Application Information

This drug has been submitted to the FDA under the reference 203976/001.

Names and composition

"COLCHICINE" is the commercial name of a drug composed of COLCHICINE.
It belongs to the class Gout treatments and is used in Gout (Musculoskeletal Disorders)

Answered questions

My doctor has told me to take colchicine for three months. Is this safe?
This medicine is being taken for gout. I also have chronic kidney deisease with a kidney function of 30%. Asked by Irmgard Capo 5 months ago.

Colchicine is a poison (look for Colchicine side effects with an internet search) and should be taken only when the gout pain gets so severe that you are willing to take this poison to break up the uric acid crystals that bring you the pain. It is effective in breaking up the crystals and relieving the pain, but it will make you nauseous. You are prone to gout attacks because of your compromised kidney function. You should try to control the gout trough diet first, natural herbs second, and colchicine as a last resort. Check out and a product called Gout Cleanse by Bioneutrix. I have a friend with kidney disease that takes both of these products with great success. He still occaisionally has to resort to taking Colchicine because he chooses to sometimes eat all the wrong foods and suffers the consequences with gout. I can't believe he would choose ever to be in that kind of pain again when he can control it with the foods he eats. The site will tell you what kind of foods to avoid and which foods are healing foods. The healing foods that I remember are almonds, corn, potatoes, and brown rice. My friend has also discovered that his gout attacks are triggered by sluggish bowels. If his bowels are regular, he doesn't have an attack. If he gets constipated, the uric acid builds in his blood and the crystals form in his joints. Answered by Meredith Borlace 5 months ago.

A truly amazing question! The questioner just gets medication for gout, has chronic kidney disease with low function and comes to Yahoo! Answers to ask about safety? The people you should ask is you doctor and your pharmacist! Instead of wasting time in here go do a search on Colchicine and read about the kidney cell damage that can occur and how it should be avoided if one suffers from low kidney function!!! Answered by Nisha Cronkhite 5 months ago.

Well, it will definitely work for your gout and you will be more than glad to take it. I think you will find the benefit of taking Colchicine will out-way the side effects. I do know diarrhea is a more common side effect but I would take it and get over the pain and flare up of this bout with gout! Answered by Tari Tremore 5 months ago.

Colchicine can be used for prophylactic therapy. However, it is not recommended in patients with a creatinine clearance of <50ml/min. Talk to your doctor about using allopurinol, which will need be dose adjusted for renal impairment, for prophylactic therapy and colchicine for just acute attacks. Answered by Shad Loux 5 months ago.

does he know that you have kidney disease? if so, then it's probably safe. Answered by Michele Stumbo 5 months ago.

If your doctor prescribed it; it has to be safe! Answered by Elbert Aldrige 5 months ago.

What is the role of colchicine in chromosome investigation?
Asked by Coral Falor 5 months ago.

Colchicine inhibits microtubule polymerization by binding to tubulin, one of the main constituents of microtubules. Availability of tubulin is essential to mitosis, and therefore colchicine effectively functions as a "mitotic poison" or spindle poison. The mitosis inhibiting function of colchicine has been of great use in the study of cellular genetics. To see the chromosomes of a cell under a light microscope, it is important that they be viewed near the point in the cell cycle in which they are most dense. This occurs near the middle of mitosis, so mitosis must be stopped before it completes. Adding colchicine to a culture during mitosis is part of the standard procedure for doing karyotype studies. Answered by Winnifred Kohlmeier 5 months ago.

Why do scientists use colchicine to produce a seedless triploid?
actually, what i really want to know is, why do scientists use colchicine? what does it do? Asked by Mike Bonar 5 months ago.

When colchicine is applied to cells, they replicate their DNA but get stuck in mitosis: they can't separate the DNA into daughter cells because the microtubules that make up the spindles can't form. So instead, they eventually "give up" and go back to G1 with twice as much DNA as they started with. Once the colchicine is washed off, these cells will be tetraploids. They can produce gametes that are diploid instead of haploid. Say you take a diploid gamete and fuse it artificially with a normal gamete from the same species. You have produced a triploid plant. In many cases it will grow normally (which may surprise you). However, when it tries to produce its own gametes, it will utterly fail. Meiosis I is not designed to divide 3 sets of DNA two ways. Most of the gametes will be incapable of developing after fertilization, and so no seeds will form in the fruit from that plant. Answered by Chu Hutton 5 months ago.

When should Colchicine, given for acute gout, be stopped?
Asked by Carmelia Dipietrantoni 5 months ago.

Gout is a condition where uric acid crystals build up in the body. This can happen in the area of the big toe and cause a lot of pain. Our foods contain purines; some foods are higher in this than others. The doctor may place you on a lower purine diet (of which they will usually provide you a list of foods to avoid. There is also medications that can lower the uric acid in the blood Here an alternative way to cure gout? Answered by Ismael Shearer 5 months ago.

