ETOPOSIDE Ressources

Application Information

This drug has been submitted to the FDA under the reference 074227/001.

Names and composition

"ETOPOSIDE" is the commercial name of a drug composed of ETOPOSIDE.
It belongs to the class Cytotoxics and is used in Antineoplastics (Cancer)

Answered questions

Why does your hair fall out when you take etoposide for chemo?
One of the side effects is your hair falling out when you take the chemo agent etoposide like Lance Armstrong took. Why does your hair fall out? I don't want the "because it's toxic" answer. I want a "the DNA does this or that" answer to why. Is because the cells go through apoptosis... Asked by Han Whidby 3 months ago.

One of the side effects is your hair falling out when you take the chemo agent etoposide like Lance Armstrong took. Why does your hair fall out? I don't want the "because it's toxic" answer. I want a "the DNA does this or that" answer to why. Is because the cells go through apoptosis before they mature? I can handle an answer like that. Thank you Answered by Juanita Ceniceros 3 months ago.

Matt gave an excellent answer. i just wanted to add that I had etoposide in conjunction with carboplaten and the hair loss was my only really significnt side effect. Don't know if I was just lucky but it was nowhere near the trama that I was expecting. I was able to keep working, eat fairly normally and still take part in most of my other activities and interests. I did take a 30min nap most days as well. Answered by Val Notah 3 months ago.

Chemotherapy drugs are systemic poisons. They are the harshest chemicals that we put in our body and call medication. Cancer cells are more metabolically active, so they take up more of these drugs and it causes cell death. Our hair and stomach cells are also more active, so they take up more of the drugs and are more effected than other cells, so we have problems with out stomachs and our hair falls out. Answered by Eura Delpit 3 months ago.


What is the difference between IV etoposide HCl and IV etoposide Phosphate?
Thanks for your help. It turned out that the difference was right in front of me! I think the answer to my questions is that the phosphate version is an ester, therefore it will remain in the inactive form until it is activated in the body. So that explains why only the active form would cause a certain effect and... Asked by Chantay Niedermaier 3 months ago.

Thanks for your help. It turned out that the difference was right in front of me! I think the answer to my questions is that the phosphate version is an ester, therefore it will remain in the inactive form until it is activated in the body. So that explains why only the active form would cause a certain effect and the inactive wouldn't. Answered by Joaquina Forbush 3 months ago.

Very complex question indicating you may be a nurse and/or involved in cancer research. As a medical oncologist, I ordered IV etoposide as VP16 (the common name for the drug in many protocols). I knew it as etoposide phosphate. Vials of 100mg (powder). It was mixed in the pharmacy under a hood. Perhaps a pharmacist will assist you with this question. I have included the best site I could find for the pharmacology of this common cancer chemotherapy agent. ' Hope you get a more useful answer that may help differentiate which form may cause the cracks that you mention. My nurses never mentioned a problem like this to me during the 20 years I was a doctor in this field. Good Luck. Answered by Josette Makinen 3 months ago.

Your best source of information in this respect may be: www.medscape.com There you might find reference to some literature specifically relating to buretrols. Answered by Pearlene Kellie 3 months ago.


Hey i am a medical student , i want to know why etoposide administered before ifosfamide in chemotherapy ?
the professor gave us an assignment to know why IV etoposide should be administered before Ifosfamide , i Tried to search the net for the answer but failed any help ? Asked by Rubin Ranmar 3 months ago.

I found a small article you may want to look at. It's from Medline/ PubMed. I typed in the names of the drugs "etoposide before ifosfamide" and got an answer, It also had and identifying number in case you need it. "PreMedline identifier 1403056 Good luck, hope it helps Answered by Rosalyn Bousquet 3 months ago.


Can chemo make you get a headache?
Ifosfamide and etoposide Asked by Jacinda Estell 3 months ago.

Yes, sometimes drinking lots of water helps. Tell the nurse and see if they can give you anything more or suggest anything else that will help with the headache. Answered by Collen Dagle 3 months ago.

