DASATINIB Ressources

Application Information

This drug has been submitted to the FDA under the reference 202103/001.

Names and composition

"DASATINIB" is the commercial name of a drug composed of DASATINIB.
It belongs to the class Protein kinase inhibitors and is used in Antineoplastics (Cancer)

Answered questions

What are the drug trials/treatments suggested for dasatinib resistant CML or CML with T315I mutation?
Asked by Corine Strackbein 5 months ago.

Dasatinib is a new, oral small-molecule tyrosine kinase inhibitor (TKI) developed by Bristol Myers Squibb for the treatment of CML. Although still in relatively early-stage development, both the US FDA and European EMEA have granted accelerated approval for the use of dasatinib in adult patients with CML (all stages) that are resistant or intolerant to prior therapy, including treatment with imatinib mesylate. In addition, approval has been given for its use in the treatment of Philadelphia chromosome-positive acute lymphoblastic leukaemia in adult patients resistant or intolerant to prior therapy. Dasatinib, which will be marketed under the brand name Sprycel, was designated an orphan medicinal product at the end of 2005. CHROMOSOMAL TRANSLOCATION IN CML CML, one of the most common forms of leukaemia, arises from the excessive production of abnormal stem cells in the bone marrow, which eventually suppress the production of normal white blood cells. The disease usually has three identifiable phases: the initial chronic phase, which is typically benign and lasts for an average three to five years from diagnosis, the accelerated phase and finally the blast-crisis phase.- Answered by Raymonde Kelsheimer 5 months ago.

I assume Gleevec (imatinib) was intolerable or unresponsive. The second line therapy is Sprycel (dasatinib). There is another tyrosine kinase inhibitor pretty far along into clinical trials, AMN-107 (nilotinib). Preliminary results are very encouraging. It is not approved yet for use but, you can try to get it by enrolling in a clinical trial. MD Anderson seems to be one of the top cancer centers in the World for this type of cancer (and many other types). After that, there are the old treatment options of interferon, chemotherapy and, a BMT. Answered by Hilda Michelfelder 5 months ago.

What about Gleevec? I thought that was the drug of choice anyway. Answered by Tomeka Kowalchick 5 months ago.

Adding 2 more chemos (dasatinib and carboplatin) to the mix, likely to work? Will I notice?
Cheers BSherman, and good work on calling out my error in judgement =) Asked by Wesley Bake 5 months ago.

I'm on ifosfamide and etoposide and now we're adding dasatinib and carboplatin. Any evidence that the new drugs will make a difference? Will they work on bone/lung mets? Are they super toxic? I guess I'm wondering why I wasn't given them at first, if they think they might work now... My primary cancer is a bone cancer (osteosarcoma) Answered by Eulah Francey 5 months ago.

My small cell carcinoma was treated with first surgery then Carboplaten & Etoposide im combination. My side effects were nowhere near as bad as i had been led to expect. Hair loss, some lethargy, mild indigestion, that was about it. Your oncologist is the best person to give you information. Answered by Judi Alapai 5 months ago.

Oncologists base individualized treatment plans upon historical outcomes for patients with similar conditions. Oncologists all over the world have access to continuously updated clinical information on the effectiveness of various chemotherapy protocols. Your oncologist will first select the combination and dosage of drugs expected to give you the best result based upon the primary site, stage, and special characteristics of your disease. Your overall health and how well you respond to initial treatment (does it shrink the tumor) determines next steps. How patients respond to initial treatment often results in adjustment of drugs and/or dosage. It sounds like your doctor tried the internationally recommended drug protocol for your disease status, evaluated how well that worked, and is now making adjustments with the goal of improving results. Your oncologist's action do not mean that he thought the new drugs didn't work before, but will now. That is an erroneous supposition. Please give your doctor more credit than that. He is trying to help you and will do his utmost. Best wishes for better days ahead. Answered by Jefferey Millar 5 months ago.

Cannot really say coz were different condition. Dasatinib gives me headaches and cramps but is effective compared to other drugs i took. Answered by Eliza Expose 5 months ago.

Is there any relief from the chills associated with Dasatinib{Sprycell} or Imatinib{Gleevec}?
Currently Sprycell for 22 months. Cannot tolerate anymore. Previously same experience with Gleevec{24 months} Asked by Maile Hakes 5 months ago.

