Application Information

This drug has been submitted to the FDA under the reference 005010/001.

Names and composition

"DEMEROL" is the commercial name of a drug composed of MEPERIDINE HYDROCHLORIDE.

Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
005010/001 DEMEROL MEPERIDINE HYDROCHLORIDE TABLET/ORAL 50MG
005010/002 DEMEROL MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 50MG per ML
005010/003 DEMEROL MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 100MG per ML
005010/004 DEMEROL MEPERIDINE HYDROCHLORIDE TABLET/ORAL 100MG
005010/005 DEMEROL MEPERIDINE HYDROCHLORIDE SYRUP/ORAL 50MG per 5ML **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
005010/007 DEMEROL MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 25MG per ML
005010/009 DEMEROL MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 75MG per ML
021171/001 DEMEROL MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 25MG per ML
021171/002 DEMEROL MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 50MG per ML
021171/003 DEMEROL MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 75MG per ML
021171/004 DEMEROL MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 100MG per ML

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
005010/001 DEMEROL MEPERIDINE HYDROCHLORIDE TABLET/ORAL 50MG
005010/002 DEMEROL MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 50MG per ML
005010/003 DEMEROL MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 100MG per ML
005010/004 DEMEROL MEPERIDINE HYDROCHLORIDE TABLET/ORAL 100MG
005010/005 DEMEROL MEPERIDINE HYDROCHLORIDE SYRUP/ORAL 50MG per 5ML **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
005010/007 DEMEROL MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 25MG per ML
005010/009 DEMEROL MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 75MG per ML
021171/001 DEMEROL MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 25MG per ML
021171/002 DEMEROL MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 50MG per ML
021171/003 DEMEROL MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 75MG per ML
021171/004 DEMEROL MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 100MG per ML
040110/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE TABLET/ORAL 50MG
040110/002 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE TABLET/ORAL 100MG
040163/001 MEPERIDINE HYDROCHLORIDE PRESERVATIVE FREE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 10MG per ML
040186/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE TABLET/ORAL 50MG
040186/002 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE TABLET/ORAL 100MG
040191/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE TABLET/ORAL 50MG
040191/002 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE TABLET/ORAL 100MG
040305/001 MEPERIDINE HYDROCHLORIDE PRESERVATIVE FREE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 10MG per ML
040318/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE TABLET/ORAL 50MG
040318/002 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE TABLET/ORAL 100MG
040331/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE TABLET/ORAL 50MG
040331/002 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE TABLET/ORAL 100MG
040352/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE TABLET/ORAL 50MG
040352/002 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE TABLET/ORAL 100MG
040446/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE TABLET/ORAL 50MG
040446/002 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE TABLET/ORAL 100MG
040893/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE TABLET/ORAL 50MG
040893/002 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE TABLET/ORAL 75MG
040893/003 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE TABLET/ORAL 100MG
040893/004 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE TABLET/ORAL 150MG
073443/001 MEPERIDINE HYDROCHLORIDE PRESERVATIVE FREE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 10MG per ML
073444/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 50MG per ML
073445/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 100MG per ML
080364/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 100MG per ML
080364/002 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 50MG per ML
080364/003 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 75MG per ML
080385/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 50MG per ML
080386/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 100MG per ML
080387/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 50MG per ML
080388/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 25MG per ML
080389/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 75MG per ML
080445/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 25MG per ML
080445/002 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 50MG per ML
080445/003 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 75MG per ML
080445/004 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 100MG per ML
080448/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE TABLET/ORAL 50MG
080448/002 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE TABLET/ORAL 100MG
080454/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE TABLET/ORAL 50MG
080455/007 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 25MG per ML
080455/008 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 50MG per ML
080455/009 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 75MG per ML
080455/010 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 100MG per ML
081002/001 MEPERIDINE HYDROCHLORIDE PRESERVATIVE FREE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 10MG per ML
081309/001 MEPERIDINE HYDROCHLORIDE PRESERVATIVE FREE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 10MG per ML
086332/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 10MG per ML
088279/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 25MG per ML
088280/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 50MG per ML
088281/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 75MG per ML
088282/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 100MG per ML
088432/001 MEPERIDINE HYDROCHLORIDE PRESERVATIVE FREE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 10MG per ML
088639/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE TABLET/ORAL 50MG
088640/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE TABLET/ORAL 100MG
088744/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE SYRUP/ORAL 50MG per 5ML
089781/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 25MG per ML
089782/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 50MG per ML
089783/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 50MG per ML
089784/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 50MG per ML
089785/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 75MG per ML
089786/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 100MG per ML
089787/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 100MG per ML
089788/001 MEPERIDINE HYDROCHLORIDE MEPERIDINE HYDROCHLORIDE INJECTABLE/INJECTION 100MG per ML

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Answered questions

Question about the drug demerol/pethidine..?
True John. But at least we know the heroin is being supplied on the black market, not administered illegally by rogue doctors. Asked by Kenton Greenawalt 2 years ago.

Demerol (pethidine/meperidine) is a synthetic opiate analgesic and it is a schedule II drug in The United States, Schedule I in Canada, and Class A in The UK. In just about any country Demerol would fall under the highest levels of control. But it is prescribed for patients all of the time. It is very commonly given (in hospital) for migraine that does not respond to other drugs. Some people doctor shop and get reasonable amount of narcotics from each doctor- but from 4 or 5 doctors and end up with a large amount of drugs. And there are very shady doctors out there who prescribe drugs as if it were nothing, sometimes because they are incompetent other times to satisfy a paying customer. And personal doctors are a bit more likely to doll out whatever the patient "needs." In many cases where The DEA revokes a doctors DEA number (required to give controlled substances) the doctor was giving out drugs in extreme excess. I know of one case where one doctor wrote 90 prescriptions for OxyContin to one person over 6 months or so. Also if you have a good relationship with your doctor and you have known each other for years and years then a doctor would probably be more amiable to prescribe any drug, but only to a point. Most doctors will not prescribe IV Demerol outside of a hospital/hospice. IV opiates are really only needed in emergency situations (morphine for heart attack) or for cancer, AIDS, and other conditions that can cause extreme pain. Answered by Stefany Raver 2 years ago.

I'm not in California but all the states must follow the Federal laws governing narcotics. Demerol is strictly controlled but as in many celebrity situations there are doctors willing to bend the law to be near the limelight.Demerol is rarely used for pain & is given in tablet form by prescription only if other narcotics either don't work or a patient is allergic to codeine, oxycodone, and morphine (doctors better document this too for the Feds will yank their license if they find no records being kept...this applies in all narcotic prescriptions).Demerol is commonly used in hospitals for surgical patients & properly used short term only.It's not good for chronic use. In Hospice we almost never use Demerol for Morphine works much better for chronic pain as does Fentanyl. I've worked as a nurse for over 40 years and anytime someone asked for Demerol...they never got it and were looked on with suspicion for we knew they were addicts.I can truthfully say I've only seen prescriptions for Demerol for anyone outside the hospital setting maybe 6 times, mostly in tablet form & only 12 pills (dentists mostly post extraction).Celebrity Demerol isn't proper medicine. Answered by Parker Sirwet 2 years ago.

It's also strictly controlled in the US. If rumors are even vaguely close to true, then it wouldn't be surprising for MJ's physician to have hired an attorney at least in part because of a risk of losing his narcotic licensure, and perhaps even his license to practice medicine. On the other hand, there is no drug that can't be had by the wealthy or the determined. Certainly even heroin addiction is far from unknown in the UK! Answered by Kristofer Mascagni 2 years ago.

I had an epidural last year and I was numb for a few hours after having my daughter. I had to have the nurses help me walk to the bathroom to take a bath. I dont think everyone is numb for hours I think it depends how long you have the epidural on for. I was in labor for 17 hours and I had the epidural for about 14 hours or so. Dont worry about it, after you give birth you may feel too tired to even get up so dont worry too much. You'll be fine! Answered by Charlie Speciale 2 years ago.

Lestermount Answered by Inga Littledave 2 years ago.


If Demerol is not supposed to used in treating long term pain management, how long would it be used for?
If Demerol is not safe for long term treatment of pain because of toxic buildup what would be the generally accepted period of time that it is safe to use? Would it be days, weeks, etc? The Michael Jackson case has sparked my curiosity. Thank you. Asked by Lavern Snelling 2 years ago.

Demerol is used for the treatment of chronic pain and acute pain. Many doctors prefer Demerol to other opiate analgesics due to some of its unique properties (but it falls more out of favour every year). However, some of its unique properties involving the reuptake of monoamine neurotransmitters (dopamine, serotonin, norepinephrine) and its almost cocaine like stimulation and anesthetic ability (cocaine is a local anesthetic) plus its very fast action makes it more addictive than other IV drugs, it has multiple major drug interactions, does not fully respond to opiate antagonists like Naloxone (for use in OD situations as an antidote), and it is actually toxic (a neurotoxin). One things opiates, especially naturally occurring and semisynthetic opiates, are known for are being "clean" drugs. This means that opiates like morphine do not interact with many neurotransmitters and receptors. So opiates have targeted action. Demerol acts with all sorts of neurotransmitters and has active metabolites that can damage the body. It is almost like morphine and cocaine mixed together hitting the brain in seconds after given IV. Thus it is far more addictive and has the potential for many problems (including cardiac). But it is not exactly a bad drug. Short term use is normally safe and people with certain medical conditions or who do not respond well to morphine and related drugs might use Demerol. It is available in tablet forms that people can take at home for pain. And it is very rare for IV Demerol to be needed except in hospital or home hospice. I can't imagine Jackson was in enough pain that he required daily shots of IV Demerol. Oral pain medication is typically effective in all but extreme situations. Answered by Rosena Hibberd 2 years ago.

Toxic buildup is not the problem, addiction is. Demerol is a derivative of opium, similar to morphine. It is very effective as a pain killer, especially after a surgical procedure. Thus, it is almost ideal for short term use. For reasons that are not completely clear, some persons are more prone to addiction than others. Giving Demerol to these persons over an extended period of time is inadvisable. Many physicians are not astute as to the warning signs. Asking for repeated prescription refills is one huge red flag. Answered by Louie Arguillo 2 years ago.

It is physically addictive and your body begins to build a tolerance to opiates. Over a long period of time the patient will need larger and larger doses of Vicodin to relieve their pain. Answered by Hortencia Seigart 2 years ago.


Does anyone know if there is a doctor that uses Demerol for pain?
I have a lot of headaches for over 40 year now. During my fifteenth year of these headaches I was sitting at work when my head thought it was going to blow apart, I have never in my life had a pain that felt like my brains were going to explode outward, I called my Dad and said :You've got to take me to the... Asked by Aldo Kazemi 2 years ago.

I have a lot of headaches for over 40 year now. During my fifteenth year of these headaches I was sitting at work when my head thought it was going to blow apart, I have never in my life had a pain that felt like my brains were going to explode outward, I called my Dad and said :You've got to take me to the hospital ASAP as I think I am about to die,,,,and I really felt like i was going to die. I was saying my last prayers and I was crying eyes out over all the missed opportunity to do the things I should have done. Then I got to the ER and the doctor gave me a shot of 125 mg Demerol. My dad was in the room with me and I was complaining as to how much my head was still hurt,,,,,ing,,,,did I say HURT ng..........OMG .......it doesn.t hurt anymore...........I can't believe WHAT WAS THAT STUFF????? They told me it was called Demerol. This medicine took my 5 day headache away in 15 minutes. I want to know who has been hiding this stuff all this time. The ER's I go to tell they are using Dilaudid now and phasing out Demerol. That is sad, myself and many , many others believe that Demerol is the best headache medicine out there. If anyone knows which doctor would be willing to administer it, I would very very greatfull and thank you.Thank You and Thank You Answered by Karyl Sperl 2 years ago.

Demerol is still used although its use is in decline. Some hospitals have phased it out and it is not commonly prescribed out patient. Unlike other full opioid agonists (eg methadone, morphine, hydromorphone, oxymorphone) Demerol has a maximum dose, it is significantly neurotoxic and cardiotoxic in even modest doses or when taken too long, it tends to be more abused than other opioids (likely because it has opioid effects and it also has some pharmacological properties of cocaine). Demerol can only be taken for about two weeks at a time whereas most other opioids don't have a limit. I hear similar things from patients all the time. People with extremely severe headaches tend to respond extremely well to Demerol. In addition some consider Demerol to be the best drug to provide the most rapid and effective analgesia. Also hospitals try to avoid using opioids when a patients presents with a headache. However the reality is that opioids are extremely effective treatment to stop the pain once it starts and about 68% of the time opioids are used. People who only have occasional headaches are often prescribed opioids and/or barbiturates because they work so well. If you only have an occasional headache many doctors would likely be willing to prescribe a small number of Demerol tablets (in Canada there are 50 mg tabs and in America I believe there are 50 and 100 mg tabs). And doctors certainly do not administer IV Demerol except in hospital. You are just going to have to see a doctor about treatment. Other medications are something to consider. I will tell you that asking for Demerol and refusing to consider other treatment will make you look like a drug seeker. Answered by Roni Jupin 2 years ago.

Demerol Uses Answered by Serita Silver 2 years ago.

Yes, they are phasing out Demerol permanently because it breaks down in the body into toxic substances. For headaches now they use a mix of Toradol (NSAID), anti nausea med (usually Zofran) and sometimes IV Benedryl. Does the same thing as Demerol for 1/2 the price, AND there are no opiates in any of them, so we can discharge patients faster. Answered by Marcel Harmeyer 2 years ago.

The prescription of meperidine or demerol is for moderate to severe pain. If your pain is really really so bad that you can feel your head bursting open, the pain is even worse than getting your head smashed by a beer bottle you should go to your doctor again to explain the situation. Demerol has too many complication when taken. Answered by Venice Skarupa 2 years ago.


How is Demerol administered--IV, IM, or both. About how much time before side effects would become apparent?
Also, what would be perhaps the initial side effects? Thank you Asked by Katherine Haggin 2 years ago.

Demerol can be given in pill form as well as IM or IV but usually the prescriptions are only given to patients in pill form for obvious reasons since shots & IV use are usually by medical personnel. With pill form usually the effect is felt in 30 minutes after pill dissolves.IV dose is felt within 1-2 minutes.IM dose is usually felt in 15-20 minutes (unless patient has other drugs in the system which may cause it to be earlier).Patients normally start to feel relaxed then say the pain starts to ease off.They often complain of being light headed & sleepy. Literature says the pain is relieved for 4 hours but in my experience patients start to complain of pain again in 3 hours.Demerol is really not a good drug for chronic pain management. Morphine lasts longer & easier to use in terminal patients.Demerol should only be used for short term patients & also not those mixing other opiates. Answered by Tawanna Colee 2 years ago.

This Site Might Help You. RE: How is Demerol administered--IV, IM, or both. About how much time before side effects would become apparent? Also, what would be perhaps the initial side effects? Thank you Answered by Greg Aguilar 2 years ago.

This I happen to know. Demerol can be administered either way. When administered IV, the drug takes effect immediately [depending on the strength] IM, about 15 min. 50mg to 100mg are the preferred dosage. Side effects include foggy brain, thick tongue and not being able to say "no", sexually speaking. I know this first hand. Enjoy the feeling. Answered by Maybelle Olivo 2 years ago.


What does Demerol do? Is it as effective as an epidural?
Asked by Virgie Coghlan 2 years ago.

Demerol is a narcotic that will take the edge off of your pains and makes you feel a little elevated if you will!! It doesn't last that long, maybe an hour or 2 if your lucky and is best used towards the end of your labor as you are only allowed so many doses throughout your labor!! It is not nearly effective as an epidural because with the Demerol, you still feel your contractions, it just takes the edge off of it where as with the epidural, you are completely numb and can't feel anything until they lower your epidural medication!! Answered by Dominga Brittenham 2 years ago.

demerol is a shot that is givenin the arm or hip sometimes given in an IV that is used to dull the pain and relax the mom so she can cope with the pain of contractions it's usually given every 2 to 4 hours.. it makes you feel drowsy it also sometimes causes nauses vomiting and a drop in blood pressure. and it sometimes does effect the babys breathing patterns and ability to suck right after delivery but the side effects wear off.. and epideral is administrated by a large needle into the epideral space of the spine. the needle will insert a small catheter into the space in which the medication will be released... this will numb your lower half of your body.. they can set the drip so you can feel some so your not completely numb to the experience.. from what i've read the only effect this can have on the baby is slowing the heart rate down on some... Answered by Karleen Bengel 2 years ago.

No, all demerol does is make you feel more at ease..kinda high if you will. Epidural is a shot given to you in your back and it numbs your lower body. Answered by Jerold Bjorseth 2 years ago.

No its not as effective as an epidural, demerol makes you groggy and less aware of the situation . epidural makes you numb but doesn't mess iwth your mind state. Answered by Sherice Yarbough 2 years ago.

demerol is nothing like the epidural, opt for the epidural so u can at least be awake when you deliver. Answered by Douglass Grahn 2 years ago.

It makes you drowsy and unaware the epidural numbs from the waist down and doesnt make you drowsy in both births I had epidurals I waouldnt suggest the demoral but everyone is different Answered by Roberto Ajani 2 years ago.

ive had demerol once, non pregnancy related...and im terribly allergic. Apparently. It gave me a really horrible rash, i had to get a shot to make it go away. it was all kinds of bad for me. Answered by Sherlyn Langmaid 2 years ago.


How is Demerol made?
Asked by Ruthann Tok 2 years ago.

Isonicotinic Acid Methochloride. To a slurry of 246 g of isonicotinic acid in 3.2 liters of methanol and 300 ml of water containing 88 g of sodium hydroxide has 355 g of methyl iodide added to it. Note: Isonicotinic acid can be replaced with nicotinic acid, thus producing B-pethidine, instead of demerol. There is very little difference in potency between these two drugs and the formula does not change (just use an equimolar amount of nicotinic acid), so you may use either acid. Stir and reflux the above mixture for 60 hours, then remove the methanol with vacuo. Use sodium thiosulfate to reduce iodine to iodide and add water to give a volume of 1.5 liters. Use hydrochloric acid (concd) to get a ph of 2.0. Place a slurry of Amberlite IRA-400 (6.30 equivalents) in a glass tube 10 cm in diameter and 100 cm high. The resin is washed with 20 x 1. of 5% hydrochloric acid followed with 40 x 1. of distilled water. The yellow aqueous solution is passed through the column and the effluent, which had better be iodine free, is collected at a rate of flow of 50 ml per min. Three and one half liters of effluent is coned and the residue is dried and extracted with acetic acid. Xylene is added to the hot acetic acid solution, then cooled, and saturated with dry hydrogen chloride to give 336 g of crude product. Recrystallize from acetic acid to purify. 1-Methyl-4-carboxypiperidine Hydrochloride. Isonicotinic acid methochloride is quantitively reduced in a high pressure reaction vessel in the presence of platinum oxide in methanol at 1,000 psi, mp: 231-232°. 1-Methyl-4-chloro-4-benzoylpiperidine Hydrochloride. Chlorine gas is slowly passed (bubbled) into a solution of 48 g of the above product in 500 ml of glacial acetic acid for 8 hours at 70°. The volume is evaporated to 150 ml and 1 1iter of dry ether is added. The resulting white powder is recrystallized from chloroform, yielding 45 g of the hydrochloric salt, mp: 181° to 182°. This is then recrystallized from Skelly A, mp: 48-49°C. Rearrangement of 1-Mehtyl-4-chloro-4-benzoylpiperidine. Add 50 ml of xylene (containing 3.5 g of the above product) to a stirred refluxing solution containing 200 ml dry xylene and 18 g of finely powdered, dried sodium NaOH. Stir while refluxing for 30 min, then cool, extract with 25 ml portion of water until the ph of the extracts reaches neutrality (approximately). The combined water extracts are washed with three 25 ml portions of ether and adjusted to 8 ph with hydrochloric acid. The aqueous solution is concentrated to 50 ml (by evaporation in vacuo), filtered, and acidified to 6.5 with hydrochloric acid. The solution is cooled and the crystals are washed with water, acetone, ether, and then dried. Recrystallize from water to get fine, white needles of 1-methyl-4-phenyl-4-carboxy- piperidine. Yield: 0.8 g, mp: 309-310°. This product is then dissolved in ether and treated by passing dry hydrogen chloride through this solution and recrystallizing the resulting salt from acetic acid-benzene. Take the above hydrochloride salt and reflux it in ethanolic hydrogen chloride to get Demerol or analog. Now, you need to know that if you get it wrong, you may end up with a drug that causes irreversible Parkinsonism. If you use too much Demerol, there is a metabolite that will build up and knock off your kidneys. BTW, I left out a step. It's really not something an amateur can cook up. Answered by Karyn Giller 2 years ago.

What Is Demerol Made Of Answered by Criselda Croner 2 years ago.

Active Ingredient: Meperidine Hydrochloride Inactive Ingredients Tablets: Calcium Sulfate, Dibasic Calcium phosphate, Starch, Stearic Acid, Talc. Syrup: Benzoic Acid, Flavor, Liquid Glucose, Purified Water, Saccharin Sodium. Answered by Easter Chatriand 2 years ago.

You dont feel the spinal cathedar once the med takes effect. It can only make labor go longer if there is a lot of meds and the woman cant feel anything, like no pressure. Doesnt matter the baby will come your body will push it out on its own if it had to. It lasts and wears off times differ per person and how often they push the little button to administer more medication. Every Dr and hospital are different some take it out if your going to push because they want you to feel the pressure, some dont mind if the partner is in the room as long as they stay out of the way of the anesthesiologist, but then some have policy that no one but the nurse and anesthesiologist can be in the room with the woman. Mine didnt work with any of my labors and deliveries, many women have epidurals and they work great, many women have them and they dont work at all. just know you did with out before and you were fine, you can do it, but I hope you are able to get a pain med if you want one, they do work wonderfully when they work, good luck~ Answered by Conchita Bessent 2 years ago.

Check out www.wikipedia.com and search for Pethidine. Find the basic ingredients for synthesis then using basic knowledge of synthetic organic chemistry, make some demerol. Oh and by the way, it is illegal to make unless you are a licensed pharmaceutical company. Its not as easy as making crack or meth...so stick to those. And for future reference, please don't ask questions on how to make drugs. Answered by Piedad Hauger 2 years ago.


Question about the drug demerol/pethidine..?
True John. But at least we know the heroin is being supplied on the black market, not administered illegally by rogue doctors. Asked by Merle Headington 2 years ago.

Demerol (pethidine/meperidine) is a synthetic opiate analgesic and it is a schedule II drug in The United States, Schedule I in Canada, and Class A in The UK. In just about any country Demerol would fall under the highest levels of control. But it is prescribed for patients all of the time. It is very commonly given (in hospital) for migraine that does not respond to other drugs. Some people doctor shop and get reasonable amount of narcotics from each doctor- but from 4 or 5 doctors and end up with a large amount of drugs. And there are very shady doctors out there who prescribe drugs as if it were nothing, sometimes because they are incompetent other times to satisfy a paying customer. And personal doctors are a bit more likely to doll out whatever the patient "needs." In many cases where The DEA revokes a doctors DEA number (required to give controlled substances) the doctor was giving out drugs in extreme excess. I know of one case where one doctor wrote 90 prescriptions for OxyContin to one person over 6 months or so. Also if you have a good relationship with your doctor and you have known each other for years and years then a doctor would probably be more amiable to prescribe any drug, but only to a point. Most doctors will not prescribe IV Demerol outside of a hospital/hospice. IV opiates are really only needed in emergency situations (morphine for heart attack) or for cancer, AIDS, and other conditions that can cause extreme pain. Answered by Caren Cenci 2 years ago.

I'm not in California but all the states must follow the Federal laws governing narcotics. Demerol is strictly controlled but as in many celebrity situations there are doctors willing to bend the law to be near the limelight.Demerol is rarely used for pain & is given in tablet form by prescription only if other narcotics either don't work or a patient is allergic to codeine, oxycodone, and morphine (doctors better document this too for the Feds will yank their license if they find no records being kept...this applies in all narcotic prescriptions).Demerol is commonly used in hospitals for surgical patients & properly used short term only.It's not good for chronic use. In Hospice we almost never use Demerol for Morphine works much better for chronic pain as does Fentanyl. I've worked as a nurse for over 40 years and anytime someone asked for Demerol...they never got it and were looked on with suspicion for we knew they were addicts.I can truthfully say I've only seen prescriptions for Demerol for anyone outside the hospital setting maybe 6 times, mostly in tablet form & only 12 pills (dentists mostly post extraction).Celebrity Demerol isn't proper medicine. Answered by Ruthie Tola 2 years ago.

