APREPITANT Ressources

Application Information

This drug has been submitted to the FDA under the reference 090999/001.

Names and composition

"APREPITANT" is the commercial name of a drug composed of APREPITANT.
It belongs to the class Neurokinin NK 1 antagonists and is used in Nausea, vomiting (Central Nervous System)

Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
090999/001 APREPITANT APREPITANT CAPSULE/ORAL 40MG
090999/002 APREPITANT APREPITANT CAPSULE/ORAL 80MG
090999/003 APREPITANT APREPITANT CAPSULE/ORAL 125MG

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
090999/001 APREPITANT APREPITANT CAPSULE/ORAL 40MG
090999/002 APREPITANT APREPITANT CAPSULE/ORAL 80MG
207865/001 EMEND APREPITANT FOR SUSPENSION/ORAL 125MG per KIT
090999/003 APREPITANT APREPITANT CAPSULE/ORAL 125MG
021549/001 EMEND APREPITANT CAPSULE/ORAL 80MG
021549/002 EMEND APREPITANT CAPSULE/ORAL 125MG
021549/003 EMEND APREPITANT CAPSULE/ORAL 40MG

Manufacturers

Manufacturer name
Merck Sharp & Dohme Ltd

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Answered questions

Birth control mixed with other medications?
I'm taking Loestrin Fe 1/20 Oral, and wanted to find out what other medications, if taken in combination with this would decrease the effectiveness. I know that antbiotics can decrease effectiveness, but does anyone know of any other drugs that may do the same? I also take Tramadol for back pain. Asked by Hong Martella 2 months ago.

Acitretin, aprepitant, azole antifungals (eg, ketoconazole), barbiturates (eg, phenobarbital), bosentan, carbamazepine, felbamate, griseofulvin, hydantoins (eg, phenytoin), modafinil, nevirapine, penicillins (eg, amoxicillin), protease inhibitors (eg, indinavir), rifamycins (eg, rifampin), St. John's wort, tetracyclines (eg, doxycycline), topiramate, or troglitazone because they may decrease Loestrin 1/20's effectiveness. While on these medicines, you will need an alternative form of birth control (eg, condoms) until your next period after stopping these medicines. Beta-blockers (eg, metoprolol), cyclosporine, theophyllines, or troleandomycin because the risk of their side effects or toxicity may be increased by Loestrin 1/20 Corticosteroids (eg, prednisone) because their side effects, including rounding of the face, weight gain, fluid retention, elevated blood pressure, elevated blood sugar, or skin changes, may be increased by Loestrin 1/20 Oral anticoagulants (eg, warfarin) because their side effects, including risk of bleeding, may be increased by this medicine; however, it is also possible that the effectiveness may also be decreased by Loestrin 1/20 Lamotrigine because its effectiveness may be decreased by Loestrin 1/20; stopping Loestrin 1/20 may lead to severe side effects Answered by Alessandra Cristello 2 months ago.

if you have any prescribed drugs from the hospital they will tell you if they will effect your birth control. if you're unsure when they give you the meds, you should ask, just in case they may forget. if you are taking over the counter drugs, just ask the pharmacist at the drug store if the meds will effect your birth control. Answered by Kortney Heil 2 months ago.

You will need to use a non-hormonal form of birth control. Condoms, an IUD or a diaphragm. You are best to talk with your doctor or family planning specialist. Answered by Nathaniel Marquart 2 months ago.


Is there a pharmacist on line that can answer some therapeutic class questions?
I am doing some Part B versus Part D reseach and need help determining a couple of drugs, for instance, I need to know which Oral antiemetics that have no other indication besides chemotherapy. Asked by Blaine Trejo 2 months ago.

look at the -sterons and aprepitant Answered by Elijah Midcap 2 months ago.


How is the drug Emend for post-op nausea?
My Bariatric doctor recommended it since I always get violently ill whenever I've gone under General Anesthesia....hopefully this time I won't have that problem. Asked by Bethany Taschner 2 months ago.

