ANTABUSE Ressources

Application Information

This drug has been submitted to the FDA under the reference 007883/002.

Names and composition

"ANTABUSE" is the commercial name of a drug composed of DISULFIRAM.

Answered questions

Has anyone tried taking Antabuse to help with alcoholism? Did it work? What were the side effects?
My husband has a serious drinking problem. I am desperate in finding something to help him stop drinking. He has tried many times but always goes right back. HELP me with any suggestions that you may have. Thanks Lisa Asked by Kaycee Garey 4 months ago.

Antabuse should never be administered to a patient when he is in a state of alcohol intoxication, or without his full knowledge. The physician should instruct relatives accordingly. Disulfiram is an aid in the management of selected chronic alcohol patients who want to remain in a state of enforced sobriety so that supportive and psychotherapeutic treatment may be applied to best advantage. Antabuse is not a cure for alcoholism. When used alone, without proper motivation and supportive therapy, it is unlikely that it will have any substantive effect on the drinking pattern of the chronic alcoholic. Disulfiram should never be administered until the patient has abstained from alcohol for at least 12 hours. Initial Dosage Schedule: In the first phase of treatment. a maximum of 500 mg daily is given in a single dose for one to two weeks. Although usually taken in the morning, Disulfiram may be taken on retiring by patients who experience a sedative effect. Alternatively, to minimize, or eliminate, the sedative effect, dosage may be adjusted downward. Maintenance Regimen: The average maintenance dose is 250 mg daily (range, 125 to 500 mg). it should not exceed 500 mg daily. Note: Occasionally patients. while seemingly on adequate maintenance doses of disutfiram, report that they are able to drink alcoholic beverages with impunity and without any symptomatology. All appearances to the contrary. such patients must be presumed to be disposing of their tablets in some manner without actually taking them. Until such patients have been observed reliably taking their daily disutfiram tablets (preferably crushed and well mixed with liquid), it cannot be concluded thal disulfiram is ineffective. Duration of Therapy The daily, uninterrupted administration of disulfiram must be continued until the patient is fully recovered socially and a basis for permanent self-control is established. Depending on the individual patient, maintenance therapy may be required for months or even years trial with Alcohol: During early experience with disulfiram, it was thought advisable for each patient to have at least one supervised alcohol-drug reaction. More recently, the test reaction has been largely abandoned. Furthermore, such a test reaction should never be administered to a patient over 50 years of age. A clear, detailed and convincing description of the reaction is felt to be sufficient in most cases. However, where a test reaction is deemed necessary, the suggested procedure is as follows: After the first one to two weeks therapy with 500 mg daily, a drink of 15 mL (1/2 oz) of 100 proof whiskey, or equivalent, is taken slowly. This test dose of alcoholic beverage may be repeated once only, so that the total dose does not exceed 30 ml (1 oz) of whiskey. Once a reaction develops, no more alcohol should be consumed. Such tests should be carried out only when the patient is hospitalized, or comparable supervision and facilities, including oxygen, are available. Management o f Disulfiram-Alcohol Reaction In severe reactions, whether caused by an excessive test dose or by the patient's unsupervised ingestion of alcohol, supportive measures to restore blood pressure and treat shock should be instituted. other recommendations include: oxygen, carbogen (95% oxygen and 5% carbon dioxide), vitamin C intravenously in massive doses (1 g) and ephedrine sulfate. Antihistamines have also been used intravenously. Potassium levels should be monitored, particularly in patients on digitalis, since hypokatemia has been reported. Answered by Cristy Goldstone 4 months ago.

Antabuse, as any drug containing disulfiram, may cause side effects - that s basically how disulfiram works. This drug is in use mostly in CEE, whereas in western countries it s not so popular as the way it works is a bit controversial. Disulfiram proved it s effectiveness in number of clinical trials, but in general results are better when it s used as an implant, not in pills. Reason for that is the fact addicted people tend to omit some doses to avoid side effects after drinking. Having a permanent implant makes it impossible. Answered by Kellee Vantuyle 4 months ago.

I have to agree with bmac about AA, as it is a huge part of recovery for most people if they want to get better-if your husband has tried, has he also tried by actually going to Alcohol counseling? For many people, AA alone is not enough and and Alcohol/Drug Treatment favility can provide counseling for both the alcoholic as well as the family (which is crucial in order to avoid re-enacting the familiar roles and patterns that lead to relapse). As far as meds go, Antabuse isn't particularly successful, but your husband may want to talk with a psychiatrist at an Alcohol treatment program about Naltrexone ( brand name Revia) as it has been helpful to some in reducing the cravings which is often the most difficult part of withdrawal, especially in early recovery. Good luck to you and your family! Answered by Jillian Cumbee 4 months ago.

