Application Information

This drug has been submitted to the FDA under the reference 016949/001.

Names and composition

"LIMBITROL" is the commercial name of a drug composed of AMITRIPTYLINE HYDROCHLORIDE and CHLORDIAZEPOXIDE.

Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
016949/001 LIMBITROL AMITRIPTYLINE HYDROCHLORIDE; CHLORDIAZEPOXIDE TABLET/ORAL EQ 12.5MG BASE and 5MG

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
016949/001 LIMBITROL AMITRIPTYLINE HYDROCHLORIDE; CHLORDIAZEPOXIDE TABLET/ORAL EQ 12.5MG BASE and 5MG
016949/002 LIMBITROL DS AMITRIPTYLINE HYDROCHLORIDE; CHLORDIAZEPOXIDE TABLET/ORAL EQ 25MG BASE and 10MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
070477/001 CHLORDIAZEPOXIDE AND AMITRIPTYLINE HYDROCHLORIDE AMITRIPTYLINE HYDROCHLORIDE; CHLORDIAZEPOXIDE TABLET/ORAL EQ 12.5MG BASE and 5MG
070478/001 CHLORDIAZEPOXIDE AND AMITRIPTYLINE HYDROCHLORIDE AMITRIPTYLINE HYDROCHLORIDE; CHLORDIAZEPOXIDE TABLET/ORAL EQ 25MG BASE and 10MG
070765/001 CHLORDIAZEPOXIDE AND AMITRIPTYLINE HYDROCHLORIDE AMITRIPTYLINE HYDROCHLORIDE; CHLORDIAZEPOXIDE TABLET/ORAL EQ 12.5MG BASE and 5MG
070766/001 CHLORDIAZEPOXIDE AND AMITRIPTYLINE HYDROCHLORIDE AMITRIPTYLINE HYDROCHLORIDE; CHLORDIAZEPOXIDE TABLET/ORAL EQ 25MG BASE and 10MG
071296/001 CHLORDIAZEPOXIDE AND AMITRIPTYLINE HYDROCHLORIDE AMITRIPTYLINE HYDROCHLORIDE; CHLORDIAZEPOXIDE TABLET/ ORAL EQ 12.5MG BASE and 5MG
071297/001 CHLORDIAZEPOXIDE AND AMITRIPTYLINE HYDROCHLORIDE AMITRIPTYLINE HYDROCHLORIDE; CHLORDIAZEPOXIDE TABLET/ORAL EQ 25MG BASE and 10MG
071297/002 CHLORDIAZEPOXIDE AND AMITRIPTYLINE HYDROCHLORIDE AMITRIPTYLINE HYDROCHLORIDE; CHLORDIAZEPOXIDE TABLET/ORAL EQ 12.5MG BASE and 5MG
072052/001 CHLORDIAZEPOXIDE AND AMITRIPTYLINE HYDROCHLORIDE AMITRIPTYLINE HYDROCHLORIDE; CHLORDIAZEPOXIDE TABLET/ORAL EQ 12.5MG BASE and 5MG
072053/001 CHLORDIAZEPOXIDE AND AMITRIPTYLINE HYDROCHLORIDE AMITRIPTYLINE HYDROCHLORIDE; CHLORDIAZEPOXIDE TABLET/ORAL EQ 25MG BASE and 10MG
072277/001 CHLORDIAZEPOXIDE AND AMITRIPTYLINE HYDROCHLORIDE AMITRIPTYLINE HYDROCHLORIDE; CHLORDIAZEPOXIDE TABLET/ORAL EQ 12.5MG BASE and 5MG
072278/001 CHLORDIAZEPOXIDE AND AMITRIPTYLINE HYDROCHLORIDE AMITRIPTYLINE HYDROCHLORIDE; CHLORDIAZEPOXIDE TABLET/ORAL EQ 25MG BASE and 10MG

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Answered questions

What makes Methadone levels rise in your system?
I took my monthly UA and for some reason this month the levels are extremely high for my methadone. I haven't really changed anything in the last couple of months so I don't understand why the levels are raised.. Can anyone help? Asked by Bree Desaulniers 1 year ago.