It's also strictly controlled in the US. If rumors are even vaguely close to true, then it wouldn't be surprising for MJ's physician to have hired an attorney at least in part because of a risk of losing his narcotic licensure, and perhaps even his license to practice medicine. On the other hand, there is no drug that can't be had by the wealthy or the determined. Certainly even heroin addiction is far from unknown in the UK! Answered by Gudrun Ohs 2 years ago.

I had an epidural last year and I was numb for a few hours after having my daughter. I had to have the nurses help me walk to the bathroom to take a bath. I dont think everyone is numb for hours I think it depends how long you have the epidural on for. I was in labor for 17 hours and I had the epidural for about 14 hours or so. Dont worry about it, after you give birth you may feel too tired to even get up so dont worry too much. You'll be fine! Answered by Wilhelmina Vanhamlin 2 years ago.

Lestermount Answered by Rickie Benyard 2 years ago.


If Demerol is not supposed to used in treating long term pain management, how long would it be used for?
If Demerol is not safe for long term treatment of pain because of toxic buildup what would be the generally accepted period of time that it is safe to use? Would it be days, weeks, etc? The Michael Jackson case has sparked my curiosity. Thank you. Asked by Natosha Summerhays 2 years ago.

Demerol is used for the treatment of chronic pain and acute pain. Many doctors prefer Demerol to other opiate analgesics due to some of its unique properties (but it falls more out of favour every year). However, some of its unique properties involving the reuptake of monoamine neurotransmitters (dopamine, serotonin, norepinephrine) and its almost cocaine like stimulation and anesthetic ability (cocaine is a local anesthetic) plus its very fast action makes it more addictive than other IV drugs, it has multiple major drug interactions, does not fully respond to opiate antagonists like Naloxone (for use in OD situations as an antidote), and it is actually toxic (a neurotoxin). One things opiates, especially naturally occurring and semisynthetic opiates, are known for are being "clean" drugs. This means that opiates like morphine do not interact with many neurotransmitters and receptors. So opiates have targeted action. Demerol acts with all sorts of neurotransmitters and has active metabolites that can damage the body. It is almost like morphine and cocaine mixed together hitting the brain in seconds after given IV. Thus it is far more addictive and has the potential for many problems (including cardiac). But it is not exactly a bad drug. Short term use is normally safe and people with certain medical conditions or who do not respond well to morphine and related drugs might use Demerol. It is available in tablet forms that people can take at home for pain. And it is very rare for IV Demerol to be needed except in hospital or home hospice. I can't imagine Jackson was in enough pain that he required daily shots of IV Demerol. Oral pain medication is typically effective in all but extreme situations. Answered by Jule Pliska 2 years ago.

Toxic buildup is not the problem, addiction is. Demerol is a derivative of opium, similar to morphine. It is very effective as a pain killer, especially after a surgical procedure. Thus, it is almost ideal for short term use. For reasons that are not completely clear, some persons are more prone to addiction than others. Giving Demerol to these persons over an extended period of time is inadvisable. Many physicians are not astute as to the warning signs. Asking for repeated prescription refills is one huge red flag. Answered by Nadine Dilthey 2 years ago.

It is physically addictive and your body begins to build a tolerance to opiates. Over a long period of time the patient will need larger and larger doses of Vicodin to relieve their pain. Answered by Terica Thackaberry 2 years ago.


Does anyone know if there is a doctor that uses Demerol for pain?
I have a lot of headaches for over 40 year now. During my fifteenth year of these headaches I was sitting at work when my head thought it was going to blow apart, I have never in my life had a pain that felt like my brains were going to explode outward, I called my Dad and said :You've got to take me to the... Asked by Ellis Harmond 2 years ago.

I have a lot of headaches for over 40 year now. During my fifteenth year of these headaches I was sitting at work when my head thought it was going to blow apart, I have never in my life had a pain that felt like my brains were going to explode outward, I called my Dad and said :You've got to take me to the hospital ASAP as I think I am about to die,,,,and I really felt like i was going to die. I was saying my last prayers and I was crying eyes out over all the missed opportunity to do the things I should have done. Then I got to the ER and the doctor gave me a shot of 125 mg Demerol. My dad was in the room with me and I was complaining as to how much my head was still hurt,,,,,ing,,,,did I say HURT ng..........OMG .......it doesn.t hurt anymore...........I can't believe WHAT WAS THAT STUFF????? They told me it was called Demerol. This medicine took my 5 day headache away in 15 minutes. I want to know who has been hiding this stuff all this time. The ER's I go to tell they are using Dilaudid now and phasing out Demerol. That is sad, myself and many , many others believe that Demerol is the best headache medicine out there. If anyone knows which doctor would be willing to administer it, I would very very greatfull and thank you.Thank You and Thank You Answered by Teri Blonsky 2 years ago.

Demerol is still used although its use is in decline. Some hospitals have phased it out and it is not commonly prescribed out patient. Unlike other full opioid agonists (eg methadone, morphine, hydromorphone, oxymorphone) Demerol has a maximum dose, it is significantly neurotoxic and cardiotoxic in even modest doses or when taken too long, it tends to be more abused than other opioids (likely because it has opioid effects and it also has some pharmacological properties of cocaine). Demerol can only be taken for about two weeks at a time whereas most other opioids don't have a limit. I hear similar things from patients all the time. People with extremely severe headaches tend to respond extremely well to Demerol. In addition some consider Demerol to be the best drug to provide the most rapid and effective analgesia. Also hospitals try to avoid using opioids when a patients presents with a headache. However the reality is that opioids are extremely effective treatment to stop the pain once it starts and about 68% of the time opioids are used. People who only have occasional headaches are often prescribed opioids and/or barbiturates because they work so well. If you only have an occasional headache many doctors would likely be willing to prescribe a small number of Demerol tablets (in Canada there are 50 mg tabs and in America I believe there are 50 and 100 mg tabs). And doctors certainly do not administer IV Demerol except in hospital. You are just going to have to see a doctor about treatment. Other medications are something to consider. I will tell you that asking for Demerol and refusing to consider other treatment will make you look like a drug seeker. Answered by Nancee Schantini 2 years ago.

Demerol Uses Answered by Edie Pinta 2 years ago.

Yes, they are phasing out Demerol permanently because it breaks down in the body into toxic substances. For headaches now they use a mix of Toradol (NSAID), anti nausea med (usually Zofran) and sometimes IV Benedryl. Does the same thing as Demerol for 1/2 the price, AND there are no opiates in any of them, so we can discharge patients faster. Answered by Naomi Hopp 2 years ago.

The prescription of meperidine or demerol is for moderate to severe pain. If your pain is really really so bad that you can feel your head bursting open, the pain is even worse than getting your head smashed by a beer bottle you should go to your doctor again to explain the situation. Demerol has too many complication when taken. Answered by Janella Gill 2 years ago.


How is Demerol administered--IV, IM, or both. About how much time before side effects would become apparent?
Also, what would be perhaps the initial side effects? Thank you Asked by Deloise Rabbitt 2 years ago.

Demerol can be given in pill form as well as IM or IV but usually the prescriptions are only given to patients in pill form for obvious reasons since shots & IV use are usually by medical personnel. With pill form usually the effect is felt in 30 minutes after pill dissolves.IV dose is felt within 1-2 minutes.IM dose is usually felt in 15-20 minutes (unless patient has other drugs in the system which may cause it to be earlier).Patients normally start to feel relaxed then say the pain starts to ease off.They often complain of being light headed & sleepy. Literature says the pain is relieved for 4 hours but in my experience patients start to complain of pain again in 3 hours.Demerol is really not a good drug for chronic pain management. Morphine lasts longer & easier to use in terminal patients.Demerol should only be used for short term patients & also not those mixing other opiates. Answered by Anisa Vire 2 years ago.

This Site Might Help You. RE: How is Demerol administered--IV, IM, or both. About how much time before side effects would become apparent? Also, what would be perhaps the initial side effects? Thank you Answered by Josephina Dupuy 2 years ago.

This I happen to know. Demerol can be administered either way. When administered IV, the drug takes effect immediately [depending on the strength] IM, about 15 min. 50mg to 100mg are the preferred dosage. Side effects include foggy brain, thick tongue and not being able to say "no", sexually speaking. I know this first hand. Enjoy the feeling. Answered by Rubin Overy 2 years ago.


What does Demerol do? Is it as effective as an epidural?
Asked by Yajaira Mckibbens 2 years ago.

Demerol is a narcotic that will take the edge off of your pains and makes you feel a little elevated if you will!! It doesn't last that long, maybe an hour or 2 if your lucky and is best used towards the end of your labor as you are only allowed so many doses throughout your labor!! It is not nearly effective as an epidural because with the Demerol, you still feel your contractions, it just takes the edge off of it where as with the epidural, you are completely numb and can't feel anything until they lower your epidural medication!! Answered by Shonna Galban 2 years ago.

demerol is a shot that is givenin the arm or hip sometimes given in an IV that is used to dull the pain and relax the mom so she can cope with the pain of contractions it's usually given every 2 to 4 hours.. it makes you feel drowsy it also sometimes causes nauses vomiting and a drop in blood pressure. and it sometimes does effect the babys breathing patterns and ability to suck right after delivery but the side effects wear off.. and epideral is administrated by a large needle into the epideral space of the spine. the needle will insert a small catheter into the space in which the medication will be released... this will numb your lower half of your body.. they can set the drip so you can feel some so your not completely numb to the experience.. from what i've read the only effect this can have on the baby is slowing the heart rate down on some... Answered by Glen Rattanasinh 2 years ago.

No, all demerol does is make you feel more at ease..kinda high if you will. Epidural is a shot given to you in your back and it numbs your lower body. Answered by Shantae Allgaier 2 years ago.

No its not as effective as an epidural, demerol makes you groggy and less aware of the situation . epidural makes you numb but doesn't mess iwth your mind state. Answered by Catharine Beckes 2 years ago.

demerol is nothing like the epidural, opt for the epidural so u can at least be awake when you deliver. Answered by Madelyn Liebross 2 years ago.

It makes you drowsy and unaware the epidural numbs from the waist down and doesnt make you drowsy in both births I had epidurals I waouldnt suggest the demoral but everyone is different Answered by Diana Glueck 2 years ago.

ive had demerol once, non pregnancy related...and im terribly allergic. Apparently. It gave me a really horrible rash, i had to get a shot to make it go away. it was all kinds of bad for me. Answered by Roseline Marinucci 2 years ago.


How is Demerol made?
Asked by Boris Semsem 2 years ago.

Isonicotinic Acid Methochloride. To a slurry of 246 g of isonicotinic acid in 3.2 liters of methanol and 300 ml of water containing 88 g of sodium hydroxide has 355 g of methyl iodide added to it. Note: Isonicotinic acid can be replaced with nicotinic acid, thus producing B-pethidine, instead of demerol. There is very little difference in potency between these two drugs and the formula does not change (just use an equimolar amount of nicotinic acid), so you may use either acid. Stir and reflux the above mixture for 60 hours, then remove the methanol with vacuo. Use sodium thiosulfate to reduce iodine to iodide and add water to give a volume of 1.5 liters. Use hydrochloric acid (concd) to get a ph of 2.0. Place a slurry of Amberlite IRA-400 (6.30 equivalents) in a glass tube 10 cm in diameter and 100 cm high. The resin is washed with 20 x 1. of 5% hydrochloric acid followed with 40 x 1. of distilled water. The yellow aqueous solution is passed through the column and the effluent, which had better be iodine free, is collected at a rate of flow of 50 ml per min. Three and one half liters of effluent is coned and the residue is dried and extracted with acetic acid. Xylene is added to the hot acetic acid solution, then cooled, and saturated with dry hydrogen chloride to give 336 g of crude product. Recrystallize from acetic acid to purify. 1-Methyl-4-carboxypiperidine Hydrochloride. Isonicotinic acid methochloride is quantitively reduced in a high pressure reaction vessel in the presence of platinum oxide in methanol at 1,000 psi, mp: 231-232°. 1-Methyl-4-chloro-4-benzoylpiperidine Hydrochloride. Chlorine gas is slowly passed (bubbled) into a solution of 48 g of the above product in 500 ml of glacial acetic acid for 8 hours at 70°. The volume is evaporated to 150 ml and 1 1iter of dry ether is added. The resulting white powder is recrystallized from chloroform, yielding 45 g of the hydrochloric salt, mp: 181° to 182°. This is then recrystallized from Skelly A, mp: 48-49°C. Rearrangement of 1-Mehtyl-4-chloro-4-benzoylpiperidine. Add 50 ml of xylene (containing 3.5 g of the above product) to a stirred refluxing solution containing 200 ml dry xylene and 18 g of finely powdered, dried sodium NaOH. Stir while refluxing for 30 min, then cool, extract with 25 ml portion of water until the ph of the extracts reaches neutrality (approximately). The combined water extracts are washed with three 25 ml portions of ether and adjusted to 8 ph with hydrochloric acid. The aqueous solution is concentrated to 50 ml (by evaporation in vacuo), filtered, and acidified to 6.5 with hydrochloric acid. The solution is cooled and the crystals are washed with water, acetone, ether, and then dried. Recrystallize from water to get fine, white needles of 1-methyl-4-phenyl-4-carboxy- piperidine. Yield: 0.8 g, mp: 309-310°. This product is then dissolved in ether and treated by passing dry hydrogen chloride through this solution and recrystallizing the resulting salt from acetic acid-benzene. Take the above hydrochloride salt and reflux it in ethanolic hydrogen chloride to get Demerol or analog. Now, you need to know that if you get it wrong, you may end up with a drug that causes irreversible Parkinsonism. If you use too much Demerol, there is a metabolite that will build up and knock off your kidneys. BTW, I left out a step. It's really not something an amateur can cook up. Answered by Janise Hopkin 2 years ago.

What Is Demerol Made Of Answered by Cecil Delorenzo 2 years ago.

Active Ingredient: Meperidine Hydrochloride Inactive Ingredients Tablets: Calcium Sulfate, Dibasic Calcium phosphate, Starch, Stearic Acid, Talc. Syrup: Benzoic Acid, Flavor, Liquid Glucose, Purified Water, Saccharin Sodium. Answered by Loraine Dandrea 2 years ago.

You dont feel the spinal cathedar once the med takes effect. It can only make labor go longer if there is a lot of meds and the woman cant feel anything, like no pressure. Doesnt matter the baby will come your body will push it out on its own if it had to. It lasts and wears off times differ per person and how often they push the little button to administer more medication. Every Dr and hospital are different some take it out if your going to push because they want you to feel the pressure, some dont mind if the partner is in the room as long as they stay out of the way of the anesthesiologist, but then some have policy that no one but the nurse and anesthesiologist can be in the room with the woman. Mine didnt work with any of my labors and deliveries, many women have epidurals and they work great, many women have them and they dont work at all. just know you did with out before and you were fine, you can do it, but I hope you are able to get a pain med if you want one, they do work wonderfully when they work, good luck~ Answered by Mazie Keef 2 years ago.

Check out www.wikipedia.com and search for Pethidine. Find the basic ingredients for synthesis then using basic knowledge of synthetic organic chemistry, make some demerol. Oh and by the way, it is illegal to make unless you are a licensed pharmaceutical company. Its not as easy as making crack or meth...so stick to those. And for future reference, please don't ask questions on how to make drugs. Answered by Barton Rodemoyer 2 years ago.


Question about the drug demerol/pethidine..?
True John. But at least we know the heroin is being supplied on the black market, not administered illegally by rogue doctors. Asked by Glendora Derobertis 2 years ago.

Demerol (pethidine/meperidine) is a synthetic opiate analgesic and it is a schedule II drug in The United States, Schedule I in Canada, and Class A in The UK. In just about any country Demerol would fall under the highest levels of control. But it is prescribed for patients all of the time. It is very commonly given (in hospital) for migraine that does not respond to other drugs. Some people doctor shop and get reasonable amount of narcotics from each doctor- but from 4 or 5 doctors and end up with a large amount of drugs. And there are very shady doctors out there who prescribe drugs as if it were nothing, sometimes because they are incompetent other times to satisfy a paying customer. And personal doctors are a bit more likely to doll out whatever the patient "needs." In many cases where The DEA revokes a doctors DEA number (required to give controlled substances) the doctor was giving out drugs in extreme excess. I know of one case where one doctor wrote 90 prescriptions for OxyContin to one person over 6 months or so. Also if you have a good relationship with your doctor and you have known each other for years and years then a doctor would probably be more amiable to prescribe any drug, but only to a point. Most doctors will not prescribe IV Demerol outside of a hospital/hospice. IV opiates are really only needed in emergency situations (morphine for heart attack) or for cancer, AIDS, and other conditions that can cause extreme pain. Answered by Jefferson Andreessen 2 years ago.

I'm not in California but all the states must follow the Federal laws governing narcotics. Demerol is strictly controlled but as in many celebrity situations there are doctors willing to bend the law to be near the limelight.Demerol is rarely used for pain & is given in tablet form by prescription only if other narcotics either don't work or a patient is allergic to codeine, oxycodone, and morphine (doctors better document this too for the Feds will yank their license if they find no records being kept...this applies in all narcotic prescriptions).Demerol is commonly used in hospitals for surgical patients & properly used short term only.It's not good for chronic use. In Hospice we almost never use Demerol for Morphine works much better for chronic pain as does Fentanyl. I've worked as a nurse for over 40 years and anytime someone asked for Demerol...they never got it and were looked on with suspicion for we knew they were addicts.I can truthfully say I've only seen prescriptions for Demerol for anyone outside the hospital setting maybe 6 times, mostly in tablet form & only 12 pills (dentists mostly post extraction).Celebrity Demerol isn't proper medicine. Answered by Kattie Quenzel 2 years ago.

It's also strictly controlled in the US. If rumors are even vaguely close to true, then it wouldn't be surprising for MJ's physician to have hired an attorney at least in part because of a risk of losing his narcotic licensure, and perhaps even his license to practice medicine. On the other hand, there is no drug that can't be had by the wealthy or the determined. Certainly even heroin addiction is far from unknown in the UK! Answered by Lidia Fettes 2 years ago.

I had an epidural last year and I was numb for a few hours after having my daughter. I had to have the nurses help me walk to the bathroom to take a bath. I dont think everyone is numb for hours I think it depends how long you have the epidural on for. I was in labor for 17 hours and I had the epidural for about 14 hours or so. Dont worry about it, after you give birth you may feel too tired to even get up so dont worry too much. You'll be fine! Answered by Naoma Oesterle 2 years ago.

Lestermount Answered by Guadalupe Billotti 2 years ago.


If Demerol is not supposed to used in treating long term pain management, how long would it be used for?
If Demerol is not safe for long term treatment of pain because of toxic buildup what would be the generally accepted period of time that it is safe to use? Would it be days, weeks, etc? The Michael Jackson case has sparked my curiosity. Thank you. Asked by Tashina Nuccitelli 2 years ago.

Demerol is used for the treatment of chronic pain and acute pain. Many doctors prefer Demerol to other opiate analgesics due to some of its unique properties (but it falls more out of favour every year). However, some of its unique properties involving the reuptake of monoamine neurotransmitters (dopamine, serotonin, norepinephrine) and its almost cocaine like stimulation and anesthetic ability (cocaine is a local anesthetic) plus its very fast action makes it more addictive than other IV drugs, it has multiple major drug interactions, does not fully respond to opiate antagonists like Naloxone (for use in OD situations as an antidote), and it is actually toxic (a neurotoxin). One things opiates, especially naturally occurring and semisynthetic opiates, are known for are being "clean" drugs. This means that opiates like morphine do not interact with many neurotransmitters and receptors. So opiates have targeted action. Demerol acts with all sorts of neurotransmitters and has active metabolites that can damage the body. It is almost like morphine and cocaine mixed together hitting the brain in seconds after given IV. Thus it is far more addictive and has the potential for many problems (including cardiac). But it is not exactly a bad drug. Short term use is normally safe and people with certain medical conditions or who do not respond well to morphine and related drugs might use Demerol. It is available in tablet forms that people can take at home for pain. And it is very rare for IV Demerol to be needed except in hospital or home hospice. I can't imagine Jackson was in enough pain that he required daily shots of IV Demerol. Oral pain medication is typically effective in all but extreme situations. Answered by Terrell Selover 2 years ago.

Toxic buildup is not the problem, addiction is. Demerol is a derivative of opium, similar to morphine. It is very effective as a pain killer, especially after a surgical procedure. Thus, it is almost ideal for short term use. For reasons that are not completely clear, some persons are more prone to addiction than others. Giving Demerol to these persons over an extended period of time is inadvisable. Many physicians are not astute as to the warning signs. Asking for repeated prescription refills is one huge red flag. Answered by Antonio Knipe 2 years ago.

It is physically addictive and your body begins to build a tolerance to opiates. Over a long period of time the patient will need larger and larger doses of Vicodin to relieve their pain. Answered by Estefana Maeweather 2 years ago.


Does anyone know if there is a doctor that uses Demerol for pain?
I have a lot of headaches for over 40 year now. During my fifteenth year of these headaches I was sitting at work when my head thought it was going to blow apart, I have never in my life had a pain that felt like my brains were going to explode outward, I called my Dad and said :You've got to take me to the... Asked by Jeromy Medellin 2 years ago.

I have a lot of headaches for over 40 year now. During my fifteenth year of these headaches I was sitting at work when my head thought it was going to blow apart, I have never in my life had a pain that felt like my brains were going to explode outward, I called my Dad and said :You've got to take me to the hospital ASAP as I think I am about to die,,,,and I really felt like i was going to die. I was saying my last prayers and I was crying eyes out over all the missed opportunity to do the things I should have done. Then I got to the ER and the doctor gave me a shot of 125 mg Demerol. My dad was in the room with me and I was complaining as to how much my head was still hurt,,,,,ing,,,,did I say HURT ng..........OMG .......it doesn.t hurt anymore...........I can't believe WHAT WAS THAT STUFF????? They told me it was called Demerol. This medicine took my 5 day headache away in 15 minutes. I want to know who has been hiding this stuff all this time. The ER's I go to tell they are using Dilaudid now and phasing out Demerol. That is sad, myself and many , many others believe that Demerol is the best headache medicine out there. If anyone knows which doctor would be willing to administer it, I would very very greatfull and thank you.Thank You and Thank You Answered by Tyra Kutchie 2 years ago.

Demerol is still used although its use is in decline. Some hospitals have phased it out and it is not commonly prescribed out patient. Unlike other full opioid agonists (eg methadone, morphine, hydromorphone, oxymorphone) Demerol has a maximum dose, it is significantly neurotoxic and cardiotoxic in even modest doses or when taken too long, it tends to be more abused than other opioids (likely because it has opioid effects and it also has some pharmacological properties of cocaine). Demerol can only be taken for about two weeks at a time whereas most other opioids don't have a limit. I hear similar things from patients all the time. People with extremely severe headaches tend to respond extremely well to Demerol. In addition some consider Demerol to be the best drug to provide the most rapid and effective analgesia. Also hospitals try to avoid using opioids when a patients presents with a headache. However the reality is that opioids are extremely effective treatment to stop the pain once it starts and about 68% of the time opioids are used. People who only have occasional headaches are often prescribed opioids and/or barbiturates because they work so well. If you only have an occasional headache many doctors would likely be willing to prescribe a small number of Demerol tablets (in Canada there are 50 mg tabs and in America I believe there are 50 and 100 mg tabs). And doctors certainly do not administer IV Demerol except in hospital. You are just going to have to see a doctor about treatment. Other medications are something to consider. I will tell you that asking for Demerol and refusing to consider other treatment will make you look like a drug seeker. Answered by Ethyl Lutz 2 years ago.

Demerol Uses Answered by Bud Spelman 2 years ago.

Yes, they are phasing out Demerol permanently because it breaks down in the body into toxic substances. For headaches now they use a mix of Toradol (NSAID), anti nausea med (usually Zofran) and sometimes IV Benedryl. Does the same thing as Demerol for 1/2 the price, AND there are no opiates in any of them, so we can discharge patients faster. Answered by Michel Rinderle 2 years ago.

The prescription of meperidine or demerol is for moderate to severe pain. If your pain is really really so bad that you can feel your head bursting open, the pain is even worse than getting your head smashed by a beer bottle you should go to your doctor again to explain the situation. Demerol has too many complication when taken. Answered by Annis Koening 2 years ago.


How is Demerol administered--IV, IM, or both. About how much time before side effects would become apparent?
Also, what would be perhaps the initial side effects? Thank you Asked by Carol Karangelen 2 years ago.

Demerol can be given in pill form as well as IM or IV but usually the prescriptions are only given to patients in pill form for obvious reasons since shots & IV use are usually by medical personnel. With pill form usually the effect is felt in 30 minutes after pill dissolves.IV dose is felt within 1-2 minutes.IM dose is usually felt in 15-20 minutes (unless patient has other drugs in the system which may cause it to be earlier).Patients normally start to feel relaxed then say the pain starts to ease off.They often complain of being light headed & sleepy. Literature says the pain is relieved for 4 hours but in my experience patients start to complain of pain again in 3 hours.Demerol is really not a good drug for chronic pain management. Morphine lasts longer & easier to use in terminal patients.Demerol should only be used for short term patients & also not those mixing other opiates. Answered by Lea Light 2 years ago.

