Application Information

This drug has been submitted to the FDA under the reference 005929/001.

Names and composition

"D.H.E. 45" is the commercial name of a drug composed of DIHYDROERGOTAMINE MESYLATE.

Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
005929/001 D.H.E. 45 DIHYDROERGOTAMINE MESYLATE INJECTABLE/INJECTION 1MG per ML

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
005929/001 D.H.E. 45 DIHYDROERGOTAMINE MESYLATE INJECTABLE/INJECTION 1MG per ML
020148/001 MIGRANAL DIHYDROERGOTAMINE MESYLATE SPRAY, METERED/NASAL 0.5MG per INH
040453/001 DIHYDROERGOTAMINE MESYLATE DIHYDROERGOTAMINE MESYLATE INJECTABLE/INJECTION 1MG per ML
040475/001 DIHYDROERGOTAMINE MESYLATE DIHYDROERGOTAMINE MESYLATE INJECTABLE/INJECTION 1MG per ML

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Answered questions

Have you ever taken D.H.E.A. as a supplement? Good, bad experiences? Any good gains? $4.99 at GNC. Cheap!?
I take 25 mg a day tablet. Been on it about 45 days now. I've been having E.D. lately, not sure if it is related. I'm only 27. 6'3'', 245 lbs. Asked by Teressa Rafla 1 year ago.

I didn't think you were supposed to take DHEA if you were under 40 years of age. Check the bottle to see if it says something about this or at least check it out somehow. Answered by Maribel Obanion 1 year ago.

I have heard that unless you are over 50 taking DHEA will make little difference according to clinical trials. This is because at 27 you already have alot of DHEA, too much can be a problem because you are messing with hormones, Good luck Answered by Jazmin Mure 1 year ago.


Can I mix these prescription medications?
I take seroquel and lamictal, bipolar medications. I have a really bad sinus infection. Does mucinex mix with these medications? I know there's only certian over the counter meds that mix with mine. If anyone who knows about these prescriptions could help me out that would be great. Please only answer if you know... Asked by Jenee Rollend 1 year ago.

I take seroquel and lamictal, bipolar medications. I have a really bad sinus infection. Does mucinex mix with these medications? I know there's only certian over the counter meds that mix with mine. If anyone who knows about these prescriptions could help me out that would be great. Please only answer if you know for sure if you don't move on to the next question don't make a stupid comment about nothing you know. Answered by Jude Akerley 1 year ago.

