MEPRON Ressources

Application Information

This drug has been submitted to the FDA under the reference 020500/001.

Names and composition

"MEPRON" is the commercial name of a drug composed of ATOVAQUONE.

Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
020500/001 MEPRON ATOVAQUONE SUSPENSION/ORAL 750MG per 5ML
020259/001 MEPRON ATOVAQUONE TABLET/ORAL 250MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
020500/001 MEPRON ATOVAQUONE SUSPENSION/ORAL 750MG per 5ML
202960/001 ATOVAQUONE ATOVAQUONE SUSPENSION/ORAL 750MG per 5ML
207833/001 ATOVAQUONE ATOVAQUONE SUSPENSION/ORAL 750MG per 5ML
020259/001 MEPRON ATOVAQUONE TABLET/ORAL 250MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**

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Answered questions

Need advice on drinking liquid medication and Mepron?
Recently I was diagnosed with Babesiosis. My doctor prescribed Mepron in combination with another antibiotic. This drug comes in liquid form. This is the problem I’m having.Throughout my life I’ve always had a tough time swallowing liquid medication. I’ve always taken pills instead, even when I younger. Maybe... Asked by Roselle Groening 1 month ago.

Recently I was diagnosed with Babesiosis. My doctor prescribed Mepron in combination with another antibiotic. This drug comes in liquid form. This is the problem I’m having. Throughout my life I’ve always had a tough time swallowing liquid medication. I’ve always taken pills instead, even when I younger. Maybe it is just because I’m picky, but when I swallow liquid medications, in part because of the taste, it makes me feel like I’m going to gag; as a result, sometimes my stomach begins to hurt. It wouldn’t be so bad if this was treatment for a cold or something that would only last a week or so, but I will probably have to be on this medication for at least a month, taking it two times a day. Is there anyway to help this medicine go down faster? What would you do in my situation? Do you know if it is possible to get Mepron or something similar in the form of a pill? Maybe I just need to grow up, but I'm hoping there is something that can make my situation easier. Answered by Marc Pascocello 1 month ago.

Unfortunately, Mepron comes only in suspension form. You can try mixing it with applesauce or some other soft food. If your dosage is one teaspoon (that's 5mL, 750mg), it will mix easily. Remember to shake thouroughly before using. I expect that the antibiotic is azithromycin (Zithromax). This is used in combination with atovaquone (Mepron). Another combination is clindamycin with quinine sulfate capsules. Z-max & Mepron are used when clinda & quinine fail so I'd stick with what you have. Answered by Dominque Orlandi 1 month ago.


Has anyone used Mepron (atovaquone) antibiotic for chronic Lyme Disease?
Asked by Eugenie Hazlip 1 month ago.

About 10% of people infected with lyme disease (borellia burgdorferi) are also infected with babesia (babesia microti). Atovaquone plus cholestyramine were shown to be effective in people with lyme plus babesia. However, this was an open-labelled trial so it might have been biased. No double-blind placebo controlled trial (type of trial required by FDA) has been conducted so far on atovaquone use in lyme disease so it may or may not work. Discuss with your GP, or preferably with an infectious disease specialist. Answered by Tyra Burgener 1 month ago.

Some good and some poor advice here. Long term antibiotics are the best way for a person with Chronic Late stage Lyme to get well. Don't trust anyone who calls it Lymes! It is Lyme disease, named after Lyme, CT where earliest cases were diagnosed. Melton is an antimalarial used to fight babisiosis, a co infection that too often accompanies Lyme. I hope you are well now, but if you aren't, keep fighting with all you have! I am in my 30th year with Late stage Lyme, Babesiosis, and bartonellosis. When I finally get well, I may feel like a kid again...at least that was the last time I was well. Answered by Marget Camon 1 month ago.

I completely agree with Gopher - there are no trials indicating that atovaquone can be used in chronic Lyme's Disease. If you do have a diagnosis of chronic Lyme's - you should never be on _any_ long-term, chronic antibiotics unless under the supervision of an infectious disease specialist. This is a difficult condition to treat - and can often be overmedicated if the treatments are not appropriately initiated. Good luck! Answered by Irma Matonak 1 month ago.

You can look up the guidelines for treatment of Lyme disease and co-infections like babesiosis on the International Lyme and Associated Diseases Society (ILADS) website. Mepron is one of the drugs used for Babesia, a malaria-like parasite. Answered by Lamont Panozzo 1 month ago.

Mepron Antibiotic Answered by Leesa Crissinger 1 month ago.


I have to start taking mepron for Lyme's disease...Has anyone taken this and did you have any side effects?
Asked by Sau Manista 1 month ago.

I took it and didn't have any side effects. As I recall it was to treat Babesia. That's a common co-infection. It was one of the first treatments I had too. Answered by Yon Vaudrain 1 month ago.


