Application Information

This drug has been submitted to the FDA under the reference 020372/001.

Names and composition

"MYOVIEW" is the commercial name of a drug composed of TECHNETIUM TC-99M TETROFOSMIN KIT.


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Answered questions

Myoview treadmill test?
Next week i will be going for a myoview treadmill test and i am very nervous. I go through stress anxiety and depression. I'm a 46 y/o woman and i get shortness of breathe when i do physical things like mopping, pulling clothes out of the washer or talking while walking.I take no medication at all and if i had... Asked by Tory Neville 1 year ago.

Next week i will be going for a myoview treadmill test and i am very nervous. I go through stress anxiety and depression. I'm a 46 y/o woman and i get shortness of breathe when i do physical things like mopping, pulling clothes out of the washer or talking while walking.I take no medication at all and if i had to i would be very paranoid about it. I am very afraid about this test as i was told they would inject a small amount of radioactive in me and the whole Myoview testing would take 5 hours. I know i have to do this can anyone give me some feedback thank you. Answered by Lashandra Urtz 1 year ago.

No's better you find out what is giving you the shortness of breath and having them be able to treat it. A nuclear exercise stress test is a diagnostic test used to evaluate blood flow to the heart. A small amount of a radioactive substance is injected into your bloodstream at peak exercise. The level of radioactivity used is extremely low and has no side effects. This substance travels to the coronary arteries and distributes itself throughout your myocardium. A special camera measures the amount of radioactive material that reaches the heart muscle while you exercise. The gamma camera does not produce any radiation. These pictures are then compared to identify the size and location of poor blood supply or damage to our heart muscle. IMPORTANT: Please Read and Follow Instruction Carefully 1. For 24 hours before your test, please do not eat or drink any of the foods listed below. No coffee, or tea that is brewed, instant, iced or decaffeinated No colas, or other soft drinks that contain caffeine, including those labeled “caffeine – free” No chocolates, including candies, frosting, cookies, pies, cocoa, and chocolate milk No aspirin products that contain caffeine, such as Anacine and Excedrin Hope that helps. I have been on Medication for my heart for 20 years now, and it has helped me immensely. Taking medication is the least of your worries. Answered by Eunice Horvers 1 year ago.

Chemical bonds for tetrofosmin (myoview)?
Hello, I am studying nuclear medicine and I have a project. I have to make a molecular structure of the radiopharmaceutical 99mTc tetrofosmin. Well I have that model completed, but I have to do a presentation on it also. My problem is that I can not seem to find info on how the atoms bond together. Bonds like... Asked by Nettie Mentzel 1 year ago.

Hello, I am studying nuclear medicine and I have a project. I have to make a molecular structure of the radiopharmaceutical 99mTc tetrofosmin. Well I have that model completed, but I have to do a presentation on it also. My problem is that I can not seem to find info on how the atoms bond together. Bonds like covalent, ionic, etc... I have found some info but it is so far beyond what I'm trying to find. I just need someone to explain it to me in "English". Any help is appreciated. Thanks in advance. Answered by Dominga Mrotek 1 year ago.

What is gtx myoview stress test?
Why is it fasting and not fasting the next day. Is that necessary for a screening stress test? Asked by Ward Willenborg 1 year ago.

its to see your coronary artries , now fasting is to stress your heart and its for the better muscle view Answered by Annabelle Zaharis 1 year ago.

What is a Persantine Myoview? and Why would a doctor run this type of test?
Asked by Vanesa Conran 1 year ago.

It is a nuclear medicine test using a "dye" that is given in an IV. It helps show if you have any blockage in your coronary arteries of your heart. These are the arteries that supply blood to the heart muscle itself. If blockage is suspected then they may decide to do a heart catherization to get a better look at the arteries. When they do this they can put stents in the arteries to reopen them. Good luck and don't count your chickens until they are hatched!! Answered by Aisha Gregson 1 year ago.

First of all information between a doctor and a patient is confidential so the results should come to you. Secondly it depends what the test is for. Normally labs only make specific tests based on the doctor's instructions. If he hasn't asked for an AIDS test they won't do one. If. however, you think you are infected seek professional help immediately. Talk to your doctor about your concerns. If you do have it, and God forbid you do, then what your Mom knows doesn't matter, but the treatment does. If she's loving and caring she will understand and support you. Good luck and best wishes. If you turn out to be tested negative, and i hope you do, make sure you keep away from the previous bad influences and things that can cause AIDS. Answered by Caitlin Campusano 1 year ago.

