Application Information

This drug has been submitted to the FDA under the reference 019010/001.

Names and composition

"LUPRON" is the commercial name of a drug composed of LEUPROLIDE ACETATE.

Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
019010/001 LUPRON LEUPROLIDE ACETATE INJECTABLE/INJECTION 1MG per 0.2ML
019943/002 LUPRON LEUPROLIDE ACETATE INJECTABLE/ INJECTION 3.75MG

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
019010/001 LUPRON LEUPROLIDE ACETATE INJECTABLE/INJECTION 1MG per 0.2ML
019732/001 LUPRON DEPOT LEUPROLIDE ACETATE INJECTABLE/INJECTION 7.5MG per VIAL
019943/002 LUPRON LEUPROLIDE ACETATE INJECTABLE/ INJECTION 3.75MG
020011/001 LUPRON DEPOT LEUPROLIDE ACETATE INJECTABLE/INJECTION 3.75MG per VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
020011/002 LUPRON DEPOT LEUPROLIDE ACETATE INJECTABLE/INJECTION 3.75MG
020263/002 LUPRON DEPOT-PED LEUPROLIDE ACETATE INJECTABLE/INJECTION 7.5MG per VIAL
020263/003 LUPRON DEPOT-PED LEUPROLIDE ACETATE INJECTABLE/INJECTION 3.75MG per VIAL,7.5MG per VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
020263/004 LUPRON DEPOT-PED LEUPROLIDE ACETATE INJECTABLE/INJECTION 7.5MG per VIAL,7.5MG per VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
020263/005 LUPRON DEPOT-PED LEUPROLIDE ACETATE INJECTABLE/INJECTION 11.25MG per VIAL
020263/006 LUPRON DEPOT-PED LEUPROLIDE ACETATE INJECTABLE/INJECTION 15MG per VIAL
020263/007 LUPRON DEPOT-PED LEUPROLIDE ACETATE INJECTABLE/INJECTION 11.25MG per VIAL
020263/008 LUPRON DEPOT-PED LEUPROLIDE ACETATE INJECTABLE/INJECTION 30MG per VIAL
020517/001 LUPRON DEPOT LEUPROLIDE ACETATE INJECTABLE/INJECTION 22.5MG per VIAL
020517/002 LUPRON DEPOT LEUPROLIDE ACETATE INJECTABLE/INJECTION 30MG per VIAL
020517/003 LUPRON DEPOT LEUPROLIDE ACETATE INJECTABLE/INJECTION 45MG per VIAL
020708/001 LUPRON DEPOT LEUPROLIDE ACETATE INJECTABLE/INJECTION 11.25MG per VIAL
021088/001 VIADUR LEUPROLIDE ACETATE IMPLANT/IMPLANTATION EQ 65MG BASE
021343/001 ELIGARD LEUPROLIDE ACETATE INJECTABLE/SUBCUTANEOUS 7.5MG per VIAL
021379/001 ELIGARD LEUPROLIDE ACETATE INJECTABLE/SUBCUTANEOUS 22.5MG per VIAL
021488/001 ELIGARD LEUPROLIDE ACETATE INJECTABLE/SUBCUTANEOUS 30MG per VIAL
021731/001 ELIGARD LEUPROLIDE ACETATE INJECTABLE/SUBCUTANEOUS 45MG per VIAL
074728/001 LEUPROLIDE ACETATE LEUPROLIDE ACETATE INJECTABLE/INJECTION 1MG per 0.2ML
075471/001 LEUPROLIDE ACETATE LEUPROLIDE ACETATE INJECTABLE/INJECTION 1MG per 0.2ML
075721/001 LEUPROLIDE ACETATE LEUPROLIDE ACETATE INJECTABLE/INJECTION 1MG per 0.2ML
078885/001 LEUPROLIDE ACETATE LEUPROLIDE ACETATE INJECTABLE/INJECTION 1MG per 0.2ML

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Answered questions

Lupron depot?
complcations with long use?i haveon this for almost 9 years Asked by Kimberlie Messer 1 year ago.

I was on it about 13 years ago. I didn't have any problems with it other than it shut down my cycles for those 6 months. You'll be fine. After those, you should consider Seasonale birth control. I've been on that for the last 2 years for my endometriosis. Before that I was on the depo provera shots for 9 years Answered by Eulalia Mildenhall 1 year ago.


Has anyone with endometriosis had a good experience with Lupron?
I have had two laparoscopies in the past three years and I'm having pain again. The doctor suggested this instead since I don't want to get pregnant right now. Any input would be great! Thanks. Asked by Erminia Lorance 1 year ago.

Worst drug I have ever taken. I would never recommend it for anyone. I had such horrible side effects and I only took it for 3 months. Look at Endo's post above for the side effects. That's a pretty good list of what I went through for 3 months. I lost 16 pounds over that time and had one headache that never went away. If possible find another way. This isn't good. There are also other GnRH agonists out there - Synarel (nasal spray) and Zolodex (subcutaneous implant). The implant is supposed to be painful. If you have to go this route maybe Synarel is better because it is a daily nasal spray and you can stop it if you have problems. Lupron is a depot injection. Once in it can't be taken out. If you have problems you are screwed for about a month! Answered by Lacie Buechel 1 year ago.

I had a terrible experience with Lupron. It gave me considerable pain in my hip and other problems. At one point, I could barely walk! Another friend of mine had similar problems. I would avoid it. Answered by Mirtha Komsthoeft 1 year ago.