I've only ever seen Emend used for chemotherapy-related nausea and vomitting. This new use for Emend (aprepitant) with postoperative nausea and vomitting is great, it looks as if it is more effective than the classic ondansetron (aka Zofran) and may be longer-acting. The only consideration that I can think of at this point is the length of your surgery. The research recommends aprepitant be given 3 hours before surgery, but that may need to be adjusted if you are undergoing a surgery longer than an hour, because Emend peaks at hour 4, so you would want to be waking up just as it was peaking. Remember, you don't have to pick just one drug and stick with it. You might be able to combine ondansetron, metoclopramide, and emend. Talk to the anesthetist. Also, when you are waking up after surgery, talk to the recovery room nurses and tell them at the first glimmer of nausea so that they can help you get it under control before you're actually vomitting. This is especially important if your surgery involves your torso or abdomen, because violent, repeated vomitting can negatively impact the surgical site. Finally, be sure to go over all the medications, herbal supplements, vitamins, etc you are already on, because the list of interactions for aprepitant is long-ish. Good luck with your next procedure! Answered by Monique Wendeln 2 months ago.


Does anybody here take the birth control pill Cryselle?
Does it have any interactions with the anti depressant Lexapro? Asked by Thomasine Gullung 2 months ago.

Although Lexapro is not mentioned by name all medicine for mental depression might interact: What drug(s) may interact with ethinyl estradiol; norgestrel? (Cryselle etc). •anastrozole •antibiotics or medicines for infections, especially rifampin, rifabutin, rifapentine, and griseofulvin •aprepitant, a medicine used for chemotherapy-induced nausea and vomiting •barbiturate medicines for producing sleep or treating seizures (convulsions) •bosentan •carbamazepine •caffeine •clofibrate •cyclosporine •dantrolene •doxercalciferol •exemestane •grapefruit juice •hydrocortisone •letrozole •medicines for anxiety or sleeping problems, such as diazepam or temazepam •medicines for mental depression •medicines for diabetes, including troglitazone and pioglitazone •mineral oil •modafinil •mycophenolate •nefazodone •oxcarbazepine •phenytoin •prednisolone •ritonavir or other medicines for the treatment of the HIV virus or AIDS •selegiline •soy isoflavones supplements •St. John's wort •tamoxifen or raloxifene •testolactone •theophylline •topiramate •warfarin Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check before stopping or starting any of your medicines. What side effects may I notice from taking ethinyl estradiol; norgestrel? (Back to top) Severe side effects are relatively rare in women who are healthy and do not smoke while they are taking oral contraceptives. On average, more women have problems due to complications from getting pregnant than have problems with oral contraceptives. Many of the minor side effects may go away as your body adjusts to the medicine. However, the potential for severe side effects does exist and you may want to discuss these with your health care provider. The following symptoms or side effects may be related to blood clots and require immediate medical or emergency help: •chest pain •coughing up blood •dizziness or fainting spells •leg, arm or groin pain •severe or sudden headaches •stomach pain (severe) •sudden shortness of breath •sudden loss of coordination, especially on one side of the body •swelling of the hands, feet or ankles, or rapid weight gain •vision or speech problems •weakness or numbness in the arms or legs, especially on one side of the body Answered by Obdulia Stretz 2 months ago.

why would you want fake birth control pills?? do not say you are trying to trick a guy into getting you pregnant... Answered by Arnette Goodier 2 months ago.


Microgynon and amoxicillin?
I have been taking microgynon for the past 7 years, at the start of my new packet of the pill I had to take the antibiotic amoxicillin, my partner and I had intercourse on the night I started my new packet of pills and he ejaculated inside me, I went to the toliet straight away but could i be pregnant? Asked by Cindi Mckneely 2 months ago.

You definitely need backup birth control while on Amoxicillin. Amoxicillin and other antibiotics definitely affect how the pill works. I have heard MANY stories of women getting pregnant while on the pill because they were on antibiotics. Doctors don't always mention all the possible side effects of a medication, especially if they aren't your usual doctor. You should go see your doctor or at least talk to your pharmacist immediately. Because the "morning after pill", Plan B, is hormonal like birth control pills, I am not 100% sure that it would work while you are taking antibiotics either. Answered by Hope Swickheimer 2 months ago.


