Application Information

This drug has been submitted to the FDA under the reference 020870/001.

Names and composition

"COMBIPATCH" is the commercial name of a drug composed of ESTRADIOL and NORETHINDRONE ACETATE.

Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
020870/001 COMBIPATCH ESTRADIOL; NORETHINDRONE ACETATE FILM, EXTENDED RELEASE/TRANSDERMAL 0.05MG per 24HR and 0.14MG per 24HR
020870/002 COMBIPATCH ESTRADIOL; NORETHINDRONE ACETATE FILM, EXTENDED RELEASE/TRANSDERMAL 0.05MG per 24HR and 0.25MG per 24HR

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
020870/001 COMBIPATCH ESTRADIOL; NORETHINDRONE ACETATE FILM, EXTENDED RELEASE/TRANSDERMAL 0.05MG per 24HR and 0.14MG per 24HR
020870/002 COMBIPATCH ESTRADIOL; NORETHINDRONE ACETATE FILM, EXTENDED RELEASE/TRANSDERMAL 0.05MG per 24HR and 0.25MG per 24HR
020907/001 ACTIVELLA ESTRADIOL; NORETHINDRONE ACETATE TABLET/ORAL 1MG and 0.5MG
020907/002 ACTIVELLA ESTRADIOL; NORETHINDRONE ACETATE TABLET/ORAL 0.5MG and 0.1MG
021103/001 ACTIVELLA ESTRADIOL; NORETHINDRONE ACETATE TABLET/ ORAL 1MG per 0.5MG
022001/001 ACTIVELLA ESTRADIOL; NORETHINDRONE ACETATE TABLET/ ORAL 1MG per 0.5MG
078324/001 ESTRADIOL AND NORETHINDRONE ACETATE ESTRADIOL; NORETHINDRONE ACETATE TABLET/ORAL 1MG and 0.5MG
078324/002 ESTRADIOL AND NORETHINDRONE ACETATE ESTRADIOL; NORETHINDRONE ACETATE TABLET/ORAL 0.5MG and 0.1MG
079193/001 ESTRADIOL AND NORETHINDRONE ACETATE ESTRADIOL; NORETHINDRONE ACETATE TABLET/ORAL 1MG and 0.5MG
200747/001 ESTRADIOL AND NORETHINDRONE ACETATE ESTRADIOL; NORETHINDRONE ACETATE TABLET/ORAL 0.5MG and 0.1MG
203339/001 AMABELZ ESTRADIOL; NORETHINDRONE ACETATE TABLET/ORAL 0.5MG and 0.1MG
203339/002 AMABELZ ESTRADIOL; NORETHINDRONE ACETATE TABLET/ORAL 1MG and 0.5MG
207261/001 ESTRADIOL AND NORETHINDRONE ACETATE ESTRADIOL; NORETHINDRONE ACETATE TABLET/ORAL 0.5MG and 0.1MG
207261/002 ESTRADIOL AND NORETHINDRONE ACETATE ESTRADIOL; NORETHINDRONE ACETATE TABLET/ORAL 1MG and 0.5MG

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A licensed doctor will try to answer your question for free as quickly as possible. Free of charge during the beta period.

Answered questions

Menopause help? does anyone use the combipatch 50/140? do you have regualar monthly bleeding?
I HAVE BEEN ON THIS PATCH FOR ABOUT A YEAR AND THEY TRULY HELP WITH MENOPAUSE SYMPTONS BUT I BLEED EVERY MONTH LIKE A REGULAR PERIOD AND I AM TIRED OF THIS, IS THIS NORMAL, I CAN NEVER GET A STRAIGHT ANSWER FROM MY DOCTOR,, SO LADIES ANY HELP WOULD BE APPRECIATED VERY MUCH AND CAN YOU JUST STOP USING THE PATCHS IF... Asked by Xiao Willame 1 year ago.

I HAVE BEEN ON THIS PATCH FOR ABOUT A YEAR AND THEY TRULY HELP WITH MENOPAUSE SYMPTONS BUT I BLEED EVERY MONTH LIKE A REGULAR PERIOD AND I AM TIRED OF THIS, IS THIS NORMAL, I CAN NEVER GET A STRAIGHT ANSWER FROM MY DOCTOR,, SO LADIES ANY HELP WOULD BE APPRECIATED VERY MUCH AND CAN YOU JUST STOP USING THE PATCHS IF YOU WANT TO OR DO YOU HAVE TO BE WEANED OFF THEM?? THANKS FOR ANY HELP Answered by Rickie Trippet 1 year ago.

Combi Patch Answered by Desire Vendela 1 year ago.

Hilarious. # Answered by Lilian Lapatra 1 year ago.


Which is better for HRT PREMPRO or COMBIPATCH?
I switch my hormon replacment terapy from Prempro to a Combipatch (Estalis) by NOVARTIS , Is anyone uot there with any suggestion or experience any side effects? Thank you. Pina Asked by Levi Coghill 1 year ago.

