EPHEDRINE SULFATE Ressources

Application Information

This drug has been submitted to the FDA under the reference 208609/001.

Names and composition

"EPHEDRINE SULFATE" is the commercial name of a drug composed of EPHEDRINE SULFATE.

Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
208609/001 EPHEDRINE SULFATE EPHEDRINE SULFATE SOLUTION/INTRAVENOUS 50MG per ML (50MG per ML)

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
208943/001 CORPHEDRA EPHEDRINE SULFATE SOLUTION/IV (INFUSION) 50MG per ML (50MG per ML)
208289/001 AKOVAZ EPHEDRINE SULFATE SOLUTION/INTRAVENOUS 50MG per ML (50MG per ML)
208609/001 EPHEDRINE SULFATE EPHEDRINE SULFATE SOLUTION/INTRAVENOUS 50MG per ML (50MG per ML)

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Answered questions

What is ephedrine sulfate?
its generic name brand name calssification action indication dosages contraindication adverse reactions Asked by Delois Huban 1 month ago.

U.S. Brand Names: Pretz-D® [OTC] Synonyms: Ephedrine Sulfate Generic Available: Yes Use: Treatment of bronchial asthma, nasal congestion, acute bronchospasm, idiopathic orthostatic hypotension Pregnancy Risk Factor: C Lactation: Enters breast milk/not recommended Contraindications: Hypersensitivity to ephedrine or any component of the formulation; cardiac arrhythmias; angle-closure glaucoma; concurrent use of other sympathomimetic agents Warnings/Precautions: Blood volume depletion should be corrected before ephedrine therapy is instituted; use caution in patients with unstable vasomotor symptoms, diabetes, hyperthyroidism, prostatic hyperplasia, or a history of seizures; also use caution in the elderly and those patients with cardiovascular disorders such as coronary artery disease, arrhythmias, and hypertension. Ephedrine may cause hypertension resulting in intracranial hemorrhage. Long-term use may cause anxiety and symptoms of paranoid schizophrenia. Avoid as a bronchodilator; generally not used as a bronchodilator since new beta2 agents are less toxic. Use with caution in the elderly, since it crosses the blood-brain barrier and may cause confusion. Adverse Reactions: Frequency not defined. Cardiovascular: Hypertension, tachycardia, palpitation, elevation or depression of blood pressure, unusual pallor, chest pain, arrhythmia Central nervous system: CNS stimulating effects, nervousness, anxiety, apprehension, fear, tension, agitation, excitation, restlessness, irritability, insomnia, hyperactivity, dizziness, headache Gastrointestinal: Xerostomia, nausea, anorexia, GI upset, vomiting Genitourinary: Painful urination Neuromuscular & skeletal: Trembling, tremor (more common in the elderly), weakness Respiratory: Dyspnea Miscellaneous: Diaphoresis (increased) Overdosage/Toxicology: Symptoms of overdose include dysrhythmias, CNS excitation, respiratory depression, vomiting, and convulsions. There is no specific antidote for ephedrine intoxication and treatment is primarily supportive. Drug Interactions: Alpha- and beta-adrenergic-blocking agents decrease ephedrine vasopressor effects. Cardiac glycosides or general anesthetics may increase cardiac stimulation. MAO inhibitors or atropine may increase blood pressure Sympathomimetic agents: Additive cardiostimulation with other sympathomimetic agents. Theophylline may lead to cardiostimulation. Ethanol/Nutrition/Herb Interactions: Herb/Nutraceutical: Avoid ephedra, yohimbe (may cause CNS stimulation). Stability: Protect all dosage forms from light Compatibility: Stable in dextran 6% in dextrose, dextran 6% in NS, D5LR, D51/4NS, D51/2NS, D5NS, D5W, D10W, LR, 1/2NS, NS Y-site administration: Compatible: Etomidate, propofol. Incompatible: Thiopental Compatibility in syringe: Compatible: Pentobarbital. Incompatible: Thiopental Compatibility when admixed: Compatible: Chloramphenicol, lidocaine, metaraminol, nafcillin, penicillin G potassium. Incompatible: Hydrocortisone sodium succinate, pentobarbital, phenobarbital. Variable (consult detailed reference): Thiopental Mechanism of Action: Releases tissue stores of epinephrine and thereby produces an alpha- and beta-adrenergic stimulation; longer-acting and less potent than epinephrine Pharmacodynamics/Kinetics: Onset of action: Oral: Bronchodilation: 0.25-1 hour Duration: Oral: 3-6 hours Distribution: Crosses placenta; enters breast milk Metabolism: Minimally hepatic Half-life elimination: 2.5-3.6 hours Excretion: Urine (60% to 77% as unchanged drug) within 24 hours Dosage: Children: Oral, SubQ: 3 mg/kg/day or 25-100 mg/m2/day in 4-6 divided doses every 4-6 hours I.M., slow I.V. push: 0.2-0.3 mg/kg/dose every 4-6 hours Adults: Oral: 25-50 mg every 3-4 hours as needed I.M., SubQ: 25-50 mg, parenteral adult dose should not exceed 150 mg in 24 hours I.V.: 5-25 mg/dose slow I.V. push repeated after 5-10 minutes as needed, then every 3-4 hours not to exceed 150 mg/24 hours Nasal spray: Children 6-12 years: 1-2 sprays into each nostril, not more frequently than every 4 hours Children 12 years and Adults: 2-3 sprays into each nostril, not more frequently than every 4 hours Monitoring Parameters: Blood pressure, pulse, urinary output, mental status; cardiac monitor and blood pressure monitor required Test Interactions: Can cause a false-positive amphetamine EMIT assay Patient Education: Use this medication exactly as directed; do not take more than recommended dosage. Avoid other stimulant prescriptive or OTC medications to avoid serious overdose reactions. Store this medication away from light. You may experience dizziness, blurred vision, restlessness (use caution when driving or engaging in tasks requiring alertness until response to drug is known); or difficulty urinating (empty bladder immediately before taking this medication). Report excessive nervousness or excit Answered by Cassidy Pilkenton 1 month ago.