What is the best treatment for the O.I. called P.C.P other then Mepron?
I am talking about a specific treatment for PCP that directly treats that infection alone. Asked by Shari Miyahara 1 month ago.

HAART is for HIV For pneumocystis jiroveci it's cotrimoxazole/septrin It's fungus not virus There are other causes of immunosuppression. But if it's due to HIV, then Antiviral may help. Answered by Shirleen Sehgal 1 month ago.


What are these kinds of medicines usualy taklen for?
or is there a website i can go to where it will simply let me know what these types of medications are for Asked by Ileen Crease 1 month ago.

clirithromycin- that's a type of antibiotic (mycin family vs. cillin family) ethambutol- this treats tuberculosis loperamide- just Imodium isentress- HIV1 integrase inhibitor clarithrom- antibiotic wide spectrum can be used in HIV patients mycobutin- antimycobacterial agent onpansetron- used to treat nausea/vomitting after chemotherapy mepron- antiprotazoal agent(malaria prevention) Answered by Micheal Malick 1 month ago.


How likely is it that I will become symptom free from Lyme disease?Infected for 2 years; treated for 10 months?
On heavy doses of Doxyclycline, Plaquenil, Mepron, Zithromax and tons and tons of healthy food and nutritional supplements for the past 6 months. Ready to be done, but I'm afraid that I'm just getting started. Asked by Eugenia Bucheli 1 month ago.

Hi, It all depends on how much damage the bacteria has done before it was detected and treated. Check out the wikipedia website on lyme disease, might give you some insight. NS Clinical Lab Scientist Answered by Khalilah Mckercher 1 month ago.


Does Babesiosis interfere with standard Lyme Treatment?
Ooops, I didn't know that would post twice, I just wanted to specify what "it" was, in the first sentence of my first post under "Additional Details". Asked by Hazel Orkwis 1 month ago.

BC/BS insists that I need a LP or Neuropsych evaluation to prove it or they won't pay for anything more than 4 weeks of IV ceftriaxone. The way I see it, there is no possible way I COULDN'T have it, as I was Txd with 2 wks Amoxicillin (Adult, non-pregnant). My PCP didn't know anything about Babesiosis and the 1st ID I went to said that I had received adequate Tx. His responses to my questions was "That's what they're teaching at ALL the major Universities." and "you'd LOOK much sicker". (spent 5 hrs getting reading w/breaks every 15 minutes or so.) Since BC/BS cites IDSA's guidelines, I was kind of hoping someone could tell me something that might justify their demand for subjective or possibly inaccurate & risky proof BEYOND my current ID specialist's expert clinical judgment. I guess it looks like I'm not going to get that. Answered by Felton Paquette 1 month ago.

BC/BS insists that I need a LP or Neuropsych evaluation to prove Neuroborreliosis or they won't pay for anything more than 4 weeks of IV ceftriaxone. The way I see it, there is no possible way I COULDN'T have it, as I was Txd with 2 wks Amoxicillin (Adult, non-pregnant). My PCP didn't know anything about Babesiosis and the 1st ID I went to said that I had received adequate Tx. His responses to my questions was "That's what they're teaching at ALL the major Universities." and "you'd LOOK much sicker". (spent 5 hrs getting reading w/breaks every 15 minutes or so.) Since BC/BS cites IDSA's guidelines, I was kind of hoping someone could tell me something that might justify their demand for subjective or possibly inaccurate & risky proof BEYOND my current ID specialist's expert clinical judgment. I guess it looks like I'm not going to get that. Answered by Sung Woolcock 1 month ago.

To answer the Headline (original) question... Absolutely! You really need to first address the "babs" before you take on knocking out the Lyme. All LLMDs (Lyme-lierate docs) know this. The preferred treatment for Babesia is currently Mepron (an $$$ liquid medicine that I hear tastes like paint) along with Zithromax. An antibiotic that will keep the Lyme in check can be added to a babesia-fighting drug protocol, if the doctor deams it neccessary. As far as the IDSA-recommended Lyme treatments, since these specific treatment guidelines are now to be questioned... by members of a new review group currently being chosen by the IDSA (because of, & under legal agreement With, the CT State Att'y General's office), I wouldn't take them as "gospel" right now. I think what you May be asking is whether Lyme can Progress to "Neuroborreliosis" while one is being treated for "babs". As Lyme progresses slowly (you likely have some degree of neuroborreliosis Now) & Babesia can lead to serious conditions, often very quickly- if left untreated (it is a protozoan & needs specific malarial medicines to combat- standard antibiotics won't touch it), it's best you have an LLMD guide you in the proper approach to overall treatment. Typical antibiotic treatments for Lyme are Much less effective if the body is fighting Babesiosis. This much we do know. Answered by Ray Wilfahrt 1 month ago.