Well, depending on your disease condition, you can talk to your henatologist/oncologist about lowering your dose. If you're doing pretty well as is, reducing your dose may not have a very, or even slightly, negative impact on your treatment. As you know, there's really only one other drug in the modern CML line up, so you want to try to hang on to each medication you're using as long as is feasible. Answered by Latrice Meglio 5 months ago.

Can you do Shrooms while on Chemo?
Hi, I was just wondering, not that I would ever do this, but I am currently taking a chemotherapy called Dasatinib and I was just wondering if you take shrooms while on this drug, will it have any effect? Could it kill you? Reverse the stability process of the chemo? Just wanted to know, thanks. Asked by Jackqueline Stonecypher 5 months ago.

I see no evidence that psilocybin interacts badly with this drug. You should be ok to take mushrooms. Answered by Lorine Riese 5 months ago.

Consult with your oncologist. Ask your oncologist if using toxic, illegal drugs is a good idea for cancer patients. Drug interactions may decrease or negate the effectiveness of your chemotherapy. Furthermore, toxic substances may overwhelm your already compromised organ functions. Serious organ damage or death are possible. Answered by Shantell Papenfuss 5 months ago.

Relapse ALL after BMT,?
My son was relapsed after BMT, he has Ph1 ALL, the count of leukemic cell in his Bone marrow is 91% now and the BCR/ABL is 1.7*10e5, he is now on chemotherapy with dasatinib 80mg/day, all other body function is almost normal but the medical staff here did was not able to use some new drugs because of the law and... Asked by Larraine Berwald 5 months ago.

My son was relapsed after BMT, he has Ph1 ALL, the count of leukemic cell in his Bone marrow is 91% now and the BCR/ABL is 1.7*10e5, he is now on chemotherapy with dasatinib 80mg/day, all other body function is almost normal but the medical staff here did was not able to use some new drugs because of the law and asked me to seek another country. Is there a new treatment for his caseand how can i contact other medical staff Answered by Rheba Cobler 5 months ago.

Have you tried St.Judes? I went there from 14 - 16 because I stopped responding to treatment.I started improving came back to my hometown but here they said it's too far a long and I stopped responding again.. They are a great children's hospital dealing with cancers in just kids. Good Luck! Answered by Justin Nemec 5 months ago.

Anybody who knows cases with chronic leukemia? Is this curable? Any idea with the life span?
Asked by Junko Blye 5 months ago.

Chronic lymphocytic leukemia (or "chronic lymphoid leukemia"), known for short as CLL, is a type of leukemia in which too many lymphocytes are produced. Although the malignant lymphocytes in CLL may look normal and mature, they are not and these cells may not cope effectively with infection. CLL is the most common form of leukemia in adults. Men are twice as likely to develop CLL as women. However, the key risk factor is age. Over 75% of new cases are diagnosed in patients over age 50. More than 7,000 new cases of CLL are diagnosed in the U.S. each year. Whilst generally considered incurable CLL progresses slowly in most cases. Many people with CLL lead normal and active lives for many years - in some cases for decades. Because of its slow onset, early-stage CLL is generally not treated since it is believed that early CLL intervention does not improve survival time or quality of life. Instead, the condition is monitored over time. Chronic myelogenous leukemia (CML) is a form of chronic leukemia characterized by increased and unregulated clonal production of predominantly myeloid cells in the bone marrow. CML is a myeloproliferative disease associated with a characteristic chromosomal translocation called the Philadelphia chromosome. Historically, it has been treated with chemotherapy, interferon and bone marrow transplantation, although targeted therapies introduced at the beginning of the 21st century have radically changed the management of CML. Chronic phase Chronic phase CML is treated with imatinib mesylate (marketed as Gleevec® or Glivec®; previously known as STI-571). In the past, antimetabolites (e.g. cytarabine, hydroxyurea), alkylating agents, interferon alfa 2b, and steroids were used, but this has been replaced by imatinib. Imatinib is a new agent, approved by the US FDA in 2001, which specifically targets BCR/abl, the constitutively activated tyrosine kinase fusion protein caused by the Philadelphia chromosome translocation that is felt to be responsible for driving the abnormal cell proliferation of CML. It is better tolerated and more effective than previous therapies. Bone marrow transplantation was also used as initial treatment for CML in younger patients before the advent of imatinib, and while it can often be curative, there is a high rate of transplant-related mortality. Another new drug, dasatinib (marketed as Sprycel®; previously known as BMS-354825), which has a similar mechanism of action to imatinib but inhibiting a broader spectrum of tyrosine kinases, was approved by the U.S. FDA in June 2006 for use in patients with CML who are no longer responding to, or who can no longer tolerate, therapy with imatinib. [1] Pre-clinical research indicates that the anti-leukemic effect of dasatinib may be further enhanced by the addition of a small molecular inhibitor known as PD184352 [2] Various combinations of the different treatment modalities are being explored. In 2005 favourable results of vaccination were reported with the BCR/abl p210 fusion protein in patients with stable disease, with GM-CSF as an adjuvant.[8] Two other drugs, ceflatonin (homoharringtonine) and nilotinib (AMN 107) are currently in active clinical trials in patients with CML who have developed resistance to imatinib. [3]. [edit] Blast crisis Blast crisis carries all the symptoms and characteristics of either acute myelogenous leukemia or acute lymphoblastic leukemia, and has a very high mortality rate. This stage can most effectively be treated by a bone marrow transplant after high-dose chemotherapy. In young patients in the accelerated phase, a transplant may also be an option. However the likelihood of relapse after a bone marrow transplant is higher in patients in blast crisis or in the accelerated phase as compared to patients in the chronic phase. Answered by Victor Greising 5 months ago.