I was diagnosed with cancer in 2006 and I'm 15 years old now. I have been through a lot since then and I'm sorry to tell you that the chemo might make you get not only a headache but other side effects. You can take paracetamol and also tell your doctor about what you're feeling so you'll make sure everything is normal. He might give you something for the side effects rather than paracetamol. Good luck with everything, I hope you'll feel better. Answered by Kirk Caselden 3 months ago.

yes yes :) THESE are their BIG GUNS or at least the IFOS is .. very toxic..My Mother whom is doing great 5 years post lung removal had doxirubison -IFOS combo and hallucinated had horrible FLU like symptoms .. starting on Hour 60 of IV infusion and from that point until WE could get the red and white count up it was bad .. if you need further discussion [email protected] feel free to contact me I don't have a license to protect and can talk TOO you and will bee happy to tell ya that if you only have a headache thank your god Good luck and my thoughts will be with you Answered by Isaac Keene 3 months ago.

Yes... its one of the most commen side effects in nearly all chemo treatments. Answered by Minh Shoe 3 months ago.


What is the drug interaction between etoposide and multivitamins?
Asked by Karan Kubas 3 months ago.

probably Febrile Neutropenia or Pancytopenia Answered by Vennie Redfox 3 months ago.


My son is on the following chemo drugs: Oncovin,Doxorubicin,cytoxan,et... ifosfamide?
he wanted me to ask if anyone knows, when his hair will start falling out. He's 13 and had his 1st treatment, and is not looking forward to his hair loss, i tell him its only hair and will grow back. Asked by Shanice Ayoub 3 months ago.

I would expect his hair to start falling out within 2 weeks of the treatment. It probably will start getting thin then all ths sudden, fall out in big chunks. He will most likely lose his eye brows, eye lashes, and facial hair if he has any yet along with his pubic hair and hair on his arms and legs too. He most likely will develop sun sensitivity and his appetite may diminish greatly. I always tell my pts not to eat their favorite foods while recieving chemo treatments because it will never be there favorite again after they throw it up. Sounds like your sons oncologist is serious here about killing cancer cells. I am curious to know what kind of cancer your son has. This is very aggressive chemotherapy he is recieving. My prayers are with you and you child. Answered by Pearlene Naud 3 months ago.

Everyone is different. My sons hair took a few months to fall out. All his darker hair fell out first and left little blonde wisps for quite awhile. But eventually it all came out. He was on the high dose chemo for 9 months (HD-VAC and Ifosomide/Etoposide). He tolerated treatment very well and had good response from the chemotherapy. Answered by Jazmine Josephs 3 months ago.

Exactly, once the treatment has finished, it will all come back healthy and curly (which the chicks dig) within weeks. Although it seems harsh to have cancer at such a young age it can have it's positive ramifications. The chances of survival are that much greater and it does give a clarity of purpose. Answered by Hee Duryee 3 months ago.

I' m so sorry to here about your son tell him his hair will grow back Answered by Keith Jelsma 3 months ago.

It took my Mom a couple of months before hers fell out. Answered by Refugio Waiters 3 months ago.

Visit the American Cancer Society website. Answered by Myriam Greenlee 3 months ago.


Tomorrow I start my third cycle of ifosfamide and etoposide. How bad will it be?
I have heard each cycle can be worse than the last and now I'm starting to worry Asked by Enrique Szoke 3 months ago.

Not true. You should do just as well or better than you have with cycle 1 and 2. My patients usually did better with cycle 3 because I had figured out what they needed to control symptoms / side effects by then. Every person on chemotherapy is special and different in some way. Answered by Tyesha Kaloustian 3 months ago.

The only way my 3rd cycle of chemo was in any way different was that I started my radiation then. With my 4th cycle my veins decided to not co-operate and it took a few tries to find a vein for the canulla, but my side efffects stayed fairly simillar the whole 6 cycles. I wasn't on ifosfamide, but I was on etoposide and carboplaten. Answered by Genevie Hinckle 3 months ago.