Gout attacks can be controlled or prevented by lifestyle changes and the use of certain medications. To help prevent future attacks, take the gout medications that your doctor prescribes. Carefully follow instructions about how much medicine to take and when to take it. Acute gout is best treated when symptoms first occur. Tell your doctor about all the medicines, dietary supplements, and vitamins you take. He or she can tell you if any of them increase your risk of hyperuricemia. Plan followup visits with your doctor to evaluate your progress. Exercise regularly and maintain a healthy body weight. Lose weight if you are overweight, but do not go on diets designed for quick or extreme loss of weight because they increase uric acid levels in the blood. Answered by Toshia Provosty 5 months ago.

Pharmaceuticals are certainly an option if you are looking for gout treatment. Alleviating gout and symptoms is hard to accomplish, and today’s doctors are quick to prescribe a wide range of drugs to help decrease uric acid levels in your blood. While there is nothing inherently wrong with taking medications, it is important to realize that these drugs can have some pretty major side effects. Another problem is that they really only work to reduce uric acid levels already existing within the body. Go to this website and read the articles. Answered by Toya Maheu 5 months ago.

Do the drugs colchicine and taxol affect microfilaments and intermediate filaments too?
My text book says that the drug colchicine inhibits microtubule assembly and stimulates disassembly and the drug taxol stimulates microtubules assembly. But do these drugs also affect microfilaments and intermediate filaments of the cytoskeleton? Asked by Gertie Tolmich 5 months ago.

Colchicine inhibits microtubules by it's interaction with the protein tubulin, which forms the microtubule. Tubulin is not found in the micro- and intermediate filaments so colchicine does not affect them. Taxol stabilises the microtubule structure, this makes the microtubules inflexible and the cell cannot use them (cannot extend and retract them). Taxol works by interacting with tubulin so it also does not have an affect on the other two filaments. Answered by Antonetta Lappin 5 months ago.

Anyone about colchicines?
dis is 4 my research work on biology... Asked by Shirely Dorff 5 months ago.

col·chi·cine (kŏl'chĭ-sēn', kŏl'kĭ-) n. A poisonous, pale-yellow alkaloid, obtained from the autumn crocus and used in plant breeding to induce chromosome doubling and in medicine to treat gout. Answered by Luella Tapanes 5 months ago.

How about a better question. What do you want to know. Look up autumn crocus in gardening books or on the net. Autumn crocus is a flower and the bulb is known to produce colchichine. Answered by Samuel Bertini 5 months ago.

What effect does Colchicine have on mitosis?
Asked by Destiny Gendusa 5 months ago.

Colchicine does not allow microtubule formation by binding to tubulin. Tubulin is essential to mitosis, so colchicine messes up mitosis by keeping the spindles from forming. Answered by Adah Umbright 5 months ago.

How could I get some Colchicine?
Ok...there is a reason I posted in botany...I want it for my ******* plant.So PLEASE TELL ME Where to get some. Asked by Lucio Harbick 5 months ago.

Because some of colchicine's side effects can be very serious, you should discuss with your doctor the good that this medicine can do as well as the risks of using it. Make sure you understand exactly how you are to use it, and follow the instructions carefully, to lessen the chance of unwanted effects. This medicine is available only with your doctor's prescription. Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, colchicine is used in certain patients with the following medical conditions: * Amyloidosis * Behçet's syndrome * Calcium pyrophosphate deposition disease (pseudogout) * Cirrhosis of the liver * Familial Mediterranean fever * Pericarditis * Sarcoid arthritis If you are taking colchicine for any of these conditions, the following information may apply: * For all of these conditions, colchicine is usually given regularly in small amounts to reduce inflammation (preventive treatment). This usually decreases the occurrence of severe attacks or other problems caused by inflammation. * Colchicine is not a cure for these conditions. It will help prevent problems caused by inflammation only as long as you continue to take it. * Some patients with calcium pyrophosphate deposition disease (pseudogout) or familial Mediterranean fever may take larger amounts of colchicine only when an attack occurs, to relieve the attack. For patients taking colchicine for familial Mediterranean fever: * Preventive treatment with colchicine may be helping you even if it does not reduce the number of severe attacks. Colchicine helps prevent other serious problems, such as kidney disease, that can occur in people with this condition. Therefore, even if you think that the colchicine isn't working, do not stop taking it. Check with your doctor instead. Answered by Maurita Effland 5 months ago.

Go to your doctor and see if they will write you a prescription, otherwise you are out of luck. If I remember correctly, it's generally given to arthritus patients. Answered by Yukiko Croslen 5 months ago.

I know you can find it at the online drug store I use, but I am not sure that it will be priced correctly for planting. you can take a look anyway at THE-DRUG-STORE.COM Answered by Sheryll Gaudette 5 months ago.

What is the effect of colchicine and taxol on cells? ?
What is the effect of colchicine and taxol on cells? What will happen specifically to a cell if treated with either drug? Asked by Devin Genter 5 months ago.

Colchicine bonds to tubulin and therefore hinder polymerization of the microtubules. Colchicine stops mitosis in metaphase. Taxol is a microtubule stabilizer. This toxins are used in chemotherapy. Answered by Gertrude Quidley 5 months ago.


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