This Site Might Help You. RE: What is a Persantine Myoview? and Why would a doctor run this type of test? Answered by Florrie Nelligan 1 year ago.

In a stress test nuclear scan what does "the gaited left ventricular ejection fraction is 0.65" mean?
and "normal rest/stress gaoled myoview scan" mean? Asked by Candice Opalka 1 year ago.

It means normal. Answered by Dahlia Kribbs 1 year ago.

it may mean out of 100% the stress you have is 65% i dont know the rest sorry just a guess ?? Answered by Darcel Hugee 1 year ago.

Had a nuclear stress test done today and i have a question?
my doctor was present during the scans after the treadmill and never even came to talk to me. he sent a nurse to tell me that i need to see him next week to discuss my results. i'm a bit worried. is it possible that the ekg can show nothing but the scans say different? Asked by Demetrius Slates 1 year ago.

i had my first nuclear stress test today. i had to have one done because my heart rate at resting is jumping from 104 to 130 and never getting any lower. i was scared but the techs and the staff allowed a friend to come in for support. that didn't make it so bad. but i did notice that after they gave me the first dye injection i became so thirsty and had to pee every 20 minutes it seemed. also my blood sugar went from 106-210 (i am a diabetic, i use pills to control it). they encouraged me to keep drinking but towards the end got annoyed that i had to use the bathroom so much. i understand i was just annoyed as they were. when it came time to get on the treadmill i was fine and i thought i was doing good. the ekg thingy (thing thats what it's called) showed no change in heart rythm just how fast my heart rate is. and the tech made the comment about how wonderful it was that it didn't but that i really needed to find out what caused me to hit my target rate in zone 1 by the time i got to zone 2 my heart rate was 175 when my target is only 164. is that something to be concerned about. i exercise everyday. i keep exercising till i can't talk, my legs feel rubbery, my head is feeling like its gonna explode, and i'm dizzy. i usually reach that feeling within 10-15 minutes of starting. they did scans also but nobody told me anything about them. Answered by Dyan Librizzi 1 year ago.

This is going to be a long one so I hope you don’t have ADD :-) -there are numerous reasons why your heart rate is jumping up and down. Although doubtful, it might be because you get real nervous at the Dr office. Try checking your own heart rate when you’re at home and relaxed like when you first wake up. -Your thirst and elevated glucose level did not have anything to do with the injections you received. There are 3 possible injections for a nuclear treadmill stress test. Depending on the facility you went to, you either received Thallium-201, Cardiolite (Sesta-MIBI), or Myoview. These are simply radioactive material used as an imaging agent and have no influence over your diabetes. Your high glucose levels are probably due to the fact that you were fasting and probably did not take your meds. That is why it is recommended that diabetic patients perform this test early in the mornings so they don’t fast for too long. -the fact that there were no EKG changes is a good thing but the fact that you reached your target on stage 1 is concerning. You left out a few things that are important …. What is your age? …. How long did you walk or what stage did you reach before the test was stopped? …. Who stopped the test: you or the tech and why (chest pain, tired, legs gave out, reached target)? -the images are what is important in this test. Im hoping you also had a resting scan for them to compare the stress images to. As far as the scans are concerned ….. how many different positions did you lay down for the pictures? The scans can be done laying on your back, on your stomach and on your side. The more positions they put you in, the better the results will be. - In my opinion, the fact that your doctor did not give you any results is a good thing. These are complex images with lots of info to look at. I would not want my Dr to just glance at it and come up with a conclusion. When you do see your Dr for results next week, make sure he explains to you 1. what the sliced images look like 2. what the wall motion looks like 3. what your ejection fraction (EF) is. - If I were you, I would get a 2nd opinion, no matter what the results are especially if the reading Dr is a just a Cardiologist. Make sure you get a copy of the films (not the results) and show them to a Radiologist that specializes in Nuclear Med. Im sorry I was not able to get specific about a lot of things but don’t be afraid to ask your Dr. For some reason people always forget what to ask when they get to the Dr office ….. I would suggest writing down all the questions that pop into your head this week and read them off when you see him next. Good luck. Answered by Noriko Spindler 1 year ago.