There are many things that can cause this. Other medications can do it as well as foods and certain beverages can increase the level of methadone in your system. Drugs used in the treatment of depression and anxiety, such as Elavil®, Triavil®, Endep®, and Limbitrol® (generic name - amitriptyline) may increase plasma levels of methadone, along with Tagamet® (cimetidine), which is used in the treatment of gastric and duodenal ulcers. Drugs used in the treatment of anxiety, such as Valium® may also have this affect. Fluconazole (Diflucan, a drug used to treat fungal infections) can raise methadone levels by 30% . In one study of this effect, no overdoses were reported. Ketaconazole (Nizoral) can have a similar effect. Also urinary alkalinizers (Bicitra, Polycitra) used to treat gout and kidney stones can also increase the levels of methadone. Grape fruit and grape fruit juice may cause an increase in methadone levels as well. There are so many things out there that can do it. ALSO, depending on how long you have been taking methadone and because methadone is metabolized much slower, it is possible that over time you have built up a large amount of methadone in your system. For example, when you take a dose of methadone, it is metabolized much slower than other opiate medications. It has a "half life" which means that it takes it twice as long to metabolize in your body. So if you take your dose on Monday, by the time it is time for your dose again on Tues, you still will have half of the methadone still trying to be metabolized by your body. So in fact, each day you are adding a bit more each time and it is possible to have higher levels than when you originally started the medication. This is especially true if you take a "split dose" or take more than one dose in a day. Answered by Mayola Ewin 1 year ago.

As consistent with the large blunders of judgement made by means of Mars (final yr I suppose), the whey used may also be vegetarian or non-vegetarian. Whilst I suppose that Mars have now reverted to utilizing vegetarian whey in all in their chocolate bars, as a vegetarian out of foremost I is not going to consume any of them. If Mars inspiration so little in their vegetarian consumers that they made that determination, then I haven't any want to be a purchaser of theirs. Nestle honestly have a record on their internet site of vegetarian merchandise - entails Aero, a few After Eight, Some Black Magic, Drifter, Heaven, a few Kit Kat and Matchmakers among others - fine to have a appear your self for a whole record. I'm no longer certain why Nestle do not placed 'suitable for vegetarians' on plenty in their packets. The majority of Cadbury's chocolate bars are vegetarian. Green and Blacks are vegetarian, and a few are vegan. A lot of Thorntons are vegetarian. Ferro Rocher are NOT vegetarian. A lot of Marks & Spencers chocolate does not state vegetarian - no longer certain why. Answered by Xiomara Byod 1 year ago.


What to do when SSRIs aren't working for SEVERE anxiety?
I have been suffering from severe anxiety, and I have taken several types of anxiety medications, and almost none of them have worked. In the past, I have taken Zoloft, Abilify, BuSpar, Lamictal, Neurontin, Paxil, Seroquel, Lexapro, and several benzodiazepines for panic attacks such as Valium, Ativan, Xanax, and... Asked by Karl Olexy 1 year ago.

I have been suffering from severe anxiety, and I have taken several types of anxiety medications, and almost none of them have worked. In the past, I have taken Zoloft, Abilify, BuSpar, Lamictal, Neurontin, Paxil, Seroquel, Lexapro, and several benzodiazepines for panic attacks such as Valium, Ativan, Xanax, and Librium. Out of the benzos, the only one that has really worked was the Valium. And as for the other long-term medications I mentioned, none of them worked at all. I currently take Limbitrol, and it has not helped my anxiety at all, and has made complex thinking very difficult. Anyway, as you can see, over the past few years I have taken many different types of medications, and only Valium has helped, and my psychiatrist is afraid that I'm becoming codependent on it, which he may be right about. I'd like for someone who's been in a similar situation, or has a great knowledge of psycho pharmacology to perhaps suggest what to do. My psychiatrist is nothing short of stumped, and I'm slowly losing my ability to function due to the crippling anxiety, and to top it all off I'm only 14 years old! I've been in intensive therapy for years and it's accomplished nothing, and I'm starting to rely on medications more and more. And they're not working either! I am at my wits' end, and I'm losing sleep from anxiety. I'd just like someone to perhaps suggest a drug, or class of drugs to try, because nothing I've tried have worked. SSRIs simply do not work for me. I would greatly appreciate any suggestions at all. Answered by Raguel Larke 1 year ago.

you're 14? your psychiatrist is not stumped. he just doesn't want to give you valium. you are much too young to be taking most of those medications. why not switch doctors? and discuss it with your therapist Answered by Nancey Ferniza 1 year ago.


