Application Information

This drug has been submitted to the FDA under the reference 019415/002.

Names and composition

"METRODIN" is the commercial name of a drug composed of UROFOLLITROPIN.

Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
019415/002 METRODIN UROFOLLITROPIN INJECTABLE/INTRAMUSCULAR 75 IU per AMP
019415/003 METRODIN UROFOLLITROPIN INJECTABLE/INTRAMUSCULAR 150 IU per AMP

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
019415/002 METRODIN UROFOLLITROPIN INJECTABLE/INTRAMUSCULAR 75 IU per AMP
019415/003 METRODIN UROFOLLITROPIN INJECTABLE/INTRAMUSCULAR 150 IU per AMP
019415/004 FERTINEX UROFOLLITROPIN INJECTABLE/SUBCUTANEOUS 150 IU per AMP
019415/005 FERTINEX UROFOLLITROPIN INJECTABLE/SUBCUTANEOUS 75 IU per AMP
021289/001 BRAVELLE UROFOLLITROPIN INJECTABLE/INTRAMUSCULAR, SUBCUTANEOUS 75 IU per VIAL
021484/001 BRAVELLE UROFOLLITROPIN Injectable/ Subcutaneous 0.9%

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Answered questions

Ive been diagnosed with polycystic ovarian syndrome...?
and my dr prescribed me metformin n the birth controll pill, ii only wave to take metformin once n only for 2 weeks, to bring on a period, n thn the sunday after my period, i have tot start taking the yasmin birth controll pill, i was wondering the size of the metformin pill and if there are any side effects to... Asked by Janeth Ziencina 1 year ago.

and my dr prescribed me metformin n the birth controll pill, ii only wave to take metformin once n only for 2 weeks, to bring on a period, n thn the sunday after my period, i have tot start taking the yasmin birth controll pill, i was wondering the size of the metformin pill and if there are any side effects to metfromin and the yasmin birth controll pill???? Answered by Loise Spratte 1 year ago.

Did you mean Metformin or Metrodin? Metrodin IM is used to treat the following: Infertility associated with the Lack of Ovulation, Female Problems Causing Trouble in Getting Pregnant, Stimulation of Ovarian Function, Stimulation of Ovarian Follicle, Ovary Follicle Stimulation for Assisted Fertility Procedures Metformin is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes (non-insulin-dependent diabetes). Controlling high blood sugar helps prevent heart disease, strokes, kidney disease, blindness, circulation problems, and decreased sexual ability. Metformin belongs to the class of drugs known as biguanides. It works by helping to restore your body's proper response to the insulin you naturally produce, and by decreasing the amount of sugar that your liver makes and that your stomach/intestines absorb. Check WebMD if you have any questions about any medication. They usually have all he right answers. Please tell me what your symptoms are and what kind of tests you had to do to determine you have PCOS. I have been doing some reading and I think I may have it also. I want to take some literature to my gyno and ask for a test if there is one. Answered by Raye Dreiling 1 year ago.


What is fertility examination?
Asked by Katheleen Morale 1 year ago.