When he had his stress test, did he have to walk a treadmill, or did they give him medication to simulate the heart under stress like walking the treadmill. If they gave him medication that makes the heart beat as if he had walked the treadmill, it is possible that this could have caused some problems. I always have the medicine when I have a stress test because I have to take meds to slow my heart rate down and can never get my heart rate high enough when I walk a treadmill. Every time I am given the medication for the stress test, I am told there is the possibility of this medication causing a heart attack. I have never had an issue with it, but the possibility is there. I would not think that the medication given him for the nuclear stress test would still be causing a problem. He had the test because of a heart issue. I would suggest a trip to the ER. Answered by Arminda Schub 1 year ago.

I am 61 and weigh 138. I had my test done today and the technician told me I would go to stage 4 and stay there for 1 minute. I only went to stage 3 and continued for 30 seconds. I could of gone longer. I have no idea how long I was on the treadmill it didn t seem long at all. Won t get results till next week. I was done with everything in a little over 2 hours. What is wrong. I am stressed just waiting for results Answered by Flavia Zieg 1 year ago.

You should not exercise to the point of the symptoms you describe. I think the doc should have at least given you his preliminary diagnosis, which is appropriate BUT then I think you may not have been satisfied with the many possibilities he may have to give. He will review all of the info and by the time of your appointment, he will have more definitive results. He should have least told you this. I have copied some info below but I am not sure it answers your questions. That is why I have listed my source below which is an excellent site, I am sure you will find your answer. Please take a look at the informative site. As far as your blood sugar goes, the higher the blood sugar, the more you have to pee. Some of these injections raise the blood sugar. They should have known this if they knew you were diabetic. A nuclear stress test can help measure: Extent of artery blockage Prognosis of patients who have recently suffered a heart attack (myocardial infarction) Effectiveness of cardiac procedures previously performed, such as coronary stenting (in which a wire mesh metal tube is inserted into an artery to keep it open), or balloon angioplasty (in which a balloon-tipped catheter is used to push plaque back against artery walls, improving blood flow) Cause(s) of chest pain Level of exercise that a patient can safely perform Results can indicate any of the following: If the test is normal during times of both exertion and rest, then blood flow is adequate and there is no scarring of the heart muscle. If the test showed the same abnormality during both exertion and rest, then this part of the heart has most likely been scarred and damaged by a previous heart attack. If the test is normal during rest, but abnormal during stress or exertion, then a blockage in one or more arteries may exist. If there is a resting abnormality that becomes worse during stress, this indicates both heart attack and reversible ischemia Answered by Yolando Deaner 1 year ago.

My husband had a nuclear stress test today and could not get his heart rate up to 150 as requested. He just had a heart attack 6 weeks ago and had a stent inserted in one artery. Should I be worried? Answered by Erline Gettens 1 year ago.

What are the advantages of SPECT imaging in Cardiology?
Are there any real advantages to SPECT imaging of the heart as opposed to, for example, a hybrid SPECT/CT, MRI, or PET scan? Any advantages to the hybrids? Asked by Raphael Frangione 1 year ago.

Myocardial perfusion imaging Myocardial perfusion imaging (MPI) is a form of functional cardiac imaging, used for the diagnosis of ischemic heart disease. The underlying principle is that under conditions of stress, diseased myocardium receives less blood flow than normal myocardium. MPI is one of several types of cardiac stress test. A cardiac specific radiopharmaceutical is administered. E.g. 99mTc-tetrofosmin (Myoview, GE healthcare), 99mTc-sestamibi (Cardiolite, Bristol-Myers Squibb). Following this, the heart rate is raised to induce myocardial stress, either by exercise or pharmacologically with adenosine, dobutamine or dipyridamole (aminophylline can be used to reverse the effects of dipyridamole). Single photon emission computed tomography (SPECT, or less commonly, SPET SPECT imaging performed after stress reveals the distribution of the radiopharmaceutical, and therefore the relative blood flow to the different regions of the myocardium. Diagnosis is made by comparing stress images to a further set of images obtained at rest. As the radionuclide redistributes slowly, it is not usually possible to perform both sets of images on the same day, hence a second attendance is required 1-7 days later (although, with a Tl-201 myocardial perfusion study with dipyridamole, rest images can be acquired as little as two-hours post stress). However, if stress imaging is normal, it is unnecessary to perform rest imaging, as it too will be normal – thus stress imaging is normally performed MPI has been demonstrated to have an overall accuracy of about 83% (sensitivity: 85%; specificity: 72%), and is comparable with (or better than) other non-invasive tests for ischemic heart disease, including stress echocardiography. Answered by Precious Feinstein 1 year ago.

