ASPIRIN Ressources

Application Information

This drug has been submitted to the FDA under the reference 203697/001.

Names and composition

"ASPIRIN" is the commercial name of a drug composed of ASPIRIN.
It belongs to the class Antiplatelets and is used in Thromboembolic disorders (Cardiovascular System)

Answered questions

I found out genace is mainly aspirin. What can 15 pills do? No I'm not taking them -.- , my friend did and I wanna know what's gonna happen. Serious answers please. Asked by Erica Wendelin 6 months ago.

Lol, you can't get high of aspirin alone you fool. Answered by Bruno Helsel 6 months ago.

Don't do drugs Answered by Edmundo Linzan 6 months ago.

My puppy accidentally ate aspirin?
My puppy accidentally ate one aspirin. He weighs about 10 pounds. Is he going to be ok? Asked by Leann Critchfield 6 months ago.

Just one probably won't hurt him. If he's really sensitive it may upset the lining of his stomach. Calcium buffers this effect (that's why some aspirins are buffered). A little bit of cheese may help. Maybe like 1/4 of a slice, but no more. Answered by Ligia Wedman 6 months ago.

It should be fine my dog was prescribed buffered aspirin for arthritis, his stomach might get a bit upset if he didn't have any food. feed him something special so the aspirin isn't the only thing in his stomach. Answered by Marisha Stiger 6 months ago.

He will be fine. Aspirin (buffered for dogs) is prescribed for dogs with joint pain. One aspirin will be ok but make sure you watch what he eats and where you keep your medicines. Answered by Mickie Starry 6 months ago.

I'm sure he is fine. You might want to call your vet first though. Answered by Monique Lomg 6 months ago.

he will probably start vomiting. Answered by Jonna Duxbury 6 months ago.

I want know about the history of aspirin?
Asked by Candy Mcnertney 6 months ago.

ASPIRIN - Aspirin is one of the safest and least expensive pain relievers on the marketplace. While other pain relievers were discovered and manufactured before aspirin, they only gained acceptance as over-the-counter drugs in Europe and the United States after aspirin's success at the turn of the twentieth century. HISTORY OF ASPIRIN- The compound from which the active ingredient in aspirin was first derived, salicylic acid, was found in the bark of a willow tree in 1763 by Reverend Edmund Stone of Chipping-Norton, England. (The bark from the willow tree—Salix Alba—contains high levels of salicin, the glycoside of salicylic acid.) Earlier accounts indicate that Hippocrates of ancient Greece used willow leaves for the same purpose—to reduce fever and relieve the aches of a variety of illnesses. During the 1800s, various scientists extracted salicylic acid from willow bark and produced the compound synthetically. Then, in 1853, French chemist Charles F. Gerhardt synthesized a primitive form of aspirin, a derivative of salicylic acid. In 1897 Felix Hoffmann, a German chemist working at the Bayer division of I.G. Farber, discovered a better method for synthesizing the drug. Though sometimes Hoffmann is improperly given credit for the discovery of aspirin, he did understand that aspirin was an effective pain reliever that did not have the side effects of salicylic acid (it burned throats and upset stomachs). Bayer marketed aspirin beginning in 1899 and dominated the production of pain relievers until after World War I, when Sterling Drug bought German-owned Bayer's New York operations. Today, "Aspirin" is a registered trademark of Bayer in many countries around the world, but in the United States and the United Kingdom aspirin is simply the common name for acetylsalicylic acid. The manufacture of aspirin has paralleled advancements in pharmaceutical manufacturing as a whole, with significant mechanization occurring during the early twentieth century. Now, the manufacture of aspirin is highly automated and, in certain pharmaceutical companies, completely computerized. While the aspirin production process varies between pharmaceutical companies, dosage forms and amounts, the process is not as complex as the process for many other drugs. In particular, the production of hard aspirin tablets requires only four ingredients: the active ingredient (acetylsalicylic acid), corn starch, water, and a lubricant... Answered by Nelly Gazzola 6 months ago.

When Was The Aspirin Invented Answered by Eric Jervis 6 months ago.

The active ingredient was first mentioned as a pain killer made from willow bark in the fifth century BC. The buffered form created Aspirin in 1897. The rest of the story is on Wikipedia. Follow the link. Answered by Marx Placha 6 months ago.

Aspirin (acetylsalicylic acid) is derived from Willow bark. The Native American people made a tea of the bark,and used it to treat fevers and arthritis. It became known to American colonists,and then to Europeans. In the late 1890's ,it was extracted and refined by a German chemist( H. Dreser ) into what we now know as the modern form of this anti-inflammatory medication. Answered by Brendan Zingarelli 6 months ago.