What medications interfere with my birth control?
I use Biotin and I take Microgestin Fe 1/20 birth control i was wondering if the biotin affects the birth control of if its fine. I know some medications make it less affective. I also use raspberry ketone...help!? Asked by Thomasine Gough 2 months ago.

Some medications can affect the pill.Ask your doc for advice on your particular medication. Answered by Kristina Wilmes 2 months ago.

Antibiotics will affect them Answered by Janina Dunnavant 2 months ago.


My mom has cancer, what can help with puking?
My mom has stage 3 non-hodgkins lymphoma and has problems with puking. Shes going through chemotherapy and shes having a very hard time. What can I do to help to make her feel better? Thanks a lot. Asked by Horacio Vactor 2 months ago.

The strongest anti emetic in market at present is "aprepitant". It is more effective than ondansetrone(Zofran), tropisetrone or other drugs. In addition to aprepitant , ondansetrone/tropisetrone, other older drugs like metoclopramide also are effective but should be used in higher than normal dosage. Ask your doctor to prescrribe the above ones. In addition at home you can give your mother ginger ale. Make sure that your mother takes lots of water after chemotherapy, that may also help. Answered by Lisa Baginski 2 months ago.

have her ask her doctor about prescribed anti-nausea meds. i was just diagnosed with non-hodgkin's lymphoma this month (i'm only 20) and my doctor gave me some really good pills to take that help with nausea. you don't even have to swallow them - they dissolve in your mouth. i think the pills are called Zofran but i have the generic kind (not that it matters - they both work the same). anyway, good luck to your mom and God bless <3 she's in my prayers Answered by Marybeth Caicedo 2 months ago.

You can go pick up her prescription for anti nausea med that her dr prescribed her. Zofran was the only thing that helped me! Lol aprepitant IS Emend! Answered by Dalene Stinchcomb 2 months ago.


I have had hiccups for 3 days straight~~~ 10 points for help?
i had the flu....when i got a steroid shot i came home and had the hiccups....they come and go but they have kept me up in the middle of the night even continuing for 3 hours one time.....i drink lots of water but it doesn't really work and i have tried most alllllll of the hiccup remedies....please give me an... Asked by Alonso Himber 2 months ago.

i had the flu....when i got a steroid shot i came home and had the hiccups....they come and go but they have kept me up in the middle of the night even continuing for 3 hours one time.....i drink lots of water but it doesn't really work and i have tried most alllllll of the hiccup remedies....please give me an explanation and some HELPPPP! thanks! 10 points to best answer!!!! Answered by Georgianne Soun 2 months ago.

the only element that ever works for me is a spoonful of peanut butter. It ameliorations your respiration types purely precise simply by fact of its stickiness. uncertain if this is interior the abode therapy e book, in spite of the undeniable fact that this is fool-evidence at my abode. Answered by Katie Diga 2 months ago.


Can a woman take birth control pills with diet pills and still have the pill be effective?
I am currently on loestrin24e and was wondering is there any research proving that the pill will not be effective if the person takes the pill also? Asked by Rita Goodfriend 2 months ago.

The birth control pill consists of hormones which essentially make your body think it is pregnant. Your ovaries will then not release an egg each month, meaning that sperm would have nothing to fertilize. Advantages- very effective when taken properly, can lessen PMS symptoms, lighten "period" bleedings Disadvantages- must remember to take a pill every day, at around the same time. some people experience other side effects. After you stop taking the pill, the extra hormones go away and you can become pregnant again. Your period does not go away completely, but it is more correctly called a "withdrawal bleed," since it is not a true period and is just a break in the hormone dose to allow your body to continue to regulate itself. The pill AND a condom is one of the most effective methods of preventing pregnancy! Perfect use of both methods is over 99% effective. Answered by Carlene Ubence 2 months ago.


Could the contraceptive pill be dangerous?
It seems pretty unnatural to suppress ovulation by pumping yourself full of synthetic hormones. Could it have any harmful side effects? Asked by Elana Birrell 2 months ago.

