CAPECITABINE Ressources

Application Information

This drug has been submitted to the FDA under the reference 090943/001.

Names and composition

"CAPECITABINE" is the commercial name of a drug composed of CAPECITABINE.
It belongs to the class 5-FU precursors and is used in Antineoplastics (Cancer)

Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
090943/001 CAPECITABINE CAPECITABINE TABLET/ORAL 150MG
090943/002 CAPECITABINE CAPECITABINE TABLET/ORAL 500MG
091649/001 CAPECITABINE CAPECITABINE TABLET/ORAL 150MG
091649/002 CAPECITABINE CAPECITABINE TABLET/ORAL 500MG
200483/001 CAPECITABINE CAPECITABINE TABLET/ORAL 150MG
200483/002 CAPECITABINE CAPECITABINE TABLET/ORAL 500MG
202593/001 CAPECITABINE CAPECITABINE TABLET/ORAL 150MG
202593/002 CAPECITABINE CAPECITABINE TABLET/ORAL 500MG
204741/001 CAPECITABINE CAPECITABINE TABLET/ORAL 150MG
204741/002 CAPECITABINE CAPECITABINE TABLET/ORAL 500MG
207456/001 CAPECITABINE CAPECITABINE TABLET/ORAL 150MG
207456/002 CAPECITABINE CAPECITABINE TABLET/ORAL 500MG

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
090943/001 CAPECITABINE CAPECITABINE TABLET/ORAL 150MG
090943/002 CAPECITABINE CAPECITABINE TABLET/ORAL 500MG
091649/001 CAPECITABINE CAPECITABINE TABLET/ORAL 150MG
091649/002 CAPECITABINE CAPECITABINE TABLET/ORAL 500MG
200483/001 CAPECITABINE CAPECITABINE TABLET/ORAL 150MG
200483/002 CAPECITABINE CAPECITABINE TABLET/ORAL 500MG
202593/001 CAPECITABINE CAPECITABINE TABLET/ORAL 150MG
202593/002 CAPECITABINE CAPECITABINE TABLET/ORAL 500MG
204741/001 CAPECITABINE CAPECITABINE TABLET/ORAL 150MG
204741/002 CAPECITABINE CAPECITABINE TABLET/ORAL 500MG
207456/001 CAPECITABINE CAPECITABINE TABLET/ORAL 150MG
207456/002 CAPECITABINE CAPECITABINE TABLET/ORAL 500MG
020896/001 XELODA CAPECITABINE TABLET/ORAL 150MG
020896/002 XELODA CAPECITABINE TABLET/ORAL 500MG

Manufacturers

Manufacturer name
Roche Products Ltd

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Answered questions

If I take capecitabine regularly will I lose my fingerprints? How long till this happens?Side affects?
forget about it. to much trouble just to keep from getting arrested because my fingerprints are at the scene of a crime(not that I would break the law mind you). Asked by Toya Dalmida 1 month ago.

Capecitabine, also known as xeloda, is commonly prescribed for head and neck cancers, breast, stomach as well as colorectal cancers to kill the cancer cells. According to the cancer centre, 40 per cent of the patients may develop hand-foot syndrome, with half of them getting more serious side effects such as chronic inflammation of the palms or soles of the feet, leading to peeling, bleeding and blisters. 'This can give rise to eradication of fingerprints with time. 62-year-old Indonesian patient, known only as Mr S to protect his identity, had received chemotherapy for head and neck cancer. Subsequently, he was kept on a low dose of capecitabine to prevent the cancer's recurrence. He developed mild hand-foot syndrome and was not aware that his fingerprints were gone. He had been taking the medicine for more than three years and was on his way to the United States to visit relatives in December last year when he was stopped at the US Customs because they could not detect his fingerprints, said Dr Tan. This is accordingly to the provided link.. I had no idea this could happen while on Xeloda altho I was aware it can create severe damage with Neuropathy. Answered by Jesusa Sahr 1 month ago.

