AMPHOTERICIN B Ressources

Application Information

This drug has been submitted to the FDA under the reference 062728/001.

Names and composition

"AMPHOTERICIN B" is the commercial name of a drug composed of AMPHOTERICIN B.

Answered questions

What is the emperic therapy for suspected systemic fungemia in neutropenic patients?
Terbinafine Nystatin Amphotericin B Ketoconazole Griseofulvin? Asked by Alexis Verrecchia 3 months ago.

Amphotericin B. Once a severely immunocompromised patient is diagnosed with fungi in the bloodstream, it is almost certainly going to be fatal. The only hope is a wide spectrum, systemic drug such as a polyene (amphotericin and nystatin are the only two polyenes commercially avaialble that I am aware of). Some clinicians also suggest the addition of flucytosine. Flucytosine is a DNA synthesis inhibitor, and has shown the ability to augment ampho's efficacy. Again, though, presenting with systemic fugemia is almost always a death sentence. Answered by Conception Alejandre 3 months ago.


Another question about amphotericin b...?
For what it's worth, I've seen an infectious disease specialist. She cultured my yeast and it *should be* susceptible to difllucan, which I have been on for two months (200mgs a day) and my infection has only continued to get worse. She won't do anything else, because the diflucan *should* work. Asked by Shante Sheperd 3 months ago.

Ok...I see my internist tomorrow and I am really going to push for him to admit me and order this med. I've done my homework...the side effects sound absolutely hellish but if the med may work, I'm willing to give it a try. I know my infection isn't really considered severe but I've had it since mid-September, and none of the many drugs thrown at it have worked, including another IV med, Caspofungin, I think it was called. Anyways, this is my question. I know amphotericin can cause liver and kidney problems. Does their function return to normal after the drug is stopped, or is the damage permanent? Need to know before I make the decision to try this. Would like to know before I see my doc because I won't even consider it if the effects are permanent. Answered by Dortha Outhouse 3 months ago.

To put it simply, yes, the liver and kidney damage may be permanent. It isn't 100% permanent--some people who use Amphotericin B will be able to get over the damage in time, some people will be stuck with permanent organ damage. The wikipedia site has a nice summary of the side effects of amphotericin B. It should be linked below. On a side note, Amphotericin B is usually not perscribed without consultation with an infectious disease specialist. If you have a persistent infection that your internist is having trouble treating, a visit with an infectious disease specialist would be a good next step instead of forcing a hospitalization and a dangerous medication that you could potentially not need. Answered by Hsiu Rittenberry 3 months ago.

Maybe any damage is reversible and maybe it isn't, but I wouldn't push. There are, for most fungal infections, other alternatives to "amphoterrible," and you may have better options yet. Answered by Loree Strollo 3 months ago.


Amphotericin b...has anyone used?
They wouldn't send me home with the PICC....I just don't hav any veins....I'm diabetic, and my veins are shot. So when there are going to be multiple blood draws, I insist on a PICC so I don't have to be poked a million times. Asked by Karina Mckibbon 3 months ago.

My internist was talking about using this. My fungal infection isn't really considered "severe" but it's been very stubborn, resisting everything else we've thrown at it, so if my doc is willing to give it to me, I think I'm willing to try it. I know I would have to be inpatient and have a picc line in, but I've been fighting yeast (it's been cultured, we know it IS yeast) since late September. Answered by Tanesha Wrigley 3 months ago.

No, but I have prescribed amphotercin b before. It is an IV antifungal. The good news is it that ampho B has industrial strength killing power. The bad news... is that ampho B has industrial strength killing power. Ampho B fell out if favor because of the high rates of adverse reactions including of kidney, blood and liver complications. Your internist will surely want to monitor your kidney function (BUN/Cr) liver function (LFTs) and blood counts (CBC) It is usually only given in the hospital setting for this reason. I'm suprised they are sending you home with a PICC line to take it. I don't know your history, your exam or what meds you've tried and failed so I will not try to diagnose you or recommend treatment. I will assume your MD has tried the many newer (relatively safer) antifungals like Cancidas (caspofungin) and all the classics like Diflucan (fluconazole) and Sporanox (itraconazole). I will also assume you have been worked up for an immune deficiency cause. (Most healthy immune systems do not get severe fungal infections). Consider asking your doctor to walk through everything that has been done so far and explain why AmphoB is the best option. Also, consider asking for an Infectious Disease consultation. When all other antifungals fail, that is when we fall back to old amphoB. It works, but make sure they are watching you closely. Answered by Sergio Naone 3 months ago.


