Application Information

This drug has been submitted to the FDA under the reference 018700/001.

Names and composition

"INOCOR" is the commercial name of a drug composed of INAMRINONE LACTATE.


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Answered questions

What is the dosage of Inocor in CHF?
inamrinone - INOCOR, IV dosage, thanks. Asked by Hal Gottshall 2 years ago.

FDA labeled indications: CHF, acute (short-term treatment). Non-FDA labeled indications: Cardiac surgery/low cardiac output states. Inotropic support (Advance cardiac life support). Dosing (Adult): CHF (short term): initial: 0.75 mg/kg IV bolus over 2-3 min, may repeat in 30 minutes. Maint: 5-10 mcg/kg/min IV infusion. Recommended total daily dose, not to exceed 10 mg/kg. Renal Dosing Renal failure: Crcl<10 ml/min: Administer 50% to 75% of dose. Answered by Dennis Medas 2 years ago.

Nursing School Math Problem: Medication Calculation Problem?
I'm in nursing school and I can't figure this homework problem out: Ordered: Inamrinone (Inocor) 5 mcg/kg/minute. Available: inamrinone 50mg/100 mL normal saline. Patient weighs 135 pounds. Calculate the dosage in milliliters/hour for this patient. Can someone please show me how to set this problem... Asked by Wilton Nolazco 2 years ago.

I'm in nursing school and I can't figure this homework problem out: Ordered: Inamrinone (Inocor) 5 mcg/kg/minute. Available: inamrinone 50mg/100 mL normal saline. Patient weighs 135 pounds. Calculate the dosage in milliliters/hour for this patient. Can someone please show me how to set this problem up and work it out? Thank you!!! I have one other problem similar to this that I will be posting, also. Thanks, again! Answered by Junie Minium 2 years ago.

Since the order is expressed in Kg, first I would determine the patient's weight in Kg: 1. 135lb/2.2 = 61.4Kg Then, I would figure out how much Inocor the patient requires given the ordered amount. The order is 5mcg/kg/min, so the patient needs 5 mcg for every 1Kg he weighs. 2. 5mcg x 61.4Kg = 307mcg/min Next, your available concentration of Inocor is in milligrams (50mg/100mL) so I would convert mcg to mg. There are 1000mcg in 1mg. 3. 307mcg/1000 = 0.307 mg So, the patient requires 0.307mg/min of Inocor. However, the final answer is requested in mL/hour so next, I would figure out how much Inocor the patient requires per hour, instead of per minute. Using the fact that there are 60 minutes per hour: 4. 0.307 x 60 = 18.42mg/hour --> i.e. 0.307mg/min x 60min/hour = 18.42mg/hr Now we know that the patient will be receiving 18.42mg/hour of Inocor, but you need to know how many mL to provide the patient. Since the drug is concentrated to 50mg/100mL (meaning there is 50mg in every 100mL of the drug), you know that this also means there are 5mg/10mL and also that there is 1mg/2mL and further that there is 0.5mg/1mL. It's easiest to figure this question out if you know what the concentration is for every one mL, so going thru this math makes it easier to get to the final answer. Since from our earlier math, we determined that the patient needs 18.42mg/hr we can now figure out how many mL/hour to give. The concentration is 0.5mg/1mL which means there is 0.5mg in every 1mL of the drug. So: 5. 18.42/0.5 = 36.84 --> i.e. 18.42 mg/hr divided by 0.5mg/1mL = 36.84mL/hr or 18.42mg/hr x 1mL/0.5mg = 18.42mg/hr So, the final answer is that you need to give 36.84mL/hour of the concentration 50mg/100mL Inocor to account for the order 5mcg/kg/min in a patient who weight 135 pounds. Hope this helps. This is a very important concept which could account for someone's life. If you don't understand it please spend time with your teacher after class. Answered by Chara Perrigo 2 years ago.

135 pounds converts to 61 kg (135 divided by 2.2).5 mcg/kg would equal 305mcg or 0.305mg/min. That would make 18.3mg/hr.You would round off to 18mg/hr.You have 50mg in 100ml of NS.You would divide 18 by 50 giving you 0.36mls. Multiply that by 100 and you get 36.You would run it at 36mls/hr. Answered by Chrissy Gibson 2 years ago.

Are cardiac glycosides the same as cardiotonics?
I did research on both of them and to me, they have the same mechanism of action and do the exact same thing so I thought they may be the same "group" of drugs but with a different name. But if they're not.... what is another name for cardiotonic drugs? Asked by Beula Bendit 2 years ago.

Inotropics and cardiotonics are medications that increase the strength of the muscle contractions that pump blood from the heart. All cardiac glycosides are cardiotonic drugs. But glycosides are not the only cardiotonic drugs. Cardiotonics are a group with initially mentioned characteristics of which cardiac glycosides are a sub-group. Until recently, the inotropic drug digitalis was the main cardiotonic. Now there are others such as: # Amrinone (Inocor®): A positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator properties, phosphodiesterase inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell. Used in CHF. # Dobutamine (Dobutrex®): Dobutamine is a sympathomimetic drug used in the treatment of heart failure and cardiogenic shock. Its primary mechanism is direct stimulation of β1 receptors of the sympathetic nervous system. # Milrinone (Primacor®): It has positive inotropic, vasodilating and minimal chronotropic effects. It is used in the management of heart failure only when conventional treatment with vasodilators and diuretics has proven insufficient. Answered by Cory Lamport 2 years ago.

What Do Cardiac Glycosides Do Answered by Horace Orengo 2 years ago.

