Application Information

This drug has been submitted to the FDA under the reference 003444/001.

Names and composition

"DRISDOL" is the commercial name of a drug composed of ERGOCALCIFEROL.


ApplId/ProductId Drug name Active ingredient Form Strenght

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ApplId/ProductId Drug name Active ingredient Form Strenght

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Answered questions

I am taking drisdol 50000 iu ca.?
how long will it take to have enough Vit D in my system? I am elderly Asked by Kelly Janiak 2 years ago.

Maximal effects of Drisdol (ergocalciferol, or vitamin D2) are observed in about 4 weeks, and maximal effect can last for up to 6 months. Drisdol is most commonly prescribed not only for vitamin D deficiency, but also osteopenia, osteomalacia, hypoparathyroidism, and secondary hyperparathyroidism; usual dosage is 1 capsule by mouth once a week for 4 to 12 weeks, after which time your physician will probably decrease your dose to 200-1000 units a day with an OTC supplement. Answered by Robbie Giachino 2 years ago.

Drisdol 50 000 Units Answered by Shawanna Frankenfield 2 years ago.

It takes about 2 weeks for any medication to start working. Answered by Damian Scheppe 2 years ago.

What is the source of the gelatin and glycerin used in the drug Drisdol (Vitamin D)?
Is it from a plant or animal source? That's basically what I'm trying to find out. Asked by Missy Sellinger 2 years ago.

Gelatin comes from animal bones so if you are looking for vitamin D that is acceptable to vegetarians you need vitamin D3 make from lanolin which is obtained by washing sheeps wool. You can get that form of vitamin D from Answered by Lida Zambelli 2 years ago.

Can vitamin d deficiency cause nausea?
I've been tested for Celiac twice, once by a stool sample, and then again by blood. Both came back negative. I've also had an endoscopy, which everthing looked normal, along with the biopsies taken. I was treated for Colitis, but later discovered it was a fase reading on my CTscan. So everything... Asked by Lisa Anglade 2 years ago.

I have been dealing with nausea, chronic weight loss, joint pain and many other symptoms for over a year now, and until now nothing has pointed to why. But two weeks ago my doctor discovered my vitamin D levels were low, [how low i don't know, i wasn't told.] So she put me on Drisdol. 50,000 UI a week for 12 weeks. I was wondering if vitamin d deficiency could be the cause of my symptoms. If it is, how long will it be before my symptoms start improving? I've been on it for a week. Answered by Louis Ogami 2 years ago.

I've been tested for Celiac twice, once by a stool sample, and then again by blood. Both came back negative. I've also had an endoscopy, which everthing looked normal, along with the biopsies taken. I was treated for Colitis, but later discovered it was a fase reading on my CTscan. So everything mentioned so far has been ruled out. But thanks for the advice, i just may try going on a Gluten free diet and see if that helps. Answered by Leopoldo Hiester 2 years ago.

Aloha, Let me start off by saying i'm a mess haha I have various things wrong with me so I can only tell you of my experiences that may relate to you. I have have a severe vitamin d deficiency and have noticed that when I forget to take my tablets that I feel more nauseous than usual. That's just my observation though. I just thought that I should suggest that you try going gluten free for about 2 weeks and noticing if you see a difference. I had been tested for coeliacs disease many times over the years and had several endoscopies but they always came back negative for anything. I decided to do a detox for a few weeks and when I had my first lot of gluten after (which I had unknowingly so there was no chance that it was 'all in my head') I felt awful. i checked it out online and there are masses of cases of 'non coeliac gluten-sensitivity'. Its medically recognized as a 'thing' now and my Doctor agreed that I have 'non coeliac gluten-sensitivity. Since going gluten free my nausea has reduced massively and I also think it helps my body to absorb the vitamin D because their is no irritation being caused. I'm no Doctor, I just think it's nice to share ones findings if they've found something that helps Good Luck with getting rid of the nausea! Answered by Cami Parrett 2 years ago.

Vitamin D Nausea Answered by Min Parzych 2 years ago.

I agree with the nurse. Apart from lack of sun exposure,vitamin D deficiency can also be found in Celiacs, inflammatory bowel disorders,lymphoma, granuloma,amyloid, chronic pancreatitis,cystic fibrosis,obstruction of bile,cirrhosis of liver, hyperparathyroidism,kidney disease, autoimmune disorders,anythgin else that causes malabsorbtion or maldigestion,plus others. Some good sources of vitamin D are below but since your taking Drisdol care needs to be taken that you dont receive too much vitamin d as too much vit D can lead to toxicity.This is controversy surrounding this however. Medicinal cod liver oil Pink salmon Tuna Whole milk(maybe not good idea?some have troubles with milk) Oysters Mackerel Shiitake mushrooms Sardines Answered by Jacqueline Klimko 2 years ago.