What are your experiences with depot lupron?
I have had horrible side effects from the Depot Lupron shot (3-months doasage), now I am not talking about depot provera, this is a stronger shot to treat endometriosis. It has helped with the pain and lessened the growths, but I have bad hot flashes, weight gain, dryness, the list goes on. Anyone have better... Asked by Alline Sculley 1 year ago.

I have had horrible side effects from the Depot Lupron shot (3-months doasage), now I am not talking about depot provera, this is a stronger shot to treat endometriosis. It has helped with the pain and lessened the growths, but I have bad hot flashes, weight gain, dryness, the list goes on. Anyone have better experience with it? Can anyone suggest an alternative treatment?? BCPs don't work, i tried them already. Answered by Rene Phyfiher 1 year ago.

Stay FAR away from Lupron!!!!! Endo is an estrogen dominance disease. You need to replace the progesterone that your body is missing with a NATURAL PROGESTERONE CREAM! Email me and I can tell you more. This is some very nasty stuff. :( Here is an article I found.... Be Careful of Lupron for Endometriosis, It Could Be the Kiss of Death By Nicholas Regush This particular saga began a decade ago with an injection of a powerful prescription drug called Lupron. Lynne Millican took the shot for endometriosis, a condition in which pieces of the lining of the uterus are found in other parts of the body, especially in the pelvic cavity. Ten years later, Millican believes she is still suffering from the effects of that injection. Her many symptoms have included the development of a noncancerous tumor, breast cysts, cardiac arrythmias, dizziness, swelling and fatigue. Millican is a registered nurse (and paralegal) living in the Boston area who has become deeply involved in a grass-roots movement to force the U.S. Food and Drug Administration (FDA), and Members of Congress to take a close look at Lupron. The FDA first approved Lupron in 1985 for treatment of men with advanced prostate cancer, and then approved it for treatment of endometriosis in 1990 and uterine fibroids in 1995. "There are thousands in the United States who say they have been victimized by this drug," Millican said, emphasizing that symptoms can be severe, such as tremors, seizures and memory loss. "Many women I know say their symptoms didn't stop when they stopped taking the drug." The FDA has received a wide range of reports of serious side-effects, including death, suspected to be associated with the use of Lupron, but the agency, which holds that the drug's benefits outweigh the risks, does not believe there is sufficient proof to blame Lupron. TAP Pharmaceuticals Inc., jointly owned by Abbott Laboratories and Takeda Chemical Industries of Japan, has steadfastly maintained that Lupron is safe. Millican, who feels that the FDA has been very slow on the draw with Lupron, is also frustrated by the lack of response from almost all of the many senators and representatives in Congress to whom she has written. She has even submitted written testimony to various committee hearings - but to no avail. "It seems that no one but the people who suffer from Lupron are interested in looking into this drug," she said. Millican cannot even recall anyone with an MD degree who has voiced strong concern about Lupron. At the very least, she feels Lupron's safety should be an issue because doctors use it for purposes that were never approved by the FDA. While legal under federal law - once approved for an indication, a drug can be used for other purposes - unapproved use often occurs without the benefit of appropriate safety and efficacy studies. One of Millican's main concerns is Lupron's unapproved use in fertility clinics. The drug is essentially used to suppress female hormones which produce a mature egg. This allows fertility doctors to then induce "controlled" stimulation of multiple eggs. "I am concerned that women who undergo these procedures are not being sufficiently informed about Lupron's side-effects," Millican said. There is even much more at stake, according to Millican. On September 5, she provided testimony to congressional committee hearings on stem cell research, pointing out that the use of Lupron in the process of creating embryos may cause "the very diseases that are being claimed as those diseases necessitating embryonic stem cell research for a cure." Millican finds it hard to swallow that the debate over stem cell research has totally ignored Lupron. Redflagsweekly January 25, 2002 Dr. Mercola's Comment: Folks, Lupron is a disaster drug that in no way shape or form treats the cause of the problem. I have seen it absolutely devastate many women's lives. It is one of the few drugs that I actually cringe when patients tell me that they have taken it. It is my experience and belief that this drug causes permanent neurological damage. This drug needs to be avoided at all costs. It is usually used for endometriosis, which is an estrogen dominance problem and is typically treated quite nicely with natural progesterone, a dietary program, and addressing the emotional stresses which cause the adrenal glands to become impaired Since the adrenals is the main biological of estrogen and progesterone, it is important to restore the proper functioning of this gland. One could take adrenal glandulars, or DHEA and pregnenolone, but those tend to be natural band-aids that don't address the reasons the adrenal became impaired. Answered by Larae Rolins 1 year ago.

