Application Information

This drug has been submitted to the FDA under the reference 020357/001.

Names and composition

"GLUCOPHAGE" is the commercial name of a drug composed of METFORMIN HYDROCHLORIDE.

Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
020357/001 GLUCOPHAGE METFORMIN HYDROCHLORIDE TABLET/ORAL 500MG
020357/002 GLUCOPHAGE METFORMIN HYDROCHLORIDE TABLET/ORAL 850MG
020357/003 GLUCOPHAGE METFORMIN HYDROCHLORIDE TABLET/ORAL 625MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
020357/004 GLUCOPHAGE METFORMIN HYDROCHLORIDE TABLET/ORAL 750MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
020357/005 GLUCOPHAGE METFORMIN HYDROCHLORIDE TABLET/ORAL 1GM

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
020357/001 GLUCOPHAGE METFORMIN HYDROCHLORIDE TABLET/ORAL 500MG
020357/002 GLUCOPHAGE METFORMIN HYDROCHLORIDE TABLET/ORAL 850MG
020357/003 GLUCOPHAGE METFORMIN HYDROCHLORIDE TABLET/ORAL 625MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
020357/004 GLUCOPHAGE METFORMIN HYDROCHLORIDE TABLET/ORAL 750MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
020357/005 GLUCOPHAGE METFORMIN HYDROCHLORIDE TABLET/ORAL 1GM
021202/001 GLUCOPHAGE XR METFORMIN HYDROCHLORIDE TABLET, EXTENDED RELEASE/ORAL 500MG
021202/004 GLUCOPHAGE XR METFORMIN HYDROCHLORIDE TABLET, EXTENDED RELEASE/ORAL 750MG
021574/001 FORTAMET METFORMIN HYDROCHLORIDE TABLET, EXTENDED RELEASE/ORAL 500MG
021574/002 FORTAMET METFORMIN HYDROCHLORIDE TABLET, EXTENDED RELEASE/ORAL 1GM
021591/001 RIOMET METFORMIN HYDROCHLORIDE SOLUTION/ORAL 500MG per 5ML
021748/001 GLUMETZA METFORMIN HYDROCHLORIDE TABLET, EXTENDED RELEASE/ORAL 500MG
021748/002 GLUMETZA METFORMIN HYDROCHLORIDE TABLET, EXTENDED RELEASE/ORAL 1GM
075961/001 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 500MG
075961/002 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 850MG
075961/003 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 1GM
075965/001 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 500MG
075965/002 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 850MG
075965/003 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 1GM
075967/001 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 500MG
075967/002 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 850MG
075967/003 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 1GM
075969/001 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 500MG
075969/002 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 850MG
075969/003 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 1GM
075971/001 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 500MG
075971/002 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 850MG
075971/003 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 1GM
075972/001 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 500MG
075972/002 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 850MG
075972/003 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 1GM
075972/004 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 750MG
075972/005 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 625MG
075973/001 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 500MG
075973/002 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 850MG
075973/003 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 1GM
075975/001 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 500MG
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075975/003 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 1GM
075975/004 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 625MG
075975/005 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 750MG
075976/001 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 500MG
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075979/003 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 1GM
075984/001 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 500MG
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075984/003 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 1GM
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076223/001 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET, EXTENDED RELEASE/ORAL 500MG
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076328/001 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 500MG
076328/002 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET/ORAL 850MG
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076450/001 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET, EXTENDED RELEASE/ORAL 500MG
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207427/002 METFORMIN HYDROCHLORIDE METFORMIN HYDROCHLORIDE TABLET, EXTENDED RELEASE/ORAL 750MG

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Answered questions

Can i use glucophage and glibenclamide if i am pregnant?
Asked by David Loisel 1 year ago.

You should not use Glucophage if you are allergic to metformin, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking Glucophage. Before taking Glucophage, tell your doctor if you have liver disease or a history of heart disease. Some people develop lactic acidosis while taking Glucophage. Early symptoms may get worse over time and this condition can be fatal. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired. Before taking Glucophage Some people develop a life-threatening condition called lactic acidosis while taking Glucophage. You may be more likely to develop lactic acidosis if you have liver or kidney disease, congestive heart failure, a severe infection, if you are dehydrated, or if you drink large amounts of alcohol. Talk with your doctor about your individual risk. You should not use Glucophage if you are allergic to metformin, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking this medicine. To make sure you can safely take Glucophage, tell your doctor if you have any of these other conditions: liver disease; or a history of heart disease. FDA pregnancy category B. Glucophage is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether metformin passes into breast milk or if it could harm a nursing baby. Do not take Glucophage without first talking to your doctor if you are breast-feeding a baby. This medicine should not be given to a child younger than 10 years old. Glucophage XR (extended-release) should not be given to a child younger than 17 years old. Answered by Sibyl Cocklin 1 year ago.


