NARDIL Ressources

Application Information

This drug has been submitted to the FDA under the reference 011909/002.

Names and composition

"NARDIL" is the commercial name of a drug composed of PHENELZINE SULFATE.
It belongs to the class Monoamine oxidase inhibitors and is used in Depression (Central Nervous System)

Answered questions

Why does Nardil help me and other antidepressants don't?
What is different about Nardil, I have always had cold hands, fast heart rate, nervousness, I started taking Nardil and these conditions resolved in about 2-3 weeks, other antidepressants I've taken didn't do that. Asked by Darcel Tanous 3 months ago.

Nardil is an MAO Inhibitor type of anti-depressant that is infrequently used these days because of the serious dietary restrictions and potential other interactions with many medications. It effects serotonin, norepinephrine and dopamine and that alone makes it different from any other class of typically used anti-depressants and makes it a "broader spectrum" treatment as most anti-depressants affect either serotonin (SSRI's) or Norepinephrine (SNRI-Wellbutrin) or a combination of the two (SNRI's like Cymbalta and Effexor). I have never yet had a client on an MAOI and I would be really interested in hearing your reactions in more detail and what your initial symptoms were. I'd also be really interested to hear how you've coped with the multiple dietary restrictions and how long you've been on Nardil as well as what other meds you had tried previously. Just as a point of history, the MAOI's were the first anti-depressants ever used and I believe they were originally developed to treat tuberculosis until they discovered they had significant impact on the depression associated with the disease. Answered by Guy Erdelt 3 months ago.

everybodys body works differently so you may not get any effect out of the other ones but that's not a bad thing as long as you can take the Nardil, I guess... Answered by Belle Bodden 3 months ago.

molly, everybody's body is different what really matters is that something worked Answered by Shirely Ronzoni 3 months ago.


Nardil or Parnate experience?
Has anyone had any experience with Nardil or Parnate. I suffer from Social Anxiety and mild depression. What did you use it to treat, what was your experience, did it help you?. and i know that there is a diet for it, did you follow the diet? Asked by Lon Ducey 3 months ago.

Nardil is probably the best drug out there for social anxiety. Don't let people scare you by saying it's an old drug that nobody uses anymore. It is an old drug but a good one that works on every neurotransmitter rather than just dopamine or serotonin. There is a diet to follow but it's not as bad as they used to make it seem - you just can't eat aged foods such as aged cheeses (pizza is okay), aged meats (anything than doesn't require refrigeration - sausages, country ham, etc) and keg beers and some wines. Bottled beer is okay - it's the bacteria in the kegs. Side effects can vary a lot. Some people just find it to be a miracle drug with no side effects. Others find a lot such as weight gain, sleepiness, urinary hesitancy, etc. I am one that had a lot of side effects but found it to be quite successful for social anxiety. I'm disappointed it wasn't a miracle for me like it is for 80% of people but the weight gain was too much. Check out askapatient.com and revolution health for reviews. Hope that helps. I'm getting ready to try Parnate because it's more activating and doesn't cause as much of the tiredness but it supposedly doesn't work as well on anxiety so we will see. Answered by Dan Dorr 3 months ago.

can be tried as a last resort, I think you should carry a med to counter the cheese effect, an alpha blocker, I think the diet is strict Answered by Lucie Buffington 3 months ago.


What is the danger of drinking beer (or alcholol) with Nardil.?
Also, is it dangerous to drink in moderation while on Nardil? Asked by Elva Merrills 3 months ago.

Most important fact about Nardil Avoid the following foods, beverages, and medications while taking Nardil and for 2 weeks after stopping it: Beer (including alcohol-free or reduced-alcohol beer) Caffeine (in excessive amounts) Cheese (except for cottage cheese and cream cheese) Chocolate (in excessive amounts) Dry sausage (including Genoa salami, hard salami, pepperoni, and Lebanon bologna) Fava bean pods Liver Meat extract Pickled herring Pickled, fermented, aged, or smoked meat, fish, or dairy products Sauerkraut Spoiled or improperly stored meat, fish, or dairy products Wine (including alcohol-free or reduced-alcohol wine) Yeast extract (including large amounts of brewer's yeast) Yogurt Medications to avoid: Amphetamines Appetite suppressants such as Redux and Tenuate Antidepressants and related medications such as Celexa, Effexor, fluvoxamine, Paxil, Prozac, Remeron, Serzone, Wellbutrin, Zoloft, Elavil, Triavil, Tegretol, and Flexeril Asthma inhalants such as Proventil and Ventolin Cold and cough preparations including those with dextromethorphan, such as Robitussin DM Hay fever medications such as Contac and Dristan L-tryptophan-containing products Nasal decongestants in tablet, drop, or spray form such as Sudafed Sinus medications such as Sinutab Stimulants such as Ritalin and epinephrine (EpiPen) Taking Nardil with any of the above foods, beverages, or medications can cause serious, potentially fatal, high blood pressure. Therefore, when taking Nardil you should immediately report the occurrence of a headache, heart palpitations, or any other unusual symptom. In addition, make certain that you inform any other physician or dentist you see that you are currently taking Nardil or have taken Nardil within the last 2 weeks. Answered by Addie Bacchi 3 months ago.

