DANTRIUM Ressources

Application Information

This drug has been submitted to the FDA under the reference 017443/001.

Names and composition

"DANTRIUM" is the commercial name of a drug composed of DANTROLENE SODIUM.
It belongs to the class Skeletal muscle relaxants and is used in Muscle spasm (Musculoskeletal Disorders)

Answered questions

What is dantrium?
Asked by Meridith Shoobridge 6 months ago.

They are a rock Band in England from 1964-1981 Answered by Dorothea Hutcheson 6 months ago.

How does Dantrium work?
Most specifically, what is it's exact role in the treatment of Malignant Hyperthermia? Does it just reverse muscle contraction, thus halting the subsequent cascade of complications caused by constant contraction of the muscles? Asked by Abram Newbell 6 months ago.

There's a drug I hope I never have to use! Dantrolene depresses the intrinsic mechanisms of excitation-contraction coupling in skeletal muscle. However, its precise mechanism of action and its molecular targets are still incompletely known. Recent studies have identified the ryanodine receptor as a dantrolene-binding site. A direct or indirect inhibition of the ryanodine receptor, the major calcium release channel of the skeletal muscle sarcoplasmic reticulum, is thought to be fundamental in the molecular action of dantrolene in decreasing intracellular calcium concentration. Dantrolene is not only used for the treatment of malignant hyperthermia, but also in the management of neuroleptic malignant syndrome, spasticity and Ecstasy intoxication. The main disadvantage of dantrolene is its poor water solubility, and hence difficulties are experienced in rapidly preparing intravenous solutions in emergency situations. Due to economic considerations, no other similar drugs have been introduced into routine clinical practice. It is also one very expensive drug. Facilities that use general anesthesia must have 36 vials on hand, at about $100 per vial. Answered by Ramonita Lueth 6 months ago.