Hi Lisa, hope my answer is not coming too late. There is a cure for your husband and anyone who has powerful cravings that cause them to override all logic and drink. It's call Naltrexone administered using The Sinclair Method. More informantion can be found in Claudia Christian's book "Babylon Condifential" and her documentary released in December 2014 called "One Little Pill". "The Cure for Alsoholism" by Dr. Roy Eskapa and Claudia's book can be found on Amazon. Saved my life. Had I known of TSM when I was younger, I would have done it. Best to you and your family, Will Answered by Mara Hoxie 4 months ago.

I am starting to go to al anon that helps. their is no reason to become addicted to something else so that it takes care of you addiction. Please email me if you need someone to talk to. Im on the same boat. We'll actually i got tired and left the boat. but im struggling Answered by Rigoberto Behymer 4 months ago.


Do you know anybody that has used antabuse?
its a pill for alcoholics to help them stop drinking , i want to know if it works , where i can buy it on line Asked by Maris Lily 4 months ago.

Antabuse absolutely works 100% for what it's designed for - it blocks an enzyme your body normally relies on to break down and excrete alcohol. Without this enzyme, acetaldehyde builds up very quickly if you drink resulting in nausea, vomiting, headaches, body aches - ie, an instant hangover. It basically takes the fun out of drinking. Antabuse as a tool to help stay sober is only part of a larger program. The first hurdle is to ensure that the person takes it every day, and is motivated to stop drinking - especially dedicated drinkers have been known to "drink through" the effects of antabuse. It's not legally available online, but if someone needs to get help, they can go to their doctor or their local health department. Answered by Apryl Shewchuk 4 months ago.

It works,causing you to suffer nausea and vomiting if drinking within 16-24 hours after taking the pill. You probably require a prescription, which should be easily obtainable at any free clinic. Answered by Marybelle Kelling 4 months ago.


Antabuse Question....?
Does anyone you know, or do you have an experience with this drug because I want to know what to expect when I take it.... ? What does it do to you, and does it really help?? Asked by Melodee Schamel 4 months ago.

Antabuse is used to treat chronic alcoholism. It causes unpleasant effects when even small amounts of alcohol are consumed. These effects include flushing of the face, headache, nausea, vomiting, chest pain, weakness, blurred vision, mental confusion, sweating, choking, breathing difficulty, and anxiety. These effects begin about 10 minutes after alcohol enters the body and last for 1 hour or more. Disulfiram is not a cure for alcoholism, but discourages drinking. This information was taken from medlineplus.gov. The link is listed below....more info there.... Answered by Galen Bomilla 4 months ago.

It makes you sick to your stomach if you drink alcohol. You should also join AA. Good luck. Answered by Cristy Fiebelkorn 4 months ago.


Do you know what is Antabuse ?
Asked by Karima Dallen 4 months ago.

Antabuse or disulfarim is a drug used to diminish the desire to drink alcohol. It has been widely used in rehab, detox and many outpatient and inpatient centers. Not only can you not drink alcohol while on this medication, one has to be aware of any external colognes, perfumes, shaving creams, any toiletries that may contain alcohol as they can cause an adverse reaction by being absorbed into the tissues through the dermis. Answered by Carlene Dolen 4 months ago.

Antabuse, which is also known as disulfiram, is the best pill to fight sobriety. This the first pill that gain approval for adolescent alcohol treatment. Answered by Shizue Stibb 4 months ago.

It make you sick if you drink alcohol Answered by Britta Nordhoff 4 months ago.

i hope the foll site helps you. Answered by Penney Casewell 4 months ago.


Tell me about Antabuse. Have you tried it. I'm desperate. Been to meetings and therapy.?
Asked by Genevive Lafkas 4 months ago.

Antabuse will make you very sick if you drink alcohol while taking it. Many people just can't stop irregardless of the antabuse. I suggest you go to 90 meetings in 90 days. It is okay to go even if you have been drinking. Just realize that quiting cannot be done by a pill. Look at tradition 3 every day and go to a meeting. Answered by Georgia Stanojevic 4 months ago.