Mucinex is a multi-ingredient drug consisting of pseudoephedrine and guaifenesin. If you'd like to know more about how either one interacts with other medication, Google "pseudoephedrine drug interactions" and "guaifenesin drug interactions," although I don't believe you should be having any problems while on seroquel and lamictal. Here's a list of medication that WILL, however, interact with Mucinex, which I have looked into to double-check myself. I didn't see either of the two medications that you are on on any of the three lists, but here they are anyway, in case you'd like to see so for yourself: Major Interactions Atapryl, Azilect, Carbex, Eldepryl, Emsam, furazolidone, Furoxone, isocarboxazid, Jumex, linezolid, Marplan, Matulane, Nardil, Parnate, phenelzine, procarbazine, rasagiline, selegiline, Selgene, tranylcypromine, Zelapar, Zyvox Moderate Interactions acarbose, acetoHEXAMIDE, Aldomet, Amaryl, Apidra, Apidra OptiClik Cartridge, bromocriptine, chlorproPAMIDE, Citra pH, Citrate-Phos-Dex, D.H.E. 45, deserpidine, DiaBeta, Diabinese, dihydroergotamine, Dymelor, epoprostenol, ergoloid mesylates, Ergomar, ergonovine, ergotamine, Ergotrate Maleate, EXUBERA, EXUBERA Combination Pack 12, EXUBERA Combination Pack 15, EXUBERA Kit, Flolan, Fortamet, glimepiride, glipiZIDE, glipiZIDE extended release, GlipiZIDE XL, Glucophage, Glucophage XR, Glucotrol, Glucotrol XL, Glumetza, glyBURIDE, glyBURIDE micronized, Glynase PresTab, Glyset, guanadrel, guanethidine, Harmonyl, Humalog, Humalog Cartridge, Humalog KwikPen, Humalog Pen, Humulin L, Humulin N, Humulin N Pen, Humulin R, Humulin R (Concentrated), Humulin U, Hydergine, Hydergine LC, Hylorel, Iletin II Lente Pork, Iletin II NPH Pork, Iletin II Regular Pork, Iletin Lente, Iletin NPH, Iletin Regular, iloprost, insulin, insulin analog, insulin aspart, insulin aspart protamine, insulin detemir, insulin glargine, insulin glulisine, insulin inhalation, rapid acting, insulin isophane, Insulin Lente Pork, insulin lispro, insulin lispro protamine, Insulin Purified NPH Pork, Insulin Purified Regular Pork, insulin regular, insulin zinc, insulin zinc extended, insulin, lente, insulin, NPH, insulin, ultralente, Inversine, Ismelin, Januvia, Lantus, Lantus OptiClik Cartridge, Lantus Solostar Pen, Lente insulin, Levemir, Levemir FlexPen, Levemir InnoLet, Levemir PenFill, mecamylamine, Meridia, metformin, metformin extended release, Methergine, methyldopa, methylergonovine, methysergide maleate, Micronase, midodrine, miglitol, Migranal, nateglinide, Neut, Novolin L, Novolin N, Novolin N Innolet, Novolin N PenFill, Novolin R, Novolin R Innolet, Novolin R PenFill, NovoLog, NovoLog FlexPen, NovoLog PenFill, NPH insulin, Orinase, Orvaten, oxytocin, Parlodel, Pitocin, potassium citrate, Prandin, Precose, ProAmatine, prostacyclin, protamine zinc insulin, Rauwolfemms, Rauwolfia 1X, rauwolfia serpentina, regular insulin, Relion Novolin N, ReliOn/Novolin R, Remodulin, repaglinide, reserpine, Riomet, Sansert, sibutramine, sitagliptin, sodium acetate, sodium bicarbonate, sodium citrate, sodium lactate, Starlix, Syntocinon, Tham, Tol-Tab, TOLAZamide, TOLBUTamide, Tolinase, treprostinil, Tricitrasol, tromethamine, Twin-K, Ultralente insulin, Urocit-K, Velosulin BR, Ventavis Minor Interactions Acerola, ammonium chloride, Ascor L 500, ascorbic acid, Ascorbic Acid Quick Melts, Ascot, atomoxetine, C-Time, C/Rose Hips, Cardoxin, Cecon, Cee-500, Cemill 1000, Cemill 500, Cenolate, Centrum Singles-Vitamin C, Cevi-Bid, Cotameth, Digitek, digitoxin, digoxin, digoxin capsule, Ester-C, K-Phos Original, Lanoxicaps, Lanoxin, M-Caps, Mega-C/A Plus, methionine, N Ice with Vitamin C, Pedameth, potassium acid phosphate, sodium acid phosphate, sodium ascorbate, Strattera, Sunkist Vitamin C, Vicks Vitamin C Drops, Vitamin C, Vitamin C TR, Vitamin C with Rose Hips Answered by Lulu Altizer 1 year ago.

No interactions were reported. I also checked Mucinex D and Mucinex DM too, just in case. (I am a pharmacist, BTW) Answered by Bobby Moberley 1 year ago.


If your on celexa (the medication)......?
is there anything that your not supposed to combine with it? (like vitamins, certain foods, caffeine, anything?!) Asked by Cornelia Brinda 1 year ago.