This Site Might Help You. RE: How is Demerol administered--IV, IM, or both. About how much time before side effects would become apparent? Also, what would be perhaps the initial side effects? Thank you Answered by Vanesa Sifers 2 years ago.

This I happen to know. Demerol can be administered either way. When administered IV, the drug takes effect immediately [depending on the strength] IM, about 15 min. 50mg to 100mg are the preferred dosage. Side effects include foggy brain, thick tongue and not being able to say "no", sexually speaking. I know this first hand. Enjoy the feeling. Answered by Adalberto Ork 2 years ago.


What does Demerol do? Is it as effective as an epidural?
Asked by Roosevelt Boschert 2 years ago.

Demerol is a narcotic that will take the edge off of your pains and makes you feel a little elevated if you will!! It doesn't last that long, maybe an hour or 2 if your lucky and is best used towards the end of your labor as you are only allowed so many doses throughout your labor!! It is not nearly effective as an epidural because with the Demerol, you still feel your contractions, it just takes the edge off of it where as with the epidural, you are completely numb and can't feel anything until they lower your epidural medication!! Answered by Jen Kuhlo 2 years ago.

demerol is a shot that is givenin the arm or hip sometimes given in an IV that is used to dull the pain and relax the mom so she can cope with the pain of contractions it's usually given every 2 to 4 hours.. it makes you feel drowsy it also sometimes causes nauses vomiting and a drop in blood pressure. and it sometimes does effect the babys breathing patterns and ability to suck right after delivery but the side effects wear off.. and epideral is administrated by a large needle into the epideral space of the spine. the needle will insert a small catheter into the space in which the medication will be released... this will numb your lower half of your body.. they can set the drip so you can feel some so your not completely numb to the experience.. from what i've read the only effect this can have on the baby is slowing the heart rate down on some... Answered by Duane Loveland 2 years ago.

No, all demerol does is make you feel more at ease..kinda high if you will. Epidural is a shot given to you in your back and it numbs your lower body. Answered by Christian Wongus 2 years ago.

No its not as effective as an epidural, demerol makes you groggy and less aware of the situation . epidural makes you numb but doesn't mess iwth your mind state. Answered by Marvin Lofthus 2 years ago.

demerol is nothing like the epidural, opt for the epidural so u can at least be awake when you deliver. Answered by Emeline Krentz 2 years ago.

It makes you drowsy and unaware the epidural numbs from the waist down and doesnt make you drowsy in both births I had epidurals I waouldnt suggest the demoral but everyone is different Answered by Rhonda Krukowski 2 years ago.

ive had demerol once, non pregnancy related...and im terribly allergic. Apparently. It gave me a really horrible rash, i had to get a shot to make it go away. it was all kinds of bad for me. Answered by Kena Monot 2 years ago.


How is Demerol made?
Asked by Hank Kolikas 2 years ago.

Isonicotinic Acid Methochloride. To a slurry of 246 g of isonicotinic acid in 3.2 liters of methanol and 300 ml of water containing 88 g of sodium hydroxide has 355 g of methyl iodide added to it. Note: Isonicotinic acid can be replaced with nicotinic acid, thus producing B-pethidine, instead of demerol. There is very little difference in potency between these two drugs and the formula does not change (just use an equimolar amount of nicotinic acid), so you may use either acid. Stir and reflux the above mixture for 60 hours, then remove the methanol with vacuo. Use sodium thiosulfate to reduce iodine to iodide and add water to give a volume of 1.5 liters. Use hydrochloric acid (concd) to get a ph of 2.0. Place a slurry of Amberlite IRA-400 (6.30 equivalents) in a glass tube 10 cm in diameter and 100 cm high. The resin is washed with 20 x 1. of 5% hydrochloric acid followed with 40 x 1. of distilled water. The yellow aqueous solution is passed through the column and the effluent, which had better be iodine free, is collected at a rate of flow of 50 ml per min. Three and one half liters of effluent is coned and the residue is dried and extracted with acetic acid. Xylene is added to the hot acetic acid solution, then cooled, and saturated with dry hydrogen chloride to give 336 g of crude product. Recrystallize from acetic acid to purify. 1-Methyl-4-carboxypiperidine Hydrochloride. Isonicotinic acid methochloride is quantitively reduced in a high pressure reaction vessel in the presence of platinum oxide in methanol at 1,000 psi, mp: 231-232°. 1-Methyl-4-chloro-4-benzoylpiperidine Hydrochloride. Chlorine gas is slowly passed (bubbled) into a solution of 48 g of the above product in 500 ml of glacial acetic acid for 8 hours at 70°. The volume is evaporated to 150 ml and 1 1iter of dry ether is added. The resulting white powder is recrystallized from chloroform, yielding 45 g of the hydrochloric salt, mp: 181° to 182°. This is then recrystallized from Skelly A, mp: 48-49°C. Rearrangement of 1-Mehtyl-4-chloro-4-benzoylpiperidine. Add 50 ml of xylene (containing 3.5 g of the above product) to a stirred refluxing solution containing 200 ml dry xylene and 18 g of finely powdered, dried sodium NaOH. Stir while refluxing for 30 min, then cool, extract with 25 ml portion of water until the ph of the extracts reaches neutrality (approximately). The combined water extracts are washed with three 25 ml portions of ether and adjusted to 8 ph with hydrochloric acid. The aqueous solution is concentrated to 50 ml (by evaporation in vacuo), filtered, and acidified to 6.5 with hydrochloric acid. The solution is cooled and the crystals are washed with water, acetone, ether, and then dried. Recrystallize from water to get fine, white needles of 1-methyl-4-phenyl-4-carboxy- piperidine. Yield: 0.8 g, mp: 309-310°. This product is then dissolved in ether and treated by passing dry hydrogen chloride through this solution and recrystallizing the resulting salt from acetic acid-benzene. Take the above hydrochloride salt and reflux it in ethanolic hydrogen chloride to get Demerol or analog. Now, you need to know that if you get it wrong, you may end up with a drug that causes irreversible Parkinsonism. If you use too much Demerol, there is a metabolite that will build up and knock off your kidneys. BTW, I left out a step. It's really not something an amateur can cook up. Answered by Dion Mayher 2 years ago.

What Is Demerol Made Of Answered by Dewitt Binegar 2 years ago.

Active Ingredient: Meperidine Hydrochloride Inactive Ingredients Tablets: Calcium Sulfate, Dibasic Calcium phosphate, Starch, Stearic Acid, Talc. Syrup: Benzoic Acid, Flavor, Liquid Glucose, Purified Water, Saccharin Sodium. Answered by Michelle Swimmer 2 years ago.

You dont feel the spinal cathedar once the med takes effect. It can only make labor go longer if there is a lot of meds and the woman cant feel anything, like no pressure. Doesnt matter the baby will come your body will push it out on its own if it had to. It lasts and wears off times differ per person and how often they push the little button to administer more medication. Every Dr and hospital are different some take it out if your going to push because they want you to feel the pressure, some dont mind if the partner is in the room as long as they stay out of the way of the anesthesiologist, but then some have policy that no one but the nurse and anesthesiologist can be in the room with the woman. Mine didnt work with any of my labors and deliveries, many women have epidurals and they work great, many women have them and they dont work at all. just know you did with out before and you were fine, you can do it, but I hope you are able to get a pain med if you want one, they do work wonderfully when they work, good luck~ Answered by Kiersten Kitching 2 years ago.

Check out www.wikipedia.com and search for Pethidine. Find the basic ingredients for synthesis then using basic knowledge of synthetic organic chemistry, make some demerol. Oh and by the way, it is illegal to make unless you are a licensed pharmaceutical company. Its not as easy as making crack or meth...so stick to those. And for future reference, please don't ask questions on how to make drugs. Answered by Amos Hearston 2 years ago.


Question about the drug demerol/pethidine..?
True John. But at least we know the heroin is being supplied on the black market, not administered illegally by rogue doctors. Asked by Tory Peregrino 2 years ago.

Demerol (pethidine/meperidine) is a synthetic opiate analgesic and it is a schedule II drug in The United States, Schedule I in Canada, and Class A in The UK. In just about any country Demerol would fall under the highest levels of control. But it is prescribed for patients all of the time. It is very commonly given (in hospital) for migraine that does not respond to other drugs. Some people doctor shop and get reasonable amount of narcotics from each doctor- but from 4 or 5 doctors and end up with a large amount of drugs. And there are very shady doctors out there who prescribe drugs as if it were nothing, sometimes because they are incompetent other times to satisfy a paying customer. And personal doctors are a bit more likely to doll out whatever the patient "needs." In many cases where The DEA revokes a doctors DEA number (required to give controlled substances) the doctor was giving out drugs in extreme excess. I know of one case where one doctor wrote 90 prescriptions for OxyContin to one person over 6 months or so. Also if you have a good relationship with your doctor and you have known each other for years and years then a doctor would probably be more amiable to prescribe any drug, but only to a point. Most doctors will not prescribe IV Demerol outside of a hospital/hospice. IV opiates are really only needed in emergency situations (morphine for heart attack) or for cancer, AIDS, and other conditions that can cause extreme pain. Answered by Corey Kurdyla 2 years ago.

I'm not in California but all the states must follow the Federal laws governing narcotics. Demerol is strictly controlled but as in many celebrity situations there are doctors willing to bend the law to be near the limelight.Demerol is rarely used for pain & is given in tablet form by prescription only if other narcotics either don't work or a patient is allergic to codeine, oxycodone, and morphine (doctors better document this too for the Feds will yank their license if they find no records being kept...this applies in all narcotic prescriptions).Demerol is commonly used in hospitals for surgical patients & properly used short term only.It's not good for chronic use. In Hospice we almost never use Demerol for Morphine works much better for chronic pain as does Fentanyl. I've worked as a nurse for over 40 years and anytime someone asked for Demerol...they never got it and were looked on with suspicion for we knew they were addicts.I can truthfully say I've only seen prescriptions for Demerol for anyone outside the hospital setting maybe 6 times, mostly in tablet form & only 12 pills (dentists mostly post extraction).Celebrity Demerol isn't proper medicine. Answered by Laurence Tobolski 2 years ago.

It's also strictly controlled in the US. If rumors are even vaguely close to true, then it wouldn't be surprising for MJ's physician to have hired an attorney at least in part because of a risk of losing his narcotic licensure, and perhaps even his license to practice medicine. On the other hand, there is no drug that can't be had by the wealthy or the determined. Certainly even heroin addiction is far from unknown in the UK! Answered by Stephany Fortson 2 years ago.

I had an epidural last year and I was numb for a few hours after having my daughter. I had to have the nurses help me walk to the bathroom to take a bath. I dont think everyone is numb for hours I think it depends how long you have the epidural on for. I was in labor for 17 hours and I had the epidural for about 14 hours or so. Dont worry about it, after you give birth you may feel too tired to even get up so dont worry too much. You'll be fine! Answered by Paul Debell 2 years ago.

Lestermount Answered by Bobbie Kato 2 years ago.


If Demerol is not supposed to used in treating long term pain management, how long would it be used for?
If Demerol is not safe for long term treatment of pain because of toxic buildup what would be the generally accepted period of time that it is safe to use? Would it be days, weeks, etc? The Michael Jackson case has sparked my curiosity. Thank you. Asked by Juliane Felux 2 years ago.

Demerol is used for the treatment of chronic pain and acute pain. Many doctors prefer Demerol to other opiate analgesics due to some of its unique properties (but it falls more out of favour every year). However, some of its unique properties involving the reuptake of monoamine neurotransmitters (dopamine, serotonin, norepinephrine) and its almost cocaine like stimulation and anesthetic ability (cocaine is a local anesthetic) plus its very fast action makes it more addictive than other IV drugs, it has multiple major drug interactions, does not fully respond to opiate antagonists like Naloxone (for use in OD situations as an antidote), and it is actually toxic (a neurotoxin). One things opiates, especially naturally occurring and semisynthetic opiates, are known for are being "clean" drugs. This means that opiates like morphine do not interact with many neurotransmitters and receptors. So opiates have targeted action. Demerol acts with all sorts of neurotransmitters and has active metabolites that can damage the body. It is almost like morphine and cocaine mixed together hitting the brain in seconds after given IV. Thus it is far more addictive and has the potential for many problems (including cardiac). But it is not exactly a bad drug. Short term use is normally safe and people with certain medical conditions or who do not respond well to morphine and related drugs might use Demerol. It is available in tablet forms that people can take at home for pain. And it is very rare for IV Demerol to be needed except in hospital or home hospice. I can't imagine Jackson was in enough pain that he required daily shots of IV Demerol. Oral pain medication is typically effective in all but extreme situations. Answered by Hipolito Halloway 2 years ago.

Toxic buildup is not the problem, addiction is. Demerol is a derivative of opium, similar to morphine. It is very effective as a pain killer, especially after a surgical procedure. Thus, it is almost ideal for short term use. For reasons that are not completely clear, some persons are more prone to addiction than others. Giving Demerol to these persons over an extended period of time is inadvisable. Many physicians are not astute as to the warning signs. Asking for repeated prescription refills is one huge red flag. Answered by Tommie Sy 2 years ago.

It is physically addictive and your body begins to build a tolerance to opiates. Over a long period of time the patient will need larger and larger doses of Vicodin to relieve their pain. Answered by Daniel Tsistinas 2 years ago.


Does anyone know if there is a doctor that uses Demerol for pain?
I have a lot of headaches for over 40 year now. During my fifteenth year of these headaches I was sitting at work when my head thought it was going to blow apart, I have never in my life had a pain that felt like my brains were going to explode outward, I called my Dad and said :You've got to take me to the... Asked by Shelly Hailstone 2 years ago.

I have a lot of headaches for over 40 year now. During my fifteenth year of these headaches I was sitting at work when my head thought it was going to blow apart, I have never in my life had a pain that felt like my brains were going to explode outward, I called my Dad and said :You've got to take me to the hospital ASAP as I think I am about to die,,,,and I really felt like i was going to die. I was saying my last prayers and I was crying eyes out over all the missed opportunity to do the things I should have done. Then I got to the ER and the doctor gave me a shot of 125 mg Demerol. My dad was in the room with me and I was complaining as to how much my head was still hurt,,,,,ing,,,,did I say HURT ng..........OMG .......it doesn.t hurt anymore...........I can't believe WHAT WAS THAT STUFF????? They told me it was called Demerol. This medicine took my 5 day headache away in 15 minutes. I want to know who has been hiding this stuff all this time. The ER's I go to tell they are using Dilaudid now and phasing out Demerol. That is sad, myself and many , many others believe that Demerol is the best headache medicine out there. If anyone knows which doctor would be willing to administer it, I would very very greatfull and thank you.Thank You and Thank You Answered by Denis Begnoche 2 years ago.

Demerol is still used although its use is in decline. Some hospitals have phased it out and it is not commonly prescribed out patient. Unlike other full opioid agonists (eg methadone, morphine, hydromorphone, oxymorphone) Demerol has a maximum dose, it is significantly neurotoxic and cardiotoxic in even modest doses or when taken too long, it tends to be more abused than other opioids (likely because it has opioid effects and it also has some pharmacological properties of cocaine). Demerol can only be taken for about two weeks at a time whereas most other opioids don't have a limit. I hear similar things from patients all the time. People with extremely severe headaches tend to respond extremely well to Demerol. In addition some consider Demerol to be the best drug to provide the most rapid and effective analgesia. Also hospitals try to avoid using opioids when a patients presents with a headache. However the reality is that opioids are extremely effective treatment to stop the pain once it starts and about 68% of the time opioids are used. People who only have occasional headaches are often prescribed opioids and/or barbiturates because they work so well. If you only have an occasional headache many doctors would likely be willing to prescribe a small number of Demerol tablets (in Canada there are 50 mg tabs and in America I believe there are 50 and 100 mg tabs). And doctors certainly do not administer IV Demerol except in hospital. You are just going to have to see a doctor about treatment. Other medications are something to consider. I will tell you that asking for Demerol and refusing to consider other treatment will make you look like a drug seeker. Answered by Efren Younge 2 years ago.

Demerol Uses Answered by Rashad Cullen 2 years ago.

Yes, they are phasing out Demerol permanently because it breaks down in the body into toxic substances. For headaches now they use a mix of Toradol (NSAID), anti nausea med (usually Zofran) and sometimes IV Benedryl. Does the same thing as Demerol for 1/2 the price, AND there are no opiates in any of them, so we can discharge patients faster. Answered by Maryanne Ostenberg 2 years ago.

The prescription of meperidine or demerol is for moderate to severe pain. If your pain is really really so bad that you can feel your head bursting open, the pain is even worse than getting your head smashed by a beer bottle you should go to your doctor again to explain the situation. Demerol has too many complication when taken. Answered by Ai Siona 2 years ago.


How is Demerol administered--IV, IM, or both. About how much time before side effects would become apparent?
Also, what would be perhaps the initial side effects? Thank you Asked by Lorine Osthoff 2 years ago.

Demerol can be given in pill form as well as IM or IV but usually the prescriptions are only given to patients in pill form for obvious reasons since shots & IV use are usually by medical personnel. With pill form usually the effect is felt in 30 minutes after pill dissolves.IV dose is felt within 1-2 minutes.IM dose is usually felt in 15-20 minutes (unless patient has other drugs in the system which may cause it to be earlier).Patients normally start to feel relaxed then say the pain starts to ease off.They often complain of being light headed & sleepy. Literature says the pain is relieved for 4 hours but in my experience patients start to complain of pain again in 3 hours.Demerol is really not a good drug for chronic pain management. Morphine lasts longer & easier to use in terminal patients.Demerol should only be used for short term patients & also not those mixing other opiates. Answered by Lucio Burlock 2 years ago.

This Site Might Help You. RE: How is Demerol administered--IV, IM, or both. About how much time before side effects would become apparent? Also, what would be perhaps the initial side effects? Thank you Answered by Marketta Mikler 2 years ago.

This I happen to know. Demerol can be administered either way. When administered IV, the drug takes effect immediately [depending on the strength] IM, about 15 min. 50mg to 100mg are the preferred dosage. Side effects include foggy brain, thick tongue and not being able to say "no", sexually speaking. I know this first hand. Enjoy the feeling. Answered by Taina Mehringer 2 years ago.


What does Demerol do? Is it as effective as an epidural?
Asked by Elly Chewning 2 years ago.

Demerol is a narcotic that will take the edge off of your pains and makes you feel a little elevated if you will!! It doesn't last that long, maybe an hour or 2 if your lucky and is best used towards the end of your labor as you are only allowed so many doses throughout your labor!! It is not nearly effective as an epidural because with the Demerol, you still feel your contractions, it just takes the edge off of it where as with the epidural, you are completely numb and can't feel anything until they lower your epidural medication!! Answered by Tamisha Mcquage 2 years ago.

demerol is a shot that is givenin the arm or hip sometimes given in an IV that is used to dull the pain and relax the mom so she can cope with the pain of contractions it's usually given every 2 to 4 hours.. it makes you feel drowsy it also sometimes causes nauses vomiting and a drop in blood pressure. and it sometimes does effect the babys breathing patterns and ability to suck right after delivery but the side effects wear off.. and epideral is administrated by a large needle into the epideral space of the spine. the needle will insert a small catheter into the space in which the medication will be released... this will numb your lower half of your body.. they can set the drip so you can feel some so your not completely numb to the experience.. from what i've read the only effect this can have on the baby is slowing the heart rate down on some... Answered by Noble Merryman 2 years ago.

No, all demerol does is make you feel more at ease..kinda high if you will. Epidural is a shot given to you in your back and it numbs your lower body. Answered by Alexandra Kennamer 2 years ago.

No its not as effective as an epidural, demerol makes you groggy and less aware of the situation . epidural makes you numb but doesn't mess iwth your mind state. Answered by Fredric Bault 2 years ago.

demerol is nothing like the epidural, opt for the epidural so u can at least be awake when you deliver. Answered by Latricia Pinn 2 years ago.

It makes you drowsy and unaware the epidural numbs from the waist down and doesnt make you drowsy in both births I had epidurals I waouldnt suggest the demoral but everyone is different Answered by Isabel Medeiras 2 years ago.

ive had demerol once, non pregnancy related...and im terribly allergic. Apparently. It gave me a really horrible rash, i had to get a shot to make it go away. it was all kinds of bad for me. Answered by Adaline Cotillo 2 years ago.


How is Demerol made?
Asked by Rachael Kresal 2 years ago.

Isonicotinic Acid Methochloride. To a slurry of 246 g of isonicotinic acid in 3.2 liters of methanol and 300 ml of water containing 88 g of sodium hydroxide has 355 g of methyl iodide added to it. Note: Isonicotinic acid can be replaced with nicotinic acid, thus producing B-pethidine, instead of demerol. There is very little difference in potency between these two drugs and the formula does not change (just use an equimolar amount of nicotinic acid), so you may use either acid. Stir and reflux the above mixture for 60 hours, then remove the methanol with vacuo. Use sodium thiosulfate to reduce iodine to iodide and add water to give a volume of 1.5 liters. Use hydrochloric acid (concd) to get a ph of 2.0. Place a slurry of Amberlite IRA-400 (6.30 equivalents) in a glass tube 10 cm in diameter and 100 cm high. The resin is washed with 20 x 1. of 5% hydrochloric acid followed with 40 x 1. of distilled water. The yellow aqueous solution is passed through the column and the effluent, which had better be iodine free, is collected at a rate of flow of 50 ml per min. Three and one half liters of effluent is coned and the residue is dried and extracted with acetic acid. Xylene is added to the hot acetic acid solution, then cooled, and saturated with dry hydrogen chloride to give 336 g of crude product. Recrystallize from acetic acid to purify. 1-Methyl-4-carboxypiperidine Hydrochloride. Isonicotinic acid methochloride is quantitively reduced in a high pressure reaction vessel in the presence of platinum oxide in methanol at 1,000 psi, mp: 231-232°. 1-Methyl-4-chloro-4-benzoylpiperidine Hydrochloride. Chlorine gas is slowly passed (bubbled) into a solution of 48 g of the above product in 500 ml of glacial acetic acid for 8 hours at 70°. The volume is evaporated to 150 ml and 1 1iter of dry ether is added. The resulting white powder is recrystallized from chloroform, yielding 45 g of the hydrochloric salt, mp: 181° to 182°. This is then recrystallized from Skelly A, mp: 48-49°C. Rearrangement of 1-Mehtyl-4-chloro-4-benzoylpiperidine. Add 50 ml of xylene (containing 3.5 g of the above product) to a stirred refluxing solution containing 200 ml dry xylene and 18 g of finely powdered, dried sodium NaOH. Stir while refluxing for 30 min, then cool, extract with 25 ml portion of water until the ph of the extracts reaches neutrality (approximately). The combined water extracts are washed with three 25 ml portions of ether and adjusted to 8 ph with hydrochloric acid. The aqueous solution is concentrated to 50 ml (by evaporation in vacuo), filtered, and acidified to 6.5 with hydrochloric acid. The solution is cooled and the crystals are washed with water, acetone, ether, and then dried. Recrystallize from water to get fine, white needles of 1-methyl-4-phenyl-4-carboxy- piperidine. Yield: 0.8 g, mp: 309-310°. This product is then dissolved in ether and treated by passing dry hydrogen chloride through this solution and recrystallizing the resulting salt from acetic acid-benzene. Take the above hydrochloride salt and reflux it in ethanolic hydrogen chloride to get Demerol or analog. Now, you need to know that if you get it wrong, you may end up with a drug that causes irreversible Parkinsonism. If you use too much Demerol, there is a metabolite that will build up and knock off your kidneys. BTW, I left out a step. It's really not something an amateur can cook up. Answered by Maryellen Chatt 2 years ago.

What Is Demerol Made Of Answered by Gina Chiaminto 2 years ago.

Active Ingredient: Meperidine Hydrochloride Inactive Ingredients Tablets: Calcium Sulfate, Dibasic Calcium phosphate, Starch, Stearic Acid, Talc. Syrup: Benzoic Acid, Flavor, Liquid Glucose, Purified Water, Saccharin Sodium. Answered by Nichelle Juste 2 years ago.

You dont feel the spinal cathedar once the med takes effect. It can only make labor go longer if there is a lot of meds and the woman cant feel anything, like no pressure. Doesnt matter the baby will come your body will push it out on its own if it had to. It lasts and wears off times differ per person and how often they push the little button to administer more medication. Every Dr and hospital are different some take it out if your going to push because they want you to feel the pressure, some dont mind if the partner is in the room as long as they stay out of the way of the anesthesiologist, but then some have policy that no one but the nurse and anesthesiologist can be in the room with the woman. Mine didnt work with any of my labors and deliveries, many women have epidurals and they work great, many women have them and they dont work at all. just know you did with out before and you were fine, you can do it, but I hope you are able to get a pain med if you want one, they do work wonderfully when they work, good luck~ Answered by Wilfredo Belknap 2 years ago.