The combined oral contraceptive (COC) pill is generally well tolerated and few women will experience side effects. Some of the side effects that have been reported while taking COC are listed below. * Breakthrough bleeding and spotting - particularly during the first three months of taking it. * Breast tenderness and breast enlargement. * Change in shape of the cornea (front covering of the eye) resulting in discomfort when wearing contact lenses. * Depression (low mood). * Fluid retention. * Headache. * Migraine. * Nausea (feeling sick) or vomiting (being sick). * Reduced libido (interest in sex). * Rise in blood pressure. * Rise in blood sugar. * Stomach upset. * Temporary infertility after stopping the COC pill. * Vaginal thrush. * Weight gain. The combined oral contraceptive (COC) pill may interact with other medicines. Some of the more commonly known interactions are described below. However, this is not a complete list. If you want to check that your medicines are safe to take with the COC pill, you can ask your GP, or pharmacist, or read the patient information leaflets that come with your medicines. The COC pill may interact with broad spectrum antibiotics. These include the following: * amoxicillin, * ampicillin, * azithromycin, * cefadroxil, * cefixime, * cefradine, * cefalexin, * cefpodoxime, * clarithromycin, * co-amoxiclav, * co-fluampicil, * doxycycline, * erythromycin, * metronidazole, * minocycline, * oxytetracycline, * tetracycline, * and tinidazole. Broad spectrum antibiotics may reduce the effectiveness of the COC pill. If you are prescribed one of these antibiotics, use additional contraception, such as a condoms, while you are taking the antibiotic and for seven days after finishing the course. If the seven days runs beyond the end of a pill pack, skip the pill free break, and start a new pack straight away. In the case of the every day (ED) pill; if the seven days runs into the inactive pills, skip the inactive pills and start a new pack straight away. If you are prescribed a long course of one of these antibiotics, after you have taken it for three weeks, or more, you do not need to use additional contraception. However, if you are then also prescribed a short course of a different antibiotic later, you will need to use additional contraception, as above. The COC pill may also interact with medicines that speed up how quickly the liver breaks down oestrogen and progestogen. These include: * aprepitant, * bosentan, * carbamazepine, * griseofulvin, * modafinil, * nelfinavir, * nevirapine, * oxcarbazepine, * phenytoin, * phenobarbital, * primidone, * rifabutin, * rifampicin, * ritonavir, * rufinamide, * St John's Wort (Hypericum), and * topiramate. As these medicines speed up the process of the liver breaking down the oestrogen and progestogen in the COC pill, they reduce the effectiveness of the COC pill. If you are prescribed a short course of one of these medicines, use additional contraception while you are taking the medicine, and for four weeks after you stop taking it. If you are prescribed a long course of one of the above medicines, remind your prescriber that you are taking a COC pill. You will need to think about switching to another method of contraception while you are taking it, and for 4-8 weeks after you stop taking it. Talk to your GP, or prescriber, about other methods of contraception. An alternative (except when taking rifampicin, or rifabutin) is to take two COC pills a day. However, this is an unlicensed use of the COC pill and it should only be taken in this way on the advice of your GP. Lamotrigine The combined oral contraceptive (COC) pill can speed up how quickly the liver breaks down lamotrigine. This reduces the amount of lamotrigine in the blood, making it less effective at controlling fits. Tell your GP if you decide to start (or stop) taking the COC pill because your dose of lamotrigine may need to be adjusted. Special considerations Blood clots The oestrogen in the combined oral contraceptive (COC) pill may cause your blood to clot more readily. If a blood clot develops, it could cause a deep vein thrombosis (DVT) (clot in your leg), pulmonary embolus (clot in the lung), or a stroke, or heart attack. However, the risk is very small - less than three out of 10,000 women taking the COC pill for a year will get a deep vein thrombosis. However, before prescribing the COC pill, your GP will check whether you have any risk factors. The COC pill may be taken with caution if you have one risk factor, but should not be taken if you have two, or more, risk factors. The risk factors include those described below. * Being over 35 years of age. * Smoking, or having stopped smoking in the last year. * Being very overweight - the COC pill may be taken with caution if your body mass index (BMI) is 35-40, but should not be taken if your BMI is over 40. * Migraine - you should not take the COC pill if you have severe migraine attacks (lasting over three days despite treatment) or you get regular migraine attacks, particularly if you get aura, or a warning sign before an attack, such as tingling in fingers, blurred vision, or feeling sick. * Having high blood pressure (hypertension). * Having had a blood clot, or a stroke, in the past. * Having a close relative who has had a blood clot when they were under 45 years of age. * Immobile for a long time - for example, if you are in a wheelchair, or have had your leg in plaster. Breast cancer Breast cancer has been found very slightly more often in women who take the COC pill than in women of the same age who do not. For women 35 years of age, or younger, who are not on the COC pill, the risk of developing breast cancer is four women out of 2,000. If the COC pill is taken, the risk increases to five women out of 2,000. If the COC pill is stopped, the risk of breast cancer developing reduces so that 10 years after stopping, the risk is the same as if you had never taken the COC pill. Endometrial and ovarian cancer The COC pill gives protection against developing cancers of the endometrium (lining of the womb) and the ovaries. Vomiting If you vomit within two hours of taking a COC pill, it may not have been fully absorbed into your bloodstream. Take another pill straight away and the next pill at your usual time. You should still be protected from pregnancy. However, if you continue to be you sick, you may not be protected from pregnancy. Diarrhoea Very severe diarrhoea (6-8 watery stools in 24 hours) may reduce the effectiveness of the COC pill. Keep taking the pill as normal, but treat each day that you have very severe diarrhoea as if you had forgotten to take a pill. See 'missed doses and extra doses', or speak to your GP, or family planning nurse. Alternatively, call NHS Direct on 0845 4647. Surgery Due to the risk of developing blood clots, you should stop taking the COC pill at least four weeks before a major operation, such as a joint replacement, or hysterectomy, or any surgery to your legs, such as treatment for varicose veins. You should not start taking the COC pill again until at least two weeks after you are completely mobile. There is no need to stop taking the COC pill before minor surgery, such as tooth extraction, or surgery involving a short duration of anaesthetic. Travel There is an increased risk of developing deep vein thrombosis (DVT) (a clot in the leg) during travel, if you are taking the COC pill and you are immobile for long periods (particularly long haul flights that are over five hours). You can help to prevent a DVT by drinking plenty of water, avoiding alcohol, which can lead to dehydration, and performing simple leg exercises Sexually transmitted infections (STIs) The COC pill will not protect you from sexually transmitted infections (STIs) including the human immunodeficiency virus (HIV), chlamydia, gonorrhoea, and syphilis. You should consider using condoms as well taking the COC pill. Breast feeding The COC pill may reduce your flow of milk. It is recommended that you use a different method of contraception, such as the progestogen only pill, or condoms, for the first six months of breastfeeding. Pregnancy The COC pill should not be taken during pregnancy. If you think that you could be pregnant, stop taking the COC pill and speak to your doctor Answered by Aracely Eldredge 2 months ago.