Both contains hormones estrogen and progesterone in different forms. Which is better depends on your personal preference. Premarin is a oral form that requires daily intake. So, you need to take that every day. If you don't mind taking medication on daily basis and does not get much side effect from taking it, it's a good choice. There is some controversies with the estrogen form used in Prempro - it uses Premarin, which has some studies suggesting possibly increasing heart disease and breast cancer. That does not mean the other forms (including Estrodiol used in Combivent) does not have the same risk, but there are some possibility for sure with Premarin. Combivent uses Eestrodiol, which some physicians prefer due to the studies (or lack of studies). The main advantage is that it is applied monthly. However, it is a skin application, and the patch sometimes can cause skin irritation after long time of application. Answered by Caterina Loecken 1 year ago.


Problems with hrt?
Asked by Jamie Witzel 1 year ago.

The problems with conventional hormone replacement therapy (HRT) Women are rarely informed of all the possible problems with HRT. To start with...No one in their right mind would think of taking a sophisticated jet aircraft in flight and entering alien commands into its computer control system. Yet it seems that conventional HRT does the equivalent of this process when given to a number of women. Alien (and therefore unpredictable and unknown) commands are entered into the endocrine or main "computer control system" of her body through the drugs inaccurately called "hormones" used in HRT. Description of Conventional "Hormone" Replacement Premarin (also called conjugated estrogens) is a word composed from Pregnant Mare's Urine. This horse estrogen is the most commonly prescribed estrogen in the world. It is also the form of estrogen most commonly used in research, including taxpayer funded research. This means that most of what we think we know about "estrogen replacement" in women is actually about horse estrogen "replacement" in humans. It is as yet unclear why studies aren't being done on the inexpensive and easily available bio-indentical human estrogen. The Problems with Premarin heavy menstrual bleeding, cramping breast tenderness fluid retention, edema, weight gain, increased fat headache, migraine depression, anxiety glucose intolerance, insulin resistance estrogen dominance stimulates growth of fibroids worsens endometriosis nausea, vomiting, cramping, bloating leg cramps eye problems high blood pressure increased blood clotting venous thromboembolism increased risk of endometrial and breast cancer loss of scalp hair, growth of facial and body hair gall bladder disease pancreatitis The composition of horse estrogen is vastly different from human estrogen. The metabolic breakdown products of Premarin are biologically stronger and more active than the original equine estrogens. Various studies have shown that these breakdown products can produce DNA damage that is cancer-causing. So, for example, the incidence of breast cancer increases when women take Premarin. Premarin, like all conventional HRT, is prescribed in standard dosages and not tailored to individual requirements. This usually means women are often taking more "estrogen" that they need. It takes about eight weeks to clear Premarin out of the body. In contrast, natural hormones are completely metabolized and cleared in 6-12 hours. Premarin can easily, and usually does, throw a woman into Estrogen Dominance. It causes an excessive increase in Sex Hormone Binding Globulin(SHBG), which in turn blocks thyroid hormone function. Other forms of estrogen used in conventional HRT Note: The list of side effects of synthetic estrogens are similar to those of Premarin. The following lists some of the most commonly prescribed estrogens in HRT: Estraderm, Climara, FemPatch, Menorest, Alora, Esclim, Vivelle-Dot/Vivelle: Patches applied 1-2 times a week. Contain 17 beta-estradiol, a natural(bioidentical)part of estrogen(without its natural partners, estrone and estriol> Estrace: Natural(bio-identical) micronized estradiol in oral form. Tri-Estrogen: 10% estrone, 10% estradiol, 80% estriol, in all natural (bioidentical)oral form. Bi-Estrogen: 20% estradiol, 80% estriol, in natural(bioidentical)oral form. Estinyl, Ogen, Ortho-Est, Estratab, Menest, Cenestin: Various versions of synthetic estrogens and synthetic horse estrogens.(Can you believe it?) Premphase, Prempro, Ortho-Prefest, FemRt, CombiPatch: Various forms of synthetic partial or horse estrogens, plus progestins(synthetic). Tri-Est plus OMP(oral micronized progesterone): 10% estrone, 10% estradiol, 80% estriol, plus 100 mg OMP. Estratest: Synthetic estrogen plus synthetic testosterone. Progestins are chemical or drug imitations of progesterone, with disturbing side effects. Provera(medroxyprogesterone acetate)is the most common progestin. It is also used in PremPro, which is Premarin and Provera in combination. Most progestins are made by taking natural progesterone and altering the chemical structure so it can be patented. Another type of progestin is made by altering a synthetic form of testosterone. Problems with progestins They suppress production of natural progesterone in the body. They disrupt the steroid hormone pathways, which can cause both immediate and/or insidious undermining of both adrenal and gonadal function. Since a steroid hormone pathway is fundamental to energy and vitality, these drugs are usually a prescription for chronic fatigue(and probably fibromyalgia). This is not conventionally recognized. The myriad of side effects. Side Effects of Progestins