The peeling, bleeding skin on the fingers is a possible side effect of this medication. Here are some more ... Side Effects of Capecitabine: Important things to remember about the side effects of Capecitabine: Most people do not experience all of the side effects listed. Side effects are often predictable in terms of their onset and duration. Side effects are almost always reversible and will go away after treatment is complete. There are many options to help minimize or prevent side effects. There is no relationship between the presence or severity of side effects and the effectiveness of the medication. The side effects of Capecitabine and their severity depend on how much of the drug is given. In other words, high doses may produce more severe side effects. The following side effects are common (occurring in greater than 30%) for patients taking Capecitabine: Low red blood cell count (anemia) Nadir: Meaning low point, nadir is the point in time between chemotherapy cycles in which you experience low blood counts. Onset: N/A Nadir: 10-14 days Recovery: N/A Fatigue Diarrhea Hand-foot syndrome (Palmar-plantar erythrodysesthesia or PPE) -skin rash, swelling, redness, pain and/or peeling of the skin on the palms of hands and soles of feet. Usually mild, has started as early as 2 weeks after start of treatment. May require reductions in the dose of the medication. Nausea and vomiting Dermatitis Elevated liver enzymes (increased bilirubin levels) (see liver problems). These side effects are less common side effects (occurring in about 10-29%) of patients receiving Capecitabine: Poor appetite Abdominal pain Low white blood cell count. (This can put you at increased risk for infection). Low platelet count. (This can put you at increased risk for bleeding). Mouth sores Numbness or tingling of hands or feet Swelling of the feet and ankles Fever Constipation Eye irritation (watery eyes, inflammation of the eyelids, redness). Shortness of breath Headache Chest, back, muscle, joint, bone pain (see pain) Dizziness Insomnia (see sleep disturbances) Dehydration Cough Blood clots. (Blood clots rarely can lead to pulmonary embolus or stroke - potentially life-threatening conditions). Excessive sleepiness, confusion, very rare seizures (see central neurotoxicity). Loss of balance Nail changes, darkening of the skin (see skin reactions) Taste changes Not all side effects are listed above. Some that are rare (occurring in less than 10% of patients) are not listed here. However, you should always inform your health care provider if you experience any unusual symptoms. Answered by Roscoe Billey 1 month ago.


Is Capecite(Capecitabine Tablets 500 mg) a good drug to cure colorectal cancer? Dukes Stage C?
I do trust my mom's doctor....just looking out for her best...still cant believe she's got cancer! Asked by Elmo Klever 1 month ago.

If you do not trust her doctor get another one. We have no information here to second guess. Answered by Shemeka Rigby 1 month ago.

my dad have also coloractal cancer and just had clostomy surgery... Can people back to the normal life after surgery? Answered by Lilli Hipol 1 month ago.


Did you hear about the cancer patient from Singapore, who had no fingerprints at all?
This source reveals that having no fingerprints is a very rare disorder, and that there are only a few known causes - at birth: due to a genetic defects, and later in life: due to cancer drug medications.http://www.handresearch.com/news/cancer-patient-no-fingerprints-hand-foot-syndrome.htmDo you know any... Asked by Delma Asa 1 month ago.

Capecitabine, also known as xeloda, is commonly prescribed for head and neck cancers, breast, stomach as well as colorectal cancers to kill the cancer cells. According to the cancer centre, 40 per cent of the patients may develop hand-foot syndrome, with half of them getting more serious side effects such as chronic inflammation of the palms or soles of the feet, leading to peeling, bleeding and blisters. 'This can give rise to eradication of fingerprints with time. 62-year-old Indonesian patient, known only as Mr S to protect his identity, had received chemotherapy for head and neck cancer. Subsequently, he was kept on a low dose of capecitabine to prevent the cancer's recurrence. He developed mild hand-foot syndrome and was not aware that his fingerprints were gone. He had been taking the medicine for more than three years and was on his way to the United States to visit relatives in December last year when he was stopped at the US Customs because they could not detect his fingerprints, said Dr Tan. This is accordingly to the provided link.. I had no idea this could happen while on Xeloda altho I was aware it can create severe damage with Neuropathy. Answered by Jenise Mushett 1 month ago.


How long Xeloda stays in the body after 6 months taking 7 pills daily?
Asked by Teresita Ronald 1 month ago.

Xeloda (capecitabine) is metabolized and excreted before the day is over that you took it. Elimination half-life is < 1 hour, meaning within ~4 hours virtually all of it is gone. Now, the effects of Xeloda can last for weeks sometimes, long after the last molecule of the drug has gone. Think about getting a sunburn... long after you have left the sun, the effects (sunburn, pain) persist long after you have ceased sun worshipping. God bless, best wishes Answered by Yevette Salmen 1 month ago.

I'm not sure, but I was taking 8 pills a day for 6 months until a couple of weeks ago, and I'm still experiencing one of the side effects - dry skin, soreness on hands and feet. I have asked my nurse about side effects, and she said it takes some time for your body to go back to normal. Answered by Broderick Gallamore 1 month ago.


What can anyone tell me about Xeloda?
I've been fighting liver cancer for almost 3 years now. I had colon-rectal cancer, but that was taken care of through surgery. Just had a 2 year check up and I'm still clean. But, now we're trying Xeloda for my liver. What can I expect, and what side efeects? Asked by Merry Grigoreas 1 month ago.