Routine Fertility Workup The following is a listing of tests generally included in a routine fertility work-up. Please note that every reproductive endocrinologist (RE) has his or her own standard protocol, and the following is intended to be a basic guideline. If you are not seeing an RE and your OB/GYN does not have the facilities to conduct these routine tests, you should seriously consider switching to a doctor who does. Minimally, a doctor treating fertility patients should have the following: 1. Availability of staff and technicians seven days per week. If your doctor or clinic does not offer weekend and holiday hours, you are clearly not in the hands of someone whose priority is helping you get pregnant. 2. Transvaginal ultrasound equipment. You should not undergo clomid, metrodin or pergonal treatment unless this equipment is available for routine monitoring. Though many OBs prescribe Clomid without doing this monitoring, it is in your best interest to have periodic ultrasounds to ensure that the Clomid is indeed stimulating ovulation and that the follicles are releasing the eggs. Under no circumstances should a patient undergo metrodin or pergonal treatment without ultrasound monitoring. If you are using intra-uterine insemination (IUIs), ultrasounds are required for accurately timing insemination with ovulation. 3. An on-site, certified lab to do semen testing and prep for IUIs and post coital tests, as well as facilities to do E-2, blood HCG beta and progesterone tests. YOUR FIRST APPOINTMENT: Try to schedule your first appointment with your RE during the first week of your cycle. This will enable him/her to take baseline levels of FSH (follicle stimulating hormone) and LH (lutenizing hormone). Most REs also do routine screening of both partners---AIDS, hepatitis, etc. Medical histories for both partners will be taken. Try to keep track of the length of your menstrual cycles for several months beforehand. Charting Basal Body Temps (BBTs) for several months will also give your doctor some insights---as will using home Ovulation Predictor Kits and recording the results. YOUR SECOND APPOINTMENT: This appointment should be scheduled on the day of LH surge---BEFORE ovulation. In most cases, you will be directed to use home ovulation test kits and call for an appointment on the day you detect a surge. Included in this exam will be: CERVICAL MUCUS TESTS: including a post-coital test (PCT) to see that sperm can penetrate and survive in the cervical mucus, and a bacterial screening. It is important to note that the appropriate time to do PCTs is just before ovulation when mucus is the most "fertile." PCTs at other times may give false results. ULTRASOUND EXAM(S): On the day of LH surge are used to assess the thickness of the endometrium (lining of the uterus), monitor follicle development and assess the condition of the uterus and ovaries. If the lining is thin, it indicates a hormonal problem. Fibroid tumors can often be detected via ultrasound, as well as abnormalities of the shape of the uterus and ovarian cysts. In some cases, endometriosis can also be detected. Many doctors order a second ultrasound two or three days after the first. This second ultrasound confirms that the follicle actually did release and can rule out lutenized unruptured follicle (LUF) syndrome---a situation in which eggs ripen but do not release from the follicle. HORMONE TESTS: if the blood test at your first appointment indicated a high LH to FSH ratio, an indication of polycystic ovarian disease (PCOD), your doctor will order an "Androgen Panel" to check levels of free testosterone and dihydroeprandrostone (DHEAS). Other tests tests that should be conducted on the day of LH surge include LH, FSH, Estradiol and Progesterone. Tests which can be done at any time (and therefore done at the second appointment) include: Prolactin, Thyroid Stimulating Hormone (TSH), Free T3, Free Thyroxine (T4), Total Testosterone, Free Testosterone, DHEAS and Androstenedione. The normal hormone levels for each of these during specific parts of your cycle are as follows: Lutenizing Hormone (LH) Follicular Phase (day two or three): <7miu/ml Day of LH Surge: >15mIU/ml Follicle Stimulating Hormone (FSH) Follicular Phase: <13miu/ml Day of LH Surge: >15 mIU/ml Estradiol Day of LH Surge: >100 pg/ml Mid Luteal Phase (seven days after O): >60 pg/ml Progesterone Day of LH Surge: <1.5 ng/ml Mid Luteal Phase >15 ng/ml Prolactin: <25 ng/ml Thyroid Stimulating Hormone (TSH): 0.4 to 3.8 uIU/ml Free T3: 1.4 to 4.4 pg/ml Free Thyroxine (T4): 0.8 to 2.0 ng/dl Total Testosterone: 6.0 to 89 ng/dl Free Testosterone: 0.7 to 3.6 pg/ml DHEAS: 35 TO 430 UG/DL Androstenedione: 0.7 to 3.1 ng/ml <= less than;>= greater than; mIU=milli International Units; ml=milliliter; pg=picograms; ng=nanograms; uIU=micro International Units; dl=deciliter; ug=micrograms NOTE: These levels are those used at the Chapel Hill Fertility Center laboratory, and have been excerpted from "The Couple's Guide to Fertility" by Berger, Goldstein and Fuerst, published by Doubleday. ADDITIONAL TESTING: After the initial workup, many doctors continue with some of the following tests. HYSTEROSALPINOGRAM (HSG): This test is used to examine a woman's uterus and fallopian tubes. It is essentially an x-ray procedure in which a radio-opaque dye is injected through the cervix into the uterus and fallopian tubes. This "dye" appears white on the x-ray, and allows the radiologist and your doctor to see if there are any abnormalities, such as an unusually shaped uterus, tumors, scar tissue or blockages in the fallopian tubes. If you are trying to get pregnant in the same cycle as an HSG, make sure to schedule the test PRIOR to ovulation so that there is no danger of "flushing out" a released egg or developing embryo. Although most women report only minor cramping and short-term discomfort during this procedure, some women, especially those who DO have blockages, report intense pain. Speak to your doctor about taking a pain medication about 30 minutes prior to the actual procedure. HYSTEROSCOPY: If a uterine abnormality is suspected after the HSG, your doctor may opt for this procedure, performed with a thin telescope mounted with a fiber optic light, called a hysteroscope. The hysteroscope is inserted through the cervix into the uterus and enables the doctor to see any uterine abnormalities or growths. "Photos" are taken for future reference. This procedure is usually performed in the early half of a woman's cycle so that the build-up of the endometrium does not obscure the doctor's view. However, if the doctor is planning to do an endometrial biopsy at the same time, it is done near the end of the cycle. LAPAROSCOPY: A narrow fiber optic telescope is inserted through a woman's abdomen to look at the uterus, fallopian tubes, and ovaries and to discern endometriosis or pelvic adhesions, and is the best diagnostic tool for evaluating the ovaries. This test us usually done two or three days before menstruation is expected, and only after an HCG beta blood test ensures the woman is not pregnant. ENDOMETRIAL BIOPSY:This procedure involves a scraping a small amount of tissue from the endometrium shortly before menstruation is due--- between 11 and 13 days from LH surge. It should ONLY be performed after an HCG blood test shows the woman is not pregnant. This test is used to determine if a woman has a luteal phase defect, a hormonal imbalance which prevents a woman from sustaining a pregnancy because not enough progesterone is produced. Information compiled by: Theresa Venet Grant Public Information Director InterNational Concil on Infertility Information Dissemination (INCIID) Answered by Jesse Canella 1 year ago.


