Application Information

This drug has been submitted to the FDA under the reference 012541/002.

Names and composition

"DEPO-PROVERA" is the commercial name of a drug composed of MEDROXYPROGESTERONE ACETATE.
It belongs to the class Depot contraceptives and is used in Depot contraceptives (Contraception)

Answered questions

Depo provera.. spotting?
okay so I've benn on depo for almost 3 years now and have never had a problem until a few weeks ago. i have been spotting for the past 3 weeks now and its been very weird. it ranges from brown spots to really bright red. i've looked online for info but every website says something different.the thing... Asked by Catherin Levenson 6 months ago.

okay so I've benn on depo for almost 3 years now and have never had a problem until a few weeks ago. i have been spotting for the past 3 weeks now and its been very weird. it ranges from brown spots to really bright red. i've looked online for info but every website says something different. the thing is, my boyfriend and i started having sex again so i thought this was a reason why i was spotting. ive also been working out and sometimes heavy work outs cause spotting. i havent had sex in two weeks or done any exercise to see if this had anything to do with the spotting... BUT i still have spotting. I havent had my period in almost 3 yrs so is this normal? the spotting has been happening for 3 weeks now.. if someone has some advice please let me know.. thanks! Answered by Laureen Cembura 6 months ago.

Depo Shot Spotting Answered by Chet Ernzen 6 months ago.

Spotting On Depo Answered by Derick Kopin 6 months ago.

I went on the depo around 13 years ago and bled for 6 months straight.. not heavy just spotting. After 6 months I finally built up the courage to go see a doctor... and was prescribed Ponstan... It cleared it up like a charm. I only had one shot and that was it. 13 years later... I decided to give it another go... I told my current doctor about the Ponstan and he prescribed that as well. Worked a treat. I was about 4 months overdue for my next shot (but wasnt sexually active in that time anyway) and recently had another shot. This time I have the brown spotting etc.. The Ponstan 250mg doesnt seem to be kicking in (should do so after a week) so tomorrow I'm heading to the docs again to request the stronger version which is what I used originally. Fingers crossed but it works for me. I asked recent doc why it works so well.. he explained that it's because Ponstan reduces haemoraging (spelling?) I was Answered by Darius Blevans 6 months ago.

depo is very tricky. Ive also been using it for a few years, and sometimes i never get spotting but then theres times that i spot for weeks and weeks. the spotting is normal, you have nothing to worry about. Birth control is like that sometimes, you are interfering with your body's normal function in taking birth control though. Answered by Demetrius Magathan 6 months ago.

I commend you for using depo... my first try at it and i bled for 3 months non stop... you should see your doctor asap Answered by Jan Chhum 6 months ago.

It is possible, but I'm not convinced Answered by Amado Hechmer 6 months ago.

About Depo provera?
sorry hopefuly you can read it my key bored is not working right and my cp is being realy slow Asked by Yee Rouleau 6 months ago.

