Application Information

This drug has been submitted to the FDA under the reference 019627/001.

Names and composition

"DIPRIVAN" is the commercial name of a drug composed of PROPOFOL.

Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
019627/001 DIPRIVAN PROPOFOL INJECTABLE/INJECTION 10MG per ML
019627/002 DIPRIVAN PROPOFOL INJECTABLE/INJECTION 10MG per ML

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
019627/001 DIPRIVAN PROPOFOL INJECTABLE/INJECTION 10MG per ML
019627/002 DIPRIVAN PROPOFOL INJECTABLE/INJECTION 10MG per ML
074719/001 PROPOFOL PROPOFOL INJECTABLE/ INJECTION 10MG per ML
074816/001 PROPOFOL PROPOFOL INJECTABLE/ INJECTION 10MG per ML
074848/001 PROPOFOL PROPOFOL INJECTABLE/INJECTION 10MG per ML
075040/001 PROPOFOL PROPOFOL INJECTABLE/ INJECTION 10MG per ML
075102/001 PROPOFOL PROPOFOL INJECTABLE/INJECTION 10MG per ML
075392/001 PROPOFOL PROPOFOL INJECTABLE/INJECTION 10MG per ML
077908/001 PROPOFOL PROPOFOL INJECTABLE/INJECTION 10MG per ML
205307/001 PROPOFOL PROPOFOL INJECTABLE/INJECTION 10MG per ML

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Answered questions

How come MJ died from taking Diprivan?
Isn't this the stuff docs used for anesthesia, so is this drug dangerous for surgery patients too Asked by Nancee Vlcek 1 year ago.

As an RN that works in intensive care, I do not understand why MJ would have even needed Diprivan (Propofol). It is a pure anesthetic, it doesn't kill pain (so it's not really addictive), and it only lasts but a few minutes once a continuous infusion is stopped, and people wake up almost instantly after it's turned off. Unless he literally couldn't sleep, even with things like ambien or lunesta, that's very odd. You don't really sleep on diprivan, you literally go into a coma, and can possibly lose your airway and stop breathing altogether (for instance by having your tongue block your airway). Which may explain how he died, but that would be a very odd situation. In ICU we use diprivan to keep really sick patients from moving around in bed when they are intubated and on a ventilator for respiratory support. It's the same in anesthesia, they want to make sure their patient stays in a coma while they're performing surgery and on a ventilator. Just a very odd situation. Answered by Freda Harklerode 1 year ago.

They haven't confirmed that he died from taking Diprivan. They found the drug at his home but they are still waiting for toxicology results from the autopsy so they can't be sure that he actually took it before he died. Answered by Valerie Slagter 1 year ago.

We don't know that he did. With that said, Propofol is a very safe drug when used by qualified people with adequate monitoring. This is not a drug that is ever used to induce sleep, but is used to induce unconsciousness. Why anyone would think this is a sleep aid I will never know. Unfortunately, some people think sleep and unconsciousness are synonymous. Answered by Eli Bob 1 year ago.

he got some pretty powerful adrenaline shots, he went from doctor to doctor asking for different meds, and the doctors never knew or found out, so the shot of adrenaline mixed with heavy drugs probably did him in Answered by Svetlana Garafalo 1 year ago.


Question about diprivan?
The doctor said he would not check his ammonia levels yet. I guess it would be hard on his body at this time? I am so worried. What can I have the dr. do to check? Asked by Elisa Yother 1 year ago.

My husband was intubated for a little over 2 weeks in icu. He is off diprivan now but after 2 days seems to not beable to talk or move. He can move his eyes and try to talk and move his eyebrows but that is it. Is he brain damaged or could the diprivan still be matabalizing out of his system? He has cirrosis of the liver and Could that be why it might not be out of his system yet? Please only answer if you really know or think you know not for the heck of answering please. Answered by Mable Gastello 1 year ago.

I am a critical care RN and have used a lot of Diprivan. usually the half-life of that drug is quite short. With the cirrhosis you might see an extension of the time it takes to "wear off" Diprivan doesn't have a paralyzing effect, but does have an amnesic effect. which is a good thing so he doesnt remember the intubation. I have used Diprivan since it came on the market and haven't seen paralysis from it. Being intubated and sedated for 2 weeks in and of itself can make you lethargic and with the additional cirrhosis, sedation, etc it might be awhile before he comes around. Is his Ammonia level high?? Answered by Collette Yzaquirre 1 year ago.

first of all i am sorry and know you must be going through a tuff time...ive been an icu and or nurse for 5 years and this is a tuff question with the limited history given...why was he intubated? there are several possibilites... first like the other nurse said the liver compication could slow the processing of the drug...but after 2 days id say it should be gone. have you considered a possible stroke, renal failure or anoxic encephalapathy? has he had a ct scan? what does it show? with some people it just takes a while to wake back up... give it a few more days...in the mean time visit him often...talk to him...and be strong Answered by Kiyoko Legallo 1 year ago.


Can DIPRIVAN® have fatal side effects?
they are saying that michael jackson could have been taking DIPRIVAN® before he died and they are considering that it could have had fatal side effects. Is the drug known to have fatal consequences? Asked by Sherryl Relford 1 year ago.