1DANTRIUM(R)CapsulesDantrolene sodiumConsumer Medicine InformationWhat is in this leafletPlease read this leaflet carefully.This leaflet answers some commonquestions about DANTRIUMcapsules. It does not contain all theavailable information. It does nottake the place of talking to yourdoctor or pharmacist.All medicines have risks andbenefits. Your doctor has weighedthe risks of treating you withDANTRIUM against the expectedbenefits it will have for you.If you have any concerns aboutbeing treated with this medicine,ask your doctor.What DANTRIUM isused forDANTRIUM capsules are used torelax muscles which are in spasm as aresult of spinal cord injury, stroke,cerebral palsy or multiple sclerosis.It is of particular help to thosepatients whose rehabilitation is beingslowed down by muscle spasm.Your doctor may have prescribedDANTRIUM capsules for anotherreason. Ask your doctor if you haveany questions about whyDANTRIUM has been prescribed foryou.Before you takeDANTRIUMWhen you must not take itDo not take DANTRIUM capsulesif:* you have liver disease such ashepatitis and cirrhosis* muscle spasm allows you to keepan upright position, balanceduring movement or betterphysical function* you are allergic to it or any of theingredients listed at the end ofthis leaflet* the bottle or packaging showssigns of tampering* the expiry date on the pack haspassedIf this medicine is taken after theexpiry date has passed, it may notwork.Before you start to take itTell your doctor if:1. you have liver problemsIt is essential to have your liverchecked by your doctor beforetaking DANTRIUM, todetermine if you have anyexisting problems with yourliver.2. you have problems with yourbreathing3. you have heart problems4. you have kidney problems5. you are pregnant or intend tobecome pregnantYour doctor will discuss thepossible risks and benefits ofusing DANTRIUM duringpregnancy.6. you are breastfeeding or intend tobreastfeedDANTRIUM should not be usedwhile breastfeeding.Taking other medicinesTell your doctor if you are takingany other medicines, including anythat you buy without aprescription from your pharmacy,supermarket or health food shop.Some medicines and DANTRIUMmay interfere with each other. Theseinclude:* medicines containing oestrogen,which include oral contraceptivesand medicines used to treatsymptoms of menopause.* calcium channel blockers such asverapamil, used to treat highblood pressure.* other muscle relaxant medicineswhich work differently toDANTRIUM* CNS depressants (medicines toreduce anxiety or help you sleep)How to take DANTRIUMHow much to takeYour doctor will decide how muchDANTRIUM you should take eachday and how long your treatment --------------------------------------... Page 2 DANTRIUM(R) CAPSULES2with DANTRIUM should continue.Take the capsules exactly asinstructed by your doctor orpharmacist.When to take itYour doctor will tell you how manytimes a day you should takeDANTRIUM.Always read the pharmacist's labelto check the exact dose and howoften to take it.If you forget to take itIf it is almost time for your nextdose, skip the dose you missed andtake your next dose when you aremeant to.Otherwise, take it as soon as youremember, and then go back totaking it as you would normally.Do not take a double dose to makeup for the dose that you havemissed.If you are not sure whether to skipthe dose, ask your doctor orpharmacist for advice.If you take too much(overdose)Immediately telephone yourdoctor, or the Poisons InformationCentre (telephone 131 126), or goto accident and emergency at yournearest hospital, if you think youor anyone else may have taken toomuch DANTRIUM. Do this even ifthere are no signs of discomfort orpoisoning.You may need urgent medicalattention.Symptoms of a DANTRIUMoverdose include the side effectslisted below in the "Side Effects"section, but are usually of a moresevere nature. In addition,unconsciousness may occur.While you are usingDANTRIUMThings you must doKeep all your doctor'sappointments so your progress andhealth can be monitored.DANTRIUM can cause damage toyour liver, so your liver functionneeds to be checked regularly byyour doctor to detect anyabnormalities.If you become pregnant whilebeing treated with DANTRIUM,tell your doctor immediately.If you are about to be started onany new medicine, tell your doctorand pharmacist that you are beingtreated with DANTRIUM.Tell all doctors, dentists andpharmacists who are treating youthat you are taking DANTRIUM.Things you must not doDo not drive or operate machinerywhile you are taking DANTRIUM.DANTRIUM causes drowsiness,dizziness and weakness in somepeople and therefore may affectalertness.Avoid drinking alcohol or takingmedicines to reduce anxiety or helpyou sleep.These may increase the drowsinessand dizziness effects of DANTRIUMand should be avoided.Things to be careful ofBe careful of exposure to sunlightwhile being treated withDANTRIUM.DANTRIUM may increasesensitivity of the skin to sun.Symptoms of sunburn (such asredness, itching, swelling orblistering) may occur more quicklythan normal.Side effectsTell your doctor as soon as possibleif you do not feel well while you arebeing treated with DANTRIUM.All medicines can have side effects.You may need medical treatment ifyou get some of the side effects.Ask your doctor or pharmacist toanswer any questions you mayhave.Tell your doctor if you notice anyof the following and they worryyou:* drowsiness* dizziness* weakness* fatigue* diarrhoea* general feeling of being unwell* shortness of breath and chest pain* constipation* loss of appetite* difficulty swallowing* stomach cramps/pain* vomiting* speech problems* headache* nausea* light-headedness* visual problems, includingdouble vision* alteration of taste* trouble sleeping* depression* mental confusion* frequent urination* increased urination at night* difficulties in obtaining anerection* abnormal hair growth* rashes* sweating* backache* muscle pain* feeling of suffocation, excessivetearing, chills and fever --------------------------------------... Page 3 DANTRIUM(R) CAPSULES3Tell your doctor immediately ifyou notice any of the following:* swelling of the face, lips, tongueor other parts of the body,shortness of breath, wheezing ortrouble breathing* swelling of the liver which canresult in yellowing of the skinand eyes, lower back pain, darkurine, nausea, vomiting, loss ofappetite, fever, itching and ageneral feeling of being unwell* gastrointestinal bleeding* fits or convulsions* fast heart rate* shortness of breath and swellingof the feet or legs* crystals or blood in the urine* loss of control of the bladder* difficulty passing or inability topass urineThese may be serious side effects ofDANTRIUM. You may need urgentmedical attention.Other side effects not listed abovemay also occur in some patients.Tell your doctor if you notice anyother effects.Do not be alarmed by this list ofpossible side effects.You may not experience any of them.After using DANTRIUMStorageKeep your capsules in a cool dryplace where the temperature staysbelow 30 degrees C.Do not store DANTRIUM or anyother medicine in a bathroom ornear a sink.Do not leave it in the car or onwindow sills on hot days.Heat and dampness can destroy somemedicines.Keep your DANTRIUM capsuleswhere children cannot reach them.A locked cupboard at leastone-and-a-half metres above theground is a good place to storemedicines.DisposalIf your doctor tells you to stop takingDANTRIUM, or the capsules havepassed their expiry date, ask yourpharmacist what to do with anycapsules that are left over.Product descriptionWhat it looks likeDANTRIUM capsules are availablein 25 mg and 50 mg strengths.DANTRIUM 25 mg capsules areorange and tan and marked in blackwith "DANTRIUM 25 mg", "0149","0030" and a single line. The 25 mgcapsules are available in bottles of100 capsules.DANTRIUM 50 mg capsules areorange and tan and marked in blackwith "DANTRIUM 50 mg", "0149","0031" and a double line. The 50 mgcapsules are available in bottles of100 capsules.IngredientsThe active ingredient inDANTRIUM capsules is dantrolenesodium. DANTRIUM capsules alsocontain maize starch, purified talc,magnesium stearate, lactose, gelatin,iron oxide red CI77491, iron oxideyellow CI77492, sunset yellow FCFCI15985, titanium dioxide, blackprinting ink (TekPrint SW-9008 orTekPrint SW-9010).IdentificationDANTRIUM capsules can beidentified by the Australian RegisterNumber on the bottle:25 mg: AUST R 4297550 mg: AUST R 42976SupplierDANTRIUM capsules are suppliedin Australia by:Pfizer Australia Pty LtdABN 50 008 422 34838-42 Wharf RoadWest Ryde NSW 2114AustraliaToll free number: 1800 675 229DANTRIUM capsules are suppliedin New Zealand by:Pfizer New Zealand LtdPO Box 3998Auckland, New ZealandToll Free Number: 0800 736 363This leaflet was revised on 14September 2006.(R) Registered trademark(C) Copyright Pfizer Australia PtyLtd Answered by Lynn Pauk 6 months ago.