Chronic leukemia is sometimes misdiagnosed and is some other type of cancer. if you are for sure that is what you have then your doctor can give you more accurate information on curability or somewhat life span. Today many ppl live long with treatment even if not cureable. That in itself a great. Remember nobody gets out of life a live. We just have to hope for a good quality of life and live everyday and enjoy ourselves.. Answered by Maryanna Geoffrey 5 months ago.

There is no cure for Chronic leukemia. Life span is on average at about 4 years. Answered by Susanne Strobridge 5 months ago.

I know someone who was treated by acupuncture and it helped. And my friends neighbour ate (i dont know the exact name in English) "black radish" every day and he was completely cured in half a year. He refused chemotherapy.This vegetable contains incredible amount of various antioxidants and other stuff. He did not have leukemia, i think it was some other type of cancer, but i think it could help. Also my mother told me she heard about cases when it worked. Id would be a good idea to consider alternative therapies as well if modern medicine cant help. I know people who profited from it and ive seen a serious TV documentary about "incurable" diseases that were cured by traditional medicine. Good luck! I will pray for you Answered by Ryan Krudop 5 months ago.

Leukemia is a form of cancer. The modifier 'chronic' only represents the continuous presence of the disease/condition/permanence of the affliction. As with any cancer or immune deficiancy...it is not currently curable. Leukemia is a particularly destructive disease, and usually ends lives fairly quickly. 2-3 years after 4th stage onset of the disease, depending on the immunity of the subject. Answered by Cyrus Biener 5 months ago.

Depends on many factors including age, phase and, genetic profile. In general, chronic leukemias are difficult to cure. It sounds counter-intuitive but, since chronic leukemias divide slowly, they are harder to cure. This is because most tradition cancer therapy is with chemotherapy which kills actively dividing cells. Newer targeted therapies, which bind to the proteins produced by cancer genes, have produced remarkable results with very mild side effects (mainly skin rash). These drugs include Imatinib (Gleevec), Dasatinib (Sprycel) and, Nioltinib (Tasigna). Many patients on these drugs have achieved indefinite remissions for people with chronic myelogenous leukemia (CML). However, in leukemia these drugs are only used for Philadelphia chrosome (translocation of chromosomes 9 and 22) positive (Ph+) leukemias because they target they oncoprotein produced. Answered by Coleen Tweed 5 months ago.

A young boy who used to live near me had leukemia and they treated and cured him. So there has been progress in the treatment of this old malady. I don't know how much luck they have in adults with this but I think getting started on the treatment as soon as possible is one of the things that counts a lot towards cure or recovery. btw that boy is 30 years old now and when I saw him first, he was seven years old and his treatment was already working. Answered by Markus Gerych 5 months ago.

Long term blood cancer, curable only with a bone marrow transfusion, but chances of recurrances are reported. Life span can vary depending on which stage the cancer the person is in. so can be 3 months - 15 years. *this is just an estimate. Answered by Warner Britain 5 months ago.

