DIFFERIN Ressources

Application Information

This drug has been submitted to the FDA under the reference 020338/001.

Names and composition

"DIFFERIN" is the commercial name of a drug composed of ADAPALENE.

Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
020338/001 DIFFERIN ADAPALENE SOLUTION/TOPICAL 0.1% **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
020380/002 DIFFERIN ADAPALENE GEL/TOPICAL 0.1%
020748/001 DIFFERIN ADAPALENE CREAM/TOPICAL 0.1%
021753/001 DIFFERIN ADAPALENE GEL/TOPICAL 0.3%
022502/001 DIFFERIN ADAPALENE LOTION/TOPICAL 0.1%

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
020338/001 DIFFERIN ADAPALENE SOLUTION/TOPICAL 0.1% **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
090824/001 ADAPALENE ADAPALENE CREAM/TOPICAL 0.1%
090962/001 ADAPALENE ADAPALENE GEL/TOPICAL 0.1%
020380/002 DIFFERIN ADAPALENE GEL/TOPICAL 0.1%
091314/001 ADAPALENE ADAPALENE GEL/TOPICAL 0.1%
020748/001 DIFFERIN ADAPALENE CREAM/TOPICAL 0.1%
200298/001 ADAPALENE ADAPALENE GEL/TOPICAL 0.3%
021753/001 DIFFERIN ADAPALENE GEL/TOPICAL 0.3%
201000/001 ADAPALENE ADAPALENE GEL/TOPICAL 0.3%
022502/001 DIFFERIN ADAPALENE LOTION/TOPICAL 0.1%
203981/001 ADAPALENE ADAPALENE SOLUTION/TOPICAL 0.1%
204593/001 ADAPALENE ADAPALENE SOLUTION/TOPICAL 0.1%
208322/001 ADAPALENE ADAPALENE GEL/TOPICAL 0.3%

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Answered questions

Has anyone used differin?
I'm going to start using it and I want to know how well it works. Also, how long does it take to start really clearing your skin, cause I want clearer skin by the time I get my braces off, which will be in late January. Asked by Erlene Estes 1 month ago.

I used Differin once but it didn't work for me. It took Accutane for me to get rid of my acne. But in any case, don't be disappointed. It is a very good drug. Apply a pea-sized amount on each side of your cheek, and another pea-sized amount on both your forehead and chin. Applying too much of it will dry out your skin a lot. All acne drug takes 6-8 weeks to show its full effect. This is because a pimple takes about 2-6 weeks to form. The zits you see on the surface of your skin now is actually formed weeks ago! On top of applying Differin, your regime should encompass proper cleansing as well. I've answered similar questions. This is one answer which I have said and I think it will help you. ...Wash your face two times a day - once in the morning and the other time before you go to bed. Don't overwash. I think you have a mild acne case so it isn't so bad. After washing up, apply your Differin. For your facial wash, try to get something that has salicylic acid or BP in it. The former will slough off dead skin cells on the surface of your face that will clog pores. I'll take a stab in the dark and say that you are a teen, and hormones are raging. It sucks, I know. Most importantly, don't pick OR EVEN TOUCH your pimples. Apply sunscreen with SPF 30 (at least) so that your acne won't flare up after being under the sun for some time (it saves you from skin cancer too). Drink enough water. And wipe away your sweat when you are perspiring heavily. With the right attitude towards acne treatment and prevention, you will have beautiful skin in no time. Exude confidence in yourself! Good luck! Answered by Leland Brazington 1 month ago.

There is no way of knowing how it will effect you or how long it could take because everyone's skin is different. I tried it and did not like it as it made my breakouts much worse. When you read the info that comes with the medicine it does say things can get worse before they get better but for me it just was not worth it as my skin was not terrible before but started to get terrible when taking Differin. It might work for you but if things do get worse and it bothers you enough I would advice you to stop taking it or talk to your doctor to see what his/her opinion is before you keep using it. Good Luck. Answered by Rolande Hertweck 1 month ago.