IBS.........this really sucks!!?
I have had every test imaginable in the past 6 years and I still have chronic diaherra, anal fissure, bloating, gas, stomach and abdominal cramps, left side pain, back pain, tiredness, farts that lead to shitting my pants! Its right down disgusting! I am currently not taking any medications as my symptoms went away... Asked by Diedre Klunk 1 year ago.

I have had every test imaginable in the past 6 years and I still have chronic diaherra, anal fissure, bloating, gas, stomach and abdominal cramps, left side pain, back pain, tiredness, farts that lead to shitting my pants! Its right down disgusting! I am currently not taking any medications as my symptoms went away completely for over 6 months I hate how they come n go or show up without warning what kind of natural things can I do as I have no health ins right now to get any meds Answered by Kurt Ehleiter 1 year ago.

IBS does NOT typically some of the symptoms you describe so you either have a different problem than IBS or you have multiple problems. Just because you don't have health insurance does not mean you can't get some effective medication. Most medications that help IBS are old and cheap. Here are a number of medications that are used for IBS- some are better known for IBS use, some are not. Antispasmodic/anxiolytic should help with abdominal cramps and may have an effect on all other symptoms. HIGHLY RECOMMEND Donnatal (belladonna alkaloids/phenobarbital) ($ 4-6 USD) Librax (chlordiazepoxide/clidinium) ($ 20-30 USD) Antispasmodic- unlike Donnatal or Librax these medications don't contain an anxiolytic. Bentyl (dicyclomine) ($ 12-15 USD) NuLev (hyoscyamine ODT) ($ 20 USD) Antidepressants- shown to help with nearly all aspects of IBS Elavil (amitriptyline) ($ 10-15 USD) Tofranil (imipramine) ($ 15-18 USD) Prozac (fluoxetine) ($ 12-25 USD) Antidepressant/anxiolytic- combination of two drugs both of which can help with IBS symptoms. Limbitrol (chlordiazepoxide/amitriptyline) ($ 30-40 USD) Anti-diarrhoeal Imodium (loperamide) ($ 7-12 USD)- this may be more beneficial for other symptoms in addition to diarrhoea Lomotil (diphenoxylate/atropine) ($13-25 USD)- this may also help with abdominal cramping Ultram (tramadol) ($15-20 USD)- this is a mild opioid analgesic (it is NOT a controlled substance) that can reduce diarrhoea and reduce pain. It may also provide some of the benefits the antidepressants do. codeine ($ 20 USD)- a very strong anti-diarrhoeal that also provides significant pain relief. A medication like this may be used but typically only intermittently for more severe flare ups. These are benzodiazepines that are mostly used as anxiolytics and/or muscle relaxants. The benzodiazepine chlordiazepoxide is found in Librax and Limbitrol. These may help since anxiety is commonly a contributing factor and they may reduce pain. Typically only used intermittently although if effective long-term use may be appropriate, especially at a low dose. Serax (oxazepam) ($ 17-21 USD) Valium (diazepam) ($ 12-19 USD) Librium (chlordiazepoxide) ($ 18 USD) Ativan (lorazepam) ($ 20 USD) Xanax (alprazolam) ($ 11-13 USD) Over-the-counter medications or supplements won't help you. Also a large number of these medications are NATURAL. It is common to think of pharmaceuticals as synthetic but often they are not. No OTC medication or supplement has any significant evidence it provides any benefit aside from a potential placebo effect. Answered by Carley Abbs 1 year ago.


What is a good medication for paranoia?
So, I have severe anxiety, mild OCD, moderate depression, severe insomnia, and moderate paranoia. I take Xanax/Alprazolam for my anxiety. But I still have paranoia. I see black and white figures of people in my peripheral vision (in the corners of my eyes and all). And sometimes I hear voices yelling either,... Asked by Glinda Blechman 1 year ago.

So, I have severe anxiety, mild OCD, moderate depression, severe insomnia, and moderate paranoia. I take Xanax/Alprazolam for my anxiety. But I still have paranoia. I see black and white figures of people in my peripheral vision (in the corners of my eyes and all). And sometimes I hear voices yelling either, "HEY!" or my name. They're always whisper-y. But I rarely hear voices. I see things quite a bit. I inherited my anxiety and everything from my dad. I'm going through puberty. My dad said the same thing happened to him at almost exactly my age, but it went away. So basically, I'm at this temporary peek of my mental disorders. I'm also constantly, almost like looking for danger? I constantly feel in danger and scared out of my mind. And like I'm haunted with like images of the worst possible occurring all the time. The worst possible scenario. I don't know why. It's like I'm scared for no reason. And I'm so tense and restless. The Xanax helps, but I want to go on a medication for my paranoia. Because everything else is controllable. But the paranoia is the worst. I don't want to go on a ton of psychotic-medications. Is there any? And if so, what are they? THANK YOU. Answered by Vella Stetz 1 year ago.