depression anxiety, nervousness fatigue, leading to chronic fatigue over time fluid retention and breast tenderness, weight gain migraine coronary artery spasm angina, palpitations menstrual irregularities, spotting glucose intolerance; promotes insulin resistance general edema nausea insomnia, sleepiness skin rashes, acne hair loss on scalp, facial hair growth Possible life-threatening adverse effects of progestins Coronary spasm-This is most significant: 90% of men who have heart attacks have atherosclerosis or obstruction of coronary arteries, but only 30% of women do. The majority of women who have heart attacks do so because of coronary artery spasm. Stroke Pulmonary embolism Implicated in causing breast cancer. Other disturbing potential problems with progestins The PDR(Physician's Desk Reference) advises patients to discontinue this drug if there is a sudden or partial loss of vision. Liver disease Increases the risk of birth defects(remember, progestins are in all oral contraceptives). Gall bladder disease The 2001 PDR states this about progestins: "The effect of prolonged use of this drug on pituitary, ovarian, adrenal, hepatic or uterine functions is unknown". It needs to be emphasized that natural progesterone has NONE of these side effects. In fact, natural progesterone protects against many of the problems progestins cause. Consider, for example, that one of progesterone's important functions is to protect and maintain pregnancy, while progestins are contraindicated in pregnancy because of potentially disastrous consequences to the fetus. And finally, it is common for health professionals not to know that progestins and progesterone are not the same thing. The following lists the most commonly prescribed progestins, and two prescription natural progesterones: Provera, Amen, Cycrin: Various brands of oral medroxyprogesterone(MPA), a progestin(synthetic). Aygestin, Micronor, Norlutin, Norlutate: Various brands of oral norethindrone acetate, a progestin(synthetic). Prometrium, OMP(Oral Micronized Progesterone): Two brands of oral natural progesterone Recent discoveries about conventional HRT Cardiovascular protection Cardiovascular disease is the number one cause of death in postmenopausal women. For decades it has been assumed that estrogen conferred cardiovascular protection that is lost at menopause. Premarin (and other drug forms of estrogen) has been routinely prescribed for postmenopausal heart protection, based on this assumption. In the last few years many studies have challenged this assumption. Here are a few examples: HERS-Heart and Estrogen/Progesterone Replacement Study-This large study of women with existing heart disease found that "hormone replacement" in the form of Premarin and Provera did not decrease their risk of subsequent heart attack, but actually increased it significantly during the first year of use. Women's Health Initiative is a taxpayer-funded study of thousands of women on Premarin (and sometimes Provera), which found that these "hormones" did not demonstrate protection against heart attack or other cardiovascular problems. The 1997 Postmenopausal Estrogen/Progestin Intervention(PEPI) trial, a long term prospective study conducted by the National Institute of Health(NIH), assessed the effects of "hormone replacement therapy" for Premarin, Provera, and natural progesterone on bone and cardiovascular health. Reported in the Journal of the American Medical Association, this study showed that Premarin raised HDL levels, a possible cardiovascular protective effect, but when Provera was added, the effect was totally nullified. Natural progesterone did not nullify the possible protective effect. Note: An interesting observation about this study: Although both estrogen and either progestin or progesterone was given to all participants, the significant gain in bone density was attributed entirely to estrogen by the AMA press-release. An excerpt from "The Greatest Experiment Ever Performed To Women Exploding the Estrogen Myth" "In June 2002, a large, randomized study of synthetic estrogen was stopped early because the risks to the postmenopausal women involved were outweighing the benefits, and many women who had been taking estrogen for years were left confused and angry. Seaman, a veteran women's health journalist (The Doctor's Case Against the Pill; Women and the Crisis in Sex Hormones), reminds readers that these findings are just the latest twist in the long and fascinating history of estrogen therapy. Seaman offers an explanation of how the estrogen drug Premarin was developed in the 1930s and then broadly marketed and prescribed to treat menopausal symptoms for the next five decades, despite the known increased risk of endometrial and breast cancer. She describes the historical roles played by different researchers, government officials. Seaman concludes with a chapter on environmental estrogens and an appendix on practical information on menopausal women's treatment options, including supplements. Seaman passionately and convincingly argues that women have been unnecessarily put at risk by doctors treating menopause as a disease." This sort of arbitrary and questionable interpretation is often found in research studies. The Nurse's Questionnaire Study-reported in The New England Journal of Medicine in 1991 documented a nearly 50% increase in strokes among HRT users. (It is fascinating to note that while their data recorded that fact, the authors stated that current estrogen use "...is not associated with any change in risk of stroke.") Hormone Therapy Linked to Dementia The Problems With Oral And Injected Contraceptives General considerations: AKA The