What are the chances of getting pregnant with Depo Provera? It is unusual to get pregnant while taking Depo-Provera regularly, but pregnancies sometimes occur before the shot is given, and then go unrecognized until there is an obvious sign, like fetal movement. If a woman does becomes pregnant while using Depo Provera, and continues her pregnancy, there may be an increased risk of premature birth. Pregnancy and Depo Provera are like sunshine and rain. There is an extremely rare chance of them being together. Famed as one of the best birth control pills, Depo Provera is also infamous for preventing pregnancies even after use. This can be blamed on the long term effects of the hormone progestin, which is the main ingredient of Depo Provera. Depo Provera is a hormone injection that lasts for 3 months to prevent pregnancy. It is a long-acting progestin based contraceptive is given as a shot into your arm or buttock once every three months. The injection has synthetic progesterone and no estrogen. Depo Provera stops the ovaries from releasing eggs and thus prevents pregnancy by preventing the ovarian egg cells from maturing and releasing from the ovary. If an egg does not mature and release from either ovary there is no egg to be fertilized by sperm and pregnancy cannot occur. Depo Provera shot also changes the condition of the lining of the uterus so that pregnancy is less likely to occur. The effectiveness of Depo Provera in preventing pregnancy starts to wear off after three months, but the medication may remain in your body for up to a year. Due to the risk of serious health problems, Depo Provera is not recommended for women who are planning on becoming pregnant in the near future, are concerned over weight gain, have liver disease, gallbladder disease, or a history of depression. Your clinician or doctor can help you decide. There are also a lot of other associated disadvantages of Depo Provera that can hinder conception after long term use. The long term use of this medication causes irregularities in menstrual cycles for many women. Though medically they are acceptable as side effects, they can be very disturbing for some women. Irregular, heavy, or no bleeding are common side effects of Depo Provera. After a year of use, many women stop having periods. By the second year of use, many women have no periods at all. In addition, they can also be misleading for women who want to keep track of their menstrual cycles. Another concern for many women who are considering using or are using Depo-Provera is weight gain. On average, women gain about five pounds during the first year of use, so if you're using this method, it's a good idea to pay extra close attention to your eating habits and to get into an exercise routine. Furthermore, women who use Depo Provera may face an increased risk of osteoporosis and are advised to exercise and take in plenty of calcium. Some studies suggest, however, that bone density is restored once women stop taking Depo Provera. If you have been on Depo Provera and decide you want to get pregnant, it may take more than a year to regain your fertility. Don't forget to take either folate or a daily vitamin that contains folate while you are off Depo Provera and trying to get pregnant. Folic acid can prevent birth defects that occur in the period before you might even know that you're pregnant. Answered by Luci Girona 6 months ago.

the chances of you getting pregnant on depo is extremely low. however there is more to be worried about with depo. you lose 2.5 bone mass density every year you are on it. doesnt sound like much but it is and can lead to osteoporosis very early in life. take calcium supplements with vitamin d in it. also alot of owmen have trouble conceiving for years after getting off the shot. there are other hormonal problems with it such as severe weight gain, extreme hunger, facial and body hair that isnt supposed to be there and wont go away. big stroke risk, infertility. look this up further and i would advise to get on a different birth control. personally i gained 25 lbs in 6 months on depo!! and started to grow little hairs after i took it on my fc stomach and chest ewww!!!. never had this problem before! looked it up and its pretty common. the weight i gained was really hard to lose because it took forever for the hormones to leave my body after getting off it. Answered by Adelaida Beards 6 months ago.

yes i got pregnant right before i got the shot so it was too early to tell and even the clinic got a negative results but sure enough i miscarried and with the hormone still in my system doctor's confirmed that i had been pregnant. i bleed for 6 weeks. Answered by Dale Miah 6 months ago.

Has anyone had a good experience with Depo Provera?
I've noticed a lot of people are saying really bad things about it. The main ones that worry me are the weight gain and the hair loss. People have reported to have lost 20+ pounds. But I mean, is it ALL the shots fault or was it because your cravings for food increased? Does anyone have any good... Asked by Cameron Steindorf 6 months ago.

I've noticed a lot of people are saying really bad things about it. The main ones that worry me are the weight gain and the hair loss. People have reported to have lost 20+ pounds. But I mean, is it ALL the shots fault or was it because your cravings for food increased? Does anyone have any good experiences with this form of birth control? Answered by Adell Zinsli 6 months ago.

