Application Information

This drug has been submitted to the FDA under the reference 020696/001.

Names and composition

"ANTIZOL" is the commercial name of a drug composed of FOMEPIZOLE.

Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
020696/001 ANTIZOL FOMEPIZOLE INJECTABLE/INJECTION 1.5GM per 1.5ML (1GM per ML)

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
020696/001 ANTIZOL FOMEPIZOLE INJECTABLE/INJECTION 1.5GM per 1.5ML (1GM per ML)
078368/001 FOMEPIZOLE FOMEPIZOLE INJECTABLE/INJECTION 1.5GM per 1.5ML (1GM per ML)
078537/001 FOMEPIZOLE FOMEPIZOLE INJECTABLE/INJECTION 1.5GM per 1.5ML (1GM per ML)
078639/001 FOMEPIZOLE FOMEPIZOLE INJECTABLE/INJECTION 1.5GM per 1.5ML (1GM per ML)
079033/001 FOMEPIZOLE FOMEPIZOLE INJECTABLE/INJECTION 1.5GM per 1.5ML (1GM per ML)

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Answered questions

If we give alcohol interaveinus , what happen ,what is mechanism of actoin?
Asked by Willette Burnison 1 year ago.

Ethyl alcohol is still given via the intravenous route. It is one of the two available options in treating methanol poisoning and ethylene glycol poisoning (the other option is a drug called Antizol (fomepizole)). Alcohol dehydrogenase (ADH) is the enzyme that metabolizes methanol, ethanol and ethylene glycol. This enzyme has a much greater affinity for ethanol and will choose it over the other two compounds. Since ADH is then busy metabolizing ethanol, the enzyme can not convert the other two compounds into toxic metabolites. It's complicated, but that's the quick and dirty explanation. Answered by Blondell Westerman 1 year ago.

It used to be used to stop premature labour. The mothers ofter gor tipsy and some vomited. Not used any more Answered by Syble Pushard 1 year ago.

depending how much is administered, it can depress the central nervous system and kill you. maybe it blocks receptor sites? i'm not sure. Answered by Elroy Maillet 1 year ago.


Biochemistry question, help please!?
Ethylene glycol (a component of antifreeze) is toxic and the cause of many cases of accidental and intentional poisoning. One effective treatment for ethylene glycol poisoning is the administration of an intoxicating dose of alcohol. Can you explain how this treatment works? Asked by Jesusa Bucey 1 year ago.

As with ethyl alcohol and methanol, ethylene glycol is metabolized by alcohol dehydrogenase to form glycoaldehyde. Through interaction with aldehyde dehydrogenase, ethylene glycol is then metabolized to glycolic acid (GA). A profound acidosis often ensues and is attributable to the glycolic acid in circulation. The patient may develop hyperventilation that results from acidemia. This glycolate is then transformed into glyoxylic acid. At this point, the molecule may be transformed into the highly toxic oxalate or the safer glutamate or a -ketoadipic acid metabolites. The administration of particular vitamins may promote the formation of these safer metabolites. With the formation of oxalate crystals in the urine, calcium oxalate crystals form and accumulate in blood and other tissues. The precipitation of calcium oxalate in the renal cortex results in decreased glomerular filtration and renal insufficiency. Calcium is consumed in circulation, and hypocalcemia may occur. The rate-dependent step of ethylene glycol metabolism is the alcohol dehydrogenase–catalyzed step. Ethyl alcohol binds much more easily to alcohol dehydrogenase than ethylene glycol or methanol does. Because ethanol is the preferential substrate for alcohol dehydrogenase, the presence of ethanol may essentially block metabolism of ethylene glycol. Antizol (fomepizole) is a new agent with a specific indication by the U.S. Food and Drug Administration for the treatment of ethylene glycol poisoning. Antizol is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the oxidation of ethanol to acetaldehyde. Alcohol dehydrogenase also catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites. Answered by Kirstie Ledyard 1 year ago.


How do I take care of my pitbull during winter?
I cant let her inside beacuse I have a another dog and shes a Chichu. Shes easy jelouse and Iam scared my pitbull will eat her. And as tryed before. I live in Texas so its not really that bad here in winter. Asked by Tatyana Dupouy 1 year ago.

