HERCEPTIN Ressources

Application Information

This drug has been submitted to the FDA under the reference 103792/001.

Names and composition

"HERCEPTIN" is the commercial name of a drug composed of TRASTUZUMAB.
It belongs to the class Antibodies and is used in Antineoplastics (Cancer)

Answered questions

Breast Cancer and Herceptin?
I need a good understandable description of Herceptin. It's for school but the only description I found was unclear to me. Please help. Asked by Pearline Borsellino 4 months ago.

Herceptin is a monoclonal antibody therapy with clinically demonstrated efficacy at disrupting recurrence of malignancy in HER2 positive breast cancer patients. In plain English . . . Herceptin helps prevent a dangerous and all-too-common type of breast cancer from coming back and/or spreading to other parts of the body. See link below for general description from Mayo Clinic. Answered by Christian Cervenak 4 months ago.

Tarkarri has a good explanation. Basically all cells have a protein called HER2 on the outer surface. Some breast cancer cells produce far far too many copies of this protein. The HER2 protein tells a cell when to divide. When there are too many copies of the protein, the cell divides too frequently. Herceptin binds to these proteins on the breast cancer cells, which shuts down the division process. Answered by Zandra Grabner 4 months ago.

Basically, some forms of breast cancer have a protein on their surface that makes them more aggressive and makes them grow faster. Herceptin interferes with this protein to slow, or even stop tumor growth and spread. This site has a fairly clear explanation in Q & A form.. Answered by Teofila Herklotz 4 months ago.


What are the side effects of Herceptin?
Asked by Denise Oris 4 months ago.

Herceptin has some side effects, but the good news is that it doesn't cause the hair loss and nausea associated with most chemotherapy drugs. Mild Side Effects: Herceptin causes flu-like symptoms in about 40% of the women who take it. These symptoms may include fever, chills, muscle aches, or nausea. These side effects generally become less severe after the first treatment. Other side effects, including low white or red blood cell counts, diarrhea, and infections, are seen in some women receiving Herceptin in combination with chemotherapy, but are rarely seen in women taking Herceptin alone. Less commonly, Herceptin can damage the heart's ability to pump blood effectively. Find out more about the benefits and side effects of Herceptin. Rarely (about 5% of the time), the heart damage is bad enough that women experience stroke or life-threatening congestive heart failure—a condition in which the heart can't pump effectively. Slightly more often (about 7% of the time), Herceptin causes mild heart failure. Women who experience mild or more serious heart damage can stop taking Herceptin and start taking heart-strengthening medications. This often brings heart function back to normal. While heart damage can be more severe when Herceptin is given along with other chemotherapy drugs known to cause heart damage, including Adriamycin (chemical name: doxorubicin) and possibly other drugs like it. Taking Herceptin with the chemotherapy drug Taxol (chemical name: paclitaxel) does not increase your risk of severe heart damage. Studies have shown that this combination causes only slightly more mild heart damage than Herceptin alone. Women in clinical trials who are receiving Herceptin plus Taxol are being watched very closely for this effect. For more info see link below Answered by Tula Zorman 4 months ago.

Herceptin has some side effects, but the good news is that it doesn't cause the hair loss and nausea associated with most chemotherapy drugs. Mild side effects Herceptin causes flu-like symptoms in about 40% of the women who take it. These symptoms may include fever, chills, muscle aches, or nausea. These side effects generally become less severe after the first treatment. Other side effects, including low white or red blood cell counts, diarrhea, and infections, are seen in some women receiving Herceptin in combination with chemotherapy, but are rarely seen in women taking Herceptin alone. Serious heart side effects Research News: Preliminary results from the HERA Trial: Herceptin Taken Less Frequently at Higher Doses Does Not Increase Risk of Heart Damage Less commonly, Herceptin can damage the heart's ability to pump blood effectively. Find out more about the benefits and side effects of Herceptin. Rarely (about 5% of the time), the heart damage is bad enough that women experience stroke or life-threatening congestive heart failure—a condition in which the heart can't pump effectively. Slightly more often (about 7% of the time), Herceptin causes mild heart failure. Women who experience mild or more serious heart damage can stop taking Herceptin and start taking heart-strengthening medications. This often brings heart function back to normal. While heart damage can be more severe when Herceptin is given along with other chemotherapy drugs known to cause heart damage, including Adriamycin (chemical name: doxorubicin) and possibly other drugs like it. Taking Herceptin with the chemotherapy drug Taxol (chemical name: paclitaxel) does not increase your risk of severe heart damage. Studies have shown that this combination causes only slightly more mild heart damage than Herceptin alone. Women in clinical trials who are receiving Herceptin plus Taxol are being watched very closely for this effect. Answered by Marilu Eckley 4 months ago.