Check out www.wikipedia.com and search for Pethidine. Find the basic ingredients for synthesis then using basic knowledge of synthetic organic chemistry, make some demerol. Oh and by the way, it is illegal to make unless you are a licensed pharmaceutical company. Its not as easy as making crack or meth...so stick to those. And for future reference, please don't ask questions on how to make drugs. Answered by Isidro Alicer 2 years ago.


Question about the drug demerol/pethidine..?
True John. But at least we know the heroin is being supplied on the black market, not administered illegally by rogue doctors. Asked by Jeanetta Holthaus 2 years ago.

Demerol (pethidine/meperidine) is a synthetic opiate analgesic and it is a schedule II drug in The United States, Schedule I in Canada, and Class A in The UK. In just about any country Demerol would fall under the highest levels of control. But it is prescribed for patients all of the time. It is very commonly given (in hospital) for migraine that does not respond to other drugs. Some people doctor shop and get reasonable amount of narcotics from each doctor- but from 4 or 5 doctors and end up with a large amount of drugs. And there are very shady doctors out there who prescribe drugs as if it were nothing, sometimes because they are incompetent other times to satisfy a paying customer. And personal doctors are a bit more likely to doll out whatever the patient "needs." In many cases where The DEA revokes a doctors DEA number (required to give controlled substances) the doctor was giving out drugs in extreme excess. I know of one case where one doctor wrote 90 prescriptions for OxyContin to one person over 6 months or so. Also if you have a good relationship with your doctor and you have known each other for years and years then a doctor would probably be more amiable to prescribe any drug, but only to a point. Most doctors will not prescribe IV Demerol outside of a hospital/hospice. IV opiates are really only needed in emergency situations (morphine for heart attack) or for cancer, AIDS, and other conditions that can cause extreme pain. Answered by Neta Capozzoli 2 years ago.

I'm not in California but all the states must follow the Federal laws governing narcotics. Demerol is strictly controlled but as in many celebrity situations there are doctors willing to bend the law to be near the limelight.Demerol is rarely used for pain & is given in tablet form by prescription only if other narcotics either don't work or a patient is allergic to codeine, oxycodone, and morphine (doctors better document this too for the Feds will yank their license if they find no records being kept...this applies in all narcotic prescriptions).Demerol is commonly used in hospitals for surgical patients & properly used short term only.It's not good for chronic use. In Hospice we almost never use Demerol for Morphine works much better for chronic pain as does Fentanyl. I've worked as a nurse for over 40 years and anytime someone asked for Demerol...they never got it and were looked on with suspicion for we knew they were addicts.I can truthfully say I've only seen prescriptions for Demerol for anyone outside the hospital setting maybe 6 times, mostly in tablet form & only 12 pills (dentists mostly post extraction).Celebrity Demerol isn't proper medicine. Answered by Edda Selic 2 years ago.

It's also strictly controlled in the US. If rumors are even vaguely close to true, then it wouldn't be surprising for MJ's physician to have hired an attorney at least in part because of a risk of losing his narcotic licensure, and perhaps even his license to practice medicine. On the other hand, there is no drug that can't be had by the wealthy or the determined. Certainly even heroin addiction is far from unknown in the UK! Answered by Edwardo Standors 2 years ago.

I had an epidural last year and I was numb for a few hours after having my daughter. I had to have the nurses help me walk to the bathroom to take a bath. I dont think everyone is numb for hours I think it depends how long you have the epidural on for. I was in labor for 17 hours and I had the epidural for about 14 hours or so. Dont worry about it, after you give birth you may feel too tired to even get up so dont worry too much. You'll be fine! Answered by Foster Hissom 2 years ago.

Lestermount Answered by Bee Bateson 2 years ago.


If Demerol is not supposed to used in treating long term pain management, how long would it be used for?
If Demerol is not safe for long term treatment of pain because of toxic buildup what would be the generally accepted period of time that it is safe to use? Would it be days, weeks, etc? The Michael Jackson case has sparked my curiosity. Thank you. Asked by Alleen Eppard 2 years ago.

Demerol is used for the treatment of chronic pain and acute pain. Many doctors prefer Demerol to other opiate analgesics due to some of its unique properties (but it falls more out of favour every year). However, some of its unique properties involving the reuptake of monoamine neurotransmitters (dopamine, serotonin, norepinephrine) and its almost cocaine like stimulation and anesthetic ability (cocaine is a local anesthetic) plus its very fast action makes it more addictive than other IV drugs, it has multiple major drug interactions, does not fully respond to opiate antagonists like Naloxone (for use in OD situations as an antidote), and it is actually toxic (a neurotoxin). One things opiates, especially naturally occurring and semisynthetic opiates, are known for are being "clean" drugs. This means that opiates like morphine do not interact with many neurotransmitters and receptors. So opiates have targeted action. Demerol acts with all sorts of neurotransmitters and has active metabolites that can damage the body. It is almost like morphine and cocaine mixed together hitting the brain in seconds after given IV. Thus it is far more addictive and has the potential for many problems (including cardiac). But it is not exactly a bad drug. Short term use is normally safe and people with certain medical conditions or who do not respond well to morphine and related drugs might use Demerol. It is available in tablet forms that people can take at home for pain. And it is very rare for IV Demerol to be needed except in hospital or home hospice. I can't imagine Jackson was in enough pain that he required daily shots of IV Demerol. Oral pain medication is typically effective in all but extreme situations. Answered by Vi Burdin 2 years ago.

Toxic buildup is not the problem, addiction is. Demerol is a derivative of opium, similar to morphine. It is very effective as a pain killer, especially after a surgical procedure. Thus, it is almost ideal for short term use. For reasons that are not completely clear, some persons are more prone to addiction than others. Giving Demerol to these persons over an extended period of time is inadvisable. Many physicians are not astute as to the warning signs. Asking for repeated prescription refills is one huge red flag. Answered by Marquetta Bowersox 2 years ago.

It is physically addictive and your body begins to build a tolerance to opiates. Over a long period of time the patient will need larger and larger doses of Vicodin to relieve their pain. Answered by Deandra Laplante 2 years ago.


Does anyone know if there is a doctor that uses Demerol for pain?
I have a lot of headaches for over 40 year now. During my fifteenth year of these headaches I was sitting at work when my head thought it was going to blow apart, I have never in my life had a pain that felt like my brains were going to explode outward, I called my Dad and said :You've got to take me to the... Asked by Carmelina Viteo 2 years ago.

I have a lot of headaches for over 40 year now. During my fifteenth year of these headaches I was sitting at work when my head thought it was going to blow apart, I have never in my life had a pain that felt like my brains were going to explode outward, I called my Dad and said :You've got to take me to the hospital ASAP as I think I am about to die,,,,and I really felt like i was going to die. I was saying my last prayers and I was crying eyes out over all the missed opportunity to do the things I should have done. Then I got to the ER and the doctor gave me a shot of 125 mg Demerol. My dad was in the room with me and I was complaining as to how much my head was still hurt,,,,,ing,,,,did I say HURT ng..........OMG .......it doesn.t hurt anymore...........I can't believe WHAT WAS THAT STUFF????? They told me it was called Demerol. This medicine took my 5 day headache away in 15 minutes. I want to know who has been hiding this stuff all this time. The ER's I go to tell they are using Dilaudid now and phasing out Demerol. That is sad, myself and many , many others believe that Demerol is the best headache medicine out there. If anyone knows which doctor would be willing to administer it, I would very very greatfull and thank you.Thank You and Thank You Answered by Pei Gainer 2 years ago.

Demerol is still used although its use is in decline. Some hospitals have phased it out and it is not commonly prescribed out patient. Unlike other full opioid agonists (eg methadone, morphine, hydromorphone, oxymorphone) Demerol has a maximum dose, it is significantly neurotoxic and cardiotoxic in even modest doses or when taken too long, it tends to be more abused than other opioids (likely because it has opioid effects and it also has some pharmacological properties of cocaine). Demerol can only be taken for about two weeks at a time whereas most other opioids don't have a limit. I hear similar things from patients all the time. People with extremely severe headaches tend to respond extremely well to Demerol. In addition some consider Demerol to be the best drug to provide the most rapid and effective analgesia. Also hospitals try to avoid using opioids when a patients presents with a headache. However the reality is that opioids are extremely effective treatment to stop the pain once it starts and about 68% of the time opioids are used. People who only have occasional headaches are often prescribed opioids and/or barbiturates because they work so well. If you only have an occasional headache many doctors would likely be willing to prescribe a small number of Demerol tablets (in Canada there are 50 mg tabs and in America I believe there are 50 and 100 mg tabs). And doctors certainly do not administer IV Demerol except in hospital. You are just going to have to see a doctor about treatment. Other medications are something to consider. I will tell you that asking for Demerol and refusing to consider other treatment will make you look like a drug seeker. Answered by Charisse Weisbrod 2 years ago.

Demerol Uses Answered by Mackenzie Consuegra 2 years ago.

Yes, they are phasing out Demerol permanently because it breaks down in the body into toxic substances. For headaches now they use a mix of Toradol (NSAID), anti nausea med (usually Zofran) and sometimes IV Benedryl. Does the same thing as Demerol for 1/2 the price, AND there are no opiates in any of them, so we can discharge patients faster. Answered by Belle Darey 2 years ago.

The prescription of meperidine or demerol is for moderate to severe pain. If your pain is really really so bad that you can feel your head bursting open, the pain is even worse than getting your head smashed by a beer bottle you should go to your doctor again to explain the situation. Demerol has too many complication when taken. Answered by Andera Colasanti 2 years ago.


How is Demerol administered--IV, IM, or both. About how much time before side effects would become apparent?
Also, what would be perhaps the initial side effects? Thank you Asked by Carlota Linsin 2 years ago.

Demerol can be given in pill form as well as IM or IV but usually the prescriptions are only given to patients in pill form for obvious reasons since shots & IV use are usually by medical personnel. With pill form usually the effect is felt in 30 minutes after pill dissolves.IV dose is felt within 1-2 minutes.IM dose is usually felt in 15-20 minutes (unless patient has other drugs in the system which may cause it to be earlier).Patients normally start to feel relaxed then say the pain starts to ease off.They often complain of being light headed & sleepy. Literature says the pain is relieved for 4 hours but in my experience patients start to complain of pain again in 3 hours.Demerol is really not a good drug for chronic pain management. Morphine lasts longer & easier to use in terminal patients.Demerol should only be used for short term patients & also not those mixing other opiates. Answered by Allyson Hignite 2 years ago.

This Site Might Help You. RE: How is Demerol administered--IV, IM, or both. About how much time before side effects would become apparent? Also, what would be perhaps the initial side effects? Thank you Answered by Regenia Replenski 2 years ago.

This I happen to know. Demerol can be administered either way. When administered IV, the drug takes effect immediately [depending on the strength] IM, about 15 min. 50mg to 100mg are the preferred dosage. Side effects include foggy brain, thick tongue and not being able to say "no", sexually speaking. I know this first hand. Enjoy the feeling. Answered by Toby Reado 2 years ago.


What does Demerol do? Is it as effective as an epidural?
Asked by Merri Tasch 2 years ago.

Demerol is a narcotic that will take the edge off of your pains and makes you feel a little elevated if you will!! It doesn't last that long, maybe an hour or 2 if your lucky and is best used towards the end of your labor as you are only allowed so many doses throughout your labor!! It is not nearly effective as an epidural because with the Demerol, you still feel your contractions, it just takes the edge off of it where as with the epidural, you are completely numb and can't feel anything until they lower your epidural medication!! Answered by Marcy Burlington 2 years ago.

demerol is a shot that is givenin the arm or hip sometimes given in an IV that is used to dull the pain and relax the mom so she can cope with the pain of contractions it's usually given every 2 to 4 hours.. it makes you feel drowsy it also sometimes causes nauses vomiting and a drop in blood pressure. and it sometimes does effect the babys breathing patterns and ability to suck right after delivery but the side effects wear off.. and epideral is administrated by a large needle into the epideral space of the spine. the needle will insert a small catheter into the space in which the medication will be released... this will numb your lower half of your body.. they can set the drip so you can feel some so your not completely numb to the experience.. from what i've read the only effect this can have on the baby is slowing the heart rate down on some... Answered by Della Cianchetti 2 years ago.

No, all demerol does is make you feel more at ease..kinda high if you will. Epidural is a shot given to you in your back and it numbs your lower body. Answered by Rose Flaugher 2 years ago.

No its not as effective as an epidural, demerol makes you groggy and less aware of the situation . epidural makes you numb but doesn't mess iwth your mind state. Answered by Marci Gaton 2 years ago.

demerol is nothing like the epidural, opt for the epidural so u can at least be awake when you deliver. Answered by Vilma Boser 2 years ago.

It makes you drowsy and unaware the epidural numbs from the waist down and doesnt make you drowsy in both births I had epidurals I waouldnt suggest the demoral but everyone is different Answered by Caryl Annino 2 years ago.

ive had demerol once, non pregnancy related...and im terribly allergic. Apparently. It gave me a really horrible rash, i had to get a shot to make it go away. it was all kinds of bad for me. Answered by Demetria Cefaratti 2 years ago.


How is Demerol made?
Asked by Paz Maack 2 years ago.

Isonicotinic Acid Methochloride. To a slurry of 246 g of isonicotinic acid in 3.2 liters of methanol and 300 ml of water containing 88 g of sodium hydroxide has 355 g of methyl iodide added to it. Note: Isonicotinic acid can be replaced with nicotinic acid, thus producing B-pethidine, instead of demerol. There is very little difference in potency between these two drugs and the formula does not change (just use an equimolar amount of nicotinic acid), so you may use either acid. Stir and reflux the above mixture for 60 hours, then remove the methanol with vacuo. Use sodium thiosulfate to reduce iodine to iodide and add water to give a volume of 1.5 liters. Use hydrochloric acid (concd) to get a ph of 2.0. Place a slurry of Amberlite IRA-400 (6.30 equivalents) in a glass tube 10 cm in diameter and 100 cm high. The resin is washed with 20 x 1. of 5% hydrochloric acid followed with 40 x 1. of distilled water. The yellow aqueous solution is passed through the column and the effluent, which had better be iodine free, is collected at a rate of flow of 50 ml per min. Three and one half liters of effluent is coned and the residue is dried and extracted with acetic acid. Xylene is added to the hot acetic acid solution, then cooled, and saturated with dry hydrogen chloride to give 336 g of crude product. Recrystallize from acetic acid to purify. 1-Methyl-4-carboxypiperidine Hydrochloride. Isonicotinic acid methochloride is quantitively reduced in a high pressure reaction vessel in the presence of platinum oxide in methanol at 1,000 psi, mp: 231-232°. 1-Methyl-4-chloro-4-benzoylpiperidine Hydrochloride. Chlorine gas is slowly passed (bubbled) into a solution of 48 g of the above product in 500 ml of glacial acetic acid for 8 hours at 70°. The volume is evaporated to 150 ml and 1 1iter of dry ether is added. The resulting white powder is recrystallized from chloroform, yielding 45 g of the hydrochloric salt, mp: 181° to 182°. This is then recrystallized from Skelly A, mp: 48-49°C. Rearrangement of 1-Mehtyl-4-chloro-4-benzoylpiperidine. Add 50 ml of xylene (containing 3.5 g of the above product) to a stirred refluxing solution containing 200 ml dry xylene and 18 g of finely powdered, dried sodium NaOH. Stir while refluxing for 30 min, then cool, extract with 25 ml portion of water until the ph of the extracts reaches neutrality (approximately). The combined water extracts are washed with three 25 ml portions of ether and adjusted to 8 ph with hydrochloric acid. The aqueous solution is concentrated to 50 ml (by evaporation in vacuo), filtered, and acidified to 6.5 with hydrochloric acid. The solution is cooled and the crystals are washed with water, acetone, ether, and then dried. Recrystallize from water to get fine, white needles of 1-methyl-4-phenyl-4-carboxy- piperidine. Yield: 0.8 g, mp: 309-310°. This product is then dissolved in ether and treated by passing dry hydrogen chloride through this solution and recrystallizing the resulting salt from acetic acid-benzene. Take the above hydrochloride salt and reflux it in ethanolic hydrogen chloride to get Demerol or analog. Now, you need to know that if you get it wrong, you may end up with a drug that causes irreversible Parkinsonism. If you use too much Demerol, there is a metabolite that will build up and knock off your kidneys. BTW, I left out a step. It's really not something an amateur can cook up. Answered by Lanora Austill 2 years ago.

What Is Demerol Made Of Answered by Lynsey Engles 2 years ago.

Active Ingredient: Meperidine Hydrochloride Inactive Ingredients Tablets: Calcium Sulfate, Dibasic Calcium phosphate, Starch, Stearic Acid, Talc. Syrup: Benzoic Acid, Flavor, Liquid Glucose, Purified Water, Saccharin Sodium. Answered by Daren Vieau 2 years ago.

You dont feel the spinal cathedar once the med takes effect. It can only make labor go longer if there is a lot of meds and the woman cant feel anything, like no pressure. Doesnt matter the baby will come your body will push it out on its own if it had to. It lasts and wears off times differ per person and how often they push the little button to administer more medication. Every Dr and hospital are different some take it out if your going to push because they want you to feel the pressure, some dont mind if the partner is in the room as long as they stay out of the way of the anesthesiologist, but then some have policy that no one but the nurse and anesthesiologist can be in the room with the woman. Mine didnt work with any of my labors and deliveries, many women have epidurals and they work great, many women have them and they dont work at all. just know you did with out before and you were fine, you can do it, but I hope you are able to get a pain med if you want one, they do work wonderfully when they work, good luck~ Answered by Bethanie Hammersley 2 years ago.

Check out www.wikipedia.com and search for Pethidine. Find the basic ingredients for synthesis then using basic knowledge of synthetic organic chemistry, make some demerol. Oh and by the way, it is illegal to make unless you are a licensed pharmaceutical company. Its not as easy as making crack or meth...so stick to those. And for future reference, please don't ask questions on how to make drugs. Answered by Isa Lee 2 years ago.


Question about the drug demerol/pethidine..?
True John. But at least we know the heroin is being supplied on the black market, not administered illegally by rogue doctors. Asked by Pamala Yiu 2 years ago.

Demerol (pethidine/meperidine) is a synthetic opiate analgesic and it is a schedule II drug in The United States, Schedule I in Canada, and Class A in The UK. In just about any country Demerol would fall under the highest levels of control. But it is prescribed for patients all of the time. It is very commonly given (in hospital) for migraine that does not respond to other drugs. Some people doctor shop and get reasonable amount of narcotics from each doctor- but from 4 or 5 doctors and end up with a large amount of drugs. And there are very shady doctors out there who prescribe drugs as if it were nothing, sometimes because they are incompetent other times to satisfy a paying customer. And personal doctors are a bit more likely to doll out whatever the patient "needs." In many cases where The DEA revokes a doctors DEA number (required to give controlled substances) the doctor was giving out drugs in extreme excess. I know of one case where one doctor wrote 90 prescriptions for OxyContin to one person over 6 months or so. Also if you have a good relationship with your doctor and you have known each other for years and years then a doctor would probably be more amiable to prescribe any drug, but only to a point. Most doctors will not prescribe IV Demerol outside of a hospital/hospice. IV opiates are really only needed in emergency situations (morphine for heart attack) or for cancer, AIDS, and other conditions that can cause extreme pain. Answered by Delcie Pahnke 2 years ago.

I'm not in California but all the states must follow the Federal laws governing narcotics. Demerol is strictly controlled but as in many celebrity situations there are doctors willing to bend the law to be near the limelight.Demerol is rarely used for pain & is given in tablet form by prescription only if other narcotics either don't work or a patient is allergic to codeine, oxycodone, and morphine (doctors better document this too for the Feds will yank their license if they find no records being kept...this applies in all narcotic prescriptions).Demerol is commonly used in hospitals for surgical patients & properly used short term only.It's not good for chronic use. In Hospice we almost never use Demerol for Morphine works much better for chronic pain as does Fentanyl. I've worked as a nurse for over 40 years and anytime someone asked for Demerol...they never got it and were looked on with suspicion for we knew they were addicts.I can truthfully say I've only seen prescriptions for Demerol for anyone outside the hospital setting maybe 6 times, mostly in tablet form & only 12 pills (dentists mostly post extraction).Celebrity Demerol isn't proper medicine. Answered by Sherry Beasly 2 years ago.

It's also strictly controlled in the US. If rumors are even vaguely close to true, then it wouldn't be surprising for MJ's physician to have hired an attorney at least in part because of a risk of losing his narcotic licensure, and perhaps even his license to practice medicine. On the other hand, there is no drug that can't be had by the wealthy or the determined. Certainly even heroin addiction is far from unknown in the UK! Answered by Rima Novencido 2 years ago.

I had an epidural last year and I was numb for a few hours after having my daughter. I had to have the nurses help me walk to the bathroom to take a bath. I dont think everyone is numb for hours I think it depends how long you have the epidural on for. I was in labor for 17 hours and I had the epidural for about 14 hours or so. Dont worry about it, after you give birth you may feel too tired to even get up so dont worry too much. You'll be fine! Answered by Ammie Southward 2 years ago.

Lestermount Answered by Hermina Hatake 2 years ago.


If Demerol is not supposed to used in treating long term pain management, how long would it be used for?
If Demerol is not safe for long term treatment of pain because of toxic buildup what would be the generally accepted period of time that it is safe to use? Would it be days, weeks, etc? The Michael Jackson case has sparked my curiosity. Thank you. Asked by Roselyn Juckett 2 years ago.

Demerol is used for the treatment of chronic pain and acute pain. Many doctors prefer Demerol to other opiate analgesics due to some of its unique properties (but it falls more out of favour every year). However, some of its unique properties involving the reuptake of monoamine neurotransmitters (dopamine, serotonin, norepinephrine) and its almost cocaine like stimulation and anesthetic ability (cocaine is a local anesthetic) plus its very fast action makes it more addictive than other IV drugs, it has multiple major drug interactions, does not fully respond to opiate antagonists like Naloxone (for use in OD situations as an antidote), and it is actually toxic (a neurotoxin). One things opiates, especially naturally occurring and semisynthetic opiates, are known for are being "clean" drugs. This means that opiates like morphine do not interact with many neurotransmitters and receptors. So opiates have targeted action. Demerol acts with all sorts of neurotransmitters and has active metabolites that can damage the body. It is almost like morphine and cocaine mixed together hitting the brain in seconds after given IV. Thus it is far more addictive and has the potential for many problems (including cardiac). But it is not exactly a bad drug. Short term use is normally safe and people with certain medical conditions or who do not respond well to morphine and related drugs might use Demerol. It is available in tablet forms that people can take at home for pain. And it is very rare for IV Demerol to be needed except in hospital or home hospice. I can't imagine Jackson was in enough pain that he required daily shots of IV Demerol. Oral pain medication is typically effective in all but extreme situations. Answered by Doyle Daft 2 years ago.

Toxic buildup is not the problem, addiction is. Demerol is a derivative of opium, similar to morphine. It is very effective as a pain killer, especially after a surgical procedure. Thus, it is almost ideal for short term use. For reasons that are not completely clear, some persons are more prone to addiction than others. Giving Demerol to these persons over an extended period of time is inadvisable. Many physicians are not astute as to the warning signs. Asking for repeated prescription refills is one huge red flag. Answered by Maryrose Fillion 2 years ago.

It is physically addictive and your body begins to build a tolerance to opiates. Over a long period of time the patient will need larger and larger doses of Vicodin to relieve their pain. Answered by Jacinto Perreault 2 years ago.


Does anyone know if there is a doctor that uses Demerol for pain?
I have a lot of headaches for over 40 year now. During my fifteenth year of these headaches I was sitting at work when my head thought it was going to blow apart, I have never in my life had a pain that felt like my brains were going to explode outward, I called my Dad and said :You've got to take me to the... Asked by Johnson Resureccion 2 years ago.

I have a lot of headaches for over 40 year now. During my fifteenth year of these headaches I was sitting at work when my head thought it was going to blow apart, I have never in my life had a pain that felt like my brains were going to explode outward, I called my Dad and said :You've got to take me to the hospital ASAP as I think I am about to die,,,,and I really felt like i was going to die. I was saying my last prayers and I was crying eyes out over all the missed opportunity to do the things I should have done. Then I got to the ER and the doctor gave me a shot of 125 mg Demerol. My dad was in the room with me and I was complaining as to how much my head was still hurt,,,,,ing,,,,did I say HURT ng..........OMG .......it doesn.t hurt anymore...........I can't believe WHAT WAS THAT STUFF????? They told me it was called Demerol. This medicine took my 5 day headache away in 15 minutes. I want to know who has been hiding this stuff all this time. The ER's I go to tell they are using Dilaudid now and phasing out Demerol. That is sad, myself and many , many others believe that Demerol is the best headache medicine out there. If anyone knows which doctor would be willing to administer it, I would very very greatfull and thank you.Thank You and Thank You Answered by Stephany Rakich 2 years ago.