I've been on Nardil for 19 years. I can drink beer and a lot of it. I also drink a lot of coofee every day when it's said you don't do that. I think one build up a tollerence to things and the body compensates. you can drink liquor and fortified wine. don't try real aged wine. I drink rum. There is no danger with alcohol, just aged or junk like wine where the aging has altered the composition. traditionally, one should avoid fermented stuff. Liquors and mixed drinks are alright. I know. Answered by Mana Gibbs 3 months ago.

ARE YOU NUTS? Nardil and alcohol do not mix. Read the label. Yes, its dangerous to drink with many drugs, especially ones that work on the central nervous system. Answered by Cherri Doeberling 3 months ago.


Important questions about an antidepressant (Nardil) for social anxiety...?
Hello my name is jesse and i am a 16 year old that has had Generalized Anxiety Disorder and Severe Social Anxiety Disorder for the past 3 years. I have tried many many many medications such as; Paxil, Prozac, Zoloft, Lexapro, Citalopram, Effexor, Buspar, Pristiq and lorazapam but non have worked in the slightest... Asked by Librada Carnagey 3 months ago.

Hello my name is jesse and i am a 16 year old that has had Generalized Anxiety Disorder and Severe Social Anxiety Disorder for the past 3 years. I have tried many many many medications such as; Paxil, Prozac, Zoloft, Lexapro, Citalopram, Effexor, Buspar, Pristiq and lorazapam but non have worked in the slightest bit even while giving them enough time to reach their fullest pottential. Im even seeing a cognitive behavioral therapist and even though hes taught me to realize how irrational the fears i still cant shake this especially in my high school during the day (especially with the fight or flight response going throughout me all day which leads to fatigue). I was just wondering what your experience was on this type of medication, would a dr be hesitant on using it on a 16 yr old adolescent like myself and finally how long it would take to see results on it. BTW my nutrition is 10/10 and i exercise 5 days a week to release endorphins. Sorry this was soo long and thank you for any response:) Answered by Willena Pedez 3 months ago.

Nardil is an MAO Inhibitor. I took MAO Inhibitors for over 20 years. MAO Inhibitors are an older class of drugs and can be effective if the person's "problem" is epinephrine (norepinephrine, noradrenaline) rather than serotonin or dopamine. MAO Inhibitors stop monoamine oxidase (MAO) from working. MAO is the enzyme that causes your body to excrete (or not use) epinephrine. One very, very big drawback to MAO Inhibitors is you will have many food/drug interactions. You cannot eat foods containing tyramine. This includes aged foods such as sour cream and cheese. It also includes odd foods such as bananas. You can also NOT take many types of cold medicines. There can be a hypertensive crisis (very high blood pressure) if you have a food/drug interaction. MAO Inhibitors themselves can cause postural hypotension (orthostatic hypotension). This happens when you stand up too quickly and your blood pressure drops. You simply have to learn to stand up and get up more slowly. In my experience, MAO Inhibitors work very well and very quickly. I felt better within a week of starting them. The better mood and energy was wonderful to experience. Many doctors don't prescribe MAO inhibitors when serotonin and dopamine reuptake inhibitors have fewer adverse effects. If you do take MAO inhibitors, you will need to educate yourself and watch closely what foods and drugs you ingest. Answered by Palmira Mabie 3 months ago.

Nardil Social Anxiety Answered by Stacee Roemen 3 months ago.