Ephedrine Half Life Answered by Patria Kostenko 1 month ago.


Ephedrine sulfate is a compound better known as a?
decongestant narcotic tranquilizer stimulant Asked by Sheri Datcher 1 month ago.

Ephedrine sulfate is both a decongestant and a stimulant. From Wikipedia... "Ephedrine (EPH) is a sympathomimetic amine commonly used as a stimulant, appetite suppressant, concentration aid, decongestant, and to treat hypotension associated with anaesthesia" Hope this helps!!! Answered by Ouida Tiznado 1 month ago.

is it harmful to your body to take this as a stimulant Answered by Stacy Bann 1 month ago.


After I have my asthma medication I lose all my appetite it has only 2 main ingredients PLEASE HELP!?
Ephedrine Sulfate-25mg Gauffestein-400mg Asked by Babara Magaldi 1 month ago.

u could increase ur appetite any serotonin receptor antagonist as cyproheptadine. Answered by Renato Papantonio 1 month ago.


If someone was given ketorolac tromethamine mixed with ephedrine sulfate and phenalephrine hcl via needle?
what would happen? Asked by Michale Birton 1 month ago.

Hi. These are three very different drugs, with very different effects. Contrary to the statement below, anaesthetists will often use these drugs at the same time to make use of their differing effects. Ketorolac is a potent non-steroidal anti-inflammatory drug (similar to ibuprofen or aspirin, but very much more potent). It is usually given intravenously and is used for the relief of pain associated with tissue inflammation. It is particularly good for ureteric pain (those from renal stones, ureteric stents etc), and in the context of orthopaedic procedures in closed compartments (carpel tunnel and cubital tunnels being the most common). In these circumstances it acts to block the cyclo-oxegenase (I and/or II depending on what books you read) enzyme, which is responsible for the formation of pro-inflammatory mediators via the arachidonic acid cycle. Its side effects are predominately related to platelet aggregation inhibition (which has its own problems, but it much disputed). Ephedrine and Phenylepherine are both pressors, but have subtley differing effects on the cardiovascular system. Phenylepherine is metabolised to a noradrenaline like compound and has predominantly alpha 1 activity, causing peripheral vasoconstriction with no contiguous activity directly on the heart (although a reflex bradycardia is common due to the baroreceptor reflexes). It is particularly useful if the predominant pathology is vasodilatatory in origin (sepsis, anaesthetic drugs etc). Ephedrine is a mixed alpha and beta receptor agonist, and therefore causes an element of peripheral vasoconstriction, but predominantly causes an increase in cardiac inotropicity and an increase in heart rate. Therefore its activity manifests as an increase in stroke volume and heart rate. From this description you can see how an experienced anaesthetist can use all of these drugs at once if he or she chooses. It is important to understand the mechanistics and then be able to apply them together to achieve the desired effects! I hope that helps! Sorry it's a bit long!! Answered by Carlotta Britt 1 month ago.