Can someone get high off dantrium?...my mom is on it and im worried if she can get like high or loopy..?
Asked by Ilene Tafoya 6 months ago.

You can't get high off of it, but if you go off the meds people can become spastic and "loopy" as you say. Answered by Rae Domer 6 months ago.

No, I don't think so. It is really just one of those drugs to calm people down and reduce the probability of having a seizure, basically - often from serotonin syndrome. Answered by Asley Leheny 6 months ago.

Hi i have a brain injury and im wondering if i can take protein mixes such as dymatize and products such as?
i kno it wont help my injury but it will help me gain back my muscle that i lost Asked by Cyrus Dumlao 6 months ago.

Best to ask your doctor. Most are just proteins, but some have other ingredients that may interfere with your meds. If you want more protein, try eating more protein and less junk or carbs. Answered by Evangelina Carraher 6 months ago.

protein won't help brain injuries at all Answered by Chanell Zecchini 6 months ago.

I have multiple sclerosis and my stiffness is my only problem?
I have taken zanaflex and baclofen but neither of them work. Is there any other med out there that maybe could help me? I am so frustrated that the 2 won't work for me. I wish something else would come out. My dr. won't do dantrolene but I would like to give it a try just to see if it would work. But, she... Asked by Deena Lindel 6 months ago.