If you are taking these medications Glucophage 500 mg and Spironolactone 25 mg?
Will they make you lose weight? I know someone who's been taking them for about a week now and they lost seven pounds and they didn't do anything. They are not on a diet and no type of exercise. Could it be true? Please help! Asked by Terrence Sotiriou 1 year ago.

Glucophage's main use is to treat type 2 diabetes. It acts in two main ways, 1) cuts down on absorption of glucose (sugar) from the gut, 2) it cuts down on the liver's ability to make glucose. Initially, the decreased sugar absorption can cause abdominal bloating, gas and diarrhea. This should subside in about two weeks. Its due to gut bacteria living it up on the sugar that is not absorbed. This is likely the cause of weight loss. In general glucophage is weight neutral. Warning: spironolactone use to be restricted as a diuretic for people with liver disease. Now its use has expanded, for what I think are flimsy reasons. Spironolactone promotes tumors, called lipomas, which are tumors of fat. It likely increases the risk of breast cancer since breast cancer starts out as a lipoma. I once had a patient that had a fatty tumor develop on his face, he had seen two doctor's about it, and neither one knew the cause. It is not the doctor's fault but the drug company that promotes the drug but does not tell anyone about it. Uncontrolled diabetes can cause loss of calories by sugar pouring out in the urine, that can also cause weight loss. I doubt that the diuretic would cause that much weight loss at that dose, if so it would all be water weight. Answered by Ron Hersch 1 year ago.

Spironolactone is a diuretic so if they did lose all of that weight, a good deal of it was probaby as water. Answered by Elissa Koiner 1 year ago.


Glucophage and pregnancy?
My husband and I have been trying to conceive for about 4 months now. I maybe ovulate 3-4 times a year, so I went to my OB/GYN yesterday and he told me that I have polycystic ovarian syndrome. He prescribed me Glucophage, or metformin. He said that there is something that's in Glucophage that while it makes... Asked by Natalia Basket 1 year ago.

My husband and I have been trying to conceive for about 4 months now. I maybe ovulate 3-4 times a year, so I went to my OB/GYN yesterday and he told me that I have polycystic ovarian syndrome. He prescribed me Glucophage, or metformin. He said that there is something that's in Glucophage that while it makes your body produce more insulin, it makes you ovulate. I would like to know how many women have tried this method and did it work for you? How fast did you conceive? Did you stay on it your entire pregnancy? What were any side effects you had? If you have already had your baby, has it effected he or she in any way? Any words would be greatly appreciated. Thank you!! Answered by America Kalil 1 year ago.

Studies show that glucophage is one of the safest ways to increase ovulation for PCOS women. From what I've read, it seems to work within a year or so better than half the time. (That's rather astounding considering that the second-line treatments generally have a 25% or less success rate.) Glucophage is very safe for your baby - it's also a very common medication used to treat blood sugar irregularities (like diabeties), and there have been hundreds of thousands of babies born whose moms took glucophage throughout their pregnancies and who have had no adverse effects. Generally it would be up to your doctor how long you stay on glucophage after you concieve - depending on your own chemistry they may have you stop shortly after, or may have you stay on it until later in the pregnancy, or even after birth. The most common side effect is an upset stomach in the first few weeks of taking it. After the first couple of weeks or so, taking it with milk or with a meal usually helps avoid those sorts of problems. Answered by Cammie Fusha 1 year ago.

re the side effects and potential harm to the baby, I would really recommend asking your doctor to explain them. Good luck. Answered by Lizabeth Lile 1 year ago.


