Application Information

This drug has been submitted to the FDA under the reference 020815/001.

Names and composition

"EVISTA" is the commercial name of a drug composed of RALOXIFENE HYDROCHLORIDE.


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Answered questions

Can you take the drug evista and have lidocaine injected for surgery?
Asked by Tarah String 1 year ago.

lidocaine and Evista (raloxifene) (Minor Drug-Drug) Raloxifene is more than 95% protein bound. Caution should be exercised if raloxifene is coadministered with other highly protein-bound drugs. The mechanism is displacement of the drug from its protein-binding site by raloxifene. Displacement may lead to increased free plasma concentrations and potentiate toxicity of drugs affected by raloxifene. Formal in-vitro studies indicate that raloxifene did not affect the binding of warfarin, phenytoin, or tamoxifen. The clinician may want to use caution when raloxifene is used with other highly-protein bound drugs, such as diazepam, diazoxide, or lidocaine. Basically, what it's saying is, lidocaine may increase the levels of Evista in your blood, or you get more Evista in your system, which may result in more or harsher side effects. But if your having surgery, they know what they are doing. Answered by Wenona Buontempo 1 year ago.

I am now not definite what you're asking, regional anesthesia is as a rule lidocaine (or marcaine) and used always, and the bottles include lidocaine for anesthetic injection-there's no blending or creating a suspension utilizing the ones. Answered by Eldora Pogar 1 year ago.

After taking evista for 5 years for osteoperosis Her2 breast cancer developed. Is Femara the best choice now?
The cancer was removed and had not spread to the lymph nodes. About 6 weeks of radiation was done and now she is ready for the next step. Asked by Yasmine Coswell 1 year ago.

I have not taken Evista. However, I have taken Femara. I was diagnosed with invasive ductal carcinoma in November, 2006. No lymph node involvement so did not have to have chemo or radiation. Did have mastectomy. Since tumor was estrogen/progestone positive and HER2-, and I was post menopausal, I was put on Arimidex first. Terrible side effects, could only tolerate for 6 weeks. Oncologist put me on Femara. Gave it a shot for 4 months. So disabling that I almost ended up in a wheelchair. Also both Arimidex and Femara cause bone density loss and have caused osteoarthritis. Presently I am taking Aromasin which is the third aromatase inhibitor. Has side effects but is tolerable. Also causes bone density loss and many other problems. Go to for specifics on side effects of all these meds. Then talk to your oncologist and make a decision. Answered by Anette Spinoza 1 year ago.

What about herceptin? It's now being used for Stage 1 BC. www. is a great site with lots of info. There is also a herceptin support site (can't remember the exact address). You will get much better answers at either of them. Answered by Simon Schauer 1 year ago.

What tests are required before taking evista (raloxifene)?
Asked by Krishna Peckens 1 year ago.

I believe that you are sort of in the wrong forum, but.... I understand that it is not a good drug for persons prone to blood-clotting... Information is as follows... Brand Name: Evista Generic Name: Raloxifene Hydrochloride [Oral] Pronunciation:......... ra-LOX-if-een .........hye-droe-KLOR-ide Drug class: Selective Estrogen Receptor Modulator (SERM) Generic available? No Controlled substance? No Oral raloxifene hydrochloride belongs to a class of agents called selective estrogen receptor modulators (SERMs). It is used to prevent osteoporosis in postmenopausal women. It works by binding to estrogen receptors. It preserves bone mineral density and increases lipid metabolism while inhibiting breast epithelium and uterine endometrium growth. FDA Approved Uses Used to prevent osteoporosis in postmenopausal women. Contraindications Any of the following may be reason to choose a different drug. Inform your doctor before starting therapy. * Allergic to raloxifene * Known or suspected pregnancy * Active or a past history of venous thromboembolic events, including deep vein thrombosis, pulmonary embolism, and retinal vein thrombosis. Dosage and Administration Dosages may require modification to adjust for individual sensitivities and associated medical conditions. Adults Under 60 * 60 mg taken by mouth once daily without regard to meals. * Take supplemental calcium and vitamin D if daily dietary intake is inadequate. Adults 60 and Over Follow the adult dosage. Infants and Children This drug is not used in this age group. If You Miss a Dose Take as soon as possible. If close to the next dose, skip and take the next dose. Do not double the dose. Storage Keep all medications out of the reach of children Store in a tightly closed container at room temperature in a dry, dark place. Do not store in the bathroom. Moisture can cause the drug to break down. You may experience the following side effects with the use of this drug: Common Symptoms * Leg cramps * Sinusitis (inflammation of the lining of a sinus) * Hot flashes * Less Common to Rare Symptoms * Chest pain * Flatulence (gas) * Fever * Increased coughing * Dyspepsia (upset stomach) * Vaginitis (inflammation of the vagina) * Sweating * Myalgia (muscle pain) * Rash * Migraine * Weight gain * Peripheral edema (swelling of the hands, feet, ankles, due to fluid accumulation) * Nausea or vomiting * Depression Life-threatening Symptoms Thromboembolism or thrombus fornation (coughing blood; loss of or change in speech, coordination, or vision; heart attack; stroke) Possible Overdose Symptoms Overdosage has not been reported What to Do in Case of Overdose In the event of a suspected overdose, dial 911 for emergency help or call your poison control center. All the best! Answered by Homer Roesler 1 year ago.