Amophotericin b for chronic and systemic yeast infections?
anyone ever have amphotericin b intravenously for their chronic or systemic yeast infections? what's your story? did it work? Asked by Nora Patraw 3 months ago.

Amphotericin B can cause serious side effects. This medication should only be used for the treatment of potentially life-threatening fungal infections and not to treat less serious fungal infections of the mouth, throat, or vagina . It is an old drug now replaced by safer and more modern anti-fungal drugs. Answered by Jacelyn Dergurahian 3 months ago.

Systemic yeast infection is a bit of a buzz word although there are people prone to digestive difficulties and skin lesions due to over populated candida. Candida (part of the yeast family) becomes over populated in the gut due to stress, diet and structural changes in the gut. This is from hormonal changes (due to the sympathetic and parasympathetic imbalance) and can also be affected by posture and how the muscles of the abdomen hold the guts in place. You will always have candida in the gut and these compete with the good symbiotic bacteria which aid digestion by swamping the walls of the intestines and feeding on foods it likes and releasing toxins as waste products generally making you feel a bit rubbish. You can help change the balance by using probiotics either in capsule form or ingesting products like live youghurt. You can also eat food rich in fructa oliga sacharides which help to feed the good bacteria. Vegetables such as chicory are especially rich in this group of complex carbs. Eating foods with a low Glaecamic index will be helpful as these are not so readily prefered by candida and also release their energy much more slowly not raising your blood sugar(conincidently foods rich in fructa oliga sacharides tend to be low GI). High blood sugar also leads to increases in extenal fungal infections such as athletes foot and thrush for the simple reason that these opportunistic infections have a nicer environment to thrive in if the hosts has high blood sugar. This is another reason to keep to a low GI diet. Stress also raises your blood sugar levels and affects the sympathetic and parasympathetic balance in your guts. You can change your posture with exercise like pilates which will help tone your abdominals as well. I am not a homeopath but have met many inteligent people who find the remedies effective so am not convinced the remedy is entirely placebo. I'm of the opinion that just because we cannot understand why something works doesn't mean that it cannot be the case and something else must be doing it..... The anti-homeopath lobby isn't entirely forthcoming about all the test data because like anyone wanting to prove a point they will only show the evidence which fortifies their opinion and don't show you anything which contradicts it. Homeopaths will do the same. What should an open minded person do? Look at the evidence from both sides and make an informed choice. Homeopathy is a very safe therapy and the worst that will happen is the treatment wont work, but you will have no side effects. There will certainly be no harm in using them to enhance the other measures you can take or you may prefer to just try them on their own. Hope this helps. Answered by Tomeka Hokutan 3 months ago.

Amphotericin B is an extremely strong drug with some horrible side effects. They don't call it "Amphoterrible B" for no reason. That particular drug is way overkill for something that you are describing and would be the last thing they would use. Answered by Shonta Iniquez 3 months ago.


Why does amphotericin B has severe side effects in humans?
Asked by Christeen Hieber 3 months ago.

Amphotericin B is associated with renal toxicity. It is important if on Ampho to be recieving adequate hydration to flush the kidneys. It also is associated with a relatively high rate of anaphylactic (severe allergic) reactions. However, the Amphotericin B used now is much less likely to cause problems than its older generation counterpart (although it does still make me nervous when I have to give it to patients!) Answered by Patience Bensing 3 months ago.

Side Effects Of Amphotericin B Answered by Somer Occhiogrosso 3 months ago.

Keeping in mind that any medication is a foreign substance in your body and can cause side effects, Amphotericin B interacts with about three dozen common medications. The most severe (relative) side effect is renal failure. Amphotericin B should only be used for the treatment of potentially life-threatening fungal infections and not to treat less serious fungal infections of the mouth, throat, or vagina in patients with a normal immune system, which tells you something right there. Answered by Aubrey Lagrow 3 months ago.