I have taken zanaflex and baclofen but neither of them work. Is there any other med out there that maybe could help me? I am so frustrated that the 2 won't work for me. I wish something else would come out. My dr. won't do dantrolene but I would like to give it a try just to see if it would work. But, she doesn't like this med. Have you heard of anything else that maybe could help me? Answered by Lelia Forand 6 months ago.

Multiple sclerosis is one of the most debilitating and discouraging conditions anyone can have. Waking up day after day knowing you are stricken with MS that gradually drags you, healthy young person, toward chronic illness and maybe shorter life. Suddenly you no longer expect to enjoy many of life's greatest experiences. The inside story on Dr. Gary remarkable Multiple Sclerosis cure Read on to discover what really causes your multiple sclerosis! Answered by Karisa Foshie 6 months ago.

Hi Pumky, I take LDN (low dose naltrexone), and that works for me. My neurologist has been prescribing this drug for her patients with MS for three years now. It not only takes care of my stiffness but it has reduced my fatigue down to nothing. Too bad your doctor prescribes drugs on the basis of her own biases. Every drug has pros and cons. LDN is still in trials for autoimmune diseases, but it is FDA approved, and it is a generic to boot so it is exceptionally cheap. Good luck to you. I hope you find something that works. Answered by Arturo Beltron 6 months ago.

MS, according to main stream medicine is not curable and they sentence you to a life of drugs, pain, and shorter life. It is a degenerative disease. If you believe that and take the drugs, your chances of getting better diminish every day. Multiple Sclerosis is caused by something, not a natural aging process. Why not work on making your body healthy instead of treating the symptoms? It's not easy to be healthy in America today and when you get diagnosed with things like MS, it's even more difficult and easy to become disillusioned. I've never known anyone that was deficient in drugs. The SAD diet (standard American diet) promotes sickness and diseases. All one has to do is look at the statistics to prove that. The simple fact that primitive man did not have cavities or even plaque build up on his teeth should tell you something. The first case of cardio myfarction in America was recorded in 1921. Cancer & heart disease challenge each other for the number one killer in the U.S. now and that is after billions of dollars have been spent on research. Stroke is now number 3. 26% of ALL Americans have pre-diabetes or diabetes now. "Jerry's Kid's" are still sick after $1billion dollars collected. Yet, primitive man did not have these problems. There are many cultures in the world where doctors are not needed. MS is all part of this insanity. If you look to drugs to solve your problem, you need to free yourself from the lies you believe. I would concentrate on making your body healthy, getting rid of the heavy metal burdens most likely generating much of the MS issues, and focus on good solid nutrition. good luck to you Answered by Candra Calicutt 6 months ago.

Can u fail a drug test by taking muscle relaxers?
i get random drug tests and i was wondering if taking muscle relaxers were safe to pass Asked by Letitia Kabel 6 months ago.

If you have a prescription, it won't be a problem even if it is tested for. Most muscle relaxants includingParafon Forte DSC (chlorzoxazone), Skelaxin (metaxalone), Dantrium (dantrolene), Flexeril, Amrix, Fexmid (cyclobenzaprine), Norflex (orphenadrine), Robaxin (methocarbamol), Zanaflex (tizanidine), and Lioresal (baclofen) are NOT controlled substances and are not tested for in drug tests. However Valium (diazepam), a benzodiazepine, may be tested for and it is a schedule IV controlled substance. Other benzodiazepines like Ativan (lorazepam), Klonopin, Rivotril (clonazepam) are also sometimes used as muscle relaxants and, like Valium, may be tested for. Also the drug Soma (carisoprodol) is sometimes tested for but it is uncommon. Soma is a not a federally controlled substance in The US however many states list it as a schedule IV drug. Answered by Ava Sliwinski 6 months ago.

Baclofen Drug Test Answered by Myrl Wubnig 6 months ago.