I was one of the first guinea pigs to be prescribed Lupron for severe endometriosis in 1995. I had just undergone a laparoscopy and my ob-gyn insisted I try Lupron, especially, he said, because my husband and I had problems conceiving after one year of trying. The mood swings, migraines, dark, thick hair growth in weird places, hot flashes, and memory loss were only the beginning of the side effects I continue to have, 20 years later. I have not begun menopause, and the only baby that was conceived died in-utero at 16 weeks, and I never conceived again in my whole life. My endometriosis has gotten much worse, although I was diagnosed at stage 4 long ago, so I don t know what they would call the stage I have by now? 4+++? The pain has caused me to have to quit my dream job that I went to college for 7 years to work with children as a child psychologist, only to have my doctor reccomend I file for permanent disability because of the amount of pain medications I was taking to make it through the day, and the amount of memory loss I had incurred from Lupron. I have had hot flashes and mood swings for the past 20 years, so that now I need to take medication for PTSD for being attacked by a child at the school I worked with and my son I adopted when I was getting so sick and weak from the pain. I also have so many adhesions and scar tissue, it is really painful to eat a lot at once, because of the pain caused from intestinal blockages from the endometriosis. Please listen to those who have been on the medication and NOT your doctor!! YOu will also be at high risk for osteoporosis by the time you are 50, even if you are on Lupron for only 6 months. It is truly only a rotton bandaid that doctors get bonuses for and pharmaceutical companies get big bucks from the insurance at $2K per shot!! Don t do it! Answered by Billy Whistle 1 year ago.

I agree stop taking this drug. I have done two years of research because the dr. keeps pushing it on me. I have continued to tell him no. there was one dr. that said if I don't take it he wouldn't treat me. I didn't have him treat me. Dr.'s are trying to find a way out of solving problems, and this is NOT it. I am still struggling with endo and PCS, but I would rather struggle without the side effects. Best of luck to you. I hope you feel better REALLY soon. Answered by Marquerite Abeta 1 year ago.

I have met women who did Lupron and then when they went off of it had issues with extreme fatigue such as due to Chronic Fatigue Syndrome and even fibromyalgia. I haven't met any as of yet that had issues with insomnia or nausea when coming off the medication though. Answered by Cammie Laguerre 1 year ago.


Anyone else taken Lupron Depot?
I'm going to be going on this in a couple of weeks. I just wanted to know if anyone else has had experience with this. I've done the research, I know the side effects, but nothing else has worked for my endometriosis. I had surgery two months ago to have it removed and I'm going on Lupron so it... Asked by Heike Mobilio 1 year ago.

I'm going to be going on this in a couple of weeks. I just wanted to know if anyone else has had experience with this. I've done the research, I know the side effects, but nothing else has worked for my endometriosis. I had surgery two months ago to have it removed and I'm going on Lupron so it won't come back. Answered by Aleta Skewis 1 year ago.


Has anybody ever taken the lupron depot shot and what were the side effects?
would you recommend taking the injection to cure the endometriosis? Asked by Clyde Tenpas 1 year ago.

I had 3 lupron depot before I couldnt stand them anymore. My pain got worse with the shots not better. Then there was the hot flashes and mood swings. I wouldnt recommend the shots but that was just experience it might work for you. Answered by Jayna Cataline 1 year ago.

I tried it for two months and it did absolutely nothing except make me more miserable. A friend of mine had them for six months and she was worse off than me. I remember having hot flashes and night sweats that were far worse than actual menopause. The shot definitely did not cure my endometriosis. I ended up having a total hysterectomy which was far better than those awful shots. Maybe other people have had good results with Lupron but I did not. Good Luck!! Answered by Cletus Drehs 1 year ago.


While taking lupron and you become pregnant what will this do to the unborn baby?
my daughter in law has endormetriosis and was started on the lupron injections, she has since found out that she is pregnant and has been told this CAN cause damage to the fetus. She is 7 weeks so that would mean that she was about 1-2 weeks when she got the injection. Please help us find out about this Asked by Ray Lisowski 1 year ago.

Lupron is a category X drug and thereby contraindicated in pregnancy [use of Lupron during fertility workups are done in an off-label, alternate dose regimen, vs. the injection dosing schedule done for Endometriosis]. However, there is no immediate need for alarm. Here are some facts... *All* pregnancies are at a 3-5% risk of birth defects or mental retardation. In terms of Lupron exposure, there may be a *slight* increase in risks to the fetus when a woman is on Lupron at conception. However...this does *not* mean that the baby will be born with a problem, it simply means that Lupron research has revealed that a woman's pregnancy may be at an increased risk for miscarriage or possible defect. The concerns regarding this increased risk are based on the small number of studies of women who were exposed to Lupron during pregnancy, as well as the rat and rabbit models with the drug. The studies showed that of the 125 women studied [who were exposed to Lupron at the time of pregnancy], 35 miscarried (28%), 1 terminated for Trisomy 18, 3 were ectopic pregnancies (2.4%), and 2 of the 125 total infants had congenital anomalies which included bilateral inguinal hernia and atretic kidney. In studies of the children born, 1 had a cleft palate, 1 had a seizure disorder, and 3 had ADHD. Again, however, this is a very small study group and is not enough to confirm any forgone conclusions about in utero exposure to any GnRHs. It is recommend in the clinical research data that Level II ultrasound is performed at 18-20 weeks to confirm the healthy progress of the developing fetus. Maternal Serum Marker Screening may also be considered. It is imperative that your DIL does not feel any guilt or anxiety over this and that she is afforded a strong support system. Chances are in her favor that everything will be fine. Good luck to you all. Answered by Chang Alberta 1 year ago.

This Site Might Help You. RE: while taking lupron and you become pregnant what will this do to the unborn baby? my daughter in law has endormetriosis and was started on the lupron injections, she has since found out that she is pregnant and has been told this CAN cause damage to the fetus. She is 7 weeks so that would mean that she was about 1-2 weeks when she got the injection. Please help us find out... Answered by Daphine Ayersman 1 year ago.

Lupron And Pregnancy Answered by Sonia Dellasanta 1 year ago.