Depo-Provera has several advantages:[3][4][17][18] * Highly effective at preventing pregnancy. * Injected every 12 weeks. The only continuing action is to book subsequent follow-up injections every twelve weeks, and to monitor side effects to ensure that they do not require medical attention. * No estrogen. No increased risk of deep vein thrombosis (DVT), pulmonary embolism (PE), stroke, or myocardial infarction. * Culturally acceptable. Some cultures believe injections are especially efficacious. Injections also afford privacy because use is not detectable. * Minimal drug interactions (compared to other hormonal contraceptives). * Decreased risk of endometrial cancer. Depo-Provera reduces the risk of endometrial cancer by 80%. The reduced risk of endometrial cancer in Depo-Provera users is thought to be due to both the direct anti-proliferative effect of progestogen on the endometrium and the indirect reduction of estrogen levels by suppression of ovarian follicular development. * Decreased risk of iron deficiency anemia, pelvic inflammatory disease (PID), ectopic pregnancy, and uterine fibroids. * Decreased symptoms of endometriosis. * Decreased incidence of primary dysmenorrhea, ovulation pain, and functional ovarian cysts. * Decreased incidence of seizures in women with epilepsy. Additionally, unlike most other hormonal contraceptives, Depo-Provera's contraceptive effectiveness is not affected by enzyme-inducing antiepileptic drugs. * Decreased incidence and severity of sickle cell crises in women with sickle-cell disease. In the largest clinical trial of Depo-Provera, the most frequently reported adverse reactions (which may or may not be related to the use of Depo-Provera) were: menstrual irregularities (bleeding or amenorrhea or both), abdominal pain or discomfort, weight changes, headache, asthenia (weakness or fatigue), and nervousness. Other, less frequently reported adverse reactions are listed in the patient and physician label information for Depo-Provera. Answered by Cleora Deeley 6 months ago.

It was the first birth control I ever used. I only used it for 9 months because I bled continuosly for those 9 months. I didn't gain weight or anything else with it. The bleeding was the only side effect I had. Its very convenient and worth a shot to see how your body reacts to it. You might have no problems from it. Answered by Chae Julio 6 months ago.

About the Depo provera?
While antibiotics does the depo shot fail?I can't remember if the doctor told me yes or no..I have been on antibiotics for only 4 days, but I also have had unproteced sex.Can it fail and what are the chances I may be pregnant.i'm not having symptoms or anything, but they curiosity is killing... Asked by Maribel Nabozny 6 months ago.

While antibiotics does the depo shot fail? I can't remember if the doctor told me yes or no.. I have been on antibiotics for only 4 days, but I also have had unproteced sex. Can it fail and what are the chances I may be pregnant. i'm not having symptoms or anything, but they curiosity is killing me Just to be safe I. Answered by Kandis Tentler 6 months ago.

Antibiotics can interfere with any hormonal birth control, so you should always use a backup method when you're on antibiotics. Your chances of being pregnant are still pretty slim, but you should probably go ahead and take a test, just to be on the safe side. Answered by Lillie Arrellin 6 months ago.

i was told that antibiotics do not interfere with depo provera Answered by Florida Munnerlyn 6 months ago.

Is depo provera a good choice for birth control?
does it work good? Asked by Rossie Norcia 6 months ago.