Pill, oral contraceptives come in a variety of mixtures of low-dose estrogen and progestin, or sometimes just progestin. Considered a "safe" form of contraception, the risks involved are often ignored or minimized. Oral contraceptives are also given routinely by conventional medical practitioners for PMS and many other female hormonal problems, supposedly to "regulate" the female cycle. Oral contraceptives work by "fooling" the endocrine system and preventing the normal female cycle and ovulation from occurring. This, of course, is not the same as regulation. In fact, the concept that you can "regulate" the enormously complex and delicately balanced Hormonal Control System of the body by "fooling" and disrupting it with "drug hormones" whose consequences, especially long term, are only vaguely understood, is a peculiar form of insanity. After stopping the pill, it takes varying lengths of time, from one month to many months, to reestablish a normal cycle. Another version of synthetic hormone contraception is the time-released shot, which lasts for three months. Examples are Norplant and Depo-Provera. This form usually has much more severe side-effects. Some of the known risks from oral contraceptives For many women it will participate in precipitating chronic fatigue/fibromyalgia over time. Increased risk of blood clots. Increased risk of stroke Increased risk of high blood pressure Increased risk of heart attack. Increased risk of cervical dysplasia, ovarian cysts and infertility. Increased risk of ovarian, breast and uterine cancer. Increased risk of headaches and migraines. Increased risk of immune dysfunction and autoimmune diseases. Increased risk of thyroid and liver problems and cancers. Reduced antioxidant levels, especially in the liver. Nutritional deficiences, especially Folic Acid, B12, B6 and other B complex vitamins, Magnesium, Manganese, Zinc and Vitamin A. Increased risk of gall bladder problems Increases risk of other endocrine disorders. Increased risk of loss of libido. Increased risk of mental and emotional side effects. Increased anti-anxiety, anti-depressant, or sleeping pill usage. Higher rate of birth defects and birth marks in offspring. Interferes with copper in the body, eventualy causing copper toxicity. Contributes to Estrogen Dominance. Interferes with steroid hormone balance. Natural Alternatives to HRT Many women choose not to use HRT. If you don’t want to take or cannot take HRT, there are other options available. For example, if osteoporosis is a concern, there are other drugs that are used to prevent and treat it. If vaginal dryness is a problem, there are many types of lubricants that can be helpful. A healthy lifestyle is important whether you use HRT or not. Here are some ways to stay healthy and feel well through menopause and beyond. Eat healthy foods. Your diet should be low in fat, rich in fruits and vegetables, and provide adequate calcium and vitamin D. A multivitamin and calcium supplement may be helpful. Get regular exercise. Try to get at least 30 minutes of exercise most days of the week. Don’t smoke. Use alcohol in moderation, if at all. What about herbal remedies and other alternatives? Some women turn to herbal remedies or to certain estrogen-like chemicals in plants (called phytoestrogens) for help. These products are not regulated through the same government system as drugs are. There is limited and conflicting research on their safety and effectiveness. Some of the herbal products can have harmful side effects or can interact with other drugs. Discover the function and the name of herbs commonly used for female health issues in our Herbal Allies: Introduction to Herbs. Discuss herbal remedies with a qualified healthcare provider before taking them, but do not summarily dismiss them because a medical practitioner has limited knowledge. There are some products that seem to help some women. Soy and soy products are high in phytoestrogens and may help with menopausal symptoms. The evidence regarding soy is conflicting, however. Clinical studies have shown that soy has little estrogenic activity in the brain and, therefore, doesn't help greatly with hot flashes and night sweats. In breast tissue, soy may stimulate the growth of breast cells and thus large amounts of soy may not be advised for breast cancer patients. Although phytoestrogens have some estrogenic activity and may have some of the same effects as HRT, their long-term safety is not clear and has not been adequately studied. Studies of black cohosh have found that it may reduce hot flashes and night sweats for some women. St. John’s Wort and chasteberry may help some women with depressed mood. Some recent studies comparing specific herbal products to placebo in controlled clinical trials have shown little or no effect for ginseng, dong quai, evening primrose oil, and red clover products on menopausal symptoms. However, there is a long tradition of the use of these and other herbal remedies in menopause. Learn more about natural approaches which can be used instead of, or in conjunction with, conventional hormone therapy in our Remedies for Menopausal Symptoms. Natural Alternatives for Menopause Bioidentical Progesterone Cream with Phytoestrogens Contains both progesterone and phytoestrogens which work together to provide women more effective control of their menopausal symptoms. Menopause Formula (PhytoBalance) PhytoBalance contains eight of the most tested and proven herbs that reduces hot flashes, night sweats, mood swings, irritability, and depression associated with perimenopause and menopause. Recommended Herbs Menopause-Condition Treatments Answered by Dennis Rajan 1 year ago.