It is important to remember that Lupron is not a contraceptive and it is possible for pregnancy to occur during therapy. Even if you are not having periods, ovulation could occur. so use extra protection!!!! (unless you want to get pregnant then don't) Answered by Cassi Mania 1 year ago.

I was taking Lupron injections during my fertility treatments when trying to get pregnant. Assuming that she's stopped taking it, she should be fine, but I suggest that she ask her doctor to make sure. Good luck and congrats! Answered by Kristina Cancel 1 year ago.

usually nothing...most of the vital organs dont even start to develop yet at one to two weeks... Answered by Hershel Chaney 1 year ago.


Dows anyone know how long someone can be on Depo Lupron before any long term effects begin showing up?
I have been on the drug for 6 months at a time off and on for the past 5 years and I am curious about the length of time one can be on this treatment. Asked by Felice Kirksey 1 year ago.

Lupron is only FDA approved and manufacturer recommended for one use followed by one retreatment in a lifetime. That means, if you take the 3.75 dosage for 6 months, you can take another 3.75 injections x 6 more months - but ONLY with the mandatory Aygestin addback. Beyond that, use is not recommended or clinically supported. The potential long-term effects of the off label usage you are undergoing may be drastic; unfortunately, no one knows for sure because the drug has never been studied nor was it intended for long term use. At the very outset, your bone mass density is of concern - your prescribing physician should be sending you for a DEXA annually. Bone loss with long-term Lupron usage is signficant and irreversible. As for other effects, metabolic and endocrine impact may also be significant and you should have your thyroid and cholesterol levels checked as well. Lupron has a list of potential side effects in all users, not just long-termers, that is as long as the package insert itself and it's really unfortunate that your doctor hasn't provided you with all the information needed to make an educated decision about your treatment options. Lupron is not and was never intended to be used for the long-term and there is a reason it is only approved for 1 use and 1 retreatment. If I were you I would find a new doc who can offer other options for my treatment. Good luck and hope it all turns out ok. Answered by Sherill Weatherill 1 year ago.

We had a foster dog who had parvo. He needed to keep on the vet's workplace for per week. After that he got here residence and used to be exceptional, at the day we introduced him residence he used to be somewhat pig all he desired to do used to be devour. Try boiling a few bird to look if he's going to devour that. Whatever you do do not deliver him salt, a good way to motive dehydration quicker and an excessive amount of salt isn't well for puppies. You too can combine white rice in with the bird. Try to preserve him on a bland nutrition. Nothing with an excessive amount of taste that would dissatisfied his digestive procedure given that he hasn't eaten in a even as. Continue with the pedialyte specifically if he isn't consuming adequate water. Our dog, so far as I recognize, has now not had any long run results. He has been followed and we have not heard something unhealthy from the foster loved ones so I'm guessing that the whole lot has been exceptional. Good Luck, I wish he will get larger! Answered by Myra Camm 1 year ago.

Why so long ? Normally it shouldn't be longer than several weeks. Answered by Kerri Gandarilla 1 year ago.


My daughters doctor is recommending lupron. Can anyone tell me about the side effects. She is 8?
She has been diagnosed with early puberrty. Asked by Celestina Peller 1 year ago.

Lupron Depot belongs to a class of drugs called gonadotropin-releasing hormone (GnRH) agonists. It is used to decrease the body’s production of specific hormones, natural chemicals that influence the behavior of certain cells. Because Lupron Depot can reduce the production of both male and female hormones, it is used to treat specific conditions in men, women, and children. Side effects of Lupron can include pain, burning, itching, and redness or swelling at the site of injection. In girls, some rare cases may experience vaginal bleeding or a white vaginal discharge. After several weeks of treatment, girls may experience side effects similar to those associated with menopause, including: * hot flashes * vaginal dryness * insomnia Long-term use of Lupron also can cause a decrease in bone density, so girls who take Lupron are encouraged to take calcium supplements daily. Sometimes, small amounts of the female hormone estrogen can also help alleviate side effects. Answered by Malka Panchana 1 year ago.

Lupron is typically used in infertility medication. I took it when they were trying to regulate my menstrual cycle to start infertility treatments. I personally did not experience any side effects but I would suggest contacting a pharmacist for more information. Good luck to you and your daughter. Answered by Noma Maccarthy 1 year ago.


Anyone taking Lupron medication?
On Lupron injections to help shrink fibroids & control bleeding during future myomectomy to remove them - how soon after the last shot did your menstruation return? What was your first post-surgery menstruation like? Asked by Samual Gudis 1 year ago.