What is the biological source and spectrum of amphotericin?
Asked by Marline Pressey 3 months ago.

Amphotericin B (Fungilin, Fungizone, Abelcet, AmBisome, Fungisome, Amphocil, Amphotec) is a polyene antifungal drug, often used intravenously for systemic fungal infections. It was originally extracted from Streptomyces nodosus, a filamentous bacterium, in 1955 at the Squibb Institute for Medical Research from cultures of an undescribed streptomycete isolated from the soil collected in the Orinoco River region of Venezuela. Its name originates from the chemical's amphoteric properties. Two amphotericins, Amphotericin A and Amphotericin B are known, but only B is used clinically because it is significantly more active in vivo. Oral preparations of amphotericin B are used to treat oral thrush; these are virtually nontoxic. The main i.v. use is in systemic fungal infections (e.g. in immunocompromised patients), and in visceral leishmaniasis. Aspergillosis, Naegleria fowleri primary amoebic meningoencephalitis, cryptococcus infections (e.g. meningitis) and candidiasis are treated with amphotericin B. It is also used empirically in febrile immunocompromised patients who do not respond to broad-spectrum antibiotics. Answered by Daniella Dimaio 3 months ago.


The antibiotic amphotericin B causes leaks in cells by combining with sterols in the plasma membrane.?
The antibiotic amphotericin B causes leaks in cells by combining with sterols in the plasma membrane. Would you expect for bacteria to be sensitive to this antibiotic, why or why not? Asked by Marco Neitzel 3 months ago.

Amphotericin B is primarily an antifungal agent, as the ergosterol that it binds to is principally found in fungal cell membranes. You would expect it to be useful against any bacteria with ergosterols in their membranes, but I did not find any information about ergosterol ever being present in bacteria membranes. Answered by Sacha Budrovich 3 months ago.

Totally agree with aestatis. Will add that bacteria do lack the necessary binding sites for polyene anitimicotics like amphotericin B. Mammalian cell membranes do contain sterols and a lot of the side effects of this drug relate to this problem eg: haemolysis in some patients. Answered by Brain Barash 3 months ago.

Mr.Ireland told me to focus on what the steols do. The research I found states that the amphotericin B anitibiotic channels in the bacterial membrane to determine the mechanism of its known antibiotic resistance. I think it just kills the entire cell? I cannot find this one have you found anything? Answered by Ingeborg Troop 3 months ago.


Where can I buy Amphotericin B Oral for my bird?
For anyone who has been following, my Timneh Grey has not improved. His appetite is better but his seeds are still passing undigested and he's not gaining weight. He is still on .10 Baytril compound twice daily, has heat, and I hand feed a puree once a day (which he loves.) These things are simply keeping... Asked by Clark Eerkes 3 months ago.

For anyone who has been following, my Timneh Grey has not improved. His appetite is better but his seeds are still passing undigested and he's not gaining weight. He is still on .10 Baytril compound twice daily, has heat, and I hand feed a puree once a day (which he loves.) These things are simply keeping him going-they're obviously not curing the problem. I am awaiting a call from my avian vet to discuss Megabacteria, hopefully he's heard of this. I am convinced from my bird's actions this is what he has. Where/how can I buy Amphotericin B in oral form for him in case my vey isnt helpful? I haven't been able to locate a website. Is it only by prescription? Answered by Kyoko Heiden 3 months ago.


Why amphotericin B soluble at 12 pH in the presence of sodium desoxy cholate. what is the chemistry behind it.
amphotericin B formulation Asked by Alexandra Kurpiel 3 months ago.

amphotericin B is acidic in nature. Answered by Miranda Gerrish 3 months ago.


Amphotericin B for stubborn yeast infection?
Okay please bare with me. I am 19 years old, very clean, no stds, one partner my whole life.I got my first yeast infection in February. No big deal, doctor prescribed me diflucan and a supository. Well.. It came back. More diflucan, monistat. Thought that would take care of it, then it came back again and ibtook... Asked by Lela Ellies 3 months ago.

