Application Information

This drug has been submitted to the FDA under the reference 011961/001.

Names and composition

"MARPLAN" is the commercial name of a drug composed of ISOCARBOXAZID.

Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
011961/001 MARPLAN ISOCARBOXAZID TABLET/ORAL 10MG

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
011961/001 MARPLAN ISOCARBOXAZID TABLET/ORAL 10MG

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Answered questions

Looking for information about an MAOi medication called Marplan?
A friend of mine is currently taking an MAOi called "Parnate" every so often she goes through depression, and it seems as if Parnate is not enough or simply does not work. Her doctor wants to move her to Marplan. I would like to know if anyone is on there or has any good information pertaining to it. I of... Asked by Nobuko Medicus 1 year ago.

A friend of mine is currently taking an MAOi called "Parnate" every so often she goes through depression, and it seems as if Parnate is not enough or simply does not work. Her doctor wants to move her to Marplan. I would like to know if anyone is on there or has any good information pertaining to it. I of course will look this up and ask the doctor a lot more about it. I just would like to get opinions on people who are or may have taken it at one time. Thank you in advance. Answered by Lourdes Rhymes 1 year ago.

Marplan is used for treatment resistant depression, although I would question its use in the case of someone going through depression every so often. It is usually used in chronic major depression, not for someone going through depressive episodes intermittently in my experience. It is often less desireable than many other antidepressants because it often requires from 2-4 doses per day, as opposed to many others that are a single dose daily. Given that the depression is periodical for your friend, it is important that bipolar is not a consideration in diagnosis as it is not suitable for those with bipolar (risk of increasing manic/depressive episodes). It is not a drug that I personally would be willing to take unless all other alternatives have been tried. I would also be interested to know why her dr has gone down the road of MAOi's as the side effects & contraindication of these drugs are often a lot more severe than with the SSRI's. Is it is psychiatrist who is prescribes her medication or a general dr - if not a psychiatrist I would be wanting to see a psychiatrist Answered by Edgardo Goodard 1 year ago.

Then why are you right here, quite of a scientific drug information superhighway internet site, like WebMD, the Mayo medical institution or googling the call? you're actually not very possibly to get useful, solid techniques right here. Answered by Leon Maisonet 1 year ago.


Anyone try Marplan (MAOI)?
I know that this drug is a last resort med. I've been on almost every "modern" antidepressant there is and they haven't helped. I am desperate(sp?) for something that will work. Asked by Micheal Vliem 1 year ago.

this is a dangerous drug and should only be used virtually as a last resort. it has a number of side affects apart from anything else. talk it over with your doctor. google 'marplan drug' and you will see how dangerous it is. Answered by Miguel Straughan 1 year ago.


What happens if I mix Zoloft with an MAO like Marplan, Nardil, and Parnate?
I need to know because I'm not really sure If I mixed the two or not. Asked by Hiram Hanney 1 year ago.

combo can increase your risk for serotoin syndrome. please do some research. Answered by Vashti Pelkey 1 year ago.


Is MAO inhibitor the most dangerous prescribing drug alive, worst than heroin?
monoamine oxidase inhibitor is a drug given for mood disorders such as depression etc. It is also a drug given for parkinsons disease. however, this drug is last when almost all medications for mood doesn't work, even tricyclics. My friend is taking insocarboxazaid, known as Marplan (MAO inhibitor) and she cannot... Asked by Clarence Langelier 1 year ago.

Heroin's not a prescription drug firstly. The older generation of MAO inhibitors do have side effects with tyramine (cheese, wine containing foods and a whole lot of others) and can cause hypertensive crises (though not in 5 minutes as you alluded to as far as I know). The newer forms of MAO inhibitors tend to have less of a dietary interaction but they're still not usually prescribed. Why is your friend taking Marplan? is it for a mood disorder? It's surprising that she isn't started on the more common classes of mood disorder medications like SSRIs (prozac, celexa..etc.) A lot of drugs are dangerous - yes MAO inhibitors are bad with dietary reactions but no drug is perfectly safe. Answered by Cassi Cabral 1 year ago.

ALL antidepressants have side-effects! Foods with "tyramine" It's an older antidepressant, it came out in 1959. The original manufacturer stopped making it in 1994. "A randomized controlled trial published in December 1988 found that isocarboxazid significantly reduced binging and purging in bulimia nervosa, regardless of the presence or absence of depression or personality disorder." With today's new medications it's really a last resort. > "Does anyone disagree, b/c it MAO inhibitor seems extremely dangerous. " Even the tricyclics will elevate blood pressure, and other side effects. To be chemically and clinically depressed, life literally stops. Trust me, the precautions your friend puts up is small compared to being severely depressed. As long as she's being monitored closely by a physician she should be ok. It's better she's taking this under a doctor's care rather than "self-medicating". You really can't compare it to taking heroin. Having said this, she should continue to investigate newer medications or combination of meds. Answered by Gerald Netolicky 1 year ago.