Herceptin?
what is the effect of herceptin on a tumour? which patients are prescribed it? Asked by Sigrid Grusenmeyer 4 months ago.

Good answer from matador. There is a site www.her2support.org that has a lot of information. Some people get herceptin weekly, others every 3 weeks. Its given by infusion and doesn't have the side effects of chemotherapy. The most serious side effect is the possibility of heart damage. Answered by Twanna Cheeves 4 months ago.

Good answer from matador. The only thing I can add is that my breast cancer was [email protected] positive. I've had the chemo and surgery and am halfway through my radiation. In addition to that I have to get Herceptin once every three weeks for the next year to help prevent the cancer from reoccurring. Answered by Hettie Zollinger 4 months ago.

I also have Her2/neu positive breast cancer. I received Herceptin treatments every week for 18 weeks while going through chemotherapy, and now every three weeks until I have had it for a year. Answered by Jay Crosbie 4 months ago.


After taking herceptin(a type of cancer treatment), can a women have children? Thank you.?
This is a very serious question, please do not put any unecessary comments. Thank you. Asked by Ling Medema 4 months ago.

Herceptin is a genetically engineered drug, developed by Genentech and marketed internationally by Roche, that inhibits reproduction of HER2 positive cancer cells. It's major drawback is a risk of heart damage, which occurs in 3% - 5% of patients. According to Genentech, women should avoid becoming pregnant until 6 months after completing their Herceptin regimen. Herceptin may cause serious damage to a fetus. No other reproductive health related warnings are presented. While Herceptin will not jeopardize your potential for childbearing, there may be other reproductive-related risks associated with your overall condition and treatment plan. Your oncologist may address this matter with you, but you may also wish to consult an ob-gyn. Treating your disease needs to be your top priority, though I appreciate your concerns regarding future motherhood. Because you are a young woman with HER2+ cancer, you are facing a higher risk of recurrence. It is in your best long term interest to utilize all of the treatments recommended by your oncologist. Best wishes for a good long term outcome. Answered by Andy Grieger 4 months ago.

Hmmm. It's unlikely that you would take Herceptin without also receiving adjuvant cytotoxic chemotherapy for breast cancer. With cytotoxic chemotherapy, it depends on the woman's age. The chemotherapy can lead to early menopause which means no more children. The Herceptin might be the least of your concerns. Of course this should be discussed with the oncologist who knows all the details of your situation. You must have an oncologist to receive Herceptin. It is part of his or her job to explain these things to you. Most of my time as an oncologist was spent explaining things like this to patients and family members. Answered by Mariah Eldredge 4 months ago.