Hello, As we move into the busy holiday season, I hope you’ll take a few minutes to read our latest newsletter. In this edition, I’ve taken a hard look at heart disease and heart attacks, with a close examination of the theories that form the basis of much of today’s treatment. I’m particularly pleased to share with you a report from a dynamic study group in Brazil, If you have any interest in this topic, I think you’ll find the information of great value. As an addition to the newsletter, I’ve included a book review this round, something I’ve been wanting to do for months. I hope you’ll find this useful as well. No holiday season is complete without a cheery and nutritious recipe, this time a very simple but delicious Cranberry sauce. Enjoy! Warmest wishes to you and your family for the holiday and coming year. Tom Cowan Answered by Ara Niederkorn 2 years ago.

yes. They are both positive inotrope drugs which means they both increase the strength of contraction of the heart. You can probably group them as Positive inotropes... I may be wrong about this because its midnight and I'm tired but I believe Cardiotonic drugs (they arent used as far as I know) but they can be grouped with beta 1 adrenergic agonists . sorry probably wasnt any help Answered by Joline Boxwell 2 years ago.

What does noncardiac pulmonary edema do to your body?
Asked by Jacques Maisel 2 years ago.

Non-heart-related pulmonary edema is caused by lung problems like pneumonia, an excess of intravenous fluids, some types of kidney disease, bad burns, liver disease, nutritional problems, and Hodgkin's disease. Non-heart-related pulmonary edema can also be caused by other conditions where the lungs do not drain properly, and conditions where the respiratory veins are blocked. Early symptoms of pulmonary edema include: shortness of breath upon exertion sudden respiratory distress after sleep difficulty breathing, except when sitting upright coughing In cases of severe pulmonary edema, these symptoms will worsen to: labored and rapid breathing frothy, bloody fluid containing pus coughed from the lungs (sputum) a fast pulse and possibly serious disturbances in the heart's rhythm (atrial fibrillation, for example) cold, clammy, sweaty, and bluish skin a drop in blood pressure resulting in a thready pulse Diagnosis A doctor can usually diagnose pulmonary edema based on the patient's symptoms and a physical exam. Patients with pulmonary edema will have a rapid pulse, rapid breathing, abnormal breath and heart sounds, and enlarged neck veins. A chest x ray is often used to confirm the diagnosis. Arterial blood gas testing may be done. Sometimes pulmonary artery catheterization is performed to confirm that the patient has pulmonary edema and not a disease with similar symptoms (called adult respiratory distress syndrome or "noncardiogenic pulmonary edema"). Treatment Pulmonary edema requires immediate emergency treatment. Treatment includes: placing the patient in a sitting position, oxygen, assisted or mechanical ventilation (in some cases), and drug therapy. The goal of treatment is to reduce the amount of fluid in the lungs, improve gas exchange and heart function, and, where possible, to correct the underlying disease. To help the patient breathe better, he/she is placed in a sitting position. High concentrations of oxygen are administered. In cases where respiratory distress is severe, a mechanical ventilator and a tube down the throat (tracheal intubation) will be used to improve the delivery of oxygen. Non-invasive pressure support ventilation is a new treatment for pulmonary edema in which the patient breathes against a continuous flow of positive airway pressure, delivered through a face or nasal mask. Non-invasive pressure support ventilation decreases the effort required to breath, enhances oxygen and carbon dioxide exchange, and increases cardiac output. Drug therapy could include morphine, nitroglycerin, diuretics, angiotensin-converting enzyme (ACE) inhibitors, and vasodilators. Vasopressors are used for cardiogenic shock. Morphine is very effective in reducing the patient's anxiety, easing breathing, and improving blood flow. Nitroglycerin reduces pulmonary blood flow and decreases the volume of fluid entering the overloaded blood vessels. Diuretics, like furosemide (Lasix), promote the elimination of fluids through urination, helping to reduce pressure and fluids in the blood vessels. ACE inhibitors reduce the pressure against which the left ventricle must expel blood. In patients who have severe hypertension, a vasodilator such as nitroprusside sodium (Nipride) may be used. For cardiogenic shock, an adrenergic agent (like dopamine hydrochloride [Intropin], dobutamine hydrochloride [Dobutrex], or epinephrine) or a bipyridine (like amrinone lactate [Inocor] or milrinone lactate [Primacor]) are given. Prognosis Most patients with pulmonary edema who seek immediate treatment can be treated quickly and effectively. ______________________ Answered by Karly Garvis 2 years ago.

Pulmonary edema is literally the deposition of fluid into the alveoli which are the end points of the smallest airways. This fluid prevents the exchange of oxygen and carbon dioxide. Pulmonary edema is a very serious condition which may lead to death in a sense from 'drowning'. Although I do not watch must television I will admit that I enjoy the cerebral Las Vegas CSI which had an episode of death due to altitude related pulmonary edema. Indeed rapid ascent to as little as 10 000 feet (think of the rim of the Grand Canyon) may induce pulmonary edema and I have treated an individual returning from that very circumstance. Answered by Marica Itkin 2 years ago.

This Site Might Help You. RE: What does noncardiac pulmonary edema do to your body? Answered by Leone Markham 2 years ago.

It makes your body retain (keep inside) fluids. It can cause shortness of breath and other breathing problems, that make you tired and weak feeling. You should see a pulmonary (Lung) doctor for that. Answered by Beatris Rion 2 years ago. Above is some great info on the subject, it causes extreme swelling. Answered by Tuyet Gutieres 2 years ago.


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