Medication (in alphabetical order); Major Interactions 5-HTP, 5-hydroxytryptophan, Actiq, Acutrim 16 Hour, Acutrim II, Maximum Strength, Acutrim Late Day, Adapin, Adipex-P, Adipost, Alfenta, alfentanil, almotriptan, Amerge, amitriptyline, amoxapine, amphetamine, Anafranil, Anorex-SR, Aplenzin, Appecon, Asendin, Atapryl, Aventyl HCl, Axert, Azilect, Babee Cof, Balminil DM, Balminil DM Pour Enfants, Balminil DM Sans Sucrose, Benadryl for the Family Dry Forte, Benylin, Benylin Adult Formula, Benylin DM, Benylin DM Pediatric, Benylin Dry Coughs, Benylin Pediatric, benzphetamine, Bisolvon Dry, Bisolvon Dry Junior, Bontril PDM, Bontril Slow Release, Buckley's Mixture Cough Suppressant, Buckleys Mixture, Budeprion SR, Budeprion XL, buPROPion, buPROPion 24 hour extended release, buPROPion extended release, BuSpar, BuSpar Dividose, busPIRone, Calmylin, Carbex, Chem Mart Tramadol, clomiPRAMINE, Contac Cough, Control, Cough Relief, Cough Syrup DM, Covonia Bronchial Balsam, Creo-Terpin, Creomulsion, Creomulsion Children, Cymbalta, D.H.E. 45, Darvon, Darvon-N, Delsym, Delsym 12 Hour Cough Relief, Delsym 12 Hour Cough Relief for Children & Adults, Demerol HCl, desipramine, Desoxyn, Desoxyn Gradumet, desvenlafaxine, Desyrel, Desyrel Dividose, DexAlone, Dexatrim, Dexatrim Caffeine Free, Dexedrine, Dexedrine Spansule, dexfenfluramine, Dexi-Tuss, dextroamphetamine, dextroamphetamine extended release, dextromethorphan, dextromethorphan extended release, Dextromethorphan HBr Adult Formula, Dextrostat, Didrex, diethylpropion, diethylpropion extended release, dihydroergotamine, dihydroergotamine nasal, Dimetapp Cold Cough & Flu Day & Night Liquid Caps, doxepin, doxepin topical, Dristan DM, Dromadol SR, Dromadol XL, Dry Cough, duloxetine, Duragesic, Duragesic-100, Duragesic-12, Duragesic-25, Duragesic-50, Duragesic-75, Effexor, Effexor XR, Elavil, Eldepryl, eletriptan, Elixsure Cough, Empro, Emsam, Endep, ephedra, Ergomar, ergotamine, Eskalith, Eskalith-CR, Fastin, fenfluramine, fentanyl, fentanyl topical, Fentora, Frova, frovatriptan, furazolidone, Furoxone, GenRx Tramadol, GHB, Hold DM, hypericum perforatum, imipramine, imipramine pamoate, Imitrex, Imitrex Nasal, Imitrex Statdose, Imitrex Statdose Refill, iohexol, Ionamin, Ionsys, iopamidol, Iopamidol-370, isocarboxazid, Isovue-128, Isovue-200, Isovue-250, Isovue-300, Isovue-370, Isovue-M-200, Isovue-M-300, Jack & Jill Thin Strips Cough, Jumex, l-tryptophan, Larapam SR, levomethadyl acetate, linezolid, lisdexamfetamine, lithium, lithium