EFUDEX Ressources

Application Information

This drug has been submitted to the FDA under the reference 016831/001.

Names and composition

"EFUDEX" is the commercial name of a drug composed of FLUOROURACIL.

Answered questions

Does efudex cause more cancer?
Asked by Franchesca Beazley 3 months ago.

Unfortunatly right now the only technology we have rght now proven to fight cancers also causes cancer. Its not a guaruntee, but the risk factor is there for this med to cause another type of cancer. My treatment puts me at high risk for a specific type of brain cancer. Irony is, same meds are used to treat that type of brain cancer. Answered by Eladia Zagacki 3 months ago.


Has anyone used efudex cream?
I'm on day 9 and the itching and pain are horrible - the doctor didn't prescribe anything for me for either the pain or itching and I was wondering if anyone else has used this cream and it they were prescribed anything else along with it? Thanks! Asked by Latisha Jackels 3 months ago.

During the first 2 to 4 weeks of treatment, the areas of your skin affected by AK or sBCC lesions will probably turn red and look and feel irritated. This is typical and should not cause concern. The redness, crusting, and peeling are signs that EFUDEX® is working to eliminate the unhealthy cells. Even though this stage of treatment may be unattractive and somewhat uncomfortable, it is important that you do not stop the therapy. Some patients may be concerned with the inflammation associated with EFUDEX® therapy. Talk to your doctor; he or she can best assess the situation and advise you. Areas of your skin where there were no lesions may become red and inflamed. This is because abnormal cells can become inflamed even if the cells were not previously noticeable on the skin's surface.1, 18-20 The more AKs you have, the more redness and inflammation you can expect during treatment. Answered by Isabel Buckholz 3 months ago.

Number 1 about efudex treatment-- you are not in a race. There is no deadline you have to meet. The goal of treatment is not to irritate you; that is a side effect. If the irritation is too much, hold off for 2 to 7 days and give your skin a rest then get back to treatment you will get the job done with a lot less discomfort. Furthermore, over the counter hydrocortisone will not interfere with the beneficial effect of efudex and may also help you tolerate the cream better. If that doesn't do it ask your doctor for a stronger anti-inflammatory cream. I hope these hints help. Answered by Carolee Youngren 3 months ago.

As much as it is painful, plucking is the better option. The chemical option is not only harmful, but could end up being even more painful than plucking, as the coarseness of this hair, and the amount of time it will take for the chemical to work often leaves women with painful burns, which will look even worse than the hair did. In time, plucking will be less painful, and you will not mind it as much. Answered by Darcy Vonwagoner 3 months ago.

One of my friend used efudex cream for the same major problem. it will help to block certain cells in the body. right now her face is very clear. it works fine for her. Answered by Annmarie Parish 3 months ago.

I haven't. SORRY. Answered by Tami Condict 3 months ago.


How to get rid of efudex scars?
My moms friend has efudex, and she has really bad brown spots, and some scabs that she wants to get rid of. I told her just to go to the dermatologist, but she just wants to know if theres a way to get rid of them without going to a dermatologist? Asked by Yanira Balzarine 3 months ago.

there is a way , its a new treatment ,being used but its very expensive ,it comes down to going under a " red " light that burns off the first layer of skin ,takes about a 1/2 hour ,then a " blue " light its very hot ,and burns deeper , they recommend 10 min`s ,a lot of people can only last 5 min`s , however ,after the treatment ,you apply aloe vera ointment to the face for 3 days, and after the blisters start to peel ,you switch to papaya ointment ,this is applied until the swelling ,and scabs have settled then you rub a bio oil in every 3 hours ,her face will go as smooth as a babys bum ,and not a blemish ,but you do not go in direct sunlight with out a hat with a ph rating of 50+, other wise you are right back where you started..but as I say its expensive and can only be done by a qualified Dr...film stars pay up to $1500 dollars for it ,and the pain is intese so think long and hard about it Answered by Illa Alanko 3 months ago.

Nothing will work within 2 weeks, trust me. I have a few scars from various accidents, but the only thing that helps is mederma, it lightens scars, but takes a long time to work. With new scars it will take 4-6 weeks, with old scars it will take 8-12 weeks. If it works. Answered by Dagmar Salberg 3 months ago.