Diprivan is only administered in hospitals and should not be used at home without medical personeels. That's why it shouldn't be used at home. Usually when this drug is used doctors put tubes to your nose to assist with oxygen, mj didn't have this and I'm sure that's what caused his death. Also, hthe nurse said mj complained that one side of his body was cold, and the other was hot so the nurse told him to go to the hospital immediately but, he didn't. 4 days later he went into cardiac arrest. Answered by Freeman Hoovler 1 year ago.


Is Diprivan the Chemical Equivalent of Physically Knocking Someone Out?
Thanks Mathieu, I Suppose In a Number of Ways it is The Same, In Some Ways Different. Asked by Shantay Cobham 1 year ago.

What exactly do you mean? Are you asking if it will work as quickly as being knocked out? Well it is very hard to compare the two events. Propofol (Diprivan) is used to very rapidly induce sedation with our without full anesthesia. It is very powerful and works very quickly, only one or two drugs such as Midazolam and Sodium Thiopental (aka Sodium Pentothal) that work as quickly (but Midazolam is a bit slower). And unlike Pentathol in particular the risk of overdose is much less. I just thought of an old 'ER' episode where a doctors gives Propofol to a young 20 something because he accidentally heard over a speaker phone that his girlfriend had died (and it was phrased very insensitively). So the doctor (in a highly improper way) gave Propofol and the kid was 'knocked out' very quickly and lost his immediate memories right before the drug was taken (very normal). As for it being the equivalent of being physically knocked out I would say that is very hard to say. But it could be. Once the drug is injected it will PUT you to sleep not ease a person to sleep. The only type of drug I have herd relating a the chemical equivalent to a physical thing are antipsychotics, especially Haldol and Thorzaine. They are often still called "chemical straight jackets." Answered by Frances Perot 1 year ago.

No. Being knocked out doesn't effect the other systems of your body as much as a drug like diprivan. Answered by Shon Weyand 1 year ago.

When you get knocked out, you don't need to be put on oxygen like with diprivan. Answered by Mica Startin 1 year ago.

No. It doesn't knock someone out. It, like most anesthesia pretty much paralyzes the central nervous system, thus putting the person into a coma like sleep. When the anesthesia is stopped, the person wakes up. Answered by Natashia Mannella 1 year ago.


Do you need an analgesic for colonoscopy if diprivan is being given?
Asked by Jim Defosse 1 year ago.

I would say no. There is only mild discomfort after this type of procedure. Diprivan is used to maintain the anesthesia during the procedure. If you need something in addition to this which you probably won't just ask your doctor. They do not want you in pain! Answered by Roy Lohrenz 1 year ago.


What is the General Action and Specific Action of DIPRIVAN?
What is the General Action and Specific Action of DIPRIVAN? Asked by Carmelita Deuschle 1 year ago.

its propofol a type of sedative hypnotic used in anesthesia, this was also the drug michael jackson was using to hlep with his sleepless nites no one is exactly sure how it works in the body to cause all of its effects, but it does slow your heart rate and breathing, it is thought to inhibit the excitatory neurotransmitters in the brain, causing it to go to sleep Answered by Jaunita Arlotta 1 year ago.


How come MJ died from taking Diprivan?
Isn't this the stuff docs used for anesthesia, so is this drug dangerous for surgery patients too Asked by Evelia Pede 1 year ago.

As an RN that works in intensive care, I do not understand why MJ would have even needed Diprivan (Propofol). It is a pure anesthetic, it doesn't kill pain (so it's not really addictive), and it only lasts but a few minutes once a continuous infusion is stopped, and people wake up almost instantly after it's turned off. Unless he literally couldn't sleep, even with things like ambien or lunesta, that's very odd. You don't really sleep on diprivan, you literally go into a coma, and can possibly lose your airway and stop breathing altogether (for instance by having your tongue block your airway). Which may explain how he died, but that would be a very odd situation. In ICU we use diprivan to keep really sick patients from moving around in bed when they are intubated and on a ventilator for respiratory support. It's the same in anesthesia, they want to make sure their patient stays in a coma while they're performing surgery and on a ventilator. Just a very odd situation. Answered by Caleb Neymeyer 1 year ago.

They haven't confirmed that he died from taking Diprivan. They found the drug at his home but they are still waiting for toxicology results from the autopsy so they can't be sure that he actually took it before he died. Answered by Demetrius Chamble 1 year ago.

We don't know that he did. With that said, Propofol is a very safe drug when used by qualified people with adequate monitoring. This is not a drug that is ever used to induce sleep, but is used to induce unconsciousness. Why anyone would think this is a sleep aid I will never know. Unfortunately, some people think sleep and unconsciousness are synonymous. Answered by Darryl Mckeague 1 year ago.

he got some pretty powerful adrenaline shots, he went from doctor to doctor asking for different meds, and the doctors never knew or found out, so the shot of adrenaline mixed with heavy drugs probably did him in Answered by Camelia Roker 1 year ago.