Felix Hofman, a 29 year old chemist who worked for the German company Bayer invented aspirin in April 1879. By 1940 it was the best selling painkiller in the world. Answered by Newton Mateo 6 months ago.

(L) Aspirin or acetylsalicylic acid, is a derivative of salicylic acid that is a mild, nonnarcotic analgesic useful in the relief of headache and muscle and joint aches. The drug works by inhibiting the production of prostaglandins, body chemicals that are necessary for blood clotting and which also sensitize nerve endings to pain. The father of modern medicine was Hippocrates, who lived sometime between 460 B.C and 377 B.C. Hippocrates was left historical records of pain relief treatments, including the use of powder made from the bark and leaves of the willow tree to help heal headaches, pains and fevers. By 1829, scientists discovered that it was the compound called salicin in willow plants which gave you the pain relief. According to "From A Miracle Drug" written by Sophie Jourdier for the Royal Society of Chemistry: "It was not long before the active ingredient in willow bark was isolated; in 1828, Johann Buchner, professor of pharmacy at the University of Munich, isolated a tiny amount of bitter tasting yellow, needle-like crystals, which he called salicin. Two Italians, Brugnatelli and Fontana, had in fact already obtained salicin in 1826, but in a highly impure form. By 1829, [French chemist] Henri Leroux had improved the extraction procedure to obtain about 30g from 1.5kg of bark. In 1838, Raffaele Piria [an Italian chemist] then working at the Sorbonne in Paris, split salicin into a sugar and an aromatic component (salicylaldehyde) and converted the latter, by hydrolysis and oxidation, to an acid of crystallised colourless needles, which he named salicylic acid." Henri Leroux had extracted salicin, in crystalline form for the first time, and Raffaele Piria succeeded in obtaining the salicylic acid in its pure state. The problem was that salicylic acid was tough on stomachs and a means of 'buffering' the compound was searched for. The first person to do so was a French chemist named Charles Frederic Gerhardt. In 1853, Gerhardt neutralized salicylic acid by buffering it with sodium (sodium salicylate) and acetyl chloride, creating acetylsalicylic acid. Gerhardt's product worked but he had no desire to market it and abandoned his discovery. In 1899, a German chemist named Felix Hoffmann, who worked for a German company called Bayer, rediscovered Gerhardt's formula. Felix Hoffmann made some of the formula and gave it to his father who was suffering from the pain of arthritis. With good results, Felix Hoffmann then convinced Bayer to market the new wonder drug. Aspirin was patented on March 6, 1889. The folks at Bayer came up with the name Aspirin, it comes from the 'A" in acetyl chloride, the "spir" in spiraea ulmaria (the plant they derived the salicylic acid from) and the 'in' was a then familiar name ending for medicines. Aspirin was first sold as a powder. In 1915, the first Aspirin tablets were made. Interestingly, Aspirin ® and Heroin ® were once trademarks belonging to Bayer. After Germany lost World War I, Bayer was forced to give up both trademarks as part of the Treaty of Versailles in 1919. Answered by Denese Delarosa 6 months ago.

...go to Google... type PDR and look it up.. Acida-salic-silic-acid. Great stuff) Answered by Wanda Thero 6 months ago.

What hapensif a dog eats aspirin?
Asked by Ashley Horning 6 months ago.

Aspirin (regular or buffered) is not toxic to dogs like ibuprofen and acetaminophen are. Aspirin can be given to dogs in the correct dose. (It is usual for a vet to reccommend buffered aspirin, not because regular aspirin is toxic, but because it is gentler on the digestive system.) If your dog has eaten a couple of aspirin tablets then he/she will probably just get diarrhea (aspirin can be tough on the digestive tract) If on the other hand your dog has eaten a whole bottle of aspirin it is time to take him to the vet. Even though aspirin isn't toxic in lower quantities, it can cause a myriad of problems in larger dosages. If your dog ate a large amount of aspirin just a little while ago, you could try giving him/her 1 tsp of hydrogen peroxide per ten pounds. This will make your dog vomit up the pills. You should still take your dog to the vet because they will probably want to administer activated charcoal to stop the absorption of any aspirin that is left in the system after the vomiting. Answered by Shirleen Milcher 6 months ago.

Dog Ate Aspirin Answered by Taylor Garriss 6 months ago.

