ERYTHROCIN Ressources

Application Information

This drug has been submitted to the FDA under the reference 050182/002.

Names and composition

"ERYTHROCIN" is the commercial name of a drug composed of ERYTHROMYCIN LACTOBIONATE.

Answered questions

Erythromycin metabolites?
structures and mechanism Asked by Cesar Lew 3 months ago.

erythromycin (ĭrĭth'rōmī'sĭn) , any of several related antibiotic drugs produced by bacteria of the genus Streptomyces (see antibiotic). Erythromycin is most effective against gram-positive bacteria such as pneumococci, streptococci, and some staphylococci (see Gram's stain). The antibiotic also has some effect on gram-negative bacteria and some fungi. Erythromycin inhibits protein synthesis in susceptible microorganisms. It is used to treat such diseases as pneumonia caused by fungi, and streptococcus and syphilis infections, especially where the patient is allergic to penicillin. Most of erythromycin is metabolised by demethylation in the liver. Its main elimination route is in the bile, and a small portion in the urine. Erythromycin's half-life is 1.5 hours. Mechanism of action Erythromycin prevents bacteria from growing, by interfering with their protein synthesis. Erythromycin binds to the 23s rRNA molecule in the 50S of the bacterial ribosome, blocking the exit of the growing peptide chain thus inhibiting the translocation of peptides. structure Erythromycin is a macrolide antibiotic which has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people who have an allergy to penicillins. For respiratory tract infections, it has better coverage of atypical organisms, including mycoplasma. It is also used to treat outbreaks of chlamydia, syphilis, and gonorrhea. Structurally, this macrocyclic compound contains a 14-membered lactone ring with ten asymmetric centers and two sugars (L-cladinose and D-desoamine), making it a compound very difficult to produce via synthetic methods. Erythromycin is produced from a strain of the actinomyces Saccaropolyspora erythraea, formerly known as Streptomyces erythraeus. Answered by Sharice Lambeck 3 months ago.

The macrolides penetrate well into the respiratory, genitourinary, and GI tracts as well as into skin, soft tissues, and sinuses. They are only moderately (40% to 50%) protein-bound. Erythromycin and clarithromycin are mainly metabolized by the liver. The metabolites of erythromycin are excreted in the bile and urine to a small extent. Clarithromycin is metabolized to a pharmacologically active compound, 14-hydroxy clarithromycin, which undergoes renal elimination. This metabolite may be responsible for endowing clarithromycin with its greater efficacy against H influenzae, compared with erythromycin more information if you need you can look into MACROLIDES hope this helps Answered by Broderick Buris 3 months ago.

Whats the question? Answered by Migdalia Limage 3 months ago.

yeah there are a few of them and some are active some aren't. what's the question exactly? Answered by Erika Sedy 3 months ago.


Taking erythromycin during pregnancy?
Asked by Yuette Hippenstiel 3 months ago.

"Erythromycin Pregnancy Warnings Erythromycin crosses the placenta in small amounts. In one study of 11 patients who had detectable erythromycin levels in the serum, 4 infants did not have detectable cord concentrations. The cord concentrations in the remaining 7 infants generally ranged from 1% to 6% of that found in maternal serum. A case of left absence-of-tibia syndrome was reported in an infant whose mother had received erythromycin, ethisterone, and ethinyl estradiol at approximately 4 weeks gestation. Erythromycin has been used prior to delivery in women colonized with group B beta-hemolytic streptococcus to reduce infant colonization. No adverse events in the infants have been reported. Erythromycin has also been used to treat genital Mycoplasma infection during the first trimester without evidence of fetal adverse effects. Pregnant women receiving erythromycin estolate may be more prone to hepatotoxicity. In one study of women receiving erythromycin estolate between the 22nd and 32nd week of pregnancy, 10% showed abnormal levels of SGOT. Erythromycin has been assigned to pregnancy category B by the FDA. Animal studies failed to reveal evidence of teratogenicity. There are no controlled data in human pregnancy. The Centers for Disease Control and Prevention considers erythromycin the drug of choice for treatment of Chlamydia infections in pregnant women. However, erythromycin estolate is considered contraindicated because of drug-related hepatotoxicity. Erythromycin should only be given during pregnancy when need has been clearly established. Erythromycin Breastfeeding Warnings Erythromycin is excreted into human milk in small amounts. Erythromycin is considered compatible with breast-feeding by the American Academy of Pediatrics." Answered by Zoe Buccino 3 months ago.