Efudex and alcohol-interactions?
Hi: I know that this is a topical cream but I want to make sure that it does not have any interactions with alcohol. Could someone please let me know. Thanks so much Asked by Louella Torok 3 months ago.

I wouldn't think so but check with your doctor or dermatologist just in case. Answered by Xiao Happel 3 months ago.

Call your pharmacist. GOOD LUCK. Answered by Kristopher Sadow 3 months ago.


Cheapest place to buy prescription efudex?
with or without a prescription Asked by Stefanie Clause 3 months ago.

some obscure remote hot village drug store in mexico,.. check expiration date no refunds. Answered by Erich Brucie 3 months ago.


Has anyone ever been on Efudex?
I want opinions please. I have all the links to the sites and want to know what the opinion is of people who have been on the medication. Asked by Providencia Mikell 3 months ago.

www.google.com has a great deal of information that you could use to find your answers , while yahoo answer is more likely to be better for people's opinions.. thanks. Answered by Mariano Belleau 3 months ago.


I am starting to use Efudex precancer cream. I know my whole face will soon be a mess?
Its going to be embarresing to go out in public, as I have to apply it to my whole face. Can I put on makeup just long enough to go out to the store etc? Asked by Darci Cygrymus 3 months ago.

To answer your first question; your skin probably wont become a mess. To quote the manufacturers: "The pattern of normal therapeutic response to Efudix follows a sequence of erythema, vesiculation, erosion, ulceration and necrosis followed by epithelialisation, without damaging normal skin. Therefore, the appearance of the lesions may initially be worse prior to resolution." This means that the nasty side effects redness (erythema), formation of blisters (vesiculation) etc. only occur on lessions, i.e. areas of cancer and perhaps precancer as well. If this happens its a case of the skins appearance getting worse before the skin heals itself. The healthy skin may become red for a while too but should calm down. Sometimes when this happens to normal skin it is made worse by sunlight so if your skin starts to get red try to avoid sunlight. Also I know a few patients on it and they haven't had any problems with it. Second question; should you feel you need to put makeup on I would be concerned about the makeup increasing the absorption of effudix, which could lead to side effects, if you want to wear makeup allow at least two to three hours between applying the efudix and applying makeup. Answered by Katelin Zmiejko 3 months ago.


Skin cancer chemo...and hair loss.?
Sorry....the drug is called Efudex. Asked by Louie Clise 3 months ago.

Wish you had given name of the medicine. He may lose hair if it is a cyto-toxic drug. But hair will regrow when therapy is over. Good luck for your dad! Answered by Temika Cotto 3 months ago.


What do you know about dysplasia?
Around 1992 I had a hysterectomy due to PID (pelvic inflammatory disease) and the doc also found severe endometriosis. In 2000 I had 'beyond' severe dysplasia, I believe it was very early stage of cancerous. For 10 weeks I had to use Efudex 7 to treat this. This was a vaginal cream insertion on a daily... Asked by Fernando Borowiak 3 months ago.

Around 1992 I had a hysterectomy due to PID (pelvic inflammatory disease) and the doc also found severe endometriosis. In 2000 I had 'beyond' severe dysplasia, I believe it was very early stage of cancerous. For 10 weeks I had to use Efudex 7 to treat this. This was a vaginal cream insertion on a daily basis. After a few days I noticed a discharge that was beyond anything I had ever had. I would become every morning shortly after each treatment so I called the pharmacist to inquire. I was told this was a chemo treatment. I had no idea! Anyway time moves on and I have to have paps every 3-6 months depending on what result the OBGYN-Oncologist finds. Dysplasia is always there, varying from mild to moderate. All of these problems have been going on for 18 years. This concerns me. I have a rheumatoid disease, Sjogren's Syndrome/Lupus, which keeps my immunity down. My WBC is always low. I am 47 and factoring that in is in my mind as well. Also, a few years back my blood counts were so haywire the State got hold of them, b/c of my T-cell results the guy was insistent of gaining info on my HIV status. ???? I don't have HIV. My information was placed with the state. Bottom line, how concerned should I be? I keep hearing that routine Paps aren't as accurate as they should be. I have colposcopy's about every other time I visit the Oncologist. Answered by Gavin Pesta 3 months ago.