Antabuse out of system?
i was wondering how long it takes for antabuse to get out of your system. i took my last dose of 250 mg on friday (2 days ago), and i usually only take 125 mg, which was administered thursday. before that, no antabuse was taken for a week. will it be out of my system by this friday (5 more days)? i have a fast... Asked by Ai Hassanein 4 months ago.

i was wondering how long it takes for antabuse to get out of your system. i took my last dose of 250 mg on friday (2 days ago), and i usually only take 125 mg, which was administered thursday. before that, no antabuse was taken for a week. will it be out of my system by this friday (5 more days)? i have a fast metabolism, i dont know if that has anything to do with it. Answered by Amelia Shumate 4 months ago.

The half life of Antabuse is 60-120 hours. "Half life" is the amount of time it takes for half of the amount of the drug in your system to be metabolized and eliminated. If you have a fast metabolism, let's go towards the bottom of that range, 72 hours (three days). If you took the last dose Friday, half of the drug would be eliminated by today (Monday). By Thursday, half of what is left will have been eliminated -- basically three quarters. By that time, the drug would no longer be working, though 25% would still be in your system. It takes another three days for half of that to be metabolized, and so on. The drug would likely be out of your system in about two weeks (based on metabolism rate toward the lower or fasted end of the scale). For slower metabolisms, this length of time would be doubled. Answered by Heath Penny 4 months ago.

Antabuse Half Life Answered by Carl Schoppert 4 months ago.

This Site Might Help You. RE: antabuse out of system? i was wondering how long it takes for antabuse to get out of your system. i took my last dose of 250 mg on friday (2 days ago), and i usually only take 125 mg, which was administered thursday. before that, no antabuse was taken for a week. will it be out of my system by this friday (5 more days)? i... Answered by Tressa Madan 4 months ago.

dude, I took 250 mg antabuse for 3 days straights last pill was day 3 at 9:35pm and i drank at 8pm the following evening and nothing happened only the pleasure of drinking. Answered by Artie Aske 4 months ago.


Anyone ever been prescribed, or know someone who's been prescribed, Antabuse? If so, what were the results?
Asked by Marilynn Blake 4 months ago.

Someone very close to me is a recovering alcoholic and has been taking antabuse regularly for the past 4 years. Basicly, if a person drinks any alcohol while taking antabuse they will become very ill. The most obvious symptom is that the person will become very red and flushed. They will also experience nausea, vomiting and severe headaches. If the person drinks enough alcohol they may require hospitilization. It is important that they avoid alcohol all together because even a small amount can cause a reaction. Antabuse can be very hard on the liver, so the person taking it should have their liver functions tested regularly, especially if they have a history of alcohol abuse. As long as the person does not drink alcohol while on antabuse they should not really notice any side effects. Drowsiness can occur and in some people and some notice a garlicy taste in their mouths. Antabuse does take a couple of days to get out of the body, so even if the person skips today's dose and drinks, they will probably still experience the ill effects. If this person is serious about stopping drinking and taking antabuse, it is best to have someone else give them their pill daily. I know from years of experience that alcoholics can be very sneaky and manipulative. Sometimes they cannot be trusted to take their pills, eventhough they truly mean or want to. Antabuse alone cannot stop an alcoholic from drinking. They really do need the support of Alcoholics Anonymous. I have seen it work miracles for hundreds of people. Answered by Jack Putalavage 4 months ago.

The results are that you can get violently ill if you drink while taking it. I was in the Navy and had cohorts who were required to take it. They drank anyway. Since they were accoutomed to becoming violently ill anyway, nothing new So alone, it does nothing good for you. If you want to change sincerely, maybe you can do without it. But if you are being mandated to use it by the courts, yes, people do survive drinking on it but I have seen some guys really blow up and get wretchedly ill, which was their intent because they wanted out of the Navy badly. I would say, DO NOT DRINK on antibuse And if you want to stop drinking, plenty of people do it without antibuse through treatment and 12 step, so in my opinion, it is useless and potentially dangerous Answered by Francisco Lerch 4 months ago.

i knew someone and he puked his guts out until he stopped drinking Answered by Gena Cuch 4 months ago.


Has anyone been on antabuse?
What are the effects when alcohol is consumed? Do you consider it an effective treatment? Asked by Crystal Muldowney 4 months ago.

Antabuse is effective it will make you so sick if you drink alcohol.If you try it do not plan on drinking any alcohol at all. Answered by Delmer Mollenkopf 4 months ago.

