Application Information

This drug has been submitted to the FDA under the reference 017744/002.

Names and composition

"MOTOFEN" is the commercial name of a drug composed of ATROPINE SULFATE and DIFENOXIN HYDROCHLORIDE.

Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
017744/002 MOTOFEN ATROPINE SULFATE; DIFENOXIN HYDROCHLORIDE TABLET/ORAL 0.025MG and 1MG

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
017744/001 MOTOFEN HALF-STRENGTH ATROPINE SULFATE; DIFENOXIN HYDROCHLORIDE TABLET/ORAL 0.025MG and 0.5MG
017744/002 MOTOFEN ATROPINE SULFATE; DIFENOXIN HYDROCHLORIDE TABLET/ORAL 0.025MG and 1MG

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Answered questions

Does anyone know where to get the medication Motofen?
Any pharmacists out there who still have some on their shelf? Its an antidiarrheal and has been the only drug to work for my condition. I have tried all of them and this one is perfect as far as i am concerned. Has giving me a normal life and now it has been taken off the market for a while. My dr gives me a Rx for... Asked by Tran Pander 1 year ago.

Any pharmacists out there who still have some on their shelf? Its an antidiarrheal and has been the only drug to work for my condition. I have tried all of them and this one is perfect as far as i am concerned. Has giving me a normal life and now it has been taken off the market for a while. My dr gives me a Rx for it when i find it buts its not easy to find. Anyone know of any still out there? Answered by Emmett Sandau 1 year ago.

Oct 8 2009, 08:53 PM Post #1 New Member Posts: 17 Joined: 9-August 05 I spoke with a Valeant representative tonight-she said motofen will be available somewhere between December 1 and December 15. She said she would call me when there is a definite date of motofen's availability.For those of us who were taking motofen and enjoying relief fron this chronic disease-this is great news. When I hear anything more specific I will post it here, Answered by Vonnie Regalado 1 year ago.

Motofen Availability Answered by Junko Buris 1 year ago.


Is there a way to make the prescription drug Motofen?
I have been taking Motofen for about 5 years. It changed my life. Made my life "normal". Now it has been taking off the market and I am miserable without it. Is there a way to make Motofen? It is Difenoxin and Atropine. Is there anyway to use other drugs to make it, or make something close to it? Would it... Asked by Azzie Rohner 1 year ago.

I have been taking Motofen for about 5 years. It changed my life. Made my life "normal". Now it has been taking off the market and I am miserable without it. Is there a way to make Motofen? It is Difenoxin and Atropine. Is there anyway to use other drugs to make it, or make something close to it? Would it be legal? Answered by Emogene Rego 1 year ago.

No, you cannot make a prescription drug from some sort of home recipe. That's why its a prescription. If your doctor has had you on this med for years and it has been working well for you, he will certainly put you on something similar now. Answered by Angela Stamps 1 year ago.


Are there any other medications to control cronic diarriea other than motofen lomoto and imodium?
I have Crohns disease and a lot of intestine removed and have been taking motofen with great results for about 15 years and now I am unable to obtain it. Its manfacturer has stopped making it & I have been unble to find anything to replace it. Asked by Ashlyn Bare 1 year ago.

Yes there is. Its called Lonox, generic lomotil. It is considered to be a controlled substance in the state of NY, but it is out there. Answered by Belia Youmans 1 year ago.


Would taking pain killers help my IBS?
I used to take Motofen which is similar to pain killers but it has since been taken off the market. I have taken pain killers recently for a tooth problem. My stomach has been better then fine it works just like Motofen. I heard of people taking codeine tinctures I believe I am not too sure, to help with this... Asked by Kit Koelle 1 year ago.