You sound like you're an clever lady, so that you will have to be in a position to differentiate what faith dictates and what's cultural or culture. I do not see you doing that considering the fact that you're out to make a factor. Too unhealthy! UPDATE: What you do not appreciate is that Islam could NEVER condone some thing that could reason damage to the human frame or soul. That's only a reality of this fine faith. This isn't what Islam is all approximately. People, Muslims and potentially non-Muslims, have fears, they usually turn out to be placing their religion in God. It's side in their obedience and believe of their author. Sometimes, you're going to see them use the word "depart it to God", which is fine for those who've exhausted all method of repairing it your self. However, many men and women without difficulty stop too quick and upfront placed their believe in God with out making an attempt to do some thing approximately it first. You can debate this difficulty up to you prefer, what's the right frame of mind will also be constantly controversial considering the fact that it includes an detail of religion. This is what God says within the Qur'an: Say: "Nothing will occur to us besides what Allah has decreed for us: He is our protector": and on Allah permit the Believers placed their believe. -Qur'an [nine:fifty one] And men and women need to recall additionally that... There are amongst guys a few who serve Allah, because it had been, at the verge: if well befalls them, they're, therewith, good content material; but when a tribulation involves them, they activate their faces: they lose each this international and the Hereafter: that's loss for all to look! -Qur'an [22:eleven] Answered by Yesenia Aldrich 4 months ago.

As always - who can improve on an answer by Spreedog? What he said. Answered by Jacquetta War 4 months ago.


Is there any pine derivitives in herceptin?
what if any natural herbs or plants are part of the med? Asked by Carmina Ruether 4 months ago.

Herceptin is a bio-engineered monoclonal antibody treatment for HER2 positive breast cancer patients.. There are no pine tree derivatives, herbs, or plants in Herceptin. It is a purely synthetic substance. Answered by Refugia Siem 4 months ago.


Herceptin...?
My 86 year old grandmother found a lump in both breasts, both of which turned out to be malignant....she had a double mastectomy, pulled through amazingly, and did not have any problems at all---the only post-surgery painkiller she wanted/would agree to take was Tylenol. Since surgery she has been on Tamoxifen and... Asked by Adele Kozusko 4 months ago.

My 86 year old grandmother found a lump in both breasts, both of which turned out to be malignant....she had a double mastectomy, pulled through amazingly, and did not have any problems at all---the only post-surgery painkiller she wanted/would agree to take was Tylenol. Since surgery she has been on Tamoxifen and Herceptin (every 3 weeks for a year). However, she recently announced that she is thinking about stopping the Herceptin treatments....every time she gets a Herceptin treatment she feels extremely sick...and she hates it with a passion--she is a very active person, likes to garden, go out with her friends, etc. Basically, its become a quality of life issue. My question is, has anyone else ever had a bad experience with Herceptin; also, is it possible that her doctor could switch treatments to one with more mild side effects?? Thanks for all of your help! Answered by Daphne Cassity 4 months ago.

I am currently on Herceptin treatments. Herceptin is specifically for Her2/neu positive cancer. Tykerb is a more recent drug for Her2/neu+ cancer, but I don't know much about it. She should definitely talk with her oncologist. I haven't had any bad reactions so unfortunately I can't give any advice on that. My very best to her. Answered by Annice Maulin 4 months ago.

everybody reacts differently to every drug! the very best advice I can offer (and I am a 9-year cancer suvivor!) is to ask her oncologist what to do. stopping a treatment w/o consulting the doctor is not a good move! Answered by Vannesa Justice 4 months ago.


Is herceptin good at controlling secondary spine cancer?
Asked by Corliss Branen 4 months ago.

That would depend on the type of cancer....... "Herceptin® (Trastuzumab), as part of a treatment regimen containing doxorubicin, cyclophosphamide, and paclitaxel, is indicated for the adjuvant treatment of patients with HER2-overexpressing, node-positive breast cancer." "In a clinical trial, Herceptin was proven to extend survival in women with HER2+ metastatic breast cancer. As a group, when looking at the entire population of women in this trial, those who received Herceptin plus chemotherapy for HER2+ metastatic breast cancer benefited in important ways. These women lived longer than those who received chemotherapy alone Their cancer was kept from growing for a longer time compared with those who received chemotherapy alone Weekly treatments with Herceptin helped reduce the size of HER2+ breast cancer tumors that had spread to other parts of the body, slowed the return of these tumors,and even lowered their chances of returning Every person who has HER2+ breast cancer is unique, and no cancer treatment works for every person. Your experience may be different from those of the women who participated in the clinical trial." Your oncologist would be in the best position to recommend treatment. Answered by Isaias Bruins 4 months ago.