Is there any type of medications that make one fertile?
I was wondering is there any type of medications used for depression or certain cancers that can make one fertile? I mean anytype of medications other than fertility medications. Asked by Sherice Schmidt 1 year ago.

I'm not sure why you would use an anti-depressant for fertility. Clomid or Serophene (clomiphene citrate) Indication: Clomid is often the first choice for treating infertility because it's effective and been used for more than 25 years. Clomiphene is given to women who are not ovulating normally. Clomid and Serophene, the brand names of clomiphene, are antiestrogen drugs. As a result, they cause the hypothalamus and pituitary gland located deep in the brain to release hormones that will stimulate the ovaries to produce eggs. GnRH is released from the hypothalamus and FSH and LH are released from the pituitary gland. These fertility drugs are often used in combination with assisted reproductive techniques or artificial insemination. Use: The typical starting dosage of clomiphene is 50 milligrams per day for five days. You take the first pill on the third, fourth, or fifth day after you start your period. You can expect to start ovulating about seven days after you've taken the last dose of the drug. If you don't ovulate right away, the dose can be increased by 50 milligrams per day each month up to 150 mg. After you've begun to ovulate, most doctors suggest taking clomiphene for no longer than six months. If you haven't become pregnant by then, your doctor will probably prescribe a different medication. Effectiveness: Approximately 60% to 80% of women who take clomiphene will ovulate, and about half will be able to get pregnant as a result of taking the drug. Most pregnancies occur within three cycles. Side effects: The side effects of clomiphene are generally mild. They include hot flashes, blurred vision, nausea, bloating, and headache. Clomid can also cause changes in the cervical mucus, which may make it harder to tell when you're fertile and may inhibit the sperm from entering the uterus. Like many fertility drugs, Clomid can increase the chances of multiple births, although it's less likely to cause the problem than some injectable hormones. Injectable Hormones If Clomid on its own isn't successful, your doctor may recommend injectable hormones to stimulate ovulation. Some of the types are: Human Chorionic Gonadotropin (hCG), such as Pregnyl, Novarel, Ovidrel, and Profasi. This drug is usually used along with other fertility drugs to trigger the ovaries to release the mature egg or eggs. Follicle Stimulating Hormone (FSH), such as Follistim, Fertinex, Bravelle, and Gonal-F Human Menopausal Gonadotropin (hMG), such as Pergonal, Repronex, and Metrodin. This drug combines both FSH and LH. Gonadotropin Releasing Hormone (Gn-RH), such as Factrel and Lutrepulse. This hormone stimulates the release of FSH and LH from the pituitary gland. These hormones are rarely prescribed in the U.S. Gonadotropin Releasing Hormone Agonist (GnRH agonist), such as Lupron, Zoladex, and Synarel Gonadotropin Releasing Hormone Antagonist (GnRH antagonist), such as Antagon and Cetrotide Answered by Doloris Melvin 1 year ago.

noway... you need fertiley treatment and that costs thousands of dollars Answered by Jimmy Rocher 1 year ago.