Okay please bare with me. I am 19 years old, very clean, no stds, one partner my whole life. I got my first yeast infection in February. No big deal, doctor prescribed me diflucan and a supository. Well.. It came back. More diflucan, monistat. Thought that would take care of it, then it came back again and ibtook a 2 month course of diflucan with monistat. Thought that would take care of it, and then i got another one. I was fed up. I wrnt to another doctor and she actually seemed like she knew what i was talking about. She said that i probably have a different strain of yeast and that it was most likely candida glabrata and to treat it with amphotericin b for a month. Im really hoping this will work because i have had no sex life and it has even made me suicidal. Has anybody had success with this? & can you still use it while you are on your period? Please only answer if you know of this medication or have used it. I am very nervous that it will not work. Thanks. Answered by Frederica Pickerell 3 months ago.

Ok, First of all...a two month course of Diflucan? Normally the most I've ever seen it given (my wife has some severe ones at times) is a three day dose taken every other day. Your first doctor seems like they're not as up to speed on woman problems as they ought to be. Secondly your second doctor is likely correct. You may indeed not have the garden variety yeast infection and Amphotericin B is an anti-fungal agent that may treat the condition. Thirdly don't worry about what anyone is going to think about you getting these yeast infections. It happens to EVERY woman at some point in her life. Especially if she's ever been on antibiotics. My daughter had herself a meltdown thinking that we were going to think that she "was a slut" (her words) for getting one. It's normal. It happens, and there's not a whole lot you can do about it. Save going to a doctor (who has a frigging clue) to get something to treat it. Answered by Elina Goodkin 3 months ago.

I would just wait until the symptoms of the yeast infection is gone......that infection can be passed on. Believe it or not, my grandson (he's 16 months) got a yeast infection from strong antibiotics he was on. His little balls swelled up like golf balls and he had a horrible rash. Males can get it too......just wait until the symptoms are gone and then you should be okay. BEEN THERE ON MANY OCCASIONS - UNFORTUNATELY. Answered by Rosio Chittom 3 months ago.


Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
062728/001 AMPHOTERICIN B AMPHOTERICIN B INJECTABLE/INJECTION 50MG per VIAL
063206/001 AMPHOTERICIN B AMPHOTERICIN B INJECTABLE/INJECTION 50MG per VIAL
064062/001 AMPHOTERICIN B AMPHOTERICIN B INJECTABLE/INJECTION 50MG per VIAL
064141/001 AMPHOTERICIN B AMPHOTERICIN B INJECTABLE/INJECTION 50MG per VIAL

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
050313/001 FUNGIZONE AMPHOTERICIN B OINTMENT/TOPICAL 3%
050314/001 FUNGIZONE AMPHOTERICIN B CREAM/TOPICAL 3%
050341/003 FUNGIZONE AMPHOTERICIN B SUSPENSION/ORAL 100MG per ML
050724/001 ABELCET AMPHOTERICIN B INJECTABLE, LIPID COMPLEX/INJECTION 5MG per ML
050729/001 AMPHOTEC AMPHOTERICIN B INJECTABLE, LIPID COMPLEX/INJECTION 50MG per VIAL
050729/002 AMPHOTEC AMPHOTERICIN B INJECTABLE, LIPID COMPLEX/INJECTION 100MG per VIAL
050740/001 AMBISOME AMPHOTERICIN B INJECTABLE, LIPOSOMAL/INJECTION 50MG per VIAL
060517/001 FUNGIZONE AMPHOTERICIN B INJECTABLE/INJECTION 50MG per VIAL
060570/001 FUNGIZONE AMPHOTERICIN B LOTION/TOPICAL 3%
062728/001 AMPHOTERICIN B AMPHOTERICIN B INJECTABLE/INJECTION 50MG per VIAL
063206/001 AMPHOTERICIN B AMPHOTERICIN B INJECTABLE/INJECTION 50MG per VIAL
064062/001 AMPHOTERICIN B AMPHOTERICIN B INJECTABLE/INJECTION 50MG per VIAL
064141/001 AMPHOTERICIN B AMPHOTERICIN B INJECTABLE/INJECTION 50MG per VIAL

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