it's 2 harmful & even cause mal-sexual function Answered by Demetra Solien 2 months ago.

Yes it could, but probably negligible Answered by Gus Lacayo 2 months ago.

can cause high blood pressure or even stroke especially in older women Answered by Hollis Phaup 2 months ago.


Does anyone know anything about seroquel?
Asked by Kit Mcneese 2 months ago.

I've been precribed seroquel for anxiety/schizophrenia/insomnia, but it made me feel soooo tired the following morning that I quit taking it. I now take Geodon for sleep, abilify for schizophrenia and Lyrica for anxiety. There are several websites with information about seroquel: Answered by Alfonzo Hilke 2 months ago.

Hi I was on seroquel for about three months. I felt aweful on it. I just felt blah all the time Plus it caused me to have migraines almost daily. As soon as I was taken off it these symptons went away. If you are on it, I hope you don't get these symptons. Thank you! Hugs! Von! Answered by Candyce Acorda 2 months ago.

I took it for depression and it made me very sleepy and I had a huge appetite and gained 15 pounds in 3 weeks! Answered by Hildegarde Pote 2 months ago.

Yeah, I've taken it for about four years. It's good for skitzophrenia and trouble sleeping. Answered by Elisabeth Taque 2 months ago.

I've taken it and it gave me seizures my friend takes it and it makes her very tired Answered by Regina Haeder 2 months ago.

Look it up at webmd.com and you will get all the answers you would want. In the meantime ask your pharmacist and your prescribing doctor questions. Answered by Shelia Provis 2 months ago.


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