Leuprolide (generic name) Lupron (brand name) is used to treat: * symptoms of advanced prostate cancer in men * endometriosis (condition in which cells normally found in the uterus become implanted in other areas of the body) in women * uterine fibroids (noncancerous growths in the uterus) in women * central precocious puberty (a condition causing children to enter puberty too soon, resulting in accelerated bone growth and the development of sexual characteristics) in girls usually younger than 8 years of age and in boys usually younger than 9 years of age Leuprolide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: * weakness * headache * dizziness * hot flashes (a sudden wave of mild or intense body heat) * sweating or night sweats * tiredness * nausea * vomiting * diarrhea * constipation * loss of appetite * change in weight * increased need to urinate, especially at night * breast tenderness or change in breast size in both men and women * decrease in sexual desire in men and women or ability to perform in men * decrease in size of testicles * vaginal discharge, dryness, or itching in women * absence of menstrual periods in women * spotting (light vaginal bleeding) * swelling of the hands, feet, ankles, or lower legs * depression * difficulty concentrating * anxiety or nervousness * difficulty with memory * difficulty falling asleep or staying asleep * flu-like symptoms * muscle aches * itching, swelling, burning, stinging, pain, bruising, redness, or development of a sore at injection spot * firmness or hardness at subcutaneous injection spot * bleeding, bruising, burning, pain, pressure, itching, swelling, or redness at the place where the implant was inserted * hair loss * acne Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately: * hives * rash * itching * difficulty breathing or swallowing * numbness, tingling, weakness, or pain in the feet or lower legs * painful or difficult urination * blood in urine * bone pain * testicular or prostate pain * inability to move arms or legs There is an increased risk of osteoporosis (condition in which the bones become weak and fragile and can break easily) while using leuprolide. Talk with your doctor about the risks of using leuprolide. In children receiving leuprolide for early puberty, signs of sexual development may not decrease or may increase during the first few weeks of treatment. In girls receiving leuprolide for early puberty, the onset of menstruation or spotting (light vaginal bleeding) may occur during the first two months of treatment. If bleeding continues beyond the second month, call your doctor. Myomectomy: This surgery removes the fibroids. It is frequently the chosen treatment for women who want to have children, because it usually can preserve fertility. Another advantage of a myomectomy is that it controls pain or excessive bleeding that some women with uterine fibroids have. More fibroids can develop after myomectomy. Answered by Jacalyn Deanhardt 1 year ago.

Well, I took 4 doses of lupron for 4 months ( 1 dose once a month)when doctors found that i had multiple fibroids inside my uterus. In the mid of 4 months I got married and had unprotected sex but i didn't get pregnant. Lupron stops ovulation and period so there in no chance to get pregnant when are taking lupron. By the way i was 25 then. But Its not good to take more then 4 doses of lupron in a year. Answered by Daina Mchorse 1 year ago.


Lupron depot?
complcations with long use?i haveon this for almost 9 years Asked by Jadwiga Beiser 1 year ago.

I was on it about 13 years ago. I didn't have any problems with it other than it shut down my cycles for those 6 months. You'll be fine. After those, you should consider Seasonale birth control. I've been on that for the last 2 years for my endometriosis. Before that I was on the depo provera shots for 9 years Answered by Alice Rihner 1 year ago.


Has anyone with endometriosis had a good experience with Lupron?
I have had two laparoscopies in the past three years and I'm having pain again. The doctor suggested this instead since I don't want to get pregnant right now. Any input would be great! Thanks. Asked by Ronnie Barbin 1 year ago.

Worst drug I have ever taken. I would never recommend it for anyone. I had such horrible side effects and I only took it for 3 months. Look at Endo's post above for the side effects. That's a pretty good list of what I went through for 3 months. I lost 16 pounds over that time and had one headache that never went away. If possible find another way. This isn't good. There are also other GnRH agonists out there - Synarel (nasal spray) and Zolodex (subcutaneous implant). The implant is supposed to be painful. If you have to go this route maybe Synarel is better because it is a daily nasal spray and you can stop it if you have problems. Lupron is a depot injection. Once in it can't be taken out. If you have problems you are screwed for about a month! Answered by Jesus Augello 1 year ago.

I had a terrible experience with Lupron. It gave me considerable pain in my hip and other problems. At one point, I could barely walk! Another friend of mine had similar problems. I would avoid it. Answered by Josefa Kane 1 year ago.


What are your experiences with depot lupron?
I have had horrible side effects from the Depot Lupron shot (3-months doasage), now I am not talking about depot provera, this is a stronger shot to treat endometriosis. It has helped with the pain and lessened the growths, but I have bad hot flashes, weight gain, dryness, the list goes on. Anyone have better... Asked by Latosha Hattier 1 year ago.

I have had horrible side effects from the Depot Lupron shot (3-months doasage), now I am not talking about depot provera, this is a stronger shot to treat endometriosis. It has helped with the pain and lessened the growths, but I have bad hot flashes, weight gain, dryness, the list goes on. Anyone have better experience with it? Can anyone suggest an alternative treatment?? BCPs don't work, i tried them already. Answered by Garland Beauchesne 1 year ago.