What are the mechanism of action for erythromycin?
Asked by Candi Rosenkoetter 3 months ago.

"Erythromycin is a macrolide antibiotic produced by Streptomyces erythraeus and was the first of several macrolide antibiotics now on the market. Although erythromycin is active against many microbes, its clinical applications are relatively few" "Mechanism of Action: Erythromycin binds to the 50 S ribosomal subunit, inhibiting bacterial protein synthesis. It is effective against a wide range of microorganisms and, like other antibiotics that inhibit protein synthesis, erythromycin is mainly bacteriostatic. Activity of erythromycin against gram-positive organisms generally is greater than against gram-negative organisms due to its superior penetration into gram-positive organisms. Gram-positive organisms susceptible to erythromycin include Staphylococcus aureus, Streptococcus agalactiae, S. pyogenes, S. pneumoniae, S. viridans group, and Corynebacterium diphtheriae. Gram-negative coverage is limited. In general, erythromycin should not be used against Haemophilus influenzae, although in some cases this organism may be susceptible. Other organisms that have shown susceptibility include Chlamydia trachomatis, Entamoeba histolytica, Listeria monocytogenes, Borrelia burgdorferi (causative agent of Lyme disease), Mycoplasma pneumoniae, Treponema pallidum, and Ureaplasma urealyticum. Clinicians are advised to consult susceptibility data at the institution in which they practice to determine erythromycin's activity. Erythromycin has actions which make it useful outside of the infectious disease field. Erythromycin mimics the effect of the gastrointestinal polypeptide motilin on gastrointestinal motility. This action is probably due to agonism at the motilin receptors. Motilin receptors are found mainly in the gastric antrum and proximal duodenum. The physiologic action produced is an increased motility during the interdigestive (between-meal) period, without affecting postprandial motility. Erythromycin does not affect either dopamine receptors or increase acetylcholine concentrations in the gut." Let me know if this isn't quite it, or more assistance is needed! Janice (email available through my profile) Answered by Jami Bessmer 3 months ago.


Erythromycin?
is it ok for acne? Asked by Hisako Kahana 3 months ago.

Instead of administering ERYTHROMYCIN (Antibiotic) you may try the following and I hope it will be helpful. TOPICAL DRUGS. Treatment for mild noninflammatory acne consists of reducing the formation of new comedones with topical tretinoin, benzoyl peroxide, adapalene, or salicylic acid. Tretinoin is especially effective because it increases turnover (death and replacement) of skin cells. When complicated by inflammation, topical antibiotics may be added to the treatment regimen. Improvement is usually seen in two to four weeks. Topical medications are available as cream, gel, lotion, or pad preparations of varying strengths. They include antibiotics (agents that kill bacteria), such as erythromycin, clindamycin (Cleocin-T), and meclocycline (Meclan); comedolytics (agents that loosen hard plugs and open pores) such as the vitamin A acid tretinoin (Retin-A), salicylic acid, adapalene (Differin), resorcinol, and sulfur. Drugs that act as both comedolytics and antibiotics, such as benzoyl peroxide, azelaic acid (Azelex), or benzoyl peroxide plus erythromycin (Benza-mycin), Or if the acne problem is more you can consult a Skin Doctor. Answered by Adrien Sedlak 3 months ago.