Xeloda, or capecitabine, is an oral form of the chemotherapy known as 5-fluorouracil (5FU). It is a nucleoside analog and works in many types of cancers, but most commonly in gastrointestinal cancers such as colorectal carcinomas. The main sides effects include lowering of blood counts and rash known as "hand-foot syndrome", but it has the potential for many other side effects seen in other chemotherapies: nausea, diarrhea, fatigue, etc. Answered by Afton Marentes 1 month ago.

I can't answer your question, but I can pray for you. And I shall. I wish you well. Answered by Tari Lakatos 1 month ago.


Can a patient with colon cancer recieve chemotherapy twice a day?
Also are there cases where patients would have to practically live in the hospital to have chemo done? What are common side effects of chemotherapy? Asked by Sandra Sumatzkuku 1 month ago.

Yes, a drug called Xeloda (Capecitabine) used in colon cancer is used twice daily. In addition other medications will also be there as combination chemotherapy is usually prescribed. Yes in alternative therapies as FOLFOX, FOLFIRI etc, admission to hospital is required, as they are continuos therapies. Side effect of therapy depends on the drugs used. Answered by Jacquline Vallow 1 month ago.

The frequency of chemotherapy is dependent on the severity of the cancer. So, if the doctor deems it needed to have two chemo therapies done during the day, then yes, it is possible. Patients often opt to stay at the hospital while having chemotherapy so when any complications occur, medical care is easily given. Also, their condition is easily monitored when in the hospital. Common side effects of chemotherapy include weakness, nausea, headache, loss of appetite, etc. Answered by Lajuana Defrain 1 month ago.

I dont know a whole lot about colon cancer, it would depend on the specific type of cancer and the treatment protocol. However, yes, there are situations like that. My cancer is leukemia, and I was admitted for all of my treatments, for a min of a week and received chemo on a continuous drip for the treatment for 5 days. There are a couple of times that I was admitted for 4 weeks, and once that I was admitted for 6 weeks. That is common for leukemia though. One of my hospital mates had been admitted for 4 months. Talk to the doctor about the specific treatment protocol and the most common side effects associated with the specific meds. If you dont know, cancer and chemo are both just umbrella terms. There are over 200 different types of cancer, so when you say colon cancer, that doesnt tell us a lot, there are many different types of cancer that could start in the colon, and when you say chemo, there are thousands of meds that can fall under that category. Answered by Veta Njoku 1 month ago.


Chemo side effect?
I'm a 21 yr old female and was on Xeloda and oxaliplatin for colon cancer for 6 months until a couple of weeks ago. The skin on my hands and feet went really dark and dry and cracked. The skin on my hands is now peeling off, showing lighter coloured skin underneath. Is that just dry skin peeling off that... Asked by Paul Kluck 1 month ago.

I'm a 21 yr old female and was on Xeloda and oxaliplatin for colon cancer for 6 months until a couple of weeks ago. The skin on my hands and feet went really dark and dry and cracked. The skin on my hands is now peeling off, showing lighter coloured skin underneath. Is that just dry skin peeling off that shouldn't happen, or is it the horrible dark skin coming off and it going back to normal? It's not very sore, just when I bend my fingers, etc. Thanks Answered by Brent Stitzer 1 month ago.

This is a common skin toxicity from capecitabine (Xeloda). Let your doctor know about it as he/she may want to adjust dose. The skin can get discolored and slough off just like after a sunburn; the new pink healthy skin underneath will eventually toughen like normal skin. If your dose remains the same you can generally expect this to recur. God bless, best wishes Answered by Luanne Wineinger 1 month ago.

Goldie, this is a good thing! There is a green tea skin cream (sold at vitiman & health food stores) that you can use on your new skin. I'm so glad you are getting better. I take chemo every single day. You hang in there and take good care! Answered by Von Tanaka 1 month ago.

long term outcomes of chemo and radiation can contain better danger of coming up new cancers interior the destiny. yet another issue-loose one is the better danger of infertility. This better danger should be balanced against the scientific care of the present maximum cancers. without treating the present maximum cancers you do not have a destiny to stand better danger in! Answered by Brittanie Tessner 1 month ago.

I had my skin peel off too, it all comes back in time. Answered by Franklyn Schmertz 1 month ago.


With Pancreatic Cancer using Gemzar as the chemo. What chemo drug is used with radiation?
I know that Gemzar will not be used, what is the drug of choice with chemo and radiation for pancreatic cancer Asked by Kaleigh Horger 1 month ago.

5FU (fluorouracil), either IV or oral (as Xeloda or capecitabine) can be used concurrently with radiation. Gemcitabine (Gemzar) has been used as well in various doses, though toxicities can be considerably more difficult to predict, as that drug is a more potent radiosensitizing agent. It is generally done on a clinical trial. Good luck, best wishes, God bless Answered by Thaddeus Szopinski 1 month ago.