I don't wish to alarm you here, but I will answer your question honestly.. I had a mate who was diagnosed with leukaemia and within about 3 mths he was walking in the land of the spirit's .. He had not reached his 38th birthday.. He had bone marrow transplant from his brother which he rejected..Now my mate was a fit and healthy sort of bloke and he obviously didn't know he was crook , then he felt a bit of fatigue and had to see a doctor ... Had some tests and was admitted to hospital all within a week and he never came home ... The rest is history ... Blessed Be Answered by Luci Mcklveen 5 months ago.

Sorry in most cases no it is not. It can be delayed some and even long enough to finish a rather long life but eventually the answer is no it can't be cured. Answered by Deon Burgos 5 months ago.

How to treat blood cancer?
Anyone who know how to Treat Blood Cancer please Help me Asked by Courtney Juenemann 5 months ago.

Leukemia is cancer of your body's blood-forming tissues, including your bone marrow and lymphatic system. It usually starts in your white blood cells. Your white blood cells are potent infection fighters — they normally grow and divide in an orderly way, as your body needs them. But in leukemia, your bone marrow produces a large number of abnormal white blood cells, which don't function properly. Leukemia isn't just a children's disease. It has four main types and many subtypes — and only some are common among children. A diagnosis of leukemia can cause you a great deal of concern, and treatment can be complex — varying on the type of leukemia and other factors. But there are strategies and resources that may make your road easier. Unlike other types of cancer, leukemia isn't a solid tumor that your doctor can surgically remove. Leukemia treatment is complex. It depends on many factors, including your age and overall health, the type of leukemia you have and whether it has spread to other parts of your body. Therapies used to fight leukemia include: Chemotherapy. Chemotherapy is the major form of treatment for leukemia. This treatment uses chemical agents to kill leukemia cells. Depending on the type of leukemia you have, you may receive a single drug or a combination of one or more drugs. These drugs may come in a pill form, or they may be injected directly into a vein. Biological therapy. Also known as immunotherapy, biological therapy uses substances that bolster your immune system's response to cancer. Kinase inhibitors. For most people with CML, the drug imatinib mesylate (Gleevec) is the first line of therapy. Imatinib mesylate is a type of cancer drug called a kinase inhibitor. It was specifically developed to inhibit the BCR-ABL protein, and it has proved effective in treating the early stages of chronic myelogenous leukemia. The Food and Drug Administration has approved two other kinase inhibitors, dasatinib (Sprycel) and nilotinib (Tasigna), which may help people who can't take or who've become resistant to imatinib. Other drug therapy. Arsenic trioxide and all-trans retinoic acid (ATRA) are anti-cancer drugs that doctors can use alone — or in combination with chemotherapy — to treat a certain subtype of AML called promyelocytic leukemia. These drugs cause leukemia cells with a specific gene mutation to mature and die. Radiation therapy. Radiation therapy uses X-rays or other high-energy rays to damage leukemia cells and stop their growth. You may receive radiation in one specific area of your body where there is a collection of leukemia cells, or you may receive radiation directed at your whole body. Bone marrow transplant. This process replaces your leukemic bone marrow with leukemia-free marrow. In this treatment, you receive high doses of chemotherapy or radiation therapy, which destroys your leukemia-producing bone marrow. This marrow is then replaced by bone marrow from a compatible donor. In some cases, you may also be able to use your own bone marrow for transplant (autologous transplant). This is possible if you go into remission and then save healthy bone marrow for a future transplant, in case the leukemia returns. Stem cell transplant. Stem cell transplant is similar to bone marrow transplant except the cells are collected from stem cells that circulate in the bloodstream (peripheral blood). The cells used for transplant can be your own healthy cells (autologous transplant), or they can be collected from a compatible donor (allogeneic transplant). Doctors use this procedure more frequently than bone marrow transplant because of shortened recovery times and possible decreased risk of infection. - Answered by Yi Reinkemeyer 5 months ago.

Blood cancer is a type of cancer in which the production and function of your body cells get affected. Blood and bone are the main focus of blood cancer but it can also affect lymph and lymphatic system. Blood cancer is mainly categorized in to three: Leukemia, Lymphoma and Myeloma Cytarabine is a chemotherapy agent which is used in the treatment of blood cancer. It is highly effective in the treatment of cancers of white blood cells or lymphoma. It also suppresses the activity of DNA and RNA polymerases. These are the enzymes which plays a major role in the synthesis of the DNA. Buy Cytarabine to treat the blood cancer in its early stages. Answered by Latrisha Mulroney 5 months ago.