Question about diprivan?
The doctor said he would not check his ammonia levels yet. I guess it would be hard on his body at this time? I am so worried. What can I have the dr. do to check? Asked by Lewis Collen 1 year ago.

My husband was intubated for a little over 2 weeks in icu. He is off diprivan now but after 2 days seems to not beable to talk or move. He can move his eyes and try to talk and move his eyebrows but that is it. Is he brain damaged or could the diprivan still be matabalizing out of his system? He has cirrosis of the liver and Could that be why it might not be out of his system yet? Please only answer if you really know or think you know not for the heck of answering please. Answered by Conrad Vanetta 1 year ago.

I am a critical care RN and have used a lot of Diprivan. usually the half-life of that drug is quite short. With the cirrhosis you might see an extension of the time it takes to "wear off" Diprivan doesn't have a paralyzing effect, but does have an amnesic effect. which is a good thing so he doesnt remember the intubation. I have used Diprivan since it came on the market and haven't seen paralysis from it. Being intubated and sedated for 2 weeks in and of itself can make you lethargic and with the additional cirrhosis, sedation, etc it might be awhile before he comes around. Is his Ammonia level high?? Answered by Christi Schaefers 1 year ago.

first of all i am sorry and know you must be going through a tuff time...ive been an icu and or nurse for 5 years and this is a tuff question with the limited history given...why was he intubated? there are several possibilites... first like the other nurse said the liver compication could slow the processing of the drug...but after 2 days id say it should be gone. have you considered a possible stroke, renal failure or anoxic encephalapathy? has he had a ct scan? what does it show? with some people it just takes a while to wake back up... give it a few more days...in the mean time visit him often...talk to him...and be strong Answered by Jamie Lubic 1 year ago.


Can DIPRIVAN® have fatal side effects?
they are saying that michael jackson could have been taking DIPRIVAN® before he died and they are considering that it could have had fatal side effects. Is the drug known to have fatal consequences? Asked by Ena Bakanauskas 1 year ago.

Diprivan is only administered in hospitals and should not be used at home without medical personeels. That's why it shouldn't be used at home. Usually when this drug is used doctors put tubes to your nose to assist with oxygen, mj didn't have this and I'm sure that's what caused his death. Also, hthe nurse said mj complained that one side of his body was cold, and the other was hot so the nurse told him to go to the hospital immediately but, he didn't. 4 days later he went into cardiac arrest. Answered by Serita Vacha 1 year ago.


Is Diprivan the Chemical Equivalent of Physically Knocking Someone Out?
Thanks Mathieu, I Suppose In a Number of Ways it is The Same, In Some Ways Different. Asked by Leslie Bouret 1 year ago.

What exactly do you mean? Are you asking if it will work as quickly as being knocked out? Well it is very hard to compare the two events. Propofol (Diprivan) is used to very rapidly induce sedation with our without full anesthesia. It is very powerful and works very quickly, only one or two drugs such as Midazolam and Sodium Thiopental (aka Sodium Pentothal) that work as quickly (but Midazolam is a bit slower). And unlike Pentathol in particular the risk of overdose is much less. I just thought of an old 'ER' episode where a doctors gives Propofol to a young 20 something because he accidentally heard over a speaker phone that his girlfriend had died (and it was phrased very insensitively). So the doctor (in a highly improper way) gave Propofol and the kid was 'knocked out' very quickly and lost his immediate memories right before the drug was taken (very normal). As for it being the equivalent of being physically knocked out I would say that is very hard to say. But it could be. Once the drug is injected it will PUT you to sleep not ease a person to sleep. The only type of drug I have herd relating a the chemical equivalent to a physical thing are antipsychotics, especially Haldol and Thorzaine. They are often still called "chemical straight jackets." Answered by Al Everhart 1 year ago.

No. Being knocked out doesn't effect the other systems of your body as much as a drug like diprivan. Answered by Darius Kuba 1 year ago.

When you get knocked out, you don't need to be put on oxygen like with diprivan. Answered by Cortney Mikota 1 year ago.

No. It doesn't knock someone out. It, like most anesthesia pretty much paralyzes the central nervous system, thus putting the person into a coma like sleep. When the anesthesia is stopped, the person wakes up. Answered by Inga Trundle 1 year ago.


Do you need an analgesic for colonoscopy if diprivan is being given?
Asked by Mariette Schlinker 1 year ago.

I would say no. There is only mild discomfort after this type of procedure. Diprivan is used to maintain the anesthesia during the procedure. If you need something in addition to this which you probably won't just ask your doctor. They do not want you in pain! Answered by Ronnie Metters 1 year ago.


What is the General Action and Specific Action of DIPRIVAN?
What is the General Action and Specific Action of DIPRIVAN? Asked by Valentin Sewester 1 year ago.

its propofol a type of sedative hypnotic used in anesthesia, this was also the drug michael jackson was using to hlep with his sleepless nites no one is exactly sure how it works in the body to cause all of its effects, but it does slow your heart rate and breathing, it is thought to inhibit the excitatory neurotransmitters in the brain, causing it to go to sleep Answered by Divina Siok 1 year ago.


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