I don't know the answer and I apologize for posting here, but as a side-note, I was giving blood for the first/last time and Babesiosis was one of the things we had to say yay or nay to having. I thought it sounded like something I could use being that I'm single. Turns out it's not such a good thing to have. Answered by Denyse Schwarcz 1 month ago.


What can be done to treat Lyme disease that has gone undiagnosed for years?
Is there any effective treatment after so long? Asked by Marvis Presa 1 month ago.

My Lyme took 14 years to diagnose. By that time it had completely infected my heart, nervous system and joints. Because of the advanced nature of my Lyme, my LLMD put me on IV Rocephin and IV Zithromax for about 3 1/2 years. I made a some improvement however, it was slow and incomplete. I also had Babesia and Bartonella (that went undetected until last year) so I was also put on Mepron, Artemsia, Cipro, Tindimax and Claforan at various times to fight those diseases. I have since discontinued IV antibiotics and switched to oral Doxycycline. I am making good progress however, I have had to stop treatment several times because of very severe herx reactions and/or side effects. Every doctor has their own approach to treating Late stage Lyme. Some prefer to switch drugs regularly or use a pulse method. Others tend to stick with one medication until it stops working. There is no right or wrong when it comes to which method is best because everyone's Lyme will respond differently. The only thing that is wrong it to assume that 30 days of treatment will be enough to "cure" a Lyme patient... stay away from doctors who claim that is true. The most important thing you can do is find a knowledgeable LLMD (lyme literate medical doctor) who is experienced in treating Late Stage Lyme Disease. www.ilads.org and www.lymediseaseassociation.org are very good organizations that can direct you to a specialist in your area. Never give up hope... there are always options. Sometimes patients have to use alternative methods to eradicate Lyme including, hyperbaric oxygen, RIFE machines, supplements, dietary modifications, etc. Not that I'm endorsing these types of treatments but I know of fellow patients that have used them and gotten good results. Answered by Claude Laumbach 1 month ago.

Undiagnosed Lyme Disease Answered by Francis Crader 1 month ago.

Yes there is - but even though you can treat the disease, some symptoms may not be 'curable' so you need to see a knowledgeable Infectious Disease doctor immediately, before new and possibly irreversible damage is done. Most likely you will have to have 4-6 months of IV Rocephin, possibly with another oral antibiotic at the same time. I have read in Medical Journals of people who were in such bad shape from undiagnosed Lyme that they were institutionalized but that within weeks of beginning IV antibiotics they were able to return to near normal activities. In my own case I was treated wrong, with only 10 days instead of 30 days of antibiotics called for, so the disease effects were particularly vicious, since my body produced no antibodies and the Lyme 'hid out' in my nerve linings and eventually my brain, where it went to town for 15 months until I saw an ID doctor who recognized Lyme Disease even though my blood tests were negative (because of the 10 days of antibiotics). In the end it left me with several lesions - basically little areas of 'melted' brain cells that show up on an MRI as "white matter hyperintensities". But after 4 months of IV and oral antibiotics followed by 4 months of just IV antibiotics, the Lyme was finally killed off. I'm still left with disabling cognitive deficits, severe crippling arthritis, and other symptoms though, because of the delay in finding treatment. So the answer is Yes, but get to a doctor and start treatment right away. And if you haven't already, DO NOT let anyone give you any corticosteroids like Cortisone - that is like throwing gas on a fire with Lyme Disease. Good luck, I hope you get help very soon. Answered by Lurlene Mcclory 1 month ago.

Hi, I'm new to the forum. I have had Lyme disease for 13 years (as far as I know) and did not get diagnosed until this past August. I will share with you the things I am trying but I have only had since this past summer to do any research on this, so please do as much research as you can on this topic. All these years I thought I had Fibromyalgia and tried many different healing modalities, but nothing worked. Now I have been using a Rife-Bare machine (frequency device), and plan to start an herbal protocol, as I am concerned that long term antibiotic use may make the bacteria even more resistant in the long run. I've read that there is about a third of people who use antibiotics for Lyme that later have relapses, especially those who have had Lyme for a long time. This information was from "Healing Lyme" by Stepen Harrod Buhner. However, since everyone is different, it's hard to know these things beforehand and it may not be an issue with you. In the above book I mentioned (which I am currently reading and haven't finished yet), there are herbal protocols he lists and according to the author, as of June 2008, (the book was written in 2005), he had heard from over 500 people who had used his protocol and 95% of them reported complete or significant alleviation of symptoms. I don't know yet if they were total cures, or just being symptom free. He gives the web site www.planetthrive.com to find out more about the protocol. I am going to try his protocol as soon as I finish reading the book. One must also consider the co-infections that often accompany Lyme, and these also need to be tested for and treated. I used Spirostat Technologies for my testing. Unfortunately it was expensive ($600) and not covered by insurance. That lab looks for at least thirty bacterial species (Lyme ones and the co-infections) and I believe they looked for the DNA of the bacteria. If you see a MD, try to find one that is Lyme Literate. They are few and far between, but you can find one through the Lyme Disease association web site. Once I start treatment, I'll post more. I wish you the best. Take care, Vicki Answered by Alecia Bogue 1 month ago.