Demerol is still used although its use is in decline. Some hospitals have phased it out and it is not commonly prescribed out patient. Unlike other full opioid agonists (eg methadone, morphine, hydromorphone, oxymorphone) Demerol has a maximum dose, it is significantly neurotoxic and cardiotoxic in even modest doses or when taken too long, it tends to be more abused than other opioids (likely because it has opioid effects and it also has some pharmacological properties of cocaine). Demerol can only be taken for about two weeks at a time whereas most other opioids don't have a limit. I hear similar things from patients all the time. People with extremely severe headaches tend to respond extremely well to Demerol. In addition some consider Demerol to be the best drug to provide the most rapid and effective analgesia. Also hospitals try to avoid using opioids when a patients presents with a headache. However the reality is that opioids are extremely effective treatment to stop the pain once it starts and about 68% of the time opioids are used. People who only have occasional headaches are often prescribed opioids and/or barbiturates because they work so well. If you only have an occasional headache many doctors would likely be willing to prescribe a small number of Demerol tablets (in Canada there are 50 mg tabs and in America I believe there are 50 and 100 mg tabs). And doctors certainly do not administer IV Demerol except in hospital. You are just going to have to see a doctor about treatment. Other medications are something to consider. I will tell you that asking for Demerol and refusing to consider other treatment will make you look like a drug seeker. Answered by Jess Hedman 2 years ago.

Demerol Uses Answered by Hazel Schenck 2 years ago.

Yes, they are phasing out Demerol permanently because it breaks down in the body into toxic substances. For headaches now they use a mix of Toradol (NSAID), anti nausea med (usually Zofran) and sometimes IV Benedryl. Does the same thing as Demerol for 1/2 the price, AND there are no opiates in any of them, so we can discharge patients faster. Answered by Russ Meltzer 2 years ago.

The prescription of meperidine or demerol is for moderate to severe pain. If your pain is really really so bad that you can feel your head bursting open, the pain is even worse than getting your head smashed by a beer bottle you should go to your doctor again to explain the situation. Demerol has too many complication when taken. Answered by Rosalina Birks 2 years ago.


How is Demerol administered--IV, IM, or both. About how much time before side effects would become apparent?
Also, what would be perhaps the initial side effects? Thank you Asked by Filomena Mussman 2 years ago.

Demerol can be given in pill form as well as IM or IV but usually the prescriptions are only given to patients in pill form for obvious reasons since shots & IV use are usually by medical personnel. With pill form usually the effect is felt in 30 minutes after pill dissolves.IV dose is felt within 1-2 minutes.IM dose is usually felt in 15-20 minutes (unless patient has other drugs in the system which may cause it to be earlier).Patients normally start to feel relaxed then say the pain starts to ease off.They often complain of being light headed & sleepy. Literature says the pain is relieved for 4 hours but in my experience patients start to complain of pain again in 3 hours.Demerol is really not a good drug for chronic pain management. Morphine lasts longer & easier to use in terminal patients.Demerol should only be used for short term patients & also not those mixing other opiates. Answered by Claire Thivierge 2 years ago.

This Site Might Help You. RE: How is Demerol administered--IV, IM, or both. About how much time before side effects would become apparent? Also, what would be perhaps the initial side effects? Thank you Answered by Lang Knoy 2 years ago.

This I happen to know. Demerol can be administered either way. When administered IV, the drug takes effect immediately [depending on the strength] IM, about 15 min. 50mg to 100mg are the preferred dosage. Side effects include foggy brain, thick tongue and not being able to say "no", sexually speaking. I know this first hand. Enjoy the feeling. Answered by Oscar Hansis 2 years ago.


What does Demerol do? Is it as effective as an epidural?
Asked by Lacie Bayird 2 years ago.

Demerol is a narcotic that will take the edge off of your pains and makes you feel a little elevated if you will!! It doesn't last that long, maybe an hour or 2 if your lucky and is best used towards the end of your labor as you are only allowed so many doses throughout your labor!! It is not nearly effective as an epidural because with the Demerol, you still feel your contractions, it just takes the edge off of it where as with the epidural, you are completely numb and can't feel anything until they lower your epidural medication!! Answered by Joe Carreras 2 years ago.

demerol is a shot that is givenin the arm or hip sometimes given in an IV that is used to dull the pain and relax the mom so she can cope with the pain of contractions it's usually given every 2 to 4 hours.. it makes you feel drowsy it also sometimes causes nauses vomiting and a drop in blood pressure. and it sometimes does effect the babys breathing patterns and ability to suck right after delivery but the side effects wear off.. and epideral is administrated by a large needle into the epideral space of the spine. the needle will insert a small catheter into the space in which the medication will be released... this will numb your lower half of your body.. they can set the drip so you can feel some so your not completely numb to the experience.. from what i've read the only effect this can have on the baby is slowing the heart rate down on some... Answered by Marget Voelz 2 years ago.

No, all demerol does is make you feel more at ease..kinda high if you will. Epidural is a shot given to you in your back and it numbs your lower body. Answered by Junior Hoeger 2 years ago.

No its not as effective as an epidural, demerol makes you groggy and less aware of the situation . epidural makes you numb but doesn't mess iwth your mind state. Answered by Shantae Maurus 2 years ago.

demerol is nothing like the epidural, opt for the epidural so u can at least be awake when you deliver. Answered by Kristie Brehony 2 years ago.

It makes you drowsy and unaware the epidural numbs from the waist down and doesnt make you drowsy in both births I had epidurals I waouldnt suggest the demoral but everyone is different Answered by Laverna Speiden 2 years ago.

ive had demerol once, non pregnancy related...and im terribly allergic. Apparently. It gave me a really horrible rash, i had to get a shot to make it go away. it was all kinds of bad for me. Answered by Ethan Clayman 2 years ago.


How is Demerol made?
Asked by Wava Vongsamphanh 2 years ago.

Isonicotinic Acid Methochloride. To a slurry of 246 g of isonicotinic acid in 3.2 liters of methanol and 300 ml of water containing 88 g of sodium hydroxide has 355 g of methyl iodide added to it. Note: Isonicotinic acid can be replaced with nicotinic acid, thus producing B-pethidine, instead of demerol. There is very little difference in potency between these two drugs and the formula does not change (just use an equimolar amount of nicotinic acid), so you may use either acid. Stir and reflux the above mixture for 60 hours, then remove the methanol with vacuo. Use sodium thiosulfate to reduce iodine to iodide and add water to give a volume of 1.5 liters. Use hydrochloric acid (concd) to get a ph of 2.0. Place a slurry of Amberlite IRA-400 (6.30 equivalents) in a glass tube 10 cm in diameter and 100 cm high. The resin is washed with 20 x 1. of 5% hydrochloric acid followed with 40 x 1. of distilled water. The yellow aqueous solution is passed through the column and the effluent, which had better be iodine free, is collected at a rate of flow of 50 ml per min. Three and one half liters of effluent is coned and the residue is dried and extracted with acetic acid. Xylene is added to the hot acetic acid solution, then cooled, and saturated with dry hydrogen chloride to give 336 g of crude product. Recrystallize from acetic acid to purify. 1-Methyl-4-carboxypiperidine Hydrochloride. Isonicotinic acid methochloride is quantitively reduced in a high pressure reaction vessel in the presence of platinum oxide in methanol at 1,000 psi, mp: 231-232°. 1-Methyl-4-chloro-4-benzoylpiperidine Hydrochloride. Chlorine gas is slowly passed (bubbled) into a solution of 48 g of the above product in 500 ml of glacial acetic acid for 8 hours at 70°. The volume is evaporated to 150 ml and 1 1iter of dry ether is added. The resulting white powder is recrystallized from chloroform, yielding 45 g of the hydrochloric salt, mp: 181° to 182°. This is then recrystallized from Skelly A, mp: 48-49°C. Rearrangement of 1-Mehtyl-4-chloro-4-benzoylpiperidine. Add 50 ml of xylene (containing 3.5 g of the above product) to a stirred refluxing solution containing 200 ml dry xylene and 18 g of finely powdered, dried sodium NaOH. Stir while refluxing for 30 min, then cool, extract with 25 ml portion of water until the ph of the extracts reaches neutrality (approximately). The combined water extracts are washed with three 25 ml portions of ether and adjusted to 8 ph with hydrochloric acid. The aqueous solution is concentrated to 50 ml (by evaporation in vacuo), filtered, and acidified to 6.5 with hydrochloric acid. The solution is cooled and the crystals are washed with water, acetone, ether, and then dried. Recrystallize from water to get fine, white needles of 1-methyl-4-phenyl-4-carboxy- piperidine. Yield: 0.8 g, mp: 309-310°. This product is then dissolved in ether and treated by passing dry hydrogen chloride through this solution and recrystallizing the resulting salt from acetic acid-benzene. Take the above hydrochloride salt and reflux it in ethanolic hydrogen chloride to get Demerol or analog. Now, you need to know that if you get it wrong, you may end up with a drug that causes irreversible Parkinsonism. If you use too much Demerol, there is a metabolite that will build up and knock off your kidneys. BTW, I left out a step. It's really not something an amateur can cook up. Answered by Fermina Thelemaque 2 years ago.

What Is Demerol Made Of Answered by Lorrine Cutt 2 years ago.

Active Ingredient: Meperidine Hydrochloride Inactive Ingredients Tablets: Calcium Sulfate, Dibasic Calcium phosphate, Starch, Stearic Acid, Talc. Syrup: Benzoic Acid, Flavor, Liquid Glucose, Purified Water, Saccharin Sodium. Answered by Kati Raabe 2 years ago.

You dont feel the spinal cathedar once the med takes effect. It can only make labor go longer if there is a lot of meds and the woman cant feel anything, like no pressure. Doesnt matter the baby will come your body will push it out on its own if it had to. It lasts and wears off times differ per person and how often they push the little button to administer more medication. Every Dr and hospital are different some take it out if your going to push because they want you to feel the pressure, some dont mind if the partner is in the room as long as they stay out of the way of the anesthesiologist, but then some have policy that no one but the nurse and anesthesiologist can be in the room with the woman. Mine didnt work with any of my labors and deliveries, many women have epidurals and they work great, many women have them and they dont work at all. just know you did with out before and you were fine, you can do it, but I hope you are able to get a pain med if you want one, they do work wonderfully when they work, good luck~ Answered by Teodoro Danison 2 years ago.

Check out www.wikipedia.com and search for Pethidine. Find the basic ingredients for synthesis then using basic knowledge of synthetic organic chemistry, make some demerol. Oh and by the way, it is illegal to make unless you are a licensed pharmaceutical company. Its not as easy as making crack or meth...so stick to those. And for future reference, please don't ask questions on how to make drugs. Answered by Elidia Aliaga 2 years ago.


Question about the drug demerol/pethidine..?
True John. But at least we know the heroin is being supplied on the black market, not administered illegally by rogue doctors. Asked by Bill Guill 2 years ago.

Demerol (pethidine/meperidine) is a synthetic opiate analgesic and it is a schedule II drug in The United States, Schedule I in Canada, and Class A in The UK. In just about any country Demerol would fall under the highest levels of control. But it is prescribed for patients all of the time. It is very commonly given (in hospital) for migraine that does not respond to other drugs. Some people doctor shop and get reasonable amount of narcotics from each doctor- but from 4 or 5 doctors and end up with a large amount of drugs. And there are very shady doctors out there who prescribe drugs as if it were nothing, sometimes because they are incompetent other times to satisfy a paying customer. And personal doctors are a bit more likely to doll out whatever the patient "needs." In many cases where The DEA revokes a doctors DEA number (required to give controlled substances) the doctor was giving out drugs in extreme excess. I know of one case where one doctor wrote 90 prescriptions for OxyContin to one person over 6 months or so. Also if you have a good relationship with your doctor and you have known each other for years and years then a doctor would probably be more amiable to prescribe any drug, but only to a point. Most doctors will not prescribe IV Demerol outside of a hospital/hospice. IV opiates are really only needed in emergency situations (morphine for heart attack) or for cancer, AIDS, and other conditions that can cause extreme pain. Answered by Ross Menezes 2 years ago.

I'm not in California but all the states must follow the Federal laws governing narcotics. Demerol is strictly controlled but as in many celebrity situations there are doctors willing to bend the law to be near the limelight.Demerol is rarely used for pain & is given in tablet form by prescription only if other narcotics either don't work or a patient is allergic to codeine, oxycodone, and morphine (doctors better document this too for the Feds will yank their license if they find no records being kept...this applies in all narcotic prescriptions).Demerol is commonly used in hospitals for surgical patients & properly used short term only.It's not good for chronic use. In Hospice we almost never use Demerol for Morphine works much better for chronic pain as does Fentanyl. I've worked as a nurse for over 40 years and anytime someone asked for Demerol...they never got it and were looked on with suspicion for we knew they were addicts.I can truthfully say I've only seen prescriptions for Demerol for anyone outside the hospital setting maybe 6 times, mostly in tablet form & only 12 pills (dentists mostly post extraction).Celebrity Demerol isn't proper medicine. Answered by Loria Baltrip 2 years ago.

It's also strictly controlled in the US. If rumors are even vaguely close to true, then it wouldn't be surprising for MJ's physician to have hired an attorney at least in part because of a risk of losing his narcotic licensure, and perhaps even his license to practice medicine. On the other hand, there is no drug that can't be had by the wealthy or the determined. Certainly even heroin addiction is far from unknown in the UK! Answered by Raylene Arroyd 2 years ago.

I had an epidural last year and I was numb for a few hours after having my daughter. I had to have the nurses help me walk to the bathroom to take a bath. I dont think everyone is numb for hours I think it depends how long you have the epidural on for. I was in labor for 17 hours and I had the epidural for about 14 hours or so. Dont worry about it, after you give birth you may feel too tired to even get up so dont worry too much. You'll be fine! Answered by Laci Karmely 2 years ago.

Lestermount Answered by Hui Ruel 2 years ago.


If Demerol is not supposed to used in treating long term pain management, how long would it be used for?
If Demerol is not safe for long term treatment of pain because of toxic buildup what would be the generally accepted period of time that it is safe to use? Would it be days, weeks, etc? The Michael Jackson case has sparked my curiosity. Thank you. Asked by Lorriane Albery 2 years ago.

Demerol is used for the treatment of chronic pain and acute pain. Many doctors prefer Demerol to other opiate analgesics due to some of its unique properties (but it falls more out of favour every year). However, some of its unique properties involving the reuptake of monoamine neurotransmitters (dopamine, serotonin, norepinephrine) and its almost cocaine like stimulation and anesthetic ability (cocaine is a local anesthetic) plus its very fast action makes it more addictive than other IV drugs, it has multiple major drug interactions, does not fully respond to opiate antagonists like Naloxone (for use in OD situations as an antidote), and it is actually toxic (a neurotoxin). One things opiates, especially naturally occurring and semisynthetic opiates, are known for are being "clean" drugs. This means that opiates like morphine do not interact with many neurotransmitters and receptors. So opiates have targeted action. Demerol acts with all sorts of neurotransmitters and has active metabolites that can damage the body. It is almost like morphine and cocaine mixed together hitting the brain in seconds after given IV. Thus it is far more addictive and has the potential for many problems (including cardiac). But it is not exactly a bad drug. Short term use is normally safe and people with certain medical conditions or who do not respond well to morphine and related drugs might use Demerol. It is available in tablet forms that people can take at home for pain. And it is very rare for IV Demerol to be needed except in hospital or home hospice. I can't imagine Jackson was in enough pain that he required daily shots of IV Demerol. Oral pain medication is typically effective in all but extreme situations. Answered by Virgina Starace 2 years ago.

Toxic buildup is not the problem, addiction is. Demerol is a derivative of opium, similar to morphine. It is very effective as a pain killer, especially after a surgical procedure. Thus, it is almost ideal for short term use. For reasons that are not completely clear, some persons are more prone to addiction than others. Giving Demerol to these persons over an extended period of time is inadvisable. Many physicians are not astute as to the warning signs. Asking for repeated prescription refills is one huge red flag. Answered by Tai Rothgaber 2 years ago.

It is physically addictive and your body begins to build a tolerance to opiates. Over a long period of time the patient will need larger and larger doses of Vicodin to relieve their pain. Answered by Lamar Bache 2 years ago.


Does anyone know if there is a doctor that uses Demerol for pain?
I have a lot of headaches for over 40 year now. During my fifteenth year of these headaches I was sitting at work when my head thought it was going to blow apart, I have never in my life had a pain that felt like my brains were going to explode outward, I called my Dad and said :You've got to take me to the... Asked by Mittie Oseguera 2 years ago.

I have a lot of headaches for over 40 year now. During my fifteenth year of these headaches I was sitting at work when my head thought it was going to blow apart, I have never in my life had a pain that felt like my brains were going to explode outward, I called my Dad and said :You've got to take me to the hospital ASAP as I think I am about to die,,,,and I really felt like i was going to die. I was saying my last prayers and I was crying eyes out over all the missed opportunity to do the things I should have done. Then I got to the ER and the doctor gave me a shot of 125 mg Demerol. My dad was in the room with me and I was complaining as to how much my head was still hurt,,,,,ing,,,,did I say HURT ng..........OMG .......it doesn.t hurt anymore...........I can't believe WHAT WAS THAT STUFF????? They told me it was called Demerol. This medicine took my 5 day headache away in 15 minutes. I want to know who has been hiding this stuff all this time. The ER's I go to tell they are using Dilaudid now and phasing out Demerol. That is sad, myself and many , many others believe that Demerol is the best headache medicine out there. If anyone knows which doctor would be willing to administer it, I would very very greatfull and thank you.Thank You and Thank You Answered by Heike Cheaney 2 years ago.

Demerol is still used although its use is in decline. Some hospitals have phased it out and it is not commonly prescribed out patient. Unlike other full opioid agonists (eg methadone, morphine, hydromorphone, oxymorphone) Demerol has a maximum dose, it is significantly neurotoxic and cardiotoxic in even modest doses or when taken too long, it tends to be more abused than other opioids (likely because it has opioid effects and it also has some pharmacological properties of cocaine). Demerol can only be taken for about two weeks at a time whereas most other opioids don't have a limit. I hear similar things from patients all the time. People with extremely severe headaches tend to respond extremely well to Demerol. In addition some consider Demerol to be the best drug to provide the most rapid and effective analgesia. Also hospitals try to avoid using opioids when a patients presents with a headache. However the reality is that opioids are extremely effective treatment to stop the pain once it starts and about 68% of the time opioids are used. People who only have occasional headaches are often prescribed opioids and/or barbiturates because they work so well. If you only have an occasional headache many doctors would likely be willing to prescribe a small number of Demerol tablets (in Canada there are 50 mg tabs and in America I believe there are 50 and 100 mg tabs). And doctors certainly do not administer IV Demerol except in hospital. You are just going to have to see a doctor about treatment. Other medications are something to consider. I will tell you that asking for Demerol and refusing to consider other treatment will make you look like a drug seeker. Answered by Reagan Barkett 2 years ago.

Demerol Uses Answered by Haywood Mccright 2 years ago.

Yes, they are phasing out Demerol permanently because it breaks down in the body into toxic substances. For headaches now they use a mix of Toradol (NSAID), anti nausea med (usually Zofran) and sometimes IV Benedryl. Does the same thing as Demerol for 1/2 the price, AND there are no opiates in any of them, so we can discharge patients faster. Answered by Wynell Colgin 2 years ago.

The prescription of meperidine or demerol is for moderate to severe pain. If your pain is really really so bad that you can feel your head bursting open, the pain is even worse than getting your head smashed by a beer bottle you should go to your doctor again to explain the situation. Demerol has too many complication when taken. Answered by Latanya Pinales 2 years ago.


How is Demerol administered--IV, IM, or both. About how much time before side effects would become apparent?
Also, what would be perhaps the initial side effects? Thank you Asked by Delinda Messan 2 years ago.

Demerol can be given in pill form as well as IM or IV but usually the prescriptions are only given to patients in pill form for obvious reasons since shots & IV use are usually by medical personnel. With pill form usually the effect is felt in 30 minutes after pill dissolves.IV dose is felt within 1-2 minutes.IM dose is usually felt in 15-20 minutes (unless patient has other drugs in the system which may cause it to be earlier).Patients normally start to feel relaxed then say the pain starts to ease off.They often complain of being light headed & sleepy. Literature says the pain is relieved for 4 hours but in my experience patients start to complain of pain again in 3 hours.Demerol is really not a good drug for chronic pain management. Morphine lasts longer & easier to use in terminal patients.Demerol should only be used for short term patients & also not those mixing other opiates. Answered by Suzette Bartlette 2 years ago.

This Site Might Help You. RE: How is Demerol administered--IV, IM, or both. About how much time before side effects would become apparent? Also, what would be perhaps the initial side effects? Thank you Answered by Bula Peckenpaugh 2 years ago.

This I happen to know. Demerol can be administered either way. When administered IV, the drug takes effect immediately [depending on the strength] IM, about 15 min. 50mg to 100mg are the preferred dosage. Side effects include foggy brain, thick tongue and not being able to say "no", sexually speaking. I know this first hand. Enjoy the feeling. Answered by Rico Toft 2 years ago.


What does Demerol do? Is it as effective as an epidural?
Asked by Tanna Havas 2 years ago.

Demerol is a narcotic that will take the edge off of your pains and makes you feel a little elevated if you will!! It doesn't last that long, maybe an hour or 2 if your lucky and is best used towards the end of your labor as you are only allowed so many doses throughout your labor!! It is not nearly effective as an epidural because with the Demerol, you still feel your contractions, it just takes the edge off of it where as with the epidural, you are completely numb and can't feel anything until they lower your epidural medication!! Answered by Laci Brazile 2 years ago.

demerol is a shot that is givenin the arm or hip sometimes given in an IV that is used to dull the pain and relax the mom so she can cope with the pain of contractions it's usually given every 2 to 4 hours.. it makes you feel drowsy it also sometimes causes nauses vomiting and a drop in blood pressure. and it sometimes does effect the babys breathing patterns and ability to suck right after delivery but the side effects wear off.. and epideral is administrated by a large needle into the epideral space of the spine. the needle will insert a small catheter into the space in which the medication will be released... this will numb your lower half of your body.. they can set the drip so you can feel some so your not completely numb to the experience.. from what i've read the only effect this can have on the baby is slowing the heart rate down on some... Answered by Xavier Niziolek 2 years ago.

No, all demerol does is make you feel more at ease..kinda high if you will. Epidural is a shot given to you in your back and it numbs your lower body. Answered by Dwain Golanski 2 years ago.

No its not as effective as an epidural, demerol makes you groggy and less aware of the situation . epidural makes you numb but doesn't mess iwth your mind state. Answered by Tyra Difillippo 2 years ago.

demerol is nothing like the epidural, opt for the epidural so u can at least be awake when you deliver. Answered by Rosia Gosson 2 years ago.

It makes you drowsy and unaware the epidural numbs from the waist down and doesnt make you drowsy in both births I had epidurals I waouldnt suggest the demoral but everyone is different Answered by Herminia Calbert 2 years ago.

ive had demerol once, non pregnancy related...and im terribly allergic. Apparently. It gave me a really horrible rash, i had to get a shot to make it go away. it was all kinds of bad for me. Answered by Anisa Guiden 2 years ago.


How is Demerol made?
Asked by Creola Knerien 2 years ago.