Heart Faliure and Herceptin?
I had A/C then Taxol and suppose to have a year of Herceptin. After the first two I got CHF. My heart is alot better with the drugs they gave me. They are trying to strengthen my heart so I can have Herceptin. I'm afraid, I hear you can get CHF from Herceptin and I dont want to get any worse. I dont know... Asked by Shantelle Dechamplain 4 months ago.

I had A/C then Taxol and suppose to have a year of Herceptin. After the first two I got CHF. My heart is alot better with the drugs they gave me. They are trying to strengthen my heart so I can have Herceptin. I'm afraid, I hear you can get CHF from Herceptin and I dont want to get any worse. I dont know if it's better to have Herceptin and take that chance since I'm already having heart problems. OR should I say no thanks for Herceptin and be happy with the improvment my heart has made. Answered by Austin Leibowitz 4 months ago.

herceptin can definitely cause CHF but i guess on your part you need to gauge the importance of taking and not taking it.you can take your chance and just treat the CHF as you go and your doc might just stop it all together if it gets really bad but who knows,you might be okay.just make sure you carefully report any more symptoms of shortness of breath and swelling to your doc.goodluck Answered by Veola Bonder 4 months ago.

This is one of those "damned if you do and damned if you don't" situations that are probably the worst things to ever confront in medicine. Do we as health care providers tell a patient to take a drug that can solve one problem knowing full well that it can create another? There are no real answers. Herceptin (in combination with other Chemotherapeutics) has been shown to be more effective in some types of breast cancers and in these cases will definitely prolong life. However, it has also been documented to cause some serious cardiac side effects (most notably failure) that gives a patient and clinician pause. My advice, follow your doctor's suggestions and take the Herceptin with the understanding that you may have to suddenly stop if your cardiac status destabilizes. Obviously, your medical team is already fully aware of the implications. But they also want to give you every chance to fully beat your cancer. I would talk to them and explain your fears about the continued risk of heart failure. Let them show you how they plan to monitor your cardiac status and what they can do if you show signs of failure. In this way, if you're fully aware, and its a collaborative plan of action, it would give you more confidence to go forward with it. Good luck. Ralph Answered by Bethel Stromquist 4 months ago.

I have no idea but want to tell you that you are in my prayers and someone has thought about you! Wish I could answer.. Answered by Suzanna Zorrilla 4 months ago.


Can Herceptin be used for other types of cancer such as brain tumors? since it shrinks breast tumors?
My brother n law has a grade 2 astrocytoma brain tumor that is slow growing but still terminal can this drug be used to shrink the tumor since it is too deep to remove all of it. Asked by Eliseo Molzahn 4 months ago.

Herceptin would only work on cancer cells that overexpress the Her2/neu protein. AFAIK there are no brain cancers that overexpress Her2/neu. I believe ovarian cancer does, and stomach cancer. There are pathology tests they do (ICH and FISH) to test for Her2/neu receptors. One of the distinguishing features of Her2/neu cancer is that it is viciously aggressive ... not slow growing. There are other treatments in clinical trials that have shown some promise for brain tumors. Answered by Rod Ehle 4 months ago.

Herceptin is used in Her2 positive breast cancers and would only help if this were a Her2 positive cancer. Your brother in law’s cancer is an entirely different animal. If this were my family member I would want them to be treated at a facility with a neurosurgical center. I suggest you at least get a second opinion from one. The very best neurosurgeon I know is Keith Black who works out of Cedars-Sinai and UCLA. Dr. Black pioneered research on designing ways to open the blood-brain barrier, enabling chemotherapeutic drugs to be delivered directly into the tumor. He also is developing a vaccine that is in clinical trials that uses cells from the patient’s brain tumor helping the patient’s immune system to fight that particular cancer. He is also a very nice man with a good bedside manner. Answered by Trang Defenderfer 4 months ago.