Stay FAR away from Lupron!!!!! Endo is an estrogen dominance disease. You need to replace the progesterone that your body is missing with a NATURAL PROGESTERONE CREAM! Email me and I can tell you more. This is some very nasty stuff. :( Here is an article I found.... Be Careful of Lupron for Endometriosis, It Could Be the Kiss of Death By Nicholas Regush This particular saga began a decade ago with an injection of a powerful prescription drug called Lupron. Lynne Millican took the shot for endometriosis, a condition in which pieces of the lining of the uterus are found in other parts of the body, especially in the pelvic cavity. Ten years later, Millican believes she is still suffering from the effects of that injection. Her many symptoms have included the development of a noncancerous tumor, breast cysts, cardiac arrythmias, dizziness, swelling and fatigue. Millican is a registered nurse (and paralegal) living in the Boston area who has become deeply involved in a grass-roots movement to force the U.S. Food and Drug Administration (FDA), and Members of Congress to take a close look at Lupron. The FDA first approved Lupron in 1985 for treatment of men with advanced prostate cancer, and then approved it for treatment of endometriosis in 1990 and uterine fibroids in 1995. "There are thousands in the United States who say they have been victimized by this drug," Millican said, emphasizing that symptoms can be severe, such as tremors, seizures and memory loss. "Many women I know say their symptoms didn't stop when they stopped taking the drug." The FDA has received a wide range of reports of serious side-effects, including death, suspected to be associated with the use of Lupron, but the agency, which holds that the drug's benefits outweigh the risks, does not believe there is sufficient proof to blame Lupron. TAP Pharmaceuticals Inc., jointly owned by Abbott Laboratories and Takeda Chemical Industries of Japan, has steadfastly maintained that Lupron is safe. Millican, who feels that the FDA has been very slow on the draw with Lupron, is also frustrated by the lack of response from almost all of the many senators and representatives in Congress to whom she has written. She has even submitted written testimony to various committee hearings - but to no avail. "It seems that no one but the people who suffer from Lupron are interested in looking into this drug," she said. Millican cannot even recall anyone with an MD degree who has voiced strong concern about Lupron. At the very least, she feels Lupron's safety should be an issue because doctors use it for purposes that were never approved by the FDA. While legal under federal law - once approved for an indication, a drug can be used for other purposes - unapproved use often occurs without the benefit of appropriate safety and efficacy studies. One of Millican's main concerns is Lupron's unapproved use in fertility clinics. The drug is essentially used to suppress female hormones which produce a mature egg. This allows fertility doctors to then induce "controlled" stimulation of multiple eggs. "I am concerned that women who undergo these procedures are not being sufficiently informed about Lupron's side-effects," Millican said. There is even much more at stake, according to Millican. On September 5, she provided testimony to congressional committee hearings on stem cell research, pointing out that the use of Lupron in the process of creating embryos may cause "the very diseases that are being claimed as those diseases necessitating embryonic stem cell research for a cure." Millican finds it hard to swallow that the debate over stem cell research has totally ignored Lupron. Redflagsweekly January 25, 2002 Dr. Mercola's Comment: Folks, Lupron is a disaster drug that in no way shape or form treats the cause of the problem. I have seen it absolutely devastate many women's lives. It is one of the few drugs that I actually cringe when patients tell me that they have taken it. It is my experience and belief that this drug causes permanent neurological damage. This drug needs to be avoided at all costs. It is usually used for endometriosis, which is an estrogen dominance problem and is typically treated quite nicely with natural progesterone, a dietary program, and addressing the emotional stresses which cause the adrenal glands to become impaired Since the adrenals is the main biological of estrogen and progesterone, it is important to restore the proper functioning of this gland. One could take adrenal glandulars, or DHEA and pregnenolone, but those tend to be natural band-aids that don't address the reasons the adrenal became impaired. Answered by Lieselotte Ranum 1 year ago.

I was one of the first guinea pigs to be prescribed Lupron for severe endometriosis in 1995. I had just undergone a laparoscopy and my ob-gyn insisted I try Lupron, especially, he said, because my husband and I had problems conceiving after one year of trying. The mood swings, migraines, dark, thick hair growth in weird places, hot flashes, and memory loss were only the beginning of the side effects I continue to have, 20 years later. I have not begun menopause, and the only baby that was conceived died in-utero at 16 weeks, and I never conceived again in my whole life. My endometriosis has gotten much worse, although I was diagnosed at stage 4 long ago, so I don t know what they would call the stage I have by now? 4+++? The pain has caused me to have to quit my dream job that I went to college for 7 years to work with children as a child psychologist, only to have my doctor reccomend I file for permanent disability because of the amount of pain medications I was taking to make it through the day, and the amount of memory loss I had incurred from Lupron. I have had hot flashes and mood swings for the past 20 years, so that now I need to take medication for PTSD for being attacked by a child at the school I worked with and my son I adopted when I was getting so sick and weak from the pain. I also have so many adhesions and scar tissue, it is really painful to eat a lot at once, because of the pain caused from intestinal blockages from the endometriosis. Please listen to those who have been on the medication and NOT your doctor!! YOu will also be at high risk for osteoporosis by the time you are 50, even if you are on Lupron for only 6 months. It is truly only a rotton bandaid that doctors get bonuses for and pharmaceutical companies get big bucks from the insurance at $2K per shot!! Don t do it! Answered by Milagros Milosevich 1 year ago.

I agree stop taking this drug. I have done two years of research because the dr. keeps pushing it on me. I have continued to tell him no. there was one dr. that said if I don't take it he wouldn't treat me. I didn't have him treat me. Dr.'s are trying to find a way out of solving problems, and this is NOT it. I am still struggling with endo and PCS, but I would rather struggle without the side effects. Best of luck to you. I hope you feel better REALLY soon. Answered by Fawn Rebeck 1 year ago.

I have met women who did Lupron and then when they went off of it had issues with extreme fatigue such as due to Chronic Fatigue Syndrome and even fibromyalgia. I haven't met any as of yet that had issues with insomnia or nausea when coming off the medication though. Answered by Aida Guadeloupe 1 year ago.


Anyone else taken Lupron Depot?
I'm going to be going on this in a couple of weeks. I just wanted to know if anyone else has had experience with this. I've done the research, I know the side effects, but nothing else has worked for my endometriosis. I had surgery two months ago to have it removed and I'm going on Lupron so it... Asked by Jude Smittle 1 year ago.