This Site Might Help You. RE: How do I take care of my pitbull during winter? I have a female pitbull and she stays outside, its starting to get cold and I am worried about her! Should I buy her a sweter or put some blanquest outside? (At the momment it dirt and some grass but she lays in the dirt) Answered by Luanne Waygood 1 year ago.

first off you should have an insulated dog house for every season if the dog is going to be outside. make sure it has some sort of flap over the door to keep rain, snow, and cold wind off the dog. use straw for bedding. don't use blankets or towels, these can get damp from sweat or moisture build up and freeze in the winter. a dog is best kept around people, not outside where it has no one to see, play with, or be around. dogs are pack animals and like to be around their packs. by the way any animals and people in the family are considered the dogs pack. leaving the dog chained up outside all the time can cause tension and frustration in the dog. this could result in biting and/or aggression. Answered by Antonio Lockington 1 year ago.

I'm not sure what the weather is like where you live, but if you refuse to bring her in at least at night i would suggest a dog house with a Blanket in it. We live in So. California, and my dogs are inside every night in the winter, and in the summer some of them prefer to sleep inside and others prefer outside (we have 5 dogs). Letting her inside would be best Answered by Retha Justesen 1 year ago.

why not bring her inside? Pitbulls have short hair and its too cold in the winter for them! Dogs like to be inside with their families! Answered by Jamila Awtry 1 year ago.

You can't leave an outdoor dog with a sweater on.. If she gets caught up, she'll die.. You have to bring the dog into the house or get her a new home.. Dogs with such a short coat have no protection from the cold and cannot stay out all winter. A blanket in the dirt isn't going to save her life. Do you know how many people get charged every winter cause they leave their dogs out in the cold to freeze to death? TONS.. You want to be one of those people that get arrested for allowing their dog to freeze to death?? Bring her in the house.. If you don't like the dog, then find her a home where they will love her. Answered by Eleonore Camarero 1 year ago.

short hair is good for a few people, others, not. it depends just what u look like Answered by Guadalupe Apshire 1 year ago.

What is a blanquest and sweter? and why can't you bring her inside for the winter? Dogs with such a short coat have no protection from the cold and cannot stay out all winter. Answered by Bree Fyall 1 year ago.

I live in florida and could provide her a much better home.. I have one pit now and live on 5 acres.. my dog has it made and stays in the house.. contact me on my email account to work something out. breams83204@mypacks.net You shouldn't leave her outside like that during the winter Answered by Sofia Filion 1 year ago.

I've got mine both ways too... but our husband prefers it short... he never ever complains when I grow it very long, but is always all over him self w/the complements when I cut it off Answered by Wai Seeds 1 year ago.


Anti-Freeze poinsoning???
What are some of the side effects of accidentally ingesting antifreeze? Asked by Chu Mckinnie 1 year ago.

Alternative Names ..ethylene glycol poisoning. Defintion..Ethylene glycol is a common ingredient in antifreeze and windshield de-icer. If eaten or swallowed, it is poisonous.Ethylene glycol is very toxic. Every year, many people and animals are accidentally poisoned by ethylene glycol. The signs and symptoms of ethylene glycol poisoning are similar to alcohol intoxication. The first sign is slurred speech and a somewhat high feeling. Vomiting may occur. Later the central nervous system may become depressed, and coma can result. Congestive heart failure and fluids in and around the lungs may occur in later stages. The kidneys may stop working and death is possible. Eating or drinking ethylene glycol causes poisoning. Ethylene glycol is found in antifreeze and windshield de-icer and in other products. It tastes a very sweet and pets and children can ingest it by accident. Small amounts can be toxic. Laboratory exams done at the emergency room will test for too much acid in the blood. This condition is called metabolic acidosis. Certain crystals will also be found in the blood. Many antifreezes have a dye added to them. A black lamp will show this dye in the urine. There is also a test for ethylene glycol. Long-term effects depend on the amount of ethylene glycol swallowed and how much time goes by before treatment is started. Kidney failure, congestive heart failure, heart damage and death can occur. What are the treatments for the condition? Upon arrival at the emergency room, sodium bicarbonate may be given to correct the acidosis of the blood. The stomach may be pumped and cleaned if no more than 30 minutes have passed since swallowing. The medication fomepizole (i.e., Antizol, an antidote) may be given through an intravenous line into the arm. Some drugs can help change some of the toxic byproducts in the body. Dialysis may be done in cases of severe poisoning and if heart or kidney failure is likely. An individual can die from ethylene glycol poisoning. There can also be kidney failure and congestive heart failure that lingers after recovery. The healthcare professional can monitor ethylene glycol levels and kidney function in individuals who have been poisoned with ethylene glycol. Answered by Dennis Spiroff 1 year ago.