carbonate, lithium carbonate extended release, lithium citrate, Lithobid, Lithonate, Lithotabs, Lloydspharmacy Dry Adult Cough, ma huang, Marplan, Matulane, Maxalt, Maxalt-MLT, Mazanor, mazindol, Mega-Trim, Melfiat, Mellaril, Mellaril-S, meperidine, Meridia, methamphetamine, methamphetamine extended release, metrizamide, Migranal, milnacipran, mirtazapine, Myelo-Kit, naratriptan, Nardil, nefazodone, Neocitran Thin Strips Cough, Norpramin, nortriptyline, Novahistine DM, Nucosef DM, Obephen, Obezine, Oby-Cap, Oby-Trim, Omnipaque 140, Omnipaque 180, Omnipaque 180 Redi-Unit, Omnipaque 210, Omnipaque 240, Omnipaque 240 Redi-Unit, Omnipaque 300, Omnipaque 350, Omnipaque Flexipak, Orap, Orlaam, Pamelor, Panshape M, Parnate, Pedia Relief, Pediacare, pentazocine, Pertussin CS Childrens, Pertussin DM, Pertussin ES, Phendiet, Phendiet-105, phendimetrazine, phendimetrazine extended release, phenelzine, Phentercot, phentermine, phentermine hydrochloride, phentermine hydrochloride extended release, phentermine resin extended release, Phentride, Phenyldrine, phenylpropanolamine, pimozide, Plegine, Pondimin, PP-Cap, Prelu-2, Pristiq, Pro-Fast HS, Pro-Fast SA, Pro-Fast SR, procarbazine, Propagest, Propan, propoxyphene, propoxyphene hydrochloride, propoxyphene napsylate, protriptyline, Prudoxin, rasagiline, Redux, Relpax, Remeron, Remeron SolTab, remifentanil, Rhindecon, rizatriptan, Robafen Cough Liquidgels, Robafen Pediatric Cough & Cold, Robitussin Cough Calmers, Robitussin CoughGels, Robitussin Dry Cough, Robitussin DX Cough Control, Robitussin DX Cough Control Forte, Robitussin DX Dry Cough Forte, Robitussin Honey Cough, Robitussin Junior Persistent Cough, Robitussin Maximum Strength, Robitussin Pediatric Cough Long-Acting, Robitussin Pediatric Cough Suppressant, Robitussin Soft Pastilles, Ryzolt, Sanorex, Savella, Scot-Tussin Diabetic, Scot-Tussin DM Cough Chasers, selegiline, Selgene, Serzone, sibutramine, Silphen DM, Sinequan, sodium biphosphate, sodium oxybate, St. John's wort, St. Joseph Cough Suppressant, Statobex, Strepsils Cough, Strepsils Cough Relief, Sublimaze, Sucrets DM Cough, Sufenta, sufentanil, sumatriptan, sumatriptan nasal, Surmontil, T-Diet, Talwin, Talwin Lactate, Tenuate, Tenuate Dospan, Teramine, Teramine ER, Terry White Chemists Tramadol, Theraflu Thin Strips Cough, thioridazine, Tofranil, Tofranil-PM, traMADOL, traMADOL extended release, Tramahexal, Tramahexal SR, Tramake, Tramake Insts, Tramal, Tramal SR, Tramedo, tranylcypromine Answered by Dennis Marrara 1 year ago.