Where does the name VP16 come from?
The chemotherapy agent etoposide is also known as VP16. What is the history of the name VP16? Asked by Patrina Bedient 3 months ago.

Toposar, VePesid, and Etopophos are trade names for Etoposide. VP-16 and Etoposide Phosphate are other names for Etoposide. In some cases, health care professionals may use the trade names Toposar, VePesid, and Etopophos or other names VP-16 and Etoposide Phosphate when referring to the generic drug name Etoposide. Drug type: VP-16 is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. This medication is classified as a "plant alkaloid" and "topoisomerase II inhibitor." Answered by Murray Myall 3 months ago.


How to calculate the volume of a substance when the initial concentration and final concentration are known?
Drug Stock concentration Final concentrationEtoposide 1M 10mMStaurosporine 50mM 250uMTaxol 200uM 500nMYou are provided with a stock concentration of each chemotherapeutic drug above and the final drug concentration required for each treatment. Calculate the volume of each drug added to 1 ml of cells to... Asked by Arielle Hoseman 3 months ago.

Drug Stock concentration Final concentration Etoposide 1M 10mM Staurosporine 50mM 250uM Taxol 200uM 500nM You are provided with a stock concentration of each chemotherapeutic drug above and the final drug concentration required for each treatment. Calculate the volume of each drug added to 1 ml of cells to obtain the desired final concentration. I thought the c1v1=c2v2 formula should be used but not sure when the final volume is not known. Answered by Talisha Jelsma 3 months ago.

All of the dilutions are large, so the volume of drug added to the 1 ml of cells will not add appreciably to the final volume. Etoposide: (x ml)(1 M) = (1 ml)(0.01 M); x = 10 ul or 0.01 ml; so final volume would increase by 1% Staurosporine: (x ml)(50 mM) = (1 ml)(0.25 mM); x = 5 ul; final volume increases by 0.5% Taxol: (x ml)(200 uM) = (1 ml)(0.5 uM); x = 2.5 ul; final volume increases by 0.25% NOW, if they really care about the final volume, and I seriously doubt it, then you can do as follows; I'll do one and you can do the others the same way. You'll see the small, small difference. Etoposide: (x ml)(1 M) = (1+x ml)(0.01M); x = 0.01 + 0.01x; 0.99x = 0.01 and x = 0.0101 ml = 10.01ul Answered by Randy Vaubel 3 months ago.

Kc at this particular temperature is given via Kc= conc(hi)^2/(conc(H2)*conc(I2)) (conc=concentration at equilibrium! = form of moles at equilibrium/complete volume) initially: H2: 2.57 moles I2: 5.20 moles => 2HI: 0 moles After equilibrium: H2: 2.57-a million.22/2 moles= a million.ninety six I2: 5.20-a million.22/2 moles=4.fifty 9 => 2HI: a million.22 moles Fill in : Kc= a million.22^2/(a million.ninety six*4.fifty 9)*(V^2/V*V)=0.1654 Answered by Shantell Postley 3 months ago.


Long Term / Late On-Set Side Effects of Chemo?
I would like to get info from cancer survivors, 2 years or more, if you are experiencing any Long Term / Late On-Set side effects from you Chemo. Mental changes, Cognitive Changes, physical changes, General Health changes, Depression, Anxiety, etc etc...I am not looking for the Side effects during chemo. I am also... Asked by Jeremy Loatman 3 months ago.