This Site Might Help You. RE: How to treat blood cancer? Anyone who know how to Treat Blood Cancer please Help me Answered by Missy Kallus 5 months ago.

We would need to know the specific disease you are asking about. There are many different types of malignancies related to blood cells - leukemias, lymphomas, plasma cell dyscrasias, etc. These represent more than 30 diseases. Most are treated with chemotherapy agents. There are more than 75 chemotherapy drugs and hundreds of different combination regimens. Answered by Danette Nguyen 5 months ago.

Usually cancer is not contagious BUT YES IT CAN BE TRANSMITTED, CANCER CAN BE TRANSMITTED IN ONE WAY... You are donated an organ that has cancer in it, your body will usually attack the organ and cancer so they give your drugs to suppress your immune system so it stops fighting the organ and cancer :(. BLOOD CANCER??? You sure you have that right? Answered by Jose Sidley 5 months ago.

Very Useful information .......... Medicine for blood cancer has been found please forward maximum, 'Imitinef Mercilet' is a medicine which cures blood cancer. its available free of cost at "Adyar Cancer Institute of Chenni". Create Awareness. It might help someone. Answered by Inge Klimesh 5 months ago.

Blood Cancer - Chronic Myeloid Leukemia (CML)?
Dear Sir,I am an Indian National. I have been suffering from Blood Cancer (Chronic Myeloid Leukemia - CML) for the last 3 years. I have been continuously taking medicines & going for bone marrow test every six months. Now as per my Doctors, this medicine is not enough to control the situation. Doctors says,... Asked by Jeffie Rieg 5 months ago.

Dear Sir, I am an Indian National. I have been suffering from Blood Cancer (Chronic Myeloid Leukemia - CML) for the last 3 years. I have been continuously taking medicines & going for bone marrow test every six months. Now as per my Doctors, this medicine is not enough to control the situation. Doctors says, there is continuous reduction of hemoglobin & chromosomes in my body. Doctors prescribed me now new medicince called “DASATINIB” Please let me know the following:- 1.Name of the Countries, where I can get “Dasatinib” medicine. 2.Is it available in India or nearby countries? Please provide contact details (Telephone number & e-mail). 3.What is the approximate cost of “Dasatinib” per Tablet? 4.Treatment of Blood Cancer (Chronic Myeloid Leukemia) is very expensive and now out of my budget. I am a low income person & I can not afford expensive medicine as well as I can not pay for the treatment. Please let me know if there is any Charity or free Cancer Treatment Hospital any where in the World. Please provide contact details (Telephone number & e-mail). 5.Is there any Charity, who can provide me “Dasatinib” or free Cancer Treatment? 6.I have been working in Kuwait (Middle East). There is Free Cancer Hospital (KCC) in Kuwait. I have been getting free treatment of Cancer but Medicines I have to buy my own. Kuwait Cancer Center is giving free Medicines only for Kuwaiti Nationals but not for any other expatriates. Your prompt & valuable advice will be highly appreciated on the above Regards Sachidanand Sati From The State of Kuwait Tel. No. 00965 – 99498601 E-Mail : [email protected] Answered by Chere Ayo 5 months ago.

I have blood cancer too. I also work for the Leukemia & Lymphoma Society in the Desert Mtn States Chapter. Try LLs.org (school and youth program code EXT 7597) or email me and I will reply with my toll free office number. Answered by Portia Eull 5 months ago.

What drugs inteact with zanac?? i ran out of my nexium and got gerd..but i have the zantacs 150mgs?
please help?? Asked by Rosann Faupel 5 months ago.

Here is a list of drugs that interact with zantac... according to micromedex major drug interactions: Atazanavir (probable) Dasatinib (theoretical) Delavirdine (theoretical) Tolazoline (probable) moderate drug interactions: Cefpodoxime Proxetil (probable) Dicumarol (probable) Enoxacin (probable) Fosamprenavir (probable) Gefitinib (probable) Glipizide (probable) Itraconazole (probable) Risperidone (probable) Triazolam (probable) Warfarin (probable) Answered by Johnette Redish 5 months ago.


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Bristol-Myers Squibb Pharmaceuticals Ltd

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