There are no side effects at all. I have gone off of it several times and had no issues, although if you do decide to go back on, all that headache and stuff will come back. If the issue is not being able to pay for them I would like to suggest that i am taking a generic version of celexa called citralopram that only costs 20 dollars for 30 pills at 40mg. I hope i helped you, Answered by Weldon Cheatem 1 year ago.

Tramahexal Sr 100 Answered by Dorthey Gorham 1 year ago.


How to get rid of headachs?
i have a really bad headach Asked by Exie Hamara 1 year ago.

Put a ice pack on your head, it'll make it better, if it's very bad it'll most likely be a migraine. A variety of drugs have been specifically designed to treat migraines. In addition, some drugs commonly used to treat other conditions also may help relieve or prevent migraines. Medications used to combat migraines fall into two broad categories: Pain-relieving medications. Also known as acute or abortive treatment, these types of drugs are taken during migraine attacks and are designed to stop symptoms that have already begun. Preventive medications. These types of drugs are taken regularly, often on a daily basis, to reduce the severity or frequency of migraines. Choosing a strategy to manage your migraines depends on the frequency and severity of your headaches, the degree of disability your headaches cause, and your other medical conditions. Some medications aren't recommended if you're pregnant or breast-feeding. Some aren't used for children. Your doctor can help find the right medication for you. Pain-relieving medications For best results, take pain-relieving drugs as soon as you experience signs or symptoms of a migraine. It may help if you rest or sleep in a dark room after taking them: Pain relievers. These medications, such as ibuprofen (Advil, Motrin, others) or acetaminophen (Tylenol, others) may help relieve mild migraines. Drugs marketed specifically for migraines, such as the combination of acetaminophen, aspirin and caffeine (Excedrin Migraine), also may ease moderate migraine pain but aren't effective alone for severe migraines. If taken too often or for long periods of time, these medications can lead to ulcers, gastrointestinal bleeding and rebound headaches. The prescription pain reliever indomethacin may help thwart a migraine headache and is available in suppository form, which may be helpful if you're nauseous. Triptans. For many people with migraine attacks, triptans are the drug of choice. They are effective in relieving the pain, nausea, and sensitivity to light and sound that are associated with migraines. Medications include sumatriptan (Imitrex), rizatriptan (Maxalt), almotriptan (Axert), naratriptan (Amerge), zolmitriptan (Zomig), frovatriptan (Frova) and eletriptan (Relpax). Side effects of triptans include nausea, dizziness and muscle weakness. They aren't recommended for people at risk for strokes and heart attacks. A single-tablet combination of sumatriptan and naproxen sodium (Treximet) has proved more effective in relieving migraine symptoms than either medication on its own. Ergot. Ergotamine and caffeine combination drugs (Migergot, Cafergot) are much less expensive, but also less effective, than triptans. They seem most effective in those whose pain lasts for more than 48 hours. Dihydroergotamine (D.H.E. 45, Migranal) is an ergot derivative that is more effective and has fewer side effects than ergotamine. It's also available as a nasal spray and in injection form. Anti-nausea medications. Because migraines are often accompanied by nausea, with or without vomiting, medication for nausea is appropriate and is usually combined with other medications. Frequently prescribed medications are metoclopramide (Reglan) or prochlorperazine (Compro). Opiates. Medications containing narcotics, particularly codeine, are sometimes used to treat migraine headache pain when people can't take triptans or ergot. Narcotics are habit-forming and are usually used only as a last resort. Dexamethasone. This corticosteroid may be used in conjunction with other medication to improve pain relief. Because of the risk of steroid toxicity, dexamethasone should not be used frequently. Preventive medications You may be a candidate for preventive therapy if you have two or more debilitating attacks a month, if pain-relieving medications aren't helping, or if your migraine signs and symptoms include a prolonged aura or numbness and weakness. ~Kevin. Answered by Penney Berrian 1 year ago.

Drugs of any kind are BAD FOR YOU! They are laden with toxic chemicals, and we were ALL taught not to take poisons of ANY KIND!!!! You should be drinking more good quality water in the first place, and get plenty of fresh air. Put an icepack or packet of frozen peas on the site of the pain. Also place a pale blue cloth, or towel on the site, it will help ease the pain. Cost $0.00 How can major contributor give out advice that entails taking chemicals????? Pills cost money, and do damage to other parts of your body - don't be fooled in to taking chemicals for your ails. Answered by Anette Tinlin 1 year ago.


Would it be okay to take antibiotics and a medicine for colds at the same time?
i am taking erythromycin- an antibiotic for my throat. i also have colds. (got this stuffy, plugged up nose) though i haven't taken any medication for it yet. can you recomend any? -if thats okay to mix antibiotics with other drugs. Asked by Caridad Whitley 1 year ago.

cold medicines shouldn't have an interaction with your antibiotic. there are several prescription medications that can cause heart rhythm disorders, so if taking any of the following you should let your dr know immediately -digoxin (Lanoxin); -disopyramide (Norpace); - warfarin (Coumadin); -theophylline (Theo-Dur, Theobid, and others); -midazolam (Versed) or triazolam (Halcion); -ergotamine (Ercaf, Cafergot, Ergostat, Ergomar) or dihydroergotamine (D.H.E. 45, Migranal); - carbamazepine (Tegretol), phenytoin (Dilantin), or valproic acid (Depakote, Depakene); -tacrolimus (Prograf); - cyclosporine (Sandimmune, Neoral); - lovastatin (Mevacor) or simvastatin (Zocor); - bromocriptine (Parlodel); or - other antibiotics. any nasal decongestion medication should work. sudafed works well so you might want to try that one hope you feel better soon Answered by Derek Willougby 1 year ago.