If you take Metformin/Glucophage, what can you do to calm your stomach?
I'm supposed to work my way up to 3 pills a day. This stuff really upsets my stomach. Is there anything I can do to make these pills easier to swallow, so to speak?? Asked by Shelli Nissley 1 year ago.

i would tell the doctor. GENERIC NAME: metformin BRAND NAME: Glucophage , Glucophage XR, Glumetza DRUG CLASS AND MECHANISM: Metformin is an oral medication that lowers blood glucose (sugar) and is used for treating type 2 diabetes. Insulin is a hormone produced by the pancreas that lowers glucose levels in blood by reducing the amount of glucose made by the liver and by increasing the removal of glucose from the blood by muscle and fat tissues. Diabetes results because of reduced production of insulin and reduced uptake (and effects) of insulin on the body's tissues. Metformin acts by increasing the sensitivity of liver, muscle, fat, and other tissues to the uptake and effects of insulin. These actions lower the level of sugar in the blood. Unlike glucose-lowering drugs of the sulfonylurea class, e.g. glyburide (Micronase; Diabeta) or glipizide (Glucotrol), metformin does not increase the concentration of insulin in the blood and, therefore, does not cause excessively low blood glucose levels (hypoglycemia) when used alone. In scientific studies, metformin reduced the complications of diabetes such as heart disease, blindness and kidney disease. Metformin was approved by the FDA in December of 1994. PRESCRIPTION: Yes GENERIC AVAILABLE: Yes PREPARATIONS: Metformin tablets: 500, 850, and 1000 mg. Glucophage XR (extended release) tablets: 500 and 750 mg.� Glumetza tablets(extended release) 500 and 1000 mg. STORAGE: Store at room temperature between 20-25�C (68-77�F). PRESCRIBED FOR: Metformin is used for treating type II diabetes in adults and children. It may be used alone or in combination with other diabetic medications. Metformin also has been used to prevent the development of diabetes in people at risk for diabetes and to treat polycystic ovaries. DOSING: For adults, metformin usually is begun at a dose of 500 mg twice a day or 850 mg once daily. The dose is gradually increased by 500 mg weekly or 850 mg every two weeks as tolerated and based on the response of the levels of glucose in the blood. The maximum daily dose is 2550 mg given in three divided doses. If Glucophage XR tablets are used, the starting dose is 500 mg daily with the evening meal. The dose can be increased by 500 mg weekly up to a maximum dose of 2000 mg once daily or in two divided doses. Glumetza tablets are given once daily.� Metformin should be taken with meals. For pediatric patients 10-16 years of age, the starting dose is 500 mg twice a day. Dosage can be increased by 500 mg weekly up to a maximum dose of 2000 mg. Glucophage XR has not been studied in children. DRUG INTERACTIONS: Cimetidine (Tagamet), by decreasing the elimination of metformin from the body, can increase the amount of metformin in the blood by 40%. This may increase the frequency of side effects from metformin. PREGNANCY: There are no adequate studies in pregnant women. Most experts agree that insulin is the best treatment for pregnant women with diabetes. NURSING MOTHERS: Metformin is excreted into breast milk and can therefore be transferred to the nursing infant. Nursing mothers should not use metformin. SIDE EFFECTS: The most common side effects with metformin are nausea, vomiting, gas, bloating, diarrhea and loss of appetite. These symptoms occur in one out of every three patients. These side effects may be severe enough to cause therapy to be discontinued in one out of every 20 patients. These side effects are related to the dose of the medication and may decrease if the dose is reduced. A serious--though rare--side effect of metformin is lactic acidosis. Lactic acidosis occurs in one out of every 30,000 patients and is fatal in 50% of cases. The symptoms of lactic acidosis are weakness, trouble breathing, abnormal heartbeats, unusual muscle pain, stomach discomfort, light-headedness and feeling cold. Patients at risk for lactic acidosis include those with reduced function of the kidneys or liver, congestive heart failure, severe acute illnesses, and dehydration. Answered by Toshia Knodel 1 year ago.

Metformin is known for causing gastic issues.... let your doctor know. There are alternative medications you can try. Answered by Maurita Kemph 1 year ago.

If it weren't for draconian drug laws you could take a hit off a joint, that would calm your stomach right down. Unfortunately the idiots running this country think it makes you turn into a murderer and a rapist... They watched 'reefer madness' one too many times as children. Answered by Cristen Mask 1 year ago.

A good meal with meat and bread. Just watch your weight Answered by Yahaira Halim 1 year ago.


Can i use glucophage and glibenclamide if i am pregnant?
Asked by Willow Giulian 1 year ago.