How long does chemo go for someone with leukemia?
How many times a week and how long would each session last? Asked by Onie Froedge 1 month ago.

Chemo is drugs and IV chemo, so that could be daily or 3 times a week, for 3 months or 6 months, in cycles as indicated in last paragraph. Usually the chemical agent prevents cell mitosis, or kills ALL cells, so there must be periods of rest and recovery from it. Most chemotherapy is delivered intravenously, although a number of agents can be administered orally (e.g., melphalan, busulfan, capecitabine). In some cases, isolated limb perfusion (often used in melanoma), or isolated infusion of chemotherapy into the liver or the lung have been used. The main purpose of these approaches is to deliver a very high dose of chemotherapy to tumour sites without causing overwhelming systemic damage. Depending on the patient, the cancer, the stage of cancer, the type of chemotherapy, and the dosage, intravenous chemotherapy may be given on either an inpatient or an outpatient basis. For continuous, frequent or prolonged intravenous chemotherapy administration, various systems may be surgically inserted into the vasculature to maintain access. Commonly used systems are the Hickman line, the Port-a-Cath or the PICC line. These have a lower infection risk, are much less prone to phlebitis or extravasation, and abolish the need for repeated insertion of peripheral cannulae. Harmful and lethal toxicity from chemotherapy limits the dosage of chemotherapy that can be given. Some tumors can be destroyed by sufficiently high doses of chemotheraputic agents. However, these high doses cannot be given because they would be fatal to the patient. Amount is based on body surface area of the patient. You may receive chemotherapy in cycles. A cycle is a period of chemotherapy treatment followed by a period of rest. For instance, you might receive 1 week of chemotherapy followed by 3 weeks of rest. These 4 weeks make up one cycle. The rest period gives your body a chance to build new healthy cells. Answered by Keturah Hamway 1 month ago.

I can only say what mine was when I had APML (Acute Promyelocytic Leukemia - not very common). I had IV chemo for 8days each month for 4 months then oral chemo 1 type every day the other once a week for 2 years. Each IV dose of chemo took about 2hrs sometimes more sometimes less. Every person's treatment is different and it varies greatly through different types of leukemia, the best way to know is by talk to your oncologist if you are receiving treatment. If you are receiving treatment I hope all goes well for you, God bless Answered by Cinda Cumens 1 month ago.

This Site Might Help You. RE: How long does chemo go for someone with leukemia? How many times a week and how long would each session last? Answered by Sherrell Foxwell 1 month ago.

How Long Does Chemo Last Answered by Fonda Tietz 1 month ago.

How Long Does Chemo Take Answered by Brandie Stpierrie 1 month ago.

Only God can say?I had level 2 cancer and was told only 40& live after a year or so.Could not remove it.Chemo 12mo.Radiation 32 days.I am still here almost 5 years and cancer tests show neg. Answered by Marielle Wison 1 month ago.


Any advice on what you can take or eat to stop xeloda from making you feel sick?
hi my mum has had stage 4 colon cancer. after her op she was offered chemo which she is having and also taking xeloda (capecitabine) tablets for 14 days 11 of these day she constantly feels sick. Asked by Deidre Weckenborg 1 month ago.

Hello I took xeloda tablets for 2 out of 3 weeks for 6 months. I often had a problem with swallowing it, and that is what would make me feel sick. If I drank it with water, I would gag and feel horrible. So I tried swallowing it with milk, tea and fruit juices to help get rid of the taste when swallowing, and that really helped. Fatty foods would also make me feel nauseous so I avoided them. As English as it does sound, a cup of tea would really help me with it. I was also on oxaliplatin, and that made me feel worse than the xeloda. What else is she on, or is it just the xeloda? Feel free to message me for any other advice I may be able to give you. Answered by Frankie Battie 1 month ago.

Pre-medication with a nausea medication, such as prochlorperazine (compazine) or ondansetron (zofran) might help. Other options: metoclopramide (reglan); patient today reported eating honeydew melon helped (I looked it up and sure enough there are folk remedy reports about these melons for nausea- interesting); others say buttermilk helps; also could try an alternate schedule of capecitabine, taking it a week on, then week off- might be easier. Talk with her doctor about all of this please as there are many options to make it more tolerable. Blessings Answered by Eleonor Wieser 1 month ago.

I'm sorry to hear about your mum's illness..peppermint tea is very soothing to the stomach. I also have found that coke with lots of ice and a bit of water added helps to soothe as well. Peppermint gum is another idea if she doesn't want to drink anything. Web m.d has a lot of helpful tips for illnesses and meds. Good luck to you both. I hope she feels better soon. Answered by Celena Karpowich 1 month ago.


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