No, it is not good for acne, it is a stronger antibiotic than penicillin and used for strong infections like chlamydia, pneumonia, gonnorhea, etc. Answered by Clarisa Norment 3 months ago.

its an antibiotic so i guess it could be, i know it is used alot to treat ear infections Answered by Suzy Rosenlof 3 months ago.


Can you take erythromycin for a uti ?
Asked by Adrian Fissori 3 months ago.

Erythromycin is a macrolide. Erythromycin is not available on the shelf. You need doctor's prescription after your mid stream urine is tested in the lab for identification and sensitivity testing of the microorganism. Empirically doctor may choose to treat patents without waiting for the lab tests that can take 48 to 72 hours. If the empirical antibiotic given to the patient shows susceptibility to the antibiotic prescribed, the doctor would allow the patient to continue to finish medication. If the lab test results shows that the organism is resistant to the prescribed antibiotic, doctor would ask the patient to stop the earlier prescribed antibiotic and replace it with the one that is effective against the infectious agent. Side effects of Erythromycin include diarrhea and increased risk of heart disease. Therefore be careful before choosing Erythromycin to treat UTI. Do not share antibiotics and do not stop taking them midway; you have to complete the entire course that usually runs for a week to 10 days. Most UTI are caused by E. coli, Klebsiella, Pseudomonas and other Gram negative organisms. Staph aureus, Streptococcus species and yeast also cause UTI and each species of bacteria and yeast have different set of antibacterial & antifungal agents to treat UTI successfully. Empirically Ampicillin, SXT (Septra), Ciprofloxacin and Cloxacin are used for bacterial infection; Fluconazole for yeast. Erythromycin can only be used if the bacterial agent causing UTI is resistant to other antibiotics and/ or if the patient is allergic to Penicillin. Erythromycin is active against Gram positive organisms such as Staph aureus. Erythromycin is insoluble in water and is inactive in acid environment. Answered by Tiffiny Reints 3 months ago.

It depends on the bug that is causing it. Usually if you went to the GP they would give you a course of antibiotics and do a urine test. The course of antibiotics covers most of the common characters. The test will tell you what organism is causing the infection and what antibiotics that organism is sensitive to. Meaning if the original antibiotic was found not to be effective it could be changed quickly. Erythromycin is a macrolide, and is not used as empiric therapy for UTI's. There are much more effective drugs out there. Also by the sounds of it the erythromycin has been prescribed for another reason and you should never start a course of antibiotics off your own back without consulting someone. Best advice is to go see a doctor and get an antibiotic that is likely to work, if they think it's necessary. All the best :) Answered by Reginia Tardy 3 months ago.

Erythromycin For Uti Answered by Oralee Talor 3 months ago.

Yes but i would still see a doctor you may need a different kind of antibiotics Answered by Bethann Sutcliffe 3 months ago.


Is erythromycin for acne?
my derma gave me a togs bar- to cleanse the face. however, it';s not foamy.. ERYTHROMYCIN- to be applied onto whole face.. R&S LOTION- to be applied on areas affected by acne.. what are these? Asked by Aimee Marrano 3 months ago.