Ive been diagnosed with polycystic ovarian syndrome...?
and my dr prescribed me metformin n the birth controll pill, ii only wave to take metformin once n only for 2 weeks, to bring on a period, n thn the sunday after my period, i have tot start taking the yasmin birth controll pill, i was wondering the size of the metformin pill and if there are any side effects to... Asked by Refugio Wubnig 1 year ago.

and my dr prescribed me metformin n the birth controll pill, ii only wave to take metformin once n only for 2 weeks, to bring on a period, n thn the sunday after my period, i have tot start taking the yasmin birth controll pill, i was wondering the size of the metformin pill and if there are any side effects to metfromin and the yasmin birth controll pill???? Answered by Lindsey Mceachern 1 year ago.

Did you mean Metformin or Metrodin? Metrodin IM is used to treat the following: Infertility associated with the Lack of Ovulation, Female Problems Causing Trouble in Getting Pregnant, Stimulation of Ovarian Function, Stimulation of Ovarian Follicle, Ovary Follicle Stimulation for Assisted Fertility Procedures Metformin is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes (non-insulin-dependent diabetes). Controlling high blood sugar helps prevent heart disease, strokes, kidney disease, blindness, circulation problems, and decreased sexual ability. Metformin belongs to the class of drugs known as biguanides. It works by helping to restore your body's proper response to the insulin you naturally produce, and by decreasing the amount of sugar that your liver makes and that your stomach/intestines absorb. Check WebMD if you have any questions about any medication. They usually have all he right answers. Please tell me what your symptoms are and what kind of tests you had to do to determine you have PCOS. I have been doing some reading and I think I may have it also. I want to take some literature to my gyno and ask for a test if there is one. Answered by Buford Mcsween 1 year ago.


What is fertility examination?
Asked by Adrien Ida 1 year ago.