The Xanax (alprazolam) is controlling the anxiety, OCD, depression, and insomnia? That is very strange, Xanax is only normally effective for anxiety and it may have some antidepressant effects. You should certainly see your doctor (ideally a psychiatrist) about treatments. The only treatment for paranoia and the hallucinations (both auditory and visual) are antipsychotics (neuroleptics) however you probably don't need "a ton of medication." Your psychotic symptoms don't sound too severe and lower doses of medication are likely to be highly effective. Each antipsychotic has some benefits and certain risks. Abilify (aripiprazole) is arguably the most mild antipsychotic, it also has some antidepressant properties, and it comes in dose ranges between 2 mg and 30 mg so you have a better ability to pick a low dose. Risperdal (risperidone) may be good because it may help with depression and it is often very effective for OCD however it has some higher incidence of certain side effects, it is also cheaper. Stelazine (trifluoperazine), although not commonly used, may be good for you. It is effective for anxiety, agitation, psychotic symptoms, and it is dirt cheap. Ideally a small dose (eg., 1-5 mg twice daily would be used. At a higher dose (the maximum is 40 mg/day) the rates of side effects are much higher than they are or most medications. Seroquel (quetiapine) and Seroquel XR (quetiapine extended-release) are good options, it may help with your anxiety, insomnia, and depression. Any antipsychotic should help with with the paranoia, hallucinations, agitation, and to some extent your anxiety. Some may also help with depression, insomnia, or OCD. Also have you spoken with your doctor about using an antidepressant WITH the Xanax to help with the anxiety, agitation, and depression? Symbyax (olanzapine/fluoxetine) may be useful, it combines olanzapine, an antipsychotic commonly known as Zyprexa and fluoxetine, an antidepressant commonly known as Prozac. Limbitrol, Limbitrol DS (chlordiazepoxide/amitriptyline) combines chlordiazepoxide, a benzodiazepine (like Xanax) with the antidepressant amitriptyline. These are just some ideas. If the Xanax is working really well then it is typically not best to change it but the drug Klonopin, Rivotril (clonazepam) and to a smaller extent Ativan (lorazepam) may be better. Both drugs are effective for both anxiety and OCD- Xanax typically is not great for OCD. Klonopin is probably the best benzodiazepine for people with bipolar or psychotic symptoms and it is very effective to reduce agitation, Ativan is great for agitation with anxiety and it is effective for insomnia. If you do stay with the Xanax it may be worth increasing the dose a bit. The other thing that may help a bit is a beta-blocker, typically propranolol or pindolol. These drugs can reduce the PHYSICAL symptoms of anxiety and they really help with restlessness. Pindolol may also help with depression and there is some evidence beta-blockers can help with psychotic symptoms when added to an antipsychotic. Answered by Matt Libera 1 year ago.

Seroquel Paranoia Answered by Colleen Launelez 1 year ago.

You call that "moderate paranoia"? It sounds clinical to me. Xanax will make your paranoia much worse over time, trust me. You should be talking to your dad about how he coped, not looking for chemical answers. I know this sounds weird, but puberty is a MESSED UP TIME, especially for boys. You're supposed to feel crazy. Trying to prevent it sounds really iffy and dangerous. Supressed feelings have a way of returning with a vengeance. Worth considering is exhaustion. Like, running until you don't have the energy to be afraid anymore. Answered by America Mleczynski 1 year ago.

you really need to see a doctor. A small dose of seroquel at night might help or avanza at night but its hard to give advice without more info Answered by Jacquetta Hasty 1 year ago.


CHLORDIAZEPOXIDE: does this medication have a more common name?
Asked by Celia Bonanni 1 year ago.

Its brand names include Librium, Mitran, Poxi, and H-Tran. It is also in combination products. It is combined with clidinium in the drugs Librax, Chlordinium, and Clindex. It is combined with amitriptyline in the drug Limbitrol. Answered by Hermina Marwick 1 year ago.