I've had Lyme disease undiagnosed for 20 years. Taking the herbal approach. Teasel Root seems to work miracles given that it gets past the blood brain barrier and causes a Hertz reaction all over my body indicating a dying off of the bacteria. Also, would recommend Lymeout formula and rhodiola rosea. Answered by Zenobia Hewes 1 month ago.


Nobody can figure out what's happening to my sister's health. Suggestions?
My 43yo sister's health has been steadily declining over the past 5 years. She was initially diagnosed with advanced Lyme disease. She also received a Lyme vaccine prior that has since been pulled from the market. She now has an autoimmune problem, has severe disc degeneration (8 herniated discs and no disc in... Asked by Devora Kowalke 1 month ago.

My 43yo sister's health has been steadily declining over the past 5 years. She was initially diagnosed with advanced Lyme disease. She also received a Lyme vaccine prior that has since been pulled from the market. She now has an autoimmune problem, has severe disc degeneration (8 herniated discs and no disc in one cervical location). She has severe pain, taking serious pain meds, losing weight rapidly because food makes her feel worse with hypertensive episodes. She sleeps most days and now looks gaunt. I feel she's dying a slow death because doctors readily admit the are puzzled and not sure what to do for her. Is there any kind of a facility where a team of doctors and nutritionists try to work together to figure out puzzling medication conditions like this when other doctors are giving up? Answered by Kathryne Merriott 1 month ago.

If doctors are saying she "had" Lyme disease but no longer does, they are of the IDSA school that believes Lyme is easily cured. The people who believe Lyme can be chronic, elusive, and challenging to treat are at ILADS, International Lyme and Associated Diseases Society. Go to their website and look for treatment guidelines. Read. Seek an ILADS-Lyme specialist for open-minded consideration of Lyme as a possibility. She may have more than one thing going on, but if Lyme is part of the mix, it makes sense to address it. Answered by Nicki Hanly 1 month ago.

There are doctors involved in research but we would need to know your location and how far she can travel. It sounds like some sort of bone necrossis, and there are several autoimmune or blood disorders that could cause that. My Mother has Hyperhomocyistenemia and I have Antiphosphlipid Syndrome. Both can be causes of Necrossis. There are probably others I am giving you a link to a page that can help explain a little of this. Answered by Sonya Mikkelson 1 month ago.

day one million = x which will also be any quantity day two = x + 7 day three = day two + 7 = x + 7 + 7 day four = day three + 7 = x + 7 + 7 + 7 day five = x + 7+7+7+7 and you already know the puppy at a hundred twenty five sizzling puppies a hundred twenty five = day one million + day two + ... + day five a hundred twenty five = (x) +( x + 7) +( x + 7 + 7) +... every day has one million x and there are five days so there are five x's a hundred twenty five = 5x + 7 + 7 + 7... now determine what number of 7's (you'll simply depend them or use this process): day two has one 7, day three has 2 7's... so there are one million + two + three + four = 10 sevens a hundred twenty five = 5x + 10(7) a hundred twenty five -70 = 5x fifty five = 5x fifty five/five = x eleven = x So day one million = eleven puppies day two = 18 puppies day three = 25 puppies day four = 32 puppies day five = 39 puppies eleven + 18 +25+32 + 39 = a hundred twenty five Answered by Loreta Wojtas 1 month ago.

I am praying for an answer for you & your sister, and that she will be blessed with a miracle. May God's peace be with you both. In his name... Answered by Bridgette Cezar 1 month ago.


These Spasms Are off and on all day?
I had really bad ulcers all through my life, had a dilation done, scopes. I been on medications and tried them all. I'm HIV+ on Complera, Megace, Mepron and Gabapentin. I been having these sharp dull stabbing pains in my chest, side, back and up through my face head and eyes. It's so painful that I'm... Asked by Donnell Bottoni 1 month ago.

I had really bad ulcers all through my life, had a dilation done, scopes. I been on medications and tried them all. I'm HIV+ on Complera, Megace, Mepron and Gabapentin. I been having these sharp dull stabbing pains in my chest, side, back and up through my face head and eyes. It's so painful that I'm freaking out and getting heat flashes and afraid I have a heart problem but they do blood wortk all the time and had an ultra sound not to long ago. Just wondering if this is the case Answered by Tiffanie Bloomer 1 month ago.

Might be, but these are questions you better ask your doctor and he can give you the appropriate answers for sure.. Answered by Robt Boyance 1 month ago.


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