Hi Hailey. Indiechick, the Celiac nurse, gave you some excellent information. I gave her answer a thumbs up. Clearly, all of your symptoms are not caused by Vit. D deficiency. You and your doctor need to look for the underlying condition that can cause all of your symptoms. Celiac Disease is high on that list. Sadly, because Celiac Disease is a nutritional disorder it is rarely diagnosed by medical doctors (they still have almost NO TRAINING in nutrition!). Yet, Celiac Disease is very common - affecting about 1 in 100 Americans. There are many other potential disorders (other than Celiac Disease) than can be the cause of all of your symptoms. A competent doctor will do the hard work of working with you to figure it out. But proper testing for Celiac Disease is probably the best starting point. Best wishes and good luck. Answered by Sheilah Garnier 2 years ago.

I'll tell ya my take on it - I'm guessing they aren't really sure of the full scale of problems caused by vitamin D deficiency are at the time being... Those things don't sound as if they would be - but really the only way you'll have an inkling, is to take the medication and wait to find out if they resolve themselves. I had some odd symptoms improve when I started taking D (my doctor prescribed a much smaller daily dose)....I think you'll just have to wait and see... Answered by George Lesuer 2 years ago.

Difference between Vitamin D2 and D3?
I've noticed several different vitamin D supplements. You've got D2 and D3. So I wanted to know which one is better? AND.......... do they have the same final outcome? Thanks! Asked by Kraig Kaluna 2 years ago.

Hi Aaron J The Vitamin D Council is my primary source of Vitamin D information. Here's what they say in regard to your question: Non-prescription vitamin D supplements are available in the United States as either Vitamin D2 Ergocalciferol or Vitamin D3 Cholecalciferol. Both are referred to as "vitamin D" although they are different in their origins, metabolism, and potential toxicity. D3 or Cholecalciferol is the naturally occurring form of vitamin D. It is the substance made in large quantities in your skin when sunlight strikes your bare skin. D2, Ergocalciferol, is available to U.S. doctors in prescription strength and is sometimes used in multivitamin preparations—usually at 400 IU per pill. Your doctor can write a prescription for 50,000 units of ergocalciferol (brand names Drisdol and Calciferol). Ergocalciferol does not exist in detectable quantities in the human body, only in tiny quantities in plants and as such is "unnatural", when in the human body. You can not get any appreciable ergocalciferol by eating vegetables. Ergocalciferol is metabolized to various substances in the body, some of which are not normally present in humans, although these metabolites have never been shown to be dangerous. There is also some evidence that ergocalciferol is more toxic in overdose, which is curious as it is only about half as potent as the naturally occurring vitamin D, cholecalciferol. Dr. Mercola, a proponent of vitamin D testing, strongly suggests getting most of your vitamin D from sunshine and during the rest of the year, or if you are dark-skinned (because dark-skinned people need many times more sun exposure), getting it from D3 supplements. Mercola suggests the optimal level should be 45-50 ng/ml or 115-128 nmol/l. The Canadian Cancer Society recently announced its recommendation that its population take a D3 supplement of 1000 IU daily for cancer prevention. Vitamin D researchers often suggest higher daily intake. Answered by Bradley Mehlhaff 2 years ago.