I have Glaucoma. What medications should I avoid using?
Asked by Lila Houghtelling 1 year ago.

Many Rx & OTC meds say do not take if you have glaucoma. However, it is best to check with your ophthalmologist or pharmacist because you can use some meds even if they say no. Answered by Dorthea Denofrio 1 year ago.

Pantoprazole Answered by Moon Kieke 1 year ago.


Question about tegretol?
I have 3000mg of tegretol; 200mg pills. is this lethal enough? Asked by Noe Dydell 1 year ago.

Sorry. Pl. excuse me. I have no idea. According to Google:- "Tegretol (carbamazepine) is an anticonvulsant. It works by decreasing nerve impulses that cause seizures and pain. Tegretol is used to treat seizures and nerve pain such as trigeminal neuralgia and diabetic neuropathy. Carbamazepine is also used to treat bipolar disorder. Tegretol may also be used for purposes not listed in this medication guide. Important information about Tegretol You should not take Tegretol if you have a history of bone marrow suppression, if you are also taking nefazodone, or if you are allergic to an antidepressant such as amitriptyline (Elavil, Vanatrip, Limbitrol), desipramine (Norpramin), imipramine (Tofranil), or nortriptyline (Pamelor). Besides all the above, my best suggestion is on all such genuine doubts pertaining to mental health, you should strictly follow the good words of advice of a professionally qualified doctor. Other unqualified and non-professional may misguide you or mislead you. Don't believe their words. Answered by Alan Bernardoni 1 year ago.


Acupunture does anyone know if it helps migranes?
I have had migranes for ever does anyone know if acupunture will help ? Asked by Estelle Slemmons 1 year ago.

Hello Fellow Suffer! I feel your pain. YES try it! My Acupuncturist is also an MD! Many insurance co are recognizing this as legitimate treatment. BCBS IL does. I believe wholeheartedly in acupuncture. It helped me quit smoking, relieved a painful muscle spasms in one visit and releases general muscle, neck & TMJ jaw tension & pain which I know staved off my migraines. If that doesn't work try a Chiropractor. There are "trigger points" that have taken a level 7 migraine down to just a "feeling" for me. Currently, I have neck adjustments were neck and head meet. Its incredible! My chiropractor is also certified acupuncturist nutritionist, holistic, ++. Holistic treatment (all parts of the body are interconnected) of illness is never more valid than when it comes to migraines!! Migraines and their triggers differ so much from person to person..and can include potential food allergies. Mine: tension, dehydration, lack of freshwater fresh air, and onions. As for me-15 yrs ago, a great Neurologist turned my "Migraines-6-days-out-of-7-a-week" down to 3 a month. I was sleeping soundly through the night..but because of my stress/tension level, he put me on a "med protocol" for sleeping disorders..A combo of Limbitrol (mild muscle relaxant) at night and Paxil in the morning. It worked immediately- down to 3 the first week. Problem was, I wasn't getting into the deep restorative sleep stage of REM; were the body is asleep (COMPLETELY RELAXED) your mind is awake-dreaming. If you have a lot of stress or tension and dont remember dreams.. check into this. I pray u will find relief. keep searching. Answered by Leone Ficchi 1 year ago.

It is not proven to help by any objective study. Don't confuse anecdotal evidence with actual science. I would recommend keeping a headache journal. Keep track of everything you eat and when as well as when you get headaches or migraines and how bad they are. Most people who have migraines have a "trigger" which is often a food. If you want you can also read some articles online about common non-food triggers and keep track of those as well. If you find your trigger, you can then avoid it in the future. This is a lot of work and may take a month or two before you realize the pattern but it could help you stop your headaches without medicine. Answered by Many Pijanowski 1 year ago.

Drink a soda or tea. It's the caffeine in the medicine that helps alleviate the migraine. If you have taken meds there is nothing to do but wait it out. Lay down in a dark room or put a cloth over your eyes and keep away from loud sounds. Answered by Cordell Battistone 1 year ago.

I'm currently studying acupressure and there are some points that will help relieve migraine pain. It's not a magical cure, but it will help. I linked a picture to two points you can hold on yourself to help dull the pain. Hope I helped, feel better! Answered by America Jefferds 1 year ago.

acupunture helps migranes Answered by Lasonya Mccleave 1 year ago.


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