Isonicotinic Acid Methochloride. To a slurry of 246 g of isonicotinic acid in 3.2 liters of methanol and 300 ml of water containing 88 g of sodium hydroxide has 355 g of methyl iodide added to it. Note: Isonicotinic acid can be replaced with nicotinic acid, thus producing B-pethidine, instead of demerol. There is very little difference in potency between these two drugs and the formula does not change (just use an equimolar amount of nicotinic acid), so you may use either acid. Stir and reflux the above mixture for 60 hours, then remove the methanol with vacuo. Use sodium thiosulfate to reduce iodine to iodide and add water to give a volume of 1.5 liters. Use hydrochloric acid (concd) to get a ph of 2.0. Place a slurry of Amberlite IRA-400 (6.30 equivalents) in a glass tube 10 cm in diameter and 100 cm high. The resin is washed with 20 x 1. of 5% hydrochloric acid followed with 40 x 1. of distilled water. The yellow aqueous solution is passed through the column and the effluent, which had better be iodine free, is collected at a rate of flow of 50 ml per min. Three and one half liters of effluent is coned and the residue is dried and extracted with acetic acid. Xylene is added to the hot acetic acid solution, then cooled, and saturated with dry hydrogen chloride to give 336 g of crude product. Recrystallize from acetic acid to purify. 1-Methyl-4-carboxypiperidine Hydrochloride. Isonicotinic acid methochloride is quantitively reduced in a high pressure reaction vessel in the presence of platinum oxide in methanol at 1,000 psi, mp: 231-232°. 1-Methyl-4-chloro-4-benzoylpiperidine Hydrochloride. Chlorine gas is slowly passed (bubbled) into a solution of 48 g of the above product in 500 ml of glacial acetic acid for 8 hours at 70°. The volume is evaporated to 150 ml and 1 1iter of dry ether is added. The resulting white powder is recrystallized from chloroform, yielding 45 g of the hydrochloric salt, mp: 181° to 182°. This is then recrystallized from Skelly A, mp: 48-49°C. Rearrangement of 1-Mehtyl-4-chloro-4-benzoylpiperidine. Add 50 ml of xylene (containing 3.5 g of the above product) to a stirred refluxing solution containing 200 ml dry xylene and 18 g of finely powdered, dried sodium NaOH. Stir while refluxing for 30 min, then cool, extract with 25 ml portion of water until the ph of the extracts reaches neutrality (approximately). The combined water extracts are washed with three 25 ml portions of ether and adjusted to 8 ph with hydrochloric acid. The aqueous solution is concentrated to 50 ml (by evaporation in vacuo), filtered, and acidified to 6.5 with hydrochloric acid. The solution is cooled and the crystals are washed with water, acetone, ether, and then dried. Recrystallize from water to get fine, white needles of 1-methyl-4-phenyl-4-carboxy- piperidine. Yield: 0.8 g, mp: 309-310°. This product is then dissolved in ether and treated by passing dry hydrogen chloride through this solution and recrystallizing the resulting salt from acetic acid-benzene. Take the above hydrochloride salt and reflux it in ethanolic hydrogen chloride to get Demerol or analog. Now, you need to know that if you get it wrong, you may end up with a drug that causes irreversible Parkinsonism. If you use too much Demerol, there is a metabolite that will build up and knock off your kidneys. BTW, I left out a step. It's really not something an amateur can cook up. Answered by Delois Arteaga 2 years ago.

What Is Demerol Made Of Answered by Alyson Biegler 2 years ago.

Active Ingredient: Meperidine Hydrochloride Inactive Ingredients Tablets: Calcium Sulfate, Dibasic Calcium phosphate, Starch, Stearic Acid, Talc. Syrup: Benzoic Acid, Flavor, Liquid Glucose, Purified Water, Saccharin Sodium. Answered by Jennette Wittenbrink 2 years ago.

You dont feel the spinal cathedar once the med takes effect. It can only make labor go longer if there is a lot of meds and the woman cant feel anything, like no pressure. Doesnt matter the baby will come your body will push it out on its own if it had to. It lasts and wears off times differ per person and how often they push the little button to administer more medication. Every Dr and hospital are different some take it out if your going to push because they want you to feel the pressure, some dont mind if the partner is in the room as long as they stay out of the way of the anesthesiologist, but then some have policy that no one but the nurse and anesthesiologist can be in the room with the woman. Mine didnt work with any of my labors and deliveries, many women have epidurals and they work great, many women have them and they dont work at all. just know you did with out before and you were fine, you can do it, but I hope you are able to get a pain med if you want one, they do work wonderfully when they work, good luck~ Answered by Ruthe Tehney 2 years ago.

Check out www.wikipedia.com and search for Pethidine. Find the basic ingredients for synthesis then using basic knowledge of synthetic organic chemistry, make some demerol. Oh and by the way, it is illegal to make unless you are a licensed pharmaceutical company. Its not as easy as making crack or meth...so stick to those. And for future reference, please don't ask questions on how to make drugs. Answered by Tyree Stick 2 years ago.


Question about the drug demerol/pethidine..?
True John. But at least we know the heroin is being supplied on the black market, not administered illegally by rogue doctors. Asked by Andreas Sapinski 2 years ago.

Demerol (pethidine/meperidine) is a synthetic opiate analgesic and it is a schedule II drug in The United States, Schedule I in Canada, and Class A in The UK. In just about any country Demerol would fall under the highest levels of control. But it is prescribed for patients all of the time. It is very commonly given (in hospital) for migraine that does not respond to other drugs. Some people doctor shop and get reasonable amount of narcotics from each doctor- but from 4 or 5 doctors and end up with a large amount of drugs. And there are very shady doctors out there who prescribe drugs as if it were nothing, sometimes because they are incompetent other times to satisfy a paying customer. And personal doctors are a bit more likely to doll out whatever the patient "needs." In many cases where The DEA revokes a doctors DEA number (required to give controlled substances) the doctor was giving out drugs in extreme excess. I know of one case where one doctor wrote 90 prescriptions for OxyContin to one person over 6 months or so. Also if you have a good relationship with your doctor and you have known each other for years and years then a doctor would probably be more amiable to prescribe any drug, but only to a point. Most doctors will not prescribe IV Demerol outside of a hospital/hospice. IV opiates are really only needed in emergency situations (morphine for heart attack) or for cancer, AIDS, and other conditions that can cause extreme pain. Answered by Naoma Chessor 2 years ago.

I'm not in California but all the states must follow the Federal laws governing narcotics. Demerol is strictly controlled but as in many celebrity situations there are doctors willing to bend the law to be near the limelight.Demerol is rarely used for pain & is given in tablet form by prescription only if other narcotics either don't work or a patient is allergic to codeine, oxycodone, and morphine (doctors better document this too for the Feds will yank their license if they find no records being kept...this applies in all narcotic prescriptions).Demerol is commonly used in hospitals for surgical patients & properly used short term only.It's not good for chronic use. In Hospice we almost never use Demerol for Morphine works much better for chronic pain as does Fentanyl. I've worked as a nurse for over 40 years and anytime someone asked for Demerol...they never got it and were looked on with suspicion for we knew they were addicts.I can truthfully say I've only seen prescriptions for Demerol for anyone outside the hospital setting maybe 6 times, mostly in tablet form & only 12 pills (dentists mostly post extraction).Celebrity Demerol isn't proper medicine. Answered by Elizbeth Rann 2 years ago.

It's also strictly controlled in the US. If rumors are even vaguely close to true, then it wouldn't be surprising for MJ's physician to have hired an attorney at least in part because of a risk of losing his narcotic licensure, and perhaps even his license to practice medicine. On the other hand, there is no drug that can't be had by the wealthy or the determined. Certainly even heroin addiction is far from unknown in the UK! Answered by Theo Tenpas 2 years ago.

I had an epidural last year and I was numb for a few hours after having my daughter. I had to have the nurses help me walk to the bathroom to take a bath. I dont think everyone is numb for hours I think it depends how long you have the epidural on for. I was in labor for 17 hours and I had the epidural for about 14 hours or so. Dont worry about it, after you give birth you may feel too tired to even get up so dont worry too much. You'll be fine! Answered by Damaris Valdo 2 years ago.

Lestermount Answered by Florine Winzelberg 2 years ago.


If Demerol is not supposed to used in treating long term pain management, how long would it be used for?
If Demerol is not safe for long term treatment of pain because of toxic buildup what would be the generally accepted period of time that it is safe to use? Would it be days, weeks, etc? The Michael Jackson case has sparked my curiosity. Thank you. Asked by Sharda Weik 2 years ago.

Demerol is used for the treatment of chronic pain and acute pain. Many doctors prefer Demerol to other opiate analgesics due to some of its unique properties (but it falls more out of favour every year). However, some of its unique properties involving the reuptake of monoamine neurotransmitters (dopamine, serotonin, norepinephrine) and its almost cocaine like stimulation and anesthetic ability (cocaine is a local anesthetic) plus its very fast action makes it more addictive than other IV drugs, it has multiple major drug interactions, does not fully respond to opiate antagonists like Naloxone (for use in OD situations as an antidote), and it is actually toxic (a neurotoxin). One things opiates, especially naturally occurring and semisynthetic opiates, are known for are being "clean" drugs. This means that opiates like morphine do not interact with many neurotransmitters and receptors. So opiates have targeted action. Demerol acts with all sorts of neurotransmitters and has active metabolites that can damage the body. It is almost like morphine and cocaine mixed together hitting the brain in seconds after given IV. Thus it is far more addictive and has the potential for many problems (including cardiac). But it is not exactly a bad drug. Short term use is normally safe and people with certain medical conditions or who do not respond well to morphine and related drugs might use Demerol. It is available in tablet forms that people can take at home for pain. And it is very rare for IV Demerol to be needed except in hospital or home hospice. I can't imagine Jackson was in enough pain that he required daily shots of IV Demerol. Oral pain medication is typically effective in all but extreme situations. Answered by Seymour Valdivia 2 years ago.

Toxic buildup is not the problem, addiction is. Demerol is a derivative of opium, similar to morphine. It is very effective as a pain killer, especially after a surgical procedure. Thus, it is almost ideal for short term use. For reasons that are not completely clear, some persons are more prone to addiction than others. Giving Demerol to these persons over an extended period of time is inadvisable. Many physicians are not astute as to the warning signs. Asking for repeated prescription refills is one huge red flag. Answered by Raisa Keovongxay 2 years ago.

It is physically addictive and your body begins to build a tolerance to opiates. Over a long period of time the patient will need larger and larger doses of Vicodin to relieve their pain. Answered by Eliana Ragsdale 2 years ago.


Does anyone know if there is a doctor that uses Demerol for pain?
I have a lot of headaches for over 40 year now. During my fifteenth year of these headaches I was sitting at work when my head thought it was going to blow apart, I have never in my life had a pain that felt like my brains were going to explode outward, I called my Dad and said :You've got to take me to the... Asked by Rubie Marsac 2 years ago.

I have a lot of headaches for over 40 year now. During my fifteenth year of these headaches I was sitting at work when my head thought it was going to blow apart, I have never in my life had a pain that felt like my brains were going to explode outward, I called my Dad and said :You've got to take me to the hospital ASAP as I think I am about to die,,,,and I really felt like i was going to die. I was saying my last prayers and I was crying eyes out over all the missed opportunity to do the things I should have done. Then I got to the ER and the doctor gave me a shot of 125 mg Demerol. My dad was in the room with me and I was complaining as to how much my head was still hurt,,,,,ing,,,,did I say HURT ng..........OMG .......it doesn.t hurt anymore...........I can't believe WHAT WAS THAT STUFF????? They told me it was called Demerol. This medicine took my 5 day headache away in 15 minutes. I want to know who has been hiding this stuff all this time. The ER's I go to tell they are using Dilaudid now and phasing out Demerol. That is sad, myself and many , many others believe that Demerol is the best headache medicine out there. If anyone knows which doctor would be willing to administer it, I would very very greatfull and thank you.Thank You and Thank You Answered by Robert Eliot 2 years ago.

Demerol is still used although its use is in decline. Some hospitals have phased it out and it is not commonly prescribed out patient. Unlike other full opioid agonists (eg methadone, morphine, hydromorphone, oxymorphone) Demerol has a maximum dose, it is significantly neurotoxic and cardiotoxic in even modest doses or when taken too long, it tends to be more abused than other opioids (likely because it has opioid effects and it also has some pharmacological properties of cocaine). Demerol can only be taken for about two weeks at a time whereas most other opioids don't have a limit. I hear similar things from patients all the time. People with extremely severe headaches tend to respond extremely well to Demerol. In addition some consider Demerol to be the best drug to provide the most rapid and effective analgesia. Also hospitals try to avoid using opioids when a patients presents with a headache. However the reality is that opioids are extremely effective treatment to stop the pain once it starts and about 68% of the time opioids are used. People who only have occasional headaches are often prescribed opioids and/or barbiturates because they work so well. If you only have an occasional headache many doctors would likely be willing to prescribe a small number of Demerol tablets (in Canada there are 50 mg tabs and in America I believe there are 50 and 100 mg tabs). And doctors certainly do not administer IV Demerol except in hospital. You are just going to have to see a doctor about treatment. Other medications are something to consider. I will tell you that asking for Demerol and refusing to consider other treatment will make you look like a drug seeker. Answered by Hugh Arichabala 2 years ago.

Demerol Uses Answered by Paulita Freiheit 2 years ago.

Yes, they are phasing out Demerol permanently because it breaks down in the body into toxic substances. For headaches now they use a mix of Toradol (NSAID), anti nausea med (usually Zofran) and sometimes IV Benedryl. Does the same thing as Demerol for 1/2 the price, AND there are no opiates in any of them, so we can discharge patients faster. Answered by Everett Castillon 2 years ago.

The prescription of meperidine or demerol is for moderate to severe pain. If your pain is really really so bad that you can feel your head bursting open, the pain is even worse than getting your head smashed by a beer bottle you should go to your doctor again to explain the situation. Demerol has too many complication when taken. Answered by Karie Faigin 2 years ago.


How is Demerol administered--IV, IM, or both. About how much time before side effects would become apparent?
Also, what would be perhaps the initial side effects? Thank you Asked by Larraine Doiley 2 years ago.

Demerol can be given in pill form as well as IM or IV but usually the prescriptions are only given to patients in pill form for obvious reasons since shots & IV use are usually by medical personnel. With pill form usually the effect is felt in 30 minutes after pill dissolves.IV dose is felt within 1-2 minutes.IM dose is usually felt in 15-20 minutes (unless patient has other drugs in the system which may cause it to be earlier).Patients normally start to feel relaxed then say the pain starts to ease off.They often complain of being light headed & sleepy. Literature says the pain is relieved for 4 hours but in my experience patients start to complain of pain again in 3 hours.Demerol is really not a good drug for chronic pain management. Morphine lasts longer & easier to use in terminal patients.Demerol should only be used for short term patients & also not those mixing other opiates. Answered by Sofia Shippy 2 years ago.

This Site Might Help You. RE: How is Demerol administered--IV, IM, or both. About how much time before side effects would become apparent? Also, what would be perhaps the initial side effects? Thank you Answered by Sadye Spinelli 2 years ago.

This I happen to know. Demerol can be administered either way. When administered IV, the drug takes effect immediately [depending on the strength] IM, about 15 min. 50mg to 100mg are the preferred dosage. Side effects include foggy brain, thick tongue and not being able to say "no", sexually speaking. I know this first hand. Enjoy the feeling. Answered by Missy Straker 2 years ago.


What does Demerol do? Is it as effective as an epidural?
Asked by Rosario Stamour 2 years ago.

Demerol is a narcotic that will take the edge off of your pains and makes you feel a little elevated if you will!! It doesn't last that long, maybe an hour or 2 if your lucky and is best used towards the end of your labor as you are only allowed so many doses throughout your labor!! It is not nearly effective as an epidural because with the Demerol, you still feel your contractions, it just takes the edge off of it where as with the epidural, you are completely numb and can't feel anything until they lower your epidural medication!! Answered by Joe Kolmer 2 years ago.

demerol is a shot that is givenin the arm or hip sometimes given in an IV that is used to dull the pain and relax the mom so she can cope with the pain of contractions it's usually given every 2 to 4 hours.. it makes you feel drowsy it also sometimes causes nauses vomiting and a drop in blood pressure. and it sometimes does effect the babys breathing patterns and ability to suck right after delivery but the side effects wear off.. and epideral is administrated by a large needle into the epideral space of the spine. the needle will insert a small catheter into the space in which the medication will be released... this will numb your lower half of your body.. they can set the drip so you can feel some so your not completely numb to the experience.. from what i've read the only effect this can have on the baby is slowing the heart rate down on some... Answered by Cathie Wegley 2 years ago.

No, all demerol does is make you feel more at ease..kinda high if you will. Epidural is a shot given to you in your back and it numbs your lower body. Answered by Kathryne Rybarczyk 2 years ago.

No its not as effective as an epidural, demerol makes you groggy and less aware of the situation . epidural makes you numb but doesn't mess iwth your mind state. Answered by Roberta Newhart 2 years ago.

demerol is nothing like the epidural, opt for the epidural so u can at least be awake when you deliver. Answered by Valorie Kilgallon 2 years ago.

It makes you drowsy and unaware the epidural numbs from the waist down and doesnt make you drowsy in both births I had epidurals I waouldnt suggest the demoral but everyone is different Answered by Chung Cerao 2 years ago.

ive had demerol once, non pregnancy related...and im terribly allergic. Apparently. It gave me a really horrible rash, i had to get a shot to make it go away. it was all kinds of bad for me. Answered by Reanna Perkerson 2 years ago.


How is Demerol made?
Asked by Roxanne Hirth 2 years ago.

Isonicotinic Acid Methochloride. To a slurry of 246 g of isonicotinic acid in 3.2 liters of methanol and 300 ml of water containing 88 g of sodium hydroxide has 355 g of methyl iodide added to it. Note: Isonicotinic acid can be replaced with nicotinic acid, thus producing B-pethidine, instead of demerol. There is very little difference in potency between these two drugs and the formula does not change (just use an equimolar amount of nicotinic acid), so you may use either acid. Stir and reflux the above mixture for 60 hours, then remove the methanol with vacuo. Use sodium thiosulfate to reduce iodine to iodide and add water to give a volume of 1.5 liters. Use hydrochloric acid (concd) to get a ph of 2.0. Place a slurry of Amberlite IRA-400 (6.30 equivalents) in a glass tube 10 cm in diameter and 100 cm high. The resin is washed with 20 x 1. of 5% hydrochloric acid followed with 40 x 1. of distilled water. The yellow aqueous solution is passed through the column and the effluent, which had better be iodine free, is collected at a rate of flow of 50 ml per min. Three and one half liters of effluent is coned and the residue is dried and extracted with acetic acid. Xylene is added to the hot acetic acid solution, then cooled, and saturated with dry hydrogen chloride to give 336 g of crude product. Recrystallize from acetic acid to purify. 1-Methyl-4-carboxypiperidine Hydrochloride. Isonicotinic acid methochloride is quantitively reduced in a high pressure reaction vessel in the presence of platinum oxide in methanol at 1,000 psi, mp: 231-232°. 1-Methyl-4-chloro-4-benzoylpiperidine Hydrochloride. Chlorine gas is slowly passed (bubbled) into a solution of 48 g of the above product in 500 ml of glacial acetic acid for 8 hours at 70°. The volume is evaporated to 150 ml and 1 1iter of dry ether is added. The resulting white powder is recrystallized from chloroform, yielding 45 g of the hydrochloric salt, mp: 181° to 182°. This is then recrystallized from Skelly A, mp: 48-49°C. Rearrangement of 1-Mehtyl-4-chloro-4-benzoylpiperidine. Add 50 ml of xylene (containing 3.5 g of the above product) to a stirred refluxing solution containing 200 ml dry xylene and 18 g of finely powdered, dried sodium NaOH. Stir while refluxing for 30 min, then cool, extract with 25 ml portion of water until the ph of the extracts reaches neutrality (approximately). The combined water extracts are washed with three 25 ml portions of ether and adjusted to 8 ph with hydrochloric acid. The aqueous solution is concentrated to 50 ml (by evaporation in vacuo), filtered, and acidified to 6.5 with hydrochloric acid. The solution is cooled and the crystals are washed with water, acetone, ether, and then dried. Recrystallize from water to get fine, white needles of 1-methyl-4-phenyl-4-carboxy- piperidine. Yield: 0.8 g, mp: 309-310°. This product is then dissolved in ether and treated by passing dry hydrogen chloride through this solution and recrystallizing the resulting salt from acetic acid-benzene. Take the above hydrochloride salt and reflux it in ethanolic hydrogen chloride to get Demerol or analog. Now, you need to know that if you get it wrong, you may end up with a drug that causes irreversible Parkinsonism. If you use too much Demerol, there is a metabolite that will build up and knock off your kidneys. BTW, I left out a step. It's really not something an amateur can cook up. Answered by Carrol Ferman 2 years ago.

What Is Demerol Made Of Answered by Efrain Beaz 2 years ago.

Active Ingredient: Meperidine Hydrochloride Inactive Ingredients Tablets: Calcium Sulfate, Dibasic Calcium phosphate, Starch, Stearic Acid, Talc. Syrup: Benzoic Acid, Flavor, Liquid Glucose, Purified Water, Saccharin Sodium. Answered by Marica Stoebner 2 years ago.

You dont feel the spinal cathedar once the med takes effect. It can only make labor go longer if there is a lot of meds and the woman cant feel anything, like no pressure. Doesnt matter the baby will come your body will push it out on its own if it had to. It lasts and wears off times differ per person and how often they push the little button to administer more medication. Every Dr and hospital are different some take it out if your going to push because they want you to feel the pressure, some dont mind if the partner is in the room as long as they stay out of the way of the anesthesiologist, but then some have policy that no one but the nurse and anesthesiologist can be in the room with the woman. Mine didnt work with any of my labors and deliveries, many women have epidurals and they work great, many women have them and they dont work at all. just know you did with out before and you were fine, you can do it, but I hope you are able to get a pain med if you want one, they do work wonderfully when they work, good luck~ Answered by Alyce Weddington 2 years ago.

Check out www.wikipedia.com and search for Pethidine. Find the basic ingredients for synthesis then using basic knowledge of synthetic organic chemistry, make some demerol. Oh and by the way, it is illegal to make unless you are a licensed pharmaceutical company. Its not as easy as making crack or meth...so stick to those. And for future reference, please don't ask questions on how to make drugs. Answered by Shaneka Hamer 2 years ago.


Question about the drug demerol/pethidine..?
True John. But at least we know the heroin is being supplied on the black market, not administered illegally by rogue doctors. Asked by Freeman Rhyner 2 years ago.

Demerol (pethidine/meperidine) is a synthetic opiate analgesic and it is a schedule II drug in The United States, Schedule I in Canada, and Class A in The UK. In just about any country Demerol would fall under the highest levels of control. But it is prescribed for patients all of the time. It is very commonly given (in hospital) for migraine that does not respond to other drugs. Some people doctor shop and get reasonable amount of narcotics from each doctor- but from 4 or 5 doctors and end up with a large amount of drugs. And there are very shady doctors out there who prescribe drugs as if it were nothing, sometimes because they are incompetent other times to satisfy a paying customer. And personal doctors are a bit more likely to doll out whatever the patient "needs." In many cases where The DEA revokes a doctors DEA number (required to give controlled substances) the doctor was giving out drugs in extreme excess. I know of one case where one doctor wrote 90 prescriptions for OxyContin to one person over 6 months or so. Also if you have a good relationship with your doctor and you have known each other for years and years then a doctor would probably be more amiable to prescribe any drug, but only to a point. Most doctors will not prescribe IV Demerol outside of a hospital/hospice. IV opiates are really only needed in emergency situations (morphine for heart attack) or for cancer, AIDS, and other conditions that can cause extreme pain. Answered by Dot Czarniecki 2 years ago.

I'm not in California but all the states must follow the Federal laws governing narcotics. Demerol is strictly controlled but as in many celebrity situations there are doctors willing to bend the law to be near the limelight.Demerol is rarely used for pain & is given in tablet form by prescription only if other narcotics either don't work or a patient is allergic to codeine, oxycodone, and morphine (doctors better document this too for the Feds will yank their license if they find no records being kept...this applies in all narcotic prescriptions).Demerol is commonly used in hospitals for surgical patients & properly used short term only.It's not good for chronic use. In Hospice we almost never use Demerol for Morphine works much better for chronic pain as does Fentanyl. I've worked as a nurse for over 40 years and anytime someone asked for Demerol...they never got it and were looked on with suspicion for we knew they were addicts.I can truthfully say I've only seen prescriptions for Demerol for anyone outside the hospital setting maybe 6 times, mostly in tablet form & only 12 pills (dentists mostly post extraction).Celebrity Demerol isn't proper medicine. Answered by Matilde Aubry 2 years ago.

It's also strictly controlled in the US. If rumors are even vaguely close to true, then it wouldn't be surprising for MJ's physician to have hired an attorney at least in part because of a risk of losing his narcotic licensure, and perhaps even his license to practice medicine. On the other hand, there is no drug that can't be had by the wealthy or the determined. Certainly even heroin addiction is far from unknown in the UK! Answered by Sau Koor 2 years ago.

I had an epidural last year and I was numb for a few hours after having my daughter. I had to have the nurses help me walk to the bathroom to take a bath. I dont think everyone is numb for hours I think it depends how long you have the epidural on for. I was in labor for 17 hours and I had the epidural for about 14 hours or so. Dont worry about it, after you give birth you may feel too tired to even get up so dont worry too much. You'll be fine! Answered by Marine Gonzalos 2 years ago.

Lestermount Answered by Terrell Koob 2 years ago.