I would induce vomiting if it was regular aspirin because that is is poisonous, buffered aspirin is okay in small amounts depending on the weight of the dog and can be used as a pain killer as suggested by a vet. Three percent hydrogen peroxide is quite effective in making dogs and cats vomit. You must be sure to use three percent peroxide and not hair coloring strength peroxide.Despite the label indicating that hydrogen peroxide is toxic, it is safe to give to dogs for this purpose. It is considered toxic since it induces vomiting and therefore does not stay in the body. The appropriate dose of hydrogen peroxide is one teaspoon per 10 pounds of body weight. If you have an oral syringe, one teaspoon equals 5 cc or 5 ml. Once given, walk your dog around or gently shake the stomach area to mix the peroxide with the stomach contents. Vomiting should occur within 15 to 20 minutes. If no vomiting occurs, you can safely repeat the three percent hydrogen peroxide once. If it is still not effective, your dog may need to be seen by a veterinarian for stronger vomiting medication. Once the hydrogen peroxide is given, it is important to watch your pet so that he does not re-ingest the substance. If there is concern about toxicity, collect and take a sample of the vomitus to your veterinarian. Answered by Florentina Moldenhauer 6 months ago.

This Site Might Help You. RE: what hapensif a dog eats aspirin? Answered by Carlotta Enochs 6 months ago.

Aspirin can be used to relieve pain in a dog but the dosage might be harmful to your dog depending on their weight and age. Aspirin should not be given to puppies. 40mgs per 8lbs is pretty standard. An overdose of over 30mgs should be monitored by a vet. Answered by Jolynn Hankerson 6 months ago.

well any dog that eats human medication may be ill for a bit. Take them to the vet. Answered by Pearlie Bobbit 6 months ago.

They could get stomach ulcer and kidney problems Answered by Zora Garms 6 months ago.

How much? That can be fatal. Answered by Brett Fikes 6 months ago.

The compound element equation for aspirin?
Asked by Letty Dobek 6 months ago.

Aspirin is the most widely used over-the-counter drug in the world. The average tablet contains about 325 milligrams of acetylsalicylic acid with an inert binding material such as starch. Aspirin is used to relieve pain, reduce inflammation, and lower fever. Aspirin originally was derived by boiling the bark of the white willow tree. Although the salicin in willow bark has analgesic properties, purified salicylic acid was bitter and irritating when taken orally. Salicylic acid was neutralized with sodium to produce sodium salicylate, which was better-tasting but still irritated the stomach. Salicylic acid could be modified to produce phenylsalicylate, which was better tasting and less irritating, but released the toxic substance phenol when metabolized. Felix Hoffman and Arthur Eichengrün first synthesized the active ingredient in aspirin, acetylsalicylic acid, in 1893. In this laboratory exercise, you can prepare aspirin (acetylsalicylic acid) from salicylic acid and acetic anhydride using the following reaction: salicylic acid (C7H6O3) + acetic anhydride (C4H6O3) --> acetylsalicylic acid (C9H8O4) + acetic acid (C2H4O2) Answered by Lennie Makino 6 months ago.

If you want to know what it looks like, draw a benzene ring, stick COOH on to one of the carbon atoms and OCOCH3 on an adjacent one (called the "ortho" position) and there you have it. Answered by Eugenia Humphrey 6 months ago.

There are two of them (the numbers are subscripts) C6H4(OCOCH3)COOH C9H8O4 Answered by Dexter Gehrlein 6 months ago.

C9H8O4 numbers are subscripts Answered by Kathey Niznik 6 months ago.

C6H4(OCOCH3)CO2H Answered by Cody Sainte 6 months ago.

From wich product we get aspirin?
Asked by Rhonda Pucciarelli 6 months ago.

Aspirin, trade name for acetylsalicylic acid, the most widely used drug for treating fever, pain, and inflammation. Aspirin is a synthetic chemical compound that works by interfering with the body’s production of hormonelike substances called prostaglandins. Often called a wonder drug, it is now thought to have possible preventative effects against heart disease, stroke, forms of cancer, and other diseases and condition Aspirin derives from salicylic acid, a compound found in the bark of the willow and in parts of other plants. The effects of plants that contain salicylic acid were known since ancient times in many cultures, ranging from ancient Egyptians and ancient Greeks to the Chinese and Native Americans. The 4th century BC Greek doctor Hippocrates, called the father of medicine, prescribed tea extracted from the bark of the willow tree for fever and pain. Salicylic acid was isolated for use as a medicine in the 19th century. However, salicylic acid is bitter and irritates the stomach. Attempts to derive a compound without such side-effects were largely unsuccessful. In 1897 the German chemist Felix Hoffman synthesized the acetyl derivative of salicylic acid in response to the urging of his father, who took salicylic acid for rheumatism. The compound was marketed under the trade name “Aspirin” by the German chemical company Bayer, and became a worldwide success as a pain reliever. II Uses Answered by Vera Yampolsky 6 months ago.