You are throwing in a lot of extra information. Pap smears are very good. There is no sharp line between dysplasia and neoplasia which is cancer. If the dysplasia invades the basement membrane it is called cancer. If it hasn't done that yet, it is called Carcinoma in situ. It is believed that if Ca in situ is left untreated it will progress to cancer eventually. You were treated with Efudex which is chemotherapy and burns the abnormal tissue causing a discharge of dead tissue. You also have colposcopies which means the doctor is doing his job of looking for evidence of spread of the abnormal tissue. Regular pap smears and colposcopies is the way of monitoring the dysplasia so if it is seen to invade the basement membrane you can get further treatment. To me it sounds like you are in the hands of a good OB-GYN. He is keeping a close eye on your condition. You haven't said what the T-cell test showed beyond the fact that you are HIV negative. Your connective tissue diseases would seem to be separate and unrelated. I would say that you can rest easy knowing you are in the hands of a good MD. This is not to say that bad things cannot happen unpredictably, but that is the same boat we are all in. Answered by Damaris Fendley 3 months ago.

OK, let me explain hips to you. Your vet will ex-ray your dog's hips then send the ex-rays to the BVA hip scoring panel for evaluating. The panel will study the fits and angles of 9 separate features of the hip and award marks to each. 8 of the features are awarded marks between 0 and 6 but for some reason the 9th feature is only awarded marks between 0 and 5. (Low marks good, high marks bad) If you like to count these up you will find that the maximum possible score is 53 for each side, 106 in total. You can think of it like this, 0 means the hip is perfect and 53 means it effectively has no hip on that side at all. Hip scores are traditionally referred to in the form of 4/6 (4 being the score of the right hip and 6 being the score of the left hip) or it can also be referred to as 10 total (4+6=10) Over the years the scores of the dogs within the different breeds have been recorded so the average score of dogs within each breed is known. In Labradors, the latest figure as of 1/1/06 is 15 total (this is actually not the average, rather the "Mean" but is as near the average as makes no difference) This mean score, because it include ALL Labradors ever scored does not really show the direction the scores are moving, are they getting worse? Or better? And if so how much worse or better? So in order to convey a feel for the directing things are heading, the BVA give us another figure, the Median, and the median in Labradors is 10, this figure giving a better idea of the average scores which have been awarded in more recent times. So, getting on to the sire and dam of your dog 8 and 4 respectively, these are very good scores, well below the mean and even below the median! Very nice! Hope that explains things for you, but if you have any further questions just say and I'll try to explain things further. Regards, John Answered by Antonetta Mccooey 3 months ago.

How in the world could you have cancer and not know it? You either need better discussions with your oncologist or get another one. There is no way to answer you not knowing what your history is. Answered by Shaunta Kiel 3 months ago.


Hi does anybody know the dangers of swallowing efudix (chemotherapy cream)?
I had to use this several months ago and swallowed some over the first 5-6 days which caused a sore burning throat and the taste of a dead rotting animal in my mouth which literally made me heave, since around about that time I have had a very bad aching chest/lung to the left hand side that is almost constant with... Asked by Wilfredo Kirsch 3 months ago.

I had to use this several months ago and swallowed some over the first 5-6 days which caused a sore burning throat and the taste of a dead rotting animal in my mouth which literally made me heave, since around about that time I have had a very bad aching chest/lung to the left hand side that is almost constant with just a few times when the pain has abated. I was wondering if this cream could have caused any serious problems and I can't find any information on this any where so I am hoping someone can help me with this. Many thanks in advance for taking the time to read this. Jo x Answered by Virgil Steinharter 3 months ago.

Efudex Cream is just 5FU - one of our mildest and most rapidly metabolized chemotherapy agents. You had the irritating mucosal effects over the first few days. There should be no long term effects in the lungs. I assume you swallowed only a very small amount accidentally. Answered by Andre Granados 3 months ago.