Nardil (phenelzine) is used for patients with treatment resistant major depression. It has been useful for social anxiety disorder and panic disorder in some patients as it does have anxiolytic (anti-anxiety) properties along with antidepressant action. There are many serious adverse effects with the MAOIs. At only 16 years old, if you wish to have children in the future, or dental work, or surgery, don't use Nardil. Some of the side effects are irreversible, and dangerous - like muscle tremors and sexual paralysis/numbing. You won't be able to eat aged or processed cheese or meats, most dairy, turkey, liver, alcohol, fermented substances (wine), meat extracts, yeast extracts, broad beans, St. John's Wort, coffee, tobacco, red grapes, ginko biloba, tea, cocoa, kava, olive oil, pepper, liquorice, nutmeg, arsley, dill, and a whole list of other foods. MAOIs are lethal when combined with SSRIs, tricyclics, MDMA, merperidine, tramadol, demerol and dextromethorphan (found in most cough and cold preparations). MAOIs like most antidepressants are addictive and have a withdrawal syndrome of weeks to months and some side effects last a year or longer, some are irreversible. You won't be able to get off an MAOI and get right on another type of antidepressant-your anxiety can rebound and feel far worse than before treatment.. Your doctor will not want to put you on an MAOI. There is a reversible MAO-A called Moclobemide Answered by Tomasa Weida 3 months ago.

my sister was on an antidepressant. she couldn't get off it. she was addicted. the withdrawal made her go insane. she is not the same person she was and never will be. don't take antidepressant Answered by Iva Manasares 3 months ago.


Have taken nardil for almost 9 years.the formula has been changed. Myself and thousands more need this medicat
This medication is used to treat a serious major atypical depressive disorder. Pfizer made a new formula that does not have the same effectiveness as the original formula had. I have done a lot of research and I do know that this isn't going to be easy but it is NOT impossible. What needs to happen, is that... Asked by Denny Vallieres 3 months ago.

This medication is used to treat a serious major atypical depressive disorder. Pfizer made a new formula that does not have the same effectiveness as the original formula had. I have done a lot of research and I do know that this isn't going to be easy but it is NOT impossible. What needs to happen, is that our mental health professionals need to pool together and have this medcation made back in it's original formula. This so desperately needs attetion. Mental health is just as important and can be just as Fatel as cancer,heart disease, diabetes, etc,.. If there's anyone out there or if you know someone with any information to help me,please post!!!!!!!! Answered by Mavis Casewell 3 months ago.

You know that the reason they take drugs off is because it did some bad stuff on the long term , I don't know what but bad enough to get it off the market before we found out , because you know us , we sue , sue ,sue, and so to avoid it ,you close up shop and run ,, it's eather that or loose every dime you ever made and then some , blame the sue machine , it works too well ,,, Answered by Kimberlie Ruland 3 months ago.


Is it worth asking my doctor about switching to Nardil?
I currently take desvenlafaxine (Pristiq) and still have issues with it regarding anxiety and also suicidal ideation. For the record, I do know that they are in different classes of medications (one's an SSRI and the other is an MAO inhibitor). I guess what I'm really asking is whether it's worth it to... Asked by Merrill Carchi 3 months ago.

I currently take desvenlafaxine (Pristiq) and still have issues with it regarding anxiety and also suicidal ideation. For the record, I do know that they are in different classes of medications (one's an SSRI and the other is an MAO inhibitor). I guess what I'm really asking is whether it's worth it to look into an MAO inhibitor. I apologize in advance if this seems like a dumb question. Thanks for any help you can give me, guys. Answered by Chan Delano 3 months ago.

Hello...Please consider other medications before Nardil.I know we are all different but I had a really bad experience with Nardil.I wish you the best of luck. Foods and Beverages to Avoid During Phenelzine Therapy Meat and Fish: Pickled herring, liver, dry sausage (including Genoa salami, hard salami, pepperoni, and Lebanon bologna) Vegetables: Broad bean pods (fava beans) Dairy Products: Cheese (cottage cheese and cream cheese are allowed), yogurt Beverages: Beer and wine, alcohol-free and reduced-alcohol beer and wine products Miscellaneous: Yeast extract (including brewer's yeast in large quantities), excessive amounts of chocolate or caffeine --------------------------------------... Patients being treated with phenelzine should also avoid any spoiled or improperly refrigerated, handled or stored protein-rich foods such as meats, fish and dairy products, inlcuding foods that may have undergone protein breakdown by aging, pickling, fermentation, or smoking to improve flavor. In depressed patients, the possibility of suicide should always be considered and adequate precautions taken. It is recommended that careful observation of patients undergoing phenelzine treatment should be maintained until control of depression is achieved. If necessary, additional measures (ECT, hospitalization, etc.) should be instituted. Your question was not dumb. Answered by Francie Crompton 3 months ago.