Have you attempted Proactive? And I realize this may occasionally sound humorous however I have a publication known as "Beauty Secrets from the Bible" and a pleasant option to cleanse and refresh your dermis is to scrub your face (or inflamed field) with salt. Be certain to rub in tiny circles everywhere, kk. And you probably have scars (from zits or anything else) or occur to get a wound or scratch...a pleasant option to avoid scaring and make certain quick cure is to use one hundred% bees honey (from a bottle from any grocery retailer) to that field. I wish this is helping honey Have A Happy =) Answered by Luba Mays 1 month ago.

I used it and it did not work for me. It is different for everyone so it may work for you. The only thing that worked for my acne was accutane. If you get discouraged don't stop using it it may help eventually. Answered by Iluminada Been 1 month ago.

For myself, it didn't work as well as Retin-A (Tretinoin) combined with Minocycline. Answered by Verlene Eure 1 month ago.


Differin!?!?
Okay, so my doctor prescribed Differin for my to use.But I don't use it for acne, I have red skin on my face, and little bumps on it too.So i know that when you use Differin, you break out kinda badly and then it gets better, right?Well, is that just when your using it for acne, or just when you use it... Asked by Renee Chamul 1 month ago.

Okay, so my doctor prescribed Differin for my to use. But I don't use it for acne, I have red skin on my face, and little bumps on it too. So i know that when you use Differin, you break out kinda badly and then it gets better, right? Well, is that just when your using it for acne, or just when you use it in general? PLEASE HELP. because red bumpy skin is better than having a pizza face. Answered by Kanesha Gabino 1 month ago.

I use Differin. I have used it for about two or three years for acne. Yes, it gets worse before it gets better. It takes probably about a week or two to get better if you use it every day! It should be the same for you, but I am not for sure. I am surprised that was prescribed for you because of your red skin. Differin makes your face dry, red, and sensitive. It should cure the bumps but I do not know about the red skin. I use this once every day for acne and it has really helped. Just make sure you keep up with lotion also, or you will have really bad dry skin. Make sure you do NOT put the Differin at the top and bottom corners of your mouth and under your eyes. It really dries them out and makes the skin extremely red. It takes days to go away. Also, do not let this get on your clothes, it bleaches them! Good luck! Answered by Alethia Bue 1 month ago.

I have used Differin and did not have a good experience with it, my skin got much worse. Not all medications will work the same for everyone and there is no way of knowing how it will effect your skin until you try it. My advice to you is that if you do try it and you start to see things you don't like, see your doctor again RIGHT AWAY to get his opinion or stop using it. Doctors can only advice you based on what they know but you have to make the final decision on how things are working for you and don't hesitate to stop if it is making things worse (but then again it might work for you like I said I just had a bad experience) Answered by Reggie Guadagno 1 month ago.


Am i using differin right?
Ok i use differin only at night i first wash my face with Neutrogena Oil-Free Acne Wash Foamy Cleanser then after i pad my face down lightly with a towl and then i put differin on and go to bed then when i wake up i wash my face with Oil-Free Acne Wash redness soothing gentle scrub by Neutrogena but i dont use... Asked by Antoine Lango 1 month ago.

Ok i use differin only at night i first wash my face with Neutrogena Oil-Free Acne Wash Foamy Cleanser then after i pad my face down lightly with a towl and then i put differin on and go to bed then when i wake up i wash my face with Oil-Free Acne Wash redness soothing gentle scrub by Neutrogena but i dont use differin after so am i using this right????? and please tell me so i could understand lol im only 14 i dont really know that much about this Answered by Oliva Preli 1 month ago.

differin is a topical retinoid. you should not be using any other acne-fighting medications other than the differin because it will irritate your skin and could cause the differin to not be able to do its job. so, it sounds like you need to stop using the neutrogena washes you currently use and find a gentle cleanser. some good ones are cetaphil, purpose, and basis. you could still use neutrogena, just stay away from scrubs and acne washes. whatever you choose, read the label to make sure it doesn't have any active ingredients, including saliclylic acid and benzoyl peroxide. after you wash your face, you should wait about ten minutes before applying the differin so that your face is fully dried. if you wish to moisturize after you apply it, use a non-medicated facial moisturizer about ten more minutes after the differin is applied. it should be fine that you're applying differin once per day in the evening, unless your doctor specifically told you to use it twice a day. i hope the differin works out for you. Answered by Eloisa Lawerance 1 month ago.