You haven't provided enough information for an answer. You need to say what kind of HRT you are on. Dosage and name? And what your periods were like before the HRT also. But what I'm guessing is that you have uterine fibroids, and the HRT is making them grow and that's why you have painful bleeding. That's why women with fibroids often don't take HRT. Answered by Salvador Timber 1 year ago.


Menopause....?
What were your symptoms? Did you experience severe headaches? Did your headaches or hot flashes wake you up at night? Did they occur only at night, most of the time, and at the same time (like if it were an alarm)? Asked by Jillian Schomburg 1 year ago.

oh honey headaches and hot flashs is just the beginning. i hate to tell you this but it could get worse. i;m just being honest with you not trying to worry you. i have done a lot of research on menopause and some women have it worse than others, i have it worse though. i'v had 2 or 3 hot flashes in 1 hour. this went on for a long time, mood swings so bad i couldn't even stand my ownself much less my family. it was horrible, i was irratiable all the time never felt good, never slept good, appetite comes and goes. well i could go on and on but, i hope and pray you don't have these symptoms as bad as i do. i finally started taking the combipatchs twice a week and a feel a lot better. i hated to use hormon therapy, but it does give me some relief, last week i asked my dr. how much longer am i gonna go thru this and his said maybe forever. i left crying that day. but some women have it a few yrs and others have it for yrs and yrs and yrs. my sympthay for you. i hope you do alright, take care my friend Answered by Kristian Daisy 1 year ago.

All of the above! Also, profound memory loss (almost like Alzheimers) and violent mood swings. An estrogen supplement has provided amazing relief. Also, for some people, a soy supplement, such as Estroven or NewPhase, helps immensely. . Answered by Neida Yelverton 1 year ago.

Hahahaha chortle chortle hahaha hehehehehe deep breath hahahahahehehehe eyes are watering, needed to wipe my nostril. That is sooo humorous!!! I get wherein you had been coming from. That hotflash have got to had been a doozie!!! Been there performed that and that and that..... gram Answered by Sheba Desilva 1 year ago.


Menopause help? does anyone use the combipatch 50/140? do you have regualar monthly bleeding?
I HAVE BEEN ON THIS PATCH FOR ABOUT A YEAR AND THEY TRULY HELP WITH MENOPAUSE SYMPTONS BUT I BLEED EVERY MONTH LIKE A REGULAR PERIOD AND I AM TIRED OF THIS, IS THIS NORMAL, I CAN NEVER GET A STRAIGHT ANSWER FROM MY DOCTOR,, SO LADIES ANY HELP WOULD BE APPRECIATED VERY MUCH AND CAN YOU JUST STOP USING THE PATCHS IF... Asked by Mana Goodman 1 year ago.

I HAVE BEEN ON THIS PATCH FOR ABOUT A YEAR AND THEY TRULY HELP WITH MENOPAUSE SYMPTONS BUT I BLEED EVERY MONTH LIKE A REGULAR PERIOD AND I AM TIRED OF THIS, IS THIS NORMAL, I CAN NEVER GET A STRAIGHT ANSWER FROM MY DOCTOR,, SO LADIES ANY HELP WOULD BE APPRECIATED VERY MUCH AND CAN YOU JUST STOP USING THE PATCHS IF YOU WANT TO OR DO YOU HAVE TO BE WEANED OFF THEM?? THANKS FOR ANY HELP Answered by Magaly Romanoff 1 year ago.

Combi Patch Answered by Danyel Sauveur 1 year ago.

Hilarious. # Answered by Yaeko Winklepleck 1 year ago.


Which is better for HRT PREMPRO or COMBIPATCH?
I switch my hormon replacment terapy from Prempro to a Combipatch (Estalis) by NOVARTIS , Is anyone uot there with any suggestion or experience any side effects? Thank you. Pina Asked by Darron Fuller 1 year ago.

Both contains hormones estrogen and progesterone in different forms. Which is better depends on your personal preference. Premarin is a oral form that requires daily intake. So, you need to take that every day. If you don't mind taking medication on daily basis and does not get much side effect from taking it, it's a good choice. There is some controversies with the estrogen form used in Prempro - it uses Premarin, which has some studies suggesting possibly increasing heart disease and breast cancer. That does not mean the other forms (including Estrodiol used in Combivent) does not have the same risk, but there are some possibility for sure with Premarin. Combivent uses Eestrodiol, which some physicians prefer due to the studies (or lack of studies). The main advantage is that it is applied monthly. However, it is a skin application, and the patch sometimes can cause skin irritation after long time of application. Answered by Marlo Swearengen 1 year ago.


Problems with hrt?
Asked by Lucile Dardis 1 year ago.

