MENADIONE Ressources

Application Information

This drug has been submitted to the FDA under the reference 002139/003.

Names and composition

"MENADIONE" is the commercial name of a drug composed of MENADIONE.

Answered questions

Is menadione (vitamine K3) harmful for pets?
Firstly, my apologises for my english, I live in Brazil and my native language is the Portuguese.I use ProPlan Puppy Large Breed for my 6 months old GSD. ProPlan contains menadione (vitaminte K3) listed as ingredient and I am quite worried since I heard it may be toxic in pets. Is that really true?I would... Asked by Eileen Rosberg 3 months ago.

Firstly, my apologises for my english, I live in Brazil and my native language is the Portuguese. I use ProPlan Puppy Large Breed for my 6 months old GSD. ProPlan contains menadione (vitaminte K3) listed as ingredient and I am quite worried since I heard it may be toxic in pets. Is that really true? I would prefer organic pet foods, but unfortunately they are not availabe for sale in Brazil. Answered by Jeanne Colasante 3 months ago.

Menadione, also known as vitamin K3, is a synthetic version of vitamin K. The natural occuring compounds are vitamin K1 (Phylloquinone, from plant sources) and Vitamin K2 (Menaquinone, synthesized by bacteria in the digestive tract and absorbed by the body). Technically menadione isn't even a vitamin, but a precursor that is converted in the body after ingestion. Natural vitamin K is fat soluble, while menadione derivatives (pure menadione can not be processed) are water soluble and bypass the natural pathway of utilization by the body. Menadione is added as an inexpensive vitamin K supplement in commercial foods. The common statement as to why it is added is "to help with blood clotting", yet it is scientifically proven that the effectivity of menadione on blood clotting is inferior. Even veterinarians will administer vitamin K1 as an antidote to dogs who have for example ingested rat poison, which causes internal bleeding. Manufacturers who use menadione in their products also like to claim that it is "more stable" than natural vitamin K and has "more nutritional value". Not a single one of them has acknowledged the scientifically proven side effects of this substance. Why is it bad? Here is a list of negative effects of menadione on the body. * causes cytotoxicity in liver cells * causes formation of radicals from enzymes of leucocytes, with the consequence of cytotoxic reactions * considerably weakens the immune system * possible mutagenic effects * damages the natural vitamin K cycle * has no effect on coumarin derivatives, which are often present in commercial food due to mold contamination (toxic when ingested) * causes hemolytic anemia and hyperbilirubinemia, not just linked to large doses * disturbs the level of calcium ions (Ca2+) in the body, which is an important factor fibrinolysis * is directly toxic in high doses (vomiting, albuminuria), unlike natural vitamin K * builds up in tissue and has been detected in eggs, meat and milk of animals supplemented with menadione derivatives * causes irritation of skin and mucous membranes * causes allergic reactions and eczema Menadione (e.g. menadione sodium bisulfate, menadione sodium bisulfite or menadione dimethylpyrimidinol bisulfite) * has never been researched or specifically approved for long term use, such as in pet food * has been banned from use in food and supplements for human use in many European countries due to serious side effects, including permanent damage and deaths * FDA has banned synthetic vitamin K from over-the-counter supplements because of its high toxicity * vitamins K1 and K2 are metabolized through the lymphatic system, utilizing pancreatic enzymes and bile acids and regulated by the liver. Vitamin K3 is absorbed directly and bypasses the natural pathways and regulators. Answered by Reva Vear 3 months ago.

Vitamine K3 Answered by Warren Bantz 3 months ago.

Actually if it's prescribed by a vet, it's fine. My parents dog got into rat poison and had Vitamin K. Pretty pricey. Answered by Lolita Patuel 3 months ago.

Pro Plan is a good food. Your dog will be just fine. And btw your english is excellent. Next if you really want to feed your dog organic food then may I suggest you try ordering it online and have it shipped to you. Good luck!!! Answered by Luigi Payno 3 months ago.

Your English is excellent. ProPlan seems to be fine. Below is a resource for organic pet food. Good luck. Answered by Easter Genzel 3 months ago.

Your english is just fine. If it is in the dog food then it should be just fine. We have had a lot of problems with some dog foods here in America but the brand that you are feeding your dog is just fine. I would not worry and keep feeding it to your dog with out worries. Have a great day! Answered by Hwa Honeysucker 3 months ago.