Aspirin is the common name for acetylsalicylic acid which is made from salicylic acid and acetic anhydride. Salicilyc acid is extracted from the bark of willow tree and its name comes from salix that is its name in latin. The effects of salicylic acid are very similar to those of aspirin however they are less potent. This because the acetyl group added make the molecule penetrate the blood-brain barrier easly. A similar thing happens with morphine and heroin (DIACETYLmorphine). Answered by Teresita Wytch 6 months ago.

Acetylsalicylic acid. C9H8O4 180.160 g/mol A French chemist, Charles Frederic Gerhardt, was the first to prepare acetylsalicylic acid (named aspirin in 1899) in 1853. In the course of his work on the synthesis and properties of various acid anhydrides, he mixed acetyl chloride with a sodium salt of salicylic acid Answered by Barabara Boies 6 months ago.

It's all artificial now but was origonally compound was isolated from witch hazel which was used as a pain killer in the middle ages and propoply eons before, distilled witch hazel can still be brought and used to treat bruses and spranes (Externally) and other things. Answered by Casie Chernow 6 months ago.

Is baby aspirin gd for dogs?
Asked by Jacob Rodda 6 months ago.

Giving Your Dog Aspirin by Ron Kurtus If your dog has chronic pain or inflammation, common aspirin can often be used to give your pet some relief. Since aspirin can cause stomach problems, care should be used, and it should always be given with food. The safe amount of aspirin to give depends on your dog's weight. It is always wise to check with your vet before administering aspirin or any other medication. Questions you may have include: What is aspirin used for in dogs? What warnings or problems are there? How much should I give? This lesson will answer those questions. Animal Health Disclaimer Uses for aspirin Dogs are most commonly given aspirin for treatment of arthritis and associated joint pain. There may be other situations where your dog is in pain, where aspirin may give relief. Aspirin has good anti-inflammatory effects that reduce swelling. It can also reduce pain and fever. These effects will help make your dog more comfortable. Note that a dog is not a human. Just because your dog "does not feel good", it is not a reason to give it an aspirin. Usually, aspirin is given as temporary solution to relieve extreme conditions of discomfort. Also note that most vets prescribe Rimadyl as a better pain-killer and anti-inflammatory than aspirin. Use caution You should use caution In administering any medication to a pet. Giving too large of a dose of aspirin may be toxic to your dog. Sometimes the medicine may not be tolerated or it can cause an upset stomach. If often given without food, aspirin can cause ulcers in the stomach. Can be toxic It can be toxic if given in high doses of about 30 mg (milligram) per pound of the dog. This means that even a baby aspirin could be poisonous for dogs weighing two pounds or less. An adult aspirin, which is 320 mg, would be toxic for a 10-pound dog. Use extreme caution when giving aspirin to a very small breed dog. It is also better to give less than more. To be sure that you are using the aspirin for the right reason and at the right dose, you should consult your veterinarian first. Not for young dogs or cats Aspirin is poorly tolerated by young dogs, since they lack the enzymes necessary to process the aspirin. The same is true for most cats. Do not give aspirin to your puppy or to your cat. NOTE: There is more information at the source below. Answered by Karl Antis 6 months ago.

My vet told us to give it to our pitbull at night after he has his monthly treatments. He's fine so it's probably not bad Answered by Ricky Ellerd 6 months ago.

What ever happened to aspirin?
What happened to aspirin the painkiller supplement? It used to be so mainstream in the 90's. But what happened to it? Asked by Alaine Kieser 6 months ago.

Why do you think Aspirin is no longer used? Aspirin is certainly still a commonly used medication. It is NOT the same as a supplement which is unregulated and does not need to be proven to be effective. Aspirin, on the other hand, is FDA approved and many dozens of studies have found it to be an effective drug. Actually over the last ten years there has been a huge surge of Aspirin use largely due to 1) the evidence it can help with cardiovascular problems like helping to prevent heart attack, thrombotic stroke and for acute coronary syndrome and 2) the increase in number of people with chronic pain. Currently chronic pain is an epidemic problem in The US and many people use Aspirin since it is typically very effective and cheap. However the overuse of drugs like Aspirin leads to hundreds of thousands of hospitalizations. Actually it was during the early 90's that Aspirin lost much of its market share. In 1995 (+/- a year) sales started to go up significantly. Having said that it is true that Aspirin is not typically the preferred first-line OTC pain medication although since it has cardiovascular benefits, it has a much longer and well established safety record than other OTC medications, and actually no OCT medication has been shown to be more effective than Aspirin it is still a popular choice for many. A few studies have actually shown Tylenol #3 (codeine/APAP) to be no more effective than Aspirin in some instances. I would certainly say if a person is in pain and needs the strongest OTC medication (assuming they can safely take Aspirin) I think Aspirin is a great choice for SHORT TERM use as an analgesic or antipyretic. Several common prescription medications combine one or more drugs with Aspirin like Percodan (oxycodone/aspirin), Fiorinal (butalbital/aspirin/caffeine), Fiorinal with Codeine (butalbital/aspirin/caffeine/codeine), Soma Compound (carisoprodol/aspirin), Soma Compound with Codeine (carisoprodol/aspirin/codeine), and others. So Aspirin has not really gone anywhere, it is not used exactly as it once was but overall most years show an increase in Aspirin use. It is also worth mentioning that within the last year or two there have been a lot more concerns about the risks from using any type of NSAID, the class of drugs Aspirin is in. In addition children can't take Aspirin, people with asthma and certain other problems should not typically take Aspirin. Answered by Marjory Veeser 6 months ago.