The problems with conventional hormone replacement therapy (HRT) Women are rarely informed of all the possible problems with HRT. To start with...No one in their right mind would think of taking a sophisticated jet aircraft in flight and entering alien commands into its computer control system. Yet it seems that conventional HRT does the equivalent of this process when given to a number of women. Alien (and therefore unpredictable and unknown) commands are entered into the endocrine or main "computer control system" of her body through the drugs inaccurately called "hormones" used in HRT. Description of Conventional "Hormone" Replacement Premarin (also called conjugated estrogens) is a word composed from Pregnant Mare's Urine. This horse estrogen is the most commonly prescribed estrogen in the world. It is also the form of estrogen most commonly used in research, including taxpayer funded research. This means that most of what we think we know about "estrogen replacement" in women is actually about horse estrogen "replacement" in humans. It is as yet unclear why studies aren't being done on the inexpensive and easily available bio-indentical human estrogen. The Problems with Premarin heavy menstrual bleeding, cramping breast tenderness fluid retention, edema, weight gain, increased fat headache, migraine depression, anxiety glucose intolerance, insulin resistance estrogen dominance stimulates growth of fibroids worsens endometriosis nausea, vomiting, cramping, bloating leg cramps eye problems high blood pressure increased blood clotting venous thromboembolism increased risk of endometrial and breast cancer loss of scalp hair, growth of facial and body hair gall bladder disease pancreatitis The composition of horse estrogen is vastly different from human estrogen. The metabolic breakdown products of Premarin are biologically stronger and more active than the original equine estrogens. Various studies have shown that these breakdown products can produce DNA damage that is cancer-causing. So, for example, the incidence of breast cancer increases when women take Premarin. Premarin, like all conventional HRT, is prescribed in standard dosages and not tailored to individual requirements. This usually means women are often taking more "estrogen" that they need. It takes about eight weeks to clear Premarin out of the body. In contrast, natural hormones are completely metabolized and cleared in 6-12 hours. Premarin can easily, and usually does, throw a woman into Estrogen Dominance. It causes an excessive increase in Sex Hormone Binding Globulin(SHBG), which in turn blocks thyroid hormone function. Other forms of estrogen used in conventional HRT Note: The list of side effects of synthetic estrogens are similar to those of Premarin. The following lists some of the most commonly prescribed estrogens in HRT: Estraderm, Climara, FemPatch, Menorest, Alora, Esclim, Vivelle-Dot/Vivelle: Patches applied 1-2 times a week. Contain 17 beta-estradiol, a natural(bioidentical)part of estrogen(without its natural partners, estrone and estriol> Estrace: Natural(bio-identical) micronized estradiol in oral form. Tri-Estrogen: 10% estrone, 10% estradiol, 80% estriol, in all natural (bioidentical)oral form. Bi-Estrogen: 20% estradiol, 80% estriol, in natural(bioidentical)oral form. Estinyl, Ogen, Ortho-Est, Estratab, Menest, Cenestin: Various versions of synthetic estrogens and synthetic horse estrogens.(Can you believe it?) Premphase, Prempro, Ortho-Prefest, FemRt, CombiPatch: Various forms of synthetic partial or horse estrogens, plus progestins(synthetic). Tri-Est plus OMP(oral micronized progesterone): 10% estrone, 10% estradiol, 80% estriol, plus 100 mg OMP. Estratest: Synthetic estrogen plus synthetic testosterone. Progestins are chemical or drug imitations of progesterone, with disturbing side effects. Provera(medroxyprogesterone acetate)is the most common progestin. It is also used in PremPro, which is Premarin and Provera in combination. Most progestins are made by taking natural progesterone and altering the chemical structure so it can be patented. Another type of progestin is made by altering a synthetic form of testosterone. Problems with progestins They suppress production of natural progesterone in the body. They disrupt the steroid hormone pathways, which can cause both immediate and/or insidious undermining of both adrenal and gonadal function. Since a steroid hormone pathway is fundamental to energy and vitality, these drugs are usually a prescription for chronic fatigue(and probably fibromyalgia). This is not conventionally recognized. The myriad of side effects. Side Effects of Progestins depression anxiety, nervousness fatigue, leading to chronic fatigue over time fluid retention and breast tenderness, weight gain migraine coronary artery spasm angina, palpitations menstrual irregularities, spotting glucose intolerance; promotes insulin resistance general edema nausea insomnia, sleepiness skin rashes, acne hair loss on scalp, facial hair growth Possible life-threatening adverse effects of progestins Coronary spasm-This is most significant: 90% of men who have heart attacks have atherosclerosis or obstruction of coronary arteries, but only 30% of women do. The majority of women who have heart attacks do so because of coronary artery spasm. Stroke Pulmonary embolism Implicated in causing breast cancer. Other disturbing potential problems with progestins The PDR(Physician's Desk Reference) advises patients to discontinue this drug if there is a sudden or partial loss of vision. Liver disease Increases the risk of birth defects(remember, progestins are in all oral contraceptives). Gall bladder disease The 2001 PDR states this about progestins: "The effect of prolonged use of this drug on pituitary, ovarian, adrenal, hepatic or uterine functions is unknown". It needs to be emphasized that natural progesterone has NONE of these side effects. In fact, natural progesterone protects against many of the problems progestins cause. Consider, for example, that one of progesterone's important functions is to protect and maintain pregnancy, while progestins are contraindicated in pregnancy because of potentially disastrous consequences to the fetus. And finally, it is common for health professionals not to know that progestins and progesterone are not the same thing. The following lists the most commonly prescribed progestins, and two prescription natural progesterones: Provera, Amen, Cycrin: Various brands of oral medroxyprogesterone(MPA), a progestin(synthetic). Aygestin, Micronor, Norlutin, Norlutate: Various brands of oral norethindrone acetate, a progestin(synthetic). Prometrium, OMP(Oral Micronized Progesterone): Two brands of oral natural progesterone Recent discoveries about conventional HRT Cardiovascular protection Cardiovascular disease is the number one cause of death in postmenopausal women. For decades it has been assumed that estrogen conferred cardiovascular protection that is lost at menopause. Premarin (and other drug forms of estrogen) has been routinely prescribed for postmenopausal heart protection, based on this assumption. In the last few years many studies have challenged this assumption. Here are a few examples: HERS-Heart and Estrogen/Progesterone Replacement Study-This large study of women with existing heart disease found that "hormone replacement" in the form of Premarin and Provera did not decrease their risk of subsequent heart attack, but actually increased it significantly during the first year of use. Women's Health Initiative is a taxpayer-funded study of thousands of women on Premarin (and sometimes Provera), which found that these "hormones" did not demonstrate protection against heart attack or other cardiovascular problems. The 1997 Postmenopausal Estrogen/Progestin Intervention(PEPI) trial, a long term prospective study conducted by the National Institute of Health(NIH), assessed the effects of "hormone replacement therapy" for Premarin, Provera, and natural progesterone