Oral Antibiotics - Erythromycin Erythromycin is an antibiotic in the macrolide group and is used in acne treatment. It is the antibacterial and anti-inflammatory effects that are important. If your inflamed pimples do not respond well to topical antibiotics or if you have acne on many areas of your body, acne antibiotics in pill form (oral) can be more effective, easier to take, and more convenient. How Do I Use This Medication? This antibiotic is available both as an oral and a topical acne medication. How Does It Work? It is a bacteriostatic antibiotic, that is, it inhibits the growth of bacteria. It may also have an anti-inflammatory effect. It is useful in the following conditions: Acne Rosacea Perioral dermatitis Pityriasis Lichenoides et Varioliformis Acuta (PLEVA), or Mucha-Habermann disease Erythrasma Erysipelas Erysipeloid Actinomycosis Amebiasis Gonorrhea Chancroid Syphilis Granuloma inguinale Lymphogranuloma venereum virus Will There Be Side Effects? Gastrointestinal upset is common with this acne antibiotic. Rare side effects include: Live toxicity Cardiac toxicity Pancreatitis Ototoxicity(inner ear) in those who have kidney failure The estolate type of erythromycin should be avoided during pregnancy because there is a risk of liver toxicity. Can I Take Other Medications? Avoid astemizole (Hismanol®) and terfenadine (Seldane®, Seldane-D®), which are antihistamines, avoid cisapride (Propulsid®), which is used to treat symptoms of night time heartburn due to gastroesophageal reflux disease. Levels of the following drugs may increase if taken with erythromycin: carbamazepine, valproic acid, warfarin and theophyllin . Which Brands Are Available? Oral: Base - ERYC, E-Mycin Ethylsuccinate - EES® Estolate - Ilosone® (not used in adults) Topical: A/T/S 2-3% Erycette® (Ortho) Erygel® (Allergan) Answered by Rea Houk 3 months ago.

Right now my skin is perfectly clear, for the first time in 3 years. It's been about 9 weeks and all my acne is gone. It is such a great feeling to wake up with clear skin. Holistic Acne Treatment Guide? Answered by Daniele Huson 3 months ago.

Acne is an infection, usually caused by staph aureus, thus antibotic is a logical med, doxycycline & erythromycin are proven common drug of choice. Given at low doses for ar least 6 weeks. Ask you derma about it. Answered by Florrie Medin 3 months ago.

As a teen I had bad acne. I was given an erythromycin 2% topical solution to apply to my face twice daily. It was a miracle drug for me! Answered by Trudy Kreiser 3 months ago.

I used erythromycin for stomach ulcers since I was allergic to Helidac packs and Amox... I guess it's like an antibiotic? Really didn't pay attention to my face but it helped my stomach.. tasted horrible and the pills were HUGE.. but you should have asked the pharmicist before you started taking meds you know nothing about.. so just give them a call Answered by Michelle Strange 3 months ago.

If you have badly harsh acne on your face or on your neck then you should consider Walden' plan Answered by Tyra Schadt 3 months ago.


What are the indications of erythromycin?
Asked by Kittie Hatlee 3 months ago.

Erythromycin is indicated in several bacterial infections. Upper/Lower Respiratory Tract Infection due to mild to moderate infection of Streptococcus infection, Streptococcus pneumoniae, Haemophilus influenza (when used in combination with a sulfonamide antibacterial drug), and mycoplasma pneumoniae. Pertussiis (whooping cough) due to Bordetella pertussis.? May be used for prophylaxis in exposed individuals and for treatment. Diphtheria Erythrasma due to Corynebacterium minutissimum Acute Pelvic Inflammatory Disease due to Neissseria gonorrhoeae for patients sensitive to penicillins. Intestinal Amebiasis due to Entamoeba histolytica Skin and soft tissue infection due to Streptococcus pyogenes and Staphylococcus aureus Primary Syphilis due to Treponema pallidum for patients sensitive to penicillins Infections caused by Chlamydia trachomatis for patients who are unable to tolerate or can not have tetracyclines Prevention of Rheumatic Fever and Bacterial Endocarditis ??????????? The recommended adult dose of erythromycin is 250 mg every 6 hours one hour before meals for ten days.? It is possible to take the drug two times a day by taking 500 mg every 12 hours.? The 333 mg tablet is recommended every 8 hours.? Depending on the severity of the infection, the dose can be increased up to 4 grams per day.? The recommended dose for children is 30-50 mg/kg/day in divided doses Answered by Luciana Freeders 3 months ago.

erythromycin is used for the treatment and prevention of bacterial infections. Answered by Ethelyn Hesse 3 months ago.

they are the good subtitute for penicilins...those who couln"t tolerate peniciline erythtomycine can be given to them.antimicrobial spectra approx same as that of peniclins Answered by Jack Hirsch 3 months ago.