Is menadione bad for dogs?
I heard its bad for them, yet some say its good. On my dogs food ingredient list it says "menadione sodium bisulfate complex(source of vitamin k activity)" If itsbad what will it do to her? Thanks xx Asked by Shante Kela 3 months ago.

have to ask vet i have no idea what that is where on list? depends on quantity i would guess Answered by Taunya Martinis 3 months ago.


Should I worry about the menadione in my puppy's dog food?
I just started her on Rachael Ray's Nutrish Dog Food, and I only noticed that menadione was a small ingredient after I bought the big bag. She hasn't quite phased into the dog food yet, but I don't know if I should just go ahead and have her finish the dog food, or get a different dog food anyways. Keep... Asked by Madison Destree 3 months ago.

I just started her on Rachael Ray's Nutrish Dog Food, and I only noticed that menadione was a small ingredient after I bought the big bag. She hasn't quite phased into the dog food yet, but I don't know if I should just go ahead and have her finish the dog food, or get a different dog food anyways. Keep in mind that I can't buy those really high quality foods because I just don't have the money and I can't drive to the stores where they are. I read that while menadione could be toxic, the amount of menadione in the dog food wasn't large enough to be a problem. I'm still worried that it could hurt her, though. Answered by Marlo Tanis 3 months ago.

Hello Paw S There is concern for this synthetic vitamin (K3) whilst K1 and K2 are fine. I understand you do not want to waste money (who does?!) and the concerns would be for long term feeding of Menadione and the "build up" that can occur. Why not buy another product and use that as the main component along with some of the Rachel Ray's until it is all used up - reducing the risk would be achieved. Have a look at a great website dog food aid for other feeding options - the website is very comprehensive in suggesting different food styles. I'll put a link below for you. Hope this has helped and good luck Answered by Romaine Ovalle 3 months ago.

Low dose menadione is still used as an inexpensive micronutrient for livestock in many countries. Forms of menadione are also included in some pet foods in developed countries as a source of vitamin K. I doubt you have anything to worry about. Answered by Maxima Nelsen 3 months ago.


Is there any cockatiel diet that does not use menadione?
I know menadione/sodium bisulfate complex/dimethylpyrimidinol bisulfate is fake vitamin K and linked to health issues. I have looked online and in stores and can't seem to find a single bird/cockatiel (seed or pellet) food/diet that does NOT contain fake vitamin K; even the higher quality and supposed "premium"... Asked by Dakota Rieser 3 months ago.

I know menadione/sodium bisulfate complex/dimethylpyrimidinol bisulfate is fake vitamin K and linked to health issues. I have looked online and in stores and can't seem to find a single bird/cockatiel (seed or pellet) food/diet that does NOT contain fake vitamin K; even the higher quality and supposed "premium" diets do. Does anyone know of a cockatiel/medium hookbill diet that doesn't contain this? Thanks! Answered by Yuri Silguero 3 months ago.

We feed our birds (a cockatiel and a budgie) the Hagen brand Budgie "original blend" seed mix. It's the same as the Hagen Cockatiel mix except it does not contain the sunflower seeds which we buy separately in bulk and then add to the cockatiels seeds. This mix does contain a lot of added vitamins and minerals but it does not appear to contain the vitamin K you refer to in your question. Just out of curiosity, what is your concern about vitamin K? Also, you should know that your cockatiel will eat a lot of healthy human foods that are really good for him/her like apple, corn, beans, rice, berries, hemp seeds etc. They especially love string beans which are in season right now. Cheese is a favorite too. They also love multigrain bread and oatmeal. If you supplement their diet with tasty human food they will get a lot more vitamins than what's in the prepared seed mixes. And they'll be happier too, especially if you give them play time outside the cage along with the treats... Answered by Joanne Boerstler 3 months ago.

I don't know about the pellets in the cockatiel food. Sounds a bit strange. Only feed your bird good quality seed that doesn't have too many sunflower seeds in it. Your tiel will get used to the new seed. Also put small sections of uncooked corn on the cob in his cage for him to eat. He will love it. Snow pea sprouts are also a favourite for cockatiels. Your bird really should have a mixed diet of fresh food as well as seed. Answered by Loni Kosbab 3 months ago.