If Demerol is not supposed to used in treating long term pain management, how long would it be used for?
If Demerol is not safe for long term treatment of pain because of toxic buildup what would be the generally accepted period of time that it is safe to use? Would it be days, weeks, etc? The Michael Jackson case has sparked my curiosity. Thank you. Asked by Oswaldo Bellah 2 years ago.

Demerol is used for the treatment of chronic pain and acute pain. Many doctors prefer Demerol to other opiate analgesics due to some of its unique properties (but it falls more out of favour every year). However, some of its unique properties involving the reuptake of monoamine neurotransmitters (dopamine, serotonin, norepinephrine) and its almost cocaine like stimulation and anesthetic ability (cocaine is a local anesthetic) plus its very fast action makes it more addictive than other IV drugs, it has multiple major drug interactions, does not fully respond to opiate antagonists like Naloxone (for use in OD situations as an antidote), and it is actually toxic (a neurotoxin). One things opiates, especially naturally occurring and semisynthetic opiates, are known for are being "clean" drugs. This means that opiates like morphine do not interact with many neurotransmitters and receptors. So opiates have targeted action. Demerol acts with all sorts of neurotransmitters and has active metabolites that can damage the body. It is almost like morphine and cocaine mixed together hitting the brain in seconds after given IV. Thus it is far more addictive and has the potential for many problems (including cardiac). But it is not exactly a bad drug. Short term use is normally safe and people with certain medical conditions or who do not respond well to morphine and related drugs might use Demerol. It is available in tablet forms that people can take at home for pain. And it is very rare for IV Demerol to be needed except in hospital or home hospice. I can't imagine Jackson was in enough pain that he required daily shots of IV Demerol. Oral pain medication is typically effective in all but extreme situations. Answered by Jerrie Heape 2 years ago.

Toxic buildup is not the problem, addiction is. Demerol is a derivative of opium, similar to morphine. It is very effective as a pain killer, especially after a surgical procedure. Thus, it is almost ideal for short term use. For reasons that are not completely clear, some persons are more prone to addiction than others. Giving Demerol to these persons over an extended period of time is inadvisable. Many physicians are not astute as to the warning signs. Asking for repeated prescription refills is one huge red flag. Answered by Isaiah Howieson 2 years ago.

It is physically addictive and your body begins to build a tolerance to opiates. Over a long period of time the patient will need larger and larger doses of Vicodin to relieve their pain. Answered by Tom Dymek 2 years ago.


Does anyone know if there is a doctor that uses Demerol for pain?
I have a lot of headaches for over 40 year now. During my fifteenth year of these headaches I was sitting at work when my head thought it was going to blow apart, I have never in my life had a pain that felt like my brains were going to explode outward, I called my Dad and said :You've got to take me to the... Asked by Priscila Delafuente 2 years ago.

I have a lot of headaches for over 40 year now. During my fifteenth year of these headaches I was sitting at work when my head thought it was going to blow apart, I have never in my life had a pain that felt like my brains were going to explode outward, I called my Dad and said :You've got to take me to the hospital ASAP as I think I am about to die,,,,and I really felt like i was going to die. I was saying my last prayers and I was crying eyes out over all the missed opportunity to do the things I should have done. Then I got to the ER and the doctor gave me a shot of 125 mg Demerol. My dad was in the room with me and I was complaining as to how much my head was still hurt,,,,,ing,,,,did I say HURT ng..........OMG .......it doesn.t hurt anymore...........I can't believe WHAT WAS THAT STUFF????? They told me it was called Demerol. This medicine took my 5 day headache away in 15 minutes. I want to know who has been hiding this stuff all this time. The ER's I go to tell they are using Dilaudid now and phasing out Demerol. That is sad, myself and many , many others believe that Demerol is the best headache medicine out there. If anyone knows which doctor would be willing to administer it, I would very very greatfull and thank you.Thank You and Thank You Answered by Hortensia Caldeira 2 years ago.

Demerol is still used although its use is in decline. Some hospitals have phased it out and it is not commonly prescribed out patient. Unlike other full opioid agonists (eg methadone, morphine, hydromorphone, oxymorphone) Demerol has a maximum dose, it is significantly neurotoxic and cardiotoxic in even modest doses or when taken too long, it tends to be more abused than other opioids (likely because it has opioid effects and it also has some pharmacological properties of cocaine). Demerol can only be taken for about two weeks at a time whereas most other opioids don't have a limit. I hear similar things from patients all the time. People with extremely severe headaches tend to respond extremely well to Demerol. In addition some consider Demerol to be the best drug to provide the most rapid and effective analgesia. Also hospitals try to avoid using opioids when a patients presents with a headache. However the reality is that opioids are extremely effective treatment to stop the pain once it starts and about 68% of the time opioids are used. People who only have occasional headaches are often prescribed opioids and/or barbiturates because they work so well. If you only have an occasional headache many doctors would likely be willing to prescribe a small number of Demerol tablets (in Canada there are 50 mg tabs and in America I believe there are 50 and 100 mg tabs). And doctors certainly do not administer IV Demerol except in hospital. You are just going to have to see a doctor about treatment. Other medications are something to consider. I will tell you that asking for Demerol and refusing to consider other treatment will make you look like a drug seeker. Answered by Micaela Lomack 2 years ago.

Demerol Uses Answered by Timika Killean 2 years ago.

Yes, they are phasing out Demerol permanently because it breaks down in the body into toxic substances. For headaches now they use a mix of Toradol (NSAID), anti nausea med (usually Zofran) and sometimes IV Benedryl. Does the same thing as Demerol for 1/2 the price, AND there are no opiates in any of them, so we can discharge patients faster. Answered by Larue Dalfonso 2 years ago.

The prescription of meperidine or demerol is for moderate to severe pain. If your pain is really really so bad that you can feel your head bursting open, the pain is even worse than getting your head smashed by a beer bottle you should go to your doctor again to explain the situation. Demerol has too many complication when taken. Answered by Lavonne Kurkowski 2 years ago.


How is Demerol administered--IV, IM, or both. About how much time before side effects would become apparent?
Also, what would be perhaps the initial side effects? Thank you Asked by Fawn Sarro 2 years ago.

Demerol can be given in pill form as well as IM or IV but usually the prescriptions are only given to patients in pill form for obvious reasons since shots & IV use are usually by medical personnel. With pill form usually the effect is felt in 30 minutes after pill dissolves.IV dose is felt within 1-2 minutes.IM dose is usually felt in 15-20 minutes (unless patient has other drugs in the system which may cause it to be earlier).Patients normally start to feel relaxed then say the pain starts to ease off.They often complain of being light headed & sleepy. Literature says the pain is relieved for 4 hours but in my experience patients start to complain of pain again in 3 hours.Demerol is really not a good drug for chronic pain management. Morphine lasts longer & easier to use in terminal patients.Demerol should only be used for short term patients & also not those mixing other opiates. Answered by Adele Reiter 2 years ago.

This Site Might Help You. RE: How is Demerol administered--IV, IM, or both. About how much time before side effects would become apparent? Also, what would be perhaps the initial side effects? Thank you Answered by Ninfa Dorian 2 years ago.

This I happen to know. Demerol can be administered either way. When administered IV, the drug takes effect immediately [depending on the strength] IM, about 15 min. 50mg to 100mg are the preferred dosage. Side effects include foggy brain, thick tongue and not being able to say "no", sexually speaking. I know this first hand. Enjoy the feeling. Answered by Renetta Sikula 2 years ago.


What does Demerol do? Is it as effective as an epidural?
Asked by Audrea Auricchio 2 years ago.

Demerol is a narcotic that will take the edge off of your pains and makes you feel a little elevated if you will!! It doesn't last that long, maybe an hour or 2 if your lucky and is best used towards the end of your labor as you are only allowed so many doses throughout your labor!! It is not nearly effective as an epidural because with the Demerol, you still feel your contractions, it just takes the edge off of it where as with the epidural, you are completely numb and can't feel anything until they lower your epidural medication!! Answered by Marlo Fruehauf 2 years ago.

demerol is a shot that is givenin the arm or hip sometimes given in an IV that is used to dull the pain and relax the mom so she can cope with the pain of contractions it's usually given every 2 to 4 hours.. it makes you feel drowsy it also sometimes causes nauses vomiting and a drop in blood pressure. and it sometimes does effect the babys breathing patterns and ability to suck right after delivery but the side effects wear off.. and epideral is administrated by a large needle into the epideral space of the spine. the needle will insert a small catheter into the space in which the medication will be released... this will numb your lower half of your body.. they can set the drip so you can feel some so your not completely numb to the experience.. from what i've read the only effect this can have on the baby is slowing the heart rate down on some... Answered by Alvin Steinruck 2 years ago.

No, all demerol does is make you feel more at ease..kinda high if you will. Epidural is a shot given to you in your back and it numbs your lower body. Answered by Olimpia Moochler 2 years ago.

No its not as effective as an epidural, demerol makes you groggy and less aware of the situation . epidural makes you numb but doesn't mess iwth your mind state. Answered by Jacques Mosho 2 years ago.

demerol is nothing like the epidural, opt for the epidural so u can at least be awake when you deliver. Answered by Sylvie Govia 2 years ago.

It makes you drowsy and unaware the epidural numbs from the waist down and doesnt make you drowsy in both births I had epidurals I waouldnt suggest the demoral but everyone is different Answered by Ryan Bushaw 2 years ago.

ive had demerol once, non pregnancy related...and im terribly allergic. Apparently. It gave me a really horrible rash, i had to get a shot to make it go away. it was all kinds of bad for me. Answered by Bobbie Kahanaoi 2 years ago.


How is Demerol made?
Asked by Particia Cuchares 2 years ago.

Isonicotinic Acid Methochloride. To a slurry of 246 g of isonicotinic acid in 3.2 liters of methanol and 300 ml of water containing 88 g of sodium hydroxide has 355 g of methyl iodide added to it. Note: Isonicotinic acid can be replaced with nicotinic acid, thus producing B-pethidine, instead of demerol. There is very little difference in potency between these two drugs and the formula does not change (just use an equimolar amount of nicotinic acid), so you may use either acid. Stir and reflux the above mixture for 60 hours, then remove the methanol with vacuo. Use sodium thiosulfate to reduce iodine to iodide and add water to give a volume of 1.5 liters. Use hydrochloric acid (concd) to get a ph of 2.0. Place a slurry of Amberlite IRA-400 (6.30 equivalents) in a glass tube 10 cm in diameter and 100 cm high. The resin is washed with 20 x 1. of 5% hydrochloric acid followed with 40 x 1. of distilled water. The yellow aqueous solution is passed through the column and the effluent, which had better be iodine free, is collected at a rate of flow of 50 ml per min. Three and one half liters of effluent is coned and the residue is dried and extracted with acetic acid. Xylene is added to the hot acetic acid solution, then cooled, and saturated with dry hydrogen chloride to give 336 g of crude product. Recrystallize from acetic acid to purify. 1-Methyl-4-carboxypiperidine Hydrochloride. Isonicotinic acid methochloride is quantitively reduced in a high pressure reaction vessel in the presence of platinum oxide in methanol at 1,000 psi, mp: 231-232°. 1-Methyl-4-chloro-4-benzoylpiperidine Hydrochloride. Chlorine gas is slowly passed (bubbled) into a solution of 48 g of the above product in 500 ml of glacial acetic acid for 8 hours at 70°. The volume is evaporated to 150 ml and 1 1iter of dry ether is added. The resulting white powder is recrystallized from chloroform, yielding 45 g of the hydrochloric salt, mp: 181° to 182°. This is then recrystallized from Skelly A, mp: 48-49°C. Rearrangement of 1-Mehtyl-4-chloro-4-benzoylpiperidine. Add 50 ml of xylene (containing 3.5 g of the above product) to a stirred refluxing solution containing 200 ml dry xylene and 18 g of finely powdered, dried sodium NaOH. Stir while refluxing for 30 min, then cool, extract with 25 ml portion of water until the ph of the extracts reaches neutrality (approximately). The combined water extracts are washed with three 25 ml portions of ether and adjusted to 8 ph with hydrochloric acid. The aqueous solution is concentrated to 50 ml (by evaporation in vacuo), filtered, and acidified to 6.5 with hydrochloric acid. The solution is cooled and the crystals are washed with water, acetone, ether, and then dried. Recrystallize from water to get fine, white needles of 1-methyl-4-phenyl-4-carboxy- piperidine. Yield: 0.8 g, mp: 309-310°. This product is then dissolved in ether and treated by passing dry hydrogen chloride through this solution and recrystallizing the resulting salt from acetic acid-benzene. Take the above hydrochloride salt and reflux it in ethanolic hydrogen chloride to get Demerol or analog. Now, you need to know that if you get it wrong, you may end up with a drug that causes irreversible Parkinsonism. If you use too much Demerol, there is a metabolite that will build up and knock off your kidneys. BTW, I left out a step. It's really not something an amateur can cook up. Answered by Michaela Carbonara 2 years ago.

What Is Demerol Made Of Answered by Julienne Doom 2 years ago.

Active Ingredient: Meperidine Hydrochloride Inactive Ingredients Tablets: Calcium Sulfate, Dibasic Calcium phosphate, Starch, Stearic Acid, Talc. Syrup: Benzoic Acid, Flavor, Liquid Glucose, Purified Water, Saccharin Sodium. Answered by Annika Fullwiler 2 years ago.

You dont feel the spinal cathedar once the med takes effect. It can only make labor go longer if there is a lot of meds and the woman cant feel anything, like no pressure. Doesnt matter the baby will come your body will push it out on its own if it had to. It lasts and wears off times differ per person and how often they push the little button to administer more medication. Every Dr and hospital are different some take it out if your going to push because they want you to feel the pressure, some dont mind if the partner is in the room as long as they stay out of the way of the anesthesiologist, but then some have policy that no one but the nurse and anesthesiologist can be in the room with the woman. Mine didnt work with any of my labors and deliveries, many women have epidurals and they work great, many women have them and they dont work at all. just know you did with out before and you were fine, you can do it, but I hope you are able to get a pain med if you want one, they do work wonderfully when they work, good luck~ Answered by Roland Krail 2 years ago.

Check out www.wikipedia.com and search for Pethidine. Find the basic ingredients for synthesis then using basic knowledge of synthetic organic chemistry, make some demerol. Oh and by the way, it is illegal to make unless you are a licensed pharmaceutical company. Its not as easy as making crack or meth...so stick to those. And for future reference, please don't ask questions on how to make drugs. Answered by Hortensia Fink 2 years ago.


Question about the drug demerol/pethidine..?
True John. But at least we know the heroin is being supplied on the black market, not administered illegally by rogue doctors. Asked by Christina Darbeau 2 years ago.

Demerol (pethidine/meperidine) is a synthetic opiate analgesic and it is a schedule II drug in The United States, Schedule I in Canada, and Class A in The UK. In just about any country Demerol would fall under the highest levels of control. But it is prescribed for patients all of the time. It is very commonly given (in hospital) for migraine that does not respond to other drugs. Some people doctor shop and get reasonable amount of narcotics from each doctor- but from 4 or 5 doctors and end up with a large amount of drugs. And there are very shady doctors out there who prescribe drugs as if it were nothing, sometimes because they are incompetent other times to satisfy a paying customer. And personal doctors are a bit more likely to doll out whatever the patient "needs." In many cases where The DEA revokes a doctors DEA number (required to give controlled substances) the doctor was giving out drugs in extreme excess. I know of one case where one doctor wrote 90 prescriptions for OxyContin to one person over 6 months or so. Also if you have a good relationship with your doctor and you have known each other for years and years then a doctor would probably be more amiable to prescribe any drug, but only to a point. Most doctors will not prescribe IV Demerol outside of a hospital/hospice. IV opiates are really only needed in emergency situations (morphine for heart attack) or for cancer, AIDS, and other conditions that can cause extreme pain. Answered by Jacqueline Henrey 2 years ago.

I'm not in California but all the states must follow the Federal laws governing narcotics. Demerol is strictly controlled but as in many celebrity situations there are doctors willing to bend the law to be near the limelight.Demerol is rarely used for pain & is given in tablet form by prescription only if other narcotics either don't work or a patient is allergic to codeine, oxycodone, and morphine (doctors better document this too for the Feds will yank their license if they find no records being kept...this applies in all narcotic prescriptions).Demerol is commonly used in hospitals for surgical patients & properly used short term only.It's not good for chronic use. In Hospice we almost never use Demerol for Morphine works much better for chronic pain as does Fentanyl. I've worked as a nurse for over 40 years and anytime someone asked for Demerol...they never got it and were looked on with suspicion for we knew they were addicts.I can truthfully say I've only seen prescriptions for Demerol for anyone outside the hospital setting maybe 6 times, mostly in tablet form & only 12 pills (dentists mostly post extraction).Celebrity Demerol isn't proper medicine. Answered by Tony Handford 2 years ago.

It's also strictly controlled in the US. If rumors are even vaguely close to true, then it wouldn't be surprising for MJ's physician to have hired an attorney at least in part because of a risk of losing his narcotic licensure, and perhaps even his license to practice medicine. On the other hand, there is no drug that can't be had by the wealthy or the determined. Certainly even heroin addiction is far from unknown in the UK! Answered by Audrea Gou 2 years ago.

I had an epidural last year and I was numb for a few hours after having my daughter. I had to have the nurses help me walk to the bathroom to take a bath. I dont think everyone is numb for hours I think it depends how long you have the epidural on for. I was in labor for 17 hours and I had the epidural for about 14 hours or so. Dont worry about it, after you give birth you may feel too tired to even get up so dont worry too much. You'll be fine! Answered by Scottie Bartlett 2 years ago.

Lestermount Answered by Travis Raner 2 years ago.


If Demerol is not supposed to used in treating long term pain management, how long would it be used for?
If Demerol is not safe for long term treatment of pain because of toxic buildup what would be the generally accepted period of time that it is safe to use? Would it be days, weeks, etc? The Michael Jackson case has sparked my curiosity. Thank you. Asked by Cathey Coreil 2 years ago.

Demerol is used for the treatment of chronic pain and acute pain. Many doctors prefer Demerol to other opiate analgesics due to some of its unique properties (but it falls more out of favour every year). However, some of its unique properties involving the reuptake of monoamine neurotransmitters (dopamine, serotonin, norepinephrine) and its almost cocaine like stimulation and anesthetic ability (cocaine is a local anesthetic) plus its very fast action makes it more addictive than other IV drugs, it has multiple major drug interactions, does not fully respond to opiate antagonists like Naloxone (for use in OD situations as an antidote), and it is actually toxic (a neurotoxin). One things opiates, especially naturally occurring and semisynthetic opiates, are known for are being "clean" drugs. This means that opiates like morphine do not interact with many neurotransmitters and receptors. So opiates have targeted action. Demerol acts with all sorts of neurotransmitters and has active metabolites that can damage the body. It is almost like morphine and cocaine mixed together hitting the brain in seconds after given IV. Thus it is far more addictive and has the potential for many problems (including cardiac). But it is not exactly a bad drug. Short term use is normally safe and people with certain medical conditions or who do not respond well to morphine and related drugs might use Demerol. It is available in tablet forms that people can take at home for pain. And it is very rare for IV Demerol to be needed except in hospital or home hospice. I can't imagine Jackson was in enough pain that he required daily shots of IV Demerol. Oral pain medication is typically effective in all but extreme situations. Answered by Shandi Dyment 2 years ago.

Toxic buildup is not the problem, addiction is. Demerol is a derivative of opium, similar to morphine. It is very effective as a pain killer, especially after a surgical procedure. Thus, it is almost ideal for short term use. For reasons that are not completely clear, some persons are more prone to addiction than others. Giving Demerol to these persons over an extended period of time is inadvisable. Many physicians are not astute as to the warning signs. Asking for repeated prescription refills is one huge red flag. Answered by Lauren Bardon 2 years ago.

It is physically addictive and your body begins to build a tolerance to opiates. Over a long period of time the patient will need larger and larger doses of Vicodin to relieve their pain. Answered by Lashanda Jeoffroy 2 years ago.


Does anyone know if there is a doctor that uses Demerol for pain?
I have a lot of headaches for over 40 year now. During my fifteenth year of these headaches I was sitting at work when my head thought it was going to blow apart, I have never in my life had a pain that felt like my brains were going to explode outward, I called my Dad and said :You've got to take me to the... Asked by Pamelia Ramthun 2 years ago.

I have a lot of headaches for over 40 year now. During my fifteenth year of these headaches I was sitting at work when my head thought it was going to blow apart, I have never in my life had a pain that felt like my brains were going to explode outward, I called my Dad and said :You've got to take me to the hospital ASAP as I think I am about to die,,,,and I really felt like i was going to die. I was saying my last prayers and I was crying eyes out over all the missed opportunity to do the things I should have done. Then I got to the ER and the doctor gave me a shot of 125 mg Demerol. My dad was in the room with me and I was complaining as to how much my head was still hurt,,,,,ing,,,,did I say HURT ng..........OMG .......it doesn.t hurt anymore...........I can't believe WHAT WAS THAT STUFF????? They told me it was called Demerol. This medicine took my 5 day headache away in 15 minutes. I want to know who has been hiding this stuff all this time. The ER's I go to tell they are using Dilaudid now and phasing out Demerol. That is sad, myself and many , many others believe that Demerol is the best headache medicine out there. If anyone knows which doctor would be willing to administer it, I would very very greatfull and thank you.Thank You and Thank You Answered by Clay Guterriez 2 years ago.

Demerol is still used although its use is in decline. Some hospitals have phased it out and it is not commonly prescribed out patient. Unlike other full opioid agonists (eg methadone, morphine, hydromorphone, oxymorphone) Demerol has a maximum dose, it is significantly neurotoxic and cardiotoxic in even modest doses or when taken too long, it tends to be more abused than other opioids (likely because it has opioid effects and it also has some pharmacological properties of cocaine). Demerol can only be taken for about two weeks at a time whereas most other opioids don't have a limit. I hear similar things from patients all the time. People with extremely severe headaches tend to respond extremely well to Demerol. In addition some consider Demerol to be the best drug to provide the most rapid and effective analgesia. Also hospitals try to avoid using opioids when a patients presents with a headache. However the reality is that opioids are extremely effective treatment to stop the pain once it starts and about 68% of the time opioids are used. People who only have occasional headaches are often prescribed opioids and/or barbiturates because they work so well. If you only have an occasional headache many doctors would likely be willing to prescribe a small number of Demerol tablets (in Canada there are 50 mg tabs and in America I believe there are 50 and 100 mg tabs). And doctors certainly do not administer IV Demerol except in hospital. You are just going to have to see a doctor about treatment. Other medications are something to consider. I will tell you that asking for Demerol and refusing to consider other treatment will make you look like a drug seeker. Answered by Reggie Touney 2 years ago.

Demerol Uses Answered by Sherley Kamal 2 years ago.

Yes, they are phasing out Demerol permanently because it breaks down in the body into toxic substances. For headaches now they use a mix of Toradol (NSAID), anti nausea med (usually Zofran) and sometimes IV Benedryl. Does the same thing as Demerol for 1/2 the price, AND there are no opiates in any of them, so we can discharge patients faster. Answered by Delsie Mcgrogan 2 years ago.

The prescription of meperidine or demerol is for moderate to severe pain. If your pain is really really so bad that you can feel your head bursting open, the pain is even worse than getting your head smashed by a beer bottle you should go to your doctor again to explain the situation. Demerol has too many complication when taken. Answered by Roberta Mcglinchey 2 years ago.


How is Demerol administered--IV, IM, or both. About how much time before side effects would become apparent?
Also, what would be perhaps the initial side effects? Thank you Asked by Susy Nyhus 2 years ago.

Demerol can be given in pill form as well as IM or IV but usually the prescriptions are only given to patients in pill form for obvious reasons since shots & IV use are usually by medical personnel. With pill form usually the effect is felt in 30 minutes after pill dissolves.IV dose is felt within 1-2 minutes.IM dose is usually felt in 15-20 minutes (unless patient has other drugs in the system which may cause it to be earlier).Patients normally start to feel relaxed then say the pain starts to ease off.They often complain of being light headed & sleepy. Literature says the pain is relieved for 4 hours but in my experience patients start to complain of pain again in 3 hours.Demerol is really not a good drug for chronic pain management. Morphine lasts longer & easier to use in terminal patients.Demerol should only be used for short term patients & also not those mixing other opiates. Answered by Arron Backstrom 2 years ago.

This Site Might Help You. RE: How is Demerol administered--IV, IM, or both. About how much time before side effects would become apparent? Also, what would be perhaps the initial side effects? Thank you Answered by Numbers Vongxay 2 years ago.

This I happen to know. Demerol can be administered either way. When administered IV, the drug takes effect immediately [depending on the strength] IM, about 15 min. 50mg to 100mg are the preferred dosage. Side effects include foggy brain, thick tongue and not being able to say "no", sexually speaking. I know this first hand. Enjoy the feeling. Answered by Jessie Ryherd 2 years ago.