You should not use Glucophage if you are allergic to metformin, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking Glucophage. Before taking Glucophage, tell your doctor if you have liver disease or a history of heart disease. Some people develop lactic acidosis while taking Glucophage. Early symptoms may get worse over time and this condition can be fatal. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired. Before taking Glucophage Some people develop a life-threatening condition called lactic acidosis while taking Glucophage. You may be more likely to develop lactic acidosis if you have liver or kidney disease, congestive heart failure, a severe infection, if you are dehydrated, or if you drink large amounts of alcohol. Talk with your doctor about your individual risk. You should not use Glucophage if you are allergic to metformin, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking this medicine. To make sure you can safely take Glucophage, tell your doctor if you have any of these other conditions: liver disease; or a history of heart disease. FDA pregnancy category B. Glucophage is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether metformin passes into breast milk or if it could harm a nursing baby. Do not take Glucophage without first talking to your doctor if you are breast-feeding a baby. This medicine should not be given to a child younger than 10 years old. Glucophage XR (extended-release) should not be given to a child younger than 17 years old. Answered by Ardath Kleckner 1 year ago.


If you are taking these medications Glucophage 500 mg and Spironolactone 25 mg?
Will they make you lose weight? I know someone who's been taking them for about a week now and they lost seven pounds and they didn't do anything. They are not on a diet and no type of exercise. Could it be true? Please help! Asked by Audrey Garnette 1 year ago.

Glucophage's main use is to treat type 2 diabetes. It acts in two main ways, 1) cuts down on absorption of glucose (sugar) from the gut, 2) it cuts down on the liver's ability to make glucose. Initially, the decreased sugar absorption can cause abdominal bloating, gas and diarrhea. This should subside in about two weeks. Its due to gut bacteria living it up on the sugar that is not absorbed. This is likely the cause of weight loss. In general glucophage is weight neutral. Warning: spironolactone use to be restricted as a diuretic for people with liver disease. Now its use has expanded, for what I think are flimsy reasons. Spironolactone promotes tumors, called lipomas, which are tumors of fat. It likely increases the risk of breast cancer since breast cancer starts out as a lipoma. I once had a patient that had a fatty tumor develop on his face, he had seen two doctor's about it, and neither one knew the cause. It is not the doctor's fault but the drug company that promotes the drug but does not tell anyone about it. Uncontrolled diabetes can cause loss of calories by sugar pouring out in the urine, that can also cause weight loss. I doubt that the diuretic would cause that much weight loss at that dose, if so it would all be water weight. Answered by Harold Delang 1 year ago.

Spironolactone is a diuretic so if they did lose all of that weight, a good deal of it was probaby as water. Answered by Norah Eavenson 1 year ago.


Glucophage and pregnancy?
My husband and I have been trying to conceive for about 4 months now. I maybe ovulate 3-4 times a year, so I went to my OB/GYN yesterday and he told me that I have polycystic ovarian syndrome. He prescribed me Glucophage, or metformin. He said that there is something that's in Glucophage that while it makes... Asked by Kizzie Lemmon 1 year ago.

My husband and I have been trying to conceive for about 4 months now. I maybe ovulate 3-4 times a year, so I went to my OB/GYN yesterday and he told me that I have polycystic ovarian syndrome. He prescribed me Glucophage, or metformin. He said that there is something that's in Glucophage that while it makes your body produce more insulin, it makes you ovulate. I would like to know how many women have tried this method and did it work for you? How fast did you conceive? Did you stay on it your entire pregnancy? What were any side effects you had? If you have already had your baby, has it effected he or she in any way? Any words would be greatly appreciated. Thank you!! Answered by Lavelle Kearby 1 year ago.

Studies show that glucophage is one of the safest ways to increase ovulation for PCOS women. From what I've read, it seems to work within a year or so better than half the time. (That's rather astounding considering that the second-line treatments generally have a 25% or less success rate.) Glucophage is very safe for your baby - it's also a very common medication used to treat blood sugar irregularities (like diabeties), and there have been hundreds of thousands of babies born whose moms took glucophage throughout their pregnancies and who have had no adverse effects. Generally it would be up to your doctor how long you stay on glucophage after you concieve - depending on your own chemistry they may have you stop shortly after, or may have you stay on it until later in the pregnancy, or even after birth. The most common side effect is an upset stomach in the first few weeks of taking it. After the first couple of weeks or so, taking it with milk or with a meal usually helps avoid those sorts of problems. Answered by Sue Laughlin 1 year ago.

re the side effects and potential harm to the baby, I would really recommend asking your doctor to explain them. Good luck. Answered by Lola Kuebler 1 year ago.