This Site Might Help You. RE: can u fail a drug test by taking muscle relaxers? i get random drug tests and i was wondering if taking muscle relaxers were safe to pass Answered by Sharron Cornes 6 months ago.

Not completely sure about this one Answered by Jada Tanimoto 6 months ago.

Great answers given Answered by Rolanda Ginnis 6 months ago.

how long does it take to pass thru Answered by Niki Teston 6 months ago.

you should be able to pass, but id be careful Answered by Floy Hartery 6 months ago.

If you take antibiotics and you get a real bad headache from it would you stop?
The medicine is call Erythromycin base 500 Asked by Crystal Shoffner 6 months ago.

Side Effects of This Medicine: Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Fever; headache, nausea; skin rash, redness, or itching; stomach pain (severe); unusual tiredness or weakness; vomiting; yellow eyes or skin-with erythromycin estolate (rare with other erythromycins) Pain, swelling, or redness at place of injection Fainting (repeated); irregular or slow heartbeat; loss of hearing (temporary) Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking or receiving erythromycins, it is especially important that your health care professional know if you are taking any of the following: Acetaminophen (e.g., Tylenol) (with long-term, high-dose use) or Amiodarone (e.g., Cordarone) or Anabolic steroids (nandrolone [e.g., Anabolin], oxandrolone [e.g., Anavar], oxymetholone [e.g., Anadrol], stanozolol [e.g., Winstrol]) or Androgens (male hormones) or Antithyroid agents (medicine for overactive thyroid) or Carmustine (e.g., BiCNU) or Chloroquine (e.g., Aralen) or Dantrolene (e.g., Dantrium) or Daunorubicin (e.g., Cerubidine) or Disulfiram (e.g., Antabuse) or Divalproex (e.g., Depakote) or Estrogens (female hormones) or Etretinate (e.g., Tegison) or Gold salts (medicine for arthritis) or Hydroxychloroquine (e.g., Plaquenil) or Mercaptopurine (e.g., Purinethol) or Methotrexate (e.g., Mexate) or Methyldopa (e.g., Aldomet) or Naltrexone (e.g., Trexan) (with long-term, high-dose use) or Oral contraceptives (birth control pills) containing estrogen or Other anti-infectives by mouth or by injection (medicine for infection) or Phenothiazines (acetophenazine [e.g., Tindal], chlorpromazine [e.g., Thorazine], fluphenazine [e.g., Prolixin], mesoridazine [e.g., Serentil], perphenazine [e.g., Trilafon], prochlorperazine [e.g., Compazine], promazine [e.g., Sparine], promethazine [e.g., Phenergan], thioridazine [e.g., Mellaril], trifluoperazine [e.g., Stelazine], triflupromazine [e.g., Vesprin], trimeprazine [e.g., Temaril]) or Phenytoin (e.g., Dilantin) or Plicamycin (e.g., Mithracin) or Valproic acid (e.g., Depakene)—Use of these medicines with erythromycins, especially erythromycin estolate, may increase the chance of liver problems Aminophylline (e.g., Somophyllin) or Caffeine (e.g., NoDoz) or Oxtriphylline (e.g., Choledyl) or Theophylline (e.g., Somophyllin-T, Theo-Dur)—Use of these medicines with erythromycins may increase the chance of side effects from aminophylline, caffeine, oxtriphylline, or theophylline Astemizole (e.g., Hismanal) or Terfenadine (e.g., Seldane)—Use of astemizole or terfenadine with erythromycins may cause heart problems, such as an irregular heartbeat; these medicines should not be used together Carbamazepine (e.g., Tegretol)—Use of carbamazepine with erythromycin may increase the side effects of carbamazepine or increase the chance of liver problems Chloramphenicol (e.g., Chloromycetin) or Clindamycin (e.g., Cleocin) or Lincomycin (e.g., Lincocin)—Use of these medicines with erythromycins may decrease the effectiveness of these other antibiotics Cyclosporine (e.g., Sandimmune) or Warfarin (e.g., Coumadin)—Use of any of these medicines with erythromycins may increase the side effects of these medicines Other medical problems—The presence of other medical problems may affect the use of erythromycins. Answered by Annelle Marfil 6 months ago.