Warnings and precautions Depo Provera can require up to fourteen days to take effect. This means pregnancy can occur within fourteen days of the first Depo injection. Takes seven days to take effect if given after the first four days of the period cycle. Effective immediately if given during the first four days of the period cycle. Offers no protection against Sexually transmitted diseases (STDs). Depo Provera can affect menstrual bleeding. After a year of use, 55% of women experience amenorrhoea; after 2 years, the rate rises to 68%. In the first months of use "irregular or unpredictable bleeding or spotting, or rarely, heavy or continuous bleeding" was reported. Delayed return of fertility. The average return to fertility is 9 to 10 months after the last injection. By 18 months after the last injection, fertility is the same as that in former users of other contraceptive methods Long-term studies of users of Depo-Provera have found slight or no increased overall risk of breast cancer. However, the study population did show a slightly increased risk of breast cancer in recent users (Depo use in the last four years) under age 35, similar to that seen with the use of combined oral contraceptive pills.[16] Infants born to women exposed to Depo during pregnancy in one study had an 80% greater chance of dying in the first year of life. [edit] Black box warning While it has long been known that Depo-Provera causes bone loss, it has recently been discovered that the osteoporotic effects of the injection grow worse the longer Depo-Provera is administered, may remain long after the injections are stopped, and may be irreversible. For this reason, on November 17, 2004 the United States Food and Drug Administration and Pfizer agreed to put a "black box warning" on Depo-Provera's label. However, the World Health Organization (WHO) advises that the use of Depo Provera should not be restricted. It is unclear whether the bone density loss associated with Depo-Provera use is reversible, and if so, how completely. Three studies have suggested that bone loss is reversible after the discontinuation of Depo-Provera, although one notes that bone loss was not reversible in long-term users of Depo-Provera. Other studies have suggested that the effect of Depo-Provera use on post-menopausal bone density is minimal,[24] perhaps because Depo users experience less bone loss at menopause. However, as of 2006, no study has directly examined fracture risk in post-menopausal women who have used Depo-Provera; therefore, the risk is unknown. Pfizer and the FDA recommend that Depo-Provera not be used for longer than 2 years, unless there is no viable alternative method of contraception, due to concerns over bone loss. Side effects Depo-Provera may have side effects, in order of greatest frequency:[26] menstrual irregularities (irregular bleeding, amenorrhoea absence of bleeding or metrorrhagia constant bleeding) nausea, vomiting, headaches, dizziness, breast swelling and tenderness, depression, skin disorders (rash, hot flushes, acne, alteration hair growth), alteration in appetite, altered weight and changes in libido. Other possible associated side effects are set out in the product licensing and patient labelling with some rare but potentially serious effects being: convulsions, jaundice, urinary tract infections, allergic reactions, fainting, paralysis, osteoporosis, lack of return to fertility, deep vein thrombosis and pulmonary embolus. FAilure Rates Most sources cite the failure rate for Depo-Provera at 0.3 percent annually, which would be three women out of a thousand per year. The two year combined failure rate for Depo-Provera, Norplant, and IUD use for women aged 20-24 was 10.9 percent, which comes out to one woman in ten. Answered by Sharleen Skovlund 6 months ago.

It can be great for some women that don't want to think about taking tablets everyday, and is normally given as an option to help women who suffer from endometriosis, (I have been operated for twice for endometriosis and was given the shot, I ended up getting my period for 6 months, and suffered alot of nausia, my mother who also has been operated for for endometriosis, also had the shot, she didn't suffer ongoing bleeding but suffered sever weight gain and nausia.. The shot doesn't actually make you gain weight, but it does increase your appetite alot so if you are not a person who controls their eating habits well you can gain alot of weight... I never had this problem as I am always very busy and exersize alot, and eat a balanced diet.. My mother on the other hand is not very good at controlling her appetite and when she felt hungry she ate, and ate not the right food, so she put on loads of weight... You have to weigh up what is right for you , I have met loads of women that swear by depo provera, and have met loads that think its the worst thing ever made, I personally wouldn't take it again, but I beleive it's important to try different things and find out what works for you, for me the Contraceptive ring is fabulous a ring which you change every month (not a diaphram) it looks like a thick rubber band all you do is place it up there, and it goes unnoticed its been fabulous, and because you dont take it like a tablet which goes though your stomache you dont get nausia.. Ask your doctor about it, in Spanish it is called Anillo Contraceptivo Best of luck Answered by Danica Shiyou 6 months ago.

Exercising each day when compared with morning Answered by Scott Siemers 6 months ago.

while eating dinner out test to have a healthier solution Answered by Torie Abeb 6 months ago.

It works well however, I was on it for three years and it made it that I gained 60 pounds and it took my husband and I 13 months to get pregnant after being on it. If you can remember the pill Yasmine was my favorite. Answered by Burma Cavalcante 6 months ago.

NO! No No No No No NO No No I don't know WHY that shot is still on the market. You can get all sorts of scary illnesses from it, including mental problems like anxiety and depression... My daughter tried this shot... please please don't make her mistake. It was AWEFUL for her. If you don't believe me, do some online research, there are women all over who had terrible side effects. Answered by Shawnda Ernstes 6 months ago.

Adhere to an increasingly trim protein/green vegetable eating habits Answered by Palmer Rimple 6 months ago.

