Is nefiracetam a more efficacious nootropic than the eugeroics, such as modafinil, armodafinil, or adrafinil?
Asked by Maribeth Lambrakis 6 months ago.
Yes, nefiracetam is more effective than the ampakines (e.g., adrafinil, armodafinil, modafinil) for cognitive and memory enhancement, and all are more effective than such stimulants as caffeine and theophylline. The word nootropic was coined upon discovery of the effects of piracetam, developed in the 1960s. Although piracetam is the most commonly taken nootropic, there are many relatives in the family which have different potencies and side effects. Other commom racetams include pramiracetam, oxiracetam, and aniracetam. There is no generally accepted mechanism for racetams. They generally show no affinity for the most important receptors, although modulation of most important central neurotransmitters have been reported, including acetylcholine and glutamate. Although aniracetam and nebracetam show affinity for muscarinic receptors, only nefiracetam shows it at the nanomolar range. Racetams have been called "pharmacologically safe" drugs. Nootropics, also referred to as smart drugs, memory enhancers, and cognitive enhancers, are drugs, nutraceuticals, brain food and functional foods that are purported to improve human cognitive abilities. Eugeroics ("wakefulness enhancers") are a key category of stimulants. Although their primary biochemical mechanisms are unproven, their efficacy is well documented. Of the three major eugeroics, armodafinil may ultimately prove to be the most efficacious, since its stereochemistry is more bioactive than the racemic modafinil. Modafinil, in turn, is more efficacious than adrafinil, which is more slowly metabolized. Modafinil (Provigil/Alertec/Modavigil) is a stimulant drug manufactured by Cephalon, and is approved by the FDA for the treatment of narcolepsy, shift work sleep disorder, and excessive daytime sleepiness associated with obstructive sleep apnea. Modafinil, like other stimulants, increases the release of monoamines, but also elevates hypothalamic histamine levels, leading some researchers to consider Modafinil a "wakefulness promoting agent" rather than a classic amphetamine-like stimulant (as evidenced by the difference in c-fos distribution caused by modafinil as compared to amphetamine). Although modafinil is thought to be effective in the treatment of Attention-Deficit Hyperactivity Disorder (ADHD), in 2006 it was specifically rejected by the FDA for use by children for that purpose after Cephalon was rebuffed in its effort to introduce modafinil as a children's drug under the trade name, Sparlon. Cephalon's own label for Provigil now discourages its use by children for any purpose. Armodafinil (Nuvigil) is a stimulant-like drug produced by the pharmaceutical company Cephalon Inc., which was approved by the FDA on June 15, 2007. Armodafinil is the active (−)-(R)-enantiomer of the racemic drug modafinil (Provigil). Cephalon plans to conduct clinical trials evaluating the use of Nuvigil as a treatment for serious medical conditions such as bipolar depression, cognition associated with schizophrenia, and excessive sleepiness and fatigue in conditions such as Parkinson's disease and cancer, but it is still in the clinical testing stage. Adrafinil is a mild central nervous system stimulant drug used to relieve excessive sleepiness and inattention in elderly patients. It is also used off-label by individuals wishing to avoid fatigue, such as night workers or others who need to stay awake and alert for long periods of time. Adrafinil is a prodrug; it is primarily metabolized in vivo to modafinil (Provigil), resulting in nearly identical pharmacological effects. Unlike modafinil, however, it takes time for the metabolite to accumulate to active levels in the bloodstream. Effects usually are apparent within 45-60 minutes when taken orally on an empty stomach. Answered by Misty Lungstrom 6 months ago.
Does anyone take, or ever tried, Provigil/Modafinil, Nuvigil/Armodafinil, Modalert, or Waklert?
Does anyone take, or ever tried, Provigil/Modafinil, Nuvigil/Armodafinil, Modalert, or Waklert? If so, how exactly does it affect you? How long does it last? How long does it take to kick in? What dosage do you take daily? Does your body build a tolerance to it?
Asked by Twanda Dellaca 6 months ago.
I have no idea what it is. Answered by Filomena Brigham 6 months ago.
I use it for jet lag when going to Europe. Use Provigil. You feel that you are achy and excessively tired until you increase the dosage. At home, take for a few days, then stop cold to recover. You sleep an amazing amount! Answered by Tonisha Sineath 6 months ago.
During a yearly checkup, my doctor impressively picked up on my sleep disorder (personally, I thought he was nuts; I felt it was just all the crazy stress in my life that made me want to sleep at any chance I got). Well, my sleep study came back severely abnormal. What?? Are you kidding me??? He was right! I was diagnosed with excessive daytime sleepiness/narcolepsy without cataplexy. Since then, I have been on Provigil. I cannot begin to tell you the difference it has made! The response was immediate for me, and I'm so glad I no longer have to sleep my days away! What an interesting field of medicine! I believe what they know about sleep now is just a scratch on the surface on how it impacts our health and well being. Answered by Marleen Lafkas 6 months ago.
Is nuvigil a depressant or stimulant?
Asked by Melinda Mongillo 6 months ago.
Armodafinil (Nuvigil) is a stimulant-like drug produced by the pharmaceutical company Cephalon Inc., which was approved by the FDA on June 15, 2007. Armodafinil is an enantiopure drug consisting of just the active (−)-(R)-enantiomer of the racemic drug modafinil (Provigil). While it acts like a stimulant, it's pharmacology is different. Answered by Roselyn Peniston 6 months ago.