MAOIs aren't dangerous, they just have a lot of dangerous interactions. And because you're clearly ignorant of the reality, I'll point out that your friend won't just drop dead if she eats something that's not approved. The possible side effects are myriad and many of them are life threatening, but some of them are more innocuous like sweating. It goes without saying that if your friend feels she'd be better off without the drug then she should discontinue its use. Answered by Viva Dohm 1 year ago.


What can a person who is dependent on MAOI take to help with sleep?
Please answer if you have taken the following medications Parnate Nardil Marplan Thank you... Asked by Willette Scala 1 year ago.

Those are some very serious drugs - if you are taking those, you already know you need to consult your md and psychiatrist and also the pharmacist before you put anything else in your mouth. Surely you know better than to ask non professionals about taking OTC medications with the stuff you have mentioned. Answered by Delbert Bella 1 year ago.


Are there drugs im not suppose to take with adderall?
i have the 30 mg pills is that safe? how many shud i take and how long does the effect last Asked by Twanda Bounleut 1 year ago.

well aside from the whole ethical perspective, i got a hold of sum adderall to help me focus when im studying. i know many people here will bomb me with criticism but i go to the best university in the country and if this is what it takes then please bare with me. my only concern is, is there a drug i shouldn't be taking since it may contradict each other and end bad for me? currently i am also on accutane to control my acne. your answers are greatly appreciated so thanks Answered by Yahaira Klingbeil 1 year ago.

MAO inhibitors such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or selegiline (Eldepryl, Emsam) within the past 14 days before you take an Adderall can cause life-threatening side effects. not contradicting that i know of, but can end badly. a single 30mg would be sufficient for the day and would be totally safe (i have friends who are prescribed multiple 20mgs a day). i take a 20mg every morning (im 6'3" 190lbs and have absolutely no attention span) and the focusing lasts for about 12 hours and it can keep me awake and alert for about 17 hours. Answered by Ewa Castillero 1 year ago.


Monoamine oxidase inhibits what?
Asked by Luna Whitton 1 year ago.

Monoamine oxidase (MAO) oxidizes the monoamine neurotransmitters. I'm sure that really clarifies things, right? Monoamine neurotransmitters are a class of neurotransmitters that includes the catecholamines (dopamine, norepinephrine, epinephrine), serotonin, and several others. When they're oxidized by MAO, they no longer function. So MAO inhibits the function of several neurotransmitters, including dopamine, serotonin, norepinephrine, and epinephrine. MAO inhibitors are a class of anitdepressants that work by inhibiting the function of MAO (i.e. preventing it from inhibiting the monoamine neurotransmitters). Although this would have an effect on all monoamine neurotransmitters, it's primarily dopamine and serotonin that are tranditionally considered to be the monoamines involved in depression (although some newer antidepressant focus on norephinephrine). Answered by Cathi Krapp 1 year ago.

these are old school anti depressants that were used when anxiety was also present not used too much any more because of the many restrictions that go along with them Answered by Wade More 1 year ago.


I m taking flouxetine for depression since one year are there any side effects using this medication?
Asked by Lorraine Mildenhall 1 year ago.