taf C. Van Cauter on how imaging techniques measure up. NGP. What are the major disadvantages of using traditional invasive techniques to study models of human disease in small animals? Staf Va Cauter. While animal experimentation remains central to our understanding of human disease-related processes and the biological effects of many substances, it is quite unfortunate that most experiments still rely heavily on invasive techniques requiring animals to be sacrificed for histo-pathological assessment. This is done to track the progression or regression of disease over time, or to determine the levels of toxicity in specific organs or tissues. However, these invasive techniques fail to provide details of how a disease develops or how a substance elicits its effects. Non-invasive imaging techniques on the other hand allow diseases, and responses to substances, to be monitored in-vivo, over time. One avoids sacrificing animals and obtains more information from fewer animals, thus increasing the statistical validity of the data by reducing the level of experimental variation. NGP. How can PET and SPECT provide the sensitivities required to obtain the same physiological imaging acuity in small animals as can be obtained from humans? SVC. The ability to penetrate tissues makes PET and SPECT imaging techniques suitable for both small animals and humans. Results obtained in small animals can thus be translated to a clinical setting in humans. However, there is one big challenge: a mouse is more than 1000 times less massive than a human. In other words, mice are at least ten times smaller in each dimension than humans. Therefore, if imaging studies in mice are to be “equivalent” to human studies, the spatial resolution of an animal scanner must be about ten times better than a human scanner. Typical human scanners achieve resolutions of 6 mm or less in humans. The scaled-up resolution to achieve anatomical parody for a mouse is < 1mm, or in volumetric terms, in the nanoliter range. This can only be accomplished by using the new generation nanoSPECT and nanoPET scanners Answered by Elizebeth Trest 1 year ago.

Ride home after a stress test?
My husband is having a stress test today. Will he be ok to drive himself home or should I go pick him up? Asked by Crystal Gries 1 year ago.

He can drive himself home. The only exception would be a persantine myoview stress type of testing, this medication has a very long half-life and if has a poor reaction to it he may not feel up to driving himself. Otherwise, he should be fine. The technicians will be monitoring him and will not allow him to go home if there are any concerns at that time. Always remember however, stress testing cannot predict or prevent future heart attack, so if he is having symptoms that last more than 5 minutes without relief, he should not wait to follow up with his doctor and just proceed to the hospital immediately. Answered by Ma Marbry 1 year ago.

Air on the side of caution pick him up. His present health is unstated and the effects may or may not be severe. Answered by Loise Fillingim 1 year ago.

What other ways can doctors study heart damage?
What are others means of diagnosis of heart damage, besides conventional methods? as my doctors intends to proceed further investigation. Asked by Adena Wallingford 1 year ago.

* Coronary angiography * Echocardiogram and ultrasound examination of the heart. *Tc99 or Thallium or Myoview (Nuclear Scan) * Chest CT scan * MRI of chest * ECG Rarely, a heart biopsy performed during a heart catheterization may be needed to rule out other disorders. The following lab tests may be used to rule out other disorders and to assess the condition of the heart: Answered by Wyatt Pancheri 1 year ago.

Well, that depends on what you consider conventional. I don't know what you've had done so far but methods of diagnosis include: blood work, EKG, X-rays, CT scans, MRI, stress tests, Cardiac catheterization, CT angiograms...those are the most common. Hope this helps. Good luck! Answered by Dorothea Orison 1 year ago.

Echocardiogram, MUGA scan, MRI, Angiography, Open heart surgery, Autopsy Answered by Tristan Welty 1 year ago.

there are many types of tests, soon after heart damage quantity of certain enzymes is increased in blood by analysing this quantity they determine infraction. other test are, Doppler, Echo, Angiography, MRI, Chorated, Sress test etc. Answered by Elroy Crotts 1 year ago.


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