Blood pressure would go up, and there would be some pain relief for a few hours. Depending on the dose of the two pressors, the blood pressure might go high enough to cause a heart attack or stroke. Those are drugs we use routinely in anesthesia. We don't mix them, though. That would be stupid, because you need to titrate them separately. Answered by Dierdre Golay 1 month ago.


Is ephedrine sulfate the same as ephedrine HCL? Is there a difference?
Asked by Buford Shariat 1 month ago.

They are both salts of ephedrine. Ephedrine sulphate results from reacting sulfuric acid with ephedrine. Hydrochloric acid results in Ephedrine HCL. They are made as salts to be water soluble (and thus medically useful). I don;t know the exact difference, but they do have different pharmacokinetic properties. AKA how fast they are absorbed, metabolized, distributed, and eliminated from the body. Hope that helps. Answered by Lana Weberg 1 month ago.


What is ephedrine and what does it do?
Asked by Mellisa Pahulu 1 month ago.

Ephedrine (EPH) is a sympathomimetic amine similar in structure to the synthetic derivatives amphetamine and methamphetamine. Ephedrine is commonly used as a stimulant, appetite suppressant, concentration aid, decongestant and to treat hypotension associated with regional anaesthesia. Chemically, it is an alkaloid derived from various plants in the genus Ephedra (family Ephedraceae). It is most usually marketed in the hydrochloride and sulfate forms. In traditional Chinese medicines, the herb ma huang (Ephedra sinica) contains ephedrine and pseudoephedrine as its principal active constituents. The same is true of other herbal products containing extracts from Ephedra species. Nagayoshi Nagai was the first one to isolate ephedrine from Ephedra vulgaris in 1885. The substance called soma mentioned in old Hindu books such as the Rig Veda, may have been ephedra extract. This, however, is disputed, as the identity of soma. The production of ephedrine in China has become a multi-million dollar export industry. Companies producing for export extract US$13 million worth of ephedrine from 30,000 tons of ephedra annually, 10 times the amount that is used in traditional Chinese medicine. [edit] Clinical use Ephedrine Sulphate (1932) Ephedrine Compound (1932) and Swan-Myers Ephedrine Inhalant No. 66 (ca. 1940) [edit] Indications Ephedrine was once widely used as a topical decongestant and as a bronchodilator in the treatment for asthma. It continues to be used for these indications, although its popularity is waning due to the availability of more effective agents for these indications which exhibit fewer adverse effects.[4] The role in nasal congestion has largely been replaced by more potent α-adrenergic receptor agonists (e.g. oxymetazoline). Similarly the role of ephedrine in asthma has been almost entirely replaced by β2-adrenergic receptor agonists (e.g. salbutamol). Ephedrine continues to be used intravenously in the reversal of hypotension from spinal/epidural anaesthesia.[4] It is also used in other hypotensive states, including overdose with ganglionic blocking agents, antiadrenergic agents, or other medications that lower blood pressure.[5] It can be used in narcolepsy and nocturnal enuresis. In traditional Chinese medicine, ephedrine has been used in the treatment of asthma and bronchitis for centuries.[6] An ECA stack is a component found in thermogenic weight loss pills, composed of ephedrine, caffeine and aspirin (many supplement manufacturers include salicin instead of aspirin) working to speed up the metabolism and thus cause food energy to burn faster. The ECA stack is a popular supplement taken by body builders before workouts due to the increased amount of energy and alertness. For many years, the US Coast Guard recommended ephedrine together with an equal 25 mg dose of promethazine to its sailors to combat seasickness. Promethazine manages nausea and ephedrine fights the ensuing drowsiness. Commonly referred to as the Coast Guard cocktail, ephedrine may still be available for prescription for this purpose. [edit] Adverse effects Adverse drug reactions (ADRs) are more common with systemic administration (e.g. injection or oral administration) compared to topical administration (e.g. nasal instillations). ADRs associated with ephedrine therapy include:[4] Cardiovascular: tachycardia, cardiac arrhythmias, Angina pectoris, vasoconstriction with hypertension Dermatological: flushing, sweating, acne vulgaris Gastrointestinal: nausea, appetite loss Genitourinary: increased urine output due to increased blood flow (difficulty urinating is not uncommon, as alpha-agonists such as ephedrine constrict the internal urethral sphincter, mimicking the effects of sympathetic nervous system stimulation) Nervous system:restlessness, confusion, insomnia, mild euphoria, mania/hallucinations (rare except in previously existing psychiatric conditions), delusions, formication (may be possible, but lacks documented evidence) paranoia, hostility, panic, agitation Respiratory: dyspnea, pulmonary edema Miscellaneous: dizziness, headache, tremor, hyperglycemic reactions The approved maximum daily dosage of ephedrine for use as a bronchodilator is 150mg, as specified on the packaging of the bronchodilator and expectorant combination, Bronkaid, made by Bayer pharmaceuticals. Overdose can lead to death, although the approved dose is not likely to cause severe reactions when used as directed. Ephedrine can also lead to damage of the brain receptors over a period of high usage; this is because of its constant action on the neurochemicals. It also leads to high increase in blood pressure which over time can lead to damage in the blood vessels. Answered by Marybelle Meiers 1 month ago.