Doesn't make enough profit for the drug companies, as the patent expired years ago. Besides better pain relief has replaced it. Answered by Cecil Larrosa 6 months ago.

Why does aspirin have a yield of 75%?
Can you give me reasons as to why aspirin has a yield of 75%? Thanks Asked by Diamond Karlsson 6 months ago.

To chemically synthesise aspirin in a lab, you combine salicylic acid (C7H6O3) and acetic anhydride (C4H6O3). Aspirin is C9H8O4, and so combining salicylic acid and acetic anhydride to make aspirin leaves an excess of C2H4O2 (acetic acid.) To put it simply, when combining C7H6O3 and C4H6O3, you get a total of C11, H12, and O6. However, aspirin only has C9, H8, and O4. So... C11H12O6 - C9H8O4 = C2H4O2. The acetic acid is your extra 25% that you lose out of the total mass, but you need to find the molar masses of each atom to ascertain that. Carbon has a molar mass of 12 g/mol Hydrogen has a molar mass of 1 g/mol Oxygen has a molar mass of 16 g/mol Knowing what the molar mass of each individual atom is, you can now find the total molar mass of the two compounds used to make the aspirin, as well as the total molar mass of the aspirin and the byproduct acetic acid. You do this by multiplying the molar mass of a single atom, either carbon, hydrogen, or oxygen, by the number of those atoms. The equation goes as follows: Solving for C11H12O6 (our total mass of the two compounds used to make the aspirin): (11*12)+(12*1)+(6*16), simplified to... 132+12+96 = 240 So our total mass used is 240 g/mol. Now, we can either solve for the mass of the aspirin, or for the mass of the resultant acetic acid, to find why we get a yield of only 75%. I'll solve for both, just so that you can see everything. Solving for C9H8O4 (aspirin): (9*12)+(8*1)+(4*16), simplified to... 108+8+64 = 180 So our total yield, in molar mass, of aspirin is 180 g/mol. If we take our result for the amount of aspirin yielded and divide it by the total mass used to create it, we get the equation: 180 / 240 = 0.75 As anyone well versed in even the most basic of mathematics knows, 0.75 is the same as 75% when the result of such an equation. So, here, we clearly see that aspirin has only 75% of the mass from the two compounds used to make it. But lets solve for the acetic acid, anyway, even though the result is obvious. Solving for acetic acid (C2H4O2): (2*12)+(4*1)+(2*16), simplified to... 24+4+32 = 60 So our total yield of acetic acid is 60 g/mol. Plug it in, 60/240 = 0.25, or 25%. Aspirin's chemical composition doesn't change, here, and neither do the compositions of the two chemicals used in synthesising it. So, because there is an imbalance in the combined number of molecules in salicylic acid and acetic anhydride, and the aspirin that they combine to make, the extra molecules become acetic acid. Only 75% of the mass of the molecules used actually becomes aspirin. If this didn't answer your question, I'm very sorry, but this is the answer that I could find that seemed to best fit the question. Also, if you notice any inconsistencies when looking up molar masses of carbon, hydrogen, and oxygen, it could be because specific isotopes were used, and not necessarily the 'basic' version. For instance, carbon-12 was used, as opposed to just plain carbon that has a molar mass of only 6 g/mol. Also, in my first source, they mentioned, 'Assume 100% yield,' which I believe meant to assume that no atoms get lost or added during the chemical reaction, and that all of the atoms from the two chemical compounds are maintained when making the aspirin, and the byproduct of acetic acid. If not, then I'm a bit puzzled, and would just disregard that. Answered by Viviana Hamza 6 months ago.


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Alliance Pharmaceuticals Ltd

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