If you take Metformin/Glucophage, what can you do to calm your stomach?
I'm supposed to work my way up to 3 pills a day. This stuff really upsets my stomach. Is there anything I can do to make these pills easier to swallow, so to speak?? Asked by Loren Dowd 1 year ago.

i would tell the doctor. GENERIC NAME: metformin BRAND NAME: Glucophage , Glucophage XR, Glumetza DRUG CLASS AND MECHANISM: Metformin is an oral medication that lowers blood glucose (sugar) and is used for treating type 2 diabetes. Insulin is a hormone produced by the pancreas that lowers glucose levels in blood by reducing the amount of glucose made by the liver and by increasing the removal of glucose from the blood by muscle and fat tissues. Diabetes results because of reduced production of insulin and reduced uptake (and effects) of insulin on the body's tissues. Metformin acts by increasing the sensitivity of liver, muscle, fat, and other tissues to the uptake and effects of insulin. These actions lower the level of sugar in the blood. Unlike glucose-lowering drugs of the sulfonylurea class, e.g. glyburide (Micronase; Diabeta) or glipizide (Glucotrol), metformin does not increase the concentration of insulin in the blood and, therefore, does not cause excessively low blood glucose levels (hypoglycemia) when used alone. In scientific studies, metformin reduced the complications of diabetes such as heart disease, blindness and kidney disease. Metformin was approved by the FDA in December of 1994. PRESCRIPTION: Yes GENERIC AVAILABLE: Yes PREPARATIONS: Metformin tablets: 500, 850, and 1000 mg. Glucophage XR (extended release) tablets: 500 and 750 mg.� Glumetza tablets(extended release) 500 and 1000 mg. STORAGE: Store at room temperature between 20-25�C (68-77�F). PRESCRIBED FOR: Metformin is used for treating type II diabetes in adults and children. It may be used alone or in combination with other diabetic medications. Metformin also has been used to prevent the development of diabetes in people at risk for diabetes and to treat polycystic ovaries. DOSING: For adults, metformin usually is begun at a dose of 500 mg twice a day or 850 mg once daily. The dose is gradually increased by 500 mg weekly or 850 mg every two weeks as tolerated and based on the response of the levels of glucose in the blood. The maximum daily dose is 2550 mg given in three divided doses. If Glucophage XR tablets are used, the starting dose is 500 mg daily with the evening meal. The dose can be increased by 500 mg weekly up to a maximum dose of 2000 mg once daily or in two divided doses. Glumetza tablets are given once daily.� Metformin should be taken with meals. For pediatric patients 10-16 years of age, the starting dose is 500 mg twice a day. Dosage can be increased by 500 mg weekly up to a maximum dose of 2000 mg. Glucophage XR has not been studied in children. DRUG INTERACTIONS: Cimetidine (Tagamet), by decreasing the elimination of metformin from the body, can increase the amount of metformin in the blood by 40%. This may increase the frequency of side effects from metformin. PREGNANCY: There are no adequate studies in pregnant women. Most experts agree that insulin is the best treatment for pregnant women with diabetes. NURSING MOTHERS: Metformin is excreted into breast milk and can therefore be transferred to the nursing infant. Nursing mothers should not use metformin. SIDE EFFECTS: The most common side effects with metformin are nausea, vomiting, gas, bloating, diarrhea and loss of appetite. These symptoms occur in one out of every three patients. These side effects may be severe enough to cause therapy to be discontinued in one out of every 20 patients. These side effects are related to the dose of the medication and may decrease if the dose is reduced. A serious--though rare--side effect of metformin is lactic acidosis. Lactic acidosis occurs in one out of every 30,000 patients and is fatal in 50% of cases. The symptoms of lactic acidosis are weakness, trouble breathing, abnormal heartbeats, unusual muscle pain, stomach discomfort, light-headedness and feeling cold. Patients at risk for lactic acidosis include those with reduced function of the kidneys or liver, congestive heart failure, severe acute illnesses, and dehydration. Answered by Jacklyn Seldin 1 year ago.

Metformin is known for causing gastic issues.... let your doctor know. There are alternative medications you can try. Answered by Yoshie Waaga 1 year ago.

If it weren't for draconian drug laws you could take a hit off a joint, that would calm your stomach right down. Unfortunately the idiots running this country think it makes you turn into a murderer and a rapist... They watched 'reefer madness' one too many times as children. Answered by Shanta Casana 1 year ago.

A good meal with meat and bread. Just watch your weight Answered by Alyssa Leigland 1 year ago.


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