I'd page my doctor right away to ask if the headache is actually related to the medication and not something happening by chance. Only your doctor can advise you whether you should take a medication or not--remember also to tell the doctor the names of the other medications you're on to make sure there's not an interaction. Answered by Angelica Sazama 6 months ago.

It is not likely that the antibiotic is giving you the headache. You have to finish your antibiotics, as long as you don't have a life threatening reaction. Take some Tylenol for your head. If it is really bothering you, you should ask your parents, anyway. Answered by Theo Sticher 6 months ago.

in case you get a headache because of the fact of taking the medicine and as you think of you're clearing up now, you are able to desire to not proceed taking the medicine. Drink countless comfortable beverages, shop hydrated to have sufficient kidney filtration. Answered by Tora Mapp 6 months ago.

Headaches aren't a side effect to this drug (in a general sense). Don't stop taking it unless the prescribing doctor says so. Answered by Trudi Hones 6 months ago.

Valium For Muscle Spasm?
Im one month post cast from a trimallelor fracture (compound OUCh) Was wondering if its OK to ask my GP for a script of Valium since i still have painful muscle spams?! ( I just read that valium is habit forming so docs dont like to write it.. Is there any alternative medication ?! Asked by Shayne Dings 6 months ago.

Just talk to your doctor and tell him that you have been having painful muscle spasms. There are a number of muscle relaxants including: Zanaflex (tizanidine) Norflex (orphenadrine) Flexeril (cyclobenzaprine) Soma (carisoprodol)- a controlled substance in some US states Soma Compound (carisoprodol/aspirin)- a controlled substance in some US states Soma Compound with Codeine (carisoprodol/aspirin/codeine)- a schedule III controlled substance Valium (diazepam)- schedule IV controlled substance Miltown (meprobamate)- a schedule IV controlled substance There is very limited or inconsistent data regarding the effectiveness of the following Parafon Forte DSC (chlorzoxazone) Robaxin (methocarbamol) Skelaxin (metaxalone) Dantrium (dantrolene) Lioresal (baclofen) Granted Valium (diazepam) does have a potential for abuse but in some cases it is the best medication and it is a massive overgeneralization that doctors don't like to prescribe it. Since muscle relaxants are typically used for a short time and since Valium so extremely effective and it tends to have few side effects and is well tolerated it is often prescribed. Although in general Flexeril and Soma are the most commonly used medications and both are typically very effective. In some cases it can take a couple of tries to find the best medication especially since not all muscle relaxants work in the same way. So just see what your doctor says and try his recommendation. Answered by Hassan Mondloch 6 months ago.

Just tell the doc that you are having spasms. Let them decide what medication you need. There are nonhabit - forming muscle relaxants. Answered by Desirae Gneiser 6 months ago.

Be cautious with any of the drugs to relieve muscle problems many---many --- many people get hooked on these try instead to accomplish physical adjustments--- Answered by Imogene Orantes 6 months ago.

Are there any good message boards/News groups for people with MS?
I have many symptoms, (off and on) of MS. I'm having trouble with my GP at getting a diagnosis & any help for that matter. Can anyone point me to a good News group? Asked by Darrin Clutts 6 months ago.

mswatch.com is great- you register but its free. It hard to get a dx, as docotrs may know its some type of neru problem but cant name it yet You need to go to a center or doctor that specializes in ms any question fee free to ask Answered by Hayley Favalora 6 months ago.

Oh my gosh... the post above this is awesome!! I'm am checking it out as soon as I leave this site.... thank you thank you, thank you I'm also going to print is for my sister !! Answered by Allan Gazaway 6 months ago.

you tell me i want to know too Answered by Dana Doney 6 months ago.


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