Symptoms of antifreeze poisoning include a drunken appearance including staggering, lack of coordination, and apparent disorientation and vomiting. The animal may appear listless and depressed. Because early signs of antifreeze poisoning often mimic signs of other illness, neither you or your veterinarian may suspect antifreeze poisoning until it is too late. Fortunately, in house lab tests performed by your veterinarian by assist in the diagnosis of antifreeze toxicity. Getting the dog to a veterinarian is critical within the first 9-12 hours following ingestion. After that length of time, the liver will have already begun metabolizing the ethylene glycol into substances that cause kidney failure and ultimately death. I have been asked the question by several people-What should be done immediately care for my pet. Should I induce vomiting or give activated charcoal to my pet? These are very short term fixes and not a cure. The faster your pet is treated by a veterinarian the better the chances of recovery. Again, this poison is extremely toxic. Answered by Lessie Tocher 1 year ago.

This Site Might Help You. RE: Anti-Freeze poinsoning??? What are some of the side effects of accidentally ingesting antifreeze? Answered by Hildred Peels 1 year ago.

Antifreeze Poisoning In Humans Answered by Claris Bowland 1 year ago.

Go to hospital-NOW. Drinking ethylene glycol will result in depression followed by heart and breathing difficulty, kidney failure, brain damage and even death. Used antifreeze may also contain metals, such as copper, zinc, and lead. Two ounces of ethylene glycol antifreeze can kill a dog, one teaspoon can be lethal to a cat, and two tablespoons can be hazardous to children. When ingested, ethylene glycol converts to oxalic acid which damages the kidneys and can cause kidney failure and death. Death by antifreeze poisoning often begins with a deceptive intoxication. As ethylene glycol—the sweet, syrupy toxin found in antifreeze—is absorbed into the bloodstream, it produces that tipsiness and slurred speech one might enjoy from a stiff cocktail. But the similarities end there. About 24 hours later, a searing headache develops, followed by nausea, dizziness, hyperventilation and delusions. The body's survival instincts kick in with vomiting and diarrhea—a futile attempt to expel the deadly poison. If an antidote is not administered quickly, death from acute kidney failure, heart attack or coma inevitably follows. Answered by Samantha Harrett 1 year ago.

It's extremely poisonous - even in small amounts. if you know someone who has ingested antifreeze, you should take them to a hospital emergency room immediately. Answered by Jeannette Reines 1 year ago.

antifreeze poinsoning Answered by Prudence Sovereign 1 year ago.

Two tablespoons can be hazardous to children, when ingested, ethylene glycol converts to oxalic acid which damages the kidneys and can cause kidney failure and death. Answered by Marjory Prill 1 year ago.

Usually says on a bottel that you might have injested it on, call poison controll center and ask them if you did swallow it because odds are your gona get sick. Answered by Martin Pedregon 1 year ago.


What is the lethal dosage of alcohol in mice?
second time around, no answer first time.I've found quite a bit of info on toxicity on various alcohols on humans and mice, but the LD50 doses I've seen listed have been oral or by inhalation. I'm looking for the injected (im or abdominal) LD50 of ethyl alcohol in an average 25 gram lab rat (or the general... Asked by Chelsea Weckerly 1 year ago.

second time around, no answer first time. I've found quite a bit of info on toxicity on various alcohols on humans and mice, but the LD50 doses I've seen listed have been oral or by inhalation. I'm looking for the injected (im or abdominal) LD50 of ethyl alcohol in an average 25 gram lab rat (or the general ml/L value) Lethal values of methanol and isopropanol would be appreciated as well. Answered by Rosana Shoe 1 year ago.

This Site Might Help You. RE: What is the lethal dosage of alcohol in mice? second time around, no answer first time. I've found quite a bit of info on toxicity on various alcohols on humans and mice, but the LD50 doses I've seen listed have been oral or by inhalation. I'm looking for the injected (im or abdominal) LD50 of ethyl alcohol in an average 25 gram lab rat... Answered by Illa Helowicz 1 year ago.

ANY alcohol can be lethal if you drink enough. You have to understand the meaning of the word MODERATION. Grain alcohol is 98% alcohol (196 proof), and most beer is 5%. 1 can of beer (5%/10 proof) is about equal to 1 ounce of 40%/80 proof liquor (a "normal shotglass is 2 ounces). Grain alcohol, like Everclear, is potent stuff. It is something I would NOT do as a shot...it needs to be mixed with something (preferably something fruity). I got extremely drunk on Everclear once and it was the start of a peptic ulcer in my stomach. That was the first AND last time I touched it. Also beware...grain alcohol is EXTREMELY flammable. Answered by Kindra Russnak 1 year ago.

Ethanol Ld50 Answered by Ayana Vinsel 1 year ago.

Ld50 Ethanol Answered by Meredith Rovelto 1 year ago.

Oral, mouse: LD50 = 3450 mg/kg; i dunno i don't think they do injected for that Answered by Isidra Curra 1 year ago.


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