You and your loved ones chosen to ignore with regard to the professional's suggestion and seek for option therapy. Now whilst that did no longer artwork you're complaining that the docs nevertheless don't understand what they're conversing approximately. evaluating removing chewing gum out of your shoe to removing a tumour contained in the human physique that has been left to advance is merely ridiculous. An oncologist is conscious as plenty approximately maximum cancers because of the fact the doctor. merely because of the fact he/she would not understand a thank you to do the technique does no longer mean they don't understand whilst it somewhat is right to do it or no longer. The maximum cancers has unfold previous the tumour and removing the tumour is obviously unlikely to make plenty distinction. sure, breast maximum cancers is treatable even though it continues to be maximum cancers merely like all the others and left devoid of suited therapy will merely worsen and at last kill you. i'm sorry on your mom and your loved ones and that i unquestionably desire that this became into her determination and he or she wasn't swayed with the help of anybody asserting have not got surgical treatment at a time whilst she became into possibly terrified and searching for any excuse to no longer have it. i understand that any one is entitled to this option (anybody being the affected person and not their family members) yet there is merely too plenty undesirable suggestion accessible on the subject of option remedies and surgical treatment inflicting spreads and so on. each so often we ought to consistently merely believe the folk who understand terrific. I propose that your mom now follows the advice of her oncologist and shall we him/her do in spite of needs to be accomplished to assist lengthen your mom's existence and save her as delicate as conceivable. Answered by Jeanne Delevik 4 months ago.


Herceptin.....?
My grandmother (86) had a double mastectomy in March--she was diagnosed with Her2+ with "little" lymph node involvement. She has been on Herceptin every three weeks since April as well as Tamoxifen daily. Every time she gets a Herceptin treatment she gets extremely sick/put out of commission (she is a... Asked by Odell Sherraden 4 months ago.

My grandmother (86) had a double mastectomy in March--she was diagnosed with Her2+ with "little" lymph node involvement. She has been on Herceptin every three weeks since April as well as Tamoxifen daily. Every time she gets a Herceptin treatment she gets extremely sick/put out of commission (she is a super active old lady) and wants to stop treatment. As a family we're frustrated because we can't find any literature on the side effects of Herceptin among the elderly...and pretty much everything we read says people get along quite well with it. Her oncologist honestly hasn't been any help in this process... Does anyone know where we can find good, scientific info. about Herceptin in the elderly? Also, the experience of anyone who has taken or has a loved one who has taken it would be greatly appreciated. Thanks so much... Answered by Hollis Sefcheck 4 months ago.

I'm sorry to hear your grandmother is having such a hard time. Unfortunately everyone reacts differently with each treatment. Even though many may not have a problem, there is always the small percentage who have a horrible time. I am finishing my last Herceptin treatment this month. Then i've had a full year of it...18 weeks of weekly and the rest every 3 weeks. I have had no adverse side effects from it. I would speak with her oncologist...as he/she should know how horrible she is feeling from it. There may be something she can be given to help with the side effects. I have also heard about a new drug...Tykerb....for Her2/neu+ cancer. I don't have much information on it, but maybe it's worth looking into it. I hope things get easier with your grandmother's treatments. Answered by Kelle Swihart 4 months ago.

Two possible resources breastcancer.org has a section for Her2+ breast cancer patients and there is also a web site called something like HER2+ support - sorry I don't know the URL but you can probably google it. The people there are very informed and responsive. If there is any info on the use of herceptin in the elderly - someone there is going to know about it. I second the suggestion of another responder to consider the possibility of weekly doses instead of 3 week and to also check into what other meds are given. I had the 3 week dose and like most, on the first one I had flu type symptoms, but after that the side effects were minimal - runny nose was the most troublesome. There was a Finnish study (small numbers and it I don't believe that it has been replicated) that showed that something like a 12 week regimen of herceptin was as effective as a year. Sorry I don't have a reference for that either. Answered by Letty Slattery 4 months ago.