Routine Fertility Workup The following is a listing of tests generally included in a routine fertility work-up. Please note that every reproductive endocrinologist (RE) has his or her own standard protocol, and the following is intended to be a basic guideline. If you are not seeing an RE and your OB/GYN does not have the facilities to conduct these routine tests, you should seriously consider switching to a doctor who does. Minimally, a doctor treating fertility patients should have the following: 1. Availability of staff and technicians seven days per week. If your doctor or clinic does not offer weekend and holiday hours, you are clearly not in the hands of someone whose priority is helping you get pregnant. 2. Transvaginal ultrasound equipment. You should not undergo clomid, metrodin or pergonal treatment unless this equipment is available for routine monitoring. Though many OBs prescribe Clomid without doing this monitoring, it is in your best interest to have periodic ultrasounds to ensure that the Clomid is indeed stimulating ovulation and that the follicles are releasing the eggs. Under no circumstances should a patient undergo metrodin or pergonal treatment without ultrasound monitoring. If you are using intra-uterine insemination (IUIs), ultrasounds are required for accurately timing insemination with ovulation. 3. An on-site, certified lab to do semen testing and prep for IUIs and post coital tests, as well as facilities to do E-2, blood HCG beta and progesterone tests. YOUR FIRST APPOINTMENT: Try to schedule your first appointment with your RE during the first week of your cycle. This will enable him/her to take baseline levels of FSH (follicle stimulating hormone) and LH (lutenizing hormone). Most REs also do routine screening of both partners---AIDS, hepatitis, etc. Medical histories for both partners will be taken. Try to keep track of the length of your menstrual cycles for several months beforehand. Charting Basal Body Temps (BBTs) for several months will also give your doctor some insights---as will using home Ovulation Predictor Kits and recording the results. YOUR SECOND APPOINTMENT: This appointment should be scheduled on the day of LH surge---BEFORE ovulation. In most cases, you will be directed to use home ovulation test kits and call for an appointment on the day you detect a surge. Included in this exam will be: CERVICAL MUCUS TESTS: including a post-coital test (PCT) to see that sperm can penetrate and survive in the cervical mucus, and a bacterial screening. It is important to note that the appropriate time to do PCTs is just before ovulation when mucus is the most "fertile." PCTs at other times may give false results. ULTRASOUND EXAM(S): On the day of LH surge are used to assess the thickness of the endometrium (lining of the uterus), monitor follicle development and assess the condition of the uterus and ovaries. If the lining is thin, it indicates a hormonal problem. Fibroid tumors can often be detected via ultrasound, as well as abnormalities of the shape of the uterus and ovarian cysts. In some cases, endometriosis can also be detected. Many doctors order a second ultrasound two or three days after the first. This second ultrasound confirms that the follicle actually did release and can rule out lutenized unruptured follicle (LUF) syndrome---a situation in which eggs ripen but do not release from the follicle. HORMONE TESTS: if the blood test at your first appointment indicated a high LH to FSH ratio, an indication of polycystic ovarian disease (PCOD), your doctor will order an "Androgen Panel" to check levels of free testosterone and dihydroeprandrostone (DHEAS). Other tests tests that should be conducted on the day of LH surge include LH, FSH, Estradiol and Progesterone. Tests which can be done at any time (and therefore done at the second appointment) include: Prolactin, Thyroid Stimulating Hormone (TSH), Free T3, Free Thyroxine (T4), Total Testosterone, Free Testosterone, DHEAS and Androstenedione. The normal hormone levels for each of these during specific parts of your cycle are as follows: Lutenizing Hormone (LH) Follicular Phase (day two or three): <7miu/ml Day of LH Surge: >15mIU/ml Follicle Stimulating Hormone (FSH) Follicular Phase: <13miu/ml Day of LH Surge: >15 mIU/ml Estradiol Day of LH Surge: >100 pg/ml Mid Luteal Phase (seven days after O): >60 pg/ml Progesterone Day of LH Surge: <1.5 ng/ml Mid Luteal Phase >15 ng/ml Prolactin: <25 ng/ml Thyroid Stimulating Hormone (TSH): 0.4 to 3.8 uIU/ml Free T3: 1.4 to 4.4 pg/ml Free Thyroxine (T4): 0.8 to 2.0 ng/dl Total Testosterone: 6.0 to 89 ng/dl Free Testosterone: 0.7 to 3.6 pg/ml DHEAS: 35 TO 430 UG/DL Androstenedione: 0.7 to 3.1 ng/ml <= less than;>= greater than; mIU=milli International Units; ml=milliliter; pg=picograms; ng=nanograms; uIU=micro International Units; dl=deciliter; ug=micrograms NOTE: These levels are those used at the Chapel Hill Fertility Center laboratory, and have been excerpted from "The Couple's Guide to Fertility" by Berger, Goldstein and Fuerst, published by Doubleday. ADDITIONAL TESTING: After the initial workup, many doctors continue with some of the following tests. HYSTEROSALPINOGRAM (HSG): This test is used to examine a woman's uterus and fallopian tubes. It is essentially an x-ray procedure in which a radio-opaque dye is injected through the cervix into the uterus and fallopian tubes. This "dye" appears white on the x-ray, and allows the radiologist and your doctor to see if there are any abnormalities, such as an unusually shaped uterus, tumors, scar tissue or blockages in the fallopian tubes. If you are trying to get pregnant in the same cycle as an HSG, make sure to schedule the test PRIOR to ovulation so that there is no danger of "flushing out" a released egg or developing embryo. Although most women report only minor cramping and short-term discomfort during this procedure, some women, especially those who DO have blockages, report intense pain. Speak to your doctor about taking a pain medication about 30 minutes prior to the actual procedure. HYSTEROSCOPY: If a uterine abnormality is suspected after the HSG, your doctor may opt for this procedure, performed with a thin telescope mounted with a fiber optic light, called a hysteroscope. The hysteroscope is inserted through the cervix into the uterus and enables the doctor to see any uterine abnormalities or growths. "Photos" are taken for future reference. This procedure is usually performed in the early half of a woman's cycle so that the build-up of the endometrium does not obscure the doctor's view. However, if the doctor is planning to do an endometrial biopsy at the same time, it is done near the end of the cycle. LAPAROSCOPY: A narrow fiber optic telescope is inserted through a woman's abdomen to look at the uterus, fallopian tubes, and ovaries and to discern endometriosis or pelvic adhesions, and is the best diagnostic tool for evaluating the ovaries. This test us usually done two or three days before menstruation is expected, and only after an HCG beta blood test ensures the woman is not pregnant. ENDOMETRIAL BIOPSY:This procedure involves a scraping a small amount of tissue from the endometrium shortly before menstruation is due--- between 11 and 13 days from LH surge. It should ONLY be performed after an HCG blood test shows the woman is not pregnant. This test is used to determine if a woman has a luteal phase defect, a hormonal imbalance which prevents a woman from sustaining a pregnancy because not enough progesterone is produced. Information compiled by: Theresa Venet Grant Public Information Director InterNational Concil on Infertility Information Dissemination (INCIID) Answered by Tifany Letbetter 1 year ago.