It is highly effective against pregnancy, but it can make you gain weight like crazy! Answered by Alecia Gendusa 6 months ago.

Symptoms of Depo Provera?
Please help, I'm really concerned .. Asked by Ouida Deliberto 6 months ago.

I'm having pregnancy symptoms, nausea, sore and enlarged breasts, weight gain, appetite lose, vomiting, but it makes since because I have sex without protection.. I am also having major depression and suicide thoughts which isn't normal for me at all.. I am very worried. I got my first shot on October 11th, 2011 & need to get my next one on the 4th of January 2012. I want to try for a child though, I don't think I should get my next one. Please help me out, I know this shot isn't 100% effective and that there in a chance I may be pregnant. I do have annual pap smears and just had one last month. I missed my period also, I was suppose to get it around November 15th but I also know that that can be a side effect of the shot. I am a 15 year old girl, I have been on the pill and can't remember, I have been on the ring and can't stand it. I just need to know if these may be symptoms or not and how long it might take to conceive. Thank you very much!! :D Please do not give me a lecture if you do no like what I am doing, I don't care.. Answered by Jill Clankscales 6 months ago.

it would be simply from depo provera .. which i can under no circumstances take once more btw .... however simply to be definite .... take an at house experiment. if it is confident don't get an extra shot. it extremely not likely so that you can be pregnant however the ones do sound like being pregnant signs. Answered by Yolando Bostick 6 months ago.

Birth control like depo provera?
If i go on the birth control is it safe not to use condoms? Does it stop your chances of getting pregnant? My and my partner would like to be happy and as my body does not get along with condoms will it be okay not to use them if i go on birth control? We dont wanna have kids!! Asked by Terisa Siar 6 months ago.

Depo-Provera injection:Depo-Provera shots are injections of female hormones given in a woman’s arm or buttocks every 3 months. It works by preventing ovulation and interferes, with eggs leaving the ovaries, as well as changing the lining of uterus which prevents sperms from entering it. Depo-Provera begins to give protection against pregnancy within 24 hrs of the first injection, which must be given within five days of the beginning of a period, unless the women has been using the pill or an IUD. Depo-Provera protects you from pregnancy for 3 months until you get the next shot. Usually the shot area is not sore, though women have irregular periods while they are using Depo-Provera. Answered by Tonie Bembury 6 months ago.

No birth control is 100% effective, but I used depo provera for almost 3 years and never got pregnant. Me and my husband did not use condoms during that time. I would recommend it. Again, there's always a chance of getting pregnant using any BC method. P.S. Depo has a lower fail rate than condoms :) Answered by Wilda Sellards 6 months ago.

Has anyone had problems after the depo provera injection?
Hi there my last depo provera injection was in july 2003 im just wondering why i haven't had my periods again.What happened with anyone else that has had this injection.What were the side effects and long term effects Asked by Agustina Rothmann 6 months ago.

Depo-Provera Birth Control Injection (medroxyprogesterone acetate) is the U.S. brand name of a birth control product manufactured by Pfizer Inc. It is a hormonal birth control method containing the pregnane (17α-hydroxyprogesterone derivative) progestin medroxyprogesterone acetate, without estrogen, and is administered to women in the form of an intramuscular injection once every 11 to 13 weeks. Depo-Provera causes the ovaries to stop releasing eggs. Ladies using Depo-Provera has lot of worst side effects and it may be one of the reason you have not got the periods The genral side effect of this medicine are - For some women, Depo-Provera may have a number of potentially intolerable side effects, including loss of interest in sexual activity, infertility, severe headaches, constant bleeding (metrorrhagia), weight gain, panic attacks, muscle pain, heart palpitations, pain during sex, acne, irregular menstrual bleeding, absence of bleeding, abdominal cramps, dizziness, weakness or fatigue, leg cramps, nausea, vaginal discharge or irritation, breast swelling and tenderness, bloating, swelling of the hands or feet, backache, depression,insomnia, pelvic pain, no hair growth or excessive hair loss, rash, hot flashes,joint pain, convulsions, jaundice, urinary tract infections, allergic reactions, fainting, paralysis, deep vein thrombosis, and pulmonary embolus. I suggest you to consult your Gynocologist and have her advice and act accordingly. Do not take any medication etc., on your own or somone's saying. Answered by Sparkle Naborg 6 months ago.