How does smoking affect the taking of EVISTA?
Asked by Lyndsey Albergotti 1 year ago.

I don't know what Evista is, but smoking will kill you. And it interferes with every medication you take, with your breathing, your arteries, your heart, your lungs, etc., etc. How do I know? I stopped smoking some time ago, but not before I seriously injured my health and ended up with emphysema Answered by Stefany Samano 1 year ago.

Smoking is GROSS! STOP SMOKING! Answered by Alana Avis 1 year ago.

Is there an alternative medicine to Evista?
Evista is so expensive on the new Medicare plan, I just want to know if there is anything else that can replace it. Just what bone work does it do that I can't use something else. Asked by Magdalena Courchene 1 year ago.

Fosamax is an alternative medicine for treating osteoporosis and is taken only 1x a week (as opposed to daily Evista). Your doctor will determine if you can take it because there are certain restrictions (ie, kidney problems etc). Basically these medicines help to reduce bone loss and can even increase the amount of bones in some individuals. You should also consider calcium supplements with Vitamin D. The vitamin D helps in the absorption of calcium. Answered by Rosemarie Feld 1 year ago.

Can evista be taken with strontium for osteoporosis?
Asked by Geoffrey Kirwan 1 year ago.

Your best (and safest) bet would be to ask a pharmacist if there are any interactions listed between the drugs and supplements you're taking. Doctors and pharmacists both have access to a database of drug and supplement interactions and they can tell you quickly if you can safely take them together or not.... anyone here will just have a best guess from searching on the internet (which isn't always accurate, as we all know) ;-) I don't imagine there would be a problem, but I don't have access to that database. I know that Calcium and Strontium shouldn't be taken at the same time because they compete for absorption, but a pharmacist or doctor can say if the Evista would have a similar issue. Good luck and I hope I helped! Answered by Sammy Bongard 1 year ago.

This answer is by no means gospel, and I do not claim it to be true or accurate. As a general disclaimer, please, do not use this information at all, and certainly, check all of these details with your doctor if any of this interests you from a purely academic perspective. Strontium stimulates bone growth and retards bone loss. It seems likely therefore that calcium MUST be taken co-consumately since it is not strontium that is laid down into the new bone, but calcium as usual. Strontium prompts the osteroblasts to generate bone, only a smallish amount becomes incorporated in bone and teeth, although it is significant. It must be taken as part of a well balanced diet. I _vaugely_ remember NICE guidelines recommending very high doses of Calcium and Vitamin D3 as a primer for Strontium therapy. Not sure of this though. Evista is a hormonal treatment. I have not heard of any negative interactions between the two, they operate via different mechanisms. Although, I have heard of numerous negative side-effects of Evista on its own, but not of Strontium. In the UK, Strontium is not a prescribed drug since it does not represent the best economy towards osteoporosis treatment, although I have heard it is very effective (I think) Some private enterprises market strontium supplements. Often this strontium is in the form of inorganic salt, simple salts. These sources of strontium are not as effective as medicinal strontium sources as they have a high clearance from the body. This means the body eliminates the strontium rapidly. Chelating agents are incorporated into the strontium therapy which bind to it and facilitate the body in transporting the strontium to the sites where it is needed, reducing the clearance. Although, the citrate is historically common. Answered by Max Bisher 1 year ago.