Knowing the dangers of Menadione?
WHY do you still incorporate this liver damaging substance into your dog and cat foods??? I would REALLY like to know this. There is no known reason for any type of Vitamin k usage for dogs or cats and when Vets feel the need they use a Natural form as in K1 or K2. While I applaude the dis use of animal by products... Asked by Eli Lacio 3 months ago.

WHY do you still incorporate this liver damaging substance into your dog and cat foods??? I would REALLY like to know this. There is no known reason for any type of Vitamin k usage for dogs or cats and when Vets feel the need they use a Natural form as in K1 or K2. While I applaude the dis use of animal by products the fact remains that Menadione causes severe problems in animals and while AFFCO may feel it is safe for poulty or swine there is no comparrison to canines or felines. Since other reputable companies have removed this product Purina continues to use it and I would like to know why. I am sure I am not alone in this query. Thank you for the opportunity to ask this question. Answered by Sherie Nuriddin 3 months ago.


Is menadione sulphate toxic for parrots?
Some pet food companies that make organic pellets for parrots claims "Menadione sulphate - present in practically every parrot food brand - is toxic for parrots". I am confused because menadione is K vitamin, isn't it? Is this true? How does the menadione sulphate exerts its toxic effect in parrots? Asked by Adena Venzke 3 months ago.

I have never heard anything about this subject one way or the other. If I was in your shoes, I would ask a veterinarian or a vet school. I do not know if any of them have a website or not. I would type veterinarian into the search box and see if anything comes up that looks promising. Answered by Ara Carbonaro 3 months ago.


Is Menadione really dangerous for cats?
I've seen this in some cat foods and people say to avoid it. Is there any scientific proof for that? Asked by Sage Dehler 3 months ago.

would avoild incase Answered by Suzette Mengle 3 months ago.


Anybody know anything about the Menadione ingredient in pet foods?
The food I feed my kitten has it in it, any ideas what food to feed him that doesn't have it? Asked by Nichole Oder 3 months ago.

The Menadione is a synthetic vitamin K supplement and it's been linked to health problems. High end pet foods do not have it included. Here are some good high quality foods that don't have it: Innova, Wellness, Felidae, Solid Gold, Natural Balance. Answered by Jayna Dauenhauer 3 months ago.


Why is Menadione Bisodium sulfate(cheap form of vitamin k) bad for dogs?
Asked by Gigi Jungers 3 months ago.

It makes the body form clots in the blood, which can lead to a wide variety of problems for your pet. Answered by Fred Dost 3 months ago.


I have a 4 month old kitten I have him on Nutro Indoor Kitten I want to switch caues of the Menadione any idea
Does anyone know if Welness has menadione? This is a bad thing to have in food? Asked by Etsuko Liccketto 3 months ago.

I have used Purina Kitten Chow for all 5 of my cats, and moved them to regular Purina Cat Chow and they all have beautiful coats and are healthy, well sized cats. Everyone who comes over and meets my cats says that they are the softest, shiny-est cats they have ever seen! I love them and pet them and feed them Purina Cat Chow, and it seems to do the trick! I don't think that the more expensive foods are better than Purina. It's always a great price, it's easy to find at any store and it seems to keep mine healthy and happy, so Purina is what I recommend. (I so sound like a Purina worker or something, but I just really like it!) Answered by Carmine Forgrave 3 months ago.

Wellness Kitten is the perfect choice. It is from a good meat source and contains wholesome ingredients. Be careful when you purchase and make sure the store you are buying from doesn't carry the old Wellness formula that still has garlic in them. Also, no, Wellness does not contain Menadione. Also, if you are concern about Menadione, you should also know that sometimes, it is listed in the ingredients as Vitamin K supplement. Answered by Ka Matyi 3 months ago.

Wellness is a very good food. Blue Spa....not as good. I'm not familiar with it but it's not on my list of good foods. Go with the Wellness. Canned will be better and may help a bit with shedding. Not a lot mind you, but it's healthier anyway. EDIT: Wellness doesn't contain Menadione. Answered by Elfreda Munerlyn 3 months ago.

Wellness is really good. I use Innova for my dog and cat and always get compliments on their coat. I am not a fan of Nurtro. If I had to switch for some reason I would consider Welness. I worked at a natural pet food store for over a year. Answered by Verla Nakai 3 months ago.


Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
002139/003 MENADIONE MENADIONE TABLET/ORAL 5MG

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
002139/003 MENADIONE MENADIONE TABLET/ORAL 5MG

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