Call 1-800-222-1222 for Poison Control. They can tell you. Alternately, talk to your doctor. Answered by Candace Manaker 3 months ago.


Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
016831/001 EFUDEX FLUOROURACIL SOLUTION/TOPICAL 2%
016831/002 EFUDEX FLUOROURACIL SOLUTION/TOPICAL 5%
016831/003 EFUDEX FLUOROURACIL CREAM/TOPICAL 5%

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
012209/001 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 500MG per 10ML (50MG per ML) **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
012209/002 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 2.5GM per 50ML (50MG per ML)
016765/001 FLUOROPLEX FLUOROURACIL SOLUTION/TOPICAL 1%
016831/001 EFUDEX FLUOROURACIL SOLUTION/TOPICAL 2%
016831/002 EFUDEX FLUOROURACIL SOLUTION/TOPICAL 5%
016831/003 EFUDEX FLUOROURACIL CREAM/TOPICAL 5%
016988/001 FLUOROPLEX FLUOROURACIL CREAM/TOPICAL 1%
017959/001 ADRUCIL FLUOROURACIL INJECTABLE/INJECTION 50MG per ML
020985/001 CARAC FLUOROURACIL CREAM/TOPICAL 0.5%
022259/001 TOLAK FLUOROURACIL CREAM/TOPICAL 4%
040023/001 ADRUCIL FLUOROURACIL INJECTABLE/INJECTION 50MG per ML
040278/001 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 2.5GM per 50ML (50MG per ML)
040278/002 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 5GM per 100ML (50MG per ML)
040279/001 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 1GM per 20ML (50MG per ML)
040279/002 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 500MG per 10ML (50MG per ML)
040291/001 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 50MG per ML
040333/001 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 500MG per 10ML (50MG per ML)
040334/001 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 2.5GM per 50ML (50MG per ML)
040334/002 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 5GM per 100ML (50MG per ML)
040379/001 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 50MG per ML
040743/001 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 1GM per 20ML (50MG per ML)
040743/002 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 500MG per 10ML (50MG per ML)
040772/001 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 500MG per 10ML (50MG per ML)
040798/001 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 5GM per 100ML (50MG per ML)
040798/002 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 2.5GM per 50ML (50MG per ML)
076526/001 FLUOROURACIL FLUOROURACIL SOLUTION/TOPICAL 2%
076526/002 FLUOROURACIL FLUOROURACIL SOLUTION/TOPICAL 5%
077524/001 FLUOROURACIL FLUOROURACIL CREAM/TOPICAL 5%
081222/001 ADRUCIL FLUOROURACIL INJECTABLE/INJECTION 50MG per ML
081225/001 ADRUCIL FLUOROURACIL INJECTABLE/INJECTION 50MG per ML
087791/001 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 50MG per ML
087792/001 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 50MG per ML
088766/001 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 50MG per ML
088767/001 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 50MG per ML
088929/001 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 50MG per ML
089152/001 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 50MG per ML
089368/001 FLUOROURACIL FLUOROURACIL Injectable/ Injection 50MG per ML
089428/001 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 50MG per ML
089434/001 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 50MG per ML
089455/001 FLUOROURACIL FLUOROURACIL Injectable/ Injection 50MG per ML
089508/001 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 50MG per ML
089519/001 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 50MG per ML
090368/001 FLUOROURACIL FLUOROURACIL CREAM/TOPICAL 5%
091299/001 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 2.5GM per 50ML (50MG per ML)
091299/002 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 5GM per 100ML (50MG per ML)
202668/001 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 500MG per 10ML (50MG per ML)
202668/002 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 1GM per 20ML (50MG per ML)
202669/001 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 2.5GM per 50ML (50MG per ML)
202669/002 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 5GM per 100ML (50MG per ML)
203122/001 FLUOROURACIL FLUOROURACIL CREAM/TOPICAL 0.5%
203608/001 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 500MG per 10ML (50MG per ML)
203608/002 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 1GM per 20ML (50MG per ML)
203609/001 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 2.5GM per 50ML (50MG per ML)
203609/002 FLUOROURACIL FLUOROURACIL INJECTABLE/INJECTION 5GM per 100ML (50MG per ML)

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