on bone and cardiovascular health. Reported in the Journal of the American Medical Association, this study showed that Premarin raised HDL levels, a possible cardiovascular protective effect, but when Provera was added, the effect was totally nullified. Natural progesterone did not nullify the possible protective effect. Note: An interesting observation about this study: Although both estrogen and either progestin or progesterone was given to all participants, the significant gain in bone density was attributed entirely to estrogen by the AMA press-release. An excerpt from "The Greatest Experiment Ever Performed To Women Exploding the Estrogen Myth" "In June 2002, a large, randomized study of synthetic estrogen was stopped early because the risks to the postmenopausal women involved were outweighing the benefits, and many women who had been taking estrogen for years were left confused and angry. Seaman, a veteran women's health journalist (The Doctor's Case Against the Pill; Women and the Crisis in Sex Hormones), reminds readers that these findings are just the latest twist in the long and fascinating history of estrogen therapy. Seaman offers an explanation of how the estrogen drug Premarin was developed in the 1930s and then broadly marketed and prescribed to treat menopausal symptoms for the next five decades, despite the known increased risk of endometrial and breast cancer. She describes the historical roles played by different researchers, government officials. Seaman concludes with a chapter on environmental estrogens and an appendix on practical information on menopausal women's treatment options, including supplements. Seaman passionately and convincingly argues that women have been unnecessarily put at risk by doctors treating menopause as a disease." This sort of arbitrary and questionable interpretation is often found in research studies. The Nurse's Questionnaire Study-reported in The New England Journal of Medicine in 1991 documented a nearly 50% increase in strokes among HRT users. (It is fascinating to note that while their data recorded that fact, the authors stated that current estrogen use "...is not associated with any change in risk of stroke.") Hormone Therapy Linked to Dementia The Problems With Oral And Injected Contraceptives General considerations: AKA The Pill, oral contraceptives come in a variety of mixtures of low-dose estrogen and progestin, or sometimes just progestin. Considered a "safe" form of contraception, the risks involved are often ignored or minimized. Oral contraceptives are also given routinely by conventional medical practitioners for PMS and many other female hormonal problems, supposedly to "regulate" the female cycle. Oral contraceptives work by "fooling" the endocrine system and preventing the normal female cycle and ovulation from occurring. This, of course, is not the same as regulation. In fact, the concept that you can "regulate" the enormously complex and delicately balanced Hormonal Control System of the body by "fooling" and disrupting it with "drug hormones" whose consequences, especially long term, are only vaguely understood, is a peculiar form of insanity. After stopping the pill, it takes varying lengths of time, from one month to many months, to reestablish a normal cycle. Another version of synthetic hormone contraception is the time-released shot, which lasts for three months. Examples are Norplant and Depo-Provera. This form usually has much more severe side-effects. Some of the known risks from oral contraceptives For many women it will participate in precipitating chronic fatigue/fibromyalgia over time. Increased risk of blood clots. Increased risk of stroke Increased risk of high blood pressure Increased risk of heart attack. Increased risk of cervical dysplasia, ovarian cysts and infertility. Increased risk of ovarian, breast and uterine cancer. Increased risk of headaches and migraines. Increased risk of immune dysfunction and autoimmune diseases. Increased risk of thyroid and liver problems and cancers. Reduced antioxidant levels, especially in the liver. Nutritional deficiences, especially Folic Acid, B12, B6 and other B complex vitamins, Magnesium, Manganese, Zinc and Vitamin A. Increased risk of gall bladder problems Increases risk of other endocrine disorders. Increased risk of loss of libido. Increased risk of mental and emotional side effects. Increased anti-anxiety, anti-depressant, or sleeping pill usage. Higher rate of birth defects and birth marks in offspring. Interferes with copper in the body, eventualy causing copper toxicity. Contributes to Estrogen Dominance. Interferes with steroid hormone balance. Natural Alternatives to HRT Many women choose not to use HRT. If you don’t want to take or cannot take HRT, there are other options available. For example, if osteoporosis is a concern, there are other drugs that are used to prevent and treat it. If vaginal dryness is a problem, there are many types of lubricants that can be helpful. A healthy lifestyle is important whether you use HRT or not. Here are some ways to stay healthy and feel well through menopause and beyond. Eat healthy foods. Your diet should be low in fat, rich in fruits and vegetables, and provide adequate calcium and vitamin D. A multivitamin and calcium supplement may be helpful. Get regular exercise. Try to get at least 30 minutes of exercise most days of the week. Don’t smoke. Use alcohol in moderation, if at all. What about herbal remedies and other alternatives? Some women turn to herbal remedies or to certain estrogen-like chemicals in plants (called phytoestrogens) for help. These products are not regulated through the same government system as drugs are. There is limited and conflicting research on their safety and effectiveness. Some of the herbal products can have harmful side effects or can interact with other drugs. Discover the function and the name of herbs commonly used for female health issues in our Herbal Allies: Introduction to Herbs. Discuss herbal remedies with a qualified healthcare provider before taking them, but do not summarily dismiss them because a medical practitioner has limited knowledge. There are some products that seem to help some women. Soy and soy products are high in phytoestrogens and may help with menopausal symptoms. The evidence regarding soy is conflicting, however. Clinical studies have shown that soy has little estrogenic activity in the brain and, therefore, doesn't help greatly with hot flashes and night sweats. In breast tissue, soy may stimulate the growth of breast cells and thus large amounts of soy may not be advised for breast cancer patients. Although phytoestrogens have some estrogenic activity and may have some of the same effects as HRT, their long-term safety is not clear and has not been adequately studied. Studies of black cohosh have found that it may reduce hot flashes and night sweats for some women. St. John’s Wort and chasteberry may help some women with depressed mood. Some recent studies comparing specific herbal products to placebo in controlled clinical trials have shown little or no effect for ginseng, dong quai, evening primrose oil, and red clover products on menopausal symptoms. However, there is a long tradition of the use of these and other herbal remedies in menopause. Learn more about natural approaches which can be used instead of, or in conjunction with, conventional hormone therapy in our Remedies for Menopausal Symptoms. Natural Alternatives for Menopause Bioidentical Progesterone Cream with Phytoestrogens Contains both progesterone and phytoestrogens which work together to provide women more effective control of their menopausal symptoms. Menopause Formula (PhytoBalance) PhytoBalance contains eight of the most tested and proven herbs that reduces hot flashes, night sweats, mood swings, irritability, and depression associated with perimenopause and menopause. Recommended Herbs Menopause-Condition Treatments Answered by Larraine Dinnendahl 1 year ago.