Which is the better choice of drugs for Osteoporosis?? Is it Fosamax, Boniva, or Evista?? I am presently on Bo
I am presently on Boniva and was told it is the same classof drugs as Fosamax, and Fosamax has now been proven to give problems with bone (death) of the jaw. I was told Evista would be the only other drug of cchoice for my severe Osteoporis!! Evista is supposedly not a hormone or in the same class (Bisphosphonates)... Asked by Leonardo Finnefrock 1 year ago.

I am presently on Boniva and was told it is the same classof drugs as Fosamax, and Fosamax has now been proven to give problems with bone (death) of the jaw. I was told Evista would be the only other drug of cchoice for my severe Osteoporis!! Evista is supposedly not a hormone or in the same class (Bisphosphonates) as Fosamax or Boniva. Answered by Olin Wythe 1 year ago.

Your doctor is the best guide for this. There was a recent study that Evista can also be a successful phophylaxis for breast cancer in some women. Answered by Jasmine Stollings 1 year ago.

I use to take Fosamax. It was causing chest pain so Dr. switched me to Boniva. Strange, but the Boniva seems to be causing me pain in my upper pallet? Do you have this problem. I can't answer your question, but I'm glad you posted it! I'll sure be watching for an answer! Answered by Mitchell Swabe 1 year ago.

you could talk to your doc about forteo is an injectable...may not be for you, but it never hurts to ask?? what about miacalcin Answered by Ashleigh Kreul 1 year ago.

Does Evista cure Osteoporosis??
My mom has Osteoporosis nd we r both wondering if Evista cures Osteoporosis..if u guys can help me i would really apperciate really worried about her nd i would need ur help to find the answer for that question Asked by Wanita Dickow 1 year ago.

No. Prescriptions merely prevent the body from shedding dead tissue, thus mimicking the appearance of halting bone loss. By harboring dead cells, you are inviting disease - potentially bone cancer. Whole foods and exercise. It's not easy, but it's true. Answered by Rachal Torrez 1 year ago.

No, Evista helps prevent further progression of osteoporosis and can help rebuild some bone. All meds for osteoporosis are made to raise the calcium level in the blood to prevent further bone loss. If the calcium blood level is low, the body breaks down bone. This causes osteoporosis. If the level is normal, you maintain, and if the level is a little high, you will build back some bone. There is a level that is too high, but a slightly above normal level allows the body to build bone. However, adults do not build much bone. So, the osteoporosis will never be cured with todays meds anyways. Just know that many of these meds can have side effects. Dental side effects. Many offer a very, very low risk of osteonecrosis. The bone fails to heal and leaves a large area of dead bone. This is very rare and usually occurs in people who have had cancer treatment. There is a low risk in those who have not had cancer, but only when an infection occurs and usually when a tooth has to be extracted. Just be sure all dental work is up to date and keep it that way. Answered by Season Otterholt 1 year ago.

No. Like most drugs, they don't cure, just suppress or cammoflage the problem. Evista does slow down the bone loss if taken for some time. It's side affects aren't as bad as Boniva and others of the same. I use to take it, but now I take OsteoValen, a natural product, and my doctor says it is working better than Evista and no slight side affects like I use to get. Thought I was having a heart attack when I tried Boniva. Answered by Pasquale Kuman 1 year ago.

Prescription drugs do not cure disease, they merely suppress symptoms. Side effects associated with these drugs can include additional depletion of essential nutrients which can lead to more chronic conditions. A better approach to Osteoporosis would be weight bearing exercise, leafy green vegetables which are high in natural calcium, avoiding sugar and refined foods, and herbs such as horsetail, oatstraw, comfrey, and borage. Answered by Jimmie Cawthron 1 year ago.

Yes your mom can take Evista. It is apply to treat or avoid osteoporosis in postmenopausal women. It is also exploiting to diminish the risk of invasive breast cancer in postmenopausal women who have osteoporosis or who are or else at risk of invasive breast cancer. Answered by Frederick Lachney 1 year ago.

What is the drug Evista used for?
Asked by Kristy Hossfeld 1 year ago.

It's used to treat osteoporosis in post menopausal women. Answered by Emmaline Oberbeck 1 year ago.

"Evista is for the prevention and treatment of women with osterporosis in women past menopause." Basically it helps build bonemass. Answered by Huong Goularte 1 year ago.


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