1 year ago.

How about the FDA? Answered by Madelyn Mclaird 1 year ago.


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