What is the most important information I should know about fluoxetine? Do not take fluoxetine together with pimozide (Orap), thioridazine (Mellaril), or a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate). You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Fluoxetine is the only antidepressant that is FDA-approved for use in children with depression. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment. Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. SSRI antidepressants may cause serious or life-threatening lung problems in newborn babies whose mothers take the medication during pregnancy. However, you may have a relapse of depression if you stop taking your antidepressant during pregnancy. If you are planning a pregnancy, or if you become pregnant while taking fluoxetine, do not stop taking the medication without first talking to your doctor. What should I discuss with my healthcare provider before taking fluoxetine? Do not use fluoxetine if you are using any of the following drugs: pimozide (Orap); thioridazine (Mellaril); or an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or selegiline (Eldepryl, Emsam). Serious and sometimes fatal reactions can occur when these medicines are taken with fluoxetine. You must wait at least 14 days after stopping an MAO inhibitor before you can take fluoxetine. You must wait 5 weeks after stopping fluoxetine before you can take thioridazine (Mellaril) or an MAOI. Before taking fluoxetine, tell your doctor if you are allergic to any drugs, or if you have: cirrhosis of the liver; kidney disease; diabetes; seizures or epilepsy; bipolar disorder (manic depression); or a history of drug abuse or suicidal thoughts. If you have any of these conditions, you may not be able to use fluoxetine, or you may need a dosage adjustment or special tests. You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment. FDA pregnancy category C. SSRI antidepressants may cause serious or life-threatening lung problems in newborn babies whose mothers take the medication during pregnancy. However, you may have a relapse of depression if you stop taking your antidepressant during pregnancy. If you are planning a pregnancy, or if you become pregnant while taking fluoxetine, do not stop taking the medication without first talking to your doctor. Fluoxetine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give fluoxetine to anyone younger than 18 years old without a doctor's advice. Fluoxetine is the only antidepressant that is FDA-approved for use in children with depression. How should I take fluoxetine? Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results from the medication. Do not break, chew, or open an extended-release capsule. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking the pill would cause too much of the drug to be released at one time. Measure the liquid form of fluoxetine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one. It may take 4 weeks or longer before you start feeling better. Do not stop using fluoxetine without first talking to your doctor. You may have unpleasant side effects if you stop taking this medication suddenly. To treat premenstrual dysphoric disorder, the usual dose of fluoxetine is once daily while you are having your period, or 14 days before you expect your period to start. Follow your doctor's instructions. Store fluoxetine at room temperature away from moisture and heat. What happens if I miss a dose? Take the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take extra medicine to make up the missed dose. If you miss a dose of Prozac Weekly, take the missed dose as soon as you remember and take the next dose 7 days later. However, if it is almost time for the next regularly scheduled weekly dose, skip the missed dose and take the next one as directed.Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention if you think you have taken too much of this medication. Symptoms of a fluoxetine overdose may include nausea, vomiting, fever, sleepiness, rapid or uneven heartbeat, confusion, fainting, seizures, or coma. What should I avoid while taking fluoxetine? Avoid drinking alcohol, which can increase some of the side effects of fluoxetine. Avoid using other medicines that make you sleepy (such as cold medicine, pain medication, muscle relaxers, medicine for seizures, other medication for depression or anxiety). They can add to sleepiness caused by fluoxetine. Cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by fluoxetine. Tell your doctor if you regularly use any of these other medicines. Fluoxetine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Fluoxetine side effects Get emergency medical help if you have any of these signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. Call your doctor at once if you have any of these serious side effects: seizure (convulsions); tremors, shivering, muscle stiffness or twitching; a red, blistering, peeling skin rash; problems with balance or coordination; or agitation, confusion, sweating, fast heartbeat. Less serious side effects may include: drowsiness, dizziness, weakness; runny nose, sore throat, headache, flu symptoms; nausea, diarrhea, changes in appetite; weight changes; decreased sex drive, impotence, or difficulty having an orgasm; or dry mouth, increased sweating. This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. Answered by Casimira Vasek 1 year ago.

Yes. Talk to prescriber. Read package insert. Google the med. Ambivalence is one symptom of depression. Since MD is prescribing, hopefully a shrink, then why not ask that person your concerns. Answered by Jamal Brasuell 1 year ago.

If you mean long-term effects, I found this on wikipedia: SSRIs such as fluoxetine have been associated with tardive dyskinesia and akathisia, among other extrapyramidal symptoms more commonly associated with antipsychotics. Answered by Alyse Giegerich 1 year ago.

u should know, uve been takin it for one year. always research medicine and its side effects before u take it.. especially for a year straight and THEN question it! thats COMMON SENSE. Answered by Damion Fulker 1 year ago.

Acid stomach.ت❭❥ Answered by Vinnie Floch 1 year ago.


Does adderal hurt yout health?
im prescribed adderal and i dont overdose will it ever cathc up to me later on? Asked by Angela Ohmen 1 year ago.

Do not use Adderall if you have used an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or selegiline (Eldepryl, Emsam) within the past 14 days. Serious, life-threatening side effects can occur if you take Adderall before the MAO inhibitor has cleared from your body. Do not use this medication if you are allergic to Adderall, or if you have hardened arteries (arteriosclerosis), heart disease, moderate to severe high blood pressure (hypertension), overactive thyroid, glaucoma, severe anxiety or agitation, or a history of drug or alcohol addiction. Some stimulants have caused sudden death in children and adolescents with serious heart problems or congenital heart defects. Before taking Adderall, tell your doctor if you have any type of heart problems. Do not give this medication to a child younger than 3 years old without the advice of a doctor. Long-term use of Adderall can slow a child's growth. Tell your doctor if the child using this medication is not growing or gaining weight properly. Adderall is a drug of abuse and may be habit-forming. Keep track of how many pills have been used from each new bottle of this medicine. You should be aware if any person in the household is using this medicine improperly or without a prescription. Using this medication improperly can cause death or serious side effects on the heart Answered by Ching Maciejewski 1 year ago.

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