Is there any type of medications that make one fertile?
I was wondering is there any type of medications used for depression or certain cancers that can make one fertile? I mean anytype of medications other than fertility medications. Asked by Edwina Gremmels 1 year ago.

I'm not sure why you would use an anti-depressant for fertility. Clomid or Serophene (clomiphene citrate) Indication: Clomid is often the first choice for treating infertility because it's effective and been used for more than 25 years. Clomiphene is given to women who are not ovulating normally. Clomid and Serophene, the brand names of clomiphene, are antiestrogen drugs. As a result, they cause the hypothalamus and pituitary gland located deep in the brain to release hormones that will stimulate the ovaries to produce eggs. GnRH is released from the hypothalamus and FSH and LH are released from the pituitary gland. These fertility drugs are often used in combination with assisted reproductive techniques or artificial insemination. Use: The typical starting dosage of clomiphene is 50 milligrams per day for five days. You take the first pill on the third, fourth, or fifth day after you start your period. You can expect to start ovulating about seven days after you've taken the last dose of the drug. If you don't ovulate right away, the dose can be increased by 50 milligrams per day each month up to 150 mg. After you've begun to ovulate, most doctors suggest taking clomiphene for no longer than six months. If you haven't become pregnant by then, your doctor will probably prescribe a different medication. Effectiveness: Approximately 60% to 80% of women who take clomiphene will ovulate, and about half will be able to get pregnant as a result of taking the drug. Most pregnancies occur within three cycles. Side effects: The side effects of clomiphene are generally mild. They include hot flashes, blurred vision, nausea, bloating, and headache. Clomid can also cause changes in the cervical mucus, which may make it harder to tell when you're fertile and may inhibit the sperm from entering the uterus. Like many fertility drugs, Clomid can increase the chances of multiple births, although it's less likely to cause the problem than some injectable hormones. Injectable Hormones If Clomid on its own isn't successful, your doctor may recommend injectable hormones to stimulate ovulation. Some of the types are: Human Chorionic Gonadotropin (hCG), such as Pregnyl, Novarel, Ovidrel, and Profasi. This drug is usually used along with other fertility drugs to trigger the ovaries to release the mature egg or eggs. Follicle Stimulating Hormone (FSH), such as Follistim, Fertinex, Bravelle, and Gonal-F Human Menopausal Gonadotropin (hMG), such as Pergonal, Repronex, and Metrodin. This drug combines both FSH and LH. Gonadotropin Releasing Hormone (Gn-RH), such as Factrel and Lutrepulse. This hormone stimulates the release of FSH and LH from the pituitary gland. These hormones are rarely prescribed in the U.S. Gonadotropin Releasing Hormone Agonist (GnRH agonist), such as Lupron, Zoladex, and Synarel Gonadotropin Releasing Hormone Antagonist (GnRH antagonist), such as Antagon and Cetrotide Answered by Julissa Jaegers 1 year ago.

noway... you need fertiley treatment and that costs thousands of dollars Answered by Yelena Subido 1 year ago.


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