I used to take Motofen which is similar to pain killers but it has since been taken off the market. I have taken pain killers recently for a tooth problem. My stomach has been better then fine it works just like Motofen. I heard of people taking codeine tinctures I believe I am not too sure, to help with this problem. Anyone have any advice, ideas if it would work, know anyone who uses it? Also could I take xanax along with that to calm me down so I do not have attacks in bad situations. Answered by Marcus Scorsone 1 year ago.

no it wont help you dont want to keep taking pain killers for IBS its a false help Answered by Carlo Bonura 1 year ago.

pain killers ibs Answered by Genna Belair 1 year ago.

I have UC and pain killers don't work like that, the only thing that helps for me if I have an attack is prednizone. If anything, the pain killers could make your IDS worse. You should check with your Dr. and see if he can give you something. Answered by Stefani Loughary 1 year ago.


How can Lomotil aka Lonox be abused?
How can you abuse a drug like that? it is for diarrhea. How does someone separate the med in a pill? I am just curious I am not planning to actually do it. I read about it and it says atropine is added to keep ppl from abusing it but I am wondering how and why would you abuse a med like this? Asked by Dana Oransky 1 year ago.

Yes Lomotil (diphenoxylate/atropine) can be theoretically abused. Diphenoxylate, loperamide, the active ingredient in Imodium, and difenoxin (Motofen) are opioid agonists. Difenoxin is also an active metabolite of diphenoxylate. Like other opioids diphenoxylate causes constipation and is thus a very effective treatment for diarrhea. Opioid receptor sites are found in the gastrointestinal tract, spinal cord, and brain. Diphenoxylate however only slightly crosses the blood brain barrier (BBB) but at therapeutic doses does not cause euphoria, analgesia, or other morphine-like effects. Loperamide however does NOT cross the BBB. At high doses, 40-60 mg, diphenoxylate may produce euphoria, suppression of opioid withdrawal (abstinence syndrome), and physical dependence after chronic administration. Evidence of physical dependence to diphenoxylate has been reported when it is used long term even at recommended dosage. Preparations of diphenoxylate contain a subtherapeutic quantity of atropine, which can cause severe nausea and weakness, to discourage deliberate overdosage. The Health Canada Product Monograph for Lomotil tablets (2.5 mg diphenoxylate/0.025 mg atropine) indicates the following under the Dependence Liability section: "Addiction to (dependency on) LOMOTIL is theoretically possible at high dosage. Therefore, the recommended dosage should not be exceeded. Because of the structural and pharmacological similarity of diphenoxylate to meperidine [Brand name DEMEROL] and similar drugs with a definite addiction potential, LOMOTIL should be administered with considerable caution to patients who are receiving addicting drugs, to individuals known to be addiction-prone, or to those whose histories suggest that they may increase the dosage on their own initiative. Because a subtherapeutic dose of atropine has been added to the diphenoxylate hydrochloride, to discourage deliberate overdosage, there should be strict observance of the contraindications and precautions relative to the use of atropine." In The United States Lomotil is a federally controlled schedule V substance. Motofen (difenoxin/ atropine) is a prescription medication in The US and it is a federally controlled schedule IV substance (the same level as phenobarbital, Darvocet, Valium, and Tenuate). Just because a drug is for something like diarrhea does not mean it can't be abused. Actually Opium Tincture (once known as Laudanum), a schedule II controlled substance, is FDA approved for the treatment of diarrhea. Answered by Tegan Ruderman 1 year ago.

This Site Might Help You. RE: How can Lomotil aka Lonox be abused? How can you abuse a drug like that? it is for diarrhea. How does someone separate the med in a pill? I am just curious I am not planning to actually do it. I read about it and it says atropine is added to keep ppl from abusing it but I am wondering how and why would you abuse a med like this? Answered by Ruben Seleg 1 year ago.

Diphen Atropine Answered by Yon Talamantez 1 year ago.

These opiate effects are seen with like 20 tabs and the atropine isn't really noticible for me so I like it. Answered by Leatrice Whispell 1 year ago.

You can't. Have fun being backed up if you do try it! Answered by Cathy Atay 1 year ago.


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