Ask for a photocopy of your chart. Then only hand furnish then. Faxing 10 years of artwork for a guy or woman who's wholesome is a large job. I worked for an workplace that would take the request and interior the month have a image reproduction waiting for the affected person to %. up (I worked for an inner drugs workplace). There may well be 2-3 hours a week that somebody might do them and however the pile never went down. So particular, it somewhat is criminal to cost for faxing and photocopying as a results of fact it it costing the workplace money. Answered by Louis Varisco 3 months ago.

If you are having adverse effects from any medication you should speak with your doctor. The side effects you are describing are severe and you should definitely say something. Your doctor/psychiatrist will be able to recommend another medication that will hopefully be more helpful for you. Never have any doubts about speaking to medical/psychological providers regarding these issues. This is their job and you are paying them to do it, asking questions will only help you. Answered by Malena Sequeira 3 months ago.

well, it's always worth talking to your doctor. One type may work better for you than another. But PLEASE don't hesitate to ask your doctor. I hope you get to feeling better and I know that your doctor would too. It might be worth asking your pharmacist about also. Answered by Ladawn Redman 3 months ago.


How do I wean off the new Nardil antidepressant?
I am taking 1 tablet of the new Nardil a day. I been on the new Nardil since 2003 but been on the old Nardil since 1986 but those days was on 2 a day. Now I am on one a day and how do you wean off of that? Is anyone here on new Nardil? Has anyone ever weaned off of it? Asked by Myrtie Meeker 3 months ago.

The new nardil, is a MAOI (Mono amine oxidase inhibitor) Which is a strong antidepressant, this comes with side effects including hypertension, decreased libido and Tachycardia/Proxycardia. There are other types of antidepressants including SSRI's SSNI's and beta blockers, all of which are less powerful but are used as substitutes for other stronger Antidepressants when trying to wean off them. Therefore if you speak to your doctor, they will explain how you can move onto a higher dosage, weaker antidepressant then slowly lower the dosage. They will reccommend how and what to and you can go from there. Hope this helped a little Matt Answered by Twana Pradhan 3 months ago.

I'VE BEEN TAKING NARDIL 15MG 3X A DAY FOR APPROX. 30 YEARS.... IT'S HORRIBLE !!! IT CAUSES SEVERE DRY MOUTH. THE DRY MOUTH CAUSED ALL MY TEETH TO BREAK OFF.... THIS MEDICATION SHOULD BE BANNED !!! ALSO, IT IS NOT A NEW MEDICATION--VERY OLD AND MODERN DRS. DON NOT LIKE TO PRESCRIBE IT !!!! Answered by Joelle Hantula 3 months ago.

Diffinitely the doctor is the one to help you to wean yourself off the drug. Answered by Adaline Tarbox 3 months ago.

I think the best idea would be to talk to your doctor about this. Answered by Stephan Buchinsky 3 months ago.

ask the dr who gave it to you Answered by Yuk Enix 3 months ago.


Can you eat food with soy sauce while on nardil?
Asked by Noella Glancy 3 months ago.

Nardil is an MAOI? so you have to be careful of tyrosine So I'd recommend avoiding anything containing soy sauce. Answered by Billie Creach 3 months ago.

Not recommended. Answered by Alysia Selfe 3 months ago.


Are Seroquel and Nardil contraindicated?
I am withdrawing off of Clonazepam. I researched "Medications that increase GABA production in the brain". GABA is a potent neurotransmitter that controls other neurotransmitters ie: serotonin and norepinephrine. I found that the drug Nardil which is a MAOI that is suppose to potentiate the production... Asked by Sheridan Faust 3 months ago.

I am withdrawing off of Clonazepam. I researched "Medications that increase GABA production in the brain". GABA is a potent neurotransmitter that controls other neurotransmitters ie: serotonin and norepinephrine. I found that the drug Nardil which is a MAOI that is suppose to potentiate the production of GABA which the clonazepam has muted. I have subsquently also been prescribed Seroquel to help with the clonazepam withdrawal syndrome. I am experiencing high blood pressure, headaches, food cravings that I cannot feed, as well as severe bouts of confusion. My research has only produced information that is above my clinical expertise. I am at a crux. Do I need to stop the Nardil, stop the seroquel, both or neither? I am scared! I don't believe that my doctor has any useful insight in this matter. HELP! Answered by Hedwig Ako 3 months ago.