What does Demerol do? Is it as effective as an epidural?
Asked by Marianela Teder 2 years ago.

Demerol is a narcotic that will take the edge off of your pains and makes you feel a little elevated if you will!! It doesn't last that long, maybe an hour or 2 if your lucky and is best used towards the end of your labor as you are only allowed so many doses throughout your labor!! It is not nearly effective as an epidural because with the Demerol, you still feel your contractions, it just takes the edge off of it where as with the epidural, you are completely numb and can't feel anything until they lower your epidural medication!! Answered by Perry Pfanstiel 2 years ago.

demerol is a shot that is givenin the arm or hip sometimes given in an IV that is used to dull the pain and relax the mom so she can cope with the pain of contractions it's usually given every 2 to 4 hours.. it makes you feel drowsy it also sometimes causes nauses vomiting and a drop in blood pressure. and it sometimes does effect the babys breathing patterns and ability to suck right after delivery but the side effects wear off.. and epideral is administrated by a large needle into the epideral space of the spine. the needle will insert a small catheter into the space in which the medication will be released... this will numb your lower half of your body.. they can set the drip so you can feel some so your not completely numb to the experience.. from what i've read the only effect this can have on the baby is slowing the heart rate down on some... Answered by Evette Krofta 2 years ago.

No, all demerol does is make you feel more at ease..kinda high if you will. Epidural is a shot given to you in your back and it numbs your lower body. Answered by Johnetta Diepenbrock 2 years ago.

No its not as effective as an epidural, demerol makes you groggy and less aware of the situation . epidural makes you numb but doesn't mess iwth your mind state. Answered by Candi Flaminio 2 years ago.

demerol is nothing like the epidural, opt for the epidural so u can at least be awake when you deliver. Answered by Hellen Anetsberger 2 years ago.

It makes you drowsy and unaware the epidural numbs from the waist down and doesnt make you drowsy in both births I had epidurals I waouldnt suggest the demoral but everyone is different Answered by Antionette Kitzrow 2 years ago.

ive had demerol once, non pregnancy related...and im terribly allergic. Apparently. It gave me a really horrible rash, i had to get a shot to make it go away. it was all kinds of bad for me. Answered by Belia Gronosky 2 years ago.


How is Demerol made?
Asked by Nikki Aumend 2 years ago.

Isonicotinic Acid Methochloride. To a slurry of 246 g of isonicotinic acid in 3.2 liters of methanol and 300 ml of water containing 88 g of sodium hydroxide has 355 g of methyl iodide added to it. Note: Isonicotinic acid can be replaced with nicotinic acid, thus producing B-pethidine, instead of demerol. There is very little difference in potency between these two drugs and the formula does not change (just use an equimolar amount of nicotinic acid), so you may use either acid. Stir and reflux the above mixture for 60 hours, then remove the methanol with vacuo. Use sodium thiosulfate to reduce iodine to iodide and add water to give a volume of 1.5 liters. Use hydrochloric acid (concd) to get a ph of 2.0. Place a slurry of Amberlite IRA-400 (6.30 equivalents) in a glass tube 10 cm in diameter and 100 cm high. The resin is washed with 20 x 1. of 5% hydrochloric acid followed with 40 x 1. of distilled water. The yellow aqueous solution is passed through the column and the effluent, which had better be iodine free, is collected at a rate of flow of 50 ml per min. Three and one half liters of effluent is coned and the residue is dried and extracted with acetic acid. Xylene is added to the hot acetic acid solution, then cooled, and saturated with dry hydrogen chloride to give 336 g of crude product. Recrystallize from acetic acid to purify. 1-Methyl-4-carboxypiperidine Hydrochloride. Isonicotinic acid methochloride is quantitively reduced in a high pressure reaction vessel in the presence of platinum oxide in methanol at 1,000 psi, mp: 231-232°. 1-Methyl-4-chloro-4-benzoylpiperidine Hydrochloride. Chlorine gas is slowly passed (bubbled) into a solution of 48 g of the above product in 500 ml of glacial acetic acid for 8 hours at 70°. The volume is evaporated to 150 ml and 1 1iter of dry ether is added. The resulting white powder is recrystallized from chloroform, yielding 45 g of the hydrochloric salt, mp: 181° to 182°. This is then recrystallized from Skelly A, mp: 48-49°C. Rearrangement of 1-Mehtyl-4-chloro-4-benzoylpiperidine. Add 50 ml of xylene (containing 3.5 g of the above product) to a stirred refluxing solution containing 200 ml dry xylene and 18 g of finely powdered, dried sodium NaOH. Stir while refluxing for 30 min, then cool, extract with 25 ml portion of water until the ph of the extracts reaches neutrality (approximately). The combined water extracts are washed with three 25 ml portions of ether and adjusted to 8 ph with hydrochloric acid. The aqueous solution is concentrated to 50 ml (by evaporation in vacuo), filtered, and acidified to 6.5 with hydrochloric acid. The solution is cooled and the crystals are washed with water, acetone, ether, and then dried. Recrystallize from water to get fine, white needles of 1-methyl-4-phenyl-4-carboxy- piperidine. Yield: 0.8 g, mp: 309-310°. This product is then dissolved in ether and treated by passing dry hydrogen chloride through this solution and recrystallizing the resulting salt from acetic acid-benzene. Take the above hydrochloride salt and reflux it in ethanolic hydrogen chloride to get Demerol or analog. Now, you need to know that if you get it wrong, you may end up with a drug that causes irreversible Parkinsonism. If you use too much Demerol, there is a metabolite that will build up and knock off your kidneys. BTW, I left out a step. It's really not something an amateur can cook up. Answered by Jacinda Royce 2 years ago.

What Is Demerol Made Of Answered by Felix Spika 2 years ago.

Active Ingredient: Meperidine Hydrochloride Inactive Ingredients Tablets: Calcium Sulfate, Dibasic Calcium phosphate, Starch, Stearic Acid, Talc. Syrup: Benzoic Acid, Flavor, Liquid Glucose, Purified Water, Saccharin Sodium. Answered by Stephany Krell 2 years ago.

You dont feel the spinal cathedar once the med takes effect. It can only make labor go longer if there is a lot of meds and the woman cant feel anything, like no pressure. Doesnt matter the baby will come your body will push it out on its own if it had to. It lasts and wears off times differ per person and how often they push the little button to administer more medication. Every Dr and hospital are different some take it out if your going to push because they want you to feel the pressure, some dont mind if the partner is in the room as long as they stay out of the way of the anesthesiologist, but then some have policy that no one but the nurse and anesthesiologist can be in the room with the woman. Mine didnt work with any of my labors and deliveries, many women have epidurals and they work great, many women have them and they dont work at all. just know you did with out before and you were fine, you can do it, but I hope you are able to get a pain med if you want one, they do work wonderfully when they work, good luck~ Answered by Elba Astin 2 years ago.

Check out www.wikipedia.com and search for Pethidine. Find the basic ingredients for synthesis then using basic knowledge of synthetic organic chemistry, make some demerol. Oh and by the way, it is illegal to make unless you are a licensed pharmaceutical company. Its not as easy as making crack or meth...so stick to those. And for future reference, please don't ask questions on how to make drugs. Answered by Eden Hoelscher 2 years ago.


Question about the drug demerol/pethidine..?
True John. But at least we know the heroin is being supplied on the black market, not administered illegally by rogue doctors. Asked by Fe Krakowiak 2 years ago.

Demerol (pethidine/meperidine) is a synthetic opiate analgesic and it is a schedule II drug in The United States, Schedule I in Canada, and Class A in The UK. In just about any country Demerol would fall under the highest levels of control. But it is prescribed for patients all of the time. It is very commonly given (in hospital) for migraine that does not respond to other drugs. Some people doctor shop and get reasonable amount of narcotics from each doctor- but from 4 or 5 doctors and end up with a large amount of drugs. And there are very shady doctors out there who prescribe drugs as if it were nothing, sometimes because they are incompetent other times to satisfy a paying customer. And personal doctors are a bit more likely to doll out whatever the patient "needs." In many cases where The DEA revokes a doctors DEA number (required to give controlled substances) the doctor was giving out drugs in extreme excess. I know of one case where one doctor wrote 90 prescriptions for OxyContin to one person over 6 months or so. Also if you have a good relationship with your doctor and you have known each other for years and years then a doctor would probably be more amiable to prescribe any drug, but only to a point. Most doctors will not prescribe IV Demerol outside of a hospital/hospice. IV opiates are really only needed in emergency situations (morphine for heart attack) or for cancer, AIDS, and other conditions that can cause extreme pain. Answered by Sirena Leib 2 years ago.

I'm not in California but all the states must follow the Federal laws governing narcotics. Demerol is strictly controlled but as in many celebrity situations there are doctors willing to bend the law to be near the limelight.Demerol is rarely used for pain & is given in tablet form by prescription only if other narcotics either don't work or a patient is allergic to codeine, oxycodone, and morphine (doctors better document this too for the Feds will yank their license if they find no records being kept...this applies in all narcotic prescriptions).Demerol is commonly used in hospitals for surgical patients & properly used short term only.It's not good for chronic use. In Hospice we almost never use Demerol for Morphine works much better for chronic pain as does Fentanyl. I've worked as a nurse for over 40 years and anytime someone asked for Demerol...they never got it and were looked on with suspicion for we knew they were addicts.I can truthfully say I've only seen prescriptions for Demerol for anyone outside the hospital setting maybe 6 times, mostly in tablet form & only 12 pills (dentists mostly post extraction).Celebrity Demerol isn't proper medicine. Answered by Kellie Infantino 2 years ago.

It's also strictly controlled in the US. If rumors are even vaguely close to true, then it wouldn't be surprising for MJ's physician to have hired an attorney at least in part because of a risk of losing his narcotic licensure, and perhaps even his license to practice medicine. On the other hand, there is no drug that can't be had by the wealthy or the determined. Certainly even heroin addiction is far from unknown in the UK! Answered by Grayce Kyler 2 years ago.

I had an epidural last year and I was numb for a few hours after having my daughter. I had to have the nurses help me walk to the bathroom to take a bath. I dont think everyone is numb for hours I think it depends how long you have the epidural on for. I was in labor for 17 hours and I had the epidural for about 14 hours or so. Dont worry about it, after you give birth you may feel too tired to even get up so dont worry too much. You'll be fine! Answered by Kiara Rohe 2 years ago.

Lestermount Answered by Miesha Ciborowski 2 years ago.


If Demerol is not supposed to used in treating long term pain management, how long would it be used for?
If Demerol is not safe for long term treatment of pain because of toxic buildup what would be the generally accepted period of time that it is safe to use? Would it be days, weeks, etc? The Michael Jackson case has sparked my curiosity. Thank you. Asked by Earle Moretz 2 years ago.

Demerol is used for the treatment of chronic pain and acute pain. Many doctors prefer Demerol to other opiate analgesics due to some of its unique properties (but it falls more out of favour every year). However, some of its unique properties involving the reuptake of monoamine neurotransmitters (dopamine, serotonin, norepinephrine) and its almost cocaine like stimulation and anesthetic ability (cocaine is a local anesthetic) plus its very fast action makes it more addictive than other IV drugs, it has multiple major drug interactions, does not fully respond to opiate antagonists like Naloxone (for use in OD situations as an antidote), and it is actually toxic (a neurotoxin). One things opiates, especially naturally occurring and semisynthetic opiates, are known for are being "clean" drugs. This means that opiates like morphine do not interact with many neurotransmitters and receptors. So opiates have targeted action. Demerol acts with all sorts of neurotransmitters and has active metabolites that can damage the body. It is almost like morphine and cocaine mixed together hitting the brain in seconds after given IV. Thus it is far more addictive and has the potential for many problems (including cardiac). But it is not exactly a bad drug. Short term use is normally safe and people with certain medical conditions or who do not respond well to morphine and related drugs might use Demerol. It is available in tablet forms that people can take at home for pain. And it is very rare for IV Demerol to be needed except in hospital or home hospice. I can't imagine Jackson was in enough pain that he required daily shots of IV Demerol. Oral pain medication is typically effective in all but extreme situations. Answered by Etsuko Gwynes 2 years ago.

Toxic buildup is not the problem, addiction is. Demerol is a derivative of opium, similar to morphine. It is very effective as a pain killer, especially after a surgical procedure. Thus, it is almost ideal for short term use. For reasons that are not completely clear, some persons are more prone to addiction than others. Giving Demerol to these persons over an extended period of time is inadvisable. Many physicians are not astute as to the warning signs. Asking for repeated prescription refills is one huge red flag. Answered by Clint Nanez 2 years ago.

It is physically addictive and your body begins to build a tolerance to opiates. Over a long period of time the patient will need larger and larger doses of Vicodin to relieve their pain. Answered by Haywood Timson 2 years ago.


Does anyone know if there is a doctor that uses Demerol for pain?
I have a lot of headaches for over 40 year now. During my fifteenth year of these headaches I was sitting at work when my head thought it was going to blow apart, I have never in my life had a pain that felt like my brains were going to explode outward, I called my Dad and said :You've got to take me to the... Asked by Dorla Erven 2 years ago.

I have a lot of headaches for over 40 year now. During my fifteenth year of these headaches I was sitting at work when my head thought it was going to blow apart, I have never in my life had a pain that felt like my brains were going to explode outward, I called my Dad and said :You've got to take me to the hospital ASAP as I think I am about to die,,,,and I really felt like i was going to die. I was saying my last prayers and I was crying eyes out over all the missed opportunity to do the things I should have done. Then I got to the ER and the doctor gave me a shot of 125 mg Demerol. My dad was in the room with me and I was complaining as to how much my head was still hurt,,,,,ing,,,,did I say HURT ng..........OMG .......it doesn.t hurt anymore...........I can't believe WHAT WAS THAT STUFF????? They told me it was called Demerol. This medicine took my 5 day headache away in 15 minutes. I want to know who has been hiding this stuff all this time. The ER's I go to tell they are using Dilaudid now and phasing out Demerol. That is sad, myself and many , many others believe that Demerol is the best headache medicine out there. If anyone knows which doctor would be willing to administer it, I would very very greatfull and thank you.Thank You and Thank You Answered by Beverley Ciucci 2 years ago.

Demerol is still used although its use is in decline. Some hospitals have phased it out and it is not commonly prescribed out patient. Unlike other full opioid agonists (eg methadone, morphine, hydromorphone, oxymorphone) Demerol has a maximum dose, it is significantly neurotoxic and cardiotoxic in even modest doses or when taken too long, it tends to be more abused than other opioids (likely because it has opioid effects and it also has some pharmacological properties of cocaine). Demerol can only be taken for about two weeks at a time whereas most other opioids don't have a limit. I hear similar things from patients all the time. People with extremely severe headaches tend to respond extremely well to Demerol. In addition some consider Demerol to be the best drug to provide the most rapid and effective analgesia. Also hospitals try to avoid using opioids when a patients presents with a headache. However the reality is that opioids are extremely effective treatment to stop the pain once it starts and about 68% of the time opioids are used. People who only have occasional headaches are often prescribed opioids and/or barbiturates because they work so well. If you only have an occasional headache many doctors would likely be willing to prescribe a small number of Demerol tablets (in Canada there are 50 mg tabs and in America I believe there are 50 and 100 mg tabs). And doctors certainly do not administer IV Demerol except in hospital. You are just going to have to see a doctor about treatment. Other medications are something to consider. I will tell you that asking for Demerol and refusing to consider other treatment will make you look like a drug seeker. Answered by Latosha Gothe 2 years ago.

Demerol Uses Answered by Alisa Prugh 2 years ago.

Yes, they are phasing out Demerol permanently because it breaks down in the body into toxic substances. For headaches now they use a mix of Toradol (NSAID), anti nausea med (usually Zofran) and sometimes IV Benedryl. Does the same thing as Demerol for 1/2 the price, AND there are no opiates in any of them, so we can discharge patients faster. Answered by Teddy Wolff 2 years ago.

The prescription of meperidine or demerol is for moderate to severe pain. If your pain is really really so bad that you can feel your head bursting open, the pain is even worse than getting your head smashed by a beer bottle you should go to your doctor again to explain the situation. Demerol has too many complication when taken. Answered by Samuel Mcaleese 2 years ago.


How is Demerol administered--IV, IM, or both. About how much time before side effects would become apparent?
Also, what would be perhaps the initial side effects? Thank you Asked by Ruth Barretto 2 years ago.

Demerol can be given in pill form as well as IM or IV but usually the prescriptions are only given to patients in pill form for obvious reasons since shots & IV use are usually by medical personnel. With pill form usually the effect is felt in 30 minutes after pill dissolves.IV dose is felt within 1-2 minutes.IM dose is usually felt in 15-20 minutes (unless patient has other drugs in the system which may cause it to be earlier).Patients normally start to feel relaxed then say the pain starts to ease off.They often complain of being light headed & sleepy. Literature says the pain is relieved for 4 hours but in my experience patients start to complain of pain again in 3 hours.Demerol is really not a good drug for chronic pain management. Morphine lasts longer & easier to use in terminal patients.Demerol should only be used for short term patients & also not those mixing other opiates. Answered by Bridget Estel 2 years ago.

This Site Might Help You. RE: How is Demerol administered--IV, IM, or both. About how much time before side effects would become apparent? Also, what would be perhaps the initial side effects? Thank you Answered by Joel Tweedy 2 years ago.

This I happen to know. Demerol can be administered either way. When administered IV, the drug takes effect immediately [depending on the strength] IM, about 15 min. 50mg to 100mg are the preferred dosage. Side effects include foggy brain, thick tongue and not being able to say "no", sexually speaking. I know this first hand. Enjoy the feeling. Answered by Leah Uyemura 2 years ago.


What does Demerol do? Is it as effective as an epidural?
Asked by Mathilde Cornelison 2 years ago.

Demerol is a narcotic that will take the edge off of your pains and makes you feel a little elevated if you will!! It doesn't last that long, maybe an hour or 2 if your lucky and is best used towards the end of your labor as you are only allowed so many doses throughout your labor!! It is not nearly effective as an epidural because with the Demerol, you still feel your contractions, it just takes the edge off of it where as with the epidural, you are completely numb and can't feel anything until they lower your epidural medication!! Answered by Anabel Monceaux 2 years ago.

demerol is a shot that is givenin the arm or hip sometimes given in an IV that is used to dull the pain and relax the mom so she can cope with the pain of contractions it's usually given every 2 to 4 hours.. it makes you feel drowsy it also sometimes causes nauses vomiting and a drop in blood pressure. and it sometimes does effect the babys breathing patterns and ability to suck right after delivery but the side effects wear off.. and epideral is administrated by a large needle into the epideral space of the spine. the needle will insert a small catheter into the space in which the medication will be released... this will numb your lower half of your body.. they can set the drip so you can feel some so your not completely numb to the experience.. from what i've read the only effect this can have on the baby is slowing the heart rate down on some... Answered by Emma Jovich 2 years ago.

No, all demerol does is make you feel more at ease..kinda high if you will. Epidural is a shot given to you in your back and it numbs your lower body. Answered by Amparo Pevahouse 2 years ago.

No its not as effective as an epidural, demerol makes you groggy and less aware of the situation . epidural makes you numb but doesn't mess iwth your mind state. Answered by Ray Schwerin 2 years ago.

demerol is nothing like the epidural, opt for the epidural so u can at least be awake when you deliver. Answered by Sherlene Dziewanowski 2 years ago.

It makes you drowsy and unaware the epidural numbs from the waist down and doesnt make you drowsy in both births I had epidurals I waouldnt suggest the demoral but everyone is different Answered by Roslyn Seiger 2 years ago.

ive had demerol once, non pregnancy related...and im terribly allergic. Apparently. It gave me a really horrible rash, i had to get a shot to make it go away. it was all kinds of bad for me. Answered by Estrella Morrin 2 years ago.


How is Demerol made?
Asked by Daisy Smithheart 2 years ago.

Isonicotinic Acid Methochloride. To a slurry of 246 g of isonicotinic acid in 3.2 liters of methanol and 300 ml of water containing 88 g of sodium hydroxide has 355 g of methyl iodide added to it. Note: Isonicotinic acid can be replaced with nicotinic acid, thus producing B-pethidine, instead of demerol. There is very little difference in potency between these two drugs and the formula does not change (just use an equimolar amount of nicotinic acid), so you may use either acid. Stir and reflux the above mixture for 60 hours, then remove the methanol with vacuo. Use sodium thiosulfate to reduce iodine to iodide and add water to give a volume of 1.5 liters. Use hydrochloric acid (concd) to get a ph of 2.0. Place a slurry of Amberlite IRA-400 (6.30 equivalents) in a glass tube 10 cm in diameter and 100 cm high. The resin is washed with 20 x 1. of 5% hydrochloric acid followed with 40 x 1. of distilled water. The yellow aqueous solution is passed through the column and the effluent, which had better be iodine free, is collected at a rate of flow of 50 ml per min. Three and one half liters of effluent is coned and the residue is dried and extracted with acetic acid. Xylene is added to the hot acetic acid solution, then cooled, and saturated with dry hydrogen chloride to give 336 g of crude product. Recrystallize from acetic acid to purify. 1-Methyl-4-carboxypiperidine Hydrochloride. Isonicotinic acid methochloride is quantitively reduced in a high pressure reaction vessel in the presence of platinum oxide in methanol at 1,000 psi, mp: 231-232°. 1-Methyl-4-chloro-4-benzoylpiperidine Hydrochloride. Chlorine gas is slowly passed (bubbled) into a solution of 48 g of the above product in 500 ml of glacial acetic acid for 8 hours at 70°. The volume is evaporated to 150 ml and 1 1iter of dry ether is added. The resulting white powder is recrystallized from chloroform, yielding 45 g of the hydrochloric salt, mp: 181° to 182°. This is then recrystallized from Skelly A, mp: 48-49°C. Rearrangement of 1-Mehtyl-4-chloro-4-benzoylpiperidine. Add 50 ml of xylene (containing 3.5 g of the above product) to a stirred refluxing solution containing 200 ml dry xylene and 18 g of finely powdered, dried sodium NaOH. Stir while refluxing for 30 min, then cool, extract with 25 ml portion of water until the ph of the extracts reaches neutrality (approximately). The combined water extracts are washed with three 25 ml portions of ether and adjusted to 8 ph with hydrochloric acid. The aqueous solution is concentrated to 50 ml (by evaporation in vacuo), filtered, and acidified to 6.5 with hydrochloric acid. The solution is cooled and the crystals are washed with water, acetone, ether, and then dried. Recrystallize from water to get fine, white needles of 1-methyl-4-phenyl-4-carboxy- piperidine. Yield: 0.8 g, mp: 309-310°. This product is then dissolved in ether and treated by passing dry hydrogen chloride through this solution and recrystallizing the resulting salt from acetic acid-benzene. Take the above hydrochloride salt and reflux it in ethanolic hydrogen chloride to get Demerol or analog. Now, you need to know that if you get it wrong, you may end up with a drug that causes irreversible Parkinsonism. If you use too much Demerol, there is a metabolite that will build up and knock off your kidneys. BTW, I left out a step. It's really not something an amateur can cook up. Answered by Vashti Bargo 2 years ago.

What Is Demerol Made Of Answered by Jonas Gridley 2 years ago.

Active Ingredient: Meperidine Hydrochloride Inactive Ingredients Tablets: Calcium Sulfate, Dibasic Calcium phosphate, Starch, Stearic Acid, Talc. Syrup: Benzoic Acid, Flavor, Liquid Glucose, Purified Water, Saccharin Sodium. Answered by Aletha Ailey 2 years ago.

You dont feel the spinal cathedar once the med takes effect. It can only make labor go longer if there is a lot of meds and the woman cant feel anything, like no pressure. Doesnt matter the baby will come your body will push it out on its own if it had to. It lasts and wears off times differ per person and how often they push the little button to administer more medication. Every Dr and hospital are different some take it out if your going to push because they want you to feel the pressure, some dont mind if the partner is in the room as long as they stay out of the way of the anesthesiologist, but then some have policy that no one but the nurse and anesthesiologist can be in the room with the woman. Mine didnt work with any of my labors and deliveries, many women have epidurals and they work great, many women have them and they dont work at all. just know you did with out before and you were fine, you can do it, but I hope you are able to get a pain med if you want one, they do work wonderfully when they work, good luck~ Answered by Nicolas Councill 2 years ago.

Check out www.wikipedia.com and search for Pethidine. Find the basic ingredients for synthesis then using basic knowledge of synthetic organic chemistry, make some demerol. Oh and by the way, it is illegal to make unless you are a licensed pharmaceutical company. Its not as easy as making crack or meth...so stick to those. And for future reference, please don't ask questions on how to make drugs. Answered by Brendan Derosby 2 years ago.


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