Hello, There are studies that show that Vitamin D3 is the more effective of the two. Below is a reference article regarding some of the research. I take a very high quality multi-vitamin by Pure Encapsulations called "multi t/d" and they chose to use D3. Here is the research info: Breaking News on Supplements & Nutrition - North America Previous page : Vitamin D3 more potent than D2, further evidence Print Vitamin D3 more potent than D2, further evidence 6/21/2004- Vitamin D3 has significantly greater potency than another form of the vitamin, D2, shows a small study, presented last week. The researchers say D3 supplements will be much more effective at preventing deficiency of the vitamin, a condition gaining increasing attention from the medical community. Researchers writing in The Lancet last year warned that pregnant women and children should take vitamin D supplements to prevent a resurgence of rickets, the failure to mineralise new bone tissue leading to poorly formed bones. Its incidence is thought to be increasing due to several current lifestyle factors, including greater use of sun protection creams. Sunlight is the best source of vitamin D but for those exposed to little sunlight, supplements are recommended. Even vitamin D-fortified foods, such as cereals or yellow spreads, do not offer the recommended daily allowance, according to recent surveys. Since the 1930s, researchers have believed that vitamin D2 and D3 haveessentially the same benefits in people. However, recent studies have suggested that vitamins D2 and D3 are not the same and D3 tends to be more widely used. New findings, presented by Dr Laura Armas from Creighton University in Omaha and colleagues at ENDO 2004 in New Orleans, US, last week, appear to confirm this difference. The researchers examined the potency of both forms by randomly giving a single 50,000 IU dose of either vitamin D2 or D3 to 20 healthy male volunteers. Over a period of 28 days, blood levels of vitamin D and its product 25-hydroxyvitamin D were measured. The two calciferols produced similar rises in serum concentration of the native vitamin, indicating equivalent absorption. But while both produced similar initial rises in serum 25 hydroxyvitamin D over the first three days, serum 25OHD fell rapidly in the D2 treated subjects and was not different from baseline at 14 days. Meanwhile 25OHD continued to rise in the D3 treated subjects, peaking by 14 days and continuing to remain high. Calculating the difference in potency by measuring the area under the curve revealed an even greater difference with D3 more than nine times more effective than D2. The fall in 25OHD2 may reflect differences in the affinity of the vitamin D binding protein for the two calciferols, said the researchers. "Clearly vitamin D3 is the preferable form of vitamin D," they concluded, adding that "physicians using vitamin D2 should be aware of its markedly reduced potency and shorter duration of action". The D3 form does however pose some limitations. Some manufacturers are reluctant to use it as lanolin is used in its manufacture and this presents issues for vegans. Copyright - Unless otherwise stated all contents of this web site are © 2000/2007 – Decision News Media SAS – All Rights Reserved. For permission to reproduce any contents of this web site, please email our Syndication department: contact our Syndication department. Full details for the use of materials on this site can be found in the Terms & Conditions. Answered by Bao Ferkovich 2 years ago.

Does K2 help in the assimilation of D3 in Seniors or those with autoimmune diseases? Answered by Wilma Sydnes 2 years ago.

Why do you need a certain amount of thiamine and riboflavin in your diet every day, but not vitamin A & D?
Asked by Antone Steinbrenner 2 years ago.

Thiamine (B1), riboflavin (B2), the rest of the B vitamins and vitamin C are not stored in the body. They need to be 'replenished' every day. Vitamin A (retinol), vitamin D (calcitriol) along with vitamin E (ergocalciferol) and vitamin K (phytonadione) are 'fat soluble' vitamins and can be stored, to some degree, in the body. While these vitamins need to be replaced, the body can draw from these stores within the body. EDIT: Doc J is correct, I humbly stand, partially corrected. Busy day, sorry. Vitamin E is d-alpha-tocopherol. From a Pharmaceutical standpoint, phytonadione (Mephyton) is the tablet form of vitamin K and Aqua-Mephyton is the injectable form. Rocaltrol (calcitriol) and Drisdol (ergocalciferol) are the oral forms of vitamin D. Aquasol E is the oral form of vitamin E. Aquasol A is the oral form of vitamin A. Answered by Prince Marguardt 2 years ago.

Hi Claudia. ... because thiamine and riboflavin are NOT STORED in any significant amounts in the body. A and D, on the other hand, are stored in the body - thus a DAILY supply is not an absolute requirement. Best wishes and good luck. p.s. I feel I must correct some of the absolutely incorrect information provided by the 'pharmacist'. First, Calcitriol is 1,25 dihydroxyvitamin D - the active, hormonal form that is made from Vitamin D (cholecalciferol). Second, ergocalciferol is NOT vitamin E, it is the plant-based form of vitamin D. Next, vitamin E consists of four different forms of Tocopherols and 4 forms of Tocotrienols (it is NOT ergocalciferol, as noted above). Finally, Vitamin K is either phylloquinone, which is derived from green plants, or menaquinones, which are synthesized by bacteria. There is also menadione - a man-made, synthetic form of vitamin K. Oh, one more point. Vitamin A exists in three different chemical forms in the body: retinol, retinal, and retinoic acid. Answered by Ricky Dupuis 2 years ago.

One cannot generalize, for example B12 is a B vitamin and water soluble but stored for months in the liver. Vitamin K is produced by bacteria in the gut so is less essential in the diet. Other than that, the reasons given above are correct. Answered by Sydney Olshan 2 years ago.

You are sadly mistaken--an insufficiency of either one, and certainly of both, is a virtual guarantee of bad health. A can be abused by doses that are too massive. D3 is not retained by the body, is flushed out all the time, and must be taken daily in substantial doses if you get little sun or have certain skin criteria. Please Google Vitamin A and Vitamin D3 and get some information before you assume anything or ask any more questions. Answered by Fleta Leeds 2 years ago.


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