What is the difference between Ephedrine HCL and Ephedrine Sulfate?!?
im not positive if there is any difference, so if anyone could help me, that would be lovely Asked by Shalon Fritsch 1 month ago.

the diff between Ephedrine Hydrochloric Acid (HCL) and Ephedrine Sulfate (SO4) is the parts after Ephedrine ... different elements ... Answered by Tashia Tefera 1 month ago.


Purchasing Ephedra/Ephedrine within the US?
I am interested in obtaining ephedrine to use as a study-aid. I am not 100% sure of it's legality in the U.S. and was wondering if anyone knew of any physical stores (or, preferably, online websites) that you could purchase ephedra or ephedrine-containing products from. I've stumbled across a few websites, but am... Asked by Noriko Emal 1 month ago.

I am interested in obtaining ephedrine to use as a study-aid. I am not 100% sure of it's legality in the U.S. and was wondering if anyone knew of any physical stores (or, preferably, online websites) that you could purchase ephedra or ephedrine-containing products from. I've stumbled across a few websites, but am unsure of their reliability/legality. I am aware of the health risks involved with using Ephedrine. I'm just looking for where (if possible) I can buy it from. I'm not looking for a lecture...I have a mother that can do that. Posted this in diet & weight loss since I thought it'd be the most helpful. Answered by Ivory Marzett 1 month ago.

Any local drugstore - you're looking for a product called Bronkaid. It's kept behind the counter, you'll have to be 18 and let them scan your drivers license in order to buy it. You'll be able to get 60 caplets for about $12-$13; each caplet has 25mg Ephedrine Sulphate and 400 mg Guiafenesin. It's the easiest/cheapest/safest way that I found to get Ephedrine. The law allows you to purchase ephedra products at a rate equivalent to 100mg Ephedrine / day - that means two boxes of bronkaid every month. Trust me, that's enough, even if you're popping it every day (don't). About the guaifenesin - it's a expectorant (helps you cough up mucus). My research led me to conclude that it is relatively benign and safe to take. Please don't take my word for it, research for yourself (for instance, on webmd) and decide whether it's acceptable to consume a medicine you don't want (Guaifenesin) to facilitate semi-recreational use of a stimulant (Ephedra). Answered by Melonie Picou 1 month ago.

The right to bear arms is an indeliable right in this country. Unfortunately, the problem then evolves down to what constitutes an "arm" If you feel that in order to defend yourself and your home you need an automatic weapon, I think that is overkill and perhaps you need to go out to the range and practice somemore. Yeah there is a certain thrill in firing off a magazine/clip as fast as you can, but two or three rounds usually do the trick just as well from stopping someone. That out of the way, the only way I could see the government making it mandatory to have a gun is if we changed the constitution and made everyone a reserve member of the military. Sort of what Switzerland does. As for healthcare, I wish they wouldn't make it mandatory. If you don't want healthcare so be it. But if you get sick, you have to pay the unsubsidized rate and have your wage garnished if you can't afford the bill. Answered by Jaimee Verderame 1 month ago.

Walk into any CVS and pick up Bronkaid. You'll need to show ID. Bronkaid is a decongestant, but it also contains 25 mg of Ephedrine Sulfate. Answered by Letty Monarrez 1 month ago.

"I'm not looking for a lecture...I have a mother that can do that." Then go ask your mother. Answered by Marcelene Catanese 1 month ago.


What is the difference between Pseudo ephedrine Hydrochloride and Pseudo ephedrine Sulfate?
Sudafed and Tavist-D contain Pseudoephedrine Hydrochloride. Claritin-D contains Pseudoephedrine Sulfate. What is the difference between the two decongestants? (I know the antihistimies are different). Asked by Ahmad Mciver 1 month ago.

Their composition and rate of reaction. Also their concentration and strenght of effect. Different may be used in case of allergies/severity/dosage/expense and so on. Answered by Alyce Tuplano 1 month ago.


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