I would like to get info from cancer survivors, 2 years or more, if you are experiencing any Long Term / Late On-Set side effects from you Chemo. Mental changes, Cognitive Changes, physical changes, General Health changes, Depression, Anxiety, etc etc...I am not looking for the Side effects during chemo. I am also not looking for answers from people that have not had cancer, unless you were the immediate caregiver and fully aware of any changes after the chemo treatments. I would like to hear personal experiences. I can quote the research, so that is not what I am looking for..Also, I have done exhaustive research on each Chemo drug I was given.. Background: I am 48 year old, male. Diagnosed in June 2011, Surgery on July 2011, Chemo began August 2011, Chemo Completed Dec 2011. 4 cycles of BEP (Bleomycin, Etoposide, Cisplatin). I have done the research about this issue, so please don't sent me to a web site, I think I have read them all, even Medical Briefs on current research on the subject from Major Cancer research centers and hospitals.. Also, I am having tests and other things completed by my Doctor, but as I am sure most of you know, it is a long drawn out process and I am not looking for a diagnosis, personal experiences are what I am looking for.Thanks for the support... Answered by Norman Durtschi 3 months ago.

I had 6 cycles of carboplaten and Etoposide nearly 9 years ago. I still get some lethargy and fatigue and feel less mentally alert. This could just be that I am getting older, working full time and active in the community. :) If it is side effects, then I am happy to put up with them because the chemotherapy gave me the opportunity to get older! Answered by Darwin Cullum 3 months ago.

"Chemotherapy" technically only potential using chemical components to handle ailment. in spite of the undeniable fact that, in prepare, that's usually used to confer with the treatment of maximum cancers with drugs. this is that style of chemotherapy i will describe right here: Chemotherapy is between the optimal procedures maximum cancers is taken care of. It includes giving the affected person drugs to kill the main cancers. some cancers are taken care of with chemotherapy on my own, while in some the chemotherapy is mixed with different remedies, specifically surgical operation or radiation scientific care. Chemotherapy is additionally utilized in circumstances the place the main cancers is incurable, to slow it down, shrink the indications, and lengthen the affected person's existence. a great style of maximum cancers sufferers benefit plenty from chemotherapy- it may treatment the main cancers thoroughly sometimes, allowing sufferers to return to a classic existence, it somewhat is obviously a reliable element. it may, in spite of the undeniable fact that, have significant component-effects, specifically by way of fact maximum chemotherapy drugs will injury universal cells to boot as maximum cancers cells, so that's often fairly unsightly. some sufferers can circulate via chemotherapy with out substantial issues, while others could have fairly a puzzling time of it. customarily, however, the component-effects circulate away while the chemotherapy is stopped. There are fairly some distinctive chemotherapy drugs around, used for various cancers. they could additionally be mixed right into a "chemotherapy recurring" of distinctive drugs, it somewhat is generally extra effective. For the main area, maximum cancers chemotherapy is prescribed by making use of medical doctors stated as oncologists- in some international locations they're stated as "scientific oncologists" to split them from different styles of oncologists (which comprise radiation oncologists, who use radiation). contained while it comes to blood cancers, a physician stated as a "hematologist" must be to blame for prescribing chemotherapy extremely. Answered by Wanita Lorin 3 months ago.

Cut the cost and risk. Smoke and eat cannabis. It will cure it quicker with no damaging effects. look below. god bless. Answered by Jordan Skagerberg 3 months ago.


Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
074227/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074228/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074284/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074290/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074320/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074351/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074510/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074513/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074529/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074813/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074968/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074983/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
075635/001 ETOPOSIDE ETOPOSIDE CAPSULE/ORAL 50MG

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
018768/001 VEPESID ETOPOSIDE INJECTABLE/INJECTION 20MG per ML **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
019557/001 VEPESID ETOPOSIDE CAPSULE/ORAL 50MG
019557/002 VEPESID ETOPOSIDE CAPSULE/ORAL 100MG
074166/001 TOPOSAR ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074227/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074228/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074284/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074290/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074320/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074351/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074510/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074513/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074529/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074813/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074968/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
074983/001 ETOPOSIDE ETOPOSIDE INJECTABLE/INJECTION 20MG per ML
075635/001 ETOPOSIDE ETOPOSIDE CAPSULE/ORAL 50MG

Manufacturers

Manufacturer name
Bristol-Myers Squibb Pharmaceuticals Ltd

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