I don't know the literature, but if you are interested you can go to www.pubmed.gov.....that's the medical website journal reference that doctors use all the time. I looked to see if there was anything on preventing breast cancer w/ herceptin in the elderly, but nothing came up. I think that your real question is should your grandmother be on it b/c she is suffering from the side effects of the drug. Ok, I just looked for you the most common side effects of the drug include: Chills, fever, nausea, vomiting, weakness and headache were among the most common adverse events in clinical trials and occurred in 40 to 50% of patients during the first infusion of the drug. It does look like herceptin does help improve survival in those patients w/ her2neu+. I'd say have her stick with it, but if she really is suffering a lot from the infusions have her see her doctor to see if there are any other medications that may help her avoid some of the side effects. Best of luck. These drugs are never free of side effects. I know b/c I treat women with gynecological cancers. Answered by Demetra Vacio 4 months ago.

Definitely talk to the doctor about premeds to help with side effects. I get Herceptin every 3 weeks, and only feel a little sleepy on infusion day. No other perceived side effects. They have me take Benadryl and Tylenol to help avoid the most common reactions. If she has nausea, there is no reason for them not to give her Zofran or something else to help with it. Herceptin is truly considered a miracle drug for HER2-NEU positive breast cancer, so I'd do everything in my power to find a way to tolerate it better, rather than discontinuing the treatment. Answered by Nenita Shanno 4 months ago.

Mild side effects Herceptin causes flu-like symptoms in about 40% of the women who take it. These symptoms may include fever, chills, muscle aches, or nausea. These side effects generally become less severe after the first treatment. Other side effects, including low white or red blood cell counts, diarrhea, and infections, are seen in some women receiving Herceptin in combination with chemotherapy, but are rarely seen in women taking Herceptin alone. Serious heart side effects Less commonly, Herceptin can damage the heart's ability to pump blood effectively. Find out more about the benefits and side effects of Herceptin. Rarely (about 5% of the time), the heart damage is bad enough that women experience stroke or life-threatening congestive heart failure—a condition in which the heart can't pump effectively. Slightly more often (about 7% of the time), Herceptin causes mild heart failure. Women who experience mild or more serious heart damage can stop taking Herceptin and start taking heart-strengthening medications. This often brings heart function back to normal. Heart damage can be more severe when Herceptin is given along with other chemotherapy medicines known to cause heart damage, including Adriamycin (chemical name: doxorubicin) and possibly others. Taking Herceptin with the chemotherapy drug Taxol (chemical name: paclitaxel) does not increase your risk of severe heart damage. Studies have shown that this combination causes only slightly more mild heart damage than Herceptin alone. Women in clinical trials who are receiving Herceptin plus Taxol are being watched very closely for this effect. Answered by Viki Ogston 4 months ago.

When I did Herceptin I had very little reactions to it, but it had it weekly instead of every three weeks. What I am wondering is if the dose is significantly higher having it every three weeks. My infusion took about 30 minutes. I would think that is something you might want to ask about. Maybe it wouldn't be as hard on her if she had it weekly. Good luck! Answered by Glennis Kawulok 4 months ago.

Well if she's 86 years old and if she says she don't want to take it anymore, its hard to see anyone we love to say no more, but it becomes quality or quanity of living.. And your family has to decide if you want to watch her be sick all of the time or if you want to let her live what life she has to live doing what she wants??? Its hard I'm sure... And being so active and then being so sick has to be mentally hard for you and your grandma... Check this site out, I'm not sure what there, I just type it in and see what happens, if it don't work try using org behind it instead of .com.. GOOD LUCK!!! Answered by Florida Heinricher 4 months ago.


Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
103792/001 HERCEPTIN TRASTUZUMAB VIAL/ INTRAVENOUS 21MG per ML

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
103792/001 HERCEPTIN TRASTUZUMAB VIAL/ INTRAVENOUS 21MG per ML

Manufacturers

Manufacturer name
Roche Products Ltd

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