I'm going to be going on this in a couple of weeks. I just wanted to know if anyone else has had experience with this. I've done the research, I know the side effects, but nothing else has worked for my endometriosis. I had surgery two months ago to have it removed and I'm going on Lupron so it won't come back. Answered by Shin Lancia 1 year ago.


Has anybody ever taken the lupron depot shot and what were the side effects?
would you recommend taking the injection to cure the endometriosis? Asked by Erlinda Honie 1 year ago.

I had 3 lupron depot before I couldnt stand them anymore. My pain got worse with the shots not better. Then there was the hot flashes and mood swings. I wouldnt recommend the shots but that was just experience it might work for you. Answered by Aleen Hoops 1 year ago.

I tried it for two months and it did absolutely nothing except make me more miserable. A friend of mine had them for six months and she was worse off than me. I remember having hot flashes and night sweats that were far worse than actual menopause. The shot definitely did not cure my endometriosis. I ended up having a total hysterectomy which was far better than those awful shots. Maybe other people have had good results with Lupron but I did not. Good Luck!! Answered by Katherina Bonfiglio 1 year ago.


While taking lupron and you become pregnant what will this do to the unborn baby?
my daughter in law has endormetriosis and was started on the lupron injections, she has since found out that she is pregnant and has been told this CAN cause damage to the fetus. She is 7 weeks so that would mean that she was about 1-2 weeks when she got the injection. Please help us find out about this Asked by Freddie Getsinger 1 year ago.

Lupron is a category X drug and thereby contraindicated in pregnancy [use of Lupron during fertility workups are done in an off-label, alternate dose regimen, vs. the injection dosing schedule done for Endometriosis]. However, there is no immediate need for alarm. Here are some facts... *All* pregnancies are at a 3-5% risk of birth defects or mental retardation. In terms of Lupron exposure, there may be a *slight* increase in risks to the fetus when a woman is on Lupron at conception. However...this does *not* mean that the baby will be born with a problem, it simply means that Lupron research has revealed that a woman's pregnancy may be at an increased risk for miscarriage or possible defect. The concerns regarding this increased risk are based on the small number of studies of women who were exposed to Lupron during pregnancy, as well as the rat and rabbit models with the drug. The studies showed that of the 125 women studied [who were exposed to Lupron at the time of pregnancy], 35 miscarried (28%), 1 terminated for Trisomy 18, 3 were ectopic pregnancies (2.4%), and 2 of the 125 total infants had congenital anomalies which included bilateral inguinal hernia and atretic kidney. In studies of the children born, 1 had a cleft palate, 1 had a seizure disorder, and 3 had ADHD. Again, however, this is a very small study group and is not enough to confirm any forgone conclusions about in utero exposure to any GnRHs. It is recommend in the clinical research data that Level II ultrasound is performed at 18-20 weeks to confirm the healthy progress of the developing fetus. Maternal Serum Marker Screening may also be considered. It is imperative that your DIL does not feel any guilt or anxiety over this and that she is afforded a strong support system. Chances are in her favor that everything will be fine. Good luck to you all. Answered by Tom Huntington 1 year ago.

This Site Might Help You. RE: while taking lupron and you become pregnant what will this do to the unborn baby? my daughter in law has endormetriosis and was started on the lupron injections, she has since found out that she is pregnant and has been told this CAN cause damage to the fetus. She is 7 weeks so that would mean that she was about 1-2 weeks when she got the injection. Please help us find out... Answered by Matthew Welter 1 year ago.

Lupron And Pregnancy Answered by Casandra Stevens 1 year ago.

It is important to remember that Lupron is not a contraceptive and it is possible for pregnancy to occur during therapy. Even if you are not having periods, ovulation could occur. so use extra protection!!!! (unless you want to get pregnant then don't) Answered by Mi Echavez 1 year ago.

I was taking Lupron injections during my fertility treatments when trying to get pregnant. Assuming that she's stopped taking it, she should be fine, but I suggest that she ask her doctor to make sure. Good luck and congrats! Answered by Donnette Zerbel 1 year ago.

usually nothing...most of the vital organs dont even start to develop yet at one to two weeks... Answered by Edra Stempien 1 year ago.


Dows anyone know how long someone can be on Depo Lupron before any long term effects begin showing up?
I have been on the drug for 6 months at a time off and on for the past 5 years and I am curious about the length of time one can be on this treatment. Asked by Vanda Beddo 1 year ago.

Lupron is only FDA approved and manufacturer recommended for one use followed by one retreatment in a lifetime. That means, if you take the 3.75 dosage for 6 months, you can take another 3.75 injections x 6 more months - but ONLY with the mandatory Aygestin addback. Beyond that, use is not recommended or clinically supported. The potential long-term effects of the off label usage you are undergoing may be drastic; unfortunately, no one knows for sure because the drug has never been studied nor was it intended for long term use. At the very outset, your bone mass density is of concern - your prescribing physician should be sending you for a DEXA annually. Bone loss with long-term Lupron usage is signficant and irreversible. As for other effects, metabolic and endocrine impact may also be significant and you should have your thyroid and cholesterol levels checked as well. Lupron has a list of potential side effects in all users, not just long-termers, that is as long as the package insert itself and it's really unfortunate that your doctor hasn't provided you with all the information needed to make an educated decision about your treatment options. Lupron is not and was never intended to be used for the long-term and there is a reason it is only approved for 1 use and 1 retreatment. If I were you I would find a new doc who can offer other options for my treatment. Good luck and hope it all turns out ok. Answered by Joeann Gormally 1 year ago.