For your information there is no medicine for killing cold virus. 'The antibiotic is only used to cure bacterial related diseases where as cold is virus related. Doctors prescribe antibiotics at later stage in colds to cure or prevent any bacterial diseases that might infect or infected. You can in this background need not fear for mixing cold and antibiotic drugs as in fact there are no cold medicines. If at all there are any cold medicines they are only meant for relieving the symptoms of the viral disease and bear with the pain and not the root-cause of the disease, that is for symptomatic relief. Better consult doctor for full info. Answered by Elfrieda Bertinetti 1 year ago.

people do it all the time. not sure what your medical history is, unless you have kidney or liver disease, breast feeding or pregnant, bone marrow transplant or immune disorder then i think you can take all of these together. i have always combined meds to get over the respiratory infection quicker. Answered by Neomi Late 1 year ago.

Call the local pharmacist or the one at Wal-Mart and ask them if there are any drug interactions. Answered by Modesta Reimmer 1 year ago.

please read up on erythromycin on the web for guidance Answered by Lashawn Poullion 1 year ago.


What should i do about this migrane i have had for 4days?
It hurts like all hell just to look at my phone screen to type this, I was prescribed imatrex but my two doses isn't even working now, I hate to hear myself talk, I have taken ibprophen & tylenol nothing helps, besides dark quiet room and I won't eat.No birth control, not really stressed, if anything... Asked by Darline Elhaddad 1 year ago.

It hurts like all hell just to look at my phone screen to type this, I was prescribed imatrex but my two doses isn't even working now, I hate to hear myself talk, I have taken ibprophen & tylenol nothing helps, besides dark quiet room and I won't eat. No birth control, not really stressed, if anything excited to be getting married on feb 18th. Answered by Berenice Chayka 1 year ago.

Congratulations on your engagement, that's wonderful. It sounds like the tryptans (imitrex) isn't working for you. You may need an ergot/caffiene combination (Migergot, Cafergot), which are more effective for people whose migraines last more than 48 hours. Dihydroergotamine (D.H.E. 45, Migranal), is a derivative of ergot, but is even more effective with fewer side effects. If those don't help, you may need an opiate, particularly, codeine, but use narcotics as a last resort, because they can be habit-forming. To prevent them: You may need beta-blockers/calcium channel blockers, tricyclic antidepressants, anti-seizure meds, or even botox. I hope you feel better, I've had them and know how incapacitating they can be. Answered by Sheila Trawick 1 year ago.

I suffered from migraines from the time I was 5 until I was 24. I started seeing a chiropractor & it changed my life. I stopped having headaches all together!! For now you can try ice packs on your neck because most headaches originate from the nerves in your neck, and be sure to stay hydrated. Find a local chiropractor. Answered by Gale Wahlquist 1 year ago.


How safe is imitrex for high blood pressure patients?
Asked by Lyla Promer 1 year ago.

Why should this drug not be prescribed? Return to top Imitrex should not be used for the hemiplegic or basilar forms of migraine. You must also avoid Imitrex if it gives you an allergic reaction. In addition, the drug should not be prescribed if you have certain types of heart or blood vessel disease, including angina (crushing chest pain) or a history of heart attack, stroke, mini-strokes, or other circulatory problems. It should not be used if you have severe liver disease or uncontrolled high blood pressure. It must not be used within 24 hours of taking an ergotamine-based migraine remedy (such as D.H.E. 45 Injection or Sansert) or any drug in the same class as Imitrex (such as Amerge, Maxalt, or Zomig). And it must not be used for 2 weeks after taking an MAO inhibitor drug such as the antidepressants Nardil and Parnate. Answered by Reba Conzemius 1 year ago.


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