Interactions between your selected drugs phenelzine ↔ quetiapine Applies to:Nardil (phenelzine) and Seroquel (quetiapine) MONITOR: Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients. MANAGEMENT: During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities. You are at moderate risk of a drug interaction: Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. Your headaches and high blood pressure qualify as CNS symptoms. None of us here should advise you on what to take and what to stop sorry, because all the medications you are taking are powerful drugs that alter the brain chemistry, and we are not your primary care physician. I know this doesn't help you much, so my only other suggestion is to find a different doctor that IS able to help you, or contact an addiction service, which will have specialists that may have answers for you. Answered by Lisbeth Wallner 3 months ago.

My wife is on the Clonazepam and Seroquel and Nardil which she's now been on for two weeks to replace Parnate which wasn't working that well. She has bipolar and struggles horribly with depression. I've noticed some difficulty in waking but as far as taking the meds together, as was mentioned, the psychiatrist is the best trained to answer that question. Answered by Toi Holak 3 months ago.

Stop the Seroquel gradually. My friend was diagnosed with bipolar disorder and was taking seroquel, 4 a night and he would become really grumpy, sleepy. It's like the psychiatrists needed to know if he is sleeping? It will cause weight gain, bloating and not getting the right medication that is needed. So let your doctor know about your symptoms. Believe me I have seen it first hand. He still has to take Lithium, Depakote, heart medication, meds for his thyroid, before he was waking up in the morning and shaking, now he feels better. And I hope you do to. My best for you in your endeavors. Good luck. Answered by Jan Holy 3 months ago.

I thank Jesus everyday, that I am finally off of this nightmarish merrry-go-round. These pills were prescribed to me by an idiot took a 11 year chunk out of my life. I am free of all those drugs. It was my faith in Jesus and that I know, ALL things with God are possible. If you only knew hell's landscape from which I have been save you too would be kissing his feet for salvation. There is no such thing as bi-polar. There are no blood tests, or scans or any other thing to measure for its existence. We are merely labeled these (diagnosis) and become slaves to these (ha hem) doctors because we believe them. Once this poison gets into you and changes your chemistry it is a horrific battle to get clean again. The (he hem) doctors won't help you. They just diagnose you with more labels and prescribe more pills. I was on 12 at one time. I am living proof that you can live a normal, happy life (in Christ) without popping something into your mouth because someone convinced you that you had some sort of chemical imbalance. WARNING: Never, Not EVER, take a benzodiazepine, especially for any length of time. I have done exhaustive research on BIG Pharm and what is going on out there. I am free of all chemicals. I am mentally, physically and spiritually healthy. And, I give the glory to Immanuel (God with us) for leading me out of that horrible prison. Answered by Merrill Fifield 3 months ago.


Can someone tell me how save is the Nardil, Mellaril,and Norpramin medication?
or how danger they could be for an 18-21 young men. and if you could be kind of telling me the streanth and color of the different pills of nardil. I don't ask for the others cause I have knoledge about it. thanks for your help Asked by Seymour Biffle 3 months ago.

Side Effects of Nardil: Some common side effects reported with this medicine include: upset stomach drowsiness weakness or tiredness excitement or anxiety insomnia nightmares dry mouth skin more sensitive to sunlight than usual changes in appetite or weight Excessive fluid retention in the body tissues, resulting in swelling (edema) Life-threatening progressive damage and destruction of the live. Never overdose even a little on this pill! If you miss a dose don't worry just ignore it! Talk to your pharmacist about any of the drugs you are taking, that's why they went to collage. I wouldn't take (mellaril) thioradzine it can lead to sudden death, no kidding! Stick with nardil! I myself also suggest you try mediation for mind, instead of feeding it drugs feed it quiet and peace! Answered by Dorene Wrape 3 months ago.


Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
011909/002 NARDIL PHENELZINE SULFATE TABLET/ORAL EQ 15MG BASE

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
011909/002 NARDIL PHENELZINE SULFATE TABLET/ORAL EQ 15MG BASE
200181/001 PHENELZINE SULFATE PHENELZINE SULFATE TABLET/ORAL EQ 15MG BASE

Manufacturers

Manufacturer name
Kyowa Kirin International

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