You haven't provided enough information for an answer. You need to say what kind of HRT you are on. Dosage and name? And what your periods were like before the HRT also. But what I'm guessing is that you have uterine fibroids, and the HRT is making them grow and that's why you have painful bleeding. That's why women with fibroids often don't take HRT. Answered by Annie Tarlow 1 year ago.


Menopause....?
What were your symptoms? Did you experience severe headaches? Did your headaches or hot flashes wake you up at night? Did they occur only at night, most of the time, and at the same time (like if it were an alarm)? Asked by Victor Kelsch 1 year ago.

oh honey headaches and hot flashs is just the beginning. i hate to tell you this but it could get worse. i;m just being honest with you not trying to worry you. i have done a lot of research on menopause and some women have it worse than others, i have it worse though. i'v had 2 or 3 hot flashes in 1 hour. this went on for a long time, mood swings so bad i couldn't even stand my ownself much less my family. it was horrible, i was irratiable all the time never felt good, never slept good, appetite comes and goes. well i could go on and on but, i hope and pray you don't have these symptoms as bad as i do. i finally started taking the combipatchs twice a week and a feel a lot better. i hated to use hormon therapy, but it does give me some relief, last week i asked my dr. how much longer am i gonna go thru this and his said maybe forever. i left crying that day. but some women have it a few yrs and others have it for yrs and yrs and yrs. my sympthay for you. i hope you do alright, take care my friend Answered by Mario Nimmer 1 year ago.

All of the above! Also, profound memory loss (almost like Alzheimers) and violent mood swings. An estrogen supplement has provided amazing relief. Also, for some people, a soy supplement, such as Estroven or NewPhase, helps immensely. . Answered by Leonida Eitniear 1 year ago.

Hahahaha chortle chortle hahaha hehehehehe deep breath hahahahahehehehe eyes are watering, needed to wipe my nostril. That is sooo humorous!!! I get wherein you had been coming from. That hotflash have got to had been a doozie!!! Been there performed that and that and that..... gram Answered by Treasa Klingen 1 year ago.


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