Disulfiram is a drug used to support the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Trade names for disulfiram in different countries are Antabuse and Antabus manufactured by Odyssey Pharmaceuticals. Disulfiram is also being studied as a treatment for cocaine dependence, as it prevents the breakdown of dopamine (a neurotransmitter whose release is stimulated by cocaine); the excess dopamine results in increased anxiety, higher blood pressure, restlessness and other unpleasant symptoms. Under normal metabolism, alcohol is broken down in the liver by the enzyme alcohol dehydrogenase to acetaldehyde, which is then converted by the enzyme acetaldehyde dehydrogenase to the harmless acetic acid. Disulfiram blocks this reaction at the intermediate stage by blocking the enzyme acetaldehyde dehydrogenase. After alcohol intake under the influence of disulfiram, the concentration of acetaldehyde in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone. As acetaldehyde is one of the major causes of the symptoms of a "hangover" this produces immediate and severe negative reaction to alcohol intake. Some 5-10 minutes after alcohol intake, the patient may experience the effects of a severe hangover for a period of 30 minutes up to several hours. Symptoms include flushing of the skin, accelerated heart rate, shortness of breath, nausea, and vomiting. Disulfiram should not be taken if alcohol has been consumed in the last 12 hours. There is no tolerance to disulfiram: the longer it is taken, the stronger its effects. As disulfiram is absorbed slowly through the digestive tract and eliminated slowly by the body the effects may last for up to 2 weeks after the initial intake; consequently, medical ethics dictate that patients must be fully informed about the disulfiram-alcohol reaction. The drug's action was discovered by accident in the 1948 by the researchers Erik Jacobsen and Jens Hald at the Danish drug company Medicinalco. The substance was intended to provide a remedy for parasitic infestations; however, workers testing the substance on themselves reported severe symptoms after alcohol consumption. From a practical standpoint, disulfiram is not a "cure" for alcoholism, since it is easier for an alcoholic to stop taking disulfiram than alcohol; if the treatment is not supervised, an alcoholic may abandon the treatment — and even when disulfiram therapy is strictly enforced, the negative effects are rarely enough to break the drinking patterns of a chronic alcoholic. In some extreme cases, patients with subcutaneous disulfiram tablet implants have been known to cut or dig out the tablet to avoid its effects. For these reasons, disulfiram is usually only indicated for select patients who wish to remain in an enforced state of sobriety during other forms of treatment, such as support groups and psychotherapy. Answered by Apolonia Magnus 4 months ago.

My cousin was on Anatabuse and took a drink of alcohol and it made her deathly sick. Her respirations were affected almost to the point where she couldn't breathe at all on her own. It can kill you if you don't watch. Watch for the alcohol in mouthwash and other health and beauty aids. Also watch for alcohol content in OTC medications too. It is effective if taken properly and not drinking, drugs or anything with alcohol! Answered by Allegra Monkhouse 4 months ago.


Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
007883/002 ANTABUSE DISULFIRAM TABLET/ORAL 500MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
007883/003 ANTABUSE DISULFIRAM TABLET/ORAL 250MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
088482/001 ANTABUSE DISULFIRAM TABLET/ORAL 250MG
088483/001 ANTABUSE DISULFIRAM TABLET/ORAL 500MG

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
007883/002 ANTABUSE DISULFIRAM TABLET/ORAL 500MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
007883/003 ANTABUSE DISULFIRAM TABLET/ORAL 250MG **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**
086889/001 DISULFIRAM DISULFIRAM TABLET/ORAL 250MG
086890/001 DISULFIRAM DISULFIRAM TABLET/ORAL 500MG
087973/001 DISULFIRAM DISULFIRAM TABLET/ORAL 250MG
087974/001 DISULFIRAM DISULFIRAM TABLET/ORAL 500MG
088482/001 ANTABUSE DISULFIRAM TABLET/ORAL 250MG
088483/001 ANTABUSE DISULFIRAM TABLET/ORAL 500MG
088792/001 DISULFIRAM DISULFIRAM TABLET/ORAL 250MG
088793/001 DISULFIRAM DISULFIRAM TABLET/ORAL 500MG
091563/001 DISULFIRAM DISULFIRAM TABLET/ORAL 250MG
091563/002 DISULFIRAM DISULFIRAM TABLET/ORAL 500MG
091619/001 DISULFIRAM DISULFIRAM TABLET/ORAL 250MG
091619/002 DISULFIRAM DISULFIRAM TABLET/ORAL 500MG
091681/001 DISULFIRAM DISULFIRAM TABLET/ORAL 250MG
202652/001 DISULFIRAM DISULFIRAM TABLET/ORAL 250MG
202652/002 DISULFIRAM DISULFIRAM TABLET/ORAL 500MG
203916/001 DISULFIRAM DISULFIRAM TABLET/ORAL 250MG
203916/002 DISULFIRAM DISULFIRAM TABLET/ORAL 500MG

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