I did not get my period for 6 months after the depo shot. However, if you have not gotten your period in more than 3 years you should be running to the GYN office!! Have blood test work done to see if you have a thyroid problem, premature ovarian failure, PCO or an even more serious condition. Anyone of these conditions that I mentioned can lead to more complications that you can imagine. I know, I have them all! Answered by Jovan Martensen 6 months ago.

I didn't get mu period back until about 6 months after I got off teh shot. The doctor told me if I didn't get it back within 6 months to go see her, she would firgure out what was wrong. So give it a few months. Answered by Mireya Pehowich 6 months ago.

the only problem i had was i put on 30lbs & didn't get my periods for a year , go to your doctor & ask him or her what do they think the problem is while your there ask your doctor to give you a full check up do it soon your health is the most important thing you have in this world look after yourself because no one else will best of luck Answered by Pamelia Mcguigan 6 months ago.

i blew up like a blimp. i gained 5 pounds a month.for a total of 45. the first time i was on it for birth control. i stayed on it for about a year. my periods immediately went away and when i stopped they immediately came back. the second time i was on it i gained 40 pounds, but this time my doc put me on it to stop my periods because they were so heavy. i whined and complained the whole time but because of my blood pressure it was my only option. each time my weight got to a peak and stopped adding on. Answered by Magen Ashlin 6 months ago.

I wouldn't have my period for months and then I gained weight with it. They saw once you get off of it to try to get pregnant that it may take 6 mths to a year to get out of you system. Iwas lucky, it took me 3 mths to get pregnant once I stopped it. Answered by Ezekiel Anglen 6 months ago.

Opinions from girls who are/have been on depo-provera injection very appreciated!!?
How long do the breakthrough spotting averagely last for?! Asked by Aileen Kennin 6 months ago.

two weeks ago i got my first depo injection.. everythings fine, then last week me and my boyfriend had sex without a condom for the first time.. two days later ive noticed ive been getting a brown discharge, which over the last three days has got darker and thicker..almost like what you get during the last few hours of your period as its coming to an end..if i was due to be on my period i wouldnt think twice but im not due for another 2 weeks. im just wondering if anyone else has experienced this? thanks girlies xxx Answered by Shelley Peyre 6 months ago.

its highly unlikely that your unprotected sex is related to your discharge. you should speak to your doctor if you're experiencing discharge, and ask how long spotting lasts for (on and off, in my experience, throughout the months you're taking depo). in response to the poster above - please reign in your biased internet-based understanding of a pharmaceutical drug, and don't buy in so easily to the money-making drive behind marketing the depo shot. i have been on this shot for over 8 years and am very much aware of the side effects. taken responsibly, and with careful watch over symptoms, this drug is ABSOLUTELY safe. it is also much more effective as a birth control method than other forms (i.e. pill). this shot will NOT kill you. at worse you will gain weight, have headaches, and experience bone density loss (after 2+ years of use). talk to you PHYSICIAN about drugs - do NOT take the advice of posters like this! Answered by Vivan Ozment 6 months ago.

i've been on the depo shot for months and i know for a fact that it's normal to have breakthrough spotting when it's not yet time for your period. your body will get used to it and it'll happen less often. Answered by Sara Mcconnico 6 months ago.


ApplId/ProductId Drug name Active ingredient Form Strenght
012541/002 DEPO-PROVERA MEDROXYPROGESTERONE ACETATE INJECTABLE/INJECTION 100MG per ML **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
012541/002 DEPO-PROVERA MEDROXYPROGESTERONE ACETATE INJECTABLE/INJECTION 100MG per ML **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**


Manufacturer name
Pfizer Ltd

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