I actually use it in the MORNING after I shower. and i do NOT put on lotion over it, even though my dermatologist said that was ok. I apply for 2 wks straight, every morning. then take a wk break or maybe even two. Good Luck!! best topical I've ever used if you do it right ;) Answered by Leonel Breeman 1 month ago.


Dry skin and differin?
so my acne is between mild and moderate but its only on my cheeks. never any pustules just white heads. i talked to my doctor and he recommended differin gel, i only use it at night. and in the morning i use clindamycin 1% gel. im also taking tetracycline pills but i still have pimples, but the bad part is now im... Asked by Wanda Shani 1 month ago.

so my acne is between mild and moderate but its only on my cheeks. never any pustules just white heads. i talked to my doctor and he recommended differin gel, i only use it at night. and in the morning i use clindamycin 1% gel. im also taking tetracycline pills but i still have pimples, but the bad part is now im flaking rly bad. it also made my skin very sensitive. its so sensitive even when i chew i can feel my skin being streched when ever i open my mouth. i have been doing this routine for a week now and i heard its supposed to get worst before it gets better, is this true? also i need some advice on what face moisturizers i can use that wont clog pore and will get rid of all the flakes on my face. plz help Answered by Dania Ketterer 1 month ago.

I use Epiduo, which makes differin and has one of the same ingredients that Differin does + Benzoyl Peroxide so it's even more drying. Anyway, yes your acne will get worse before it gets better, which is what the ingredient if differing Is doing, it's a retinol which sheds dead skin cells faster so they don't get clogged in your pores. You should start seeing improvement in 6 weeks, could take longer, could not be that long. It just depends. My skin purged but I'm not for sure how long but I know it wasn't too long because at my 3 month check up with my derm she was so surprised at how well my skin looked! My skin also got really really dry. It sucks. But you just have to find a really good moisturizer. I used a bunch of different ones to find out what worked for me. Cetaphil is awesome for basic moisturizers that don't clog pores, but it not might be moisturizing enough for you. I would go would Neutrogena or Aveeno. Aveeno has really good sensitive skin formulas which sounds like is what you need. You will probably even need to moisturize day and night. I would do Aveeno during the day and something a little heavier for night. Just Trey looking at thiose brands websites to find something for your specific needs. Neutrogena is good if you have oily, normal or dry because they target those needs of those skin types. I'm not sure but Aveeno might have something for dry skin, but be careful it might clog pores. Look for non-comendogenic on the label. Also, what face wash are you using? If you're not prescribed one, make sure you're using a gentle one, non drying without any kind of acne medication. Infield go with Cetaphil again, or Olay might have a good moisturizing face wash. Drink plenty of water and keep slathering on moisturizer whenever you can. Now that my skin isn't dry from using Epiduo I'm using Mario Badescu products. They have great moisturizers and if you are willing to wait and order one online then they would probably have an excellent moisturizer for you. Actually I'm pretty sure they have one for over treated acne skin which would be perfect. I know it's hard, I went through it but it's so worth it. Just be VERY careful with your skin and don't apply anything else that's not necessary. Trust me when I say these things. Ive been there! Best of luck! Answered by Del Rodwell 1 month ago.

Differin Dry Skin Answered by Garnet Domin 1 month ago.

I would recommend Acne ace! I used it, and after 1 months, my acne was COMPLETELY gone! Hope it works for you. you can get From Google Search Acne ace Official site. Good luck. Answered by Erin Eck 1 month ago.