ITS A SUBSTITUTE IF YOU HAVE ALLERGY TO PENICILLIN Answered by Lizeth Collymore 3 months ago.


Can someone tell me about the manufacture process for erythromycin?
Asked by Maryjane Mcdavitt 3 months ago.

Erythromycin is a macrolide antibiotic which has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people who have an allergy to penicillins. For respiratory tract infections, it has better coverage of atypical organisms, including mycoplasma. It is also used to treat outbreaks of chlamydia, syphilis, and gonorrhea. Structurally, this macrocyclic compound contains a 14-membered lactone ring with ten asymmetric centers and two sugars (L-cladinose and D-desoamine), making it a compound very difficult to produce via synthetic methods. Erythromycin is produced from a strain of the actinomyces Saccaropolyspora erythraea, formerly known as Streptomyces erythraeus. Systematic (IUPAC) name 6-(4-dimethylamino-3-hydroxy-6-methyl-... 4-(5-hydroxy-4-methoxy-4,6-dimethyl-ox... 1-oxacyclotetradecane-2,10-dione Identifiers CAS number 114-07-8 ATC code J01FA01 PubChem 3255 DrugBank APRD00953 Chemical data Formula C37H67NO13 Mol. weight 733.93 g/mol Pharmacokinetic data Bioavailability 100% Protein binding 90% Metabolism liver (under 5% excreted unchanged) Half life ? Excretion bile Therapeutic considerations Pregnancy cat. A(AU) B(US) Legal status ℞ Prescription only Routes oral, iv, im Answered by Wilda Villaluazo 3 months ago.


Why would a pregnant woman need to take Erythromycin?
I can only find information for the newborn (eye ointment) and I need to know about the mother. Asked by Regena Gadewoltz 3 months ago.

Erythromycin is an antibiotic that is used often in patients that are allergic to penicillin. It also has a wider variety of usage than penicillin's, and therefor fights more types of bacterial infections. It is a category B medication meaning that it has not been found to cause ill effect to the fetus in pregnant women. Most often prescribed for: Upper respiratory infections, lower respiratory infections, Listerosis, Pertussis, diphtheria, erythrasma, syphilis, intestinal amebbiasis, acute pelvic inflammatory disease, and skin and skin structure infections. "Erythromycins are indicated for the treatment of the following infections caused by Chlamydia trachomatis:conjunctivitis of the newborn, pneumonia of infancy, and urogenital infections during pregnancy. When tetracycline's are contraindicated or not tolerated, erythromycin is indicated for the treatment of uncomplicated urethral, endocervical, or rectal infections in adults due to Chlamydia trachomatis." you would have to ask the patients doctor for specifics. Answered by Rudy Hallio 3 months ago.

I never heard of them giving it to a newborn for eye ointment. I take the pill, and it is for severe skin acne. I was taking it before I became pregnant, my doctor said it is safe to continue to take so I take it. It helps. Some women during pregnancy experience acne so maybe that is why. Answered by Shane Remondet 3 months ago.

I gave my son erytrhomycin and the doctor said it had a lower concentration antibiotic that the eye drops if that helps? Answered by Marty Josey 3 months ago.

It's an antibiotic. So if the pregnant woman had an infection, or is at risk for infection, that would be reason for her to take it. Answered by Allison Grabauskas 3 months ago.

i never knew they should ask ur doc why Answered by Nancey Govern 3 months ago.


Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
050182/002 ERYTHROCIN ERYTHROMYCIN LACTOBIONATE INJECTABLE/INJECTION EQ 500MG BASE per VIAL
050182/003 ERYTHROCIN ERYTHROMYCIN LACTOBIONATE INJECTABLE/INJECTION EQ 1GM BASE per VIAL
050609/001 ERYTHROCIN ERYTHROMYCIN LACTOBIONATE INJECTABLE/INJECTION EQ 500MG BASE per VIAL
050609/002 ERYTHROCIN ERYTHROMYCIN LACTOBIONATE INJECTABLE/INJECTION EQ 1GM BASE per VIAL
062586/001 ERYTHROCIN ERYTHROMYCIN LACTOBIONATE INJECTABLE/INJECTION EQ 500MG BASE per VIAL
062586/002 ERYTHROCIN ERYTHROMYCIN LACTOBIONATE INJECTABLE/INJECTION EQ 1GM BASE per VIAL
062638/001 ERYTHROCIN ERYTHROMYCIN LACTOBIONATE INJECTABLE/INJECTION EQ 500MG BASE per VIAL
062638/002 ERYTHROCIN ERYTHROMYCIN LACTOBIONATE INJECTABLE/INJECTION EQ 1GM BASE per VIAL

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
050182/002 ERYTHROCIN ERYTHROMYCIN LACTOBIONATE INJECTABLE/INJECTION EQ 500MG BASE per VIAL
050182/003 ERYTHROCIN ERYTHROMYCIN LACTOBIONATE INJECTABLE/INJECTION EQ 1GM BASE per VIAL
050609/001 ERYTHROCIN ERYTHROMYCIN LACTOBIONATE INJECTABLE/INJECTION EQ 500MG BASE per VIAL
050609/002 ERYTHROCIN ERYTHROMYCIN LACTOBIONATE INJECTABLE/INJECTION EQ 1GM BASE per VIAL
062563/001 ERYTHROMYCIN ERYTHROMYCIN LACTOBIONATE INJECTABLE/INJECTION EQ 500MG BASE per VIAL
062563/002 ERYTHROMYCIN ERYTHROMYCIN LACTOBIONATE INJECTABLE/INJECTION EQ 1GM BASE per VIAL
062586/001 ERYTHROCIN ERYTHROMYCIN LACTOBIONATE INJECTABLE/INJECTION EQ 500MG BASE per VIAL
062586/002 ERYTHROCIN ERYTHROMYCIN LACTOBIONATE INJECTABLE/INJECTION EQ 1GM BASE per VIAL
062604/001 ERYTHROMYCIN LACTOBIONATE ERYTHROMYCIN LACTOBIONATE INJECTABLE/INJECTION EQ 500MG BASE per VIAL
062604/002 ERYTHROMYCIN LACTOBIONATE ERYTHROMYCIN LACTOBIONATE INJECTABLE/INJECTION EQ 1GM BASE per VIAL
062638/001 ERYTHROCIN ERYTHROMYCIN LACTOBIONATE INJECTABLE/INJECTION EQ 500MG BASE per VIAL
062638/002 ERYTHROCIN ERYTHROMYCIN LACTOBIONATE INJECTABLE/INJECTION EQ 1GM BASE per VIAL
062660/001 ERYTHROMYCIN LACTOBIONATE ERYTHROMYCIN LACTOBIONATE Injectable/ Injection EQ 500MG BASE per VIAL
062660/003 ERYTHROMYCIN LACTOBIONATE ERYTHROMYCIN LACTOBIONATE Injectable/ Injection EQ 1GM BASE per VIAL
062993/001 ERYTHROMYCIN LACTOBIONATE ERYTHROMYCIN LACTOBIONATE INJECTABLE/INJECTION EQ 500MG BASE per VIAL
062993/002 ERYTHROMYCIN LACTOBIONATE ERYTHROMYCIN LACTOBIONATE INJECTABLE/INJECTION EQ 1GM BASE per VIAL
063253/001 ERYTHROMYCIN LACTOBIONATE ERYTHROMYCIN LACTOBIONATE INJECTABLE/INJECTION EQ 500MG BASE per VIAL
063253/002 ERYTHROMYCIN LACTOBIONATE ERYTHROMYCIN LACTOBIONATE INJECTABLE/INJECTION EQ 1GM BASE per VIAL

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