We had a foster dog who had parvo. He needed to keep on the vet's workplace for per week. After that he got here residence and used to be exceptional, at the day we introduced him residence he used to be somewhat pig all he desired to do used to be devour. Try boiling a few bird to look if he's going to devour that. Whatever you do do not deliver him salt, a good way to motive dehydration quicker and an excessive amount of salt isn't well for puppies. You too can combine white rice in with the bird. Try to preserve him on a bland nutrition. Nothing with an excessive amount of taste that would dissatisfied his digestive procedure given that he hasn't eaten in a even as. Continue with the pedialyte specifically if he isn't consuming adequate water. Our dog, so far as I recognize, has now not had any long run results. He has been followed and we have not heard something unhealthy from the foster loved ones so I'm guessing that the whole lot has been exceptional. Good Luck, I wish he will get larger! Answered by Ethan Sluter 1 year ago.

Why so long ? Normally it shouldn't be longer than several weeks. Answered by Portia Calicut 1 year ago.


My daughters doctor is recommending lupron. Can anyone tell me about the side effects. She is 8?
She has been diagnosed with early puberrty. Asked by Carolyn Lizana 1 year ago.

Lupron Depot belongs to a class of drugs called gonadotropin-releasing hormone (GnRH) agonists. It is used to decrease the body’s production of specific hormones, natural chemicals that influence the behavior of certain cells. Because Lupron Depot can reduce the production of both male and female hormones, it is used to treat specific conditions in men, women, and children. Side effects of Lupron can include pain, burning, itching, and redness or swelling at the site of injection. In girls, some rare cases may experience vaginal bleeding or a white vaginal discharge. After several weeks of treatment, girls may experience side effects similar to those associated with menopause, including: * hot flashes * vaginal dryness * insomnia Long-term use of Lupron also can cause a decrease in bone density, so girls who take Lupron are encouraged to take calcium supplements daily. Sometimes, small amounts of the female hormone estrogen can also help alleviate side effects. Answered by Kattie Pruss 1 year ago.

Lupron is typically used in infertility medication. I took it when they were trying to regulate my menstrual cycle to start infertility treatments. I personally did not experience any side effects but I would suggest contacting a pharmacist for more information. Good luck to you and your daughter. Answered by Janene Starrick 1 year ago.


Anyone taking Lupron medication?
On Lupron injections to help shrink fibroids & control bleeding during future myomectomy to remove them - how soon after the last shot did your menstruation return? What was your first post-surgery menstruation like? Asked by Sonny Hashimoto 1 year ago.

Leuprolide (generic name) Lupron (brand name) is used to treat: * symptoms of advanced prostate cancer in men * endometriosis (condition in which cells normally found in the uterus become implanted in other areas of the body) in women * uterine fibroids (noncancerous growths in the uterus) in women * central precocious puberty (a condition causing children to enter puberty too soon, resulting in accelerated bone growth and the development of sexual characteristics) in girls usually younger than 8 years of age and in boys usually younger than 9 years of age Leuprolide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: * weakness * headache * dizziness * hot flashes (a sudden wave of mild or intense body heat) * sweating or night sweats * tiredness * nausea * vomiting * diarrhea * constipation * loss of appetite * change in weight * increased need to urinate, especially at night * breast tenderness or change in breast size in both men and women * decrease in sexual desire in men and women or ability to perform in men * decrease in size of testicles * vaginal discharge, dryness, or itching in women * absence of menstrual periods in women * spotting (light vaginal bleeding) * swelling of the hands, feet, ankles, or lower legs * depression * difficulty concentrating * anxiety or nervousness * difficulty with memory * difficulty falling asleep or staying asleep * flu-like symptoms * muscle aches * itching, swelling, burning, stinging, pain, bruising, redness, or development of a sore at injection spot * firmness or hardness at subcutaneous injection spot * bleeding, bruising, burning, pain, pressure, itching, swelling, or redness at the place where the implant was inserted * hair loss * acne Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately: * hives * rash * itching * difficulty breathing or swallowing * numbness, tingling, weakness, or pain in the feet or lower legs * painful or difficult urination * blood in urine * bone pain * testicular or prostate pain * inability to move arms or legs There is an increased risk of osteoporosis (condition in which the bones become weak and fragile and can break easily) while using leuprolide. Talk with your doctor about the risks of using leuprolide. In children receiving leuprolide for early puberty, signs of sexual development may not decrease or may increase during the first few weeks of treatment. In girls receiving leuprolide for early puberty, the onset of menstruation or spotting (light vaginal bleeding) may occur during the first two months of treatment. If bleeding continues beyond the second month, call your doctor. Myomectomy: This surgery removes the fibroids. It is frequently the chosen treatment for women who want to have children, because it usually can preserve fertility. Another advantage of a myomectomy is that it controls pain or excessive bleeding that some women with uterine fibroids have. More fibroids can develop after myomectomy. Answered by Bebe Sandstrom 1 year ago.

Well, I took 4 doses of lupron for 4 months ( 1 dose once a month)when doctors found that i had multiple fibroids inside my uterus. In the mid of 4 months I got married and had unprotected sex but i didn't get pregnant. Lupron stops ovulation and period so there in no chance to get pregnant when are taking lupron. By the way i was 25 then. But Its not good to take more then 4 doses of lupron in a year. Answered by Nu Banta 1 year ago.


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