Yes, the cream is way better! use it, the gel sucked for me too. Answered by Ollie Ashlock 1 month ago.


Differin gel for acne, side effects?
what are some of the side effects for differin gel for acne, could depression be a side effect? Asked by Lorie Heyward 1 month ago.

Differin Side Effects | Drugs.com Home → Drugs by Condition → A → Acne → Differin → Side Effects. ... Some side effects of Differin may not be reported. ... Differin cream MedFacts Consumer ... www.drugs.com/sfx/differin-side-effect... - Cached Side Effects of Differin Gel .1% (Adapalene Gel) Drug Center ... Differin (adapalene) Gel, 0.1% is used to treat acne. It is a retinoid. This medication is available in generic form. Common side effects include a brief sensation of ... www.rxlist.com/differin-gel-1-side-eff... - Cached Differin - (Adapalene) Side Effects, Dosage, Uses ... Applying excessive amounts or using the gel or cream more ... What are the possible side effects of Differin? Side effects ... Side effects may include: acne ... www.pdrhealth.com/drugs/differin - Cached Answered by Evelina Machel 1 month ago.

It is a established, holistic acne remedy created more than years of research Answered by Perla Skibo 1 month ago.


Does Differin Start Working?
so, ive been on differin gel for about 5 days and so far all its done is given me dry, itchy red skin and two HUGEE cystic pimples (ive never gotten those before) ive read just about every review out there but im scared and want to know forsure if its worth it or if i should switch back to Duac. thanks :) Asked by Jule Noye 1 month ago.

DIfferin is really good, stick with it. I have been on it since last November, and I was just like you. Seriously I think I read probably every frickin review on it! I was really nervous especially when I got really bad pimples, even worse then I had before Differin. The thing is, it works differently on everyone. My acne got worse for about 5-6 weeks, and then all of a sudden one morning I woke up and I could tell the redness on my forehead was fading. Then a week later when I crinkled my eyebrows it didn't hurt from so many pimples! Anyways sorry I I'm writing so much but I just wanted to calm your nerves. It will take time but trust me, it's worth it. Don't stop now, you'll probably be looking clear by the time school starts. Also buy Cetaphil moisturizing lotion for all skin types and put it on at night after the Differin you put on dries. That should help a lot with the dry itchy skin. Sorry I wrote so much and good luck you'll be fine! Answered by Aaron Karakas 1 month ago.


What happens if i stop using differin after ive been using it for 4 months???
will i keep on getting worse acne or what i need help...!! pleaz Asked by Latina Lawer 1 month ago.

Differin didn't work for me but made me break out. I'm on Klaron an antibiotic lotion that goes on my face and Amoxicillin the pill 500MG. It's been working really well. I don't break out bad anymore. I tried accutane, I don't recommend it. It has nasty side effects and gave me hypotoxicity. I had severe pain in my abdomen, it was awful. I thought I was gonna die. I never felt something soooo awful. Don't try it unless you are desperate, it doesn't guaranty anything. And I followed all the rules. Plus then you have to go for blood tests, which are a pain. If you think differin works, continue using it. If it doesn't stop. Try to ask your doctor if you can use what I'm doing. I've been using it for about year already and it has made a huge difference and its not harmful to my body. Personally, I think I would stop using differin. For example, accutane caused me to get potholes in my face. Differin might do that to you. I'd stop, but consult your doctor. Answered by Daria Suryanarayana 1 month ago.

Your skin will go back to the way it was. Try to cut down your usage, if you can, but not stop altogether. After a couple months, it will be like you never used it. Answered by Dede Dekeyzer 1 month ago.


Differin...?
I used differin for about 2 months and it made my face break out like never before i quit it about a month ago and it's better but I still have whitehads and blackheads on my T-Zone it's not even close to being as clear as before I started Differin. Does anyohne know how long it takes to get it out of your... Asked by Laverna Strehl 1 month ago.

I used differin for about 2 months and it made my face break out like never before i quit it about a month ago and it's better but I still have whitehads and blackheads on my T-Zone it's not even close to being as clear as before I started Differin. Does anyohne know how long it takes to get it out of your system and what prescribed medications actually work with side effects that won't make you break out more? I'd really appreciate answers thanks Answered by Willy Drisko 1 month ago.

If you go to Medicinenet.com and look up Differin, it will tell you that is part of the medicine working by bringing up pimples or blockages unseen , and to expect it for up to 8-12 weeks. Unless you had peeling major or were out in the sun it was supposedly doing its job. Topicals are better,unless you want to go on a low dose birth control. Azelex used to be another that was prescribed along with differin to move the process along. Speak to your doctor again. Natural ways to help skin-drink water, don't overdue the sun, whatever touches your face make sure it is clean, keep your fingers away, change your pillow case often. If you enjoy carrot juice, drink up, it's like retin-a for the inside of your body,when I juice my skin glows. I am sensitive skinned which could be your issue too, which means the drug store stuff only works for a bit and then it does more damage because my skin becomes irritated. Best wishes- Answered by Rebecca Dellacioppa 1 month ago.

ask your dermotologist. stop using it. and try avon acne exfoliating scrubs and true-porefection from avon. it will stop the acne!!! i have been using this system for about a week now together and it works amazing! my skin was breaking out bad yesterday and i used it and over-night my skin is practically flawless!!!!!! Answered by Nilda Lieber 1 month ago.

you should go to the dermatologist and get some laser thingy where they clean out your pores. i forgot the name of it but i saw it on extreme makeover Answered by Hilde Fansler 1 month ago.


Do I wash differin in the morning or leave it on?
i mean i put differin on before i got to bed and like im just saying when i wake up should i wash it off or no? Asked by Ken Fitzsimons 1 month ago.

I have been using Differin for over a year & I know that this answers more than the question you asked but I figured that if you are asking this then you may have other questions about the product. -Its extremely important that you wash your face in the morning and at night. It is best to use a gentle face cleanser with no medicine in it. (I use Noxema) -Also you should pair this regimen with a moisturizer with SPF. (I use Oil of Olay which is SPF 15 [I think]) -A.M.= wash face w/gentle cleanser. rinse completely. apply moisturiser. It is best to do this while your face is still damp. -P.M.= wash face w/gentle cleanser. rinse completely. apply Differin. wait approx 20 seconds for it to saok into skin. apply moisturiser. -In order for this medication to work properly you need to use it EVERYDAY. especially in the beginning. For me I broke out really bad the first 2 months I used it then my face stayed basically pimple free if I did the above A.M. & P.M. instructions. -You break out badly in the beginning of this treatment because Differin brings all the "brewing" acne in your skin to the surface basically all at once to get it out. -I have noticed that if I skip washing my face just once I will break out. Differin is highly effective though. -Recently I discovered a method of "pretreating" my face that usually helps. take a small amount of the face cleanser and put it directly on a DRY area where you can feel a zit coming or there already is a zit. Let it stay for approx. 2-5 mins (so while your waiting brush your teeth, put your contacts in, ect...). put the cleanser on the entire face then rinse as you normally would. This allows the cleanser to clean deeply directly in the problem area. Think of it the same way pretreat your laundry. -I also drink TONS of water & am on birth control which help. Answered by Sanjuana Mackins 1 month ago.

WHAT? No,NO, in spite of you do, wash your face two times an afternoon. Is your well-being care provider on something? think of roughly it, throughout the time of the hours of the day, you have oil, dirt, and bacteria boost. no longer washing all that off could reason pimples, blackheads, and whatnot. I used to apply Differin, yet I washed my face two times an afternoon. did no longer reason any problems. yet, on the different hand, Differin worked not greater acceptable for me than all the different pimples drugs. Answered by Roxana Ruszala 1 month ago.

you should wash it off because if you keep it on your at more risk for sunburn. Answered by Altagracia Gadson 1 month ago.


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